Dr Josephine Wu

Academic Fellow in Tissue Engineering & Regenerative Medicine

School of Engineering and Materials Science
Queen Mary University of London

josephine.wu@qmul.ac.uk

www.sems.qmul.ac.uk/staff/j.wu

Research
Publications
Grants

Research

cartilage, optogenetics, bioprinting

Underpinning Bioengineering, Musculoskeletal Models

Interests

Our research focus is on tissue engineering of cartilage and bone. In particular, we are interested in leveraging cellular self-assembly (spheroids) while applying bioengineering strategies (e.g. bioprinting, optogenetics) to define local identity and structure, leading to spatially organized tissues with enhanced functionality. Ultimately, these advanced human tissue models will help us to better understand joint disease, develop associated treatments, and accelerate the clinical translation of regenerative implants.

Publications

2023

Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signaling
Wu JY, Yeager K, Tavakol DN, Morsink M, Wang B, Soni RK, Hung CT, Vunjak-Novakovic G
Cell Reports, Elsevier Bv vol. 42 (5), 112509-112509.

DOI 10.1016/j.celrep.2023.112509

01-05-2023

2022

Bioengineering Human Cartilage–Bone Tissues for Modeling of Osteoarthritis
Wu JY, Vunjak-Novakovic G
Stem Cells and Development, Mary Ann Liebert Inc vol. 31 (15-16), 399-405.

DOI 10.1089/scd.2021.0317

01-08-2022

2020

Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regeneration
Chen D, Wu JY, Kennedy KM, Yeager K, Bernhard JC, Ng JJ, Zimmerman BK, Robinson S et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 12 (565)

DOI 10.1126/scitranslmed.abb6683

14-10-2020

2019

Long-Acting IL-33 Mobilizes High-Quality Hematopoietic Stem and Progenitor Cells More Efficiently Than Granulocyte Colony-Stimulating Factor or AMD3100
Alt C, Yuan S, Wu F, Stankovich B, Calaoagan J, Schopies S, Wu JY, Shen J et al.
Biology of Blood and Marrow Transplantation, Elsevier Bv vol. 25 (8), 1475-1485.

DOI 10.1016/j.bbmt.2019.05.030

01-08-2019

Grants

Engineering functional tissues by spatiotemporal patterning: 3D bioprinting and optogenetics for directing the organization of cell spheroid building blocks (OPTO-BIOPRINTING)
Josephine Wu
£685,186 Wellcome Trust
15-08-2025 - 14-08-2030