Dr Li Chan

Li Chan

Reader in Molecular Endocrinology and Metabolism

Centre for Endocrinology
Queen Mary University of London
ORCiD Twitter

Research

Obesity, HPA, Melanocortin receptors, Accessory proteins, Appetite, Stress

Neuronal Models

Interests

I am a Reader in Molecular Endocrinology and Metabolism/Honorary Consultant Paediatric Endocrinology at QMUL. My research is in the area of adrenal and metabolic dysfunction and as such I work on in-vitro and in-vivo models for these.

Publications

Publications of specific relevance to Predictive in vitro Models

2023

Parry CM, Chan LF, Carr DF and Hawcutt DB (2023). Platelet-derived growth factor D expression in adrenal cells is modulated by corticosteroids: putative role in adrenal suppression. Pediatr Res  vol. 93, (1) 97-101. 10.1038/s41390-022-02094-9

2022

Chan L, Smith C, Read J, Hall C, Maharaj A, Ramirez LM, Qamar Y, Hughes C, Clark A, Musa S, Prasad R and Metherell L (2022). RF33 | PSAT69 A Combined Candidate Gene/Whole Exome Sequencing Approach Permits a Rapid Genetic Diagnosis for >81% Individuals with Primary Adrenal Insufficiency. Journal of The Endocrine Society  vol. 6, (Suppl 1) a140-a141. 10.1210/jendso/bvac150.286
Chan L (2022). Identification of a novel specific small-molecule melanocortin-2-receptor antagonist. Bioscientifica  Endocrine Connections  vol. 11, (12) 10.1530/EC-22-0338
Aslam A, Baksh A, Pape S, Consortium G-D, Strydom A, Gulliford M and Chan L (2022). Diabetes and obesity in down syndrome across the lifespan: a retrospective cohort study using UK electronic health records. Endocrine Abstracts  10.1530/endoabs.85.oc9.3
Maitra S, Smith C, Hall C, Read J, Maharaj AV, Mariela MRL, Qamar Y, Prasad R, Chan LF and Metherell LA (2022). The lack of genotype: phenotype correlations in rare causes of primary adrenal insufficiency highlights the need for genetic testing. Endocrine Abstracts  10.1530/endoabs.85.oc5.5
Aslam A, Baksh A, Pape S, Strydom A, Gulliford M and Chan L (2022). Diabetes and obesity in Down Syndrome across the lifespan: a retrospective cohort study using UK electronic health records. American Diabetes Association  Diabetes Care  10.2337/dc22-0482
Baksh RA, Strydom A, Pape SE, Chan LF and Gulliford MC (2022). Susceptibility to COVID-19 Diagnosis in People with Down Syndrome Compared to the General Population: Matched-Cohort Study Using Primary Care Electronic Records in the UK. Journal of General Internal Medicine  vol. 37, (8) 2009-2015. 10.1007/s11606-022-07420-9
Smith C, Read J, Hall C, Maharaj A, Marroquin RL, Qamar Y, Hughes C, Clark A, Prasad R, Chan L, Musa S and Metherell L (2022). A rapid genetic diagnosis for >80% individuals with non-CAH Primary Adrenal Insufficiency is achievable by candidate gene sequencing combined with WES. Endocrine Abstracts  10.1530/endoabs.81.rc2.1
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH, Chan LF, Moyes AJ and Hobbs AJ (2022). C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis. Proc Natl Acad Sci U S A  vol. 119, (13) 10.1073/pnas.2116470119

