Dr Josephine Wu
Academic Fellow in Tissue Engineering & Regenerative Medicine
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
cartilage, optogenetics, bioprinting
Interests
Our research focus is on tissue engineering of cartilage and bone. In particular, we are interested in leveraging cellular self-assembly (spheroids) while applying bioengineering strategies (e.g. bioprinting, optogenetics) to define local identity and structure, leading to spatially organized tissues with enhanced functionality. Ultimately, these advanced human tissue models will help us to better understand joint disease, develop associated treatments, and accelerate the clinical translation of regenerative implants.Publications
2023
Directed differentiation of human iPSCs into mesenchymal lineages by optogenetic control of TGF-β signalingWu JY, Yeager K, Tavakol DN, Morsink M, Wang B, Soni RK, Hung CT, Vunjak-Novakovic G
Cell Reports, Elsevier vol. 42 (5)
01-05-2023
2022
Bioengineering Human Cartilage-Bone Tissues for Modeling of Osteoarthritis.Wu JY, Vunjak-Novakovic G
Stem Cells Dev vol. 31 (15-16), 399-405.
01-08-2022
2020
Tissue engineered autologous cartilage-bone grafts for temporomandibular joint regenerationChen D, Wu JY, Kennedy KM, Yeager K, Bernhard JC, Ng JJ, Zimmerman BK, Robinson S et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 12 (565)
14-10-2020
2019
Long-Acting IL-33 Mobilizes High-Quality Hematopoietic Stem and Progenitor Cells More Efficiently Than Granulocyte Colony-Stimulating Factor or AMD3100Alt C, Yuan S, Wu F, Stankovich B, Calaoagan J, Schopies S, Wu JY, Shen J et al.
Transplantation and Cellular Therapy, Elsevier vol. 25 (8), 1475-1485.
01-06-2019
Grants
Engineering functional tissues by spatiotemporal patterning: 3D bioprinting and optogenetics for directing the organization of cell spheroid building blocks (OPTO-BIOPRINTING)Josephine Wu
£685,186 Wellcome Trust
15-08-2025 - 14-08-2030