Research

Blood-Brain Barrier (BBB), Immunobiology, Inflammation, Cerebrovascular Dementia, Ageing, Metabolism

Infectious Disease and Inflammation Models, Neuronal Models

Interests

Publications

Publications of specific relevance to Predictive in vitro Models

2022

(2022). Impact of metabolic disorders on the structural, functional, and immunological integrity of the blood-brain barrier: Therapeutic avenues. Faseb Journal  vol. 36, (1) 10.1096/fj.202101297R

2021

Hoyles L, Pontifex MG, Rodriguez-Ramiro I, Anis-Alavi MA, Jelane KS, Snelling T, Solito E, Fonseca S, Carvalho AL, Carding SR, Müller M, Glen RC, Vauzour D and McArthur S (2021). Regulation of blood–brain barrier integrity by microbiome-associated methylamines and cognition by trimethylamine N-oxide. Microbiome  vol. 9, (1) 10.1186/s40168-021-01181-z

Chee SEJ and Solito E (2021). The Impact of Ageing on the CNS Immune Response in Alzheimer’s Disease. Frontiers in Immunology  vol. 12, 10.3389/fimmu.2021.738511

Mohammad S, Zoubi SA, Collotta D, Krieg N, Wissuwa B, Alves GF, Purvis GSD, Norata GD, Baragetti A, Catapano AL, Solito E, Zechendorf E, Schürholz T, Correa-Vargas W, Brandenburg K, Coldewey SM, Collino M, Yaqoob MM, Martin L and Thiemermann C (2021). A Synthetic Peptide Designed to Neutralize Lipopolysaccharides Attenuates Metaflammation and Diet-Induced Metabolic Derangements in Mice. Frontiers in Immunology  vol. 12, 701275-701275. 10.3389/fimmu.2021.701275

(2021). Annexin-A1 restores cerebrovascular integrity concomitant with reduced amyloid-β and tau pathology. Oxford University Press (Oup)  Brain: a Journal of Neurology  10.1093/brain/awab050

2020

Solito E, Marelli-Berg F, Fanti S, Cheung K, Mauro C, Wang G, Nair A, Fu H, Angeletti S, Spoto S, Fogolari M, Romano F, Aksentijevic D, Liu W, Li B, Cheng L, YANG LW, Juho V, Thanushiyan P, Smith D and Ciccozzi M (2020). Preservation of microvascular barrier function requires CD31 receptor-induced metabolic reprogramming. Nature Research (Part of Springer Nature)  Nature Communications  vol. 11, 10.1038/s41467-020-17329-8

Majkowska A, Redondo-Gómez C, Rice A, Gonzalez M, Inostroza-Brito KE, Collin EC, Rodriguez-Cabello JC, Del Rio Hernandez AE, Solito E and Mata A (2020). Interfacial Self-Assembly to Spatially Organize Graphene Oxide Into Hierarchical and Bioactive Structures. Frontiers in Materials  vol. 7, 10.3389/fmats.2020.00167

Sheikh MH, Henson S, Loiola RA, Mercurio S, Colamatteo A, Maniscalco GT, De Rosa V, Mcarthur S and Solito E (2020). Immuno-metabolic impact of the multiple sclerosis patients’ sera on endothelial cells of the blood-brain barrier. Biomed Central  Journal of Neuroinflammation  10.1186/s12974-020-01810-8

2019

Callender L, Carroll E, BOBER E, Akbar A, Solito E and Henson S (2019). Mitochondrial mass governs the extent of human T cell senescence. John Wiley & Sons Ltd  Aging Cell  vol. 19, (2) 10.1111/acel.13067

Solito E, Montague-Cardoso K, Pitcher T, Chisolm K, Salera G, Lindstrom E, Hewitt E and Malcangio M (2019). Changes in vascular permeability in the spinal cord contribute to chemotherapy- induced neuropathic pain. Elsevier  Brain Behaviour and Immunity  10.1016/j.bbi.2019.10.018

Solito E, Zub E, Canet G, Garbelli R, Blaquiere M, Rossini L, Pastori C, Sheikh M, Reutelingsperger C, Klement W, de Bock F, Audinat E, Givalois L and Marchi N (2019). The GR-ANXA1 pathway is a pathological player and a candidate target in epilepsy., Editors: Weksler B. Federation of American Society of Experimental Biology  The Faseb Journal  10.1096/fj.201901596R

Solito E, Colamatteo A, Maggioli E, Azevedo Loiola R, Sheikh M, Cali G, Bruzzese D, Maniscalco T, Centonze D, Buttari F, Lanzillo R, Perna F, Zuccarelli B, Mottola M, Cassano S, Galgani M and De Rosa V (2019). Reduced Annexin A1 expression associates with disease severity and inflammation in multiple sclerosis patients. American Association of Immunologists  Journal of Immunology  10.4049/jimmunol.1801683

da Rocha GHO, Loiola RA, Pantaleão LDN, Reutelingsperger C, Solito E and Farsky SHP (2019). Control of expression and activity of peroxisome proliferated-activated receptor γ by Annexin A1 on microglia during efferocytosis. Wiley  Cell Biochemistry and Function  10.1002/cbf.3433

Loiola RA, Wickstead ES, Solito E and Mcarthur S (2019). Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance Through the Actions of Annexin A1. Frontiers Media  Frontiers in Endocrinology  10.3389/fendo.2019.00420

SOLITO EGLE, PURVIS G and THIEMERMANN C (2019). Annexin-A1: therapeutic potential in microvascular disease. Frontiers Media  Frontiers in Immunology  10.3389/fimmu.2019.00938

