Dr Jianmin Chen
Lecturer in Inflammation and Cardiovascular Medicine; Versus Arthritis Career Development Fellow
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Cardiomyopathy, HFpEF, Rheumatoid arthritis, Immune cells, Metabolism, Inflammation
Interests
I am interested in modeling the impact of arthritic synovial inflammation on the heart using interconnected organ-on-a-chip systems. Microfluidics which are introduced through an ibidi pump-based system can connect the two organ models, enabling the study of complex multicellular interactions driving cardiac fibrosis. This model will provide valuable insights into disease mechanisms and serve as a platform for screening and evaluating new therapeutics for both arthritis treatment and cardiac protection.Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models2025
Formyl-peptide receptor type 2 activation mitigates heart and lung damage in inflammatory arthritisMargraf A, Chen J, Christoforou M, Claria-Ribas P, Henriques Schneider A, Cecconello C, Bu W, Imbert PRC, Wright TD, Russo S, Blacksell IA, Koenis DS, Dalli J, Lupisella JA, Wurtz NR, Garcia RA, Cooper D, Norling LV and Perretti M
Embo Molecular Medicine, Springer Nature, 1-31.
03-04-2025
2024
Pro-resolving lipid mediators and therapeutic innovations in resolution of inflammationPeh HY and Chen J
Pharmacology & Therapeutics, Elsevier vol. 265
18-11-2024
Editorial: Cardiometabolic diseases and inflammatory responsesSuffee N, Le Goff W and Chen J
Frontiers in Immunology, Frontiers vol. 15
01-03-2024
2023
The Annexin-A1 mimetic RTP-026 promotes acute cardioprotection through modulation of immune cell activationChen J, Oggero S, Cecconello C, Dalli J, Hayat H, Hjiej Andaloussi A, Sanni S, Jonassen TE and Perretti M
Pharmacological Research, Elsevier vol. 198
21-11-2023
Formyl Peptide Receptor Type 2 Deficiency in Myeloid Cells Amplifies Sepsis-Induced Cardiac DysfunctionChen J, Austin-Williams S, O'Riordan CE, Claria-Ribas P, Sugimoto MA, Norling LV, Thiemermann C and Perretti M
Journal of Innate Immunity, Karger Publishers vol. 15 (1), 548-561.
01-01-2023
2022
Targeting the Annexin A1-FPR2/ALX pathway for host-directed therapy in dengue diseaseCosta VV, Sugimoto MA, Hubner J, Bonilha CS, Queiroz-Junior CM, Gonçalves-Pereira MH, Chen J, Gobbetti T, Rodrigues GOL, Bambirra JL, Passos IB, Lopes CEM, Moreira TP, Bonjour K, Melo RC, Oliveira MA, Andrade MVM, Sousa LP, Souza DG, da Costa Santiago H, Perretti M and Teixeira MM
Elife, Elife vol. 11
16-03-2022
20‐hydroxyeicosatetraenoic acid (20‐HETE) is a pivotal endogenous ligand for TRPV1‐mediated neurogenic inflammation in the skinHamers A, Primus CP, Whitear C, Kumar NA, Masucci M, Moreira SAM, Rathod K, Chen J, Bubb K, Colas R, Khambata RS, Dalli J and Ahluwalia A
British Journal of Pharmacology, Wiley vol. 179 (7), 1450-1469.
14-02-2022
2021
Inorganic nitrate attenuates cardiac dysfunction: roles for xanthine oxidoreductase and nitric oxideGee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP, Filomena F, Nuredini G, Ibrahim AS, Khambata RS, Gupta AK, Moon JC, Kapil V and Ahluwalia A
British Journal of Pharmacology, Wiley vol. 179 (20), 4757-4777.
