Dr Muy-Teck Teh
Senior Lecturer
Centre for Oral Immunobiology & Regenerative Medicine, Institute
Queen Mary University of London
Queen Mary University of London
Research
cancer spheroids, 3D in vitro culture model, chemoresistance, high-throughput 3D drug screening, transcriptome pattern recognition, mRNA biomarkers
Interests
We are developing a high-throughput 3D cancer spheroid drug screening method to identify drugs that could counteract chemoresistance and identify transcriptome biomarker for predicting drug-gene interaction.Publications
Publications of specific relevance to Predictive in vitro Models
2024
Usman S, Bushaala A, Teh MT and Waseem A (2024). Site-Directed Mutagenesis to Mutate Multiple Residues in a Single Reaction. Springer Nature 10.1007/7651_2023_511
2023
Wan H, Teh M-T, Mastroianni G and Ahmad US (2023). Comparative Transcriptome Analysis Identifies Desmoglein-3 as a Potential Oncogene in Oral Cancer Cells. Mdpi Cells vol. 12, (23) 10.3390/cells12232710
Teh M-T (2023). Identification of multidrug chemoresistant genes in head and neck squamous cell carcinoma cells. Biomed Central Molecular Cancer 10.1186/s12943-023-01846-3
Perussolo J, Teh M-T, Gkranias N, Tiberi S, Petrie A, Cutino-Moguel M-T and Donos N (2023). Efficacy of three antimicrobial mouthwashes in reducing SARS-CoV-2 viral load in the saliva of hospitalized patients: a randomized controlled pilot study. Springer Nature Scientific Reports vol. 13, (1) 10.1038/s41598-023-39308-x
2022
Waseem A (2022). Transcriptome Analysis Reveals Vimentin-Induced Disruption of Cell–Cell Associations Augments Breast Cancer Cell Migration. Mdpi Cells 10.3390/cells11244035
Usman S, Aldehlawi H, Nguyen TKN, Teh M-T and Waseem A (2022). Impact of N-Terminal Tags on De Novo Vimentin Intermediate Filament Assembly. Mdpi International Journal of Molecular Sciences vol. 23, (11) 6349-6349. 10.3390/ijms23116349
Teh M-T (2022). Molecular Signatures of Tumour and Its Microenvironment for Precise Quantitative Diagnosis of Oral Squamous Cell Carcinoma: An International Multi-Cohort Diagnostic Validation Study. Mdpi Ag Cancers 10.3390/cancers14061389
Mech AM, Merteroglu M, Sealy IM, Teh M-T, White RJ, Havelange W, Brennan CH and Busch-Nentwich EM (2022). Behavioral and Gene Regulatory Responses to Developmental Drug Exposures in Zebrafish. Frontiers Frontiers in Psychiatry vol. 12, 10.3389/fpsyt.2021.795175
2021
Sapkota D, Sharma S, Søland TM, Braz‐Silva PH and Teh M (2021). Expression profile of
SARS‐CoV‐2
cellular entry proteins in normal oral mucosa and oral squamous cell carcinoma. Wiley Clinical and Experimental Dental Research 10.1002/cre2.510
Usman S (2021). Vimentin Is at the Heart of Epithelial Mesenchymal Transition (EMT) Mediated Metastasis., Editors: Philip Gregory . Mdpi Cancers vol. 13, (19) 4985-4985. 10.3390/cancers13194985
Ponzoni L, Melzi G, Marabini L, Martini A, Petrillo G, Teh M-T, Torres-Perez JV, Morara S, Gotti C, Braida D, Brennan CH and Sala M (2021). Conservation of mechanisms regulating emotional-like responses on spontaneous nicotine withdrawal in zebrafish and mammals. Elsevier Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 111, 10.1016/j.pnpbp.2021.110334
Usman S, Jamal A, Teh M-T and Waseem A (2021). Major Molecular Signaling Pathways in Oral Cancer Associated With Therapeutic Resistance. Frontiers in Oral Health vol. 1, 603160-603160. 10.3389/froh.2020.603160
2020
Ponzoni L, Teh MT, Torres-Perez JV, Brennan CH, Braida D and Sala M (2020). Increased Response to 3,4-Methylenedioxymethamphetamine (MDMA) Reward and Altered Gene Expression in Zebrafish During Short- and Long-Term Nicotine Withdrawal. Springer (Part of Springer Nature) Molecular Neurobiology 10.1007/s12035-020-02225-5
