Prof Daniel Pennington

Daniel Pennington

Professor of Molecular Biology and Centre Lead for Immunobiology

Centre for Immunobiology, Blizard Institute, School of Medicine
Queen Mary University of London
02078822302
www.qmul.ac.uk/blizard/all-staff/profiles/daniel-j-pennington.html
ORCID

Research

Immunology, T cells

Infectious Disease and Inflammation Models, Skin Models

Interests

Expertise: my lab runs several thymic organ culture models, e.g. using the stromal OP9-DL1 cell line, hanging drop thymic organ culture, and standard organ cultures. We are interested in exploring the use of the Emulate Centre.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

010 Keratin 76 expression in Thymic Epithelial Cells is Necessary for Skin T cell Tolerance
Gelmetti M, Tomas I, Ragazzini R, Cautela M, Campinoti S, Torre M, Bonfanti P
Journal of Investigative Dermatology, Elsevier vol. 144 (12) 
01-12-2024
IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors
Wiesheu R, Edwards SC, Hedley A, Hall H, Tosolini M, Fares da Silva MGF, Sumaria N, Castenmiller SM et al.
The Embo Journal, Springer Nature vol. 43 (14), 2878-2907.  
30-05-2024
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasms
Sumaria N, Fiala GJ, Inácio D, Curado-Avelar M, Cachucho A, Pinheiro R, Wiesheu R, Kimura S et al.
Nature Immunology, Springer Nature vol. 25 (7), 1207-1217.  
27-05-2024
Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin Sulfate
Hirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S et al.
Cancer Research Communications, American Association For Cancer Research (Aacr) vol. 4 (4), 970-985.  
03-04-2024

2023

Investigating iRHOM2-Associated Transcriptional Changes in Tylosis With Esophageal Cancer
Murtough S, Babu D, Webb CM, Picard HLD, McGinty LA, Chao-Chu J, Pink R, Silver AR et al.
Gastro Hep Advances, Elsevier vol. 3 (3), 385-395.  
26-12-2023
1035 Understanding dynamic immune responses within a 3D microfluidic model of human skin
Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J
Journal of Investigative Dermatology, Elsevier vol. 143 (5) 
01-05-2023
Deep Characterization of Human γδ T Cell Subsets Defines Lineage-Specific Traits
Mann BT, Sanz M, Ryan P, Bosque A, Pennington D, Hackstein H, Soriano-Sarabia N
The Journal of Immunology, Oxford University Press (Oup) vol. 210 (Supplement_1), 167.15-167.15.  
01-05-2023
Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancer
Hirani P, Alonge KM, Pennington DJ, Cutillas PR, Wight TN, Pearce OM
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 5841-5841.  
04-04-2023
Deep characterization of human γδ T cell subsets defines shared and lineage-specific traits
Sanz M, Mann BT, Ryan PL, Bosque A, Pennington DJ, Hackstein H, Soriano-Sarabia N
Frontiers in Immunology, Frontiers vol. 14 
31-03-2023
Understanding dynamic immune responses within a 3D microfluidic model of human skin
Hindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J
 
01-01-2023

2022

ESDR173 - A Model to Unravel Pathways Underpinning Palmoplantar Homeostasis and Disease
Murtough S, Ramos Del Caño L, Delaney P, Webb C, Colom B, Jones P, Kelsell D
, Morressier 
22-09-2022
Decosus: An R Framework for Universal Integration of Cell Proportion Estimation Methods
Anene CA, Taggart E, Harwood CA, Pennington DJ, Wang J
Frontiers in Genetics, Frontiers vol. 13 
01-04-2022

2021

Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cells
Pennington D, Sumaria N, Martin S
Science Signaling, American Association For The Advancement of Science 
20-07-2021
Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathy
Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G et al.
Cell and Tissue Research, Springer Nature vol. 386 (1), 79-98.  
08-07-2021
Distinct metabolic programmes established in the thymus control effector functions of gd T cell subsets in tumour microenvironments
Pennington D, Lynch L, Silva-Santos B, Lopes N, McIntyre C, Martin S, Sumaria N, Raverdeau M
Nature Immunology, Nature Research, 179-192.  
18-01-2021
PI3K inhibition reveals a novel gamma delta T cell-associated transcriptional program during thymic development
Sumaria N, Martin S, Pennington DJ
 
