Publications

Publications of specific relevance to Predictive in vitro Models
2023

Yip PK, Bremang M, Pike I, Ponnusamy V,
Michael-Titus AT and Shah DK (2023).
Newborns with Favourable Outcomes after Perinatal Asphyxia Have Upregulated Glucose Metabolism-Related Proteins in Plasma. Biomolecules vol. 13, (10)
10.3390/biom13101471
Dyall SC, Nessel I, Sharpe JA, Yip PK,
Michael-Titus AT and Shah DK (2023).
Long-chain omega-3 polyunsaturated fatty acids are reduced in neonates with substantial brain injury undergoing therapeutic hypothermia after hypoxic–ischemic encephalopathy. Frontiers in Neurology vol. 14,
10.3389/fneur.2023.12317432022

Thau-Zuchman O,
Pallier PN, Savelkoul PJM, Kuipers AAM, Verkuyl JM and
Michael-Titus AT (2022).
High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices. Frontiers in Neuroscience vol. 16,
10.3389/fnins.2022.926023
Gala AAD, Kumar H, Sedani S, Openshaw-Lawrence N, Verkuijl JM, Glogowski N, Steingold A, Ponnusamy V, Ekitzidou G, Yip P, Nessel I,
Michael-Titus AT, Roeselers G and Shah DK (2022).
Alterations in the Stool Microbiome in Newborns Undergoing Mild Therapeutic Hypothermia after Hypoxic-Ischemic Encephalopathy. Developmental Neuroscience vol. 44, (4-5) 373-383.
10.1159/000522523
Pradelli L, Adolph M, Calder PC, Deutz NE, Carmona TG,
Michael-Titus AT, Muscaritoli M and Singer P (2022).
Commentary on “Guidelines for the provision of nutrition support therapy in the adult critically ill patient: The American Society for Parenteral and Enteral Nutrition”. Journal of Parenteral and Enteral Nutrition vol. 46, (6) 1226-1227.
10.1002/jpen.2417
Teoh L, Ihalage AA, Harp S, Al-Khateeb ZF,
Michael-Titus AT, Tremoleda JL and Hao Y (2022).
Deep learning for behaviour classification in a preclinical brain injury model. Plos One vol. 17, (6 June)
10.1371/journal.pone.0268962
France G, Volianskis R, Ingram R, Bannister N, Rothärmel R, Irvine MW, Fang G, Burnell ES, Sapkota K, Costa BM, Chopra DA, Dravid SM,
Michael-Titus AT, Monaghan DT, Georgiou J, Bortolotto ZA, Jane DE, Collingridge GL and Volianskis A (2022).
Differential regulation of STP, LTP and LTD by structurally diverse NMDA receptor subunit-specific positive allosteric modulators. Neuropharmacology vol. 202,
10.1016/j.neuropharm.2021.108840
Brandt MJV, Nijboer CH, Nessel I, Mutshiya TR, Michael‐titus AT, Counotte DS, Schipper L, van der Aa NE, Benders MJNL and de Theije CGM (2022).
Nutritional supplementation reduces lesion size and neuroinflammation in a sex‐dependent manner in a mouse model of perinatal hypoxic‐ischemic brain injury. Nutrients vol. 14, (1)
10.3390/nu140101762021

Guesne S, Connole L, Kim S, Motevalli M, Robson L,
Michael-Titus AT and Sullivan A (2021).
Umbelliferyloxymethyl phosphonate compounds-weakly binding zinc ionophores with neuroprotective properties. Dalton Transactions vol. 50, (46) 17041-17051.
10.1039/d1dt02298a
Ponnusamy V, Ip RTH, Mohamed MAEK, Clarke P, Wozniak E, Mein C, Schwendimann L, Barlas A, Chisholm P, Chakkarapani E,
Michael-Titus AT, Gressens P, Yip PK and Shah DK (2021).
Neuronal let-7b-5p acts through the Hippo-YAP pathway in neonatal encephalopathy. Communications Biology vol. 4, (1)
10.1038/s42003-021-02672-3
Nixon R, Ip THR, Jenkins B, Yip PK, Clarke P, Ponnusamy V,
Michael-Titus AT, Koulman A and Shah DK (2021).
Lipid profiles from dried blood spots reveal lipidomic signatures of newborns undergoing mild therapeutic hypothermia after hypoxic-ischemic encephalopathy. Nutrients vol. 13, (12)
10.3390/nu13124301
Baumard L, Weerts ZZRM, Masclee AAM, Keszthelyi D,
Michael-Titus AT and Peiris M (2021).
Effect of obesity on the expression of nutrient receptors and satiety hormones in the human colon. Nutrients vol. 13, (4)
10.3390/nu130412712020

