Dr Marc Fernandez-Yague
Lecturer in Chemistry
School of Physical and Chemical Sciences
Queen Mary University of London
Queen Mary University of London
Research
Biomaterials, Mechanobiology, Regenerative Medicine, Bioelectricty, Immunoengineering, Cell-Matrix interactions
Interests
Designing immunomodulatory therapies requires a precise understanding of immune cell formation and activation in various immune organs. Traditional in vivo approaches are difficult to control, and in vitro models often lack physiological relevance. My lab develops immune organoid models using synthetic materials that mimic immune tissues' structure and function, enabling the investigation of immune function/dysfunction at the cell, tissue, and organ levels.Lymph Organoid: We generate antibody-secreting cells from young and aged patients to elucidate the role of epigenetic modifiers (EZH2, DNMT3A, HDAC) in immune responses in tissue repair diseases.
Immunity-Reprogramming Models: We explore molecular technologies to modulate Treg cell function and differentiation against biomaterials for treating tissue repair diseases.
Publications
2024
A Tympanic Piezo‐Bioreactor Modulates Ion Channel‐Associated Mechanosignaling to Stabilize Phenotype and Promote Tenogenesis in Human Tendon‐Derived Cells.Fernandez‐Yague MA, Palma M, Tofail SAM, Duffy M, Quinlan LR, Dalby MJ, Pandit A, Biggs MJ
Advanced Science, Wiley vol. 11 (45)
22-10-2024
FAK, vinculin, and talin control mechanosensitive YAP nuclear localizationHolland EN, Fernández-Yagüe MA, Zhou DW, O'Neill EB, Woodfolk AU, Mora-Boza A, Fu J, Schlaepfer DD et al.
Biomaterials, Elsevier vol. 308
20-03-2024
2022
Adhesive peptide and polymer density modulate 3D cell traction forces within synthetic hydrogelsColasurdo M, Nieves EB, Fernández-Yagüe MA, Franck C, García AJ
Biomaterials, Elsevier vol. 288
11-08-2022
A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion ChannelsFernandez-Yague MA, Trotier A, Demir S, Abbah SA, Larrañaga A, Stapleton A, Palma M
Advanced Materials, Wiley vol. 34 (14)
01-04-2022
Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsetsFernandez-Yague MA, Hymel LA, Olingy CE, McClain C, Ogle ME, García JR, Minshew D, Vyshnya S et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 8 (8)
25-02-2022
2021
A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels (Adv. Mater. 40/2021)Fernandez‐Yague MA, Trotier A, Demir S, Abbah SA, Larrañaga A, Thirumaran A, Stapleton A, Tofail SAM et al.
Advanced Materials, Wiley vol. 33 (40)
01-10-2021
A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion ChannelsFernandez‐Yague MA, Trotier A, Demir S, Abbah SA, Larrañaga A, Thirumaran A, Stapleton A, Tofail SAM et al.
Advanced Materials, Wiley vol. 33 (40)
23-08-2021
Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repairZhou DW, Fernández-Yagüe MA, Holland EN, García AF, Castro NS, O’Neill EB, Eyckmans J, Chen CS et al.
Nature Communications, Springer Nature vol. 12 (1)
21-04-2021
In vitro analysis of a physiological strain sensor formulated from a PEDOT:PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) compositeTadayyon G, Krukiewicz K, Britton J, Larrañaga A, Vallejo-Giraldo C, Fernandez-Yague M, Guo Y, Orpella-Aceret G et al.
Materials Science and Engineering C, Elsevier vol. 121
06-01-2021
2020
Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three-Dimensional Bone Tissue Engineering.Orapiriyakul W, Tsimbouri MP, Childs P, Campsie P, Wells J, Fernandez-Yague MA, Burgess K, Tanner KE et al.
Acs Nano, American Chemical Society
23-07-2020
Pancreatic Islets: Functionalization of Alginate with Extracellular Matrix Peptides Enhances Viability and Function of Encapsulated Porcine Islets (Adv. Healthcare Mater. 9/2020)Medina JD, Alexander M, Hunckler MD, Fernández‐Yagüe MA, Coronel MM, Smink AM
Advanced Healthcare Materials, Wiley vol. 9 (9)
01-05-2020
Functionalization of Alginate with Extracellular Matrix Peptides Enhances Viability and Function of Encapsulated Porcine IsletsMedina JD, Alexander M, Hunckler MD, Fernández‐Yagüe MA, Coronel MM, Smink AM, Lakey JR, de Vos P et al.
Advanced Healthcare Materials, Wiley vol. 9 (9)
07-04-2020
2019
Boron Nitride Nanotube Addition Enhances the Crystallinity and Cytocompatibility of PVDF-TrFEPoudel A, Fernandez MA, Tofail SAM, Biggs MJP
Frontiers in Chemistry, Frontiers vol. 7
21-05-2019
Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methodsFernández-Yagüe M, Antoñanzas RP, Biggs M, Gil FJ
Nanomedicine Nanotechnology Biology and Medicine, Elsevier vol. 18, 1-10.
26-02-2019
2018
In vivo efficiency of antimicrobial inorganic bone grafts in osteomyelitis treatmentsMestres G, Fernandez-Yague MA, Pastorino D, Montufar EB, Canal C, Manzanares-Céspedes MC, Ginebra MP
Materials Science and Engineering C, Elsevier vol. 97, 84-95.
