Dr Egle Solito

Egle Solito

Reader in Immunobiology

The William Harvey Research Institute
Queen Mary University of London
www.qmul.ac.uk/whri/people/academic-staff/items/solitoegle.html
ORCID X

Research

Blood-Brain Barrier (BBB), Immunobiology, Inflammation, Cerebrovascular Dementia, Ageing, Metabolism

Infectious Disease and Inflammation Models, Neuronal Models

Interests

Development of human in vitro model of Blood-Brain Barrier (BBB) for the study of drug delivery and ex vivo system biology of the CNS and associated pathologies

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Retraction Note: Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes

Diabetologia, Springer Nature vol. 68 (7), 1589-1589.  
29-04-2025
Publisher Correction: The glucose transporter 2 regulates CD8+ T cell function via environment sensing
Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M et al.
Nature Metabolism, Springer Nature vol. 7 (3), 634-634.  
25-02-2025

2024

Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor

Gut Microbes, Taylor & Francis vol. 16 (1), 2431651-2431651.  
24-11-2024
Developmental priming of early cerebrovascular ageing: Implications across a lifetime
Stolp HB, Solito E
International Journal of Geriatric Psychiatry, Wiley vol. 39 (4) 
01-04-2024

2023

The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing.
Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M et al.
Nature Metabolism, Nature Research 
26-10-2023
The Immune Response to SARS-CoV-2 Vaccine in a Cohort of Family Pediatricians from Southern Italy
Cortese P, Amato F, Davino A, De Franchis R, Esposito S, Zollo I, Di Domenico M, Solito E et al.
Cells, Mdpi vol. 12 (11) 
23-05-2023
ALDOC- and ENO2- driven glucose metabolism sustains 3D tumor spheroids growth regardless of nutrient environmental conditions: a multi-omics analysis
De Vitis C, Battaglia AM, Pallocca M, Santamaria G, Mimmi MC, Sacco A, De Nicola F, Gaspari M et al.
Journal of Experimental & Clinical Cancer Research, Springer Nature vol. 42 (1) 
22-03-2023

2022

Promiscuous Receptors and Neuroinflammation: The Formyl Peptide Class
Wickstead ES, Solito E, Mcarthur S
Life, Mdpi vol. 12 (12) 
02-12-2022
Circulating c-Met–Expressing Memory T Cells Define Cardiac Autoimmunity
Fanti S, Stephenson E, Rocha-Vieira E, Protonotarios A, Kanoni S, Shahaj E, Longhi MP, Vyas VS et al.
Circulation, Wolters Kluwer vol. 146 (25), 1930-1945.  
23-11-2022
Does Neuroinflammation Underlie the Cognitive Changes Observed With Dietary Interventions?
Robbins JP, Solito E
Frontiers in Neuroscience, Frontiers vol. 16 
10-05-2022

2021

Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
Hoyles L, Pontifex M, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S et al.
Microbiome, Biomed Central 
27-11-2021
The Impact of Ageing on the CNS Immune Response in Alzheimer’s Disease
Chee SEJ, Solito E
Frontiers in Immunology, Frontiers vol. 12 
17-09-2021
A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice

Frontiers in Immunology vol. 12, 701275-701275.  
19-07-2021
Annexin-A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology
Reis M, Watts H, Mota B, Yanez-lopez M, Donat C, Baxan N, Pickering J, Chaw T et al.
Brain: a Journal of Neurology, Oxford University Press (Oup) 
21-06-2021
A synthetic peptide designed to neutralise lipopolysaccharides attenuates metaflammation and diet-induced metabolic derangements in mice
Mohammad S, Al Zoubi S, Krieg N, Wissuwa B, Baragetti A, Brandenburg K, Collotta D
 
01-01-2021

2020

Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming
Solito E, Marelli-Berg F, Fanti S, Cheung K, Mauro C, Wang G, Nair A, Fu H et al.
Nature Communications, Nature Research (Part of Springer Nature) vol. 11 
17-07-2020
Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures
Majkowska A, Redondo-Gómez C, Rice A, Gonzalez M, Inostroza-Brito KE, Collin EC, Rodriguez-Cabello JC, Del Rio Hernandez AE et al.
Frontiers in Materials, Frontiers vol. 7 
16-06-2020