Gaviria M, Celeghin A,
Michael-Titus AT and
Pallier PN (2020).
Editorial: Brain Plasticity and Contribution of the Emotional Brain to Neural Remodelling After Injury. Frontiers Media Frontiers in Neurology vol. 11, 606271-606271.
10.3389/fneur.2020.606271
Shah DK, Yip PK, Barlas A, Tharmapoopathy P, Ponnusamy V,
Michael-Titus AT and Chisholm P (2020).
Raised Plasma Neurofilament Light Protein Levels After Rewarming Are Associated With Adverse Neurodevelopmental Outcomes in Newborns After Therapeutic Hypothermia. Frontiers in Neurology vol. 11,
10.3389/fneur.2020.562510
Nessel I and
Michael-Titus AT (2020).
Lipid profiling of brain tissue and blood after traumatic brain injury: A review of human and experimental studies. Seminars in Cell and Developmental Biology 10.1016/j.semcdb.2020.08.004
Zirpoli H, Chang CL, Carpentier YA,
Michael-Titus AT, Ten VS and Deckelbaum RJ (2020).
Novel Approaches for Omega-3 Fatty Acid Therapeutics: Chronic Versus Acute Administration to Protect Heart, Brain, and Spinal Cord. Annual Review of Nutrition vol. 40, 161-187.
10.1146/annurev-nutr-082018-124539
Vrettos EI, Valverde IE, Mascarin A,
Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B, Bekas N, Grob NM, Stylos EΚ, Shaye H, Del Borgo M, Aguilar M, Magnani F, Syed N, Crook T, Waqif E, Ghazaly E, Cherezov V, Widdop RE, Luchinat C, Michael‐Titus AT, Mindt TL and Tzakos AG (2020).
Cover Feature: Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity (Chem. Eur. J. 47/2020). Wiley Chemistry - a European Journal vol. 26, (47) 10646-10646.
10.1002/chem.202003569
Vrettos EI, Valverde IE, Mascarin A,
Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B, Bekas N, Grob NM, Stylos E, Shaye H, Del Borgo M, Aguilar M-I, Magnani F, Syed N, Crook T, Waqif E, Ghazaly E, Cherezov V, Widdop RE, Luchinat C,
Michael-Titus AT, Mindt TL and Tzakos A (2020).
Single peptide backbone surrogate mutations to regulate angiotensin GPCR subtype selectivity. Wiley Chemistry: a European Journal 10.1002/chem.202000924
Lilley E, Andrews MR, Bradbury EJ, Elliott H, Hawkins P, Ichiyama RM, Keeley J,
Michael-Titus AT, Moon LDF, Pluchino S, Riddell J, Ryder K and Yip PK (2020).
Refining rodent models of spinal cord injury. Elsevier Experimental Neurology vol. 328,
10.1016/j.expneurol.2020.113273
Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F,
Pallier PN, Brook J, Priestley JV,
Dalli J, Tremoleda JL and
Michael-Titus AT (2020).
A single injection of docosahexaenoic acid induces a pro-resolving lipid mediator profile in the injured tissue and a long-lasting reduction in neurological deficit after traumatic brain injury in mice. Journal of Neurotrauma vol. 37, (1) 66-79.
10.1089/neu.2019.6420
Thau-Zuchman O, Svendsen L, Dyall SC, Paredes-Esquivel U, Rhodes M, Priestley JV, Feichtinger RG, Kofler B, Lotstra S, Martin Verkuyl J, Hageman RJ, Broersen LM, van Wijk N, Silva JP, Tremoleda JL and
Michael-Titus AT (2020).
A new ketogenic formulation improves functional outcome and reduces tissue loss following traumatic brain injury in adult mice. Theranostics vol. 11, (1) 346-360.
10.7150/thno.489952019