Purvis GSD, Collino M, Loiola RA, Baragetti A, Chiazza F, Brovelli M, Sheikh MH, Collotta D, Cento A, Mastrocola R, Aragno M, Cutrin JC, Reutelingsperger C, Grigore L, Catapano AL, Yaqoob MM, Norata GD, Solito E and Thiemermann C (2019). Identification of Annexina1 as an endogenous regulator of RhoA, and its role in the pathophysiology and experimental therapy of type-2 diabetes. Frontiers in Immunology  vol. 10, (MAR) 10.3389/fimmu.2019.00571

Loiola RA, Wickstead ES, Solito E and McArthur S (2019). Estrogen Promotes Pro-resolving Microglial Behavior and Phagocytic Cell Clearance through the Actions of Annexin A1. Frontiers in Endocrinology  vol. 10, (JUN) 10.3389/fendo.2019.00420

2018

SOLITO E (2018). Connections of Annexin A1 and Translocator Protein-18 KDa on Toll Like Receptor Stimulated BV-2 Cells. Exp Cell Res.  10.1016/j.yexcr.2018.04.008

SOLITO E and SHEIKH M (2018). Annexin A1: Uncovering the Many Talents of an Old Protein. Mdpi Ag  International Journal of Molecular Sciences  vol. 19, 10.3390/ijms19041045

S. D. Purvis G and Solito E (2018). Is AnnexinA1 The Miracle Drug For Diabetes? Science Trends  10.31988/scitrends.8741

2017

Purvis GSD, Chiazza F, Chen J, Loiola RA, Martin L, Fountoulakis N, Gnudi L, Collino M, Thiemermann C and Solito E (2017). Annexin A1 attenuates microvascular complications through restoration of Akt signalling in a murine model of type 1 diabetes. Springer Verlag  Diabetologia  10.1007/s00125-017-4469-y

Lima KM, Vago JP, Caux TR, Negreiros-Lima GL, Sugimoto MA, Tavares LP, Arribada RG, Carmo AAF, Galvão I, Costa BRC, Soriani FM, Pinho V, Solito E, Perretti M, Teixeira MM and Sousa LP (2017). The resolution of acute inflammation induced by cyclic AMP is dependent on Annexin A1. Journal of Biological Chemistry  vol. 292, (33) 13758-13773. 10.1074/jbc.M117.800391

2016

McArthur S, Loiola RA, Maggioli E, Errede M, Virgintino D and SOLITO E (2016). The restorative role of annexin A1 at the blood–brain barrier. Biomed Central  Fluids and Barriers of The Cns  vol. 13, (17) 10.1186/s12987-016-0043-0

SOLITO E, Loiola R, Ries M, Shah U, Gentleamn S and Sastre M (2016). The anti-inflammatory Annexin A1 induces the clearance and degradation of the amyloid-β peptide. Biomed Central  Journal of Neuroinflammation  vol. 13, 10.1186/s12974-016-0692-6

Sinniah A, Yazid S, Perretti M, Solito E and Flower RJ (2016). The role of the Annexin-A1/FPR2 system in the regulation of mast cell degranulation provoked by compound 48/80 and in the inhibitory action of nedocromil. International Immunopharmacology  vol. 32, 87-95. 10.1016/j.intimp.2016.01.003

Maggioli E, McArthur S, Mauro C, Kieswich J, Kusters DHM, Reutelingsperger CPM, Yaqoob M and Solito E (2016). Estrogen protects the blood–brain barrier from inflammation-induced disruption and increased lymphocyte trafficking. Brain, Behavior, and Immunity  vol. 51, 212-222. 10.1016/j.bbi.2015.08.020

2015

Yazid S, Gardner PJ, Carvalho L, Chu CJ, Flower RJ, Solito E, Lee RWJ, Ali RR and Dick AD (2015). Annexin-A1 restricts Th17 cells and attenuates the severity of autoimmune disease. Journal of Autoimmunity  vol. 58, 1-11. 10.1016/j.jaut.2014.12.004

Mauro C, De Rosa V, Marelli-Berg F and Solito E (2015). Metabolic syndrome and the immunological affair with the blood-brain barrier. Frontiers in Immunology  vol. 6, (JAN) 10.3389/fimmu.2014.00677

2014

Queiroz CJDS, Nakata CMDAG, Solito E and Damazo AS (2014). Relationship between HPV and the biomarkers annexin A1 and p53 in oropharyngeal cancer. Infect Agent Cancer  vol. 9, 10.1186/1750-9378-9-13

dos Santos Queiroz CJ, de Amorim Gomes Nakata CM, Solito E and Damazo AS (2014). Head and Neck Pathology. Pathology  vol. 46, (&NA;) 10.1097/01.pat.0000454431.15263.c4

2013

Girol AP, Mimura KKO, Drewes CC, Bolonheis SM, Solito E, Farsky SHP, Gil CD and Oliani SM (2013). Anti-inflammatory mechanisms of the annexin A1 protein and its mimetic peptide Ac2-26 in models of ocular inflammation in vivo and in vitro. J Immunol  vol. 190, (11) 5689-5701. 10.4049/jimmunol.1202030

Cristante E, McArthur S, Mauro C, Maggioli E, Romero IA, Wylezinska-Arridge M, Couraud PO, Lopez-Tremoleda J, Christian HC, Weksler BB, Malaspina A and Solito E (2013). Identification of an essential endogenous regulator of blood-brain barrier integrity, and its pathological and therapeutic implications. Proc Natl Acad Sci U S A  vol. 110, (3) 832-841. 10.1073/pnas.1209362110

