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Prof Kairbaan Hodivala-Dilke

Kairbaan Hodivala-Dilke
Barts Cancer Institute
Faculty of Medicine and Dentistry, Queen Mary University of London
+44 (0)20 7882 3576



modelling the TME for human relevant therapy tests


Publications of specific relevance to Predictive in vitro Models


Newport EL, Pedrosa AR, Njegic A, Hodivala-Dilke KM and Muñoz-Félix JM (2021). Improved immunotherapy efficacy by vascular modulation. Cancers  vol. 13, (20) 10.3390/cancers13205207
Lees DM, Reynolds LE, Pedrosa AR, Roy-Luzarraga M and Hodivala-Dilke KM (2021). Phosphorylation of pericyte FAK-Y861 affects tumour cell apoptosis and tumour blood vessel regression. Angiogenesis  vol. 24, (3) 471-482. 10.1007/s10456-021-09776-8
Lees DM, Reynolds LE, Pedrosa AR, Roy-Luzarraga M and Hodivala-Dilke KM (2021). Correction to: Phosphorylation of pericyte FAK‑Y861 affects tumour cell apoptosis and tumour blood vessel regression (Angiogenesis, (2021), 24, 3, (471-482), 10.1007/s10456-021-09776-8). Angiogenesis  vol. 24, (3) 483-487. 10.1007/s10456-021-09802-9
Delvecchio FR, Fincham REA, Spear S, Clear A, Roy-Luzarraga M, Balkwill FR, Gribben JG, Bombardieri M, Hodivala-Dilke K, Capasso M and Kocher HM (2021). Pancreatic Cancer Chemotherapy Is Potentiated by Induction of Tertiary Lymphoid Structures in Mice. Cellular and Molecular Gastroenterology and Hepatology  vol. 12, (5) 1543-1565. 10.1016/j.jcmgh.2021.06.023
Newport E, Pedrosa AR, Lees D, Dukinfield M, Carter E, Gomez-Escudero J, Casado P, Rajeeve V, Reynolds LE, R Cutillas P, Duffy SW, De Luxán Delgado B and Hodivala-Dilke K (2021). Elucidating the role of the kinase activity of endothelial cell focal adhesion kinase in angiocrine signalling and tumour growth. Journal of Pathology  10.1002/path.5833


Lechertier T, Reynolds LE, Kim H, Pedrosa AR, Gómez-Escudero J, Muñoz-Félix JM, Batista S, Dukinfield M, Demircioglu F, Wong PP, Matchett KP, Henderson NC, D’Amico G, Parsons M, Harwood C, Meier P and Hodivala-Dilke KM (2020). Pericyte FAK negatively regulates Gas6/Axl signalling to suppress tumour angiogenesis and tumour growth. Nature Communications  vol. 11, (1) 10.1038/s41467-020-16618-6
Roy-Luzarraga M, Reynolds L and Hodivala-Dilke K (2020). Regulation of tumour progression and metastasis by Endothelial-FAK upon chemotherapy treatment. Pancreatology  vol. 20, (8) 10.1016/j.pan.2018.10.036
Roy-Luzarraga M, Abdel-Fatah T, Reynolds LE, Clear A, Taylor JG, Gribben JG, Chan S, Jones L and Hodivala-Dilke K (2020). Association of Low Tumor Endothelial Cell pY397-Focal Adhesion Kinase Expression With Survival in Patients With Neoadjuvant-Treated Locally Advanced Breast Cancer. Jama Network Open  vol. 3, (10) 10.1001/jamanetworkopen.2020.19304
Wong PP, Muñoz-Félix JM, Hijazi M, Kim H, Robinson SD, De Luxán-Delgado B, Rodríguez-Hernández I, Maiques O, Meng YM, Meng Q, Bodrug N, Dukinfield MS, Reynolds LE, Elia G, Clear A, Harwood C, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Matchett KP, Henderson NC, Szlosarek PW, Dreger SA, Smith S, Jones JL, Gribben JG, Cutillas PR and Meier P (2020). Cancer Burden Is Controlled by Mural Cell-β3-Integrin Regulated Crosstalk with Tumor Cells. Cell  vol. 181, (6) 1346-1363.e21. 10.1016/j.cell.2020.02.003
Pari AAA, Singhal M, Hubers C, Mogler C, Schieb B, Gampp A, Gengenbacher N, Reynolds LE, Terhardt D, Geraud C, Utikal J, Thomas M, Goerdt S, Hodivala-Dilke KM, Augustin HG and Felcht M (2020). Tumor cell–derived angiopoietin-2 promotes metastasis in Melanoma. Cancer Research  vol. 80, (12) 2586-2598. 10.1158/0008-5472.CAN-19-2660
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J, Newport E, Rajeeve V, Baker A-M, Roy-Luzarraga M, Graham TA, Foster J, Wang Y, Campbell JJ, Singh R, Zhang P, Schall TJ, Balkwill FR, Sosabowski J, Cutillas PR, Frezza C, Sancho P and Hodivala-Dilke K (2020). Cancer associated fibroblast FAK regulates malignant cell metabolism. Nature Research (Part of Springer Nature)  Nature Communications  vol. 11, (1) 1290-1290. 10.1038/s41467-020-15104-3
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS and Hobbs AJ (2020). C-type natriuretic peptide co-ordinates cardiac structure and function. European Heart Journal  vol. 41, (9) 1006-1020. 10.1093/eurheartj/ehz093
(2020). “Splitting the matrix”: intussusceptive angiogenesis meets MT1-MMP. Embo Molecular Medicine  vol. 12, (2) 10.15252/emmm.201911663
Wilcz-Villega E, Carter E, Ironside A, Xu R, Mataloni I, Holdsworth J, Jones W, Moreno Béjar R, Uhlik L, Bentham RB, Godinho SA, Dalli J, Grose R, Szabadkai G, Jones L, Hodivala-Dilke K and Bianchi K (2020). Macrophages induce malignant traits in mammary epithelium via IKKε/TBK1 kinases and the serine biosynthesis pathway. Embo Molecular Medicine  vol. 12, (2) 10.15252/emmm.201910491


