Dr Emilie Marhuenda
PDRA
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
Cardiomyocyte, Mechanobiology, Heart Disease, Intercalated Discs, Cell-cell signaling, Mechanosensing
Publications
Publications of specific relevance to Predictive in vitro Models2024
Fromager B, Cambedouzou J, Marhuenda E, Iskratsch T, Pinault M, Bakalara N and Cornu D (2024). Tunable electrospun scaffolds of polyacrylonitrile loaded with carbon nanotubes: from synthesis to biological applications. Wiley Chembiochem 10.1002/cbic.202300768Di Cio S, Marhuenda E, Haddrick M and Gautrot JE (2024). Vascularised cardiac spheroids-on-a-chip for testing the toxicity of therapeutics. Springer Nature Scientific Reports vol. 14, (1) 10.1038/s41598-024-53678-wFaleeva M, Ahmad S, Theofilatos K, Lynham S, Watson G, Whitehead M, Marhuenda E, Iskratsch T, Cox S and Shanahan CM (2024). Sox9 Accelerates Vascular Ageing by Regulating Extracellular Matrix Composition and Stiffness. American Heart Association Circulation Research 10.1161/CIRCRESAHA.123.3233652023
Iskratsch T, Swiatlowska P, Tipping W, Marhuenda E, Severi P, Fomin V, Yang Z, Xiao Q, Graham D and Shanahan C (2023). Hypertensive pressure mechanosensing alone triggers lipid droplet accumulation and
transdifferentiation of vascular smooth muscle cells to foam cells. Wiley Open Access Advanced Science 10.1002/advs.202308686Fromager B, Marhuenda E, Louis B, Bakalara N, Cambedouzou J and Cornu D (2023). Recent Advances in Electrospun Fibers for Biological Applications. Mdpi Macromol—a Journal of Macromolecular Research vol. 3, (3) 569-613. 10.3390/macromol3030033Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM and Stroud MJ (2023). Lem2 is essential for cardiac development by maintaining nuclear integrity. Oxford University Press Cardiovascular Research vol. 119, (11) 2074-2088. 10.1093/cvr/cvad0612022
Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T and Krause S (2022). Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids. Elsevier Biosensors and Bioelectronics 10.1016/j.bios.2022.115024Marhuenda E, Iskratsch T and Xanthis I (2022). Crosstalk between cell-matrix and cell-cell signaling in cardiomyocyte mechanosensing. Elsevier Journal of Molecular and Cellular Cardiology vol. 173, 10.1016/j.yjmcc.2022.08.190Swiatlowska P, Sit B, Feng Z, Marhuenda E, Zhou X, Xiao Q, Shanahan C, Yu C-H and Iskratsch T (2022). Mechanoregulation of vascular smooth muscle cells phenotype in atherosclerosis. Elsevier Journal of Molecular and Cellular Cardiology vol. 173, 41-42. 10.1016/j.yjmcc.2022.08.083Marhuenda E, Pandey P, Xanthis I, O'Neill C and Iskratsch T (2022). The cardiomyocyte mechanical code – Mechanical imprinting of talin interactions regulate cardiomyocyte mechanosensing and function. Elsevier Journal of Molecular and Cellular Cardiology vol. 173, 10.1016/j.yjmcc.2022.08.197Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M, HUANG D, Junquiang H, Gondarenko S, Hone J, Gadegaard N and Palma M (2022). Regulation of Cardiomyocyte Adhesion and
Mechanosignalling Through Distinct Nanoscale Behaviour of
Integrin Ligands Mimicking Healthy or Fibrotic ECM. The Royal Society Philosophical Transactions of The Royal Society B: Biological Sciences 10.1098/rstb.2022.0021Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T (2022). Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching. American Association For The Advancement of Science Science Advances 10.1126/sciadv.abm34712021
Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot JP, Duffau H, Dennis JW, Cornu D and Bakalara N (2021). Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing. Journal of Experimental and Clinical Cancer Research vol. 40, (1) 10.1186/s13046-021-01925-7Sixto-López Y, Marhuenda E, García-Vazquez JB, Fragoso-Vazquez MJ, Rosales-Hernández MC, Zacarías-Lara O, Méndez-Luna D, Gómez-Vidal JA, Cornu D, Norbert B and Correa-Basurto J (2021). Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells. Springer Nature Cellular and Molecular Neurobiology vol. 42, (6) 1909-1920. 10.1007/s10571-021-01072-92020
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones GE, Yu C-H and Iskratsch T (2020). Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching. Cold Spring Harbor Laboratory 10.1101/2020.12.27.424498Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot J-P, Duffau H, Dennis JW, Cornu D and Bakalara N (2020). Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing. Cold Spring Harbor Laboratory 10.1101/2020.09.25.3137832019
Saleh A, Marhuenda E, Fabre C, Hassani Z, Weille JD, Boukhaddaoui H, Guelfi S, Maldonado IL, Hugnot J-P, Duffau H, Bauchet L, Cornu D and Bakalara N (2019). A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-β1 expression. Springer Nature Scientific Reports vol. 9, (1) 10.1038/s41598-019-51108-w