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Prof. Daniel Pennington

Daniel Pennington

Professor of Molecular Biology and Centre Lead for Immunobiology

Centre for Immunobiology, Blizard Institute, School of Medicine
Queen Mary University of London
02078822302

www.qmul.ac.uk/blizard/all-staff/profiles/daniel-j-pennington.html
ORCiD

Research

Immunology, T cells

Interests

Expertise: my lab runs several thymic organ culture models, e.g. using the stromal OP9-DL1 cell line, hanging drop thymic organ culture, and standard organ cultures. We are interested in exploring the use of the Emulate Centre.

Publications

Publications of specific relevance to Predictive in vitro Models

2021

Pennington D, Lynch L, Silva-Santos B, Lopes N, McIntyre C, Martin S, Sumaria N and Raverdeau M (2021). Distinct metabolic programmes established in the thymus control effector functions of gd T cell subsets in tumour microenvironments. Nature Research  Nature Immunology  179-192. 10.1038/s41590-020-00848-3

2020

Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK, Dias J, James LK, Thomas G, Lee WYJ, Betley J, Cavlan O, Leech A, Deane CM, Seoane J, Caldas C, Pennington DJ, Pfeffer P and Osbourn J (2020). Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures. Frontiers in Immunology  vol. 11, 10.3389/fimmu.2020.605170
Clohosey ML, Mann BT, Ryan PL, Apanasovich TV, Maggirwar SB, Pennington DJ and Soriano-Sarabia N (2020). Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals. Cells  vol. 9, (12) 10.3390/cells9122568
Chao-Chu J, Murtough S, Zaman N, Pennington DJ, Blaydon DC and Kelsell DP (2020). iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility. Journal of Investigative Dermatology  10.1016/j.jid.2020.09.010

2019

Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC, Pennington DJ and Kelsell DP (2019). 454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus. Journal of Investigative Dermatology  vol. 139, (5) 10.1016/j.jid.2019.03.530
Sumaria N, Martin S and Pennington DJ (2019). Developmental origins of murine γδ T-cell subsets. Immunology  vol. 156, (4) 299-304. 10.1111/imm.13032
Edelblum K, Gustafsson K, Pennington DJ, Willcox BE and Ribot JC (2019). Bordeaux 2018: Wine, Cheese, and γδ T Cells. Front Immunol  vol. 10, 10.3389/fimmu.2019.02544

2017

Grandjean CL, Sumaria N, Martin S and Pennington DJ (2017). Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ(+)CD8αα(+) intraepithelial lymphocytes. Scientific Reports  vol. 7, (1) 10.1038/s41598-017-09368-x
CABRERA CP, MANSON J, SHEPHERD JM#34122#, TORRANCE HD, WATSON D#37299#, LONGHI MP#31497#, HOTI M, PATEL MB, O'DWYER M#29886#, NOURSHARGH S#20399#, PENNINGTON DJ#19417#, BARNES MR#29697# and BROHI K#22103# (2017). Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma. Public Library of Science (Plos)  Plos Medicine  10.1371/journal.pmed.1002352
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB, O Dwyer M, Nourshargh S, Pennington DJ, Barnes MR and Brohi K (2017). Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study. Plos Medicine  vol. 14, (7) 10.1371/journal.pmed.1002352
Sumaria N, Grandjean CL, Silva-Santos B and Pennington DJ (2017). Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells. Cell Press  Cell Rep  vol. 19, (12) 2469-2476. 10.1016/j.celrep.2017.05.071
Muñoz-Ruiz M, Sumaria N, Pennington DJ and Silva-Santos B (2017). Thymic Determinants of γδ T Cell Differentiation. Trends Immunol  vol. 38, (5) 336-344. 10.1016/j.it.2017.01.007
Fechter K, Dorronsoro A, Jakobsson E, Ferrin I, Lang V, Sepulveda P, Pennington DJ and Trigueros C (2017). IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells. Public Library of Science  Plos One  vol. 12, (1) e0169362-e0169362. 10.1371/journal.pone.0169362

2016

Ryan PL, Sumaria N, Holland CJ, Bradford CM, Izotova N, Grandjean CL, Jawad AS, Bergmeier LA and PENNINGTON DJ (2016). Heterogeneous yet stable Vδ2(+) T cell profiles define distinct cytotoxic effector potentials in healthy human individuals. National Academy of Sciences  Proceedings of The National Academy of Sciences  vol. 113, (50) 14378-14383. 10.1073/pnas.1611098113
Manson J, Cole E, De Ath HD, Vulliamy P, Meier U, Pennington D and Brohi K (2016). Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients. Critical Care  vol. 20, (1) 10.1186/s13054-016-1341-2
Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E and Silva-Santos B (2016). TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets. Nature Immunology  10.1038/ni.3424
Stoenchev KV and Pennington DJ (2016). Structure and Function of TCRγδ Receptors. Encyclopedia of Immunobiology  10.1016/b978-0-12-374279-7.05009-8

