Prof Jane Sosabowski

Jane Sosabowski

Professor of Radionuclide Imaging and Therapy

Centre for Cancer Biomarkers and Biotherapeutics, Barts Cancer Institute
Queen Mary University of London
020 7882 3849
www.bci.qmul.ac.uk/staff/professor-jane-sosabowski/

Research

in vivo imaging, radiochemistry, radionuclide therapy, in vivo biodistribution

Interests

Interest in off-target toxicity excretory organs (e.g. kidney) of radiopharmaceutical therapies. Approach by NPL interested in radiobiology models

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Recommendations on the Clinical Application and Future Potential of α-Particle Therapy: A Comprehensive Review of the Results from the SECURE Project
Pharmaceuticals, Mdpi vol. 18 (10) 
18-10-2025
Minimising the impact of stable 208Pb on recovery of 212Pb from a generator
Roberts R, Carthy T, Young J, Awogboro T, Greenwood H, Sosabowski J, Heath S, Livens F
Ejnmmi Radiopharmacy and Chemistry, Springer Nature vol. 10 (1) 
30-07-2025
Development and characterisation of improved unifocal primary mouse lung cancer models with metastatic potential
Pedrosa A, Castillo‐Kauil A, Kravchuk Y, Reynolds L, Williams B, Moore D, Lang C, Allanki S et al.
The Journal of Pathology, Wiley vol. 266 (4-5), 405-420.  
18-06-2025
Cover Image, Volume 45, Issue 6
Mariniello K, Pittaway JFH, Altieri B, Borges KS, Hadjidemetriou I, Ribeiro C, Ruiz‐Babot G, Tourigny DS et al.
Cancer Communications, Wiley vol. 45 (6) 
01-06-2025
Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma
Mariniello K, Pittaway JFH, Altieri B, Borges KS, Hadjidemetriou I, Ribeiro C, Ruiz‐Babot G, Tourigny DS et al.
Cancer Communications, Wiley vol. 45 (6), 663-668.  
04-03-2025
Maleic anhydride derived diphosphines: adaptable chelators for receptor-targeted 99m Tc, 64 Cu and 188 Re radiotracers
Chemical Science, Royal Society of Chemistry (Rsc) vol. 16 (37), 17112-17126.  
01-01-2025

2024

Comparison of Two Chelator Scaffolds as Basis for Cholecystokinin-2 Receptor Targeting Bimodal Imaging Probes
Gariglio G, Bendova K, Hermann M, Olafsdottir A, Sosabowski JK, Petrik M, von Guggenberg E, Decristoforo C
Pharmaceuticals, Mdpi vol. 17 (12) 
22-11-2024
Receptor-Targeted Peptide Conjugates Based on Diphosphines Enable Preparation of 99mTc and 188Re Theranostic Agents for Prostate Cancer
Pham TT, Hungnes IN, Rivas C, Cleaver J, Firth G, Blower PJ, Sosabowski J, Cook GJR et al.
Journal of Nuclear Medicine, Society of Nuclear Medicine vol. 65 (7) 
06-06-2024
Selection of radionuclide(s) for targeted alpha therapy based on their nuclear decay properties
Ree SM, Greenwood H, Young JD, Roberts R, Livens FR, Heath SL, Sosabowski JK
Nuclear Medicine Communications, Wolters Kluwer vol. 45 (6), 465-473.  
11-03-2024

2023

Radionuclides for Health UK: improving UK access to radionuclides for molecular radiotherapy
Young JD, Tinsley TP, Blower PJ, Sosabowski JK
In Environmental Radiochemical Analysis Vii, Royal Society of Chemistry (Rsc) 58-68.  
08-12-2023
32 Gene Editing/Gene Therapies: NO MORE SHOTS IN THE DARK: MODELING CAR T CELL TRAFFICKING
Blanco EB, Kasahni R, Cleaver J, Foster J, Sosabowski J, Papa S
Cytotherapy, Elsevier vol. 25 (6), s24-s25.  
01-05-2023
Spatiotemporal tracking of gold nanorods after intranasal administration for brain targeting
Han S, Wang JT-W, Yavuz E, Zam A, Rouatbi N, Utami RN, Liam-Or R, Griffiths A et al.
Journal of Controlled Release, Elsevier vol. 357, 606-619.  
23-04-2023
NO MORE SHOTS IN THE DARK: MODELING CAR T CELL TRAFFICKING
Blanco EB, Kasahni R, Cleaver J, Foster J, Sosabowski J, Papa S
 
01-01-2023

2022

MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis
Pistorius K, Ly L, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J et al.
Ebiomedicine, Elsevier vol. 79 
14-04-2022
Preclinical PET and SPECT Instrumentation
Dexter K, Foster J, Sosabowski J, Petrik M
In Nuclear Medicine and Molecular Imaging, Elsevier 473-484.  
01-01-2022
Preclinical PET and SPECT imaging
Dexter K, Foster J, Petrik M, Sosabowski J
In Nuclear Medicine and Molecular Imaging, Elsevier 662-670.  
01-01-2022
Optimisation of αvβ6-specific peptides for use in targeted radionuclide therapy
Kashani R, Khan N, Foster J, Young J, Marshall J, Sosabowski JK
 
01-01-2022
MCTR3 reprogramming arthritic monocytes to exert pro-resolving and tissue-protective functions in inflammatory arthritis
Pistorius K, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J, Hopkinson M et al.
 
