Dr Marc Fernandez-Yague
Lecturer in Chemistry
Research
Biomaterials, Mechanobiology, Regenerative Medicine, Bioelectricty, Immunoengineering, Cell-Matrix interactions
Interests
Designing immunomodulatory therapies requires a precise understanding of immune cell formation and activation in various immune organs. Traditional in vivo approaches are difficult to control, and in vitro models often lack physiological relevance. My lab develops immune organoid models using synthetic materials that mimic immune tissues' structure and function, enabling the investigation of immune function/dysfunction at the cell, tissue, and organ levels. Lymph Organoid: We generate antibody-secreting cells from young and aged patients to elucidate the role of epigenetic modifiers (EZH2, DNMT3A, HDAC) in immune responses in tissue repair diseases. Immunity-Reprogramming Models: We explore molecular technologies to modulate Treg cell function and differentiation against biomaterials for treating tissue repair diseases.Publications
Publications of specific relevance to Predictive in vitro Models2024
Holland EN, Fernández-Yagüe MA, Zhou DW, O'Neill EB, Woodfolk AU, Mora-Boza A, Fu J, Schlaepfer DD and García AJ (2024). FAK, vinculin, and talin control mechanosensitive YAP nuclear localization. Elsevier Biomaterials vol. 308, 10.1016/j.biomaterials.2024.1225422022
Colasurdo M, Nieves EB, Fernández-Yagüe MA, Franck C and García AJ (2022). Adhesive peptide and polymer density modulate 3D cell traction forces within synthetic hydrogels. Elsevier Biomaterials vol. 288, 10.1016/j.biomaterials.2022.121710Fernandez-Yague MA, Trotier A, Demir S, Abbah SA, Larrañaga A, Thirumaran A, Stapleton A, Tofail SAM, Palma M, Kilcoyne M, Pandit A and Biggs MJ (2022). A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels. Wiley Advanced Materials vol. 34, (14) 10.1002/adma.202201543Fernandez-Yague MA, Hymel LA, Olingy CE, McClain C, Ogle ME, García JR, Minshew D, Vyshnya S, Lim HS, Qiu P, García AJ and Botchwey EA (2022). Analyzing immune response to engineered hydrogels by hierarchical clustering of inflammatory cell subsets. American Association For The Advancement of Science (Aaas) Science Advances vol. 8, (8) 10.1126/sciadv.abd80562021
Fernandez‐Yague MA, Trotier A, Demir S, Abbah SA, Larrañaga A, Thirumaran A, Stapleton A, Tofail SAM, Palma M, Kilcoyne M, Pandit A and Biggs MJ (2021). A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels (Adv. Mater. 40/2021). Wiley Advanced Materials vol. 33, (40) 10.1002/adma.202170315Fernandez‐Yague MA, Trotier A, Demir S, Abbah SA, Larrañaga A, Thirumaran A, Stapleton A, Tofail SAM, Palma M, Kilcoyne M, Pandit A and Biggs MJ (2021). A Self‐Powered Piezo‐Bioelectric Device Regulates Tendon Repair‐Associated Signaling Pathways through Modulation of Mechanosensitive Ion Channels. Wiley Advanced Materials vol. 33, (40) 10.1002/adma.202008788Zhou DW, Fernández-Yagüe MA, Holland EN, García AF, Castro NS, O’Neill EB, Eyckmans J, Chen CS, Fu J, Schlaepfer DD and García AJ (2021). Force-FAK signaling coupling at individual focal adhesions coordinates mechanosensing and microtissue repair. Springer Nature Nature Communications vol. 12, (1) 10.1038/s41467-021-22602-5Tadayyon G, Krukiewicz K, Britton J, Larrañaga A, Vallejo-Giraldo C, Fernandez-Yague M, Guo Y, Orpella-Aceret G, Li L, Poudel A and Biggs MJP (2021). In vitro analysis of a physiological strain sensor formulated from a PEDOT:PSS functionalized carbon nanotube-poly(glycerol sebacate urethane) composite. Elsevier Materials Science and Engineering C vol. 121, 10.1016/j.msec.2020.1118572020
Orapiriyakul W, Tsimbouri MP, Childs P, Campsie P, Wells J, Fernandez-Yague MA, Burgess K, Tanner KE, Tassieri M, Meek D, Vassalli M, Biggs MJP, Salmeron-Sanchez M, Oreffo ROC, Reid S and Dalby MJ (2020). Nanovibrational Stimulation of Mesenchymal Stem Cells Induces Therapeutic Reactive Oxygen Species and Inflammation for Three-Dimensional Bone Tissue Engineering. American Chemical Society Acs Nano 10.1021/acsnano.0c03130Medina JD, Alexander M, Hunckler MD, Fernández‐Yagüe MA, Coronel MM, Smink AM, Lakey JR, de Vos P and García AJ (2020). Pancreatic Islets: Functionalization of Alginate with Extracellular Matrix Peptides Enhances Viability and Function of Encapsulated Porcine Islets (Adv. Healthcare Mater. 9/2020). Wiley Advanced Healthcare Materials vol. 9, (9) 10.1002/adhm.202070025Medina JD, Alexander M, Hunckler MD, Fernández‐Yagüe MA, Coronel MM, Smink AM, Lakey JR, de Vos P and García AJ (2020). Functionalization of Alginate with Extracellular Matrix Peptides Enhances Viability and Function of Encapsulated Porcine Islets. Wiley Advanced Healthcare Materials vol. 9, (9) 10.1002/adhm.2020001022019