06-10-2021
Annexin A1 attenuates cardiac diastolic dysfunction in mice with inflammatory arthritisChen J, Norling LV, Mesa JG, Silva MDP, Burton SE, Reutelingsperger C, Perretti M and Cooper D
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 118 (38)
15-09-2021
Asymmetric Synthesis and Biological Screening of Quinoxaline-Containing Synthetic Lipoxin A4 Mimetics (QNX-sLXms)de Gaetano M, Tighe C, Gahan K, Zanetti A, Chen J, Newson J, Cacace A, Marai M, Gaffney A, Brennan E, Kantharidis P, Cooper ME, Leroy X, Perretti M, Gilroy D, Godson C and Guiry PJ
Journal of Medicinal Chemistry, American Chemical Society (Acs) vol. 64 (13), 9193-9216.
17-06-2021
2020
RvE1 Attenuates Polymicrobial Sepsis-Induced Cardiac Dysfunction and Enhances Bacterial ClearanceChen J, Purvis GSD, Collotta D, Zoubi SA, Sugimoto MA, Cacace A, Martin L, Colas RA, Collino M, Dalli J and Thiemermann C
Frontiers in Immunology, Frontiers Media vol. 11, 2080-2080.
02-09-2020
Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemiaAziz Q, Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S, Hobbs AJ, Thiemermann C and Tinker A
Journal of Molecular Medicine, Springer Science and Business Media Llc
06-07-2020
Immunohistochemistry of Kidney a-SMA, Collagen 1, and Collagen 3, in A Novel Mouse Model of Reno-cardiac Syndrome.Kieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C and Yaqoob MM
Bio-Protocol, Bio-Protocol vol. 10 (18)
01-01-2020
2019
Long residence time adenosine A1 receptor agonists produce sustained wash-resistant antilipolytic effect in rat adipocytesYun Y, Chen J, Liu R, Chen W, Liu C, Wang R, Hou Z, Yu Z, Sun Y, IJzerman AP, Heitman LH, Yin X and Guo D
Biochemical Pharmacology, Elsevier vol. 164, 45-52.
21-03-2019
2018
Linagliptin Attenuates the Cardiac Dysfunction Associated With Experimental Sepsis in Mice With Pre-existing Type 2 Diabetes by Inhibiting NF-κBAl Zoubi S, Chen J, Murphy C, Martin L, Chiazza F, Collotta D, Yaqoob MM, Collino M and Thiemermann C
Frontiers in Immunology, Frontiers vol. 9
18-12-2018
A novel model of reno-cardiac syndrome in the C57BL/ 6 mouse strainKieswich JE, Chen J, Alliouachene S, Caton PW, McCafferty K, Thiemermann C and Yaqoob MM
Bmc Nephrology, Springer Nature vol. 19 (1)
01-12-2018
Asymmetric synthesis and biological evaluation of imidazole- and oxazole-containing synthetic lipoxin A4 mimetics (sLXms)de Gaetano M, Butler E, Gahan K, Zanetti A, Marai M, Chen J, Cacace A, Hams E, Maingot C, McLoughlin A, Brennan E, Leroy X, Loscher CE, Fallon P, Perretti M, Godson C and Guiry PJ
European Journal of Medicinal Chemistry, Elsevier vol. 162, 80-108.
23-10-2018
Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis.Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C and Ahluwalia A
Faseb J, fj201701303-fj201701303.
28-06-2018
The Antimalarial Drug Artesunate Attenuates Cardiac Injury in A Rodent Model of Myocardial Infarction.Khan AI, Kapoor A, Chen J, Martin L, Rogazzo M, Mercier T, Decosterd L, Collino M and Thiemermann C
Shock vol. 49 (6), 675-681.
01-06-2018
2017
Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetesPurvis GSD, Chiazza F, Chen J, Loiola RA, Martin L, Fountoulakis N, Gnudi L, Collino M, Thiemermann C and Solito E
Diabetologia, Springer Verlag
30-10-2017
Inhibition of IκB Kinase at 24 Hours After Acute Kidney Injury Improves Recovery of Renal Function and Attenuates Fibrosis.Johnson FL, Patel NSA, Purvis GSD, Chiazza F, Chen J, Sordi R, Hache G, Merezhko VV, Collino M, Yaqoob MM and Thiemermann C
J Am Heart Assoc vol. 6 (7)
03-07-2017
The β-d-Endoglucuronidase Heparanase Is a Danger Molecule That Drives Systemic Inflammation and Correlates with Clinical Course after Open and Endovascular Thoracoabdominal Aortic Aneurysm Repair: Lessons Learnt from Mice and Men.Martin L, Gombert A, Chen J, Liebens J, Verleger J, Kalder J, Marx G, Jacobs M, Thiemermann C and Schuerholz T
Front Immunol, Frontiers Media vol. 8, 681-681.
