Dr Matthew Caley

Matthew Caley

Senior Lecturer in Cell Biology

Blizard Institute
Queen Mary University of London
07971 890473
ORCID

Research

Skin, Lipids, rare diseases, screening, Extracellular Matrix, Laminin 332

Skin Models

Interests

My research focusses on the skin basement membrane and specifically laminin 332 a three-chained glycoprotein which is copiously secreted by epithelial cells. We have demonstrated an important role for laminin 332 in skin ageing, squamous cell carcinoma invasion, cholesterol transport and in skin immune regulation.
To study these diverse functions we have generated co-culture and 3D skin models including models of aged skin that have allowed us to test gene knockdowns and drug treatments.
We have also developed and validated a high throughput screen to identify compounds altering cholesterol transport within the skin.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

0563 TRPV3 novel inhibitor KM-023 as a potential oral treatment for keratodermas
Brener E, Marchal L, Caley M, Mashriki T, McGrath M, Vaisman B, Michel D, Barak SL et al.
Journal of Investigative Dermatology, Elsevier Bv vol. 145 (8), S97-S97.  
01-08-2025
Weekly Intraperitoneal Injection of Tamoxifen in an Inducible In Vivo Model of Junctional Epidermolysis Bullosa Generates Early and Advanced Disease Phenotypes
Jones EM, Garcha P, Aumailley M, O’Toole EA, Rognoni E, Caley M
Jid Innovations, Elsevier Bv vol. 5 (2), 100331-100331.  
01-03-2025
Replicating Dynamic Immune Responses at Single‐Cell Resolution within a Microfluidic Human Skin Equivalent
Hindle SA, Bachas Brook H, Chrysanthou A, Chambers ES, Caley MP, Connelly JT
Advanced Science, Wiley vol. 12 (10) 
21-01-2025

2024

232 JAK Inhibitors to Restore Skin Barrier Function in a Mouse Model of Harlequin Ichthyosis
Giusto E, Jones E, Ahmed A, Cottle D, Smyth I, Caley M, Rognoni E, O’Toole EA
Journal of Investigative Dermatology, Elsevier Bv vol. 144 (12), S268-S268.  
01-12-2024
182 Dissecting Epidermolysis Bullosa Heterogeneity
Garcha P, Petrof G, Martinez A, McGrath JA, O’Toole EA, Rognoni E, Caley M
Journal of Investigative Dermatology, Elsevier Bv vol. 144 (12), S259-S259.  
01-12-2024
Targeting the Complexity of In Vitro Skin Models: A Review of Cutting-Edge Developments
Quílez C, Bebiano LB, Jones E, Maver U, Meesters L, Parzymies P, Petiot E, Rikken G et al.
Journal of Investigative Dermatology, Elsevier Bv vol. 144 (12), 2650-2670.  
01-12-2024
Replicating dynamic immune responses at single-cell resolution within a microfluidic human skin equivalent
Hindle SA, Brook HB, Chrysanthou A, Chambers ES, Caley MP, Connelly JT
In Cold Spring Harbor Laboratory 
17-11-2024
Erosive lichen planus: an unmet disease burden
Macken JH, Senusi A, O’Toole EA, Caley M, Rognoni E, Fortune F
Frontiers in Medicine, Frontiers Media Sa vol. 11 
17-10-2024
Lipid Nanoparticles Efficiently Deliver the Base Editor ABE8e for COL7A1 Correction in Dystrophic Epidermolysis Bullosa Fibroblasts In Vitro
Guri-Lamce I, Alrokh Y, Graham C, Maeshima R, Rognoni E, Caley M, Łaczmański Ł, Hart SL et al.
Journal of Investigative Dermatology, Elsevier Bv vol. 144 (10), 2314-2317.e3.  
01-10-2024
771 Novel TRPV3 inhibitors developed for the treatment of Palmoplantar keratodermas, demonstrate safety and efficacy in preclinical models
Idrissi M, Caley M, Aviezer D, Brener E, Mashriki T, Barak SL, Michel D, O’Toole EA et al.
Journal of Investigative Dermatology, Elsevier Bv vol. 144 (8), S135-S135.  
01-08-2024
P038 Impact of cumulative low-level ozone on keratinocytes and implications for atopic eczema pathogenesis
Tawfik S, Thomas B, Caley M, Jones E, O’Shaughnessy R, O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 191 (Supplement_1), i31-i32.  
28-06-2024
P16 Fibroblast signalling crosstalk drives junctional epidermolysis bullosa disease progression
Khan MRA, Kirk T, Caley MP, Rognoni E
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e86-e86.  
17-05-2024
P10 Janus kinase inhibitors to restore skin barrier function in a mouse model of Harlequin ichthyosis
Giusto E, Jones E, Enjalbert F, Ahmed A, Caley M, Rognoni E, O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e83-e84.  
17-05-2024
O20 Dissecting junctional epidermolysis bullosa heterogeneity
Garcha P, Jones E, Ahmed AA, Aumailley M, Rognoni E, Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e77-e78.  
17-05-2024
O19 Improvement of a junctional epidermolysis bullosa mouse model
Jones E, Garcha P, Aumailley M, O’Toole E, Rognoni E, Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e77-e77.  
17-05-2024
O08 Exploring the effect of skin ageing-related basement membrane collagen loss on nuclear mechanics
Summan S, Mayes A, Gunn D, Madapura P, Gautrot J, Caley M, O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e71-e72.  
17-05-2024