Yazid S, Sinniah A, Solito E, Calder V and Flower RJ (2013). Anti-allergic cromones inhibit histamine and eicosanoid release from activated human and murine mast cells by releasing Annexin A1. Plos One  vol. 8, (3) 10.1371/journal.pone.0058963

2012

Mehet DK, Philip J, Solito E, Buckingham JC and John CD (2012). Evidence from in vitro and in vivo studies showing that nuclear factor-κB within the pituitary folliculostellate cells and corticotrophs regulates adrenocorticotrophic hormone secretion in experimental endotoxaemia. J Neuroendocrinol  vol. 24, (6) 862-873. 10.1111/j.1365-2826.2012.02285.x

Solito E and Sastre M (2012). Microglia function in Alzheimer's disease. Front Pharmacol  vol. 3, 10.3389/fphar.2012.00014

2010

McArthur S, Cristante E, Paterno M, Christian H, Roncaroli F, Gillies GE and Solito E (2010). Annexin A1: a central player in the anti-inflammatory and neuroprotective role of microglia. J Immunol  vol. 185, (10) 6317-6328. 10.4049/jimmunol.1001095

Yazid S, Leoni G, Getting SJ, Cooper D, Solito E, Perretti M and Flower RJ (2010). Antiallergic cromones inhibit neutrophil recruitment onto vascular endothelium via annexin-A1 mobilization. Arterioscler Thromb Vasc Biol  vol. 30, (9) 1718-1724. 10.1161/ATVBAHA.110.209536

Yazid S, Ayoub SS, Solito E, McArthur S, Vo P, Dufton N and Flower RJ (2010). Anti-allergic drugs and the Annexin-A1 system. Pharmacol Rep  vol. 62, (3) 511-517. 10.1016/s1734-1140(10)70307-8

2009

McArthur S, Yazid S, Christian H, Sirha R, Flower R, Buckingham J and Solito E (2009). Annexin A1 regulates hormone exocytosis through a mechanism involving actin reorganization. Faseb J  vol. 23, (11) 4000-4010. 10.1096/fj.09-131391

Yazid S, Solito E, Christian H, McArthur S, Goulding N and Flower R (2009). Cromoglycate drugs suppress eicosanoid generation in U937 cells by promoting the release of Anx-A1. Biochem Pharmacol  vol. 77, (12) 1814-1826. 10.1016/j.bcp.2009.03.010

2008

Yazid S, Solito E, Christian H, Goulding N and Flower R (2008). Further studies on the rapid glucocorticoid effects in the U937 monocytic cell line and its potentiation by cromoglycate-like drugs. Fund Clin Pharmacol  vol. 22, 47-47.

McArthur S, Prasongchean W, Gillies G and Solito E (2008). A critical role for the anti-inflammatory protein annexin A1 in microglial phagocytosis. Fund Clin Pharmacol  vol. 22, 23-23.

Damazo AS, Flower RJ, Solito E and Oliani SM (2008). Annexin-A1 gene expression during liver development and post-translation modification after experimental endotoxemia. Inflamm Res  vol. 57, (3) 97-103. 10.1007/s00011-007-7114-2

Hu NJ, Bradshaw J, Lauter H, Buckingham J, Solito E and Hofmann A (2008). Membrane-induced folding and structure of membrane-bound annexin A1 N-terminal peptides: Implications for annexin-induced membrane aggregation. Biophys J  vol. 94, (5) 1773-1781. 10.1529/biophysj.107.119685

Solito E, McArthur S, Christian H, Gavins F, Buckingham JC and Gillies GE (2008). Annexin A1 in the brain--undiscovered roles? Trends Pharmacol Sci  vol. 29, (3) 135-142. 10.1016/j.tips.2007.12.003

2007

John CD, Sahni V, Mehet D, Morris JF, Christian HC, Perretti M, Flower RJ, Solito E and Buckingham JC (2007). Formyl peptide receptors and the regulation of ACTH secretion: targets for annexin A1, lipoxins, and bacterial peptides. Faseb J  vol. 21, (4) 1037-1046. 10.1096/fj.06-7299com

2006

Warne JP, John CD, Christian HC, Morris JF, Flower RJ, Sugden D, Solito E, Gillies GE and Buckingham JC (2006). Gene deletion reveals roles for annexin A1 in the regulation of lipolysis and IL-6 release in epididymal adipose tissue. Am J Physiol-Endoc M  vol. 291, (6) E1264-E1273. 10.1152/ajpendo.00655.2005

Kamal AM, Hayhoe RPG, Paramasivam A, Cooper D, Flower RJ, Solito E and Perretti M (2006). Antiflammin-2 activates the human formyl-peptide receptor like 1. Scientificworldjournal  vol. 6, 1375-1384. 10.1100/tsw.2006.247

Buckingham J, John C, Solito E, Flower R, Christian H and Morris J (2006). Annexin 1: a mediator of glucocorticoid action at the neuroendocrine-immune interface. Acta Pharmacol Sin  vol. 27, 1-1.

FLOWER RJ, Buckingham JC, Tierney T, Festa M, Christian HC, Solito E and Mulla A (2006). Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. Faseb J  vol. 20, (9) 1498-1500. 10.1096/fj.05-5319fje

Solito E, Christian HC, Festa M, Mulla A, Tierney T, Flower RJ and Buckingham JC (2006). Post-translational modification plays an essential role in the translocation of annexin A1 from the cytoplasm to the cell surface. Faseb J  vol. 20, (9) 1498-1500. 10.1096/fj.05-5319fje

Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E and Parente L (2006). Down-regulation of annexin-1 expression in thyroid cancers is associated with tumour aggressiveness. Acta Pharmacol Sin  vol. 27, 65-65.

Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E and Parente L (2006). Annexin-1 downregulation in thyroid cancer correlates to the degree of tumor differentiation. Cancer Biol Ther  vol. 5, (6) 643-647. 10.4161/cbt.5.6.2700

Rodrigues-Lisoni FC, Mehet DK, Peitl P, John CD, da Silva WA, Tajara E, Buckingham JC and Solito E (2006). In vitro and in vivo studies on CCR10 regulation by Annexin A1 (vol 580, pg 1431, 2006). Febs Lett  vol. 580, (7) 1908-1908. 10.1016/j.febslet.2006.02.026

Hayhoe RPG, Kamal AM, Solito E, Flower RJ, Cooper D and Perretti M (2006). Annexin 1 and its bioactive peptide inhibit neutrophil-endothelium interactions under flow: indication of distinct receptor involvement. Blood  vol. 107, (5) 2123-2130. 10.1182/blood-2005-08-3099

Rodrigues-Lisoni FC, Mehet DK, Peitl P, John CD, da Silva Júnior WA, Tajara E, Buckingham JC and Solito E (2006). In vitro and in vivo studies on CCR10 regulation by Annexin A1. Febs Lett  vol. 580, (5) 1431-1438. 10.1016/j.febslet.2006.01.072

2005

Petrella A, Festa M, Ercolino SF, Zerilli M, Stassi G, Solito E and Parente L (2005). Induction of annexin-1 during TRAIL-induced apoptosis in thyroid carcinoma cells. Cell Death Differ  vol. 12, (10) 1358-1360. 10.1038/sj.cdd.4401645

Rodrigues-Lisoni FC, Oliani S, Buckingham J, Solito E and Tajara EH (2005). Annexin A1: From gene organization to physiology. Annexins  vol. 2, (2)

Mulla A, Leroux C, Solito E and Buckingham JC (2005). Correlation between the antiinflammatory protein annexin 1 (lipocortin 1) and serum cortisol in subjects with normal and dysregulated adrenal function. J Clin Endocrinol Metab  vol. 90, (1) 557-562. 10.1210/jc.2004-1230

2004

Perretti M and Solito E (2004). Annexin 1 and neutrophil apoptosis. Biochemical Society Transactions  vol. 32, 507-510. 10.1042/BST0320507

John CD, Christian HC, Morris JF, Flower RJ, Solito E and Buckingham JC (2004). Annexin 1 and the regulation of endocrine function. Trends Endocrin Met  vol. 15, (3) 103-109. 10.1016/j.tem.2004.02.001

Parente L and Solito E (2004). Annexin 1: more than an anti-phospholipase protein. Inflamm Res  vol. 53, (4) 125-132. 10.1007/s00011-003-1235-z

Mulla A, Christian HC, Solito E, Mendoza N, Morris JF and Buckingham JC (2004). Expression, subcellular localization and phosphorylation status of annexins 1 and 5 in human pituitary adenomas and a growth hormone-secreting carcinoma. Clin Endocrinol (Oxf)  vol. 60, (1) 107-119. 10.1111/j.1365-2265.2004.01936.x

2003

Tierney T, Christian HC, Morris JF, Solito E and Buckingham JC (2003). Evidence from studies on co-cultures of TtT/GF and AtT20 cells that Annexin 1 acts as a paracrine or juxtacrine mediator of the early inhibitory effects of glucocorticoids on ACTH release. J Neuroendocrinol  vol. 15, (12) 1134-1143. 10.1111/j.1365-2826.2003.01111.x

John CD, Christian HC, Morris JF, Flower RJ, Solito E and Buckingham JC (2003). Kinase-dependent regulation of the secretion of thyrotrophin and luteinizing hormone by glucocorticoids and annexin 1 peptides. J Neuroendocrinol  vol. 15, (10) 946-957. 10.1046/j.1365-2826.2003.01081.x

de Coupade C, Solito E and Levine JD (2003). Dexamethasone enhances interaction of endogenous annexin 1 with L-selectin and triggers shedding of L-selectin in the monocytic cell line U-937. Br J Pharmacol  vol. 140, (1) 133-145. 10.1038/sj.bjp.0705413

Buckingham JC, Solito E, John C, Tierney T, Taylor A, Flower R, Christian H and Morris J (2003). Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system. Cell Biochem Funct  vol. 21, (3) 217-221. 10.1002/cbf.1076

Solito E, Kamal A, Russo-Marie F, Buckingham JC, Marullo S and Perretti M (2003). A novel calcium-dependent proapoptotic effect of annexin 1 on human neutrophils. Faseb J  vol. 17, (9) 1544-+. 10.1096/fj.02-0941fje

Croxtall JD, Gilroy DW, Solito E, Choudhury Q, Ward BJ, Buckingham JC and Flower RJ (2003). Attenuation of glucocorticoid functions in an Anx-A1-/- cell line. Biochem J  vol. 371, (Pt 3) 927-935. 10.1042/BJ20021856

Solito E, Mulla A, Morris JF, Christian HC, Flower RJ and Buckingham JC (2003). Dexamethasone induces rapid serine-phosphorylation and membrane translocation of annexin 1 in a human folliculostellate cell line via a novel nongenomic mechanism involving the glucocorticoid receptor, protein kinase c, phosphatidylinositol 3-kinase, and mitogen-activated protein kinase. Endocrinology  vol. 144, (4) 1164-1174. 10.1210/en.2002-220592