2015

Torrance H#32046#, Brohi K#22103#, Warnes G, Owen HC, Hinds CJ#21305#, Pennington DJ#19417# and O'Dwyer MJ#29886# (2015). T-helper cell polarisation following severe polytrauma. Intensive Care Med Exp  vol. 3, (Suppl 1) 10.1186/2197-425X-3-S1-A848
Rei M, Pennington DJ and Silva-Santos B (2015). The emerging Protumor role of γδ T lymphocytes: implications for cancer immunotherapy. Cancer Res  vol. 75, (5) 798-802. 10.1158/0008-5472.CAN-14-3228

2014

Turner MD, Nedjai B, Hurst T and Pennington DJ (2014). Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease. Biochim Biophys Acta  vol. 1843, (11) 2563-2582. 10.1016/j.bbamcr.2014.05.014
Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ and Silva-Santos B (2014). Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages. Proc Natl Acad Sci U S A  vol. 111, (34) E3562-E3570. 10.1073/pnas.1403424111
Dorronsoro A, Ferrin I, Salcedo JM, Jakobsson E, Fernández-Rueda J, Lang V, Sepulveda P, Fechter K, Pennington D and Trigueros C (2014). Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κB. Eur J Immunol  vol. 44, (2) 480-488. 10.1002/eji.201343668

2013

Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ and Silva-Santos B (2013). Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets. Nat Immunol  vol. 14, (10) 1093-1100. 10.1038/ni.2702
Prinz I, Silva-Santos B and Pennington DJ (2013). Functional development of γδ T cells. Eur J Immunol  vol. 43, (8) 1988-1994. 10.1002/eji.201343759
Coquet JM, Ribot JC, B ba a N, Middendorp S, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D, Jacobs H, Pennington DJ, Silva-Santos B and Borst J (2013). Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway. J Exp Med  vol. 210, (4) 715-728. 10.1084/jem.20112061

2012

Michel M-L, Pang DJ, Haque SFY, Potocnik AJ, Pennington DJ and Hayday AC (2012). Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells. Proc Natl Acad Sci U S A  vol. 109, (43) 17549-17554. 10.1073/pnas.1204327109
Pang DJ, Neves JF, Sumaria N and Pennington DJ (2012). Understanding the complexity of γδ T-cell subsets in mouse and human. Immunology  vol. 136, (3) 283-290. 10.1111/j.1365-2567.2012.03582.x

2011

Turchinovich G and Pennington DJ (2011). T cell receptor signalling in γδ cell development: strength isn't everything. Trends Immunol  vol. 32, (12) 567-573. 10.1016/j.it.2011.09.005
Mahtani-Patching J, Neves JF, Pang DJ, Stoenchev KV, Aguirre-Blanco AM, Silva-Santos B and Pennington DJ (2011). PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization. Sci Signal  vol. 4, (182) 10.1126/scisignal.2001765

2010

Cárcamo-Orive I, Gaztelumendi A, Delgado J, Tejados N, Dorronsoro A, Fernández-Rueda J, Pennington DJ and Trigueros C (2010). Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk. J Bone Miner Res  vol. 25, (10) 2115-2125. 10.1002/jbmr.120
Afifi A, Raja SG, Pennington DJ and Tsang VT (2010). For neonates undergoing cardiac surgery does thymectomy as opposed to thymic preservation have any adverse immunological consequences? Interact Cardiovasc Thorac Surg  vol. 11, (3) 287-291. 10.1510/icvts.2010.237172
Sengupta N, MacFie TS, MacDonald TT, Pennington D and Silver AR (2010). Cancer immunoediting and spontaneous tumor regression. Pathol Res Pract  vol. 206, (1) 1-8. 10.1016/j.prp.2009.10.001

2009

Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J, Hayday AC, Pennington DJ and Silva-Santos B (2009). CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets. Nat Immunol  vol. 10, (4) 427-436. 10.1038/ni.1717
McKnight A and Pennington DJ (2009). HIV Vaccine Approaches. Encyclopedia of Life Sciences  John Wiley & Sons, Ltd: Chichester.  10.1002/9780470015902.a0021550

