Dr Emilie Marhuenda
PDRA
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Cardiomyocyte, Mechanobiology, Heart Disease, Intercalated Discs, Cell-cell signaling, Mechanosensing
Publications
Publications of specific relevance to Predictive in vitro Models2023
Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM and Stroud MJ (2023). Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovascular Research vol. 119, (11) 2074-2088. 10.1093/cvr/cvad061Fromager B, Marhuenda E, Louis B, Bakalara N, Cambedouzou J and Cornu D (2023). Recent Advances in Electrospun Fibers for Biological Applications. Mdpi Macromol—a Journal of Macromolecular Research vol. 3, (3) 569-613. 10.3390/macromol30300332022
Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T and Krause S (2022). Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids. Elsevier Biosensors and Bioelectronics 10.1016/j.bios.2022.115024Marhuenda E, Iskratsch T and Xanthis I (2022). Crosstalk between cell-matrix and cell-cell signaling in cardiomyocyte mechanosensing. Elsevier Journal of Molecular and Cellular Cardiology vol. 173, 10.1016/j.yjmcc.2022.08.190Swiatlowska P, Sit B, Feng Z, Marhuenda E, Zhou X, Xiao Q, Shanahan C, Yu C-H and Iskratsch T (2022). Mechanoregulation of vascular smooth muscle cells phenotype in atherosclerosis. Elsevier Journal of Molecular and Cellular Cardiology vol. 173, 41-42. 10.1016/j.yjmcc.2022.08.083Marhuenda E, Pandey P, Xanthis I, O'Neill C and Iskratsch T (2022). The cardiomyocyte mechanical code – Mechanical imprinting of talin interactions regulate cardiomyocyte mechanosensing and function. Elsevier Journal of Molecular and Cellular Cardiology vol. 173, 10.1016/j.yjmcc.2022.08.197Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M, HUANG D, Junquiang H, Gondarenko S, Hone J, Gadegaard N and Palma M (2022). Regulation of Cardiomyocyte Adhesion and
Mechanosignalling Through Distinct Nanoscale Behaviour of
Integrin Ligands Mimicking Healthy or Fibrotic ECM. The Royal Society Philosophical Transactions of The Royal Society B: Biological Sciences 10.1098/rstb.2022.0021Sixto-López Y, Marhuenda E, García-Vazquez JB, Fragoso-Vazquez MJ, Rosales-Hernández MC, Zacarías-Lara O, Méndez-Luna D, Gómez-Vidal JA, Cornu D, Norbert B and Correa-Basurto J (2022). Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells. Cellular and Molecular Neurobiology vol. 42, (6) 1909-1920. 10.1007/s10571-021-01072-9Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T (2022). Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching. American Association For The Advancement of Science Science Advances 10.1126/sciadv.abm34712021
Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot JP, Duffau H, Dennis JW, Cornu D and Bakalara N (2021). Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing. Journal of Experimental and Clinical Cancer Research vol. 40, (1) 10.1186/s13046-021-01925-72020
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T (2020). Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching. 10.1101/2020.12.27.424498Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot J-P, Duffau H, Dennis J, Cornu D and Bakalara N (2020). Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing. 10.1101/2020.09.25.3137832019
Saleh A, Marhuenda E, Fabre C, Hassani Z, Weille JD, Boukhaddaoui H, Guelfi S, Maldonado IL, Hugnot J-P, Duffau H, Bauchet L, Cornu D and Bakalara N (2019). A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-β1 expression. Sci Rep vol. 9, (1) 10.1038/s41598-019-51108-w