01-01-2021

2020

Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune Signatures
Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al.
Frontiers in Immunology, Frontiers vol. 11 
15-12-2020
Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected Individuals
Clohosey ML, Mann BT, Ryan PL, Apanasovich TV, Maggirwar SB, Pennington DJ, Soriano-Sarabia N
Cells, Mdpi vol. 9 (12) 
01-12-2020
iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility
Chao-Chu J, Murtough S, Zaman N, Pennington DJ, Blaydon DC, Kelsell DP
Journal of Investigative Dermatology, Elsevier vol. 141 (4), 722-726.  
17-10-2020
Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signatures
Galson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al.
, Cold Spring Harbor Laboratory 
20-05-2020

2019

Bordeaux 2018: Wine, Cheese, and γδ T Cells
Edelblum K, Gustafsson K, Pennington DJ, Willcox BE, Ribot JC
Frontiers in Immunology, Frontiers vol. 10 
25-10-2019
423 Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal Cancer
Murtough S, Webb CM, Chikh A, Picard HLD, Pink R, Wang J, Fitzgerald R, Risk J et al.
 
01-09-2019
454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus
Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al.
Journal of Investigative Dermatology, Elsevier vol. 139 (5) 
01-05-2019
Developmental origins of murine γδ T‐cell subsets
Sumaria N, Martin S, Pennington DJ
Immunology, Wiley vol. 156 (4), 299-304.  
21-01-2019
iRhom2-mediated immune dysregulation: Impact on the skin and oesophagus
Webb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al.
 
01-01-2019

2017

Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ(+)CD8αα(+) intraepithelial lymphocytes
Grandjean CL, Sumaria N, Martin S, Pennington DJ
Scientific Reports, Springer Nature vol. 7 (1) 
06-09-2017
Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma
CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al.
Plos Medicine, Public Library of Science (Plos) 
17-07-2017
Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al.
Plos Med vol. 14 (7) 
01-07-2017
Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells.
Sumaria N, Grandjean CL, Silva-Santos B, Pennington DJ
Cell Rep, Cell Press vol. 19 (12), 2469-2476.  
20-06-2017
Thymic Determinants of γδ T Cell Differentiation
Muñoz-Ruiz M, Sumaria N, Pennington DJ, Silva-Santos B
Trends in Immunology, Elsevier vol. 38 (5), 336-344.  
09-03-2017
IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells.
Fechter K, Dorronsoro A, Jakobsson E, Ferrin I, Lang V, Sepulveda P, Pennington DJ, Trigueros C
Plos One, Public Library of Science vol. 12 (1), e0169362-e0169362.  
11-01-2017

2016

Heterogeneous yet stable Vδ2(+) T cell profiles define distinct cytotoxic effector potentials in healthy human individuals
Ryan PL, Sumaria N, Holland CJ, Bradford CM, Izotova N, Grandjean CL, Jawad AS, Bergmeier LA et al.
Proceedings of The National Academy of Sciences, National Academy of Sciences vol. 113 (50), 14378-14383.  
28-11-2016
TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets.
Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E et al.
Nature Immunology 
04-04-2016
Structure and Function of TCRγδ Receptors
Stoenchev KV
In Encyclopedia of Immunobiology, Elsevier 76-84.  
01-01-2016

2015

Immune Profiling of Immune Thrombocytopenia (ITP) Patients: Evidence for CD8 T Cell Involvement in the Disease
Escorcio-Correia M, Provan A
 
03-12-2015
T-helper cell polarisation following severe polytrauma
Torrance H, Brohi K, Warnes G, Owen H, Hinds C, Pennington D, O'Dwyer M
Intensive Care Medicine Experimental, Springer Nature vol. 3 (Suppl 1) 
01-10-2015
The Emerging Protumor Role of γδ T Lymphocytes: Implications for Cancer Immunotherapy
Rei M, Pennington DJ, Silva-Santos B
Cancer Research, American Association For Cancer Research (Aacr) vol. 75 (5), 798-802.  
01-03-2015
DNA Methylation Variation in Type 1 Diabetes Mellitus
Leslie RD, Dang MA, Hawa MI, Cunningham S, Bradford CM, Lowe R, Paul DM, Lernmark A et al.
 