2021

Smith C, Maharaj A, Qamar Y, Read J, Williams J, Marimuthu V, Chan L and Metherell L (2021). In vitro splicing assay proves the pathogenicity of intronic variants in MRAP. Endocrine Abstracts  10.1530/endoabs.77.p134
H I, O D, F F, V C, AK G, NJ R, J B, V P, Y P, LF C, D B-Z, PJ M, Y N and M S-B (2021). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signalling. 10.1530/ey.18.11.2
Degtjarik O, Israeli H, Chan LF, Ben-Zvi D, Niv MY, McCormick PJ and Shalev-Benami M (2021). To eat or not to eat: cryo-EM structure of melanocortin receptor 4 reveals mechanism of a 'hunger switch' initiating satiety signalling. Acta Crystallographica Section a: Foundations and Advances  vol. 77, (a2) c480-c480. 10.1107/s0108767321092060
Buonocore F, Maharaj A, Qamar Y, Koehler K, Suntharalingham JP, Chan LF, Ferraz-De-Souza B, Hughes CR, Lin L, Prasad R, Allgrove J, Andrews ET, Buchanan CR, Cheetham TD, Crowne EC, Davies JH, Gregory JW, Hindmarsh PC, Hulse T, Krone NP, Shah P, Shaikh MG, Roberts C, Clayton PE, Dattani MT, Thomas NS, Huebner A, Clark AJ, Metherell LA and Achermann JC (2021). Genetic Analysis of Pediatric Primary Adrenal Insufficiency of Unknown Etiology: 25 Years' Experience in the UK. Journal of The Endocrine Society  vol. 5, (8) 10.1210/jendso/bvab086
Chan LF and Ramachandrappa S (2021). Genetics of Adrenal Insufficiency. Oxford Textbook of Endocrinology and Diabetes 3e  10.1093/med/9780198870197.003.0102
Israeli H, Degtjarik O, Fierro F, Chunilal V, Gill AK, Roth NJ, Botta J, Prabahar V, Peleg Y, Chan LF, Ben-Zvi D, McCormick PJ, Niv MY and Shalev-Benami M (2021). Structure reveals the activation mechanism of the MC4 receptor to initiate satiation signaling. Science  vol. 372, (6544) 808-814. 10.1126/science.abf7958
Smith C, Maharaj AV, Qamar Y, Read J, Williams J, Chan L, Marimuthu V and Metherell L (2021). In Vitro Splicing Assay Proves the Pathogenicity of Intronic Variants in MRAP. Journal of The Endocrine Society  vol. 5, (Suppl 1) a85-a86. 10.1210/jendso/bvab048.172
Maudhoo A, Maharaj A, Buonocore F, Martos-Moreno GA, Argente J, Achermann JC, Chan LF and Metherell LA (2021). Missplicing due to a synonymous, t96= exonic substitution in the t-box transcription factor tbx19 resulting in isolated acth deficiency. Endocrinology, Diabetes and Metabolism Case Reports  vol. 2021, (1) 10.1530/EDM-21-0128

2020

Maharaj A, Williams J, Bradshaw T, Güran T, Braslavsky D, Casas J, Chan LF, Metherell LA and Prasad R (2020). Sphingosine-1-phosphate lyase (SGPL1) deficiency is associated with mitochondrial dysfunction. J Steroid Biochem Mol Biol  vol. 202, 10.1016/j.jsbmb.2020.105730

2019

Qamar Y, Maharaj A, Chan L, AbdulBagi S, Abdullah M and Metherell L (2019). Rare causes of primary adrenal insufficiency (PAI) in children from Sudan. Endocrine Abstracts  10.1530/endoabs.66.oc5.9
Smith C, Maharaj A, Prasad R, Hughes C, Qamar Y, Clark A, Chan L and Metherell L (2019). Twenty-five years of familial glucocorticoid deficiency: genotypic and phenotypic variability. Endocrine Abstracts  10.1530/endoabs.65.p48
Qamar Y, Maharaj A, Chan L, Deeb A and Metherell L (2019). Splice-site mutations in the melanocortin-2 receptor accessory protein that lead to early-onset familial glucocorticoid deficiency type 2. Endocrine Abstracts  10.1530/endoabs.65.cc2
Novoselova TV, King PJ, Guasti L, Metherell LA, Clark AJL and Chan LF (2019). ACTH signalling and adrenal development: Lessons from mouse models. Endocrine Connections  vol. 8, (7) R122-R130. 10.1530/EC-19-0190
Maharaj A, Maudhoo A, Chan LF, Novoselova T, Prasad R, Metherell LA and Guasti L (2019). Isolated glucocorticoid deficiency: Genetic causes and animal models. Journal of Steroid Biochemistry and Molecular Biology  vol. 189, 73-80. 10.1016/j.jsbmb.2019.02.012
Clark AJL and Chan L (2019). Stability and Turnover of the ACTH Receptor Complex. Front Endocrinol (Lausanne)  vol. 10, 10.3389/fendo.2019.00491

