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Dr Jianmin Chen

Jianmin Chen

Postdoctoral Researcher

William Harvey Research Institute
Queen Mary University of London



I am interested to study the switching of phenotypes and alterations in phagocytosis activity of macrophages upon pharmaceutical treatments in vitro. Biogel-elicited macrophages or bone marrow-derived macrophages are cultured. Phenotypes and phagocytosis activity of macrophages are determined by flow cytometry.


Publications of specific relevance to Predictive in vitro Models


Chen J, Norling LV, Mesa JG, de Paula Silva M, Burton SE, Reutelingsperger C, Perretti M and Cooper D (2021). Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritis. Proceedings of The National Academy of Sciences of The United States of America  vol. 118, (38) 10.1073/pnas.2020385118
De Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M, Gaffney A, Brennan E, Kantharidis P, Cooper ME, Leroy X, Perretti M, Gilroy D, Godson C and Guiry PJ (2021). Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4Mimetics (QNX-sLXms). Journal of Medicinal Chemistry  vol. 64, (13) 9193-9216. 10.1021/acs.jmedchem.1c00403


Chen J, Purvis GSD, Collotta D, Zoubi SA, Sugimoto MA, Cacace A, Martin L, Colas RA, Collino M, Dalli J and Thiemermann C (2020). RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial Clearance. Frontiers Media  Frontiers in Immunology  vol. 11, 2080-2080. 10.3389/fimmu.2020.02080


de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C and Guiry PJ (2019). Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms). European Journal of Medicinal Chemistry  vol. 162, 80-108. 10.1016/j.ejmech.2018.10.049


Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C and Ahluwalia A (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. Faseb J  fj201701303-fj201701303. 10.1096/fj.201701303R
Khan AI, Kapoor A, Chen J, Martin L, Rogazzo M, Mercier T, Decosterd L, Collino M and Thiemermann C (2018). The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction. Shock  vol. 49, (6) 675-681. 10.1097/SHK.0000000000000963


Purvis GSD, Chiazza F, Chen J, Loiola RA, Martin L, Fountoulakis N, Gnudi L, Collino M, Thiemermann C and Solito E (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Springer Verlag  Diabetologia  10.1007/s00125-017-4469-y
Johnson FL, Patel NSA, Purvis GSD, Chiazza F, Chen J, Sordi R, Hache G, Merezhko VV, Collino M, Yaqoob MM and Thiemermann C (2017). Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis. J Am Heart Assoc  vol. 6, (7) 10.1161/JAHA.116.005092
Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M, Thiemermann C and Schuerholz T (2017). The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men. Frontiers Media  Front Immunol  vol. 8, 681-681. 10.3389/fimmu.2017.00681


Chen J and Thiemermann C (2016). Selenium and niacin for sepsis therapy: The sum is greater than its parts. Critical Care Medicine  vol. 44, (6) 1256-1257. 10.1097/CCM.0000000000001493
Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N, Perretti M, Hobbs A, Collino M, Yaqoob M and THIEMERMANN C (2016). IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. American Society of Nephrology  Journal of The American Society of Nephrology  10.1681/ASN.2015060670


Gobbetti T, Coldewey SM, Chen J, McArthur S, Le Faouder P, Cenac N, Flower RJ, Thiemermann C and Perretti M (2014). Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsis. Proceedings of The National Academy of Sciences of The United States of America  vol. 111, (52) 18685-18690. 10.1073/pnas.1410938111
Chen J, Chiazza F, Collino M, Patel NSA, Coldewey SM and Thiemermann C (2014). Gender dimorphism of the cardiac dysfunction in murine sepsis: Signalling mechanisms and age-dependency. Plos One  vol. 9, (6) 10.1371/journal.pone.0100631


Grants of specific relevance to Predictive in vitro Models
Cardiomyopathy in RA
Perretti M, Norling L, Cooper D and Chen J
£230,000 Bristol-Myers Squibb (01-06-2021 - 30-11-2022)