Li J, Fukase Y, Shang Y, Zou W, Muñoz-Félix JM, Buitrago L, Van Agthoven J, Zhang Y, Hara R, Tanaka Y, Okamoto R, Yasui T, Nakahata T, Imaeda T, Aso K, Zhou Y, Locuson C, Nesic D, Duggan M, Takagi J, Vaughan RD, Walz T, Hodivala-Dilke K, Teitelbaum SL, Arnaout MA, Filizola M, Foley MA and Coller BS (2019). Novel Pure αvβ3 Integrin Antagonists That Do Not Induce Receptor Extension, Prime the Receptor, or Enhance Angiogenesis at Low Concentrations. Acs Pharmacology and Translational Science  vol. 2, (6) 387-401. 10.1021/acsptsci.9b00041
(2019). Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. Journal of Pathology  vol. 249, (4) 523-535. 10.1002/path.5340
(2019). Single-cell transcriptome analyses reveal novel targets modulating cardiac neovascularization by resident endothelial cells following myocardial infarction. European Heart Journal  vol. 40, (30) 2507-2520. 10.1093/eurheartj/ehz305
Pedrosa A-R, BODRUG N, Gomez-Escudero J, Carter EP, Reynolds LE, Georgiou PN, Fernandez I, Lees DM, Kostourou V, Alexopoulou AN, Batista S, Tavora B, Serrels B, Parsons M, Iskratsch T and Hodivala-Dilke K (2019). Tumour angiogenesis is differentially regulated by endothelial cell Focal Adhesion Kinase tyrosine-397 and -861 phosphorylation. American Association For Cancer Research  Cancer Research  10.1158/0008-5472.CAN-18-3934


Foxler DE, Bridge KS, Foster JG, Grevitt P, Curry S, Shah KM, Davidson KM, Nagano A, Gadaleta E, Rhys HI, Kennedy PT, Hermida MA, Chang T-Y, Shaw PE, Reynolds LE, McKay TR, Wang H-W, Ribeiro PS, Plevin MJ, Lagos D, Lemoine NR, Rajan P, Graham TA, Chelala C, Hodivala-Dilke KM, Spendlove I and Sharp TV (2018). A HIF-LIMD1 negative feedback mechanism mitigates the pro-tumorigenic effects of hypoxia. Embo Mol Med  10.15252/emmm.201708304


Weinmüller M, Rechenmacher F, Kiran Marelli U, Reichart F, Kapp TG, Räder AFB, Di Leva FS, Marinelli L, Novellino E, Muñoz-Félix JM, Hodivala-Dilke K, Schumacher A, Fanous J, Gilon C, Hoffman A and Kessler H (2017). Overcoming the Lack of Oral Availability of Cyclic Hexapeptides: Design of a Selective and Orally Available Ligand for the Integrin αvβ3. Angewandte Chemie - International Edition  vol. 56, (51) 16405-16409. 10.1002/anie.201709709
(2017). Focal Adhesion Kinase (FAK) tyrosine 397E mutation restores the vascular leakage defect in endothelium-specific FAK-kinase dead mice. Journal of Pathology  vol. 242, (3) 358-370. 10.1002/path.4911
Ross JA, Webster RG, Lechertier T, Reynolds LE, Turmaine M, Bencze M, Jamshidi Y, Cetin H, Muntoni F, Beeson D, Hodilvala-Dilke K and Conti FJ (2017). Multiple roles of integrin-α3 at the neuromuscular junction. J Cell Sci  vol. 130, (10) 1772-1784. 10.1242/jcs.201103
(2017). Dual role of pericyte α6β1-integrin in tumour blood vessels. Journal of Cell Science  vol. 130, (9) 1583-1595. 10.1242/jcs.197848
(2017). Correction: A Promyelocytic Leukemia Protein-Thrombospondin-2 Axis and the Risk of Relapse in Neuroblastoma. Clin Cancer Res  vol. 23, (3) 10.1158/1078-0432.CCR-16-2605