12-06-2017
2016
Selenium and Niacin for Sepsis TherapyChen J and Thiemermann C
Critical Care Medicine, Wolters Kluwer vol. 44 (6), 1256-1257.
01-06-2016
IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKDChen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N, Perretti M, Hobbs A, Collino M, Yaqoob M and THIEMERMANN C
Journal of The American Society of Nephrology, American Society of Nephrology
06-05-2016
The association of depressed angiogenic factors with reduced capillary density in the Rhesus monkey model of myocardial ischemiaZhang W, Zhao X, Xiao Y, Chen J, Han P, Zhang J, Fu H and Kang YJ
Metallomics, Oxford University Press (Oup) vol. 8 (7), 654-662.
01-01-2016
2014
Nonredundant protective properties of FPR2/ALX in polymicrobial murine sepsisGobbetti T, Coldewey SM, Chen J, McArthur S, le Faouder P, Cenac N, Flower RJ, Thiemermann C and Perretti M
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (52), 18685-18690.
15-12-2014
Gender Dimorphism of the Cardiac Dysfunction in Murine Sepsis: Signalling Mechanisms and Age-DependencyChen J, Chiazza F, Collino M, Patel NSA, Coldewey SM and Thiemermann C
Plos One, Public Library of Science (Plos) vol. 9 (6)
19-06-2014
2013
Decreases in Electrocardiographic R-Wave Amplitude and QT Interval Predict Myocardial Ischemic Infarction in Rhesus Monkeys with Left Anterior Descending Artery LigationSun X, Cai J, Fan X, Han P, Xie Y, Chen J, Xiao Y and Kang YJ
Plos One, Public Library of Science (Plos) vol. 8 (8)
13-08-2013
2012
Immunohistochemical detection of differentially localized up-regulation of lysyl oxidase and down-regulation of matrix metalloproteinase-1 in rhesus monkey model of chronic myocardial infarctionXie Y, Chen J, Han P, Yang P, Hou J and Kang YJ
Experimental Biology and Medicine, Frontiers vol. 237 (7), 853-859.
01-07-2012
Grants
Grants of specific relevance to Predictive in vitro Models
PHEast: Phenylalanine promotes cardiac dysfunction by driving hyperphagiaGabor Czibik and Jianmin Chen
£320,385 Barts and the London Charity
01-01-2025 - 31-12-2028
Unravelling the cardiovascular implications of rheumatoid arthritis: A comprehensive investigation using cardiac MRI and novel biomarkersJianmin Chen
£5,000 WHRF William Harvey Research Foundation
14-10-2024 - 13-08-2027
Blood analysis protocol: Efficacy of RTP026 in MI patientsMauro Perretti, Jianmin Chen and Sharmilee Gnanapavan
£261,605 William Harvey Research Limited
01-09-2024 - 28-02-2027
LPS-induced endotoxaemia/sepsis syndromeJianmin Chen
£13,904 William Harvey Research Limited
01-08-2024 - 31-10-2026
Targeting heart failure with preserved ejection fraction in settings of arthritisJianmin Chen and Federica Marelli-Berg
£121,068 Heart Research UK
01-01-2023 - 30-06-2026
Modelling cardiomyopathy in inflammatory arthritis to define mechanisms and guide therapeutic strategiesJianmin Chen
£469,692 AR-UK Versus Arthritis
18-08-2022 - 17-07-2027
Joint Attack: Arthritis and metabolic syndrome in the HFpEF comorbidity networkJianmin Chen and Dianne Cooper
£75,000 Barts and the London Charity
18-04-2024 - 31-05-2025
Hypertension and rheumatoid arthritis as co-morbidities in heart failureDianne Cooper and Jianmin Chen
£49,919 Barts and the London Charity
17-10-2022 - 31-01-2024