2019

Mitochondrial mass governs the extent of human T cell senescence
Callender L, Carroll E, BOBER E, Akbar A, Solito E, Henson S
Aging Cell, John Wiley & Sons Ltd vol. 19 (2) 
02-12-2019
Changes in vascular permeability in the spinal cord contribute to chemotherapy- induced neuropathic pain
Solito E, Montague-Cardoso, K, Pitcher T, Chisolm K, Salera G, Lindstrom E, Hewitt E, Malcangio M
Brain Behaviour and Immunity, Elsevier 
24-10-2019
The GR-ANXA1 pathway is a pathological player and a candidate target in epilepsy
Solito E, Zub E, Canet G, Garbelli R, Blaquiere M, Rossini L, Pastori C, Sheikh M et al.
The Faseb Journal, Federation of American Society of Experimental Biology 
16-10-2019
Reduced Annexin A1 expression associates with disease severity and inflammation in multiple sclerosis patients
Solito E, Colamatteo A, Maggioli E, Azevedo Loiola R, Sheikh M, Cali G, Bruzzese D, Maniscalco T et al.
Journal of Immunology, American Association of Immunologists 
05-09-2019
Control of expression and activity of peroxisome proliferated-activated receptor γ by Annexin A1 on microglia during efferocytosis.
da Rocha GHO, Loiola RA, Pantaleão LDN, Reutelingsperger C, Solito E, Farsky SHP
Cell Biochemistry and Function, Wiley 
03-09-2019
Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1
Loiola RA, Wickstead ES, Solito E, Mcarthur S
Frontiers in Endocrinology, Frontiers Media 
26-06-2019
Annexin-A1: therapeutic potential in microvascular disease.
SOLITO EGLE, PURVIS G, THIEMERMANN C
Frontiers in Immunology, Frontiers Media 
30-04-2019
Administration of annexin-A1 reduces tau phosphorylation in the tau-P301L mouse model
Pickering J, Ries M, Solito E
 
01-01-2019

2018

Connections of Annexin A1 and Translocator Protein-18 KDa on Toll Like Receptor Stimulated BV-2 Cells.
SOLITO E
Exp Cell Res. 
09-04-2018
Annexin A1: Uncovering the Many Talents of an Old Protein
SOLITO E, SHEIKH M
International Journal of Molecular Sciences, Mdpi Ag vol. 19 
31-03-2018
Is AnnexinA1 The Miracle Drug For Diabetes?
S. D. Purvis G, Solito E
Science Trends, Science Trends 
01-01-2018

2017

Endogenous Annexin-A1 is a Protective Determinant in HFD-induced Insulin Resistance and Diabetic Nephropathy
Purvis GSD, Chiazza F, Collino M, Solito E, Thiemermann C
FASEB. 
01-04-2017
Endogenous annexin-A1 is a protective determinant in high-fat diet (HFD)-induced insulin resistance and diabetic nephropathy
Purvis GSD, Chiazza F, Solito E, Collino M, Thiemermann C
European Shock Society. 
01-03-2017
Role of annexin-A1 on blood-brain barrier functionality
Purvis GSD, Loiola RA, Keswich J, Theimermann C
 
01-01-2017

2016

The restorative role of annexin A1 at the blood–brain barrier
McArthur S, Loiola RA, Maggioli, E, Errede M, Virgintino D, SOLITO E
Fluids and Barriers of The Cns, Biomed Central vol. 13 (17) 
21-09-2016
The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide
SOLITO E, Loiola R, Ries M, Shah U, Gentleamn S, Sastre M
Journal of Neuroinflammation, Biomed Central vol. 13 
02-09-2016
The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil
Sinniah A, Yazid S, Perretti M, Solito E, Flower RJ
International Immunopharmacology, Elsevier vol. 32, 87-95.  
21-01-2016

2015

Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking

Brain Behavior and Immunity, Elsevier vol. 51, 212-222.  
29-08-2015
Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease
Yazid S, Gardner PJ, Carvalho L, Chu CJ, Flower RJ, Solito E, Lee RWJ, Ali RR et al.
Journal of Autoimmunity, Elsevier vol. 58, 1-11.  
22-01-2015
Metabolic Syndrome and the Immunological Affair with the Blood–Brain Barrier
Mauro C, De Rosa V, Marelli-Berg F, Solito E
Frontiers in Immunology, Frontiers vol. 5 
05-01-2015

2014

Relationship between HPV and the biomarkers annexin A1 and p53 in oropharyngeal cancer.
Queiroz CJDS, Nakata CMDAG, Solito E, Damazo AS
Infect Agent Cancer vol. 9 
01-01-2014
ANNEXIN A1 AND PPARγ ON RESOLUTION OF INFLAMMATION
Farsky SHP, Santin JR, Takahama C, Machado ID, Teixeira S, Muscara MN, Pitta IR, Solito E et al.
 