Yip PK, Bowes AL, Hall JCE, Burguillos MA, Richard Ip TH, Baskerville T, Liu ZH, Mohamed MAEK, Getachew F, Lindsay AD, Najeeb SUR, Popovich PG, Priestley JV and
Michael-Titus AT (2019).
Docosahexaenoic acid reduces microglia phagocytic activity via miR-124 and induces neuroprotection in rodent models of spinal cord contusion injury. Human Molecular Genetics vol. 28, (14) 2427-2448.
10.1093/hmg/ddz073
Yip PK, Chapman GE, Sillito RR, Ip THR, Akhigbe G, Becker SC, Price AW,
Michael-Titus AT, Armstrong JD and Tremoleda JL (2019).
Studies on long term behavioural changes in group-housed rat models of brain and spinal cord injury using an automated home cage recording system. Journal of Neuroscience Methods vol. 321, 49-63.
10.1016/j.jneumeth.2019.04.005
Thau-Zuchman O, Gomes RN, Dyall SC, Davies M, Priestley JV, Groenendijk M, De Wilde MC, Tremoleda JL and
Michael-Titus AT (2019).
Brain Phospholipid Precursors Administered Post-Injury Reduce Tissue Damage and Improve Neurological Outcome in Experimental Traumatic Brain Injury. Journal of Neurotrauma vol. 36, (1) 25-42.
10.1089/neu.2017.55792018

Adolph M, Calder PC, Deutz NE, Carmona TG, Klek S, Lev S, Mayer K,
Michael-Titus AT, Pradelli L, Puder M, Singer P and Vlaardingerbroek H (2018).
Commentary on Fish Oil-Containing Lipid Emulsions in Adult Parenteral Nutrition: A Review of the Evidence (https://doi.org/10.1177/0148607117721907). Jpen J Parenter Enteral Nutr 10.1002/jpen.1047
Shah DK, Ponnusamy V, Evanson J, Kapellou O, Ekitzidou G, Gupta N, Clarke P,
Michael-Titus AT and Yip PK (2018).
Raised plasma neurofilament light protein levels are associated with abnormal MRI outcomes in newborns undergoing therapeutic hypothermia. Frontiers in Neurology vol. 9, (MAR)
10.3389/fneur.2018.00086
Calder PC, Adolph M, Deutz NE, Grau T, Innes JK, Klek S, Lev S, Mayer K,
Michael-Titus AT, Pradelli L, Puder M, Vlaardingerbroek H and Singer P (2018).
Lipids in the intensive care unit: Recommendations from the ESPEN Expert Group. Clinical Nutrition vol. 37, (1) 1-18.
10.1016/j.clnu.2017.08.0322017

Lopez-Tremoleda J, Alvarez K, ADEN A, DONNAN RS,
MICHAEL-TITUS AT and TOMLINS PH (2017).
Heart-rate sensitive optical coherence angiography for measuring vascular changes due to posttraumatic brain injury in mice. Society of Photo-Optical Instrumentation Engineers Journal of Biomedical Optics vol. 22, (12) 121710-121710.
10.1117/1.JBO.22.12.121710
Lee WLA,
Michael-Titus AT and Shah DK (2017).
Hypoxic-Ischaemic Encephalopathy and the Blood-Brain Barrier in Neonates. Developmental Neuroscience vol. 39, (1-4) 49-58.
10.1159/000467392
Yip PK, Carrillo-Jimenez A, King P, Vilalta A, Nomura K, Chau CC, Egerton AMS, Liu Z-H, Shetty AJ, Tremoleda JL, Davies M, Deierborg T, Priestley JV, Brown GC,
Michael-Titus AT, Venero JL and Burguillos MA (2017).
Galectin-3 released in response to traumatic brain injury acts as an alarmin orchestrating brain immune response and promoting neurodegeneration. Nature Publishing Group Scientific Reports vol. 7, 41689-41689.
10.1038/srep41689
Liu Z-H, Yip PK, Priestley JV and
Michael-Titus AT (2017).
A Single Dose of Docosahexaenoic Acid Increases the Functional Recovery Promoted by Rehabilitation after Cervical Spinal Cord Injury in the Rat. J Neurotrauma vol. 34, (9) 1766-1777.
10.1089/neu.2016.45562016

Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Vadivelu KC, Yip PK, Sosabowski J, Trigg W and
Michael-Titus AT (2016).
In vivo PET imaging of the neuroinflammatory response in rat spinal cord injury using the TSPO tracer [18F]GE-180 and effect of docosahexaenoic acid. European Journal of Nuclear Medicine and Molecular Imaging 10.1007/s00259-016-3391-8
Ponnusamy V, Kapellou O, Yip E, Evanson J, Wong LF,
Michael-Titus A, Yip PK and Shah DK (2016).
A study of microRNAs from dried blood spots in newborns after perinatal asphyxia: A simple and feasible biosampling method. Pediatric Research vol. 79, (5) 799-805.
10.1038/pr.2015.276
Thau-Zuchman O,
Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL and
Michael-Titus AT (2016).
A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury. Brain Injury vol. 30, (5-6) 679-679.
2015

