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Dr Matthew Caley

Matthew Caley

Lecturer in Cell Biology

Blizard Institute,
Queen Mary University of London
07971 890473

Research

Skin, Lipids, rare diseases, screening, Extracellular Matrix, Laminin 332

Interests

My research focusses on the skin basement membrane and specifically laminin 332 a three-chained glycoprotein which is copiously secreted by epithelial cells. We have demonstrated an important role for laminin 332 in skin ageing, squamous cell carcinoma invasion, cholesterol transport and in skin immune regulation. To study these diverse functions we have generated co-culture and 3D skin models including models of aged skin that have allowed us to test gene knockdowns and drug treatments. We have also developed and validated a high throughput screen to identify compounds altering cholesterol transport within the skin.

Publications

Publications of specific relevance to Predictive in vitro Models

2021

(2021). Loss of the laminin subunit alpha-3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma. Br J Dermatol  vol. 184, (5) 923-934. 10.1111/bjd.19471
(2021). Distinctive clinical and histological characteristics of atrophic and hypertrophic facial photoageing. Journal of The European Academy of Dermatology and Venereology  vol. 35, (3) 762-768. 10.1111/jdv.17063

2020

(2020). 3D model of harlequin ichthyosis reveals inflammatory therapeutic targets. American Society For Clinical Investigation  Journal of Clinical Investigation  10.1172/JCI132987

2019

Hassan S, Purdie KJ, Wang J, Harwood CA, Proby CM, Pourreyron C, Mladkova N, Nagano A, Dhayade S, Athineos D, Caley M, Mannella V, Blyth K, Inman GJ and Leigh IM (2019). A unique panel of patient-derived cutaneous squamous cell carcinoma cell lines provides a preclinical pathway for therapeutic testing. International Journal of Molecular Sciences  vol. 20, (14) 10.3390/ijms20143428

2018

(2018). 680 A role for the basement membrane in skin lipid trafficking. Journal of Investigative Dermatology  vol. 138, (5) 10.1016/j.jid.2018.03.689
(2018). 661 Understanding the role of ABCA12 in the pathogenesis of harlequin ichthyosis. Journal of Investigative Dermatology  vol. 138, (5) 10.1016/j.jid.2018.03.670
(2018). 812 Type VII collagen and Nesprin 2, LINCing the basement membrane to altered cell cycle and increased DNA damage. Journal of Investigative Dermatology  vol. 138, (5) 10.1016/j.jid.2018.03.822
Caley M, Wall IB, Peake M, Kipling D, Giles P, Thomas DW and Stephens P (2018). Development and characterisation of a human chronic skin wound cell line—towards an alternative for animal experimentation. International Journal of Molecular Sciences  vol. 19, (4) 10.3390/ijms19041001

2016

Caley MP, King H, Shah N, Wang K, Rodriguez-Teja M, Gronau JH, Waxman J and Sturge J (2016). Tumor-associated Endo180 requires stromal-derived LOX to promote metastatic prostate cancer cell migration on human ECM surfaces. Clinical and Experimental Metastasis  vol. 33, (2) 151-165. 10.1007/s10585-015-9765-7
Branco MR, King M, Perez-Garcia V, Bogutz AB, Caley M, Fineberg E, Lefebvre L, Cook SJ, Dean W, Hemberger M and Reik W (2016). Maternal DNA Methylation Regulates Early Trophoblast Development. Developmental Cell  vol. 36, (2) 152-163. 10.1016/j.devcel.2015.12.027

2015

(2015). A novel fully humanized 3D skin equivalent to model early melanoma invasion. Molecular Cancer Therapeutics  vol. 14, (11) 2665-2673. 10.1158/1535-7163.MCT-15-0394
(2015). Cytoskeletal protein Flightless I inhibits apoptosis, enhances tumor cell invasion and promotes cutaneous squamous cell carcinoma progression. Impact Journals  Oncotarget  vol. 6, (34) 36426-36440. 10.18632/oncotarget.5536
(2015). Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC. J Natl Cancer Inst  vol. 108, (1) 10.1093/jnci/djv293
(2015). Metalloproteinases and Wound Healing. Adv Wound Care (New Rochelle)  vol. 4, (4) 225-234. 10.1089/wound.2014.0581
Rodriguez-Teja M, Gronau JH, Breit C, Zhang YZ, Minamidate A, Caley MP, McCarthy A, Cox TR, Erler JT, Gaughan L, Darby S, Robson C, Mauri F, Waxman J and Sturge J (2015). AGE-modified basement membrane cooperates with Endo180 to promote epithelial cell invasiveness and decrease prostate cancer survival. Journal of Pathology  vol. 235, (4) 581-592. 10.1002/path.4485