2018

Maudhoo A, Maharaj A, Buonocore F, Martos-Moreno GA, Argente J, Achermann J, Chan L and Metherell L (2018). Missplicing due to a silent exonic substitution in the T-box transcription factor TBX19 resulting in Isolated ACTH deficiency. Endocrine Abstracts  10.1530/endoabs.59.cc2
Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL and Chan LF (2018). MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. Faseb Journal  vol. 32, (11) 6186-6196. 10.1096/fj.201701274RR
Chan L, Hussain M, Forfar R, Khurana P, Cook J, Lewis S, McIver E, Jerman J, Taylor D and Clark A (2018). Identification and characterisation of a small-molecule ACTH receptor/Melanocortin-2-receptor antagonist. Endocrine Abstracts  10.1530/endoabs.58.oc4.4
Bruschetta G, Kim JD, Diano S and CHAN L (2018). Overexpression of Melanocortin 2 Receptor Accessory Protein 2 (MRAP2) in adult paraventricular MC4R neurons regulates energy intake and expenditure. Elsevier  Molecular Metabolism  10.1016/j.molmet.2018.09.010
Novoselova TV, Chan LF and Clark AJL (2018). Pathophysiology of melanocortin receptors and their accessory proteins. Best Pract Res Clin Endocrinol Metab  vol. 32, (2) 93-106. 10.1016/j.beem.2018.02.002

2017

Clark AJL and Chan LF (2017). Promiscuity among the MRAPs. Bioscientifica  Journal of Molecular Endocrinology  vol. 58, (3) F1-F4. 10.1530/JME-17-0002

2016

CHAN L (2016). A central role for melanocortin-4 receptors in offspring hypertension arising from maternal obesity. National Academy of Sciences  Proceedings of The National Academy of Sciences of Usa  10.1073/pnas.1607464113
Clark AJ, Forfar R, Hussain M, Jerman J, McIver E, Taylor D and Chan L (2016). ACTH Antagonists. Frontiers Media  Frontiers in Endocrinology  vol. 7, 10.3389/fendo.2016.00101
Novoselova TV, Larder R, Rimmington D, Lelliott C, Wynn E, Gorrigan RJ, Tate P, Guasti L, Sanger Mouse Genetics Project T, O'Rahilly S, Clark AJL, Logan DW, Coll AP and Chan LF (2016). Loss of Mrap2 is associated with Sim 1 deficiency and increased circulating cholesterol. Journal of Endocrinology  JOE-16-0057-JOE-16-0057. 10.1530/JOE-16-0057

2015

Buonocore F, Chan L, Achermann J and Metherell L (2015). Molecular diagnosis of patients with adrenal insufficiency using a targeted custom Haloplex next-generation sequencing panel. Endocrine Abstracts  10.1530/endoabs.38.oc3.1
Chan LF, Campbell DC, Novoselova TV, Clark AJL and Metherell LA (2015). Whole-Exome Sequencing in the Differential Diagnosis of Primary Adrenal Insufficiency in Children. Frontiers in Endocrinology  vol. 6, 10.3389/fendo.2015.00113
Novoselova TV, Rath SR, Carpenter K, Pachter N, Dickinson JE, Price G, Chan LF, Choong CS and Metherell LA (2015). NNT Pseudoexon Activation as a Novel Mechanism for Disease in Two Siblings With Familial Glucocorticoid Deficiency. Endocrine Society  Journal of Clinical Endocrinology & Metabolism  vol. 100, (2) E350-E354. 10.1210/jc.2014-3641
Jackson DS, Ramachandrappa S, Clark AJ and Chan LF (2015). Melanocortin receptor accessory proteins in adrenal disease and obesity. Frontiers in Neuroscience  vol. 9, (MAY) 10.3389/fnins.2015.00213

2014

Novoselova T, Larder R, Rimmington D, Lelliott C, Wynn E, O'Rahilly S, Clark A, Logan D, Coll A and Chan L (2014). Melanocortin 2 receptor accessory protein 2 (Mrap2) regulates hypothalamic melanocortin-4-receptor trafficking in vivo. Endocrine Abstracts  10.1530/endoabs.36.p60
Chan L, Novoselova T, Rath S, Carpenter K, Pachter N, Price G, Dickinson J, Choong C and Metherell L (2014). cDNA analysis reveals NNT pseudoexon activation in two siblings with familial glucocorticoid deficiency. Endocrine Abstracts  10.1530/endoabs.36.p4
Novoselova T, Spoudeas H, Huebner A, Cheetham T, Chan L and Metherell L (2014). Varied clinical presentations of six patients with mutations in CYP11A1 encoding the cholesterol side-chain cleavage enzyme, P450scc. Endocrine Abstracts  10.1530/endoabs.36.p12
Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJL, Storr HL and Metherell LA (2014). Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab  vol. 99, (8) E1556-E1563. 10.1210/jc.2013-3844

