Prof Li Chan

Li Chan

Professor of Molecular Endocrinology and Metabolism/Paediatric Endocrinologist

Centre for Endocrinology
Queen Mary University of London


Obesity, HPA, Melanocortin receptors, Accessory proteins, Appetite, Stress

Neuronal Models


I am Professor of Molecular Endocrinology and Metabolism/Honorary Consultant Paediatric Endocrinology at QMUL and Barts Health. My research is in the area of adrenal and metabolic dysfunction and as such I work on in-vitro and in-vivo models for these.


Publications of specific relevance to Predictive in vitro Models


Chung T-TLL, Chan LF, Metherell LA and Clark AJL (2010). Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2. Clin Endocrinol (Oxf)  vol. 72, (5) 589-594. 10.1111/j.1365-2265.2009.03663.x
Dias RP, Kumaran A, Chan LF, Martin L, Afshar F, Matson M, Plowman PN, Monson JP, Besser GM, Grossman AB, Savage MO and Storr HL (2010). Diagnosis, management and therapeutic outcome in prepubertal Cushing's disease. Eur J Endocrinol  vol. 162, (3) 603-609. 10.1530/EJE-09-0509
Dias RP, Chan LF, Metherell LA, Pearce SHS and Clark AJL (2010). Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency. Eur J Endocrinol  vol. 162, (2) 357-359. 10.1530/EJE-09-0720


Chan LF, Metherell LA, Krude H, Ball C, O'Riordan SMP, Costigan C, Lynch SA, Savage MO, Cavarzere P and Clark AJL (2009). Homozygous nonsense and frameshift mutations of the ACTH receptor in children with familial glucocorticoid deficiency (FGD) are not associated with long-term mineralocorticoid deficiency. Clin Endocrinol (Oxf)  vol. 71, (2) 171-175. 10.1111/j.1365-2265.2008.03511.x
Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertov√° M, Elphick MR, Cheetham ME, Metherell LA and Clark AJL (2009). MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A  vol. 106, (15) 6146-6151. 10.1073/pnas.0809918106


Grants of specific relevance to Predictive in vitro Models
Cell DIVE Imager for automated, single cell, multiplexed immunofluorescence microscopy
Bishop CL, Bourke CD, Chan LF, Dalli J, Graham TA, Licenikova Horejsi Z, Martin-Duran JM, Nourshargh S, Prendergast A and Riches J
£340,339 Wellcome Trust (20-11-2021 - 19-11-2026)
Barts Metabolism Network - Regulating brown fat thermogenesis and white fat beigeing to treat obesity and its co-morbidities
Chan L
£498,545 Bart's Charity (01-04-2022 - 01-06-2025)

Molecular characterisation of MC2R/MRAP antagonists for the treatment of ACTH excess in pituitary and neuroendocrine tumours.
Chan LF and Popat D
Medical Research Council (24-09-2020 - 31-03-2024)
An interdisciplinary ageing alliance: cellular metabolism over a life-course in socioeconomic disadvantaged populations
Henson S, Chan LF, Courtin E and Vasilaki A
£202,431 Biotechnology and Biological Sciences Research Council (14-02-2022 - 13-02-2024)
Improved genetic diagnosis of primary adrenal insufficiency
Storr HL, Metherell LA and Chan L
£500,199 Barts Charity (01-08-2018 - 31-07-2022)
Adrenal dysfunction and obesity in Down Syndrome
Chan LF
£99,984 Wellcome Trust (20-01-2020 - 20-10-2021)
The role of MRAPs in the control of melanocortin receptor dependent energy homeostasis and adrenal function
Chan LF
£1,025,346 Medical Research Council (04-01-2010 - 07-08-2017)
MRAP2 (Melanocortin Receptor Accessory Protein Two) and its role in melanocortin receptor trafficking and expression
Chan LF
£130,934 Medical Research Council (04-09-2006 - 03-09-2008)