2008

Sancho D, Mourão-Sá D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR and Reis e Sousa C (2008). Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin. J Clin Invest  vol. 118, (6) 2098-2110. 10.1172/JCI34584
Hunt KA#21075#, Zhernakova A, Turner G, Heap GAR#25406#, Franke L#21569#, Bruinenberg M, Romanos J, Dinesen LC, Ryan AW, Panesar D, Gwilliam R, Takeuchi F, McLaren WM, Holmes GKT, Howdle PD, Walters JRF, Sanders DS, Playford RJ#20333#, Trynka G, Mulder CJJ, Mearin ML, Verbeek WHM, Trimble V, Stevens FM, O'Morain C, Kennedy NP, Kelleher D, Pennington DJ#19417#, Strachan DP and McArdle WL (2008). Newly identified genetic risk variants for celiac disease related to the immune response. Nat Genet  vol. 40, (4) 395-402. 10.1038/ng.102

2007

Hayday AC and Pennington DJ (2007). Key factors in the organized chaos of early T cell development. Nat Immunol  vol. 8, (2) 137-144. 10.1038/ni1436

2006

Pennington DJ, Silva-Santos B, Silberzahn T, Escorcio-Correia M, Woodward MJ, Roberts SJ, Smith AL, Dyson PJ and Hayday AC (2006). Early events in the thymus affect the balance of effector and regulatory T cells. Nature  vol. 444, (7122) 1073-1077. 10.1038/nature06051

2005

Pennington DJ, Silva-Santos B, Correia M and Hayday AC (2005). The regulation of gamma delta cell functional potential by alpha alpha beta T cell progenitors in the thymus. Immunology  vol. 116, 88-88.
Pennington DJ, Silva-Santos B and Hayday AC (2005). Gammadelta T cell development--having the strength to get there. Curr Opin Immunol  vol. 17, (2) 108-115. 10.1016/j.coi.2005.01.009
Silva-Santos B, Pennington DJ and Hayday AC (2005). Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors. Science  vol. 307, (5711) 925-928. 10.1126/science.1103978
Pennington DJ, Vermijlen D, Wise EL, Clarke SL, Tigelaar RE and Hayday AC (2005). The integration of conventional and unconventional T cells that characterizes cell-mediated responses. Adv Immunol  vol. 87, 27-59. 10.1016/S0065-2776(05)87002-6

2003

Comalada M, Xaus J, Valledor AF, López-López C, Pennington DJ and Celada A (2003). PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages. Am J Physiol Cell Physiol  vol. 285, (5) C1235-C1245. 10.1152/ajpcell.00228.2003
Pennington DJ, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise EL, Tigelaar RE, Owen MJ and Hayday AC (2003). The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells. Nat Immunol  vol. 4, (10) 991-998. 10.1038/ni979
Hayday AC, Pennington DJ and Giuggio VM (2003). Genomics and immunology. Semin Immunol  vol. 15, (4) 201-208. 10.1016/s1044-5323(03)00045-9
Trigueros C, Hozumi K, Silva-Santos B, Bruno L, Hayday AC, Owen MJ and Pennington DJ (2003). Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage. Eur J Immunol  vol. 33, (7) 1968-1977. 10.1002/eji.200323831
Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Reis e Sousa C, Ozato K and Sher A (2003). Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells. Blood  vol. 101, (1) 305-310. 10.1182/blood-2002-04-1088

2002

Saurin AT, Pennington DJ, Raat NJH, Latchman DS, Owen MJ and Marber MS (2002). Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts. Cardiovasc Res  vol. 55, (3) 672-680. 10.1016/s0008-6363(02)00325-5
Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K, Dou X, Ponticos M, Black C, Bernabeu C, Jackman JK, Findell PR and Connolly MK (2002). Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts. Arthritis Rheum  vol. 46, (7) 1857-1865. 10.1002/art.10333
Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M and Reis e Sousa C (2002). CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells. J Immunol  vol. 168, (12) 6057-6065. 10.4049/jimmunol.168.12.6057
Holmes A, Shi-Wen X, Ponticos M, Rajkumar V, Pennington D, Mukerjee D, Abraham DJ and Black CM (2002). CONNECTIVE TISSUE GROWTH FACTOR PRODUCED BY LUNG FIBROBLASTS IN RESPONSE TO INJURY MEDIATES EXTRACELLULAR MATRIX DEPOSITION IN BLEOMYCIN-INDUCED LUNG FIBROSIS. Rheumatology  vol. 41, 58-58.