2013

Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstråle M, Marcus C, Hirschhorn JN, Keogh JM, O’Rahilly S, CHAN L, Clark AJ, Farooqi IS and Majzoub JA (2013). Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity. American Association For The Advancement of Science  Science  vol. 341, (6143) 275-278. 10.1126/science.1233000
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Mol Cell Endocrinol  vol. 371, (1-2) 195-200. 10.1016/j.mce.2012.12.010
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Molecular and Cellular Endocrinology  vol. 371, (1-2) 195-200. 10.1016/j.mce.2012.12.010
Novoselova TV, Jackson D, Campbell DC, Clark AJL and Chan LF (2013). Melanocortin receptor accessory proteins in adrenal gland physiology and beyond. J Endocrinol  vol. 217, (1) R1-11. 10.1530/JOE-12-0501
Prasad R, Hughes C, Chan L, Peters C, Nathwani N, Clark A, Storr H and Metherell L (2013). A mutation in thioredoxin reductase 2 (TXNRD2) is associated with a predominantly adrenal phenotype in humans. Endocrine Abstracts  1-1. 10.1530/endoabs.31.oc2.5
Meimaridou E, Hughes CR, Kowalczyk J, Chan LF, Clark AJL and Metherell LA (2013). ACTH resistance: genes and mechanisms. Endocr Dev  vol. 24, 57-66. 10.1159/000342504
Ramachandrappa S, Gorrigan RJ, Clark AJL and Chan LF (2013). The melanocortin receptors and their accessory proteins. Front Endocrinol (Lausanne)  vol. 4, 10.3389/fendo.2013.00009
Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstråle M, Marcus C, Hirschhorn JN, Keogh JM, O'Rahilly S, Chan LF, Clark AJ, Farooqi IS and Majzoub JA (2013). Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science  vol. 341, (6143) 275-278. 10.1126/science.1233000

2011

Jain V, Metherell LA, David A, Sharma R, Sharma PK, Clark AJL and Chan LF (2011). Neonatal presentation of familial glucocorticoid deficiency resulting from a novel splice mutation in the melanocortin 2 receptor accessory protein. Eur J Endocrinol  vol. 165, (6) 987-991. 10.1530/EJE-11-0581
Chan LF, Metherell LA and Clark AJL (2011). Effects of melanocortins on adrenal gland physiology. Eur J Pharmacol  vol. 660, (1) 171-180. 10.1016/j.ejphar.2010.11.041
Gorrigan RJ, Guasti L, King P, Clark AJ and Chan LF (2011). Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland. J Mol Endocrinol  vol. 46, (3) 227-232. 10.1530/JME-11-0011
Chan LF, Vaidya M, Westphal B, Allgrove J, Martin L, Afshar F, Hindmarsh PC, Savage MO, Grossman AB and Storr HL (2011). Use of intravenous etomidate to control acute psychosis induced by the hypercortisolaemia in severe paediatric Cushing's disease. Horm Res Paediatr  vol. 75, (6) 441-446. 10.1159/000324419

2010

Chan L, Albertsson-Wikland K, Camacho-Hübner C and Hochberg Z (2010). Signal transduction in child health: closing the gap between clinical and basic research. Sci Signal  vol. 3, (143) 10.1126/scisignal.3143mr3
Chung T-TLL, Chan LF, Metherell LA and Clark AJL (2010). Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2. Clin Endocrinol (Oxf)  vol. 72, (5) 589-594. 10.1111/j.1365-2265.2009.03663.x
Dias RP, Kumaran A, Chan LF, Martin L, Afshar F, Matson M, Plowman PN, Monson JP, Besser GM, Grossman AB, Savage MO and Storr HL (2010). Diagnosis, management and therapeutic outcome in prepubertal Cushing's disease. Eur J Endocrinol  vol. 162, (3) 603-609. 10.1530/EJE-09-0509
Dias RP, Chan LF, Metherell LA, Pearce SHS and Clark AJL (2010). Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency. Eur J Endocrinol  vol. 162, (2) 357-359. 10.1530/EJE-09-0720
Savage MO, Dias RP, Chan LF, Afshar F, Plowman PN, Matson M, Grossman AB and STORR HL (2010). Diagnosis and Treatment of Cushing’s Disease in Children. Pediatric Neuroendocrinology , Editors: Loche S, Cappa M, Ghizzoni L, Maghnie M and Savage MO. Karger Publishers  10.1159/000262535
Savage MO, Dias RP, Chan LF, Afshar F, Plowman NP, Matson M, Grossman AB and Storr HL (2010). Diagnosis and treatment of Cushing's disease in children. Endocr Dev  vol. 17, 134-145. 10.1159/000262535