Tremoleda JL, Thau-Zuchman O, Davies M, Foster J, Khan I, Trigg W, Sosabowski J, Mather SJ and
Michael-Titus A (2015).
T-14: IN VIVO IMAGING OF NEUROINFLAMMATION IN NEUROTRAUMA PRECLINICAL MODELS: POTENTIAL FOR CLINICAL TRANSLATION. Shock vol. 44 Suppl 2, 24-25.
10.1097/01.shk.0000472079.77136.27
Liu ZH, Yip PK, Adams L, Davies M, Lee JW, Michael GJ, Priestley JV and
Michael-Titus AT (2015).
A single bolus of docosahexaenoic acid promotes neuroplastic changes in the innervation of spinal cord interneurons and motor neurons and improves functional recovery after spinal cord injury. Journal of Neuroscience vol. 35, (37) 12733-12752.
10.1523/JNEUROSCI.0605-15.2015
Pallier PN, Poddighe L, Zbarsky V, Kostusiak M, Choudhury R, Hart T, Burguillos MA, Musbahi O, Groenendijk M, Sijben JW, deWilde MC, Quartu M, Priestley JV and
Michael-Titus AT (2015).
A nutrient combination designed to enhance synapse formation and function improves outcome in experimental spinal cord injury. Neurobiology of Disease vol. 82, 504-515.
10.1016/j.nbd.2015.09.0072014

Paterniti I, Impellizzeri D, Di Paola R, Esposito E, Gladman S, Yip P, Priestley JV,
Michael-Titus AT and Cuzzocrea S (2014).
Docosahexaenoic acid attenuates the early inflammatory response following spinal cord injury in mice: in-vivo and in-vitro studies. J Neuroinflammation vol. 11,
10.1186/1742-2094-11-62013

Nikolakopoulou Z, Nteliopoulos G,
Michael-Titus AT and Parkinson EK (2013).
Omega-3 polyunsaturated fatty acids selectively inhibit growth in neoplastic oral keratinocytes by differentially activating ERK1/2. Carcinogenesis vol. 34, (12) 2716-2725.
10.1093/carcin/bgt257
Nikolakopoulou Z, Shaikh MH, Dehlawi H,
Michael-Titus AT and Parkinson EK (2013).
The induction of apoptosis in pre-malignant keratinocytes by omega-3 polyunsaturated fatty acids docosahexaenoic acid (DHA) and eicosapentaenoic acid (EPA) is inhibited by albumin. Toxicol Lett vol. 218, (2) 150-158.
10.1016/j.toxlet.2013.01.021
Lim S-N, Gladman SJ, Dyall SC, Patel U, Virani N, Kang JX, Priestley JV and
Michael-Titus AT (2013).
Transgenic mice with high endogenous omega-3 fatty acids are protected from spinal cord injury. Neurobiol Dis vol. 51, 104-112.
10.1016/j.nbd.2012.10.021
Yip PK, Pizzasegola C, Gladman S, Biggio ML, Marino M, Jayasinghe M, Ullah F, Dyall SC, Malaspina A, Bendotti C and
Michael-Titus A (2013).
The omega-3 fatty acid eicosapentaenoic acid accelerates disease progression in a model of amyotrophic lateral sclerosis. Plos One vol. 8, (4)
10.1371/journal.pone.00616262012

Hall JCE, Priestley JV, Perry VH and
Michael-Titus AT (2012).
Docosahexaenoic acid, but not eicosapentaenoic acid, reduces the early inflammatory response following compression spinal cord injury in the rat. J Neurochem vol. 121, (5) 738-750.
10.1111/j.1471-4159.2012.07726.x
Gladman SJ, Huang W, Lim S-N, Dyall SC, Boddy S, Kang JX,
Knight MM, Priestley JV and
Michael-Titus AT (2012).
Improved outcome after peripheral nerve injury in mice with increased levels of endogenous ω-3 polyunsaturated fatty acids. J Neurosci vol. 32, (2) 563-571.
10.1523/JNEUROSCI.3371-11.20122011