01-01-2022

2021

New Bioconjugated Technetium and Rhenium Folates Synthesized by Transmetallation Reaction with Zinc Derivatives
Borràs J, Foster J, Kashani R, Meléndez-Alafort L, Sosabowski J, Suades J, Barnadas-Rodríguez R
Molecules, Mdpi vol. 26 (8) 
19-04-2021
Bioconjugated technetium carbonyls by transmetalation reaction with zinc derivatives
Borràs J, Lecina J, Foster J, Kashani R, Melendez-Alafort L, Sosabowski J, Suades J
Bioorganic & Medicinal Chemistry Letters, Elsevier vol. 37 
05-02-2021

2020

MRI-based machine learning for detection of orthotopic pancreatic cancer in KPC mice
Brook J, Macholl S, Candido J, Arkell R, Greenblatt E, Hesterman J, Sosabowski J
Pancreatology, Elsevier vol. 20 (8) 
01-12-2020
Simultaneous dual isotope PET-SPECT/CT imaging of pancreatic cancer
Dexter K, BROWN N, Foster J, Kashani R, CHUPIN J, Cleaver J, Cutmore L, Marshall J et al.
 
26-08-2020
Cancer associated fibroblast FAK regulates malignant cell metabolism.
Demircioglu F, Wang J, Candido J, Costa ASH, Casado P, de Luxan Delgado B, Reynolds LE, Gomez-Escudero J et al.
Nature Communications, Nature Research (Part of Springer Nature) vol. 11 (1), 1290-1290.  
10-03-2020
Organ Biodistribution of Radiolabelled δγ T Cells Following Liposomal Alendronate Administration in Different Mice Tumour Models
Wang JT-W, Hodgins NO, Al-Jamal WT, Maher J, Sosabowski JK, Al-Jamal KT
Nanotheranostics, Ivyspring International Publisher vol. 4 (2), 71-82.  
06-02-2020
18F-Trifluoromethanesulfinate Enables Direct C–H 18F-Trifluoromethylation of Native Aromatic Residues in Peptides
Kee CW, Tack O, Guibbal F, Wilson TC, Isenegger PG, Imiołek M, Verhoog S, Tilby M et al.
Journal of The American Chemical Society, American Chemical Society vol. 142 (3), 1180-1185.  
22-01-2020

2019

Neutron Activated 153Sm Sealed in Carbon Nanocapsules for in Vivo Imaging and Tumor Radiotherapy
Wang JT-W, Klippstein R, Martincic M, Pach E, Feldman R, Šefl M, Michel Y, Asker D et al.
Acs Nano, American Chemical Society (Acs) vol. 14 (1), 129-141.  
19-11-2019
Functionalised LRP1 targeted carbon nanotubes across the blood-brain barrier in vitro and in vivo after intravenous injection
Wang J, Kafa H, Rubio N, Bansal S, Festy F, Sosabowski J, Abbott J, Al-Jamal K
 
12-10-2019
Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer
Stella Man YK, Foster J, Carapuça E, Davies JA, Parker AL, Sosabowski J, Halldén G
Scientific Reports, Springer Nature vol. 9 (1) 
06-09-2019
AGR2, a unique tumor-associated antigen, is a promising candidate for antibody targeting
Crnogorac-Jurcevic T, Radon T, Shah S, Weeks M, Foster J, Sosabowski J, Dumartin L
Oncotarget, Impact Journals 
02-07-2019
Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting: Erratum
Klingler M, Decristoforo C, Rangger C, Summer D, Foster J, Sosabowski JK, von Guggenberg E
Theranostics, Ivyspring International Publisher vol. 9 (16), 4595-4596.  
19-06-2019
New Developments in Imaging Cell-Based Therapy
Martinez O, Sosabowski J, Maher J, Papa S
Journal of Nuclear Medicine, Society of Nuclear Medicine vol. 60 (6), 730-735.  
12-04-2019
Rational Design, Synthesis and Preliminary Evaluation of Novel Fusarinine C-Based Chelators for Radiolabeling with Zirconium-89
Zhai C, He S, Ye Y, Rangger C, Kaeopookum P, Summer D, Haas H, Kremser L et al.
Biomolecules, Mdpi vol. 9 (3) 
06-03-2019
Membrane Radiolabelling of Exosomes for Comparative Biodistribution Analysis in Immunocompetent and Immunodeficient Mice - A Novel and Universal Approach
Faruqu FN, Wang JT-W, Xu L, McNickle L, Chong EM-Y, Walters A, Gurney M, Clayton A et al.
Theranostics, Ivyspring International Publisher vol. 9 (6), 1666-1682.  
28-02-2019
Synthesis and comparison of novel fusarinine C-based chelators for 89Zr-labeling
Zhai C, He S, Chen X, Lu J, Rangger C, Summer D, Haas H, Foster J et al.
 
