Prof Daniel Pennington
Professor of Molecular Biology and Centre Lead for Immunobiology
Centre for Immunobiology, Blizard Institute, School of Medicine
Queen Mary University of London
Queen Mary University of London
Research
Immunology, T cells
Interests
Expertise: my lab runs several thymic organ culture models, e.g. using the stromal OP9-DL1 cell line, hanging drop thymic organ culture, and standard organ cultures. We are interested in exploring the use of the Emulate Centre.Publications
2024
010 Keratin 76 expression in Thymic Epithelial Cells is Necessary for Skin T cell ToleranceGelmetti M, Tomas I, Ragazzini R, Cautela M, Campinoti S, Torre M, Watt FM, Bonfanti P et al.
Journal of Investigative Dermatology, Elsevier vol. 144 (12)
01-12-2024
IL-27 maintains cytotoxic Ly6C+ γδ T cells that arise from immature precursorsWiesheu R, Edwards SC, Hedley A, Hall H, Tosolini M, Fares da Silva MGF, Sumaria N, Castenmiller SM et al.
The Embo Journal, Springer Nature vol. 43 (14), 2878-2907.
30-05-2024
Perinatal thymic-derived CD8αβ-expressing γδ T cells are innate IFN-γ producers that expand in IL-7R–STAT5B-driven neoplasmsSumaria N, Fiala GJ, Inácio D, Curado-Avelar M, Cachucho A, Pinheiro R, Wiesheu R, Kimura S et al.
Nature Immunology, Springer Nature vol. 25 (7), 1207-1217.
27-05-2024
Versican Associates with Tumor Immune Phenotype and Limits T-cell Trafficking via Chondroitin SulfateHirani P, McDermott J, Rajeeve V, Cutillas PR, Jones JL, Pennington DJ, Wight TN, Santamaria S et al.
Cancer Research Communications, American Association For Cancer Research (Aacr) vol. 4 (4), 970-985.
03-04-2024
2023
Investigating iRHOM2-Associated Transcriptional Changes in Tylosis With Esophageal CancerMurtough S, Babu D, Webb CM, Picard HLD, McGinty LA, Chao-Chu J, Pink R, Silver AR et al.
Gastro Hep Advances, Elsevier vol. 3 (3), 385-395.
26-12-2023
1035 Understanding dynamic immune responses within a 3D microfluidic model of human skinHindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J
Journal of Investigative Dermatology, Elsevier vol. 143 (5)
01-05-2023
Deep Characterization of Human γδ T Cell Subsets Defines Lineage-Specific TraitsMann BT, Sanz M, Ryan P, Bosque A, Pennington D, Hackstein H, Soriano-Sarabia N
The Journal of Immunology, Oxford University Press (Oup) vol. 210 (Supplement_1), 167.15-167.15.
01-05-2023
Abstract 5841: Exploring the role of versican in immune exclusion within triple negative breast cancerHirani P, Alonge KM, Pennington DJ, Cutillas PR, Wight TN, Pearce OM
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 5841-5841.
04-04-2023
Deep characterization of human γδ T cell subsets defines shared and lineage-specific traitsSanz M, Mann BT, Ryan PL, Bosque A, Pennington DJ, Hackstein H, Soriano-Sarabia N
Frontiers in Immunology, Frontiers vol. 14
31-03-2023
Understanding dynamic immune responses within a 3D microfluidic model of human skinHindle S, Taggart E, Blowes L, Pennington D, Singh B, Caley M, Connelly J
01-01-2023
2022
ESDR173 - A Model to Unravel Pathways Underpinning Palmoplantar Homeostasis and DiseaseMurtough S, Ramos Del Caño L, Delaney P, Webb C, Colom B, Jones P, Blaydon D, Kelsell D et al.
, Morressier
22-09-2022
Decosus: An R Framework for Universal Integration of Cell Proportion Estimation MethodsFrontiers in Genetics, Frontiers vol. 13
01-04-2022
2021
Constrained TCRγδ-associated Syk activity engages PI3K to facilitate thymic development of IL-17A–secreting γδ T cellsPennington D, Sumaria N, Martin S
Science Signaling, American Association For The Advancement of Science
20-07-2021
Early inflammation precedes cardiac fibrosis and heart failure in desmoglein 2 murine model of arrhythmogenic cardiomyopathyNg KE, Delaney PJ, Thenet D, Murtough S, Webb CM, Zaman N, Tsisanova E, Mastroianni G et al.