Wong PP, Bodrug N and Hodivala-Dilke KM (2016). Exploring Novel Methods for Modulating Tumor Blood Vessels in Cancer Treatment. Current Biology  vol. 26, (21) R1161-R1166. 10.1016/j.cub.2016.09.043
Demircioglu F and Hodivala-Dilke K (2016). αvβ3 Integrin and tumour blood vessels — learning from the past to shape the future. Current Opinion in Cell Biology  vol. 42, 121-127. 10.1016/
Roy-Luzarraga M and Hodivala-Dilke K (2016). Molecular Pathways: Endothelial Cell FAK--A Target for Cancer Treatment. American Association For Cancer Research  Clinical Cancer Research  vol. 22, (15) 3718-3724. 10.1158/1078-0432.CCR-14-2021
Di Maggio F, Arumugam P, Delvecchio FR, Batista S, Lechertier T, Hodivala-Dilke K and Kocher HM (2016). Pancreatic stellate cells regulate blood vessel density in the stroma of pancreatic ductal adenocarcinoma. Elsevier  Pancreatology  10.1016/j.pan.2016.05.393
Dvorkina M, Nieddu V, Chakelam S, Pezzolo A, Cantilena S, Leite AP, Chayka O, Regad T, Pistorio A, Sementa AR, Virasami A, Barton J, Montano X, Lechertier T, Brindle N, Morgenstern D, LE Bras M, Burns A, Saunders N, Hodivala-Dilke K, Bagella L, de The H, Anderson J, Sebire N, Pistoia V, Sala A and Salomoni P (2016). A promyelocytic leukemia protein-thrombospondin 2 axis and the risk of relapse in neuroblastoma. American Association For Cancer Research  Clinical Cancer Research  10.1158/1078-0432.CCR-15-2081


(2015). Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC. J Natl Cancer Inst  vol. 108, (1) 10.1093/jnci/djv293
Gopinathan G, Milagre C, Pearce OMT, Reynolds LE, Hodivala-Dilke K, Leinster DA, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Interleukin-6 stimulates defective angiogenesis. Cancer Research  vol. 75, (15) 3098-3107. 10.1158/0008-5472.CAN-15-1227
Gopinathan G, Milagre C, Pearce OMT, Reynolds L, Hodivala-Dilke K, Leinster A, Zhong H, Hollingsworth RE, Thompson R, Whiteford JR and Balkwill F (2015). Abstract 4162: Interleukin–6 stimulates defective angiogenesis. 10.1158/1538-7445.am2015-4162
Wong PP, Demircioglu F, Ghazaly E, Alrawashdeh W, Stratford MRL, Scudamore CL, Cereser B, Crnogorac-Jurcevic T, McDonald S, Elia G, Hagemann T, Kocher HM and Hodivala-Dilke KM (2015). Dual-action combination therapy enhances angiogenesis while reducing tumor growth and spread. Cancer Cell  vol. 27, (1) 123-137. 10.1016/j.ccell.2014.10.015
Birdsey GM, Shah AV, Dufton N, Reynolds LE, Almagro LO, Yang Y, Aspalter IM, Khan ST, Mason JC, Dejana E, Göttgens B, Hodivala-Dilke K, Gerhardt H, Adams RH and Randi AM (2015). The endothelial transcription factor erg promotes vascular stability and growth through Wnt/β-catenin signaling. Developmental Cell  vol. 32, (1) 82-96. 10.1016/j.devcel.2014.11.016


Tavora B, Batista S, Alexopoulou AN, Kostourou V, Fernandez I, Robinson SD, Lees DM, Serrels B and Hodivala-Dilke K (2014). Generation of point-mutant FAK knockin mice. Genesis  vol. 52, (11) 907-915. 10.1002/dvg.22823
Tavora B, Reynolds LE, Batista S, Demircioglu F, Fernandez I, Lechertier T, Lees DM, Wong P-P, Alexopoulou A, Elia G, Clear A, Ledoux A, Hunter J, Perkins N, Gribben JG and Hodivala-Dilke KM (2014). Endothelial-cell FAK targeting sensitizes tumours to DNA-damaging therapy. Nature  vol. 514, (7520) 112-116. 10.1038/nature13541
Batista S, Maniati E, Reynolds LE, Tavora B, Lees DM, Fernandez I, Elia G, Casanovas O, Lo Celso C, Hagemann T and Hodivala-Dilke K (2014). Haematopoietic focal adhesion kinase deficiency alters haematopoietic homeostasis to drive tumour metastasis. Nat Commun  vol. 5, 10.1038/ncomms6054
Shah AV, Birdsey GM, Reynolds LE, Dufton N, Almagro LO, Yang Y, Aspalter IM, Khan ST, Mason JC, Dejana E, Goettgens B, Hodivala-Dilke K, Gerhardt H, Adams RH and Randi AM (2014). The endothelial transcription factor ERG promotes vascular stability and growth through Wnt/beta-catenin signaling. Angiogenesis  vol. 17, (3) 715-715.
Alexopoulou AN, Ho-Yen CM, Papalazarou V, Elia G, Jones JL and Hodivala-Dilke K (2014). Tumour-associated endothelial-FAK correlated with molecular sub-type and prognostic factors in invasive breast cancer. Bmc Cancer  vol. 14, 10.1186/1471-2407-14-237
Steri V, Ellison TS, Gontarczyk AM, Weilbaecher K, Schneider JG, Edwards D, Fruttiger M, Hodivala-Dilke KM and Robinson SD (2014). Acute depletion of endothelial β3-integrin transiently inhibits tumor growth and angiogenesis in mice. American Heart Association  Circulation Research  vol. 114, (1) 79-91. 10.1161/CIRCRESAHA.114.301591