FLOWER RJ, John C, Solito E, Morris J, Tierney T, Taylor A, Christian H and Buckingham JC (2003). Annexin 1: a paracrine/juxtacrine mediator of glucorticoid action in the neuroendocrine system. Cell Biochemistry and Function.  vol. 21, (3) 217-221. 10.1002/cbf.1076

FLOWER RJ, Morris JF, Christian HC, Buckingham JC, Solito E and John CD (2003). Kinase-Dependent Regulation of the Secretion of Thyrotrophin and Luteinizing Hormone By Glucocorticoids and Annexin 1 Peptides. J Neuroendocrinol.  vol. 15, (10) 946-957. 10.1046/j.1365-2826.2003.01081.x

2002

Perretti M, Chiang N, La M, Fierro IM, Marullo S, Getting SJ, Solito E and Serhan CN (2002). Endogenous lipid- and peptide-derived anti-inflammatory pathways generated with glucocorticoid and aspirin treatment activate the lipoxin A4 receptor. Nat Med  vol. 8, (11) 1296-1302. 10.1038/nm786

Perretti M, Ingegnoli F, Wheller SK, Blades MC, Solito E and Pitzalis C (2002). Annexin 1 modulates monocyte-endothelial cell interaction in vitro and cell migration in vivo in the human SCID mouse transplantation model. J Immunol  vol. 169, (4) 2085-2092. 10.4049/jimmunol.169.4.2085

Mulla A, Buckingham JC and Solito E (2002). LPS acts via IL-6 and IL-1 to modulate the expression and phosphorylation of annexin 1 in cell lines derived from the putative microglia of the neuroendocrine system. Brit J Pharmacol  vol. 135,

Solito E, Mulla A and Buckingham JC (2002). Dexamethasone induces serine phosphorylation of annexin 1: Involvement of PKC and PI3-kinase. Brit J Pharmacol  vol. 135,

Solito E, Mulla A, Flower RJ and Buckingham JC (2002). Lipocortin 1 (Annexin 1). Wiley Encyclopedia of Molecular Medicine  10.1002/0471203076.emm1088

FLOWER RJ, Buckingham J, Christian H, Solito E, John C, Cover P and Morris J (2002). Annexin 1-dependent actions of glucocorticoids in the anterior pituitary gland: roles of the N-terminal domain and protein kinase C. Endocrinology.  vol. 143, (8) 3060-3070. 10.1210/endo.143.8.8965

2001

de Coupade C, Ajuebor MN, Russo-Marie F, Perretti M and Solito E (2001). Cytokine modulation of liver annexin 1 expression during experimental endotoxemia. Am J Pathol  vol. 159, (4) 1435-1443. 10.1016/S0002-9440(10)62530-8

Kamal AM, Smith SF, De Silva Wijayasinghe M, Solito E and Corrigan CJ (2001). An annexin 1 (ANXA1)-derived peptide inhibits prototype antigen-driven human T cell Th1 and Th2 responses in vitro. Clin Exp Allergy  vol. 31, (7) 1116-1125. 10.1046/j.1365-2222.2001.01137.x

Perretti M, Getting SJ, Solito E, Murphy PM and Gao JL (2001). Involvement of the receptor for formylated peptides in the in vivo anti-migratory actions of annexin 1 and its mimetics. Am J Pathol  vol. 158, (6) 1969-1973. 10.1016/S0002-9440(10)64667-6

John CD, Solito E, Mulla A, Morris JF, Flower RJ and Buckingham JC (2001). Dexamethasone induces serine phosphorylation of annexin 1 in pituitary cells and suppresses ACTH release by a PKC-dependent mechanism. Brit J Pharmacol  vol. 133, U20-U20.

Solito E, de Coupade C, Canaider S, Goulding NJ and Perretti M (2001). Transfection of annexin 1 in monocytic cells produces a high degree of spontaneous and stimulated apoptosis associated with caspase-3 activation. Brit J Pharmacol  vol. 133, (2) 217-228. 10.1038/sj.bjp.0704054

2000

Solito E, Tissot M, Russo-Marie F and Marullo S (2000). Extracellular annexin-1 accelerates apoptosis of human polymorphonuclears neutrophils. Mol Biol Cell  vol. 11, 462A-463A.

(2000). Lipocortin 1 reduces myocardial ischemia-reperfusion injury by affecting local leukocyte recruitment. Faseb J  vol. 14, (13) 1867-1869. 10.1096/fj.99-0602fje

Solito E, Romero IA, Marullo S, Russo-Marie F and Weksler BB (2000). Annexin 1 binds to U937 monocytic cells and inhibits their adhesion to microvascular endothelium: involvement of the alpha 4 beta 1 integrin. J Immunol  vol. 165, (3) 1573-1581. 10.4049/jimmunol.165.3.1573

Mulla A, Christian H, Morris J, Mendoza N, Solito E and Buckingham J (2000). Expression of annexins 1 and 5 in human pituitary tumours. J Physiol-London  vol. 525, 53P-54P.

Solito E, Tissot M, Russo-Marie F and Marullo S (2000). Extracellular Annexin 1 induces apoptosis of human polymorphonuclear neutrophils. Faseb J  vol. 14, (8) A1357-A1357.