Cell and Tissue Research, Springer Science and Business Media Llc vol. 386 (1), 79-98.
08-07-2021
Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosisPark JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SC, Liou KCK, Lynn SE, Ng SS et al.
Atherosclerosis, Elsevier vol. 324, 58-68.
25-03-2021
Distinct metabolic programmes established in the thymus control effector functions of gd T cell subsets in tumour microenvironmentsPennington D, Lynch L, Silva-Santos B, Lopes N, McIntyre C, Martin S, Sumaria N, Raverdeau M
Nature Immunology, Nature Research, 179-192.
18-01-2021
PI3K inhibition reveals a novel gamma delta T cell-associated transcriptional program during thymic developmentSumaria N, Martin S, Pennington DJ
01-01-2021
2020
Deep Sequencing of B Cell Receptor Repertoires From COVID-19 Patients Reveals Strong Convergent Immune SignaturesGalson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al.
Frontiers in Immunology, Frontiers vol. 11
15-12-2020
Comparable Vδ2 Cell Functional Characteristics in Virally Suppressed People Living with HIV and Uninfected IndividualsClohosey ML, Mann BT, Ryan PL, Apanasovich TV, Maggirwar SB, Pennington DJ, Soriano-Sarabia N
Cells, Mdpi vol. 9 (12)
01-12-2020
iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral SusceptibilityChao-Chu J, Murtough S, Zaman N, Pennington DJ, Blaydon DC, Kelsell DP
Journal of Investigative Dermatology, Elsevier vol. 141 (4), 722-726.
17-10-2020
Deep sequencing of B cell receptor repertoires from COVID-19 patients reveals strong convergent immune signaturesGalson JD, Schaetzle S, Bashford-Rogers RJM, Raybould MIJ, Kovaltsuk A, Kilpatrick GJ, Minter R, Finch DK et al.
, Cold Spring Harbor Laboratory
20-05-2020
2019
Bordeaux 2018: Wine, Cheese, and γδ T CellsEdelblum K, Gustafsson K, Pennington DJ, Willcox BE, Ribot JC
Frontiers in Immunology, Frontiers vol. 10
25-10-2019
423 Type 2 Immunity Linked to iRhom2 and Tylosis with Oesophageal CancerMurtough S, Webb CM, Chikh A, Picard HLD, Pink R, Wang J, Fitzgerald R, Risk J et al.
01-09-2019
454 iRhom2-mediated immune dysregulation: Impact on the skin and oesophagusWebb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al.
Journal of Investigative Dermatology, Elsevier vol. 139 (5)
01-05-2019
Developmental origins of murine γδ T‐cell subsetsSumaria N, Martin S, Pennington DJ
Immunology, Wiley vol. 156 (4), 299-304.
21-01-2019
iRhom2-mediated immune dysregulation: Impact on the skin and oesophagusWebb C, Murtough S, Chikh A, Picard HLD, Wang J, Pink R, Risk JM, Fitzgerald RC et al.
01-01-2019
2017
Increased TCR signal strength in DN thymocytes promotes development of gut TCRαβ(+)CD8αα(+) intraepithelial lymphocytesGrandjean CL, Sumaria N, Martin S, Pennington DJ
Scientific Reports, Springer Nature vol. 7 (1)
06-09-2017
Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of TraumaCABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al.
Plos Medicine, Public Library of Science (Plos)
17-07-2017
Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al.
Plos Med vol. 14 (7)
01-07-2017
Strong TCRγδ Signaling Prohibits Thymic Development of IL-17A-Secreting γδ T Cells.Sumaria N, Grandjean CL, Silva-Santos B, Pennington DJ
Cell Rep, Cell Press vol. 19 (12), 2469-2476.
20-06-2017
Thymic Determinants of γδ T Cell DifferentiationMuñoz-Ruiz M, Sumaria N, Pennington DJ, Silva-Santos B
Trends in Immunology, Elsevier vol. 38 (5), 336-344.
09-03-2017
IFNγ Regulates Activated Vδ2+ T Cells through a Feedback Mechanism Mediated by Mesenchymal Stem Cells.Fechter K, Dorronsoro A, Jakobsson E, Ferrin I, Lang V, Sepulveda P, Pennington DJ, Trigueros C
Plos One, Public Library of Science vol. 12 (1), e0169362-e0169362.