Martino-Echarri E, Fernández-Rodríguez R, Rodríguez-Baena FJ, Barrientos-Durán A, Torres-Collado AX, Plaza-Calonge MDC, Amador-Cubero S, Cortés J, Reynolds LE, Hodivala-Dilke KM and Rodríguez-Manzaneque JC (2013). Contribution of ADAMTS1 as a tumor suppressor gene in human breast carcinoma. Linking its tumor inhibitory properties to its proteolytic activity on nidogen-1 and nidogen-2. Int J Cancer  vol. 133, (10) 2315-2324. 10.1002/ijc.28271
Ma Y, Reynolds LE, Li A, Stevenson RP, Hodivala-Dilke KM, Yamashiro S and Machesky LM (2013). Fascin 1 is dispensable for developmental and tumour angiogenesis. Biol Open  vol. 2, (11) 1187-1191. 10.1242/bio.20136031
Jones DT, Lechertier T, Reynolds LE, Mitter R, Robinson SD, Kirn-Safran CB and Hodivala-Dilke KM (2013). Endogenous ribosomal protein L29 (RPL29): a newly identified regulator of angiogenesis in mice. Dis Model Mech  vol. 6, (1) 115-124. 10.1242/dmm.009183
Baker M, Reynolds LE, Robinson SD, Lees DM, Parsons M, Elia G and Hodivala-Dilke K (2013). Stromal Claudin14-heterozygosity, but not deletion, increases tumour blood leakage without affecting tumour growth. Plos One  vol. 8, (5) 10.1371/journal.pone.0062516
Kostourou V, Lechertier T, Reynolds LE, Lees DM, Baker M, Jones DT, Tavora B, Ramjaun AR, Birdsey GM, Robinson SD, Parsons M, Randi AM, Hart IR and Hodivala-Dilke K (2013). FAK-heterozygous mice display enhanced tumour angiogenesis. Nat Commun  vol. 4, 10.1038/ncomms3020


Lechertier T and Hodivala-Dilke K (2012). Focal adhesion kinase and tumour angiogenesis. J Pathol  vol. 226, (2) 404-412. 10.1002/path.3018
Jones DT, Lechertier T, Mitter R, Herbert JMJ, Bicknell R, Jones JL, Li J-L, Buffa F, Harris AL and Hodivala-Dilke K (2012). Gene expression analysis in human breast cancer associated blood vessels. Plos One  vol. 7, (10) 10.1371/journal.pone.0044294


(2011). Use of the mouse aortic ring assay to study angiogenesis. Nat Protoc  vol. 7, (1) 89-104. 10.1038/nprot.2011.435
Robinson SD and Hodivala-Dilke KM (2011). The role of β3-integrins in tumor angiogenesis: context is everything. Curr Opin Cell Biol  vol. 23, (5) 630-637. 10.1016/
Hodivala-Dilke KM (2011). Abstract SY16-03: Dose matters and angiogenesis. 10.1158/1538-7445.am2011-sy16-03
Baker M, Robinson SD, Hodivala-Dilke K and Ben-Yosef T (2011). Abstract 3479: Claudin-14: A novel regulator of angiogenesis. 10.1158/1538-7445.am2011-3479
Batista SA, Reynolds L, Tavora B and Hodivala-Dilke K (2011). Abstract 517: Deficiency of FAK in the bone marrow compartment enhances tumour metastasis. 10.1158/1538-7445.am2011-517
Hodivala-Dilke KM (2011). Dose matters and angiogenesis. Cancer Research  vol. 71,
Tavora B, Batista S and Hodivala-Dilke K (2011). Measuring angiogenesis in mice. Methods Mol Biol  vol. 769, 351-358. 10.1007/978-1-61779-207-6_23