01-01-2019

2018

DOTA-MGS5, a New Cholecystokinin-2 Receptor-Targeting Peptide Analog with an Optimized Targeting Profile for Theranostic Use
Klingler M, Summer D, Rangger C, Haubner R, Foster J, Sosabowski J, Decristoforo C, Virgolini I et al.
Journal of Nuclear Medicine, Society of Nuclear Medicine vol. 60 (7), 1010-1016.  
07-12-2018
P1.03-19 Antibody Blockade of Integrin Alpha-V-Beta-6 (avb6) as a Novel Treatment for NSCLC
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J
 
01-10-2018
Radiolabeled Antibodies Against Müllerian-Inhibiting Substance Receptor, Type II: New Tools for a Theranostic Approach in Ovarian Cancer
Deshayes E, Ladjohounlou R, Le Fur P, Pichard A, Lozza C, Boudousq V, Sevestre S, Jarlier M et al.
Journal of Nuclear Medicine, Society of Nuclear Medicine vol. 59 (8), 1234-1242.  
19-04-2018
Site-specific stabilization of minigastrin analogs against enzymatic degradation for enhanced cholecystokinin-2 receptor targeting.
Klingler M, Decristoforo C, Rangger C, Summer D, Foster J, Sosabowski JK, von Guggenberg E
Theranostics vol. 8 (11), 2896-2908.  
16-04-2018
Clinically compliant spatial and temporal imaging of chimeric antigen receptor T-cells.
Emami-Shahri N, Foster J, Kashani R, Gazinska P, Cook C, Sosabowski J, Maher J, Papa S
Nature Communications, Nature Publishing Group vol. 9 (1), 1081-1081.  
14-03-2018
Functionalised Carbon Nanotubes Enhance Brain Delivery of Amyloid-Targeting Pittsburgh Compound B (PiB)-Derived Ligands
Costa PM, Wang JT-W, Morfin J-F, Khanum T, To W, Sosabowski J, Tóth E, Al-Jamal KT
Nanotheranostics, Ivyspring International Publisher vol. 2 (2), 168-183.  
15-02-2018
Anesthesia and Monitoring of Animals During MRI Studies
Tremoleda JL, Macholl S, Sosabowski JK
In Preclinical Mri, Springer Nature 423-439.  
01-01-2018
Blockade of integrin alpha-v-beta-6 (αvβ6) reduces the invasive potential of NSCLC
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J
 
01-01-2018
Theranostic approach in ovarian cancer using Anti-MISRII radiolabeled antibodies
Pouget J, Deshayes E, Ladjohounlou R, le Fur P, Pichard A, Lozza C, Kashani R, Koch J et al.
 
01-01-2018
12 Blockade of integrin alpha-v-beta-6 (αvβ6) reduces the invasive potential of NSCLC
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J
Lung Cancer, Elsevier vol. 115, s5-s6.  
01-01-2018

2017

Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy
Hodgins NO, Al-Jamal WT, Wang JT-W, Klippstein R, Costa PM, Sosabowski JK, Marshall JF, Maher J et al.
Journal of Controlled Release, Elsevier vol. 256, 141-152.  
18-04-2017
High-throughput high-volume nuclear imaging for preclinical in vivo compound screening§.
Macholl S, Finucane CM, Hesterman J, Mather SJ, Pauplis R, Scully D, Sosabowski JK, Jouannot E
Ejnmmi Res, Springer Open vol. 7 (1), 33-33.  
07-04-2017
Development of non-invasive imaging of integrin alpha-v-beta-6 (alpha v beta 6)-positive lung cancers in advance of testing alpha v beta 6-targeted therapies
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J
British Thoracic Oncology Group Conference 2017 Dublin, Ireland 25 Jan 2017 - 27 Jan 2017. 
31-01-2017
Novel Hyaluronic Acid Conjugates for Dual Nuclear Imaging and Therapy in CD44-Expressing Tumors in Mice In Vivo
Dubey RD, Klippstein R, Wang JT-W, Hodgins N, Mei K-C, Sosabowski J, Hider RC, Abbate V et al.
Nanotheranostics, Ivyspring International Publisher vol. 1 (1), 59-79.  
01-01-2017
Evaluation of the physicochemical properties of 99mTechnetium-Exametazime (Medi-Exametazime™) and its biodistribution in a pre-clinical mouse model
Ahmed W, Barker SA, Sosabowski J, Foster JM, Soanes R, Hartman N
 