2023

Loss of cholesterol in Junctional Epidermolysis Bullosa skin identifies a key role for Laminin-332 in actomyosin mediated cholesterol transport
Jones EM, Camera E, Parzymies P, Marsh ST, O’Shaughnessy RF, Aumailley M, McGrath JA, O’Toole EA et al.
In Cold Spring Harbor Laboratory 
11-09-2023
LB1754 Treatment of human palmoplantar keratoderma skin equivalents with a TRPV3 antagonist, KM-001
Caley M, Idrissi M, Braiman L, Brener E, O'Toole E
Journal of Investigative Dermatology, Elsevier Bv vol. 143 (9), B26-B26.  
01-09-2023
P32 Restoring the ageing skin barrier in vitro
Garcha P, Jones E, Shelley J, Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e26-e27.  
07-07-2023
P16 How does skin ageing-related basement membrane collagen loss affect the nucleus?
Summan SK, Mayes A, Gunn D, Gautrot J, Caley M, O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e20-e20.  
07-07-2023
O16 The novel roles of laminin α3 in epidermal barrier function and metabolism
Parzymies P, Jones EM, Mayes A, Messenger D, O’Toole E, Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e11-e11.  
07-07-2023
O14 Junctional epidermolysis bullosa: repairing the epidermal lipid barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O’Toole E, Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e10-e10.  
07-07-2023
O13 JAK inhibitors to restore skin barrier function in ARCI
Giusto E, Enjalbert F, Rognoni E, Caley M, O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e9-e10.  
07-07-2023
Role of Enzymic Antioxidants in Mediating Oxidative Stress and Contrasting Wound Healing Capabilities in Oral Mucosal/Skin Fibroblasts and Tissues
Lohana P, Suryaprawira A, Woods EL, Dally J, Gait-Carr E, Alaidaroos NYA, Heard CM, Lee KY et al.
Antioxidants, Mdpi Ag vol. 12 (7), 1374-1374.  
30-06-2023
RNA sequencing and lipidomics uncovers novel pathomechanisms in recessive X-linked ichthyosis
McGeoghan F, Camera E, Maiellaro M, Menon M, Huang M, Dewan P, Ziaj S, Caley MP et al.
Frontiers in Molecular Biosciences, Frontiers Media Sa vol. 10 
07-06-2023
1035 Understanding dynamic immune responses within a 3D microfluidic model of human skin
Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J
Journal of Investigative Dermatology, Elsevier vol. 143 (5) 
01-05-2023
1157 Ozone as an aggravating factor in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E
Journal of Investigative Dermatology, Elsevier Bv vol. 143 (5), S198-S198.  
01-05-2023
753 Repairing the epidermal skin barrier in an in vivo model of junctional epidermolysis bullosa
Jones E, Marsh S, Aumailley M, McGrath JA, O'Toole E, Rognoni E, Caley M
Journal of Investigative Dermatology, Elsevier Bv vol. 143 (5), S129-S129.  
01-05-2023
741 The effect of skin ageing-related basement membrane collagen loss on the nucleus
Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M, O'Toole E
Journal of Investigative Dermatology, Elsevier vol. 143 (5), s127-s127.  
01-05-2023
763 Novel roles of laminin α3 in epidermal homeostasis
Parzymies PJ, Jones E, Mayes A, Messenger D, O'Toole E, Caley M
Journal of Investigative Dermatology, Elsevier Bv vol. 143 (5), S131-S131.  
01-05-2023
ISID1157 - Ozone as an aggravating factor in atopic eczema
Tawfik S, O'Toole E, Thomas B, Caley M, Jones E, O'Shaughnessy R
 
29-04-2023
Regulation of human trophoblast gene expression by endogenous retroviruses
Frost JM, Amante SM, Okae H, Jones EM, Ashley B, Lewis RM, Cleal JK, Caley MP et al.
Nature Structural &Amp; Molecular Biology, Springer Science and Business Media Llc vol. 30 (4), 527-538.  
01-04-2023
Ichthyosis linked to sphingosine 1-phosphate lyase insufficiency is due to aberrant sphingolipid and calcium regulation

Journal of Lipid Research, Elsevier vol. 64 (4) 
02-03-2023
Ozone as an aggravating factor in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E
 
01-01-2023
Repairing the epidermal skin barrier in an in vivo model of junctional epidermolysis bullosa
Jones E, Marsh S, Aumailley M, McGrath JA, O'Toole E, Rognoni E, Caley M
 