01-01-2014
Relationship between HPV and biomarkers annexin A1 and P53 in oropharyngeal cancer
dos Santos Queiroz CJ, de Amorim Gomes Nakata CM, Solito E, Damazo AS
Pathology, Elsevier vol. 46 
01-01-2014

2013

Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro.
Girol AP, Mimura KKO, Drewes CC, Bolonheis SM, Solito E, Farsky SHP, Gil CD, Oliani SM
J Immunol vol. 190 (11), 5689-5701.  
01-06-2013
Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications.
Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J et al.
Proc Natl Acad Sci U S A vol. 110 (3), 832-841.  
15-01-2013
Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1.
Yazid S, Sinniah A, Solito E, Calder V, Flower RJ
Plos One vol. 8 (3) 
01-01-2013

2012

Evidence from in vitro and in vivo studies showing that nuclear factor-κB within the pituitary folliculostellate cells and corticotrophs regulates adrenocorticotrophic hormone secretion in experimental endotoxaemia.
Mehet DK, Philip J, Solito E, Buckingham JC, John CD
J Neuroendocrinol vol. 24 (6), 862-873.  
01-06-2012
Microglia function in Alzheimer's disease.
Solito E, Sastre M
Front Pharmacol vol. 3 
01-01-2012

2010

Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia.
McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE, Solito E
J Immunol vol. 185 (10), 6317-6328.  
15-11-2010
Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization.
Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M, Flower RJ
Arterioscler Thromb Vasc Biol vol. 30 (9), 1718-1724.  
01-09-2010
Anti-allergic drugs and the Annexin-A1 system.
Yazid S, Ayoub SS, Solito E, McArthur S, Vo P, Dufton N, Flower RJ
Pharmacol Rep vol. 62 (3), 511-517.  
01-01-2010

2009

Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization.
McArthur S, Yazid S, Christian H, Sirha R, Flower R, Buckingham J, Solito E
Faseb J vol. 23 (11), 4000-4010.  
01-11-2009
Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1.
Yazid S, Solito E, Christian H, McArthur S, Goulding N, Flower R
Biochem Pharmacol vol. 77 (12), 1814-1826.  
15-06-2009

2008

Further studies on the rapid glucocorticoid effects in the U937 monocytic cell line and its potentiation by cromoglycate-like drugs
Yazid S, Solito E, Christian H, Goulding N
Fund Clin Pharmacol vol. 22, 47-47.  
01-08-2008
A critical role for the anti-inflammatory protein annexin A1 in microglial phagocytosis
McArthur S, Prasongchean W, Gillies G, Solito E
Fund Clin Pharmacol vol. 22, 23-23.  
01-08-2008
Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia
Damazo AS, Flower RJ, Solito E, Oliani SM
Inflamm Res vol. 57 (3), 97-103.  
01-03-2008
Membrane-induced folding and structure of membrane-bound annexin A1 N-terminal peptides: Implications for annexin-induced membrane aggregation
Hu NJ, Bradshaw J, Lauter H, Hofmann A
Biophys J vol. 94 (5), 1773-1781.  
01-03-2008
Annexin A1 in the brain--undiscovered roles?
Solito E, McArthur S, Christian H, Gavins F, Buckingham JC, Gillies GE
Trends Pharmacol Sci vol. 29 (3), 135-142.  
01-03-2008

2007

Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides
John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E et al.
Faseb J vol. 21 (4), 1037-1046.  
01-04-2007

2006

Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue
Warne JP, John CD, Christian HC, Morris JF, Flower RJ, Solito E, Gillies GE
Am J Physiol-Endoc M vol. 291 (6), E1264-E1273.  
01-12-2006
Antiflammin-2 activates the human formyl-peptide receptor like 1.
Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ, Solito E, Perretti M
Scientificworldjournal vol. 6, 1375-1384.  
25-10-2006
Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface
FLOWER RJ, Buckingham JC, Tierney T, Festa M
Faseb J vol. 20 (9), 1498-1500.  
01-07-2006
Annexin 1: a mediator of glucocorticoid action at the neuroendocrine-immune interface.
Buckingham J, John C, Solito E, Flower R
Acta Pharmacol Sin vol. 27, 306-306.  
01-07-2006
Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface.
Solito E, Christian HC, Festa M, Mulla A, Tierney T, Flower RJ, Buckingham JC
Faseb J vol. 20 (9), 1498-1500.  
01-07-2006
Down-regulation of annexin-1 expression in thyroid cancers is associated with tumour aggressiveness
Petrella A, Festa M, Ercolino SF, Zerilli M, Solito E
Acta Pharmacol Sin vol. 27, 65-65.  
01-07-2006
Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation.
Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E, Parente L
Cancer Biol Ther vol. 5 (6), 643-647.  
01-06-2006
The cellular exportation of annexin 1 requires post-translational modification
Buckingham JC, Mulla A, Tierney T, Morris J
 
01-05-2006
Annexin 1 dependent actions of glucocorticoids in the anterior pituitary gland - role of the formyl peptide receptor family
Buckingham JC, Sahni V, Morris JF
 