01-01-2015

2014

Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.
Turner MD, Nedjai B, Hurst T, Pennington DJ
Biochim Biophys Acta vol. 1843 (11), 2563-2582.  
01-11-2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.
Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ et al.
Proc Natl Acad Sci U S A vol. 111 (34), E3562-E3570.  
26-08-2014
Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κB.
Dorronsoro A, Ferrin I, Salcedo JM, Jakobsson E, Fernández-Rueda J, Lang V, Sepulveda P, Fechter K et al.
Eur J Immunol vol. 44 (2), 480-488.  
01-02-2014
A requirement for PI3K in gamma delta T-cell development
Sumaria N, Grandjean CLA, Pang DJ, Neves JF, Silva-Santos B
 
01-01-2014

2013

Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets.
Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B
Nat Immunol vol. 14 (10), 1093-1100.  
01-10-2013
Functional development of γδ T cells.
Prinz I, Silva-Santos B, Pennington DJ
Eur J Immunol vol. 43 (8), 1988-1994.  
01-08-2013
Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.
Coquet JM, Ribot JC, Bąbała N, Middendorp S, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D et al.
J Exp Med vol. 210 (4), 715-728.  
08-04-2013

2012

Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells.
Michel M-L, Pang DJ, Haque SFY, Potocnik AJ, Pennington DJ, Hayday AC
Proc Natl Acad Sci U S A vol. 109 (43), 17549-17554.  
23-10-2012
Understanding the complexity of γδ T-cell subsets in mouse and human.
Pang DJ, Neves JF, Sumaria N, Pennington DJ
Immunology vol. 136 (3), 283-290.  
01-07-2012
CD70-CD27 interactions promote CD4+Foxp3+ regulatory T cell development in the thymic medulla
Ribot JC, Coquet JM, Middendorp S, van der Horst G, Babala N, Neves JF, Pennington DJ
 
01-01-2012
TCR requirements for gamma delta T cell development
Sumaria N, Pang DJ, Neves JF, Stoenchev KV
 
01-01-2012
The role of pTalpha isoforms in alpha beta T cell development
Grandjean CLA, Mahtani-Patching J, Pang DJ
 
01-01-2012

2011

T cell receptor signalling in γδ cell development: strength isn't everything.
Turchinovich G, Pennington DJ
Trends Immunol vol. 32 (12), 567-573.  
01-12-2011
PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.
Mahtani-Patching J, Neves JF, Pang DJ, Stoenchev KV, Aguirre-Blanco AM, Silva-Santos B, Pennington DJ
Sci Signal vol. 4 (182) 
19-07-2011

2010

Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk.
Cárcamo-Orive I, Gaztelumendi A, Delgado J, Tejados N, Dorronsoro A, Fernández-Rueda J, Pennington DJ, Trigueros C
J Bone Miner Res vol. 25 (10), 2115-2125.  
01-10-2010
For neonates undergoing cardiac surgery does thymectomy as opposed to thymic preservation have any adverse immunological consequences?
Afifi A, Raja SG, Pennington DJ, Tsang VT
Interact Cardiovasc Thorac Surg vol. 11 (3), 287-291.  
01-09-2010
Cancer immunoediting and spontaneous tumor regression.
Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR
Pathol Res Pract vol. 206 (1), 1-8.  
15-01-2010

2009

CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.
Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J et al.
Nat Immunol vol. 10 (4), 427-436.  
01-04-2009
HIV Vaccine Approaches
McKnight A, Pennington DJ
In Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester. 
01-01-2009

2008

Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.
Sancho D, Mourão-Sá D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR, Reis e Sousa C
J Clin Invest vol. 118 (6), 2098-2110.  
01-06-2008
Newly identified genetic risk variants for celiac disease related to the immune response.
Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC et al.
Nat Genet vol. 40 (4), 395-402.  
01-04-2008

2007

Key factors in the organized chaos of early T cell development.
Hayday AC, Pennington DJ
Nat Immunol vol. 8 (2), 137-144.  
01-02-2007