01-01-2023
The effect of skin ageing-related basement membrane collagen loss on the nucleus
Summan SK, Mayes A, Gunn DA, Gautrot J, Caley M, O'Toole E
 
01-01-2023
Novel roles of laminin α3 in epidermal homeostasis
Parzymies PJ, Jones E, Mayes A, Messenger D, O'Toole E, Caley M
 
01-01-2023
Understanding dynamic immune responses within a 3D microfluidic model of human skin
Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J
 
01-01-2023
Treatment of human palmoplantar keratoderma skin equivalents with a TRPV3 antagonist, KM-001
Caley M, Idrissi M, Braiman L, Brener E, O'Toole E
 
01-01-2023

2022

216 Understanding the Mechanisms of Epidermal Barrier Damage and Repair Using 3D Skin Equivalent Models
Dina DO, Caley MP, Raj N, O’Toole EA, Connelly J
Journal of Investigative Dermatology, Elsevier Bv vol. 142 (12), S217-S217.  
01-12-2022
191 Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O’Shaughnessy R, Aumailley M, McGrath JA, O’Toole EA, Caley MP
Journal of Investigative Dermatology, Elsevier Bv vol. 142 (12), S213-S213.  
01-12-2022
144 Carbonylated proteins and Ozone in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley MP, O’Shaughnessy R, O’Toole EA
Journal of Investigative Dermatology, Elsevier Bv vol. 142 (12), S204-S204.  
01-12-2022
181 Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions

Journal of Investigative Dermatology, Elsevier vol. 142 (12) 
01-12-2022
184 The role of the Laminin 332 in cholesterol transport in dry and Aged skin
Parzymies P, Jones E, Caley MP, O’Toole EA, Messenger D, Mayes A
Journal of Investigative Dermatology, Elsevier Bv vol. 142 (12), S212-S212.  
01-12-2022
Investigating wound healing characteristics of gingival and skin keratinocytes in organotypic cultures
Smith CJ, Parkinson EK, Yang J, Pratten J, O'Toole EA, Caley MP, Braun KM
Journal of Dentistry, Elsevier Bv vol. 125, 104251-104251.  
01-10-2022
ESDR144 - Carbonylated proteins and Ozone in atopic eczema
Tawfik S, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E, Thomas B, Prasad Baruah K
 
26-09-2022
ESDR216 - Understanding the Mechanisms of Epidermal Barrier Damage and Repair Using 3D Skin Equivalent Models
Dina D, Caley M, Raj N, O'Toole E, Connelly J
 
25-09-2022
ESDR184 - The role of the Laminin 332 in cholesterol transport in dry and Aged skin
Parzymies P, Jones E, Caley M, O'Toole E, Messenger D, Mayes A
 
23-09-2022
ESDR181 - Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions.

, Morressier 
22-09-2022
ESDR191 - Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O'Toole E, Caley M
 
22-09-2022
Regulation of human trophoblast gene expression by endogenous retroviruses
Branco M, Frost J, Amante S, Okae H, Jones E, Ashley B, Lewis R, Cleal J et al.
In Springer Science and Business Media Llc 
03-06-2022
Regulation of human trophoblast gene expression by endogenous retroviruses
Frost JM, Amante SM, Okae H, Jones EM, Ashley B, Lewis RM, Cleal JK, Caley MP et al.
In Cold Spring Harbor Laboratory 
26-04-2022
The role of the laminin 332-actin-cholesterol axis in skin conditions with altered lipid profiles
Parzymies P, Jones E, Caley M, O'Toole E, Mayes A, Messenger D
 
01-01-2022
Investigating the role of the basement membrane in modulating the inflammasome in ageing skin
Jones E, O'Toole E, Caley M
 
01-01-2022
Finding a new treatment for X-linked recessive ichthyosis
Huang M, Miettinen S, Caley M, O'Toole E
 
01-01-2022
Investigating the role of the basement membrane in modulating the skin inflammasome
Jones E, Stewart-McGuiness C, O'Toole E, Caley M
 
01-01-2022
Sphingosine 1-phosphate lyase insufficiency induced ichthyosis is due to sphingolipid imbalance, increased differentiation, and aberrant intercellular junctions
Smith CJ, Williams JL, Hall C, Caley MP, O'Toole EA, Prasad R, Metherell LA
 
01-01-2022
Carbonylated proteins and Ozone in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley MP, O'Shaughnessy R, O'Toole EA
 
01-01-2022
Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath JA, O'Toole EA, Caley MP
 
01-01-2022
The role of the Laminin 332 in cholesterol transport in dry and Aged skin
Parzymies P, Jones E, Caley MP, O'Toole EA, Messenger D, Mayes A
 
01-01-2022
Understanding the Mechanisms of Epidermal Barrier Damage and Repair Using 3D Skin Equivalent Models
Dina DO, Caley MP, Raj N, O'Toole EA, Connelly J
 