Gladman S, Lim SN, Dyall S,
Knight MM, Priestley JV and
Michael-Titus AT (2011).
Omega-3 fatty acids and acute neurological trauma: A perspective on clinical translation. Ocl - Oleagineux Corps Gras Lipides vol. 18, (6) 317-323.
10.1684/ocl.2011.0421
Zbarsky-Barquero⁎ V, Sijben J, De Wilde M, Priestley JV and
Michael-Titus AT (2011).
A multi-nutrient composition with neuroprotective properties in spinal cord injury. Elsevier European Journal of Pharmacology vol. 668, e10-e11.
10.1016/j.ejphar.2011.09.2172010

Jokic N, Yip PK,
Michael-Titus A, Priestley JV and Malaspina A (2010).
The human G93A-SOD1 mutation in a pre-symptomatic rat model of amyotrophic lateral sclerosis increases the vulnerability to a mild spinal cord compression. Springer Bmc Genomics vol. 11, 633-633.
10.1186/1471-2164-11-633
Ward RE, Huang W, Curran OE, Priestley JV and
Michael-Titus AT (2010).
Docosahexaenoic acid prevents white matter damage after spinal cord injury. J Neurotrauma vol. 27, (10) 1769-1780.
10.1089/neu.2010.1348
Malaspina A, Ngoh SFA, Ward RE, Hall JCE, Tai FWD, Yip PK, Jones C, Jokic N, Averill SA,
Michael-Titus AT and Priestley JV (2010).
Activation transcription factor-3 activation and the development of spinal cord degeneration in a rat model of amyotrophic lateral sclerosis. Neuroscience vol. 169, (2) 812-827.
10.1016/j.neuroscience.2010.04.053
Dyall SC, Michael GJ and
Michael-Titus AT (2010).
Omega-3 fatty acids reverse age-related decreases in nuclear receptors and increase neurogenesis in old rats. J Neurosci Res vol. 88, (10) 2091-2102.
10.1002/jnr.22390
Robson LG, Dyall SC, Sidloff D and
Michael-Titus AT (2010).
Omega-3 polyunsaturated fatty acids increase the neurite outgrowth of rat sensory neurones throughout development and in aged animals. Neurobiol Aging vol. 31, (4) 678-687.
10.1016/j.neurobiolaging.2008.05.027
Kiasalari Z, Salehi I, Zhong Y, McMahon SB,
Michael-Titus AT and Michael GJ (2010).
Identification of Perineal Sensory Neurons Activated by Innocuous Heat. J Comp Neurol vol. 518, (2) 137-162.
10.1002/cne.22187
Michael-Titus A, Revest P and Shortland P (2010).
The Nervous System: Systems of the Body Series.
Lim S-N, Huang W, Hall JCE, Ward RE, Priestley JV and
Michael-Titus AT (2010).
The acute administration of eicosapentaenoic acid is neuroprotective after spinal cord compression injury in rats. Prostaglandins Leukot Essent Fatty Acids vol. 83, (4-6) 193-201.
10.1016/j.plefa.2010.08.003
Wann AKT, Mistry J, Blain EJ,
Michael-Titus AT and
Knight MM (2010).
Eicosapentaenoic acid and docosahexaenoic acid reduce interleukin-1β-mediated cartilage degradation. Arthritis Res Ther vol. 12, (6)
10.1186/ar31832009

Huang W, Bhavsar A, Ward RE, Hall JCE, Priestley JV and
Michael-Titus AT (2009).
Arachidonyl trifluoromethyl ketone is neuroprotective after spinal cord injury. J Neurotrauma vol. 26, (8) 1429-1434.
10.1089/neu.2008.0835
Huang WL, Bhavsar A, Ward RE, Hall JCE, Priestley JV and
Michael-Titus AT (2009).
Arachidonyl Trifluoromethyl Ketone Is Neuroprotective after Spinal Cord Injury. J Neurotraum vol. 26, (8) 1429-1434.
10.1089/neu.2008.0835
Michael-Titus AT (2009).
Omega-3 fatty acids: their neuroprotective and regenerative potential in traumatic neurological injury. Clin Lipidol vol. 4, (3) 343-353.
10.2217/CLP.09.192008
Michael-Titus AT, Albert M, Michael GJ, Michaelis T, Watanabe T, Frahm J, Pudovkina O, van der Hart MGC, Hesselink MB, Fuchs E and Czéh B (2008).
SONU20176289, a compound combining partial dopamine D(2) receptor agonism with specific serotonin reuptake inhibitor activity, affects neuroplasticity in an animal model for depression. Eur J Pharmacol vol. 598, (1-3) 43-50.
10.1016/j.ejphar.2008.09.006
Malaspina A and
Michael-Titus AT (2008).
Is the modulation of retinoid and retinoid-associated signaling a future therapeutic strategy in neurological trauma and neurodegeneration? J Neurochem vol. 104, (3) 584-595.
10.1111/j.1471-4159.2007.05071.x2007