01-01-2017
New radiolabelled minigastrin analogues with improved CCK2R targeting for diagnostic and therapeutic use
Klingler M, Rangger C, Summer D, Foster J, Sosabowski JK, von Guggenberg E
 
01-01-2017
Stability assessment after reconstitution and investigation of the biodistribution in a pre-clinical mouse model of 99mTechnetium-Sestamibi (Cardiovis™)
Mak C, Barker SA, Sosabowski JK, Foster JM, Hartman NG
 
01-01-2017
6: Development of non-invasive imaging of integrin alpha-v-beta-6 (αvβ6)-positive lung cancers in advance of testing αvβ6-targeted therapies
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J
Lung Cancer, Elsevier vol. 103 
01-01-2017

2016

Engineering hepatitis B virus core particles for targeting HER2 receptors in vitro and in vivo.
Mohamed Suffian IFB, Wang JT-W, Hodgins NO, Klippstein R, Garcia-Maya M, Brown P, Nishimura Y, Heidari H et al.
Biomaterials, Elsevier vol. 120, 126-138.  
14-12-2016
Pre-clinical quantitative imaging and mouse-specific dosimetry for 111In-labelled radiotracers
Denis-Bacelar AM, Cronin SE, Da Pieve C, Paul RL, Eccles SA, Spinks TJ, Box C, Hall A et al.
Ejnmmi Research, Springer Nature vol. 6 (1) 
25-11-2016
Magnetic Drug Targeting: Preclinical in Vivo Studies, Mathematical Modeling, and Extrapolation to Humans
Al-Jamal KT, Bai J, Wang JT-W, Protti A, Southern P, Bogart L, Heidari H, Li X et al.
Nano Letters: a Journal Dedicated to Nanoscience and Nanotechnology, American Chemical Society 
19-08-2016
Abstract 2315: Dynamic SPECT imaging of PSMA-specific CAR T cells in mice bearing prostate cancer
Emami-Shahri N, Foster J, Sosabowski J, Maher J, Papa S
 
15-07-2016
Localized Irradiation of Cell Membrane by Auger Electrons Is Cytotoxic Through Oxidative Stress-Mediated Nontargeted Effects
Paillas S, Ladjohounlou R, Lozza C, Pichard A, Boudousq V, Jarlier M, Sevestre S, Le Blay M et al.
Antioxidants and Redox Signaling, Mary Ann Liebert vol. 25 (8) 
05-07-2016
18th European Symposium on Radiopharmacy and Radiopharmaceuticals
Radchenko V, Engle JW, Roy C, Griswold J, Nortier MF, Birnbaum ER, Brugh M, Mirzadeh S et al.
Ejnmmi Radiopharmacy and Chemistry, Springer Nature vol. 1 (Suppl 1) 
01-06-2016
In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J et al.
European Journal of Nuclear Medicine and Molecular Imaging 
07-05-2016
The Shortening of MWNT-SPION Hybrids by Steam Treatment Improves Their Magnetic Resonance Imaging Properties In Vitro and In Vivo
Cabana L, Bourgognon M, Wang JT-W, Protti A, Klippstein R, de Rosales RTM, Shah AM, Fontcuberta J et al.
Small, Wiley: 12 Months vol. 12 (21), 2893-2905.  
15-04-2016
Translocation of LRP1 targeted carbon nanotubes of different diameters across the blood–brain barrier in vitro and in vivo
Kafa H, Wang JT-W, Rubio N, Klippstein R, Costa PM, Hassan HAFM, Sosabowski JK, Bansal SS et al.
Journal of Controlled Release, Elsevier vol. 225, 217-229.  
23-01-2016
Triple-Modal Imaging of Magnetically-Targeted Nanocapsules in Solid TumoursIn Vivo
Bai J, Wang JT-W, Rubio N, Protti A, Heidari H, Elgogary R, Southern P, Al-Jamal WT et al.
Theranostics, Ivyspring International Publisher vol. 6 (3), 342-356.  
01-01-2016
SPECT Characterisation and Quantification of Preclinical Scanners
Spinks TJ, Flux G, Sosabowski J, Finucane C, Macholl S
 
01-01-2016
Localized irradiation of cell membrane by Auger electrons is cytotoxic through non-targeted effects involving p38 and JNK signaling pathways
Paillas S, Ladjohounlou R, Lozza C, Pichard A, Boudousq V, Jarlier M, Deshayes E, Sosabowski J et al.
 
01-01-2016
The effect of partial volume in quantitative pre-clinical imaging of 111In-labelled antibodies
Denis-Bacelar AM, Cronin SE, Da Pieve C, Paul R, Eccles SA, Spinks T, Box C, Hall A et al.
 