Tavora B, Batista S, Reynolds LE, Jadeja S, Robinson S, Kostourou V, Hart I, Fruttiger M, Parsons M and Hodivala-Dilke KM (2010). Endothelial FAK is required for tumour angiogenesis. Embo Mol Med  vol. 2, (12) 516-528. 10.1002/emmm.201000106
da Silva RG, Tavora B, Robinson SD, Reynolds LE, Szekeres C, Lamar J, Batista S, Kostourou V, Germain MA, Reynolds AR, Jones DT, Watson AR, Jones JL, Harris A, Hart IR, Iruela-Arispe ML, Dipersio CM, Kreidberg JA and Hodivala-Dilke KM (2010). Endothelial alpha3beta1-integrin represses pathological angiogenesis and sustains endothelial-VEGF. Am J Pathol  vol. 177, (3) 1534-1548. 10.2353/ajpath.2010.100043
(2010). Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome (Corrigendum). Nature  vol. 466, (7304) 10.1038/nature09281
(2010). Tumour angiogenesis is reduced in the Tc1 mouse model of Down's syndrome. Nature  vol. 465, (7299) 813-817. 10.1038/nature09106
Worth DC, Hodivala-Dilke K, Robinson SD, King SJ, Morton PE, Gertler FB, Humphries MJ and Parsons M (2010). Alpha v beta3 integrin spatially regulates VASP and RIAM to control adhesion dynamics and migration. J Cell Biol  vol. 189, (2) 369-383. 10.1083/jcb.200912014
(2010). Endothelial-Rac1 is not required for tumor angiogenesis unless alphavbeta3-integrin is absent. Plos One  vol. 5, (3) 10.1371/journal.pone.0009766
Watson AR, Pitchford SC, Reynolds LE, Direkze N, Brittan M, Alison MR, Rankin S, Wright NA and Hodivala-Dilke KM (2010). Deficiency of bone marrow beta3-integrin enhances non-functional neovascularization. J Pathol  vol. 220, (4) 435-445. 10.1002/path.2660
(2010). Genetic ablation of the alpha 6-integrin subunit in Tie1Cre mice enhances tumour angiogenesis. J Pathol  vol. 220, (3) 370-381. 10.1002/path.2654
(2010). Regulation of lymphatic-blood vessel separation by endothelial Rac1 (vol 136, pg 4043, 2009). Development  vol. 137, (2) 359-359. 10.1242/dev.047597


Robinson SD, Reynolds LE, Kostourou V, Reynolds AR, da Silva RG, Tavora B, Baker M, Marshall JF and Hodivala-Dilke KM (2009). Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis. J Biol Chem  vol. 284, (49) 33966-33981. 10.1074/jbc.M109.030700
(2009). Regulation of lymphatic-blood vessel separation by endothelial Rac1. Development  vol. 136, (23) 4043-4053. 10.1242/dev.035014
Reynolds AR and Hodivala-Dilke KM (2009). Will integrin inhibitors have proangiogenic effects in the clinic? Reply. Nat Med  vol. 15, (7) 727-727. 10.1038/nm0709-727
Reynolds AR, Hart IR, Watson AR, Welti JC, Silva RG, Robinson SD, Da Violante G, Gourlaouen M, Salih M, Jones MC, Jones DT, Saunders G, Kostourou V, Perron-Sierra F, Norman JC, Tucker GC and Hodivala-Dilke KM (2009). Stimulation of tumor growth and angiogenesis by low concentrations of RGD-mimetic integrin inhibitors. Nat Med  vol. 15, (4) 392-400. 10.1038/nm.1941
Ramjaun AR and Hodivala-Dilke K (2009). The role of cell adhesion pathways in angiogenesis. Int J Biochem Cell Biol  vol. 41, (3) 521-530. 10.1016/j.biocel.2008.05.030


Hodivala-Dilke K (2008). alpha v beta 3 integrin and angiogenesis: a moody integrin in a changing environment. Curr Opin Cell Biol  vol. 20, (5) 514-519. 10.1016/
(2008). Integrins - The keys to unlocking angiogenesis. Arterioscl Throm Vas  vol. 28, (10) 1703-1713. 10.1161/ATVBAHA.108.172015
Schier S, Watson A, Hodivala-Dilke K and Wright NA (2008). The role of beta 3-integrin on bone marrow-derived cells in inflammatory bowel diseases. Gastroenterology  vol. 134, (4) A257-A257.
Reynolds LE, Conti FJ, Silva R, Robinson SD, Iyer V, Rudling R, Cross B, Nye E, Hart IR, Dipersio CM and Hodivala-Dilke KM (2008). alpha3beta1 integrin-controlled Smad7 regulates reepithelialization during wound healing in mice. J Clin Invest  vol. 118, (3) 965-974. 10.1172/JCI33538
Claxton S, Kostourou V, Jadeja S, Chambon P, Hodivala-Dilke K and Fruttiger M (2008). Efficient, inducible Cre-recombinase activation in vascular endothelium. Genesis  vol. 46, (2) 74-80. 10.1002/dvg.20367
Scott AN, Hetheridge C, Reynolds AR, Nayak V, Hodivala-Dilke K and Mellor H (2008). Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis. Angiogenesis  vol. 11, (4) 337-346. 10.1007/s10456-008-9115-3


Boosani CS, Mannam AP, Cosgrove D, Silva R, Hodivala-Dilke KM, Keshamouni VG and Sudhakar A (2007). Regulation of COX-2-mediated signaling by alpha 3 type IV noncollagenous domain in tumor angiogenesis. Blood  vol. 110, (4) 1168-1177. 10.1182/blood-2007-01-066282
Piqueras L, Reynolds AR, Hodivala-Dilke KM, Alfranca A, Redondo JM, Hatae T, Tanabe T, Warner TD and Bishop-Bailey D (2007). Activation of PPARbeta/delta induces endothelial cell proliferation and angiogenesis. Arterioscler Thromb Vasc Biol  vol. 27, (1) 63-69. 10.1161/01.ATV.0000250972.83623.61