Le Maire V, Solito E, Russo-Marie F, Hernvann A, Le Marechal H, Ekindjian OG and Aussel C (2000). System A neutral amino acid transporter regulation by interleukin-1beta in human osteoarthritic synovial cells: evidence for involvement of prostaglandin E(2) as a second messenger. J Cell Physiol  vol. 183, (1) 65-73. 10.1002/(SICI)1097-4652(200004)183:1<65::AID-JCP8>3.0.CO;2-H

Canaider S, Solito E, de Coupade C, Flower RJ, Russo-Marie F, Goulding NJ and Perretti M (2000). Increased apoptosis in U937 cells over-expressing lipocortin 1 (annexin I). Life Sci  vol. 66, (18) PL265-PL270. 10.1016/s0024-3205(00)00500-2

(2000). Annexin 1 activates human neutrophils: A mechanism for its anti-inflammatory in vivo effect. Faseb J  vol. 14, (4) A8-A8.

de Coupade C, Gillet R, Bennoun M, Briand P, Russo-Marie F and Solito E (2000). Annexin 1 expression and phosphorylation are upregulated during liver regeneration and transformation in antithrombin III SV40 T large antigen transgenic mice. Hepatology  vol. 31, (2) 371-380. 10.1002/hep.510310217

(2000). Lipocortin 1 inhibits myocardial infarct by reducing local neutrophil infiltration. Brit J Pharmacol  vol. 129, U56-U56.

1999

Gidon-Jeangirard C, Solito E, Hofmann A, Russo-Marie F, Freyssinet JM and Martínez MC (1999). Annexin V counteracts apoptosis while inducing Ca(2+) influx in human lymphocytic T cells. Biochem Biophys Res Commun  vol. 265, (3) 709-715. 10.1006/bbrc.1999.1752

Young KA, Hirst WD, Solito E and Wilkin GP (1999). De novo expression of lipocortin-1 in reactive microglia and astrocytes in kainic acid lesioned rat cerebellum. Glia  vol. 26, (4) 333-343. 10.1002/(sici)1098-1136(199906)26:4<333::aid-glia7>3.0.co;2-s

Canaider S, Solito E, Goulding NJ, Flower RJ and Perretti M (1999). Increased apoptosis in cells overexpressing lipocortin 1. Brit J Pharmacol  vol. 126, U26-U26.

John CD, Cover PO, Taylor AD, Morris JF, Flower RJ, Solito E and Buckingham JC (1999). Evidence from in vivo and in vitro studies that the inhibitory actions of lipocortin 1 on anterior pituitary function require amino acid residues 13-26. Brit J Pharmacol  vol. 126, U74-U74.

Raguenes-Nicol C, Russo-Marie F, Domage G, Diab N, Solito E, Dray F, Mace JL and Streichenberger G (1999). Anti-inflammatory mechanism of alminoprofen: action on the phospholipid metabolism pathway. Biochem Pharmacol  vol. 57, (4) 433-443. 10.1016/s0006-2952(98)00312-8

(1999). Preferential accumulation of muscle type acylphosphatase in the nucleus during differentiation. Biochem Mol Biol Int  vol. 47, (1) 127-136. 10.1080/15216549900201123

1998

Lim LH, Solito E, Russo-Marie F, Flower RJ and Perretti M (1998). Promoting detachment of neutrophils adherent to murine postcapillary venules to control inflammation: effect of lipocortin 1. Proc Natl Acad Sci U S A  vol. 95, (24) 14535-14539. 10.1073/pnas.95.24.14535

Solito E, Raguenes-Nicol C, de Coupade C, Bisagni-Faure A and Russo-Marie F (1998). U937 cells deprived of endogenous annexin 1 demonstrate an increased PLA2 activity. Br J Pharmacol  vol. 124, (8) 1675-1683. 10.1038/sj.bjp.0701991

Solito E, de Coupade C, Parente L, Flower RJ and Russo-Marie F (1998). IL-6 stimulates annexin 1 expression and translocation and suggests a new biological role as class II acute phase protein. Cytokine  vol. 10, (7) 514-521. 10.1006/cyto.1997.0325

Solito E, de Coupade C, Parente L, Flower RJ and Russo-Marie F (1998). Human annexin 1 is highly expressed during the differentiation of the epithelial cell line A 549: involvement of nuclear factor interleukin 6 in phorbol ester induction of annexin 1. Cell Growth Differ  vol. 9, (4) 327-336.

Dubois T, Mira JP, Feliers D, Solito E, Russo-Marie F and Oudinet JP (1998). Annexin V inhibits protein kinase C activity via a mechanism of phospholipid sequestration. Biochem J  vol. 330 ( Pt 3), 1277-1282. 10.1042/bj3301277

1997

Lim LHK, Getting SJ, Das AM, Solito E, Flower RJ and Perretti M (1997). Inhibition of neutrophil : endothelium interaction in murine post-capillary venules by lipocortin 1. Brit J Pharmacol  vol. 122, U54-U54.

Voermans PH, Go KG, Horst GJT, Ruiters MHJ, Solito E and Parente L (1997). P-3-325 Steroid-induced expression of annexinin brain. Clinical Neurology and Neurosurgery  vol. 99, s145-s146. 10.1016/s0303-8467(97)81931-2

Voermans PH, Go KG, ter Horst GJ, Ruiters MHJ, Solito E and Parente L (1997). Expression of Annexin and Annexin-mRNA in Rat Brain Under Influence of Steroid Drugs. Brain Edema X  10.1007/978-3-7091-6837-0_68

Voermans PH, Go KG, ter Horst GJ, Ruiters MH, Solito E and Parente L (1997). Expression of annexin and annexin-mRNA in rat brain under influence of steroid drugs. Acta Neurochir Suppl  vol. 70, 222-224. 10.1007/978-3-7091-6837-0_68