01-01-2016

2015

Kinetics of functionalised carbon nanotube distribution in mouse brain after systemic injection: Spatial to ultra-structural analyses
Wang JT-W, Rubio N, Kafa H, Venturelli E, Fabbro C, Ménard-Moyon C, Da Ros T, Sosabowski JK et al.
Journal of Controlled Release, Elsevier vol. 224, 22-32.  
30-12-2015
T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION.
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al.
Shock vol. 44 Suppl 2, 24-25.  
01-10-2015
Correction: Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha
Staff TPO
Plos One, Public Library of Science (Plos) vol. 10 (4) 
10-04-2015
Imaging technologies and basic considerations for welfare of laboratory rodents
Tremoleda JL, Sosabowski J
Lab Animal, Springer Nature vol. 44 (3), 97-105.  
17-02-2015
Pharmacokinetic Characteristics, Pharmacodynamic Effect and In Vivo Antiviral Efficacy of Liver-Targeted Interferon Alpha
Rycroft D, Sosabowski J, Coulstock E, Davies M, Morrey J, Friel S, Kelly F, Hamatake R et al.
Plos One, Public Library of Science (Plos) vol. 10 (2) 
17-02-2015
Development of the designed ankyrin repeat protein (DARPin) G3 for HER2 molecular imaging.
Goldstein R, Sosabowski J, Livanos M, Leyton J, Vigor K, Bhavsar G, Nagy-Davidescu G, Rashid M et al.
Eur J Nucl Med Mol Imaging vol. 42 (2), 288-301.  
01-02-2015
Imaging technologies and basic considerations for welfare of laboratory rodents
Tremoleda JL, Sosabowski J
Lab Animal vol. 44 (3), 101-109.  
01-01-2015
Targeted Radionuclide Therapy using high-LET particle emitter-labeled vectors against alpha-v-beta6-expressing cancers
Paillas S, Desai A, Quetier I, Marshall J, Pouget J, Sosabowski J
 
01-01-2015
IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION
Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ et al.
 
01-01-2015

2014

Adoptive immunotherapy of epithelial ovarian cancer with Vγ9Vδ2 T cells, potentiated by liposomal alendronic acid.
Parente-Pereira AC, Shmeeda H, Whilding LM, Zambirinis CP, Foster J, van der Stegen SJC, Beatson R, Zabinski T et al.
J Immunol vol. 193 (11), 5557-5566.  
01-12-2014
Evaluation and comparison of a new DOTA and DTPA-bombesin agonist in vitro and in vivo in low and high GRPR expressing prostate and breast tumor models
Pujatti PB, Foster JM, Finucane C, Hudson CD, Burnet JC, Pasqualoto KFM, Mengatti J, Mather SJ et al.
Applied Radiation and Isotopes, Elsevier vol. 96, 91-101.  
11-11-2014
PET and SPECT imaging of a radiolabeled minigastrin analogue conjugated with DOTA, NOTA, and NODAGA and labeled with (64)Cu, (68)Ga, and (111)In.
Roosenburg S, Laverman P, Joosten L, Cooper MS, Kolenc-Peitl PK, Foster JM, Hudson C, Leyton J et al.
Mol Pharm vol. 11 (11), 3930-3937.  
03-11-2014
The relationship between the diameter of chemically-functionalized multi-walled carbon nanotubes and their organ biodistribution profiles in vivo.
Wang JT-W, Fabbro C, Venturelli E, Ménard-Moyon C, Chaloin O, Da Ros T, Methven L, Nunes A et al.
Biomaterials vol. 35 (35), 9517-9528.  
01-11-2014
Magnetically decorated multiwalled carbon nanotubes as dual mri and spect contrast agents
Wang JTW, Cabana L, Bourgognon M, Kafa H, Protti A, Venner K, Shah AM, Sosabowski JK et al.
Advanced Functional Materials vol. 24 (13), 1880-1894.  
02-04-2014
Contrast Agents: Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents (Adv. Funct. Mater. 13/2014)
Wang JT, Cabana L, Bourgognon M, Kafa H, Protti A, Venner K, Shah AM, Sosabowski JK et al.
Advanced Functional Materials, Wiley vol. 24 (13), 1879-1879.  
01-04-2014
Prognostic and therapeutic impact of argininosuccinate synthetase 1 control in bladder cancer as monitored longitudinally by PET imaging.
Allen MD, Luong P, Hudson C, Leyton J, Delage B, Ghazaly E, Cutts R, Yuan M et al.
Cancer Res vol. 74 (3), 896-907.  
01-02-2014
Pre-clinical image-based dosimetry using HER2 targeting In-111 labelled antibodies
Da Pieve C, Cronin SE, Paul RL, Denis-Bacelar AM, Frisch KJ, Hall A, Sosabowski JK, Spinks T et al.
 