Teh M-T (2020). RASSF1A inhibits PDGFB-driven malignant phenotypes of nasopharyngeal carcinoma cells in a YAP1-dependent manner. Nature Publishing Group Cell Death and Disease 10.1038/s41419-020-03054-z
Garcia Gonzalez J, Brock A, Parker M, Riley R, Joliffe D, SUDWARTS A, Teh M-T, Busch-Nentwich E, Stemple D, Martineau A, Kaprio J, Kuan V, Walton R and Brennan C (2020). Identification of Slit3 as a locus affecting nicotine preference in zebrafish and human smoking behaviour. Elife Sciences Publications Ltd Elife 10.7554/eLife.51295
Aldehlawi H, Usman S, Lalli A, Ahmad F, WILLIAMS G, Teh M-T and Waseem A (2020). Serum lipids, retinoic acid and phenol red differentially regulate expression of keratins K1, K10 and K2 in cultured keratinocytes. Nature Publishing Group Scientific Reports vol. 10, (4829) 10.1038/s41598-020-61640-9
Teh M-T (2020). A Novel Diagnostic Tool for Cancer Detection. Science Diffusion Ltd Scientia 10.33548/scientia572
2019
Uttagomol J, Ahmad US, Rehman A, Huang Y, Laly AC, Kang A, Soetaert J, Chance R, Teh M-T, Connelly JT and Wan H (2019). Evidence for the Desmosomal Cadherin Desmoglein-3 in Regulating YAP and Phospho-YAP in Keratinocyte Responses to Mechanical Forces. Mdpi International Journal of Molecular Sciences vol. 20, (24) 10.3390/ijms20246221
Teh M-T (2019). The transcription factor FOXM1 regulates the balance between proliferation and aberrant differentiation in head and neck squamous cell carcinoma. Wiley Journal of Pathology 10.1002/path.5342
Yeung J-YS, Hutchison I, Waseem A and Teh M-T (2019). qMIDS: A Digital Diagnostic Test for Oral Cancer. British Journal of Oral and Maxillofacial Surgery vol. 57, (10) e86-e87. 10.1016/j.bjoms.2019.10.252
Rehman A, Cai Y, Hünefeld C, Jedličková H, Huang Y, Teck Teh M, Sharif Ahmad U, Uttagomol J, Wang Y, Kang A, Warnes G, Harwood C, Bergamaschi D, Kenneth Parkinson E, Röcken M and Wan H (2019). The desmosomal cadherin desmoglein-3 acts as a keratinocyte anti-stress protein via suppression of p53. Springer Nature Cell Death & Disease vol. 10, (10) 10.1038/s41419-019-1988-0
Teh M-T (2019). Clinical correlation of opposing molecular signatures in head and neck squamous cell carcinoma. Biomed Central Bmc Cancer 10.1186/s12885-019-6059-5
ALDEHLAWI H, Niemiec NA, AVISETTI DR, LALLI A, Teh M-T and WASEEM A (2019). The monoclonal antibody EPR1614Y against the stem cell biomarker keratin K15 lacks specificity and reacts with other keratins. Nature Publishing Group Scientific Reports vol. 9, 10.1038/s41598-018-38163-5
2018
TEH M (2018). Transcriptome reprogramming by cancer exosomes: identification of novel molecular targets in matrix and immune modulation. Biomed Central Molecular Cancer 10.1186/s12943-018-0846-5
2017
Pantazi E, Gemenetzidis E, Teh M-T, Reddy SV, Warnes G, Evagora C, Trigiante G and Philpott MP (2017). GLI2 Is a Regulator of β-Catenin and Is Associated with Loss of E-Cadherin, Cell Invasiveness, and Long-Term Epidermal Regeneration. Elsevier Journal of Investigative Dermatology vol. 137, (8) 1719-1730. 10.1016/j.jid.2016.11.046
2016
Parajuli H, Teh MT, Abrahamsen S, Christoffersen I, Neppelberg E, Lybak S, Osman T, Johannessen AC, Gullberg D, Skarstein K and Costea DE (2016). Integrin α11 is overexpressed by tumour stroma of head and neck squamous cell carcinoma and correlates positively with alpha smooth muscle actin expression. J Oral Pathol Med 10.1111/jop.12493
TEH M and Wan HONG (2016). Independent Evaluation of a FOXM1-based Quantitative Malignancy Diagnostic System (qMIDS) on Head and Neck Squamous Cell Carcinomas. Impact Journals Oncotarget vol. 7, (34) 54555-54563. 10.18632/oncotarget.10512
TEH M (2016). Oral Cancer Biomarkers: Is it a Meaningless Game?, Editors: TEH M. Openventio Dentistry Open Journal vol. 3, (1) e1-e3. 10.17140/DOJ-3-e005