01-05-2006
In vitro and in vivo studies on CCR10 regulation by Annexin A1 (vol 580, pg 1431, 2006)
Rodrigues-Lisoni FC, Mehet DK, Peitl P, John CD, da Silva WA, Buckingham JC
Febs Lett vol. 580 (7), 1908-1908.  
20-03-2006
Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement
Hayhoe RPG, Kamal AM, Solito E, Flower RJ, Cooper D, Perretti M
Blood vol. 107 (5), 2123-2130.  
01-03-2006
In vitro and in vivo studies on CCR10 regulation by Annexin A1.
Rodrigues-Lisoni FC, Mehet DK, Peitl P, John CD, da Silva Júnior WA, Tajara E, Buckingham JC, Solito E
Febs Lett vol. 580 (5), 1431-1438.  
20-02-2006
Annexin 1, glucocorticoids, and the neuroendocrine-immune interface
Buckingham JC, John CD, Solito E, Tierney T, Flower RJ, Chrousos GP, Kaltsas GA, Mastorakos G
 
01-01-2006

2005

Induction of annexin-1 during TRAIL-induced apoptosis in thyroid carcinoma cells.
Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G
Cell Death Differ vol. 12 (10), 1358-1360.  
01-10-2005
Annexin A1: From gene organization to physiology
Rodrigues-Lisoni FC, Oliani S, Buckingham J, Solito E, Tajara EH
Annexins vol. 2 (2), e2-e6.  
01-04-2005
Correlation between the antiinflammatory protein annexin 1 (lipocortin 1) and serum cortisol in subjects with normal and dysregulated adrenal function.
Mulla A, Leroux C, Solito E, Buckingham JC
J Clin Endocrinol Metab vol. 90 (1), 557-562.  
01-01-2005

2004

Annexin 1 and neutrophil apoptosis
Perretti M, Solito E
Biochemical Society Transactions vol. 32, 507-510.  
01-06-2004
Annexin 1 and the regulation of endocrine function
John CD, Christian HC, Morris JF, Flower RJ
Trends Endocrin Met vol. 15 (3), 103-109.  
01-04-2004
Annexin 1: more than an anti-phospholipase protein.
Parente L, Solito E
Inflamm Res vol. 53 (4), 125-132.  
01-04-2004
Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone-secreting carcinoma.
Mulla A, Christian HC, Solito E, Mendoza N, Morris JF, Buckingham JC
Clin Endocrinol (Oxf) vol. 60 (1), 107-119.  
01-01-2004

2003

Evidence from studies on co-cultures of TtT/GF and AtT20 cells that Annexin 1 acts as a paracrine or juxtacrine mediator of the early inhibitory effects of glucocorticoids on ACTH release.
Tierney T, Christian HC, Morris JF, Solito E, Buckingham JC
J Neuroendocrinol vol. 15 (12), 1134-1143.  
01-12-2003
Kinase-dependent regulation of the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin 1 peptides.
John CD, Christian HC, Morris JF, Flower RJ, Solito E, Buckingham JC
J Neuroendocrinol vol. 15 (10), 946-957.  
01-10-2003
Annexin 1: a paracrine/juxtacrine mediator of glucorticoid in the action in the neuroendocrine system
Buckingham JC, Solito E, John C, Tierney T, Flower R
 
01-09-2003
Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system.
Buckingham JC, Solito E, John C, Tierney T, Taylor A, Flower R, Christian H, Morris J
Cell Biochem Funct vol. 21 (3), 217-221.  
01-09-2003
Dexamethasone enhances interaction of endogenous annexin 1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-937.
de Coupade C, Solito E, Levine JD
Br J Pharmacol vol. 140 (1), 133-145.  
01-09-2003
A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils
Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S, Perretti M
Faseb J vol. 17 (9), 1544-+.  
01-06-2003
Attenuation of glucocorticoid functions in an Anx-A1-/- cell line.
Croxtall JD, Gilroy DW, Solito E, Choudhury Q, Ward BJ, Buckingham JC, Flower RJ
Biochem J vol. 371 (Pt 3), 927-935.  
01-05-2003
Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase c, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase
Solito E, Mulla A, Morris JF
Endocrinology vol. 144 (4), 1164-1174.  
01-04-2003
Exogenous annexin 1 promotes human neutrophil apoptosis
Solito E, Perretti M
 
01-04-2003
Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system.
FLOWER RJ, John C, Solito E, Morris J, Taylor A
Cell Biochemistry and Function. vol. 21 (3), 217-221.  
01-01-2003
A novel calcium-dependent pro-apoptotic effect of annexin 1 on human neutrophils.
PERRETTI M, Marullo S, Buckingham JC, Russo-Marie F, Solito E, Kamal A
 
01-01-2003
Kinase-Dependent Regulation of the Secretion of Thyrotrophin and Luteinizing Hormone By Glucocorticoids and Annexin 1 Peptides.
FLOWER RJ, Morris JF, Christian HC, Buckingham JC
J Neuroendocrinol. vol. 15 (10), 946-957.  
01-01-2003

2002

Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor.
Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E, Serhan CN
Nat Med vol. 8 (11), 1296-1302.  
01-11-2002
Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model.
Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E, Pitzalis C
J Immunol vol. 169 (4), 2085-2092.  
15-08-2002
Annexin 1 interacts with L-selectin following neutrophil adhesion to endothelial cells
Perretti M, La M, Solito E
 