11-01-2017
2016
Heterogeneous yet stable Vδ2(+) T cell profiles define distinct cytotoxic effector potentials in healthy human individualsRyan PL, Sumaria N, Holland CJ, Bradford CM, Izotova N, Grandjean CL, Jawad AS, Bergmeier LA et al.
Proceedings of The National Academy of Sciences, National Academy of Sciences vol. 113 (50), 14378-14383.
28-11-2016
TCR signal strength controls thymic differentiation of discrete proinflammatory γδ T cell subsets.Muñoz-Ruiz M, Ribot JC, Grosso AR, Gonçalves-Sousa N, Pamplona A, Pennington DJ, Regueiro JR, Fernández-Malavé E et al.
Nature Immunology
04-04-2016
Structure and Function of TCRγδ ReceptorsStoenchev KV, Pennington DJ
In Encyclopedia of Immunobiology, Elsevier 76-84.
01-01-2016
2015
Immune Profiling of Immune Thrombocytopenia (ITP) Patients: Evidence for CD8 T Cell Involvement in the DiseaseEscorcio-Correia M, Provan A, Pennington DJ
03-12-2015
T-helper cell polarisation following severe polytraumaTorrance H, Brohi K, Warnes G, Owen H, Hinds C, Pennington D, O'Dwyer M
Intensive Care Medicine Experimental, Springer Nature vol. 3 (Suppl 1)
01-10-2015
The Emerging Protumor Role of γδ T Lymphocytes: Implications for Cancer ImmunotherapyRei M, Pennington DJ, Silva-Santos B
Cancer Research, American Association For Cancer Research (Aacr) vol. 75 (5), 798-802.
01-03-2015
DNA Methylation Variation in Type 1 Diabetes MellitusLeslie RD, Dang MA, Hawa MI, Cunningham S, Bradford CM, Lowe R, Paul DM, Libertini E et al.
01-01-2015
2014
Cytokines and chemokines: At the crossroads of cell signalling and inflammatory disease.Turner MD, Nedjai B, Hurst T, Pennington DJ
Biochim Biophys Acta vol. 1843 (11), 2563-2582.
01-11-2014
Murine CD27(-) Vγ6(+) γδ T cells producing IL-17A promote ovarian cancer growth via mobilization of protumor small peritoneal macrophages.Rei M, Gonçalves-Sousa N, Lança T, Thompson RG, Mensurado S, Balkwill FR, Kulbe H, Pennington DJ et al.
Proc Natl Acad Sci U S A vol. 111 (34), E3562-E3570.
26-08-2014
Human mesenchymal stromal cells modulate T-cell responses through TNF-α-mediated activation of NF-κB.Dorronsoro A, Ferrin I, Salcedo JM, Jakobsson E, Fernández-Rueda J, Lang V, Sepulveda P, Fechter K et al.
Eur J Immunol vol. 44 (2), 480-488.
01-02-2014
A requirement for PI3K in gamma delta T-cell developmentSumaria N, Grandjean CLA, Pang DJ, Neves JF, Stoenchev KV, Silva-Santos B, Pennington DJ
01-01-2014
2013
Epigenetic and transcriptional signatures of stable versus plastic differentiation of proinflammatory γδ T cell subsets.Schmolka N, Serre K, Grosso AR, Rei M, Pennington DJ, Gomes AQ, Silva-Santos B
Nat Immunol vol. 14 (10), 1093-1100.
01-10-2013
Functional development of γδ T cells.Prinz I, Silva-Santos B, Pennington DJ
Eur J Immunol vol. 43 (8), 1988-1994.
01-08-2013
Epithelial and dendritic cells in the thymic medulla promote CD4+Foxp3+ regulatory T cell development via the CD27-CD70 pathway.Coquet JM, Ribot JC, Bąbała N, Middendorp S, van der Horst G, Xiao Y, Neves JF, Fonseca-Pereira D et al.
J Exp Med vol. 210 (4), 715-728.
08-04-2013
2012
Interleukin 7 (IL-7) selectively promotes mouse and human IL-17-producing γδ cells.Michel M-L, Pang DJ, Haque SFY, Potocnik AJ, Pennington DJ, Hayday AC
Proc Natl Acad Sci U S A vol. 109 (43), 17549-17554.
