Dr Emilie Marhuenda

Emilie Marhuenda

PDRA

School of Engineering and Materials Science
Queen Mary University of London
ORCiD LinkedIn

Research

Cardiomyocyte, Mechanobiology, Heart Disease, Intercalated Discs, Cell-cell signaling, Mechanosensing

Underpinning Bioengineering, Cardiovascular Models

Publications

Publications of specific relevance to Predictive in vitro Models

2023

Ross JA, Arcos-Villacis N, Battey E, Boogerd C, Orellana CA, Marhuenda E, Swiatlowska P, Hodzic D, Prin F, Mohun T, Catibog N, Tapia O, Gerace L, Iskratsch T, Shah AM and Stroud MJ (2023). Lem2 is essential for cardiac development by maintaining nuclear integrity. Cardiovascular Research  vol. 119, (11) 2074-2088. 10.1093/cvr/cvad061
Fromager B, Marhuenda E, Louis B, Bakalara N, Cambedouzou J and Cornu D (2023). Recent Advances in Electrospun Fibers for Biological Applications. Mdpi  Macromol—a Journal of Macromolecular Research  vol. 3, (3) 569-613. 10.3390/macromol3030033

2022

Jacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T and Krause S (2022). Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoids. Elsevier  Biosensors and Bioelectronics  10.1016/j.bios.2022.115024
Marhuenda E, Iskratsch T and Xanthis I (2022). Crosstalk between cell-matrix and cell-cell signaling in cardiomyocyte mechanosensing. Elsevier  Journal of Molecular and Cellular Cardiology  vol. 173, 10.1016/j.yjmcc.2022.08.190
Swiatlowska P, Sit B, Feng Z, Marhuenda E, Zhou X, Xiao Q, Shanahan C, Yu C-H and Iskratsch T (2022). Mechanoregulation of vascular smooth muscle cells phenotype in atherosclerosis. Elsevier  Journal of Molecular and Cellular Cardiology  vol. 173, 41-42. 10.1016/j.yjmcc.2022.08.083
Marhuenda E, Pandey P, Xanthis I, O'Neill C and Iskratsch T (2022). The cardiomyocyte mechanical code – Mechanical imprinting of talin interactions regulate cardiomyocyte mechanosensing and function. Elsevier  Journal of Molecular and Cellular Cardiology  vol. 173, 10.1016/j.yjmcc.2022.08.197
Iskratsch T, Hawkes W, Marhuenda E, Reynolds P, O'Neill C, PANDEY P, Wilson D, FREELEY M, HUANG D, Junquiang H, Gondarenko S, Hone J, Gadegaard N and Palma M (2022). Regulation of Cardiomyocyte Adhesion and Mechanosignalling Through Distinct Nanoscale Behaviour of Integrin Ligands Mimicking Healthy or Fibrotic ECM. The Royal Society  Philosophical Transactions of The Royal Society B: Biological Sciences  10.1098/rstb.2022.0021
Sixto-López Y, Marhuenda E, García-Vazquez JB, Fragoso-Vazquez MJ, Rosales-Hernández MC, Zacarías-Lara O, Méndez-Luna D, Gómez-Vidal JA, Cornu D, Norbert B and Correa-Basurto J (2022). Targeting Several Biologically Reported Targets of Glioblastoma Multiforme by Assaying 2D and 3D Cultured Cells. Cellular and Molecular Neurobiology  vol. 42, (6) 1909-1920. 10.1007/s10571-021-01072-9
Swiatlowska P, Sit BHM, Zhen F, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T (2022). Pressure and stiffness sensing together regulate vascular smooth muscle cell phenotype switching. American Association For The Advancement of Science  Science Advances  10.1126/sciadv.abm3471

2021

Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot JP, Duffau H, Dennis JW, Cornu D and Bakalara N (2021). Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing. Journal of Experimental and Clinical Cancer Research  vol. 40, (1) 10.1186/s13046-021-01925-7

2020

Swiatlowska P, Sit B, Feng Z, Marhuenda E, Xanthis I, Zingaro S, Ward M, Zhou X, Xiao Q, Shanahan C, Jones G, Yu C-H and Iskratsch T (2020). Matrix stiffness and blood pressure together regulate vascular smooth muscle cell phenotype switching. 10.1101/2020.12.27.424498
Marhuenda E, Fabre C, Zhang C, Martin-Fernandez M, Iskratsch T, Saleh A, Bauchet L, Cambedouzou J, Hugnot J-P, Duffau H, Dennis J, Cornu D and Bakalara N (2020). Glioma stem cells invasive phenotype at optimal stiffness is driven by MGAT5 dependent mechanosensing. 10.1101/2020.09.25.313783

2019

Saleh A, Marhuenda E, Fabre C, Hassani Z, Weille JD, Boukhaddaoui H, Guelfi S, Maldonado IL, Hugnot J-P, Duffau H, Bauchet L, Cornu D and Bakalara N (2019). A novel 3D nanofibre scaffold conserves the plasticity of glioblastoma stem cell invasion by regulating galectin-3 and integrin-β1 expression. Sci Rep  vol. 9, (1) 10.1038/s41598-019-51108-w