Lucas M, Stuart LM, Zhang A, Hodivala-Dilke K, Febbraio M, Silverstein R, Savill J and Lacy-Hulbert A (2006). Requirements for apoptotic cell contact in regulation of macrophage responses. J Immunol  vol. 177, (6) 4047-4054. 10.4049/jimmunol.177.6.4047
Direkze NC, Jeffery R, Hodivala-Dilke K, Hunt T, Playford RJ, Elia G, Poulsom R, Wright NA and Alison MR (2006). Bone marrow-derived stromal cells express lineage-related messenger RNA species. Cancer Res  vol. 66, (3) 1265-1269. 10.1158/0008-5472.CAN-05-3202
Robinson SD, Wilson S and Hodivala-Dilke KM (2006). Generation of genetically modified embryonic stem cells for the development of knockout mouse animal model systems. Methods Mol Med  vol. 120, 465-477. 10.1385/1-59259-969-9:465
Reynolds LE and Hodivala-Dilke KM (2006). Primary mouse endothelial cell culture for assays of angiogenesis. Methods Mol Med  vol. 120, 503-509. 10.1385/1-59259-969-9:503


Fang J, Hodivala-Dilke K, Johnson BD, Du LM, Hynes RO, White GC and Wilcox DA (2005). Therapeutic expression of the platelet-specific integrin, alpha IIb beta 3, in a murine model for Glanzmann thrombasthenia. Blood  vol. 106, (8) 2671-2679. 10.1182/blood-2004-12-4619
Lamagna C, Hodivala-Dilke KM, Imhof BA and Aurrand-Lions M (2005). Antibody against junctional adhesion molecule-C inhibits angiogenesis and tumor growth. Cancer Res  vol. 65, (13) 5703-5710. 10.1158/0008-5472.CAN-04-4012
Reynolds LE, Conti FJ, Lucas M, Grose R, Robinson S, Stone M, Saunders G, Dickson C, Hynes RO, Lacy-Hulbert A and Hodivala-Dilke K (2005). Accelerated re-epithelialization in beta3-integrin-deficient- mice is associated with enhanced TGF-beta1 signaling. Nat Med  vol. 11, (2) 167-174. 10.1038/nm1165
Brittan M, Braun KM, Reynolds LE, Conti FJ, Reynolds AR, Poulsom R, Alison MR, Wright NA and Hodivala-Dilke KM (2005). Bone marrow cells engraft within the epidermis and proliferate in vivo with no evidence of cell fusion. J Pathol  vol. 205, (1) 1-13. 10.1002/path.1682


McLean GW, Komiyama NH, Serrels B, Asano H, Reynolds L, Conti F, Hodivala-Dilke K, Metzger D, Chambon P, Grant SGN and Frame MC (2004). Specific deletion of focal adhesion kinase suppresses tumor formation and blocks malignant progression. Genes Dev  vol. 18, (24) 2998-3003. 10.1101/gad.316304
Direkze NC, Hodivala-Dilke K, Jeffery R, Hunt T, Poulsom R, Oukrif D, Alison MR and Wright NA (2004). Bone marrow contribution to tumor-associated myofibroblasts and fibroblasts. Cancer Res  vol. 64, (23) 8492-8495. 10.1158/0008-5472.CAN-04-1708
Reynolds AR, Reynolds LE, Nagel TE, Lively JC, Robinson SD, Hicklin DJ, Bodary SC and Hodivala-Dilke KM (2004). Elevated Flk1 (vascular endothelial growth factor receptor 2) signaling mediates enhanced angiogenesis in beta3-integrin-deficient mice. Cancer Res  vol. 64, (23) 8643-8650. 10.1158/0008-5472.CAN-04-2760
Robinson SD, Reynolds LE, Wyder L, Hicklin DJ and Hodivala-Dilke KM (2004). Beta3-integrin regulates vascular endothelial growth factor-A-dependent permeability. Arterioscler Thromb Vasc Biol  vol. 24, (11) 2108-2114. 10.1161/


Mistry A, Harbottle R, Hart S and Hodivala-Dilke KM (2003). Integrins and angiogenesis: unlocking the route to gene therapy. Curr Opin Mol Ther  vol. 5, (6) 603-610.
Petiot A, Conti FJA, Grose R, Revest J-M, Hodivala-Dilke KM and Dickson C (2003). A crucial role for Fgfr2-IIIb signalling in epidermal development and hair follicle patterning. Development  vol. 130, (22) 5493-5501. 10.1242/dev.00788
Alugupalli KR, Michelson AD, Joris I, Schwan TG, Hodivala-Dilke K, Hynes RO and Leong JM (2003). Spirochete-platelet attachment and thrombocytopenia in murine relapsing fever borreliosis. Blood  vol. 102, (8) 2843-2850. 10.1182/blood-2003-02-0426
Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM and Eady RAJ (2003). Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes. J Cell Sci  vol. 116, (Pt 20) 4239-4248. 10.1242/jcs.00701
Hodivala-Dilke KM, Reynolds AR and Reynolds LE (2003). Integrins in angiogenesis: multitalented molecules in a balancing act. Cell Tissue Res  vol. 314, (1) 131-144. 10.1007/s00441-003-0774-5
Conti FJA, Rudling RJ, Robson A and Hodivala-Dilke KM (2003). alpha3beta1-integrin regulates hair follicle but not interfollicular morphogenesis in adult epidermis. J Cell Sci  vol. 116, (Pt 13) 2737-2747. 10.1242/jcs.00475
Reynolds AR, Moein Moghimi S and Hodivala-Dilke K (2003). Nanoparticle-mediated gene delivery to tumour neovasculature. Trends Mol Med  vol. 9, (1) 2-4. 10.1016/s1471-4914(02)00004-7
Direkze NC, Forbes SJ, Brittan M, Hunt T, Jeffery R, Preston SL, Poulsom R, Hodivala-Dilke K, Alison MR and Wright NA (2003). Multiple organ engraftment by bone-marrow-derived myofibroblasts and fibroblasts in bone-marrow-transplanted mice. Stem Cells  vol. 21, (5) 514-520. 10.1634/stemcells.21-5-514