2006

Early events in the thymus affect the balance of effector and regulatory T cells
Pennington DJ, Silva-Santos B, Silberzahn T, Escorcio-Correia M, Woodward MJ, Dyson PJ
Nature vol. 444 (7122), 1073-1077.  
21-12-2006

2005

The regulation of gamma delta cell functional potential by alpha alpha beta T cell progenitors in the thymus
Pennington DJ, Silva-Santos B, Hayday AC
Immunology vol. 116, 88-88.  
01-12-2005
Gammadelta T cell development--having the strength to get there.
Pennington DJ, Silva-Santos B, Hayday AC
Curr Opin Immunol vol. 17 (2), 108-115.  
01-04-2005
Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors.
Silva-Santos B, Pennington DJ, Hayday AC
Science vol. 307 (5711), 925-928.  
11-02-2005
The integration of conventional and unconventional T cells that characterizes cell-mediated responses.
Pennington DJ, Vermijlen D, Wise EL, Clarke SL, Tigelaar RE, Hayday AC
Adv Immunol vol. 87, 27-59.  
01-01-2005

2003

PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages.
Comalada M, Xaus J, Valledor AF, López-López C, Pennington DJ, Celada A
Am J Physiol Cell Physiol vol. 285 (5), C1235-C1245.  
01-11-2003
The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells.
Pennington DJ, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise EL, Tigelaar RE, Owen MJ et al.
Nat Immunol vol. 4 (10), 991-998.  
01-10-2003
Genomics and immunology.
Hayday AC, Pennington DJ
Semin Immunol vol. 15 (4), 201-208.  
01-08-2003
Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage.
Trigueros C, Hozumi K, Silva-Santos B, Bruno L, Hayday AC, Owen MJ, Pennington DJ
Eur J Immunol vol. 33 (7), 1968-1977.  
01-07-2003
Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells.
Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Reis e Sousa C, Ozato K, Sher A
Blood vol. 101 (1), 305-310.  
01-01-2003

2002

Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts.
Saurin AT, Pennington DJ, Raat NJH, Latchman DS, Owen MJ, Marber MS
Cardiovasc Res vol. 55 (3), 672-680.  
15-08-2002
Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.
Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K et al.
Arthritis Rheum vol. 46 (7), 1857-1865.  
01-07-2002
CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells.
Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M, Reis e Sousa C
J Immunol vol. 168 (12), 6057-6065.  
15-06-2002
CONNECTIVE TISSUE GROWTH FACTOR PRODUCED BY LUNG FIBROBLASTS IN RESPONSE TO INJURY MEDIATES EXTRACELLULAR MATRIX DEPOSITION IN BLEOMYCIN-INDUCED LUNG FIBROSIS
Holmes A, Shi-Wen X, Ponticos M, Rajkumar V, Mukerjee D, Abraham DJ
Rheumatology vol. 41, 58-58.  
01-04-2002

2001

Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection.
Castrillo A, Pennington DJ, Otto F, Parker PJ, Owen MJ, Boscá L
J Exp Med vol. 194 (9), 1231-1242.  
05-11-2001

2000

Ischemic preconditioning in isolated mouse hearts - An essential role for PKC-epsilon
Saurin AT, Pennington DJ, Owen MJ
Circulation vol. 102 (18), 155-155.  
31-10-2000
Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.
Shi-wen X, Pennington D, Holmes A, Leask A, Bradham D, Beauchamp JR, Fonseca C, du Bois RM et al.
Exp Cell Res vol. 259 (1), 213-224.  
25-08-2000
Correction: Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development (European Journal of Immunology) (2000) 30, 1 (8-18))
Buckland J, Pennington DJ, Bruno L
European Journal of Immunology vol. 30 (3) 
03-05-2000
Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development.
Buckland J, Pennington DJ, Bruno L, Owen MJ
Eur J Immunol vol. 30 (1), 8-18.  
01-01-2000

1999

Identification of over expressed genes involved in the maintance of fibrosis: representational difference analysis of scleroderma fibroblasts.
Holmes A, Fonseca C, Pennington D, Rajkumar V, Black C
Arthritis Rheum vol. 42 (9), S203-S203.  
01-09-1999