2014

(2014). The receptor tyrosine kinase Axl regulates cell-cell adhesion and stemness in cutaneous squamous cell carcinoma. Oncogene  vol. 33, (32) 4185-4192. 10.1038/onc.2013.388
Peake MA, Caley M, Giles PJ, Wall I, Enoch S, Davies LC, Kipling D, Thomas DW and Stephens P (2014). Identification of a transcriptional signature for the wound healing continuum. Wound Repair Regen  vol. 22, (3) 399-405. 10.1111/wrr.12170

2013

Pellegrino L, Stebbing J, Braga VM, Frampton AE, Jacob J, Buluwela L, Jiao LR, Periyasamy M, Madsen CD, Caley MP, Ottaviani S, Roca-Alonso L, El-Bahrawy M, Coombes RC, Krell J and Castellano L (2013). miR-23b regulates cytoskeletal remodeling, motility and metastasis by directly targeting multiple transcripts. Nucleic Acids Res  vol. 41, (10) 5400-5412. 10.1093/nar/gkt245
(2013). Matrix metalloproteinases and epidermal wound repair. Cell Tissue Res  vol. 351, (2) 255-268. 10.1007/s00441-012-1410-z
Palmieri C, Caley MP, Purshouse K, Fonseca A-V, Rodriguez-Teja M, Kogianni G, Woodley L, Odendaal J, Elliott K, Waxman J and Sturge J (2013). Endo180 modulation by bisphosphonates and diagnostic accuracy in metastatic breast cancer. Br J Cancer  vol. 108, (1) 163-169. 10.1038/bjc.2012.540
Stephens P, Caley M and Peake M (2013). Alternatives for animal wound model systems. Methods Mol Biol  vol. 1037, 177-201. 10.1007/978-1-62703-505-7_10
Stephens P, Caley M and Peake M (2013). Alternatives for animal wound model systems. Methods in Molecular Biology  vol. 1037, 177-201. 10.1007/978-1-62703-505-7_10

2012

Ramasamy K, Khatun H, Macpherson L, Caley MP, Sturge J, Mufti GJ, Schey SA and Calle Y (2012). Fluorescence-based experimental model to evaluate the concomitant effect of drugs on the tumour microenvironment and cancer cells. Br J Haematol  vol. 157, (5) 564-579. 10.1111/j.1365-2141.2012.09103.x
Caley MP, Kogianni G, Adamarek A, Gronau JH, Rodriguez-Teja M, Fonseca A-V, Mauri F, Sandison A, Rhim JS, Pchejetski D, Palmieri C, Cobb JP, Waxman J and Sturge J (2012). TGFβ1-Endo180-dependent collagen deposition is dysregulated at the tumour-stromal interface in bone metastasis. J Pathol  vol. 226, (5) 775-783. 10.1002/path.3958

2011

Sturge J, Caley MP and Waxmanin J (2011). Authors' reply: Expanding horizons in metastatic prostate cancer treatment. Nature Reviews Clinical Oncology  vol. 8, (10) 10.1038/nrclinonc.2011.67-c2
Sturge J, Caley MP and Waxman J (2011). Bone metastasis in prostate cancer: emerging therapeutic strategies (vol 8, pg 357, 2011). Nature Reviews Clinical Oncology  vol. 8, (10) 568-568. 10.1038/nrclinonc.2011.127
Sturge J, Caley MP and Waxman J (2011). Bone metastasis in prostate cancer: emerging therapeutic strategies. Nat Rev Clin Oncol  vol. 8, (6) 357-368. 10.1038/nrclinonc.2011.67

2008

Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V and Upadhyaya M (2008). Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type 1 individuals. Genes Chromosomes Cancer  vol. 47, (3) 238-246. 10.1002/gcc.20525
Mantripragada KK, Caley M, Stephens P, Jones CJ, Kluwe L, Guha A, Mautner V and Upadhyaya M (2008). Telomerase activity is a biomarker for high grade malignant peripheral nerve sheath tumors in neurofibromatosis type I individuals. Genes Chromosomes & Cancer  vol. 47, (3) 238-246. 10.1002/gcc.20525

2007

Caley M, Wall I, Kipling D, Thomas DW and Stephens P (2007). Development and characterisation of a human cell-based chronic wound bioassay. Wound Repair and Regeneration  vol. 15, (6) A133-A133.