Wan H, Marshall J, Reynolds LE, Stone MG, McGrath JA, Hodivala-Dilke KM and Eady RAJ (2002). Diversity of desmoplakin expression in basal palm keratinocytes: A possible clue to the identification of epidermal stem cells. J Invest Dermatol  vol. 119, (3) 714-714.
Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M and Reis e Sousa C (2002). CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells. J Immunol  vol. 168, (12) 6057-6065. 10.4049/jimmunol.168.12.6057
Francis SE, Goh KL, Hodivala-Dilke K, Bader BL, Stark M, Davidson D and Hynes RO (2002). Central roles of alpha5beta1 integrin and fibronectin in vascular development in mouse embryos and embryoid bodies. Arterioscler Thromb Vasc Biol  vol. 22, (6) 927-933. 10.1161/01.atv.0000016045.93313.f2
Brittan M, Hunt T, Jeffery R, Poulsom R, Forbes SJ, Hodivala-Dilke K, Goldman J, Alison MR and Wright NA (2002). Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon. Gut  vol. 50, (6) 752-757. 10.1136/gut.50.6.752
Forbes SJ, Hunt T, Brittan M, Jeffery R, Poulsom R, Hodivala-Dilke K, Alison MR and Wright NA (2002). Bone marrow derivation of pericryptal myofibroblasts in the mouse and human small intestine and colon. Gut  vol. 50, A35-A35.
Brittan M, Hunt T, Jeffery R, Poulsom R, Forbes S, Hodivala-Dilke K, Alison M and Wright NA (2002). Bone marrow derivation of intestinal subepithelial myofibroblasts in the mouse and human small intestine and colon. Gastroenterology  vol. 122, (4) A95-A96.
Hodivala-Dilke K (2002). Primary mouse keratinocyte culture. Methods Mol Biol  vol. 188, 139-144. 10.1385/1-59259-185-X:139
Reynolds LE, Wyder L, Lively JC, Taverna D, Robinson SD, Huang X, Sheppard D, Hynes RO and Hodivala-Dilke KM (2002). Enhanced pathological angiogenesis in mice lacking beta3 integrin or beta3 and beta5 integrins. Nat Med  vol. 8, (1) 27-34. 10.1038/nm0102-27
Hynes RO, Lively JC, McCarty JH, Taverna D, Francis SE, Hodivala-Dilke K and Xiao Q (2002). The diverse roles of integrins and their ligands in angiogenesis. Cold Spring Harb Symp Quant Biol  vol. 67, 143-153. 10.1101/sqb.2002.67.143


Hodivala-Dilke K (2001). Sticky science is skin deep. Journal of Cell Science  vol. 114, (20) 3582-3582. 10.1242/jcs.114.20.3582
Forbes SJ, Wyles SM, Ryan ED, Navaratnarasah S, Hodivala-Dilke KM, Jeffrey R, Hunt T, Alison MR, Cook T, Pusey C, Poulsom R and Wright NA (2001). Kidney from bone marrow in humans and mice. J Pathol  vol. 195, 3A-3A.
Poulsom R, Forbes SJ, Hodivala-Dilke K, Ryan E, Wyles S, Navaratnarasah S, Jeffery R, Hunt T, Alison M, Cook T, Pusey C and Wright NA (2001). Bone marrow contributes to renal parenchymal turnover and regeneration. J Pathol  vol. 195, (2) 229-235. 10.1002/path.976
Forbes SJ, Alison MR, Hodivala-Dilke KM, Jeffery R, Poulsom R and Wright NA (2001). Bone marrow stem cells make hepatocytes with replicative potential. Gastroenterology  vol. 120, (5) A62-A62. 10.1016/s0016-5085(08)80305-8
Forbes SJ, Hodivala-Dilke KM, Jeffery R, Alison MR, Poulsom R, Thomas H and Wright NA (2001). Hepatocytes derived from bone marrow stem cells demonstrate polyploidisation. J Hepatol  vol. 34, 20-21. 10.1016/s0168-8278(01)80940-5
Forbes SJ, Hodivala-Dilke KM, Jeffery R, Hunt T, Alison MR, Poulsom R and Wright NA (2001). Hepatocytes derived from bone marrow stem cells show polyploidization in humans and mice. Gut  vol. 48, A65-A66.