2009

Chan LF, Metherell LA, Krude H, Ball C, O'Riordan SMP, Costigan C, Lynch SA, Savage MO, Cavarzere P and Clark AJL (2009). Homozygous nonsense and frameshift mutations of the ACTH receptor in children with familial glucocorticoid deficiency (FGD) are not associated with long-term mineralocorticoid deficiency. Clin Endocrinol (Oxf)  vol. 71, (2) 171-175. 10.1111/j.1365-2265.2008.03511.x
Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M, Elphick MR, Cheetham ME, Metherell LA and Clark AJL (2009). MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A  vol. 106, (15) 6146-6151. 10.1073/pnas.0809918106
Chan LF, Chung T-T, Massoud AF, Metherell LA and Clark AJL (2009). Functional consequence of a novel Y129C mutation in a patient with two contradictory melanocortin-2-receptor mutations. Eur J Endocrinol  vol. 160, (4) 705-710. 10.1530/EJE-08-0636
Clark AJL, Chan LF, Chung T-T and Metherell LA (2009). The genetics of familial glucocorticoid deficiency. Best Pract Res Clin Endocrinol Metab  vol. 23, (2) 159-165. 10.1016/j.beem.2008.09.006
Cooray SN, Chan L, Webb TR, Metherell L and Clark AJL (2009). Accessory proteins are vital for the functional expression of certain G protein-coupled receptors. Mol Cell Endocrinol  vol. 300, (1-2) 17-24. 10.1016/j.mce.2008.10.004
Webb TR, Chan L, Cooray SN, Cheetham ME, Chapple JP and Clark AJL (2009). Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking. Endocrinology  vol. 150, (2) 720-726. 10.1210/en.2008-0941
Metherell LA, Chung TT, Chan LF and Clark AJL (2009). Genotype:phenotype relationships in familial glucocorticoid deficiency types 1 and 2. Horm Res  vol. 72, 211-211.
Chan LF, David A, Jain V, Clark AJL and Metherell LA (2009). A novel splice mutation (IVSds3+3insTA) in the melanocortin 2 receptor accessory protein that leads to skipping of exon 3. Horm Res  vol. 72, 70-70.
Dias RP, Kumaran A, Chan LF, Martin L, Afshar F, Matson M, Plowman PN, Monson JP, Besser GM, Grossman AB, Savage MO and Storr HL (2009). Prepubertal Cushing's disease: diagnosis, management and therapeutic outcome. Hormone Research  vol. 72, 72-72.
Chan LF, Metherell LA, Krude H, Ball C, O'Riordan SM, Costigan C, Lynch SA, Savage MO, Cavarzere P and Clark AJ (2009). Homozygous nonsense and frameshift mutations of the ACTH receptor in children with familial glucocorticoid deficiency (FGD) are not associated with long-term mineralocorticoid deficiency. Clin Endocrinol (Oxf)  vol. 71, (2) 171-175. 10.1111/j.1365-2265.2008.03511.x

2008

Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP and Clark AJL (2008). The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface. J Clin Endocrinol Metab  vol. 93, (12) 4948-4954. 10.1210/jc.2008-1744
Savage MO, Chan LF, Grossman AB and Storr HL (2008). Work-up and management of paediatric Cushing's syndrome. Curr Opin Endocrinol Diabetes Obes  vol. 15, (4) 346-351. 10.1097/MED.0b013e328305082f
O'Riordan SMP, Lynch SA, Hindmarsh PC, Chan LF, Clark AJL and Costigan C (2008). A novel variant of familial glucocorticoid deficiency prevalent among the Irish traveler population. J Clin Endocr Metab  vol. 93, (7) 2896-2899. 10.1210/jc.2008-0034
O'Riordan SMP, Lynch SA, Hindmarsh PC, Chan LF, Clark AJL and Costigan C (2008). A novel variant of familial glucorticoid deficiency prevalent among the Irish traveler population. J Clin Endocrinol Metab.  vol. 93, (7) 2896-2899. 10.1210/jc.2008-0034
Chan LF, Clark AJL and Metherell LA (2008). Familial glucocorticoid deficiency: advances in the molecular understanding of ACTH action. Horm Res  vol. 69, (2) 75-82. 10.1159/000111810
Cooray SN, Chan L, Metherell L, Storr H and Clark AJL (2008). Adrenocorticotropin resistance syndromes. Endocr Dev  vol. 13, 99-116. 10.1159/000134828
Storr H, Alexandraki K, Chan L, Martin L, Monson J, Besser M, Grossman A and Savage M (2008). Comparisons in the epidemiology and diagnostic features between paediatric and adult Cushing's disease. Horm Res  vol. 70, 24-25.
Chan L, Chung TT, Massoud A, Metherell L and Clark A (2008). Functional consequence of two opposing MC2R mutations in a child with severe FGD phenotype. Horm Res  vol. 70, 23-23.
Savage MO, Chan LF, Afshar F, Plowman PN, Grossman AB and Storr HL (2008). Advances in the management of paediatric Cushing's disease. Horm Res  vol. 69, (6) 327-333. 10.1159/000117388