Poudel A, Fernandez MA, Tofail SAM and Biggs MJP (2019). Boron Nitride Nanotube Addition Enhances the Crystallinity and Cytocompatibility of PVDF-TrFE. Frontiers Frontiers in Chemistry vol. 7, 10.3389/fchem.2019.00364Fernández-Yagüe M, Antoñanzas RP, Roa JJ, Biggs M, Gil FJ and Pegueroles M (2019). Enhanced osteoconductivity on electrically charged titanium implants treated by physicochemical surface modifications methods. Elsevier Nanomedicine Nanotechnology Biology and Medicine vol. 18, 1-10. 10.1016/j.nano.2019.02.0052018
Mestres G, Fernandez-Yague MA, Pastorino D, Montufar EB, Canal C, Manzanares-Céspedes MC and Ginebra MP (2018). In vivo efficiency of antimicrobial inorganic bone grafts in osteomyelitis treatments. Elsevier Materials Science and Engineering C vol. 97, 84-95. 10.1016/j.msec.2018.11.064Vallejo-Giraldo C, Krukiewicz K, Calaresu I, Zhu J, Palma M, Fernandez-Yague M, McDowell B, Peixoto N, Farid N, O'Connor G, Ballerini L, Pandit A and Biggs MJP (2018). Attenuated Glial Reactivity on Topographically Functionalized Poly(3,4-Ethylenedioxythiophene):P-Toluene Sulfonate (PEDOT:PTS) Neuroelectrodes Fabricated by Microimprint Lithography. Small vol. 14, (28) e1800863-e1800863. 10.1002/smll.2018008632017
Larrañaga A, Isa ILM, Patil V, Thamboo S, Lomora M, Fernández-Yague MA, Sarasua J-R, Palivan CG and Pandit A (2017). Antioxidant functionalized polymer capsules to prevent oxidative stress. Elsevier Acta Biomaterialia vol. 67, 21-31. 10.1016/j.actbio.2017.12.014Schieber R, Lasserre F, Hans M, Fernández‐Yagüe M, Díaz‐Ricart M, Escolar G, Ginebra M, Mücklich F and Pegueroles M (2017). Direct Laser Interference Patterning of CoCr Alloy Surfaces to Control Endothelial Cell and Platelet Response for Cardiovascular Applications. Wiley Advanced Healthcare Materials vol. 6, (19) 10.1002/adhm.2017003272016
Larrañaga A, Pompanon F, Gruffat N, Palomares T, Alonso-Varona A, Varga AL, Fernandez-Yague MA, Biggs MJP and Sarasua JR (2016). Effects of isothermal crystallization on the mechanical properties of a elastomeric medium chain length polyhydroxyalkanoate. Elsevier European Polymer Journal vol. 85, 401-410. 10.1016/j.eurpolymj.2016.10.050Vallejo-Giraldo C, Pugliese E, Larraaga A, Fernandez-Yague MA, Britton JJ, Trotier A, Tadayyon G, Kelly A, Rago I, Sarasua J-R, Dowd E, Quinlan LR, Pandit A and Biggs MJ (2016). Polyhydroxyalkanoate/carbon nanotube nanocomposites: flexible electrically conducting elastomers for neural applications. Taylor & Francis Nanomedicine vol. 11, (19) 2547-2563. 10.2217/nnm-2016-0075Fernandez-Yague MA, Vallejo-Giraldo C, Aceret GO, Pandit A and Biggs MJ (2016). Biological Activity on Piezoelectric PVDF. Electrically Active Materials For Medical Devices World Scientific Publishing 10.1142/9781783269877_00122015
Fernandez-Yague MA, Larrañaga A, Gladkovskaya O, Stanley A, Tadayyon G, Guo Y, Sarasua J-R, Tofail SAM, Zeugolis DI, Pandit A and Biggs MJ (2015). Effects of Polydopamine Functionalization on Boron Nitride Nanotube Dispersion and Cytocompatibility. American Chemical Society (Acs) Bioconjugate Chemistry vol. 26, (10) 2025-2037. 10.1021/acs.bioconjchem.5b00257Martin-Gili D, Molmeneu M, Fernandez M, Punset M, Giner L, Armengou J and Gil FJ (2015). Determination of fluid leakages in the different screw-retained implant-abutment connections in a mechanical artificial mouth. Springer Nature Journal of Materials Science: Materials in Medicine vol. 26, (7) 10.1007/s10856-015-5544-xMokarian-Tabari P, Vallejo-Giraldo C, Fernandez-Yague M, Cummins C, Morris MA and Biggs MJP (2015). Nanoscale neuroelectrode modification via sub-20 nm silicon nanowires through self-assembly of block copolymers. Springer Nature Journal of Materials Science: Materials in Medicine vol. 26, (2) 10.1007/s10856-015-5426-2Albertini M, Fernandez-Yague M, Lázaro P, Herrero-Climent M, Rios-Santos J-V, Bullon P and Gil F-J (2015). Advances in surfaces and osseointegration in implantology. Biomimetic surfaces. Medicina Oral, S.L. Medicina Oral Patología Oral Y Cirugia Bucal vol. 20, (3) e316-e325. 10.4317/medoral.203532014
Fernandez-Yague MA, Abbah SA, McNamara L, Zeugolis DI, Pandit A and Biggs MJ (2014). Biomimetic approaches in bone tissue engineering: Integrating biological and physicomechanical strategies. Elsevier Advanced Drug Delivery Reviews vol. 84, 1-29. 10.1016/j.addr.2014.09.0052013
Fernández M, Delgado L, Molmeneu M, García D and Rodríguez D (2013). Analysis of the misfit of dental implant-supported prostheses made with three manufacturing processes. Elsevier Journal of Prosthetic Dentistry vol. 111, (2) 116-123. 10.1016/j.prosdent.2013.09.006