Jokic N, Ling YY, Ward RE,
Michael-Titus AT, Priestley JV and Malaspina A (2007).
Retinoid receptors in chronic degeneration of the spinal cord: observations in a rat model of amyotrophic lateral sclerosis. J Neurochem vol. 103, (5) 1821-1833.
10.1111/j.1471-4159.2007.04893.x
Huang WL, King VR, Curran OE, Dyall SC, Ward RE, Lal N, Priestley JV and
Michael-Titus AT (2007).
A combination of intravenous and dietary docosahexaenoic acid significantly improves outcome after spinal cord injury. Brain vol. 130, (Pt 11) 3004-3019.
10.1093/brain/awm223
King VR, Averill SA, Hewazy D, Priestley JV, Torup L and
Michael-Titus AT (2007).
Erythropoietin and carbamylated erythropoietin are neuroprotective following spinal cord hemisection in the rat. Eur J Neurosci vol. 26, (1) 90-100.
10.1111/j.1460-9568.2007.05635.x
Dyall SC, Michael GJ, Whelpton R, Scott AG and
Michael-Titus AT (2007).
Dietary enrichment with omega-3 polyunsaturated fatty acids reverses age-related decreases in the GluR2 and NR2B glutamate receptor subunits in rat forebrain. Neurobiol Aging vol. 28, (3) 424-439.
10.1016/j.neurobiolaging.2006.01.002
Ward RE, Huang W, Hall JCE, Priestley JV and
Michael-Titus AT (2007).
Effect of docosahexaenoic acid on axonal damage after spinal cord injury. Ocl - Oleagineux Corps Gras Lipides vol. 14, (3-4)
10.1051/ocl.2007.0234
Makwana M, Raivich G, Dyall S and
Michael-Titus A (2007).
Effect of docosahexaenoic acid in a mouse facial nerve injury model. Ocl - Oleagineux Corps Gras Lipides vol. 14, (3-4)
10.1051/ocl.2007.0233
Dyall SC, Michael GJ and
Michael-Titus AT (2007).
Omega-3 polyunsaturated fatty acids reverse age-related decreases in retinoic acid receptors, retinoid x receptors and peroxisome-proliferator-activated receptors in rat forebrain. Ocl - Oleagineux Corps Gras Lipides vol. 14, (3-4)
10.1051/ocl.2007.02322006

King VR, Huang WL, Dyall SC, Curran OE, Priestley JV and
Michael-Titus AT (2006).
Omega-3 fatty acids improve recovery, whereas omega-6 fatty acids worsen outcome, after spinal cord injury in the adult rat. J Neurosci vol. 26, (17) 4672-4680.
10.1523/JNEUROSCI.5539-05.2006
Penschuck S, Flagstad P, Didriksen M, Leist M and
Michael-Titus AT (2006).
Decrease in parvalbumin-expressing neurons in the hippocampus and increased phencyclidine-induced locomotor activity in the rat methylazoxymethanol (MAM) model of schizophrenia. Eur J Neurosci vol. 23, (1) 279-284.
10.1111/j.1460-9568.2005.04536.x2004

Flagstad P, Mørk A, Glenthøj BY, van Beek J,
Michael-Titus AT and Didriksen M (2004).
Disruption of neurogenesis on gestational day 17 in the rat causes behavioral changes relevant to positive and negative schizophrenia symptoms and alters amphetamine-induced dopamine release in nucleus accumbens. Neuropsychopharmacology vol. 29, (11) 2052-2064.
10.1038/sj.npp.13005162002

Nazir S, Michael GJ and
Michael-Titus AT (2002).
Distribution of NMDA and AMPA glutamate receptor subunits in rat prefrontal cortex and the effect of chronic imipramine treatment on the GluR2 subunit. Brit J Pharmacol vol. 135,

Hawkins A, McCune L, Whelpton R and
Michael-Titus AT (2002).
Effect of noradrenaline and 5-HT on excitatory amino acid release in rat prefrontal cortex. Brit J Pharmacol vol. 135,
2001

Toner CC, Connell K, Whelpton R, Bains S,
Michael-Titus AT, McLaughlin DP and Stamford JA (2001).
Effects of sevoflurane on dopamine, glutamate and aspartate release in an in vitro model of cerebral ischaemia. Brit J Anaesth vol. 86, (4) 550-554.
10.1093/bja/86.4.5502000