Lively JC, Hodivala-Dilke K and Hynes RO (2000). In vitro characterization of integrin-deficient endothelial cells and aortic explants. Mol Biol Cell  vol. 11, 51A-51A.
McHugh KP, Hodivala-Dilke K, Zheng MH, Namba N, Jonathan L, Novack D, Feng X, Ross FP, Hynes RO and Teitelbaum SL (2000). Mice lacking β3 integrins are osteosclerotic because of dysfunctional osteoclasts. Journal of Clinical Investigation  vol. 105, (4) 433-440. 10.1172/JCI8905


Hodivala-Dilke KM, McHugh KP, Tsakiris DA, Rayburn H, Crowley D, Ullman-Culleré M, Ross FP, Coller BS, Teitelbaum S and Hynes RO (1999). β3-integrin-deficient mice are a model for Glanzmann thrombasthenia showing placental defects and reduced survival. Journal of Clinical Investigation  vol. 103, (2) 229-238. 10.1172/JCI5487
Hynes RO and Hodivala-Dilke KM (1999). Insights and questions arising from studies of a mouse model of Glanzmann thrombasthenia. Thrombosis and Haemostasis  vol. 82, (2) 481-485. 10.1055/s-0037-1615868
Hynes RO, Bader BL and Hodivala-Dilke K (1999). Integrins in vascular development. Brazilian Journal of Medical and Biological Research  vol. 32, (5) 501-510. 10.1590/S0100-879X1999000500002
Tsakiris DA, Scudder L, Hodivala-Dilke K, Hynes RO and Coller BS (1999). Hemostasis in the mouse (Mus musculus): A review. Thrombosis and Haemostasis  vol. 81, (2) 177-188. 10.1055/s-0037-1614439


Hodivala-Dilke KM, DiPersio CM, Kreidberg JA and Hynes RO (1998). Novel roles for α3β1 integrin as a regulator of cytoskeletal assembly and as a trans-dominant inhibitor of integrin receptor function in mouse keratinocytes. Journal of Cell Biology  vol. 142, (5) 1357-1369. 10.1083/jcb.142.5.1357


DiPersio CM, HodivalaDilke KM, Jaenisch R, Kreidberg JA and Hynes RO (1997). alpha 3 beta 1 integrin is required for normal development of the epidermal basement membrane. J Cell Biol  vol. 137, (3) 729-742. 10.1083/jcb.137.3.729


Braga VMM, Hodivala KJ and Watt FM (1995). Calcium-induced changes in distribution and solubility of cadherins, integrins and their associated cytoplasmic proteins in human keratinocytes. Cell Communication and Adhesion  vol. 3, (3) 201-215. 10.3109/15419069509081287


Hodivala KJ, Pei XF, Liu QY, Jones PH, Rytina ERC, Gilbert C, Singer A and Watt FM (1994). Integrin expression and function in HPV16-immortalised human keratinocytes in the presence or absence of v-Ha-ras. Comparison with cervical intraepithelial neoplasia. Oncogene  vol. 9, (3) 943-948.
Watt FM and Hodivala KJ (1994). Cell Adhesion: Fibronectin and integrin knockouts come unstuck. Current Biology  vol. 4, (3) 270-272. 10.1016/S0960-9822(00)00063-4
Hodivala KJ and Watt FM (1994). Evidence that cadherins play a role in the downregulation of integrin expression that occurs during keratinocyte terminal differentiation. Journal of Cell Biology  vol. 124, (4) 589-600. 10.1083/jcb.124.4.589


Billingsley PF, Hodivala KJ, Winger LA and Sinden RE (1991). Detection of mature malaria infections in live mosquitoes. Transactions of The Royal Society of Tropical Medicine and Hygiene  vol. 85, (4) 450-453. 10.1016/0035-9203(91)90215-K


Sinden RE, Suhrbier A, Davies CS, Fleck SL, Hodivala K and Nicholas JC (1990). The development and routine application of high-density exoerythrocytic-stage cultures of Plasmodium berghei. Bulletin of The World Health Organization  vol. 68, (SUPPL.) 115-125.
(1990). A liver-stage specific antigen of P. berghei identified by a monoclonal antibody. Bulletin of The World Health Organization  vol. 68, (SUPPL.) 172-177.
(1990). An antigen specific to the liver stage of rodent malaria recognized by a monoclonal antibody. Parasite Immunology  vol. 12, (4-5) 473-481. 10.1111/j.1365-3024.1990.tb00982.x


Suhrbier A, Winger L, Newton MF, Hodivala KJ, Nicholas J, Sinden RE, Wiser MF and Harte P (1989). Contrasts in antigen expression in the erythrocytic and exoerythrocytic stages of rodent malaria. Parasitology  vol. 99, (2) 165-170. 10.1017/S0031182000058595


Grants of specific relevance to Predictive in vitro Models
Novel TLR signalling that regulates the energy status of cardiomyocytes
Hodivala-Dilke K and Shintani Y
£323,091 Medical Research Council (31-08-2010 - 30-08-2013)