23-10-2012
Understanding the complexity of γδ T-cell subsets in mouse and human.Pang DJ, Neves JF, Sumaria N, Pennington DJ
Immunology vol. 136 (3), 283-290.
01-07-2012
CD70-CD27 interactions promote CD4+Foxp3+ regulatory T cell development in the thymic medullaRibot JC, Coquet JM, Middendorp S, van der Horst G, Babala N, Neves JF, Pennington DJ, Jacobs HB et al.
01-01-2012
TCR requirements for gamma delta T cell developmentSumaria N, Pang DJ, Neves JF, Stoenchev KV, Silva-Santos B, Pennington DJ
01-01-2012
The role of pTalpha isoforms in alpha beta T cell developmentGrandjean CLA, Mahtani-Patching J, Pang DJ, Pennington DJ
01-01-2012
2011
T cell receptor signalling in γδ cell development: strength isn't everything.Turchinovich G, Pennington DJ
Trends Immunol vol. 32 (12), 567-573.
01-12-2011
PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization.Mahtani-Patching J, Neves JF, Pang DJ, Stoenchev KV, Aguirre-Blanco AM, Silva-Santos B, Pennington DJ
Sci Signal vol. 4 (182)
19-07-2011
2010
Regulation of human bone marrow stromal cell proliferation and differentiation capacity by glucocorticoid receptor and AP-1 crosstalk.Cárcamo-Orive I, Gaztelumendi A, Delgado J, Tejados N, Dorronsoro A, Fernández-Rueda J, Pennington DJ, Trigueros C
J Bone Miner Res vol. 25 (10), 2115-2125.
01-10-2010
For neonates undergoing cardiac surgery does thymectomy as opposed to thymic preservation have any adverse immunological consequences?Afifi A, Raja SG, Pennington DJ, Tsang VT
Interact Cardiovasc Thorac Surg vol. 11 (3), 287-291.
01-09-2010
Cancer immunoediting and spontaneous tumor regression.Sengupta N, MacFie TS, MacDonald TT, Pennington D, Silver AR
Pathol Res Pract vol. 206 (1), 1-8.
15-01-2010
2009
CD27 is a thymic determinant of the balance between interferon-gamma- and interleukin 17-producing gammadelta T cell subsets.Ribot JC, deBarros A, Pang DJ, Neves JF, Peperzak V, Roberts SJ, Girardi M, Borst J et al.
Nat Immunol vol. 10 (4), 427-436.
01-04-2009
HIV Vaccine ApproachesMcKnight A, Pennington DJ
In Encyclopedia of Life Sciences, John Wiley & Sons, Ltd: Chichester.
01-01-2009
2008
Tumor therapy in mice via antigen targeting to a novel, DC-restricted C-type lectin.Sancho D, Mourão-Sá D, Joffre OP, Schulz O, Rogers NC, Pennington DJ, Carlyle JR, Reis e Sousa C
J Clin Invest vol. 118 (6), 2098-2110.
01-06-2008
Newly identified genetic risk variants for celiac disease related to the immune response.Hunt KA, Zhernakova A, Turner G, Heap GAR, Franke L, Bruinenberg M, Romanos J, Dinesen LC et al.
Nat Genet vol. 40 (4), 395-402.
01-04-2008
2007
Key factors in the organized chaos of early T cell development.Hayday AC, Pennington DJ
Nat Immunol vol. 8 (2), 137-144.
01-02-2007
2006
Early events in the thymus affect the balance of effector and regulatory T cellsPennington DJ, Silva-Santos B, Silberzahn T, Escorcio-Correia M, Woodward MJ, Roberts SJ, Smith AL, Dyson PJ et al.
Nature vol. 444 (7122), 1073-1077.
21-12-2006
2005
The regulation of gamma delta cell functional potential by alpha alpha beta T cell progenitors in the thymusPennington DJ, Silva-Santos B, Correia M, Hayday AC
Immunology vol. 116, 88-88.
01-12-2005
Gammadelta T cell development--having the strength to get there.Pennington DJ, Silva-Santos B, Hayday AC
Curr Opin Immunol vol. 17 (2), 108-115.
01-04-2005
Lymphotoxin-mediated regulation of gammadelta cell differentiation by alphabeta T cell progenitors.Silva-Santos B, Pennington DJ, Hayday AC
Science vol. 307 (5711), 925-928.