Khan S, Whelpton R and
Michael-Titus AT (2000).
Substance P modulation of striatal dopamine outflow is determined by M1 and M2 muscarinic receptors in male Wistar rats. Neuroscience Letters vol. 293, (3) 179-182.
10.1016/S0304-3940(00)01529-9
Michael-Titus AT, Bains S, Jeetle J and Whelpton R (2000).
Imipramine and phenelzine decrease glutamate overflow in the prefrontal cortex - A possible mechanism of neuroprotection in major depression? Neuroscience vol. 100, (4) 681-684.
10.1016/S0306-4522(00)00390-01999
Michael-Titus AT, Blackburn D, Connolly Y, Priestley JV and Whelpton R (1999).
N-and C-terminal substance P fragments: Differential effects on striatal [3H]substance P binding and NK1 receptor internalization. Neuroreport vol. 10, (10) 2209-2213.
10.1097/00001756-199907130-000381998

Whelpton R,
Michael-Titus AT, Stephens SM, Yau KW and Fengas D (1998).
Identification of substance P metabolites using a combination of reversed-phase high-performance liquid chromatography and capillary electrophoresis. Journal of Chromatography B: Biomedical Applications vol. 716, (1-2) 95-106.
10.1016/S0378-4347(98)00334-X1997

MichaelTitus AT, Whelpton R, Stephens SM and Yau KW (1997).
Metabolism of substance P in rat striatum studies using a combination of high performance liquid chromatography (HPLC) and capillary electrophoresis (CE). Brit J Pharmacol vol. 122, P79-P79.
1996

Khan S, Sandhu J, Whelpton R and MichaelTitus AT (1996).
Substance fragments, SP1-9 and SP6-11, modulate endogenous dopamine outflow in rat striatum. Brit J Pharmacol vol. 119, P175-P175.

Khan S, Whelpton R and
Michael-Titus AT (1996).
Evidence for modulatory effects of substance P fragments (1-4) and (8-11) on endogenous dopamine outflow in rat striatal slices. Neuroscience Letters vol. 205, (1) 33-36.
10.1016/0304-3940(96)12363-6
Khan S, Grogan E, Whelpton R and
Michael-Titus AT (1996).
N- and C-terminal substance P fragments modulate striatal dopamine outflow through a cholinergic link mediated by muscarinic receptors. Neuroscience vol. 73, (4) 919-927.
10.1016/0306-4522(96)00119-41995

KHAN S, GROGAN E, WHELPTON R and MICHAELTITUS AT (1995).
SUBSTANCE-P AND ITS FRAGMENT-(1-7) AND FRAGMENT-(5-11) MODULATE STRIATAL DOPAMINE OUTFLOW VIA A CHOLINERGIC LINK MEDIATED BY MUSCARINIC RECEPTORS. Brit J Pharmacol vol. 116, P96-P96.

Khan S, Brooks N, Whelpton R and
Michael-Titus AT (1995).
Substance P-(1-7) and substance P-(5-11) locally modulate dopamine release in rat striatum. European Journal of Pharmacology vol. 282, (1-3) 229-233.
10.1016/0014-2999(95)00342-I
KHAN S, WHELPTON R and
MICHAEL-TITUS A (1995).
ENDOGENOUS DOPAMINE OUTFLOW FROM RAT STRIATAL SLICES IN STATIC AND DYNAMIC CONDITIONS. Neurosci Res Commun vol. 16, (3) 145-153.

WHELPTON R, MICHAELTITUS AT and YAQUB Z (1995).
TEMOPORFIN BINDING TO HUMAN SERUM-LIPOPROTEINS. Brit J Pharmacol vol. 114, P265-P265.

IRAVANI MM, KHAN S, MICHAELTITUS A, WHELPTON R and KRUK ZL (1995).
EFFECTS OF 6-HYDROXYDOPAMINE LESIONS IN THE VENTRAL TEGMENTAL AREA OR SUBSTANTIA-NIGRA ON DOPAMINE RELEASE IN SUBREGIONS OF THE RAT STRIATUM. Brit J Pharmacol vol. 114, P337-P337.