01-01-2022

2021

099 Ichthyosis associated with sphingosine 1-phosphate lyase deficiency is due to aberrant calcium and sphingolipid regulation
Smith CJ, Williams JL, Caley MP, O’Toole EA, Prasad R, Metherell LA
Journal of Investigative Dermatology vol. 141 (10), s165-s165.  
07-10-2021
Ichthyosis associated with sphingosine 1-phosphate lyase deficiency is due to aberrant calcium and sphingolipid regulation
Smith CJ, Williams JL, Caley MP, O'Toole EA, Prasad R, Metherell LA
 
01-01-2021

2020

Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing
Langton AK, Ayer J, Griffiths TW, Rashdan E, Naidoo K, Caley MP, Birch‐Machin MA, O'Toole EA et al.
Journal of The European Academy of Dermatology and Venereology, Wiley vol. 35 (3), 762-768.  
30-12-2020
Loss of the laminin subunit alpha‐3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma*
Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri V, Alexander S, Jones E et al.
British Journal of Dermatology, Oxford University Press (Oup) vol. 184 (5), 923-934.  
01-12-2020
3D model of harlequin ichthyosis reveals inflammatory therapeutic targets.
Enjalbert F, Dewan P, Caley MP, Jones EM, Morse MA, Kelsell DP, Enright AJ, O'Toole EA
Journal of Clinical Investigation, American Society For Clinical Investigation 
16-06-2020

2019

Junctional Epidermolysis Bullosa: Bottom Up Control Of The Skin Barrier?
Caley M, Mai Jones E
 
12-09-2019
274 Junctional Epidermolysis Bullosa: Bottom Up Control Of The Skin Barrier?
Jones EM, Marsh S, O’Shaughnessy RF, CAMERA E, Picardo M, Aumailley M, O’Toole E, Caley M
 
01-09-2019
298 Defective DNA Repair and Chromosomal Instability in RDEB
Caley M, Marsh S, Martins VL, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al.
 
01-09-2019
A Unique Panel of Patient-Derived Cutaneous Squamous Cell Carcinoma Cell Lines Provides a Preclinical Pathway for Therapeutic Testing
Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A et al.
International Journal of Molecular Sciences, Mdpi Ag vol. 20 (14), 3428-3428.  
12-07-2019
Type VII collagen and Nesprin 2: LINCing the basement membrane to altered cell cycle and increased DNA damage
Marsh S, Caley MP, Martins VLC, Corbett-Jones T, Chen M, Di W, Sheer D, McGrath JA et al.
 
01-01-2019
Differential ageing responses to chronic ultraviolet irradiation: characterizing the molecular phenotype of atrophic and hypertrophic facial skin
Langton AK, Ayer J, Griffiths TW, Rashdan E, Naidoo K, Caley MP, Birch-Machin MA, O'Toole E et al.
 
01-01-2019
Laminin 332: bottom-up control of the skin barrier?
Jones EM, Marsh ST, O'Shaughnessy RF, Aumailley M, Camera E, Picardo M, McGrath JA, O'Toole EA et al.
 
01-01-2019
Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis
Enjalbert F, Dewan P, Caley M, Morse M, Kelsell D, O'Toole E
 
01-01-2019
Novel frameshift variant in EBP: late diagnosis of Conradi-Hunermann syndrome in a 41-year-old woman
Thomas BR, Caley MP, O'Toole EA
 
01-01-2019

2018

680 A role for the basement membrane in skin lipid trafficking
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, O'Toole EA, Caley MP
 
01-05-2018
661 Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis
Enjalbert F, Dewan P, Caley MP, Fell B, Morse M, Kelsell D, Enright A, O'Toole EA
 
01-05-2018
812 Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage
Marsh S, Caley MP, Martins V, Chen M, McGrath J, Barnes M, O'Toole EA
 
01-05-2018
Development and Characterisation of a Human Chronic Skin Wound Cell Line—Towards an Alternative for Animal Experimentation
Caley M, Wall I, Peake M, Kipling D, Giles P, Thomas D, Stephens P
International Journal of Molecular Sciences, Mdpi Ag vol. 19 (4), 1001-1001.  
27-03-2018
Understanding Angiogenesis in Squamous Cell Carcinoma with Loss of Type VII Collagen
Alexander SC, Marsh S, Caley M, O'Toole EA
 
01-01-2018
Loss of Lamα3 drives M2 macrophage differentiation in squamous cell carcinoma
Caley M, Martins V, Moore K, Lashari M, Marshall J, O'Toole E
 
01-01-2018
The role of laminin 332 in skin lipid biosynthesis
Jones E, Marsh S, O'Shaugnessy R, Aumailley M, O'Toole E, Caley M
 
01-01-2018
Investigating the role of ABCA12 in the pathomechanisms of harlequin ichthyosis
Enjalbert F, Dewan P, Caley M, Fell B, Morse M, Kelsell D, Enright A, O'Toole E
 