11-02-2005
The integration of conventional and unconventional T cells that characterizes cell-mediated responses.Pennington DJ, Vermijlen D, Wise EL, Clarke SL, Tigelaar RE, Hayday AC
Adv Immunol vol. 87, 27-59.
01-01-2005
2003
PKC epsilon is involved in JNK activation that mediates LPS-induced TNF-alpha, which induces apoptosis in macrophages.Comalada M, Xaus J, Valledor AF, López-López C, Pennington DJ, Celada A
Am J Physiol Cell Physiol vol. 285 (5), C1235-C1245.
01-11-2003
The inter-relatedness and interdependence of mouse T cell receptor gammadelta+ and alphabeta+ cells.Pennington DJ, Silva-Santos B, Shires J, Theodoridis E, Pollitt C, Wise EL, Tigelaar RE, Owen MJ et al.
Nat Immunol vol. 4 (10), 991-998.
01-10-2003
Genomics and immunology.Hayday AC, Pennington DJ, Giuggio VM
Semin Immunol vol. 15 (4), 201-208.
01-08-2003
Pre-TCR signaling regulates IL-7 receptor alpha expression promoting thymocyte survival at the transition from the double-negative to double-positive stage.Trigueros C, Hozumi K, Silva-Santos B, Bruno L, Hayday AC, Owen MJ, Pennington DJ
Eur J Immunol vol. 33 (7), 1968-1977.
01-07-2003
Essential role for ICSBP in the in vivo development of murine CD8alpha + dendritic cells.Aliberti J, Schulz O, Pennington DJ, Tsujimura H, Reis e Sousa C, Ozato K, Sher A
Blood vol. 101 (1), 305-310.
01-01-2003
2002
Targeted disruption of the protein kinase C epsilon gene abolishes the infarct size reduction that follows ischaemic preconditioning of isolated buffer-perfused mouse hearts.Saurin AT, Pennington DJ, Raat NJH, Latchman DS, Owen MJ, Marber MS
Cardiovasc Res vol. 55 (3), 672-680.
15-08-2002
Dysregulation of transforming growth factor beta signaling in scleroderma: overexpression of endoglin in cutaneous scleroderma fibroblasts.Leask A, Abraham DJ, Finlay DR, Holmes A, Pennington D, Shi-Wen X, Chen Y, Venstrom K et al.
Arthritis Rheum vol. 46 (7), 1857-1865.
01-07-2002
CD36 or alphavbeta3 and alphavbeta5 integrins are not essential for MHC class I cross-presentation of cell-associated antigen by CD8 alpha+ murine dendritic cells.Schulz O, Pennington DJ, Hodivala-Dilke K, Febbraio M, Reis e Sousa C
J Immunol vol. 168 (12), 6057-6065.
15-06-2002
CONNECTIVE TISSUE GROWTH FACTOR PRODUCED BY LUNG FIBROBLASTS IN RESPONSE TO INJURY MEDIATES EXTRACELLULAR MATRIX DEPOSITION IN BLEOMYCIN-INDUCED LUNG FIBROSISHolmes A, Shi-Wen X, Ponticos M, Rajkumar V, Pennington D, Mukerjee D, Abraham DJ, Black CM
Rheumatology vol. 41, 58-58.
01-04-2002
2001
Protein kinase Cepsilon is required for macrophage activation and defense against bacterial infection.Castrillo A, Pennington DJ, Otto F, Parker PJ, Owen MJ, Boscá L
J Exp Med vol. 194 (9), 1231-1242.
05-11-2001
2000
Ischemic preconditioning in isolated mouse hearts - An essential role for PKC-epsilonSaurin AT, Pennington DJ, Raat H, Owen MJ, Marber MS
Circulation vol. 102 (18), 155-155.
31-10-2000
Autocrine overexpression of CTGF maintains fibrosis: RDA analysis of fibrosis genes in systemic sclerosis.Shi-wen X, Pennington D, Holmes A, Leask A, Bradham D, Beauchamp JR, Fonseca C, du Bois RM et al.
Exp Cell Res vol. 259 (1), 213-224.
25-08-2000
Correction: Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development (European Journal of Immunology) (2000) 30, 1 (8-18))Buckland J, Pennington DJ, Bruno L, Owen MJ
European Journal of Immunology vol. 30 (3)
03-05-2000
Co-ordination of the expression of the protein tyrosine kinase p56(lck) with the pre-T cell receptor during thymocyte development.Buckland J, Pennington DJ, Bruno L, Owen MJ
Eur J Immunol vol. 30 (1), 8-18.