01-01-2014

2013

Preclinical in vivo modeling of cytokine release syndrome induced by ErbB-retargeted human T cells: identifying a window of therapeutic opportunity?
van der Stegen SJC, Davies DM, Wilkie S, Foster J, Sosabowski JK, Burnet J, Whilding LM, Petrovic RM et al.
J Immunol vol. 191 (9), 4589-4598.  
01-11-2013
Developments in single photon emission computed tomography and PET-based HER2 molecular imaging for breast cancer.
Goldstein R, Sosabowski J, Vigor K, Chester K, Meyer T
Expert Rev Anticancer Ther vol. 13 (3), 359-373.  
01-03-2013
Liver-targeting of interferon-alpha with tissue-specific domain antibodies.
Coulstock E, Sosabowski J, Ovečka M, Prince R, Goodall L, Mudd C, Sepp A, Davies M et al.
Plos One vol. 8 (2) 
01-01-2013
Magnetically Decorated Multiwalled Carbon Nanotubes as Dual MRI and SPECT Contrast Agents
Wang JT-W, Cabana L, Bourgognon M, Kafa H, Protti A, Venner K, Shah AM, Sosabowski JK et al.
Advanced Functional Materials 
01-01-2013
Tumor targeting and imaging with dual-peptide conjugated multifunctional liposomal nanoparticles.
Rangger C, Helbok A, Sosabowski J, Kremser C, Koehler G, Prassl R, Andreae F, Virgolini IJ et al.
Int J Nanomedicine vol. 8, 4659-4671.  
01-01-2013
Pre-clinical developments of the G3 Designed ankyrin repeat protein (DARPin) for invivo assessment of HERZ expression
Goldstein R, Tolner B, Leyton J, Livanos M, Bhavsar G, Vigor K, Nagy G, Mather S et al.
 
01-01-2013

2012

Preclinical evaluation of radiolabeled DOTA-derivatized cyclic minigastrin analogs for targeting cholecystokinin receptor expressing malignancies.
von Guggenberg E, Rangger C, Sosabowski J, Laverman P, Reubi J-C, Virgolini IJ, Decristoforo C
Mol Imaging Biol vol. 14 (3), 366-375.  
01-06-2012
Radiolabelled peptides for oncological diagnosis.
Laverman P, Sosabowski JK, Boerman OC, Oyen WJG
Eur J Nucl Med Mol Imaging vol. 39 Suppl 1 (Suppl 1), S78-S92.  
01-02-2012
PET and SPECT Imaging of a CCK2 Receptor-Binding Peptide Comparing Various Chelators and Radionuclides
Joosten L, Sosabowski JK, Cooper MS, Foster J, Burnet J, Oyen WJG, Boerman OC, Blower PJ et al.
 
01-01-2012
Influence of PEGylation and RGD loading on the targeting properties of radiolabeled liposomal nanoparticles.
Rangger C, Helbok A, von Guggenberg E, Sosabowski J, Radolf T, Prassl R, Andreae F, Thurner GC et al.
Int J Nanomedicine vol. 7, 5889-5900.  
01-01-2012

2011

Comparative biodistribution of 12 ¹¹¹In-labelled gastrin/CCK2 receptor-targeting peptides.
Laverman P, Joosten L, Eek A, Roosenburg S, Peitl PK, Maina T, Mäcke H, Aloj L et al.
Eur J Nucl Med Mol Imaging vol. 38 (8), 1410-1416.  
01-08-2011
Comparison of the binding and internalization properties of 12 DOTA-coupled and ¹¹¹In-labelled CCK2/gastrin receptor binding peptides: a collaborative project under COST Action BM0607.
Aloj L, Aurilio M, Rinaldi V, D'ambrosio L, Tesauro D, Peitl PK, Maina T, Mansi R et al.
Eur J Nucl Med Mol Imaging vol. 38 (8), 1417-1425.  
01-08-2011
Comparison of biological stability and metabolism of CCK2 receptor targeting peptides, a collaborative project under COST BM0607.
Ocak M, Helbok A, Rangger C, Peitl PK, Nock BA, Morelli G, Eek A, Sosabowski JK et al.
Eur J Nucl Med Mol Imaging vol. 38 (8), 1426-1435.  
01-08-2011
Quantitative Accuracy of Low-Count SPECT Imaging in Phantom and In Vivo Mouse Studies.
Finucane CM, Murray I, Sosabowski JK, Foster JM, Mather SJ
Int J Mol Imaging vol. 2011 
01-01-2011
Biodistribution and microSPECT/CT imaging of 111In-radiolabelled dual targeted domain antibodies
Sosabowski J, Coulstock E, Walker A, Sepp A, Kashani R, Foster J, Burnet J, Prince R et al.
 