22-03-2002
Monocytic cells over-expressing annexin 1 have reduced transmigration in vitro and elicitation in vivo
Perretti M, Blades MC, Wheller SK, Wahid S, Solito E, Pitzalis C
 
20-03-2002
LPS acts via IL-6 and IL-1 to modulate the expression and phosphorylation of annexin 1 in cell lines derived from the putative microglia of the neuroendocrine system.
Mulla A, Buckingham JC
Brit J Pharmacol vol. 135 
01-03-2002
Dexamethasone induces serine phosphorylation of annexin 1: Involvement of PKC and PI3-kinase
Solito E, Mulla A
Brit J Pharmacol vol. 135 
01-03-2002
Lipocortin 1 (Annexin 1)
Solito E, Mulla A, Flower RJ
In Wiley Encyclopedia of Molecular Medicine, Wiley 
15-01-2002
Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: roles of the N-terminal domain and protein kinase C.
FLOWER RJ, Buckingham J, Christian H, Solito E, John C, Cover P
Endocrinology. vol. 143 (8), 3060-3070.  
01-01-2002

2001

Cytokine modulation of liver annexin 1 expression during experimental endotoxemia
de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M, Solito E
Am J Pathol vol. 159 (4), 1435-1443.  
01-10-2001
An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro.
Kamal AM, Smith SF, De Silva Wijayasinghe M, Solito E, Corrigan CJ
Clin Exp Allergy vol. 31 (7), 1116-1125.  
01-07-2001
Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics
Perretti M, Getting SJ, Solito E, Murphy PM, Gao JL
Am J Pathol vol. 158 (6), 1969-1973.  
01-06-2001
Dexamethasone induces serine phosphorylation of annexin 1 in pituitary cells and suppresses ACTH release by a PKC-dependent mechanism.
John CD, Solito E, Morris JF, Flower RJ
Brit J Pharmacol vol. 133, U20-U20.  
01-05-2001
Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation
Solito E, de Coupade C, Canaider S, Goulding NJ, Perretti M
Brit J Pharmacol vol. 133 (2), 217-228.  
01-05-2001

2000

Extracellular annexin-1 accelerates apoptosis of human polymorphonuclears neutrophils.
Solito E, Tissot M, Russo-Marie F
Mol Biol Cell vol. 11, 462A-463A.  
01-12-2000
Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment.
D'Amico M, Di Filippo C, La M, Solito E, McLean PG, Flower RJ, Oliani SM, Perretti M
Faseb J vol. 14 (13), 1867-1869.  
01-10-2000
Annexin 1 binds to U937 monocytic cells and inhibits their adhesion to microvascular endothelium: involvement of the alpha 4 beta 1 integrin.
Solito E, Romero IA, Marullo S, Russo-Marie F, Weksler BB
J Immunol vol. 165 (3), 1573-1581.  
01-08-2000
Expression of annexins 1 and 5 in human pituitary tumours
Mulla A, Christian H, Morris J, Mendoza N
J Physiol-London vol. 525, 53P-54P.  
01-06-2000
Extracellular Annexin 1 induces apoptosis of human polymorphonuclear neutrophils
Solito E, Tissot M, Russo-Marie F
Faseb J vol. 14 (8), A1357-A1357.  
11-05-2000
System A neutral amino acid transporter regulation by interleukin-1beta in human osteoarthritic synovial cells: evidence for involvement of prostaglandin E(2) as a second messenger.
Le Maire V, Solito E, Russo-Marie F, Hernvann A, Le Marechal H, Ekindjian OG, Aussel C
J Cell Physiol vol. 183 (1), 65-73.  
01-04-2000
Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I).
Canaider S, Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ, Perretti M
Life Sci vol. 66 (18), PL265-PL270.  
24-03-2000
Annexin 1 activates human neutrophils: A mechanism for its anti-inflammatory in vivo effect
Perretti M, Solito E, La M, D'Amico M
Faseb J vol. 14 (4), A8-A8.  
15-03-2000
Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin III SV40 T large antigen transgenic mice.
de Coupade C, Gillet R, Bennoun M, Briand P, Russo-Marie F, Solito E
Hepatology vol. 31 (2), 371-380.  
01-02-2000
Lipocortin 1 inhibits myocardial infarct by reducing local neutrophil infiltration
D'Amico M, Di Filippo C, Solito E
Brit J Pharmacol vol. 129, U56-U56.  
01-01-2000