28-11-2018
Attenuated Glial Reactivity on Topographically Functionalized Poly(3,4-Ethylenedioxythiophene):P-Toluene Sulfonate (PEDOT:PTS) Neuroelectrodes Fabricated by Microimprint Lithography.Vallejo-Giraldo C, Krukiewicz K, Calaresu I, Zhu J, Palma M, Fernandez-Yague M, McDowell B, Peixoto N et al.
Small vol. 14 (28), e1800863-e1800863.
01-07-2018
2017
Antioxidant functionalized polymer capsules to prevent oxidative stressLarrañaga A, Isa ILM, Patil V, Thamboo S, Lomora M, Fernández-Yague MA, Sarasua J-R, Palivan CG et al.
Acta Biomaterialia, Elsevier vol. 67, 21-31.
16-12-2017
Direct Laser Interference Patterning of CoCr Alloy Surfaces to Control Endothelial Cell and Platelet Response for Cardiovascular ApplicationsSchieber R, Lasserre F, Hans M, Fernández‐Yagüe M, Díaz‐Ricart M, Escolar G, Ginebra M, Mücklich F et al.
Advanced Healthcare Materials, Wiley vol. 6 (19)
17-07-2017
2016
Effects of isothermal crystallization on the mechanical properties of a elastomeric medium chain length polyhydroxyalkanoateLarrañaga A, Pompanon F, Gruffat N, Palomares T, Alonso-Varona A, Varga AL, Fernandez-Yague MA, Biggs MJP et al.
European Polymer Journal, Elsevier vol. 85, 401-410.
01-12-2016
Polyhydroxyalkanoate/carbon nanotube nanocomposites: flexible electrically conducting elastomers for neural applicationsVallejo-Giraldo C, Pugliese E, Larraaga A, Fernandez-Yague MA, Britton JJ, Trotier A, Tadayyon G, Kelly A et al.
Nanomedicine, Taylor & Francis vol. 11 (19), 2547-2563.
13-09-2016
Biological Activity on Piezoelectric PVDFFernandez-Yague MA, Vallejo-Giraldo C, Aceret GO, Biggs MJ
In Electrically Active Materials For Medical Devices, World Scientific Publishing 167-176.
08-08-2016
2015
Effects of Polydopamine Functionalization on Boron Nitride Nanotube Dispersion and CytocompatibilityFernandez-Yague MA, Larrañaga A, Gladkovskaya O, Stanley A, Tadayyon G, Guo Y, Sarasua J-R, Tofail SAM et al.
Bioconjugate Chemistry, American Chemical Society (Acs) vol. 26 (10), 2025-2037.
15-09-2015
Determination of fluid leakages in the different screw-retained implant-abutment connections in a mechanical artificial mouthMartin-Gili D, Molmeneu M, Fernandez M, Punset M, Armengou J
Journal of Materials Science: Materials in Medicine, Springer Nature vol. 26 (7)
01-07-2015
Nanoscale neuroelectrode modification via sub-20 nm silicon nanowires through self-assembly of block copolymersMokarian-Tabari P, Vallejo-Giraldo C, Fernandez-Yague M, Cummins C, Morris MA, Biggs MJP
Journal of Materials Science: Materials in Medicine, Springer Nature vol. 26 (2)
01-02-2015
Advances in surfaces and osseointegration in implantology. Biomimetic surfacesAlbertini M, Fernandez-Yague M, Lázaro P, Herrero-Climent M, Rios-Santos J-V, Bullon P, Gil F-J
Medicina Oral Patología Oral Y Cirugia Bucal, Medicina Oral, S.L. vol. 20 (3), e316-e325.
01-01-2015
2014
Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategiesFernandez-Yague MA, Abbah SA, McNamara L, Zeugolis DI, Pandit A, Biggs MJ
Advanced Drug Delivery Reviews, Elsevier vol. 84, 1-29.
16-09-2014
2013
Analysis of the misfit of dental implant-supported prostheses made with three manufacturing processesFernández M, Delgado L, Molmeneu M, García D, Rodríguez D
Journal of Prosthetic Dentistry, Elsevier vol. 111 (2), 116-123.
28-10-2013
Self-powered piezo-bioelectronic device mediates tendon repair through modulation of mechanosensitive ion channelsFernandez-Yague MA, Trotier A, Abbah SA, Larrañaga A, Thirumaran A, Stapleton A, Tofail SAM, Palma M et al.
In Biorxiv
Force-FAK Signaling Coupling at Individual Focal Adhesions Coordinates Mechanosensing and Microtissue RepairZhou D, Fernández-Yagüe M, Holland E, García A, Castro N, O’Neill E, Eyckmans J, Chen C et al.
In Research Square
Nanovibrational stimulation of mesenchymal stem cells induces therapeutic reactive oxygen species and inflammation for 3D bone tissue engineeringOrapiriyakul W, Tsimbouri PM, Childs PG, Campsie P, Wells J, Fernandez-Yague M, Burgess K, Tanner KE et al.
In Biorxiv
Grants
Precision Mechano-Therapeutics With Light-Driven Molecular Nanomachines Against Progressive FibrosisMarc Fernandez-Yague
£19,926 Royal Society
01-10-2024 - 30-09-2025