01-01-2011
Comparative small animal SPECT/CT imaging of twelve 111In-labelled CCK2-receptor targeting peptides
Sosabowski J, Finucane C, Foster J, Ellison D, Burnet J, Laverman P, Mather S
 
01-01-2011
Radiopeptide internalisation and externalization assays: cell viability and radioligand integrity.
Naqvi SAR, Sosabowski JK, Nagra SA, Ishfaq MM, Mather SJ, Matzow T
Appl Radiat Isot vol. 69 (1), 68-74.  
01-01-2011

2010

Comparison Of 111-In Labelled CCK2-Receptor Targeting Peptides Using Nanospect/CT Imaging, A Collaborative Project Under COST BM0607
Sosabowski J, Finucane C, Foster J, Ellison D, Burnet J, Mather S
 
01-10-2010
Insertion of a lysosomal enzyme cleavage site into the sequence of a radiolabeled neuropeptide influences cell trafficking in vitro and in vivo.
Naqvi SAR, Matzow T, Finucane C, Nagra SA, Ishfaq MM, Mather SJ, Sosabowski J
Cancer Biother Radiopharm vol. 25 (1), 89-95.  
01-02-2010

2009

Targeting of CCK-2 receptor-expressing tumors using a radiolabeled divalent gastrin peptide.
Sosabowski JK, Matzow T, Foster JM, Finucane C, Ellison D, Watson SA, Mather SJ
J Nucl Med vol. 50 (12), 2082-2089.  
01-12-2009
TARGETING OF CCK2 RECEPTOR EXPRESSING TUMOURS USING AN 111IN-LABELLED MINIGASTRIN DIMER
Sosabowski J, Matzow T, Foster J, Mather S
J Labelled Compd Rad vol. 52, S327-S327.  
01-01-2009

2007

Formulation development and manufacturing of a gastrin/CCK-2 receptor targeting peptide as an intermediate drug product for a clinical imaging study.
Sosabowski JK, Lee M, Dekker BA, Simmons BP, Singh S, Beresford H, Hagan SA, McKenzie AJ et al.
Eur J Pharm Sci vol. 31 (2), 102-111.  
01-06-2007
Selection of radiolabeled gastrin analogs for peptide receptor-targeted radionuclide therapy.
Mather SJ, McKenzie AJ, Sosabowski JK, Morris TM, Ellison D, Watson SA
J Nucl Med vol. 48 (4), 615-622.  
01-04-2007

2006

Conjugation of DOTA-like chelating agents to peptides and radiolabeling with trivalent metallic isotopes.
Sosabowski JK, Mather SJ
Nat Protoc vol. 1 (2), 972-976.  
01-01-2006

2005

Radiopharmacy - Overcoming the training barriers
Sosabowski J, Mather SJ
Hospital Pharmacist vol. 12 (8), 311-313.  
01-09-2005
SYNTHESIS OF DICARBA ANALOGUES OF OCTREOTIDE USING TANDEM HOMOGENEOUS CATALYSIS
Whelan AN, Elaridi J, Smith SV, Mulder RJ, Robinson AJ, Sosabowski J
J Labelled Compd Rad vol. 48, S238-S238.  
01-06-2005
P27 DEVELOPMENT OF ‘THE RADIOPHARMACIST'S FRIEND’
Murray IS, Cooper MS, Sosabowski JK
Nuclear Medicine Communications, Wolters Kluwer vol. 26 (3) 
01-03-2005

2004

VIRRAD, The virtual radiopharmacy: the first prototype
Mather SJ, Sosabowski JK
Nuclear Medicine Communications, Wolters Kluwer vol. 25 (4) 
01-04-2004

2003

Radiolabelling of peptides for diagnosis and therapy of non-oncological diseases
Sosabowski J, Melendez-Alafort L, Mather S
Q J Nucl Med vol. 47 (4), 223-237.  
01-12-2003
Absence of pituitary adenylate cyclase-activating polypeptide-stimulated transcription of the human glycoprotein alpha-subunit gene in LbetaT2 gonadotrophs reveals disrupted cAMP-mediated gene transcription.
Fowkes RC, Sidhu KK, Sosabowski JK, King P, Burrin JM
J Mol Endocrinol vol. 31 (2), 263-278.  
01-10-2003

2001

Preparation of an I‐124 labelled doxorubicin conjugate for in vivo assessment of polymer targeted anticancer therapy
Hadfield JA, Pietrzynski G, Bailey J, Alakhov V, Sosabowski JK, Zweit J, Ranson M
Journal of Labelled Compounds and Radiopharmaceuticals, Wiley vol. 44 (S1), s370-s371.  
01-05-2001

2000

99mTc-HYNIC-[Tyr3]-octreotide for imaging somatostatin-receptor-positive tumors: preclinical evaluation and comparison with 111In-octreotide.
Decristoforo C, Melendez-Alafort L, Sosabowski JK, Mather SJ
Journal of Nuclear Medicine vol. 41 (6), 1114-1119.  
01-06-2000
Copper bis(diphosphine) complexes: radiopharmaceuticals for the detection of multi-drug resistance in tumours by PET
Lewis JS, Dearling JLJ, Sosabowski JK, Zweit J, Carnochan P, Kelland LR, Coley HM, Blower PJ
European Journal of Nuclear Medicine and Molecular Imaging, Springer Nature vol. 27 (6), 638-646.  
01-05-2000