1996

Cifone MG, Cironi L, Roncaioli P, Martinotti S, Toniato E, Cilenti L, Botti D, Solito E, Parente L and Santoni A (1996). Phospholipase A(2) activity and calpactin I levels in rat lymphokine-activated killer cells: Correlation with the cytotoxic activity. Cell Immunol  vol. 170, (2) 274-282. 10.1006/cimm.1996.0161

Ambrosetti DC, Palla E, Mirtella A, Galeotti C, Solito E, Navarra P, Parente L and Melli M (1996). Synthetic alleles at position 121 define a functional domain of human interleukin-1 beta. Eur J Biochem  vol. 238, (2) 308-316. 10.1111/j.1432-1033.1996.0308z.x

Voermans PH, Go KG, Horst GJ, Ruiters MH, Solito E and Parente L (1996). Induction of annexin-1 at transcriptional and post-transcriptional level in rat brain by methylprednisolone and the 21-aminosteroid U74389F. Mediators Inflamm  vol. 5, (5) 370-378. 10.1155/S0962935196000531

1995

Parente L, Ambrosetti D, Palla E, Mirtella A, Galeotti CL, Solito E, Navarra P and Melli M (1995). A new functional binding site for interleukin-1beta? Pharmacological Research  vol. 31, 10.1016/1043-6618(95)87462-3

1994

Parente L and Solito E (1994). Association between glucocorticosteroids and lipocortin 1. Trends Pharmacol Sci  vol. 15, (10) 10.1016/0165-6147(94)90154-6

Solito E, Nuti S and Parente L (1994). Dexamethasone-induced translocation of lipocortin (annexin) 1 to the cell membrane of U-937 cells. Br J Pharmacol  vol. 112, (2) 347-348. 10.1111/j.1476-5381.1994.tb13075.x

Go KG, Zuiderveen F, De Ley L, Ter Haar JG, Parente L, Solito E and Molenaar WM (1994). Effect of steroids on brain lipocortin immunoreactivity. Acta Neurochir Suppl (Wien)  vol. 60, 101-103. 10.1007/978-3-7091-9334-1_26

Go KG, Ter Haar JG, de Ley L, Zuiderveen F, Parente L, Solito E and Molenaar WM (1994). The effect of steroid treatment on lipocortin immunoreactivity of rat brain. Mediators Inflamm  vol. 3, (3) 177-180. 10.1155/S0962935194000232

GO KG, ZUIDERVEEN F, DELEY L, TERHAAR JG, PARENTE L, SOLITO E and MOLENAAR WM (1994). EFFECT OF STEROIDS ON BRAIN LIPOCORTIN IMMUNOREACTIVITY. Acta Neurochir  101-103. 10.1007/978-3-7091-9334-1_26

PARENTE L, NUTI S and SOLITO E (1994). DEXAMETHASONE INDUCES THE TRANSLOCATION OF LIPOCORTIN-1 TO THE MEMBRANE OF HUMAN MONOCYTIC U-937 CELLS. Brit J Pharmacol  vol. 111, P72-P72.

SOLITO E, PALLA E, BENSI G, FASSINA G, MELLI M and PARENTE L (1994). IDENTIFICATION OF ACTIVE-SITES OF INTERLEUKIN-1-BETA BY LOOP SUBSTITUTION AND SITE-DIRECTED MUTAGENESIS. Brit J Pharmacol  vol. 111, P31-P31.

1993

De Caterina R, Sicari R, Giannessi D, Paggiaro PL, Paoletti P, Lazzerini G, Bernini W, Solito E and Parente L (1993). Macrophage-specific eicosanoid synthesis inhibition and lipocortin-1 induction by glucocorticoids. J Appl Physiol (1985)  vol. 75, (6) 2368-2375. 10.1152/jappl.1993.75.6.2368

Palla E, Bensi G, Solito E, Buonamassa DT, Fassina G, Raugei G, Spano F, Galeotti C, Mora M and Domenighini M (1993). Loop substitution as a tool to identify active sites of interleukin-1 beta. J Biol Chem  vol. 268, (18) 13486-13492. 10.1016/s0021-9258(19)38675-2

BECHERUCCI C, PERRETTI M, SOLITO E, GALEOTTI CL and PARENTE L (1993). CONCEIVABLE DIFFERENCE IN THE ANTIINFLAMMATORY MECHANISMS OF LIPOCORTIN-1 AND LIPOCORTIN-5. Mediat Inflamm  vol. 2, (2) 109-113. 10.1155/S0962935193000158

Rubartelli A, Bajetto A, Bonifaci N, Di Blas E, Solito E and Sitia R (1993). A novel way to get out of the cell. Cytotechnology  vol. 11 Suppl 1, S37-S40. 10.1007/BF00746049

Solito E, De Caterina R, Giannessi D, Paggiaro PL, Sicari R and Parente L (1993). Studies on the induction of lipocortin-1 by glucocorticoids. Ann Ist Super Sanita  vol. 29, (3) 391-394.