1997

HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism.
Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA, Abraham DJ
Genes Funct vol. 1 (5-6), 321-335.  
01-12-1997

1995

Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice.
Brady HJ, Abraham DJ, Pennington DJ, Miles CG, Jenkins S, Dzierzak EA
J Virol vol. 69 (12), 7622-7629.  
01-12-1995
T-CELLS FROM HIV-1 TAT TRANSGENIC MICE SHOW ALTERED CYTOKINE EXPRESSION
ABRAHAM D, PENNINGTON D, MILES C, JENKINS S
J Cell Biochem, 200-200.  
02-04-1995

1994

Transgenic mice as models of human immunodeficiency virus expression and related cellular effects.
Brady HJ, Pennington DJ
J Gen Virol vol. 75 ( Pt 10), 2549-2558.  
01-10-1994
Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses.
Brady HJ, Miles CG, Pennington DJ, Dzierzak EA
Proc Natl Acad Sci U S A vol. 91 (1), 365-369.  
04-01-1994

1993

CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.
Brady HJ, Pennington DJ, Miles CG, Dzierzak EA
Embo J vol. 12 (13), 4923-4932.  
15-12-1993
Studies of HIV-2 promoter activity and cell specific ablation.
Brady HJ, Miles CG, Pennington DJ, Dzierzak EA
Leukemia vol. 7 Suppl 2, S61-S65.  
01-08-1993
SPECIFIC ABLATION OF HIV-TAT EXPRESSING CELLS BY CONDITIONALLY TOXIC RETROVIRUSES
DZIERZAK EA, MILES C, BRADY HJM
J Cell Biochem, 249-249.  
29-03-1993

Single-cell mass cytometry maps the evolution of immune cell signatures predictive of acute graft-versus-host disease
Aries JA, Charrot S, Theocharidis S, Meena M, Lee W-YJ, Correia ME, Pennington DJ, Cavenagh J et al.
In Biorxiv 
Multi-level orchestration of γδ T cell development and central nervous system inflammation by retinoic acid

In Biorxiv 
Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patients
MEIER U
Critical Care, Biomed Central 
Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis

Atherosclerosis 
Early cardiac inflammation as a driver of murine model of Arrhythmogenic Cardiomyopathy
Ng KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Tsisanova E, Walker SLM, Westaby JD et al.
In Biorxiv 
IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursors

In Biorxiv 
Perinatal thymic-derived CD8alphabeta-expressing gammadelta T cells are innate interferon-gamma producers that expand in IL-7R/STAT5B-driven neoplasms

Nature Immunology, Nature Research 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconTowards Precision Trauma Care: The Biological Injury Severity System
Karim Brohi, Michael Barnes and Daniel Pennington
£209,527 Rosetrees Trust
01-09-2025 - 31-08-2027
bullet iconQueen Mary & Barts Health Tuberculosis Centre
Adrian Martineau, Daniel Pennington and Christopher Griffiths
£3,718,611 Barts and the London Charity
01-01-2025 - 31-12-2027
bullet iconUnderstanding ethnicity-associated immunopathogenesis in sarcoidosis
Daniel Pennington
£316,680 Barts and the London Charity
15-01-2024 - 14-01-2027
bullet iconUnderstanding CD8beta(+) gamma/delta T cells: a novel subset of IFN-secreting innate-like T cells
Daniel Pennington
£615,373 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2023 - 31-01-2026

bullet iconInvestigation of the immune environment of keratinocyte skin cancer progression with implications for risk prediction and targeted prevention
Catherine Harwood, Jun Wang, Daniel Pennington and Irene Leigh
£531,092 Barts and the London Charity
26-09-2022 - 01-04-2024
bullet iconTuring Studentship- Sara Masarone
Daniel Pennington
£43,447 Alan Turing Institute, The
01-10-2019 - 31-03-2023
bullet iconDefining and predicting the innate immune response to critical injury
Karim Brohi, Michael Barnes and Daniel Pennington
£874,564 Medical Research Council
01-01-2019 - 31-12-2022
bullet iconUnderstanding thymic acquisition of gamma/delta T cell effector function
Daniel Pennington
£464,812 Biotechnology and Biological Sciences Research Council
01-08-2018 - 30-09-2022