01-01-2018
Phospholipase C-β4 regulation of chromatin via kindlin-2 in cutaneous squamous cell carcinoma
Huang M, Ruban E, Caley M, O'Toole E
 
01-01-2018
Development of a three-dimensional living skin equivalent to explore the influence of senescence on the skin ageing phenotype
Milligan D, Newman J, Caley M, Wainwright L, Jenkins G, Philpott M, Bishop C
 
01-01-2018
Investigating the differences in the wound healing responses of skin and gingival keratinocytes
Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J, Braun KM
 
01-01-2018
Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage
Marsh S, Caley MP, Martins V, Chen M, McGrath J, Barnes M, O'Toole EA
 
01-01-2018
A role for the basement membrane in skin lipid trafficking
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, O'Toole EA, Caley MP
 
01-01-2018
Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis
Enjalbert F, Dewan P, Caley MP, Fell B, Morse M, Kelsell D, Enright A, O'Toole EA
 
01-01-2018
INVESTIGATING THE DIFFERENCES IN THE WOUND HEALING RESPONSES OF SKIN AND GINGIVAL KERATINOCYTES
Smith CJ, Caley M, Parkinson EK, O'Toole EA, Pratten J, Yang J
 
01-01-2018

2017

192 Loss of keratinocyte type VII collagen induces increased DNA damage in vitro and in vivo
Marsh S, Caley M, Martins V, Barnes MR, Chen M, O’Toole EA
 
01-10-2017
Understanding the role of ABCA12 in the Pathogenesis of Harlequin Ichthyosis
Enjalbert F, Dewan P, Caley M, Fell B, Morse M, Kelsell DP, Enright A, O'Toole EA
ESDR 2017. 
01-10-2017
568 Investigation of the role of type VII collagen in the HIF1α induced pro-angiogenic pathway
Shams F, Krupiczojc MA, Alexander S, Rashidghamat E, McGrath J, Caley M, O’Toole EA, Harwood CA
 
01-10-2017
336 Tumour associated macrophage recruitment in SCC
Caley M, Martins V, Moore K, Lashari M, Marshall J, O’Toole EA
 
01-10-2017
682 Development of a 3D living skin equivalent to explore the influence of senescence on the skin ageing phenotype
Milligan D, Newman J, Caley M, Wainwright L, Jenkins G, Philpott M, Bishop C
 
01-10-2017

2016

472 Loss of Laminin α3 drives SCC invasion via ROCK signalling
Caley M, Martins V, Moore K, Lashari M, Kähäri V, Nissinen L, Donaldson M, Marshall J et al.
 
01-09-2016
132 Identification of novel pathways linked to the pathogenesis of Recessive X-Linked Ichthyosis
McGeoghan F, Menon M, Dewan P, Caley M, Donaldson M, O’Toole EA
 
01-09-2016
133 Understanding the role of ABCA12 in the pathogenesis of Harlequin Ichthyosis
Enjalbert F, Dewan P, Caley M, Fell B, Donaldson M, Kelsell DP, O’Toole EA
 
01-09-2016
569 Loss of collagen 7 drives HIF-1 alpha induced pro-angiogenic pathways
Krupiczojc MA, Caley M, Marsh S, Donaldson M, Martins V, O’Toole E
 
01-09-2016
375 Modelling and understanding pathomechanisms of X-linked recessive ichthyosis in vitro
McGeoghan FT, O’Toole E, Caley M, Menon M, Dewan P, Donaldson M
 
01-05-2016
Maternal DNA Methylation Regulates Early Trophoblast Development
Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ et al.
Developmental Cell, Elsevier Bv vol. 36 (2), 152-163.  
01-01-2016
ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332
Caley M, Martins V, Moore K, Lashari M, Donaldson M, Marshall JF, O'Toole EA
 
01-01-2016
Phospholipase C beta4 is a therapeutic target in cutaneous squamous cell carcinoma
O'Toole EA, Ruban EL, Balogun M, Martins VL, Caley MP, Falasca M
 
01-01-2016

2015

Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces
Caley MP, King H, Shah N, Wang K, Rodriguez-Teja M, Gronau JH, Waxman J, Sturge J
Clinical &Amp; Experimental Metastasis, Springer Science and Business Media Llc vol. 33 (2), 151-165.  
13-11-2015
A Novel Fully Humanized 3D Skin Equivalent to Model Early Melanoma Invasion
Hill DS, Robinson NDP, Caley MP, Chen M, O'Toole EA, Armstrong JL, Przyborski S, Lovat PE
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 14 (11), 2665-2673.  
01-11-2015
Cytoskeletal protein flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression
Kopecki Z, Yang GN, Jackson JE, Melville EL, Caley MP, Murrell DF, Darby IA, O’Toole EA et al.
Oncotarget, Impact Journals, Llc vol. 6 (34), 36426-36440.  
19-10-2015
Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC.
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al.
J Natl Cancer Inst vol. 108 (1) 
16-10-2015
Pharmacological inhibition of Axl tyrosine kinase as a novel therapeutic strategy in hepatocellular carcinoma.
Pinato DJ, Trousil S, Caley M, Mauri FA, Aboagye E, Sharma R
 