1999

Annexin V counteracts apoptosis while inducing Ca(2+) influx in human lymphocytic T cells.
Gidon-Jeangirard C, Solito E, Hofmann A, Russo-Marie F, Freyssinet JM, Martínez MC
Biochem Biophys Res Commun vol. 265 (3), 709-715.  
30-11-1999
De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum.
Young KA, Hirst WD, Solito E, Wilkin GP
Glia vol. 26 (4), 333-343.  
01-06-1999
Increased apoptosis in cells overexpressing lipocortin 1
Canaider S, Solito E, Goulding NJ, Perretti M
Brit J Pharmacol vol. 126, U26-U26.  
01-03-1999
Evidence from in vivo and in vitro studies that the inhibitory actions of lipocortin 1 on anterior pituitary function require amino acid residues 13-26
John CD, Cover PO, Taylor AD, Morris JF, Solito E, Buckingham JC
Brit J Pharmacol vol. 126, U74-U74.  
01-03-1999
Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway.
Raguenes-Nicol C, Russo-Marie F, Domage G, Diab N, Solito E, Dray F, Mace JL, Streichenberger G
Biochem Pharmacol vol. 57 (4), 433-443.  
15-02-1999
Preferential accumulation of muscle type acylphosphatase in the nucleus during differentiation.
Raugei G, Degl'Innocenti D, Chiarugi P, Solito E, Modesti A, Ramponi G
Biochem Mol Biol Int vol. 47 (1), 127-136.  
01-01-1999

1998

Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1.
Lim LH, Solito E, Russo-Marie F, Flower RJ, Perretti M
Proc Natl Acad Sci U S A vol. 95 (24), 14535-14539.  
24-11-1998
U937 cells deprived of endogenous annexin 1 demonstrate an increased PLA2 activity.
Solito E, Raguenes-Nicol C, de Coupade C, Bisagni-Faure A, Russo-Marie F
Br J Pharmacol vol. 124 (8), 1675-1683.  
01-08-1998
IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein.
Solito E, de Coupade C, Parente L, Flower RJ, Russo-Marie F
Cytokine vol. 10 (7), 514-521.  
01-07-1998
Human annexin 1 is highly expressed during the differentiation of the epithelial cell line A 549: involvement of nuclear factor interleukin 6 in phorbol ester induction of annexin 1.
Solito E, de Coupade C, Parente L, Flower RJ, Russo-Marie F
Cell Growth Differ vol. 9 (4), 327-336.  
01-04-1998
Annexin V inhibits protein kinase C activity via a mechanism of phospholipid sequestration.
Dubois T, Mira JP, Feliers D, Solito E, Russo-Marie F, Oudinet JP
Biochem J vol. 330 ( Pt 3) (Pt 3), 1277-1282.  
15-03-1998

1997

Inhibition of neutrophil : endothelium interaction in murine post-capillary venules by lipocortin 1
Lim LHK, Getting SJ, Das AM, Flower RJ
Brit J Pharmacol vol. 122, U54-U54.  
01-12-1997
P-3-325 Steroid-induced expression of annexinin brain
Voermans PH, Go KG, Horst GJT, Parente L
Clinical Neurology and Neurosurgery, Elsevier vol. 99, s145-s146.  
01-07-1997
Expression of Annexin and Annexin-mRNA in Rat Brain Under Influence of Steroid Drugs
Voermans PH, Go KG, ter Horst GJ, Ruiters MHJ
In Brain Edema X, Springer Nature 222-224.  
01-01-1997
Expression of annexin and annexin-mRNA in rat brain under influence of steroid drugs.
Voermans PH, Go KG, ter Horst GJ, Ruiters MH, Solito E, Parente L
Acta Neurochir Suppl vol. 70, 222-224.  
01-01-1997

1996

Phospholipase A(2) activity and calpactin I levels in rat lymphokine-activated killer cells: Correlation with the cytotoxic activity
Cifone MG, Cironi L, Roncaioli P, Martinotti S, Cilenti L, Botti D, Parente L
Cell Immunol vol. 170 (2), 274-282.  
15-06-1996
Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta.
Ambrosetti DC, Palla E, Mirtella A, Galeotti C, Solito E, Navarra P, Parente L, Melli M
Eur J Biochem vol. 238 (2), 308-316.  
01-06-1996
Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F.
Voermans PH, Go KG, Horst GJ, Ruiters MH, Solito E, Parente L
Mediators Inflamm vol. 5 (5), 370-378.  
01-01-1996

1995

A new functional binding site for interleukin-1beta?
Parente L, Ambrosetti D, Palla E, Mirtella A, Galeotti CL
Pharmacological Research, Elsevier vol. 31 
01-01-1995