01-01-2000
1999
Identification of over expressed genes involved in the maintance of fibrosis: representational difference analysis of scleroderma fibroblasts.Holmes A, Fonseca C, Pennington D, Shiwen X, Rajkumar V, Black C, Abraham D
Arthritis Rheum vol. 42 (9), S203-S203.
01-09-1999
1997
HIV- I Nef severely impairs thymocyte development and peripheral T-cell function by a CD4-independent mechanism.Pennington DJ, Jenkins SA, Brady HJ, Miles CG, Dzierzak EA, Abraham DJ
Genes Funct vol. 1 (5-6), 321-335.
01-12-1997
1995
Altered cytokine expression in T lymphocytes from human immunodeficiency virus Tat transgenic mice.Brady HJ, Abraham DJ, Pennington DJ, Miles CG, Jenkins S, Dzierzak EA
J Virol vol. 69 (12), 7622-7629.
01-12-1995
T-CELLS FROM HIV-1 TAT TRANSGENIC MICE SHOW ALTERED CYTOKINE EXPRESSIONABRAHAM D, PENNINGTON D, MILES C, JENKINS S, BRADY H, DZIERZAK E
J Cell Biochem, 200-200.
02-04-1995
1994
Transgenic mice as models of human immunodeficiency virus expression and related cellular effects.Brady HJ, Pennington DJ, Dzierzak EA
J Gen Virol vol. 75 ( Pt 10), 2549-2558.
01-10-1994
Specific ablation of human immunodeficiency virus Tat-expressing cells by conditionally toxic retroviruses.Brady HJ, Miles CG, Pennington DJ, Dzierzak EA
Proc Natl Acad Sci U S A vol. 91 (1), 365-369.
04-01-1994
1993
CD4 cell surface downregulation in HIV-1 Nef transgenic mice is a consequence of intracellular sequestration.Brady HJ, Pennington DJ, Miles CG, Dzierzak EA
Embo J vol. 12 (13), 4923-4932.
15-12-1993
Studies of HIV-2 promoter activity and cell specific ablation.Brady HJ, Miles CG, Pennington DJ, Dzierzak EA
Leukemia vol. 7 Suppl 2, S61-S65.
01-08-1993
SPECIFIC ABLATION OF HIV-TAT EXPRESSING CELLS BY CONDITIONALLY TOXIC RETROVIRUSESDZIERZAK EA, MILES C, PENNINGTON D, BRADY HJM
J Cell Biochem, 249-249.
29-03-1993
Early changes within the lymphocyte population are associated with the development of multiple organ dysfunction syndrome in trauma patientsMEIER U
Critical Care, Biomed Central
Grants
Towards Precision Trauma Care: The Biological Injury Severity SystemKarim Brohi, Michael Barnes and Daniel Pennington
£209,527 Rosetrees Trust
01-09-2025 - 31-08-2027
Queen Mary & Barts Health Tuberculosis CentreAdrian Martineau, Daniel Pennington and Christopher Griffiths
£3,718,611 Barts and the London Charity
01-01-2025 - 31-12-2027
Understanding ethnicity-associated immunopathogenesis in sarcoidosisDaniel Pennington
£316,680 Barts and the London Charity
15-01-2024 - 14-01-2027
Understanding CD8beta(+) gamma/delta T cells: a novel subset of IFN-secreting innate-like T cellsDaniel Pennington
£615,373 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2023 - 31-01-2026
Investigation of the immune environment of keratinocyte skin cancer progression with implications for risk prediction and targeted preventionCatherine Harwood, Jun Wang, Daniel Pennington and Irene Leigh
£531,092 Barts and the London Charity
26-09-2022 - 01-04-2024
Turing Studentship- Sara MasaroneDaniel Pennington
£43,447 Alan Turing Institute, The
01-10-2019 - 31-03-2023
Defining and predicting the innate immune response to critical injuryKarim Brohi, Michael Barnes and Daniel Pennington
£874,564 Medical Research Council
01-01-2019 - 31-12-2022
Understanding thymic acquisition of gamma/delta T cell effector functionDaniel Pennington
£464,812 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2018 - 30-09-2022