20-05-2015
Metalloproteinases and Wound Healing
Caley MP, Martins VLC, O'Toole EA
Advances in Wound Care, Mary Ann Liebert Inc vol. 4 (4), 225-234.  
01-04-2015
Generation of an in vitro three-dimensional model of X-linked recessive ichthyosis
McGeoghan F, Dewan P, Caley M, Donaldson M, O'Toole E
 
01-01-2015
Squamous Cell Carcinoma progression and Laminin 332
Caley M, Martins V, Marsh S, Moore K, Lashari M, Donaldson MJ, Marshall J, O'toole E
 
01-01-2015
Modelling X-linked recessive ichthyosis in vitro
McGeoghan FT, Derwin P, Caley M, Donaldson MJ, O'toole E
 
01-01-2015
Loss of keratinocyte type VII collagen induces pro-carcinogenic transcriptomic pathways
Marsh S, Martins V, Caley M, Barnes M, Donaldson MJ, O'toole E
 
01-01-2015
Skin type VII collagen acts as a tumour suppressor by regulating TGFβ and angiogenesis
Martins V, Caley M, Moore K, Szentpetery Z, Marsh S, Murrell DF, Kaehaeri V, McGrath J et al.
 
01-01-2015

2014

AGE\n ‐modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival
Rodriguez‐Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR et al.
The Journal of Pathology, Wiley vol. 235 (4), 581-592.  
24-12-2014
Identification of a transcriptional signature for the wound healing continuum
Peake MA, Caley M, Giles PJ, Wall I, Enoch S, Davies LC, Kipling D, Thomas DW et al.
Wound Repair and Regeneration, Wiley vol. 22 (3), 399-405.  
01-05-2014
Diverse roles for laminin-332 subunits in squamous cell carcinoma
Caley M, Martins V, Moore K, Marshall J, O'Toole E
 
01-01-2014
Global transcriptomic changes in primary keratinocytes with loss of basement membrane genes
Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'Toole E
 
01-01-2014
Phospholipase C beta4 regulates invasion and proliferation in cutaneous SCC in vivo
Ruban EL, Balogun MA, Martins V, Caley M, Raimondi C, O'toole E, Falasca M
 
01-01-2014
Diverse roles for laminin 332 subunits in squamous cell carcinoma
Caley M, Martins V, Moore K, Marshall J, O'toole E
 
01-01-2014
RNA-Seqing the skin basement membrane
Marsh S, Martins V, Caley M, Barnes M, Donaldson M, O'toole E
 
01-01-2014
Cytoskeletal protein Flii is elevated in human cSCCs and overexpression of Flii in mice leads to higher incidence and severity of tumour formation
Kopecki Z, Yang G, Jackson J, Melville E, Martin V, Caley M, Proby C, Pouniotis D et al.
 
01-01-2014

2013

The receptor tyrosine kinase Axl regulates cell–cell adhesion and stemness in cutaneous squamous cell carcinoma
Cichoń MA, Szentpetery Z, Caley MP, Papadakis ES, Mackenzie IC, Brennan CH, O'Toole EA
Oncogene, Springer Science and Business Media Llc vol. 33 (32), 4185-4192.  
23-09-2013
miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts
Pellegrino L, Stebbing J, Braga VM, Frampton AE, Jacob J, Buluwela L, Jiao LR, Periyasamy M et al.
Nucleic Acids Research, Oxford University Press (Oup) vol. 41 (10), 5400-5412.  
10-04-2013
Phospholipase C-beta 4 regulates proliferation and invasion in cutaneous SCC
Ruban EL, Martins VL, Caley M, Raimondi C, Falasca M, O'Toole EA
 
01-01-2013
Diverse roles for laminin 332 subunits in squamous cell carcinoma
Caley MP, Martins V, Moore K, Marshall JF, O'Toole EA
 
01-01-2013
Transcriptome profiling identifies novel functions of acitretin in human epidermis
Marsh ST, Caley MP, Kwan A, O'Toole EA, Donaldson M
 
01-01-2013
Loss of type VII collagen in cutaneous SCC increases angiogenesis
Martins VL, Caley MP, Moore K, Szentpetery Z, Murrell DF, Kim MH, McGrath JA, Cerio R et al.
 