1994

Association between glucocorticosteroids and lipocortin 1.
Parente L
Trends Pharmacol Sci vol. 15 (10) 
01-10-1994
Dexamethasone-induced translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells.
Solito E, Nuti S, Parente L
Br J Pharmacol vol. 112 (2), 347-348.  
01-06-1994
Effect of steroids on brain lipocortin immunoreactivity.
Go KG, Zuiderveen F, De Ley L, Ter Haar JG, Parente L, Solito E, Molenaar WM
Acta Neurochir Suppl (Wien) vol. 60, 101-103.  
01-01-1994
The effect of steroid treatment on lipocortin immunoreactivity of rat brain.
Go KG, Ter Haar JG, de Ley L, Zuiderveen F, Parente L, Solito E, Molenaar WM
Mediators Inflamm vol. 3 (3), 177-180.  
01-01-1994
EFFECT OF STEROIDS ON BRAIN LIPOCORTIN IMMUNOREACTIVITY
GO KG, ZUIDERVEEN F, DELEY L, PARENTE L, SOLITO E, MOLENAAR WM
Acta Neurochir, 101-103.  
01-01-1994
DEXAMETHASONE INDUCES THE TRANSLOCATION OF LIPOCORTIN-1 TO THE MEMBRANE OF HUMAN MONOCYTIC U-937 CELLS
PARENTE L, NUTI S
Brit J Pharmacol vol. 111, P72-P72.  
01-01-1994
IDENTIFICATION OF ACTIVE-SITES OF INTERLEUKIN-1-BETA BY LOOP SUBSTITUTION AND SITE-DIRECTED MUTAGENESIS
SOLITO E, PALLA E, BENSI G, FASSINA G
Brit J Pharmacol vol. 111, P31-P31.  
01-01-1994

1993

Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids.
De Caterina R, Sicari R, Giannessi D, Paggiaro PL, Paoletti P, Lazzerini G, Bernini W, Solito E et al.
J Appl Physiol (1985) vol. 75 (6), 2368-2375.  
01-12-1993
Loop substitution as a tool to identify active sites of interleukin-1 beta.
Palla E, Bensi G, Solito E, Buonamassa DT, Fassina G, Raugei G, Spano F, Galeotti C et al.
J Biol Chem vol. 268 (18), 13486-13492.  
25-06-1993
CONCEIVABLE DIFFERENCE IN THE ANTIINFLAMMATORY MECHANISMS OF LIPOCORTIN-1 AND LIPOCORTIN-5
BECHERUCCI C, PERRETTI M, GALEOTTI CL
Mediat Inflamm vol. 2 (2), 109-113.  
01-04-1993
A novel way to get out of the cell.
Rubartelli A, Bajetto A, Bonifaci N, Di Blas E
Cytotechnology vol. 11 Suppl 1, S37-S40.  
01-01-1993
Studies on the induction of lipocortin-1 by glucocorticoids.
Solito E, De Caterina R, Giannessi D, Paggiaro PL, Sicari R, Parente L
Ann Ist Super Sanita vol. 29 (3), 391-394.  
01-01-1993
Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5.
Becherucci C, Perretti M, Solito E, Galeotti CL, Parente L
Mediators Inflamm vol. 2 (2), 109-113.  
01-01-1993
A NOVEL WAY TO GET OUT OF THE CELL
RUBARTELLI A, BAJETTO A, BONIFACI N, SITIA R
 
01-01-1993

1992

Mechanisms of IL-1 different biological activities. Studies using IL-1 muteins and IL-1 receptor antibodies
Parente L, Ghiara P, Melli M, Mugridge KG
Pharmacological Research, Elsevier vol. 26 
01-09-1992
Inhibition of eicosanoid formation and lipocortin induction by glucocorticoids in human cell lines and in patients with inflammatory lung disease.
Parente L, Solito E, Giannessi P, Paggiari P
Pharmacol Res vol. 26 Suppl 2, 44-45.  
01-09-1992
Induction of synthesis of lipocortin-I and inhibition of eicosanoid production in inflammatory cells: Evidence for a cell selectivity in glucocorticoid action
de Caterina R, Sicari R, Giannessi D, Paggiaro PL, Paoletti P, Lazzerini G, Parente L
Thrombosis Research, Elsevier vol. 65 
01-01-1992
Glucocorticoid effect on lipocortin mRNA expression in U-937 cells.
Solito E, Raugei G, Parente L
Pharmacol Res vol. 25 Suppl 1, 13-14.  
01-01-1992
Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice.
Perretti M, Solito E, Parente L
Agents Actions vol. 35 (1-2), 71-78.  
01-01-1992