2007

Chan LF, Storr HL, Grossman AB and Savage MO (2007). Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment. Arq Bras Endocrinol Metabol  vol. 51, (8) 1261-1271. 10.1590/s0004-27302007000800012
Storr HL, Chan LF, Grossman AB and Savage MO (2007). Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances. Trends Endocrin Met  vol. 18, (4) 167-174. 10.1016/j.tem.2007.03.006
Chan LF, Storr HL, Plowman PN, Perry LA, Besser GM, Grossman AB and Savage MO (2007). Long-term anterior pituitary function in patients with paediatric Cushing's disease treated with pituitary radiotherapy. Eur J Endocrinol  vol. 156, (4) 477-482. 10.1530/EJE-06-0588
Savage MO, Storr HL, Chan LF and Grossman AB (2007). Diagnosis and treatment of pediatric Cushing's disease. Pituitary  vol. 10, (4) 365-371. 10.1007/s11102-007-0056-4

2006

Metherell LA, Chan LF and Clark AJL (2006). The genetics of ACTH resistance syndromes. Best Pract Res Clin Endocrinol Metab  vol. 20, (4) 547-560. 10.1016/j.beem.2006.09.002
Chan L, Storr H, Plowman PN, Perry L, Monson J, Besser GM, Grossman A and Savage M (2006). Anterior pituitary function in the long-term follow-up of five paediatric Cushing's disease patients treated with pituitary radiotherapy. Horm Res  vol. 65, 186-186.

2004

Chan LF, Storr HL, Scheimberg I, Perry LA, Banerjee K, Miraki-Moud F, Camacho-Hubner C and Savage MO (2004). Pseudo-precocious puberty caused by a juvenile granulosa cell tumor secreting androstenedione, inhibin and insulin-like growth factor-I. J Pediatr Endocr Met  vol. 17, (4) 679-684. 10.1515/jpem.2004.17.4.679
Chan L and Hodes D (2004). When is an abnormal frenulum a sign of child abuse? Arch Dis Child  vol. 89, (3) 10.1136/adc.2003.031534

Grants

Grants of specific relevance to Predictive in vitro Models
Cell DIVE Imager for automated, single cell, multiplexed immunofluorescence microscopy
Bishop CL, Bourke CD, Chan LF, Dalli J, Graham TA, Licenikova Horejsi Z, Martin-Duran JM, Nourshargh S, Prendergast A and Riches J
£340,339 Wellcome Trust (20-11-2021 - 19-11-2026)
Summary
Molecular characterisation of MC2R/MRAP antagonists for the treatment of ACTH excess in pituitary and neuroendocrine tumours.
Chan LF and Popat D
Medical Research Council (24-09-2020 - 31-03-2024)
Summary
An interdisciplinary ageing alliance: cellular metabolism over a life-course in socioeconomic disadvantaged populations
Henson S, Chan LF, Courtin E and Vasilaki A
£202,431 Biotechnology and Biological Sciences Research Council (14-02-2022 - 13-02-2024)
Summary


Improved genetic diagnosis of primary adrenal insufficiency
Storr HL, Metherell LA and Chan L
£500,199 Barts Charity (01-08-2018 - 31-07-2022)
Adrenal dysfunction and obesity in Down Syndrome
Chan LF
£99,984 Wellcome Trust (20-01-2020 - 20-10-2021)
Summary
The role of MRAPs in the control of melanocortin receptor dependent energy homeostasis and adrenal function
Chan LF
£1,025,346 Medical Research Council (04-01-2010 - 07-08-2017)
Summary
MRAP2 (Melanocortin Receptor Accessory Protein Two) and its role in melanocortin receptor trafficking and expression
Chan LF
£130,934 Medical Research Council (04-09-2006 - 03-09-2008)
Summary