2015
Parker MO, Brock AJ, Sudwarts A, Teh M-T, Combe FJ and Brennan CH (2015). Developmental role of acetylcholinesterase in impulse control in zebrafish. Frontiers Frontiers in Behavioral Neuroscience vol. 9, 10.3389/fnbeh.2015.00271
Sapkota D, Bruland O, Parajuli H, Osman TA, Teh M-T, Johannessen AC and Costea DE (2015). S100A16 promotes differentiation and contributes to a less aggressive tumor phenotype in oral squamous cell carcinoma. Springer Nature Bmc Cancer vol. 15, (1) 10.1186/s12885-015-1622-1
TEH M (2015). Is Salivary Exosome the Answer to Early Detection of Oral Cancer? Openventio Publishers Dentistry Open Journal vol. 2, (2) e3-e4. 10.17140/DOJ-2-e002
Teh M-T (2015). Can Challenges of Oral Cancer Diagnosis be Resolved? Omics International Dental Health Current Research vol. 01, (01) 10.4172/2470-0886.1000e103
2014
Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh MT and Brennan CH (2014). The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development. Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 55, 94-100. 10.1016/j.pnpbp.2014.03.011
Parker MO, Evans AM-D, Brock AJ, Combe FJ, Teh M-T and Brennan CH (2014). PNE and habit. Wiley Addiction Biology vol. 21, (1) 49-60. 10.1111/adb.12176
Schmidt BL, Kuczynski J, Bhattacharya A, Huey B, Corby PM, Queiroz ELS, Nightingale K, Kerr AR, DeLacure MD, Veeramachaneni R, Olshen AB and Albertson DG (2014). Changes in Abundance of Oral Microbiota Associated with Oral Cancer. Public Library of Science (Plos) Plos One vol. 9, (6) 10.1371/journal.pone.0098741
Parker MO, Annan LV, Kanellopoulos AH, Brock AJ, Combe FJ, Baiamonte M, Teh M-T and Brennan CH (2014). The utility of zebrafish to study the mechanisms by which ethanol affects social behavior and anxiety during early brain development. Elsevier Progress in Neuro-Psychopharmacology and Biological Psychiatry vol. 55, 94-100. 10.1016/j.pnpbp.2014.03.011
Pantazi E, Gemenetzidis E, Trigiante G, Warnes G, Shan L, Mao X, Ikram M, Teh M-T, Lu Y-J and Philpott MP (2014). GLI2 induces genomic instability in human keratinocytes by inhibiting apoptosis. Cell Death Dis vol. 5, (1) 10.1038/cddis.2013.535
2013
Hwang S, Mahadevan S, Qadir F, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Waseem A and Teh M-T (2013). Identification of FOXM1-induced epigenetic markers for head and neck squamous cell carcinomas. Cancer vol. 119, (24) 4249-4258. 10.1002/cncr.28354
Bose A, Teh M-T, Mackenzie IC and Waseem A (2013). Keratin K15 as a Biomarker of Epidermal Stem Cells. Mdpi International Journal of Molecular Sciences vol. 14, (10) 19385-19398. 10.3390/ijms141019385
Teh M-T, Hutchison IL, Costea DE, Neppelberg E, Liavaag PG, Purdie K, Harwood C, Wan H, Odell EW, Hackshaw A and Waseem A (2013). Exploiting FOXM1-orchestrated molecular network for early squamous cell carcinoma diagnosis and prognosis. Int J Cancer vol. 132, (9) 2095-2106. 10.1002/ijc.27886
2012
Teh M-T (2012). Cells brainwashed by FOXM1: do they have potential as biomarkers of cancer? Biomark Med vol. 6, (4) 499-501. 10.2217/bmm.12.33
Pitiyage GN, Lim KP, Gemenitzidis E, Teh M, Waseem A, Prime SS, Tilakaratne WM, Fortune F and Parkinson EK (2012). Increased secretion of tissue inhibitors of metalloproteinases 1 and 2 (TIMPs ‐1 and ‐2) in fibroblasts are early indictors of oral sub‐mucous fibrosis and ageing. Wiley Journal of Oral Pathology and Medicine vol. 41, (6) 454-462. 10.1111/j.1600-0714.2012.01129.x
Teh M-T, Gemenetzidis E, Patel D, Tariq R, Nadir A, Bahta AW, Waseem A and Hutchison IL (2012). FOXM1 induces a global methylation signature that mimics the cancer epigenome in head and neck squamous cell carcinoma. Plos One vol. 7, (3) 10.1371/journal.pone.0034329