01-01-2013
Alternatives for animal wound model systems

Methods in Molecular Biology vol. 1037, 177-201.  
01-01-2013
Formation and inhibition of invadopodia in oral squamous cell carcinoma
Ali I, Gautrot J, Caley M, Marshall JF, Wheeler A
 
01-01-2013
Alternatives for Animal Wound Model Systems
Stephens P, Caley M, Peake M
, Humana Press, 177-201.  
01-01-2013

2012

Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer
Palmieri C, Caley MP, Purshouse K, Fonseca A-V, Rodriguez-Teja M, Kogianni G, Woodley L, Odendaal J et al.
British Journal of Cancer, Springer Science and Business Media Llc vol. 108 (1), 163-169.  
20-12-2012
Abstract P2-02-03: The Collagen Receptor Endo180: A Metastatic Plasma Marker In Breast Cancer Modulated By Bisphosphonate Treatment
Sturge J, Caley MP, Purshouse K, Fonseca A-V, Rodriguez-Teja M, Kogianni G, Waxman J, Palmieri C
 
15-12-2012
Matrix metalloproteinases and epidermal wound repair
Martins VL, Caley M, O’Toole EA
Cell and Tissue Research, Springer Science and Business Media Llc vol. 351 (2), 255-268.  
18-04-2012
Fluorescence‐based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells
Ramasamy K, Khatun H, Macpherson L, Caley MP, Sturge J, Mufti GJ, Schey SA, Calle Y
British Journal of Haematology, Wiley vol. 157 (5), 564-579.  
20-03-2012
Loss of type VII collagen in squamous cell carcinoma increases angiogenesis in vitro and in vivo
Martins V, Caley M, Moore K, Chen M, Marshall J, O'Toole E
 
01-01-2012
Loss of keratinocyte type VII collagen in SCC increases TGF-beta signalling and angiogenesis
Martins V, Caley M, Moore K, Murrell DF, McGrath JA, Chen M, Marshall JF, O'Toole EA
 
01-01-2012
Keratin 15 and VZV replication in skin
Singh M, Caley M, Jones M, Breuer J, O'Toole E
 
01-01-2012
The receptor tyrosine kinase Axl regulates intercellular adhesion, epithelial-mesenchymal transition and stemness in cutaneous squamous cell carcinoma
Szentpetery Z, Cichon M, Caley M, O'Toole E
 
01-01-2012

2011

TGFβ1–Endo180‐dependent collagen deposition is dysregulated at the tumour–stromal interface in bone metastasis
Caley MP, Kogianni G, Adamarek A, Gronau JH, Rodriguez‐Teja M, Fonseca A, Mauri F, Sandison A et al.
The Journal of Pathology, Wiley vol. 226 (5), 775-783.  
08-12-2011
Correction: Bone metastasis in prostate cancer: emerging therapeutic strategies
Sturge J, Caley MP, Waxman J
Nature Reviews Clinical Oncology, Springer Nature vol. 8 (10), 568-568.  
30-09-2011
Authors' reply: Expanding horizons in metastatic prostate cancer treatment
Sturge J, Caley MP, Waxman J
Nature Reviews Clinical Oncology, Springer Science and Business Media Llc vol. 8 (10), 625-625.  
30-08-2011
Bone metastasis in prostate cancer: emerging therapeutic strategies
Sturge J, Caley MP, Waxman J
Nature Reviews Clinical Oncology, Springer Science and Business Media Llc vol. 8 (6), 357-368.  
10-05-2011

2010

Sphingosine kinase-1 and the collagen-binding receptor Endo180 cooperate to mediate collagen remodelling by stromal fibroblasts
Bruche S, Caley MP, Pshezhetskiy D, Sturge J
 
01-01-2010

2008

Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals
Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V, Upadhyaya M
Genes Chromosomes & Cancer vol. 47 (3), 238-246.  
01-01-2008

2007

Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals
Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V, Upadhyaya M
Genes, Chromosomes and Cancer, Wiley vol. 47 (3), 238-246.  
10-12-2007
Development and characterisation of a human cell-based chronic wound bioassay
Caley M, Wall I, Kipling D, Thomas DW, Stephens P
Wound Repair and Regeneration vol. 15 (6), A133-A133.  
01-01-2007