1999

Metal complexes of bleomycin: evaluation of [Rh-105]-bleomycin for use in targeted radiotherapy
Brooks RC, Carnochan P, Vollano JF, Powell NA, Zweit J, Sosabowski JK, Martellucci S, Darkes MC et al.
Nuclear Medicine and Biology, Elsevier vol. 26 (4), 421-430.  
01-05-1999

Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinoma
Mariniello K, Pittaway JFH, Altieri B, Borges KS, Hadjidemetriou I, Ribeiro C, Ruiz-Babot G, Lim JA et al.
In Biorxiv 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconWhole genome CRISPR screens to map genetic determinants of radionuclide therapy of cancer
Jane Sosabowski
£40,000 ARTBIO LIMITED
01-09-2024 - 31-08-2028
bullet iconImproved Characterisation Of Disease Models For Validation Of Quantative PET And SPECT In Vivo Imaging
Jane Sosabowski
£437,134 INVICRO LLC
17-09-2022 - 26-05-2026
bullet iconDevelopment of a Gallium-68 PET Clinical Imaging Service
Jane Sosabowski
£549,991 Barts and the London Charity
01-04-2022 - 12-01-2026
bullet iconDinutuximab Beta for molecular imaging and radiotherapy of high-risk neuroblastoma
Jane Sosabowski
£30,000 Neuroblastoma UK
01-04-2022 - 20-11-2025

bullet iconMRIP Programme Cyclife Aquila Lead-212 hot cell
Jane Sosabowski
£49,979 Cyclife Aquila Nuclear
30-11-2023 - 31-03-2025
bullet iconMedical Radionuclide Innovation Programme - MRIP To Establish the First UK Production of the Alpha-Particle Emitting Radionuclide at Queen Mary University of London for the Development of UK Astatine-211 Production
Jane Sosabowski
£268,399 Department for Energy Security & Net Zero
13-11-2023 - 31-03-2025
bullet iconMulti-user micro PET/CT equipment for biomedical research
Jane Sosabowski, Julie Foster and John Marshall
£475,110 MRC Medical Research Council
01-07-2023 - 29-02-2024
bullet iconGamma delta T-cell immunotherapy in osteosarcoma II
Jane Sosabowski
£28,467 Little Princess Trust
01-09-2022 - 31-10-2024
bullet iconTargeted molecular radiotherapy of αvβ6 expressing head and neck cancer
Jane Sosabowski
£25,000 CR-UK Cancer Research UK
01-06-2022 - 31-12-2023
bullet iconGuided gamma-deltas for osteosarcoma immunotherapy
Jane Sosabowski
£9,170 CR-UK Cancer Research UK
01-04-2022 - 31-03-2023
bullet iconSupporting homing and longevity of gamma delta T-cells for cancer immunotherapy
Jane Sosabowski
£17,727 Academy of Medical Sciences
01-04-2022 - 31-03-2024
bullet iconUK supply of radionuclides for molecular radiotherapy
Jane Sosabowski
£3,600 CR-UK Cancer Research UK
01-11-2021 - 31-10-2022
bullet iconTheragnostic radiopharmaceuticals for the imaging and treatment of childhood neuroblastoma
Jane Sosabowski
£12,500 CR-UK Cancer Research UK
01-05-2021 - 30-04-2022
bullet iconPANORAMA Study
Prabhakar Rajan and Jane Sosabowski
Barts and the London Charity
01-01-2020 - 31-12-2020
bullet iconImplementation of a 3D Computational Mouse Atlas for Detection of Pancreatic Tumours in Transgenic Mice
Jane Sosabowski
£98,713 NC3Rs National Centre for the Replacement, Refinement and Reduction of Animals in Research
01-10-2019 - 31-03-2021
bullet iconCiCinAT: PET tracking of cell therapies
Jane Sosabowski
£13,063 King's College London (KCL)
01-07-2019 - 13-10-2021
bullet iconOptimizing CAR T efficacy through the WNK1 pathway
Jane Sosabowski
£10,577 King's College London (KCL)
01-06-2019 - 31-08-2020
bullet iconImproved characterisation of disease models for validation of quantative PET and SPECT in vivo imaging
Jane Sosabowski
£331,952 INVICRO LLC
01-04-2018 - 16-09-2022
bullet iconRadiolabelling and in vitro evaluation of biotherapeutics
Jane Sosabowski
£24,480 INVICRO LLC
15-01-2018 - 14-01-2019
bullet iconDevelopment of a 3D mouse atlas tool for improved non-invasive imaging of orthoptopic mouse models of pancreatic cancer
Jane Sosabowski
£90,000 MRC Medical Research Council
05-10-2015 - 30-09-2018
bullet iconDevelopment of nuclear and optical imaging techniques to characterise the distribution kinetics of therapeutic macromoleuler in disease
Jane Sosabowski
£31,998 GSK GlaxoSmithKline UK Ltd
01-10-2014 - 30-09-2018