Bose A, Teh M-T, Hutchison IL, Wan H, Leigh IM and Waseem A (2012). Two mechanisms regulate keratin K15 expression in keratinocytes: role of PKC/AP-1 and FOXM1 mediated signalling. Plos One vol. 7, (6) 10.1371/journal.pone.0038599
Teh M-T (2012). FOXM1 coming of age: time for translation into clinical benefits? Front Oncol vol. 2, 10.3389/fonc.2012.00146
2011
TEH M (2011). Chapter 14: Initiation of Human Tumourigenesis: Upregulation of FOXM1 Transcription Factor. Stem Cells and Cancer Stem Cells,Volume 3 , Editors: Hayat MA. Springer Verlag
Teh M-T (2011). Initiation of Human Tumourigenesis: Upregulation of FOXM1 Transcription Factor. Stem Cells and Cancer Stem Cells,Volume 3 Springer Nature 10.1007/978-94-007-2415-0_14
(2011). Correction: Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. American Association For Cancer Research (Aacr) Cancer Research vol. 71, (1) 290-290. 10.1158/0008-5472.can-10-4082
Teh M-T, Parkinson EK, Thurlow JK, Liu F, Fortune F and Wan H (2011). A molecular study of desmosomes identifies a desmoglein isoform switch in head and neck squamous cell carcinoma. J Oral Pathol Med vol. 40, (1) 67-76. 10.1111/j.1600-0714.2010.00951.x
2010
Gemenetzidis E, Costea DE, Parkinson EK, Waseem A, Wan H and Teh MT (2010). Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. American Association For Cancer Research Cancer Research vol. 22, (70) 9515-9526. 10.1158/0008-5472.CAN-10-2173
Waseem A, Ali M, Odell EW, Fortune F and Teh M-T (2010). Downstream targets of FOXM1: CEP55 and HELLS are cancer progression markers of head and neck squamous cell carcinoma. Oral Oncol vol. 46, (7) 536-542. 10.1016/j.oraloncology.2010.03.022
Wang HX, Teh MT, Ji YM, Patel V, Firouzabadian S, Patel AA, Gutkind JS and Yeudall WA (2010). EPS8 upregulates FOXM1 expression, enhancing cell growth and motility. Carcinogenesis vol. 31, (6) 1132-1141. 10.1093/carcin/bgq058
Teh M-T, Gemenetzidis E, Chaplin T, Young BD and Philpott MP (2010). Upregulation of FOXM1 induces genomic instability in human epidermal keratinocytes. Mol Cancer vol. 9, 10.1186/1476-4598-9-45
Gemenetzidis E, Elena-Costea D, Parkinson EK, Waseem A, Wan H and Teh MT (2010). Induction of Human Epithelial Stem/Progenitor Expansion by FOXM1. American Association For Cancer Research. Cancer Research vol. 70, (22) 9515-9526. 10.1158/0008-5472.CAN-10-2173
Tsang SM, Liu L, Teh M-T, Wheeler A, Grose R, Hart IR, Garrod DR, Fortune F and Wan H (2010). Desmoglein 3, via an interaction with E-cadherin, is associated with activation of Src. Plosone Plos One vol. 5, (12) 10.1371/journal.pone.0014211
2009
Gemenetzidis E, Bose A, Riaz AM, Chaplin T, Young BD, Ali M, Sugden D, Thurlow JK, Cheong S-C, Teo S-H, Wan H, Waseem A, Parkinson EK, Fortune F and Teh M-T (2009). FOXM1 upregulation is an early event in human squamous cell carcinoma and it is enhanced by nicotine during malignant transformation. Plos One vol. 4, (3) 10.1371/journal.pone.0004849
2008
Teh MT, Tilakaratne WM, Chaplin T, Young BD, Ariyawardana A, Pitiyage G, Lalli A, Stewart JE, Hagi-Pavli E, Cruchley A, Waseem A and Fortune F (2008). Fingerprinting genomic instability in oral submucous fibrosis. J Oral Pathol Med vol. 37, (7) 430-436. 10.1111/j.1600-0714.2008.00643.x
Tilakaratne WM, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Stewart JE, Hagi-Pavli E, Lalli A, Waseem A, Parkinson EK and Fortune F (2008). Upregulation of HIF-1 alpha in malignant transformation of oral submucous fibrosis. J Oral Pathol Med vol. 37, (6) 372-377. 10.1111/j.1600-0714.2007.00625.x
Lalli A, Tilakaratne WM, Ariyawardana A, Fitchett C, Leigh IM, Hagi-Pavli E, Cruchley AT, Parkinson EK, Teh MT, Fortune F and Waseem A (2008). An altered keratinocyte phenotype in oral submucous fibrosis: correlation of keratin K17 expression with disease severity. J Oral Pathol Med vol. 37, (4) 211-220. 10.1111/j.1600-0714.2007.00609.x