Becherucci C, Perretti M, Solito E, Galeotti CL and Parente L (1993). Conceivable difference in the anti-inflammatory mechanisms of lipocortins 1 and 5. Mediators Inflamm  vol. 2, (2) 109-113. 10.1155/S0962935193000158

1992

Parente L, Galeotti CL, Ghiara P, Melli M, Mugridge KG and Solito E (1992). Mechanisms of IL-1 different biological activities. Studies using IL-1 muteins and IL-1 receptor antibodies. Pharmacological Research  vol. 26, 10.1016/1043-6618(92)90961-a

Parente L, Solito E, Giannessi P, Paggiari P, Sicari R and De Caterina R (1992). Inhibition of eicosanoid formation and lipocortin induction by glucocorticoids in human cell lines and in patients with inflammatory lung disease. Pharmacol Res  vol. 26 Suppl 2, 44-45. 10.1016/1043-6618(92)90591-x

Solito E, Raugei G, Melli M and Parente L (1992). Glucocorticoid effect on lipocortin mRNA expression in U-937 cells. Pharmacol Res  vol. 25 Suppl 1, 13-14. 10.1016/1043-6618(92)90517-f

de Caterina R, Sicari R, Giannessi D, Paggiaro PL, Paoletti P, Lazzerini G, Bernini W, Solito E and Parente L (1992). Induction of synthesis of lipocortin-I and inhibition of eicosanoid production in inflammatory cells: Evidence for a cell selectivity in glucocorticoid action. Thrombosis Research  vol. 65, 10.1016/0049-3848(92)90684-3

Perretti M, Solito E and Parente L (1992). Evidence that endogenous interleukin-1 is involved in leukocyte migration in acute experimental inflammation in rats and mice. Agents Actions  vol. 35, (1-2) 71-78. 10.1007/BF01990954

1991

Solito E, Raugei G, Melli M and Parente L (1991). Dexamethasone induces the expression of the mRNA of lipocortin 1 and 2 and the release of lipocortin 1 and 5 in differentiated, but not undifferentiated U-937 cells. Febs Lett  vol. 291, (2) 238-244. 10.1016/0014-5793(91)81293-h

SOLITO E, RAUGEI G, MELLI M and PARENTE L (1991). DEXAMETHASONE INDUCES THE EXPRESSION OF THE MESSENGER-RNA OF LIPOCORTIN-1 AND LIPOCORTIN-2 AND THE RELEASE OF LIPOCORTIN-1 AND LIPOCORTIN-5 IN DIFFERENTIATED, BUT NOT UNDIFFERENTIATED U-937 CELLS. Febs Lett  vol. 291, (2) 238-244. 10.1016/0014-5793(91)81293-H

Perretti M, Becherucci C, Mugridge KG, Solito E, Silvestri S and Parente L (1991). A novel anti-inflammatory peptide from human lipocortin 5. Br J Pharmacol  vol. 103, (2) 1327-1332. 10.1111/j.1476-5381.1991.tb09788.x

Solito E, Raugei G, Melli M and Parente L (1991). Effect of dexamethasone and phorbol myristate acetate on lipocortin 1, 2 and 5 mRNA and protein synthesis. Adv Prostaglandin Thromboxane Leukot Res  vol. 21A, 291-294.

Boraschi D, Villa L, Ghiara P, Tagliabue A, Mengozzi M, Solito E, Parente L, Silvestri S, Van Damme J and Ghezzi P (1991). Mechanism of acute toxicity of IL-1 beta in mice. Eur Cytokine Netw  vol. 2, (1) 61-67.

SOLITO E, RAUGEI G, MELLI M and PARENTE L (1991). EFFECT OF DEXAMETHASONE AND PHORBOL-MYRISTATE ACETATE ON LIPOCORTIN-1, LIPOCORTIN-2 AND LIPOCORTIN-5 MESSENGER-RNA AND PROTEIN-SYNTHESIS. Adv Prostag Thromb L  vol. 21, 291-294.

1990

Becherucci C, Solito E, Perretti M, Mugridge KG, Galeotti CL and Parente L (1990). Purification and biological activity of human lipocortin 2. Pharmacol Res  vol. 22 Suppl 1, 29-30. 10.1016/1043-6618(90)90792-c

Parente L, Mugridge KG, Perretti M and Solito E (1990). In vitro and in vivo activation of phospholipase A2 by interleukin-1. Pharmacological Research  vol. 22, 10.1016/1043-6618(90)90413-8

Parente L, Becherucci C, Perretti M, Solito E, Mugridge KG, Galeotti CL, Raugei G, Melli M and Sanso M (1990). Are the lipocortins the second messengers of the anti-inflammatory action of glucocorticoids? Prog Clin Biol Res  vol. 349, 55-68.

1989

Solito E and Parente L (1989). Modulation of phospholipase A2 activity in human fibroblasts. Br J Pharmacol  vol. 96, (3) 656-660. 10.1111/j.1476-5381.1989.tb11865.x

1988

SOLITO E and PARENTE L (1988). ACTIVATION OF PHOSPHOLIPASE-A2 BY INTERLEUKIN-1 IN HUMAN-FIBROBLASTS. Lymphokine Res  vol. 7, (3) 261-261.

1985

Solito E, Busoni P and Bini L (1985). [Relational perspective in a district service for the substance-dependent]. Minerva Psichiatr  vol. 26, (3) 267-269.

Grants

Grants of specific relevance to Predictive in vitro Models

Exploring endogenous mediators regulating blood brain barrier functionality in Alzheimer's Disease
Solito E
£29,650 Alzheimer's Research UK (01-11-2013 - 31-10-2016)

Invetigating teh inflammatory effect on blood brainbarrier
Solito E
£420,000 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (01-05-2015 - 31-10-2016)

Aging effect at the blood brain barrier
Solito E
£22,000 Coordenação de Aperfeiçoamento de Pessoal de Nível Superior (01-02-2016 - 30-09-2016)

Unreveiling the role of Annexin A1 in Multiple Sclerosis: Identification of an endogenous factor decoding T cell breach of the blood brain barrier and immune tolerance
Solito E
EUR250,000 FISM-Fondazione Italian Sclerosi Multipla (01-03-2016 - 29-02-2016)