1991

Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells.
Solito E, Raugei G, Melli M, Parente L
Febs Lett vol. 291 (2), 238-244.  
21-10-1991
DEXAMETHASONE INDUCES THE EXPRESSION OF THE MESSENGER-RNA OF LIPOCORTIN-1 AND LIPOCORTIN-2 AND THE RELEASE OF LIPOCORTIN-1 AND LIPOCORTIN-5 IN DIFFERENTIATED, BUT NOT UNDIFFERENTIATED U-937 CELLS
SOLITO E, RAUGEI G, PARENTE L
Febs Lett vol. 291 (2), 238-244.  
21-10-1991
A novel anti-inflammatory peptide from human lipocortin 5.
Perretti M, Becherucci C, Mugridge KG, Solito E, Silvestri S, Parente L
Br J Pharmacol vol. 103 (2), 1327-1332.  
01-06-1991
Effect of dexamethasone and phorbol myristate acetate on lipocortin 1, 2 and 5 mRNA and protein synthesis.
Solito E, Raugei G, Melli M
Adv Prostaglandin Thromboxane Leukot Res vol. 21A, 291-294.  
01-01-1991
Mechanism of acute toxicity of IL-1 beta in mice.
Boraschi D, Villa L, Ghiara P, Tagliabue A, Mengozzi M, Solito E, Parente L, Silvestri S et al.
Eur Cytokine Netw vol. 2 (1), 61-67.  
01-01-1991
EFFECT OF DEXAMETHASONE AND PHORBOL-MYRISTATE ACETATE ON LIPOCORTIN-1, LIPOCORTIN-2 AND LIPOCORTIN-5 MESSENGER-RNA AND PROTEIN-SYNTHESIS
SOLITO E, RAUGEI G, MELLI M, SAMUELSSON B, RAMWELL PW, PAOLETTI R, FOLCO G, GRANSTROM E
 
01-01-1991

1990

In vitro and in vivo activation of phospholipase A2 by interleukin-1
Parente L, Mugridge KG, Perretti M, Solito E
Pharmacological Research, Elsevier vol. 22 
01-09-1990
Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids?
Parente L, Becherucci C, Perretti M, Solito E, Mugridge KG, Galeotti CL, Raugei G, Melli M et al.
Prog Clin Biol Res vol. 349, 55-68.  
01-01-1990
Purification and biological activity of human lipocortin 2.
Becherucci C, Solito E, Perretti M, Mugridge KG, Galeotti CL, Parente L
Pharmacol Res vol. 22 Suppl 1, 29-30.  
01-01-1990

1989

Modulation of phospholipase A2 activity in human fibroblasts.
Solito E, Parente L
Br J Pharmacol vol. 96 (3), 656-660.  
01-03-1989

1988

ACTIVATION OF PHOSPHOLIPASE-A2 BY INTERLEUKIN-1 IN HUMAN-FIBROBLASTS
SOLITO E, PARENTE L
Lymphokine Res vol. 7 (3), 261-261.  
01-01-1988

1985

[Relational perspective in a district service for the substance-dependent].
Solito E, Busoni P
Minerva Psichiatr vol. 26 (3), 267-269.  
01-01-1985

Metabolic dysfunction over a life course key to healthy ageing inequality
Littlewood K, Gegic J, Hickman M, Henson R, Bishop J, Kershaw T, Diamond P, Slabaugh G et al.
Aging Clinical and Experimental Research, Springer 
The resolution of acute inflammation induced by cyclic AMP is dependent on Annexin A1
SOLITO E
Journal of Biological Chemistry, American Society For Biochemistry and Molecular Biology 
Treatment with Annexin A1 attenuates the development of diabetic nephropathy and cardiomyopathy, in murine type 1 diabetes, through restoration of AKT signalling.

Diabetologia, Springer Verlag 
Identification of AnnexinA1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes.

Frontiers in Immunology, Frontiers Media 


 
Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier
Solito E
Journal of Neuroinflammation, Biomed Central 


 
Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues

The Faseb Journal, Federation of American Society of Experimental Biology 
Mitochondrial mass governs the extent of T cell senescence

In Biorxiv 
Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide
Hoyles L, Pontifex MG, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S et al.
In Biorxiv 
Estrogen promotes pro-resolving microglial behaviour and phagocytic cell clearance through the actions of annexin A1
Loiola RA, Wickstead ES, Solito E, McArthur S
In Biorxiv 
Cerebrovascular damage caused by the gut microbe/host co-metabolite p-cresol sulfate is prevented by blockade of the EGF receptor

In Biorxiv 
The Glucose Transporter 2 regulates CD8+ T cell function via environment sensing
Fu H, Vuononvirta J, Fanti S, Bonacina F, D’Amati A, Wang G, Poobalasingam T, Fankhaenel M et al.
Nature Metabolism, Nature Research 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconPhD support to Anna Poliniewicz
Egle Solito
£6,000 WHRF William Harvey Research Foundation
01-10-2021 - 30-09-2022
bullet iconBBI immunometabolic aging
Egle Solito
£10,505 William Harvey Research Limited
01-05-2019 - 31-12-2023
bullet iconBHF : 4 Year PhD Studentship Award - 4th Intake
Egle Solito
£36,000 BHF British Heart Foundation
01-10-2016 - 30-09-2021
bullet iconInvestigating BBB and periopheral inflammation- TMTL1A8R- EXTENSION!
Egle Solito
£40,556 WHRL William Harvey Research Limited
01-06-2014 - 31-12-2019