Whelpton R, Michael‐Titus AT, Basra SS and Grahn M (1995).
DISTRIBUTION OF TEMOPORFIN, A NEW PHOTOSENSITIZER FOR THE PHOTODYNAMIC THERAPY OF CANCER, IN A MURINE TUMOR MODEL. Photochemistry and Photobiology vol. 61, (4) 397-401.
10.1111/j.1751-1097.1995.tb08629.x
Michael‐Titus A, Whelpton R and Yaqub Z (1995).
Binding of temoporfin to the lipoprotein fractions of human serum. British Journal of Clinical Pharmacology vol. 40, (6) 594-597.
10.1111/j.1365-2125.1995.tb05805.x1994

Das D, Rogers J and
Michael-Titus AT (1994).
Comparative study of the effects of mu, delta and kappa opioid agonists on 3H-dopamine uptake in rat striatum and nucleus accumbens. Neuropharmacology vol. 33, (2) 221-226.
10.1016/0028-3908(94)90012-41992

Dourmap N, Michael‐Titus A and Costentin J (1992).
Differential Effect of Intrastriatal Kainic Acid on the Modulation of Dopamine Release by μ‐ and δ‐Opioid Peptides: A Microdialysis Study. Journal of Neurochemistry vol. 58, (2) 709-713.
10.1111/j.1471-4159.1992.tb09775.x1991

Bousselmame R,
Michael-Titus A and Costentin J (1991).
Desensitization of μ-opioid receptors does not modify the analgesia induced by an enkephalinase inhibitor. European Journal of Pharmacology vol. 203, (2) 295-297.
10.1016/0014-2999(91)90728-9
Bousselmame R, Eustache M,
Michael-Titus A and Costentin J (1991).
Chronic inhibition of enkephalinase induces changes in the antinociceptive and locomotor effects of the enkephalinase inhibitor acetorphan in rats. Neuropharmacology vol. 30, (8) 865-870.
10.1016/0028-3908(91)90120-Z1990
Michael-Titus A, Bousselmame R and Costentin J (1990).
Stimulation of dopamine D2 receptors induces an analgesia involving an opiodergic but non enkephalinergic link. European Journal of Pharmacology vol. 187, (2) 201-207.
10.1016/0014-2999(90)90007-S
Costentin J, Duterte-Boucher D, Panissaud C and
Michael-Titus A (1990).
Dopamine D1 and D2 receptors mediate opposite effects of apomorphine on the body temperature of reserpinized mice. Neuropharmacology vol. 29, (1) 31-35.
10.1016/0028-3908(90)90080-B
Dourmap N, Michael‐Titus A and Costentin J (1990).
Acetorphan, an Enkephalinase Inhibitor, Modulates Dopaminergic Transmission in Rat Olfactory Tubercle, but not in the Nucleus Accumbens and Striatum. European Journal of Neuroscience vol. 2, (9) 783-787.
10.1111/j.1460-9568.1990.tb00469.x
Michael-Titus A, Dourmap N, Costentin J and Schwartz JC (1990).
Role of delta opioid receptors in the effects of inhibitors of enkephalin-degrading peptidases on the horizontal and vertical components of locomotion in mice. Neuropeptides vol. 15, (2) 89-100.
10.1016/0143-4179(90)90044-Y1989
Michael-Titus A, Dourmap N and Costentin J (1989).
MU and delta opioid receptors control differently the horizontal and vertical components of locomotor activity in mice. Neuropeptides vol. 13, (4) 235-242.
10.1016/0143-4179(89)90076-0
Michael-Titus A, Dourmap N, Caline H, Costentin J and Schwartz JC (1989).
Role of endogenous enkephalins in locomotion and nociception studied with peptidase inhibitors in two inbred strains of mice (C57BL/6J AND DBA/2J). Neuropharmacology vol. 28, (2) 117-122.
10.1016/0028-3908(89)90046-4
Duterte-Eoucher D, Panissaud C,
Michael-Titus A and Costentin J (1989).
Stimulation of central D1 dopamine receptors reverses reserpine-induced hypothermia in mice. Neuropharmacology vol. 28, (4) 419-421.
10.1016/0028-3908(89)90039-71987
Michael-Titus A, Preterre P, Giros B and Costentin J (1987).
Role of endogenous enkephalins in locomotion evidenced by acetorphan, an 'enkephalinase' inhibitor. Journal of Pharmacology and Experimental Therapeutics vol. 243, (3) 1062-1066.
Michael-Titus A and Costentin J (1987).
Analgesic effects of metapramine and evidence against the involvement of endogenous enkephalins in the analgesia induced by tricyclic antidepressants. Pain vol. 31, (3) 391-400.
10.1016/0304-3959(87)90167-9