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconImproving the regenerative capacity of Junctional Epidermolysis Bullosa skin by re-activating YAP/TAZ signalling.
Gernot Walko, Matthew Caley and Emanuel Rognoni
£139,962 DEBRA UK
01-04-2025 - 31-03-2029
bullet iconTreat EB CRO
Matthew Caley and Emanuel Rognoni
£840,000 DEBRA Research GmbH
01-04-2025 - 31-03-2028
bullet iconEvaluation of long-term effect on skin homeostasis and regeneration in a RDEB mouse model using different delivery methods of LNPs encapsulating mRNA-based base editing approach
Emanuel Rognoni and Matthew Caley
£38,000 Cure EB
01-01-2025 - 31-12-2027
bullet iconCell Adhesion and signalling testing (Scion)
Matthew Caley and Emanuel Rognoni
£71,941 Scion Innovations LLC
01-10-2024 - 31-12-2025
bullet iconEpidermal differentiation barrier and metabolism The role of basement membrane proteins in skin homeostasis ostasis.
Matthew Caley and Edel O'Toole
£127,935 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2024 - 30-09-2028
bullet iconSkin differentiation, barrier and metabolism: The role of the basement membrane in skin homeostasis.
Matthew Caley and Edel O'Toole
£75,600 Unilever UK Ltd
01-10-2024 - 30-09-2028
bullet iconIndustrial CASE: Genotypic phenotypic and metabolic characterisation of skin sentinels
Matthew Caley
£125,091 BBSRC Biotechnology and Biological Sciences Research Council
30-09-2024 - 29-09-2028
bullet iconWound Healing Screening
Matthew Caley
£124,270 WHRL William Harvey Research Limited
01-06-2024 - 31-12-2025
bullet iconEstablishing a murine RDEB disease model at QMUL
Emanuel Rognoni and Matthew Caley
£39,736 Barts and the London Charity
01-05-2024 - 01-11-2025
bullet iconImproving skin regeneration in JEB by targeting the integrin αvβ6
Emanuel Rognoni, John Marshall and Matthew Caley
£139,962 DEBRA UK
01-05-2024 - 30-04-2028
bullet iconDissecting The Role Of Inflammatory pathways In Epidermolysis Bullosa (EB) Pathology
Emma Chambers, Emanuel Rognoni and Matthew Caley
£139,912 DEBRA UK
01-04-2024 - 31-03-2028
bullet iconTesting the in vivo efficacy of base and prime editing in primary fibroblasts and in a 3D skin model of dystrophic epidermolysis bullosa
Emanuel Rognoni and Matthew Caley
£30,000 Cure EB
01-01-2024 - 30-09-2027
bullet iconTreating JEB with Recombinant Laminin 332
Matthew Caley and Emanuel Rognoni
£177,304 DEBRA International
01-01-2024 - 31-12-2025
solid heart iconGenotypic, Phenotypic and Metabolic Characterisation of Skin Sentinels
Matthew Caley and Simon McArthur
£75,600 Unilever UK Ltd
01-10-2023 - 30-09-2027
bullet iconDissecting EB Heterogeneity
Matthew Caley, Emanuel Rognoni and Edel O'Toole
£182,396 Barts and the London Charity
03-04-2023 - 02-04-2027
bullet iconExploring the role and therapeutic potential of dermal fibroblasts in Junctional epidermolysis bullosa
Emanuel Rognoni and Matthew Caley
£227,055 Great Ormond Street Hospital Children's Charity
01-09-2022 - 31-12-2025
bullet iconThe role of inflammasome in ageing skin
Eleri Jones and Matthew Caley
£89,978 British Skin Foundation (BSF)
01-09-2022 - 31-03-2026
bullet iconConsortium on the skin microbiome
Matthew Caley
£16,061 Biotechnology and Biological Sciences Research Council
14-02-2022 - 30-09-2025
bullet iconHow does ageing related loss of basement membrane collagen regulate epidermal barrier homeostasis
Edel O'Toole, Julien Gautrot and Matthew Caley
£64,000 Unilever UK Ltd
01-10-2021 - 30-11-2025
bullet iconHow does ageing related loss of basement membrane collagen regulate epidermal barrier homeostasis
Edel O'Toole, Julien Gautrot and Matthew Caley
£116,803 BBSRC Biotechnology and Biological Sciences Research Council
27-09-2021 - 20-12-2025

bullet iconDiabetic wound compound testing
Emanuel Rognoni and Matthew Caley
£16,090 PARTERRA LIMITED
16-07-2025 - 06-08-2025
bullet iconUsing JAK inhibitors to repair the skin barrier in severe ichthyosis
Edel O'Toole, Emanuel Rognoni and Matthew Caley
£192,684 LifeArc
01-11-2021 - 31-08-2024
bullet iconUnderstanding the healing potential of the oral mucosa
Emanuel Rognoni, Matthew Caley and Farida Fortune Cbe
£256,896 MCSBHT Medical College of St Bartholomew's Hospital Trust
01-09-2021 - 31-03-2025
bullet iconThe role of the Laminin 332-Actin-Cholesterol axis in skin conditions with altered lipid profiles
Matthew Caley and Edel O'Toole
£64,000 Unilever UK Ltd
01-10-2020 - 30-06-2025
bullet iconThe Role Of The Laminin 332-Actin-Cholesterol Axis In Skin Conditions With Altered Lipid Profiles - BBSRC Unilever ICASE
Matthew Caley
£114,126 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2020 - 30-09-2024
bullet iconRepairing the skin barrier in Juctional Epidermolysis Bullosa (JEB)
Matthew Caley and Edel O'Toole
£152,122 LifeArc
01-09-2020 - 30-11-2022
bullet iconRestoring Aged Skin; From the Bottom Up
Edel O'Toole and Matthew Caley
£85,234 Medtech SuperConnector
22-10-2019 - 31-12-2020
bullet iconThe basement membrane and lipid biosystems in normal and diseased skin
Matthew Caley
£89,999 British Skin Foundation (BSF)
06-06-2017 - 31-07-2019