2001

Castrillo A, Pennington DJ, Otto F, Parker PJ, Owen MJ and Boscá L (2001). Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection. J Exp Med  vol. 194, (9) 1231-1242. 10.1084/jem.194.9.1231

2000

Saurin AT, Pennington DJ, Raat H, Owen MJ and Marber MS (2000). Ischemic preconditioning in isolated mouse hearts - An essential role for PKC-epsilon. Circulation  vol. 102, (18) 155-155.
Shi-wen X, Pennington D, Holmes A, Leask A, Bradham D, Beauchamp JR, Fonseca C, du Bois RM, Martin GR, Black CM and Abraham DJ (2000). Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis. Exp Cell Res  vol. 259, (1) 213-224. 10.1006/excr.2000.4972
Buckland J, Pennington DJ, Bruno L and Owen MJ (2000). Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development. Eur J Immunol  vol. 30, (1) 8-18. 10.1002/1521-4141(200001)30:1<8::AID-IMMU8>3.0.CO;2-8

1999

Holmes A, Fonseca C, Pennington D, Shiwen X, Rajkumar V, Black C and Abraham D (1999). Identification of over expressed genes involved in the maintance of fibrosis: representational difference analysis of scleroderma fibroblasts. Arthritis Rheum  vol. 42, (9) S203-S203.

1997

Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA and Abraham DJ (1997). HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism. Genes Funct  vol. 1, (5-6) 321-335. 10.1046/j.1365-4624.1997.00029.x

1995

Brady HJ, Abraham DJ, Pennington DJ, Miles CG, Jenkins S and Dzierzak EA (1995). Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice. J Virol  vol. 69, (12) 7622-7629. 10.1128/JVI.69.12.7622-7629.1995
ABRAHAM D, PENNINGTON D, MILES C, JENKINS S, BRADY H and DZIERZAK E (1995). T-CELLS FROM HIV-1 TAT TRANSGENIC MICE SHOW ALTERED CYTOKINE EXPRESSION. J Cell Biochem  200-200.

1994

Brady HJ, Pennington DJ and Dzierzak EA (1994). Transgenic mice as models of human immunodeficiency virus expression and related cellular effects. J Gen Virol  vol. 75 ( Pt 10), 2549-2558. 10.1099/0022-1317-75-10-2549
Brady HJ, Miles CG, Pennington DJ and Dzierzak EA (1994). Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses. Proc Natl Acad Sci U S A  vol. 91, (1) 365-369. 10.1073/pnas.91.1.365

1993

Brady HJ, Pennington DJ, Miles CG and Dzierzak EA (1993). CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration. Embo J  vol. 12, (13) 4923-4932. 10.1002/j.1460-2075.1993.tb06186.x
Brady HJ, Miles CG, Pennington DJ and Dzierzak EA (1993). Studies of HIV-2 promoter activity and cell specific ablation. Leukemia  vol. 7 Suppl 2, S61-S65.
DZIERZAK EA, MILES C, PENNINGTON D and BRADY HJM (1993). SPECIFIC ABLATION OF HIV-TAT EXPRESSING CELLS BY CONDITIONALLY TOXIC RETROVIRUSES. J Cell Biochem  249-249.

Grants

Grants of specific relevance to Predictive in vitro Models
Defining and predicting the innate immune response to critical injury
Brohi KH, Pennington DJ and Barnes MR
£874,563 Medical Research Council (01-01-2019 - 31-12-2021)
Summary
Understanding thymic acquisition of gamma/delta T cell effector function
Pennington DJ
£464,810 Biotechnology and Biological Sciences Research Council (31-07-2018 - 30-07-2021)
Summary


Understanding human gammadelta cell biology to advise immunotherapeutic strategies against leukemia and lymphoma
Pennington D
USD247,254 Bloodwise (12-01-2015 - 11-03-2018)
Summary
Understanding human gammadelta cell biology to advise immunotherapeutic strategies against leukaemia and lymphoma
Pennington DJ
£247,254 Leukaemia and Lymphoma Research (12-01-2015 - 11-01-2018)
Understanding T cell receptor (TCR) signalling requirements for thymic gamma/delta cell development; are gamma/delta cells selected through their TCR?.
Pennington DJ
£293,533 Wellcome Trust (01-09-2011 - 31-10-2015)
Summary
Foxp3(+) natural T-reg cell development in the thymus.
Pennington DJ
£175,688 Wellcome Trust (01-02-2009 - 31-01-2012)
Summary