Dr Jianmin Chen
Postdoctoral Researcher
Research
Interests
I am interested to study the switching of phenotypes and alterations in phagocytosis activity of macrophages upon pharmaceutical treatments in vitro. Biogel-elicited macrophages or bone marrow-derived macrophages are cultured. Phenotypes and phagocytosis activity of macrophages are determined by flow cytometry.Publications
Publications of specific relevance to Predictive in vitro Models2021
Chen J, Norling LV, Mesa JG, de Paula Silva M, Burton SE, Reutelingsperger C, Perretti M and Cooper D (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of The National Academy of Sciences of The United States of America vol. 118, (38) 10.1073/pnas.2020385118De Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M, Gaffney A, Brennan E, Kantharidis P, Cooper ME, Leroy X, Perretti M, Gilroy D, Godson C and Guiry PJ (2021). Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A2020
Chen J, Purvis GSD, Collotta D, Zoubi SA, Sugimoto MA, Cacace A, Martin L, Colas RA, Collino M, Dalli J and Thiemermann C (2020). RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance. Frontiers Media Frontiers in Immunology vol. 11, 2080-2080. 10.3389/fimmu.2020.020802019
de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C and Guiry PJ (2019). Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A2018
Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C and Ahluwalia A (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. Faseb J fj201701303-fj201701303. 10.1096/fj.201701303RKhan AI, Kapoor A, Chen J, Martin L, Rogazzo M, Mercier T, Decosterd L, Collino M and Thiemermann C (2018). The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction. Shock vol. 49, (6) 675-681. 10.1097/SHK.00000000000009632017
Purvis GSD, Chiazza F, Chen J, Loiola RA, Martin L, Fountoulakis N, Gnudi L, Collino M, Thiemermann C and Solito E (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Springer Verlag Diabetologia 10.1007/s00125-017-4469-yJohnson FL, Patel NSA, Purvis GSD, Chiazza F, Chen J, Sordi R, Hache G, Merezhko VV, Collino M, Yaqoob MM and Thiemermann C (2017). Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis. J Am Heart Assoc vol. 6, (7) 10.1161/JAHA.116.005092Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M, Thiemermann C and Schuerholz T (2017). The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers Media Front Immunol vol. 8, 681-681. 10.3389/fimmu.2017.006812016
Chen J and Thiemermann C (2016). Selenium and niacin for sepsis therapy: The sum is greater than its parts. Critical Care Medicine vol. 44, (6) 1256-1257. 10.1097/CCM.0000000000001493Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N, Perretti M, Hobbs A, Collino M, Yaqoob M and THIEMERMANN C (2016). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. American Society of Nephrology Journal of The American Society of Nephrology 10.1681/ASN.20150606702014
Gobbetti T, Coldewey SM, Chen J, McArthur S, Le Faouder P, Cenac N, Flower RJ, Thiemermann C and Perretti M (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of The National Academy of Sciences of The United States of America vol. 111, (52) 18685-18690. 10.1073/pnas.1410938111Chen J, Chiazza F, Collino M, Patel NSA, Coldewey SM and Thiemermann C (2014). Gender dimorphism of the cardiac dysfunction in murine sepsis: Signalling mechanisms and age-dependency. Plos One vol. 9, (6) 10.1371/journal.pone.0100631Grants
Cardiomyopathy in RAPerretti M, Norling L, Cooper D and Chen J
£230,000 Bristol-Myers Squibb (01-06-2021 - 30-11-2022)