2007
Purdie KJ, Lambert SR, Teh M-T, Chaplin T, Molloy G, Raghavan M, Kelsell DP, Leigh IM, Harwood CA, Proby CM and Young BD (2007). Allelic imbalances and microdeletions affecting the PTPRD gene in cutaneous squamous cell carcinomas detected using single nucleotide polymorphism microarray analysis. Genes Chromosomes Cancer vol. 46, (7) 661-669. 10.1002/gcc.20447
Faust R, Garratt PJ, Perez MAT, Piccio VJD, Madsen C, Stenstrom A, Frolund B, Davidson K, Teh MT and Sugden D (2007). 7-Substituted-melatonin and 7-substituted-1-methylmelatonin analogues: Effect of substituents on potency and binding affinity. Bioorgan Med Chem vol. 15, (13) 4543-4551. 10.1016/j.bmc.2007.04.013
Tilakaratne W, Iqbal Z, Teh MT, Ariyawardana A, Pitiyage G, Cruchley A, Hagi-Pavli E, Lalli A, Waseem A, Parkinson K and Fortune F (2007). P245 Up regulation of HIF-1a in the progression and malignant transformation of oral submucous fibrosis. Elsevier Oral Oncology Supplement vol. 2, (1) 204-205. 10.1016/s1744-7895(07)70522-9
Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP and Philpott MP (2007). Erratum: Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (Journal of Cell Science vol. 120 (330-339)). Journal of Cell Science vol. 120, (5) 10.1242/jcs.03421
Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP and Philpott MP (2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (vol 120, pg 330, 2007). J Cell Sci vol. 120, (5) 917-917. 10.1242/jcs.03329
Teh M-T, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP and Philpott MP (2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci vol. 120, (Pt 2) 330-339. 10.1242/jcs.03329
2006
Blaydon DC, Ishii Y, O'Toole EA, Unsworth HC, Teh M-T, Rüschendorf F, Sinclair C, Hopsu-Havu VK, Tidman N, Moss C, Watson R, de Berker D, Wajid M, Christiano AM and Kelsell DP (2006). The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nat Genet vol. 38, (11) 1245-1247. 10.1038/ng1883
Tsotinis A, Vlachou M, Papahatjis DP, Calogeropoulou T, Nikas SP, Garratt PJ, Piccio V, Vonhoff S, Davidson K, Teh MT and Sugden D (2006). Mapping the melatonin receptor. 7. Subtype selective ligands based on beta-substituted N-acyl-5-methoxytryptamines and beta-substituted N-acyl-5-methoxy-1-methyltryptamines. J Med Chem vol. 49, (12) 3509-3519. 10.1021/jm0512544
2005
Teh M-T, Blaydon D, Chaplin T, Foot NJ, Skoulakis S, Raghavan M, Harwood CA, Proby CM, Philpott MP, Young BD and Kelsell DP (2005). Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event. Cancer Res vol. 65, (19) 8597-8603. 10.1158/0008-5472.CAN-05-0842
Kelsell DP, Norgett EE, Unsworth H, Teh M-T, Cullup T, Mein CA, Dopping-Hepenstal PJ, Dale BA, Tadini G, Fleckman P, Stephens KG, Sybert VP, Mallory SB, North BV, Witt DR, Sprecher E, Taylor AEM, Ilchyshyn A, Kennedy CT, Goodyear H, Moss C, Paige D, Harper JI, Young BD, Leigh IM, Eady RAJ and O'Toole EA (2005). Mutations in ABCA12 underlie the severe congenital skin disease harlequin ichthyosis. Am J Hum Genet vol. 76, (5) 794-803. 10.1086/429844
2004
Sugden D, Davidson K, Hough KA and Teh M-T (2004). Melatonin, melatonin receptors and melanophores: a moving story. Pigment Cell Res vol. 17, (5) 454-460. 10.1111/j.1600-0749.2004.00185.x
Davies DJ, Faust R, Garratt PJ, Marivingt-Mounir C, Davidson K, Teh MT and Sugden D (2004). Binding affinity and biological activity of oxygen and sulfur isosteres at melatonin receptors as a function of their hydrogen bonding capability. Bioorg Chem vol. 32, (1) 1-12. 10.1016/j.bioorg.2003.09.004
2002
Teh M-T, Wong S-T, Neill GW, Ghali LR, Philpott MP and Quinn AG (2002). FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res vol. 62, (16) 4773-4780.
Philpott MP, NEILL GW, Leigh IM, Quinn AG, Ghali LR, Wong ST and Teh MT (2002). FOXM1 is a downstream target of Gli1 in basal cell carcinomas. Cancer Res. vol. 62, (16) 4773-4780.
Teh M-T and Sugden D (2002). Desensitization of pigment granule aggregation in Xenopus leavis melanophores: melatonin degradation rather than receptor down-regulation is responsible. J Neurochem vol. 81, (4) 719-727. 10.1046/j.1471-4159.2002.00885.x
2001
Teh MT and Sugden D (2001). An endogenous 5-HT7 receptor mediates pigment granule dispersion in Xenopus laevis melanophores. Brit J Pharmacol vol. 132, (8) 1799-1808. 10.1038/sj.bjp.0703988
2000
Teh MT (2000). Cellular and Molecular Studies on Pigment-Granule Translocation in Xenopus Melanophores., Editors: Sugden DD.
Faust R, Garratt PJ, Jones R, Yeh LK, Tsotinis A, Panoussopoulou M, Calogeropoulou T, Teh MT and Sugden D (2000). Mapping the melatonin receptor. 6. Melatonin agonists and antagonists derived from 6H-isoindolo[2,1-a]indoles, 5,6-dihydroindolo[2,1-a]isoquinolines, and 6,7-dihydro-5H-benzo[c]azepino[2,1-a]indoles. J Med Chem vol. 43, (6) 1050-1061. 10.1021/jm980684+
1999
Li PK, Sugden D, Teh MT, Chu GH and Witt-Enderby PA (1999). Synthesis and studies of irreversible melatonin receptor ligands. Abstr Pap Am Chem S vol. 218, U962-U962.
Teh MT and Sugden D (1999). The putative melatonin receptor antagonist GR128107 is a partial agonist on Xenopus laevis melanophores. Brit J Pharmacol vol. 126, (5) 1237-1245. 10.1038/sj.bjp.0702404
1998
Teh MT and Sugden D (1998). GR128107 is a partial melatonin receptor agonist on Xenopus laevis melanophores. Brit J Pharmacol vol. 125, U39-U39.
Teh MT and Sugden D (1998). Comparison of the structure-activity relationships of melatonin receptor agonists and antagonists: Lengthening the N-acyl side-chain has differing effects on potency on Xenopus melanophores. N-S Arch Pharmacol vol. 358, (5) 522-528. 10.1007/pl00005288
Davies DJ, Garratt PJ, Tocher DA, Vonhoff S, Davies J, Teh MT and Sugden D (1998). Mapping the melatonin receptor. 5. Melatonin agonists and antagonists derived from tetrahydrocyclopent[b]indoles, tetrahydrocarbazoles and hexahydrocyclohept[b]indoles. J Med Chem vol. 41, (4) 451-467. 10.1021/jm970246n
Grants
Development and validation of a molecular diagnostic tool for early diagnostic and personalized treatment of oral cancer
Costea DE, Mohamed NGA, Mohamed NMG, Nginamau ES, Suleiman A, Almahdi H, Uhlin-Hansen L, Dongre H, Jacobsen MR, Calenic B, Parajuli H, Sawant S, Muy-Teck T, Vaidya M, Johannessen AC, Neppelberg E, Sapkota D, Osman TA-H, Rajthala S, ahmed I and Teh M-T
Western Norway Regional Health Authority (01-01-2014 - 31-12-2016)
Costea DE, Mohamed NGA, Mohamed NMG, Nginamau ES, Suleiman A, Almahdi H, Uhlin-Hansen L, Dongre H, Jacobsen MR, Calenic B, Parajuli H, Sawant S, Muy-Teck T, Vaidya M, Johannessen AC, Neppelberg E, Sapkota D, Osman TA-H, Rajthala S, ahmed I and Teh M-T
Western Norway Regional Health Authority (01-01-2014 - 31-12-2016)