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Prof Adrian Hobbs

Adrian Hobbs

Professor of Cardiovascular Pharmacology

William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London
+44 (0)20 7882 5778

www.qmul.ac.uk/whri/people/academic-staff/items/hobbsadrian.html

Research

Interests

Interest in 'lung-on-a-chip' and 'heart-on-a-chip' models; endothelial barrier function Expertise in in vitro studies in human cells from healthy volunteers and patients

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC, Hodivala-Dilke K, Baliga RS and Hobbs AJ (2020). C-type natriuretic peptide co-ordinates cardiac structure and function. European Heart Journal  vol. 41, (9) 1006-1020. 10.1093/eurheartj/ehz093

2019

(2019). Repurposing an anti-cancer agent for the treatment of hypertrophic heart disease. Journal of Pathology  vol. 249, (4) 523-535. 10.1002/path.5340
Hobbs AJ (2019). Nitric oxide biology & pathobiology (3rd edition) editors: Louis Ignarro & Bruce Freeman. Nitric Oxide  vol. 90, 10.1016/j.niox.2018.10.005
Preedy MEJ, Baliga RS and Hobbs AJ (2019). Multiplicity of Nitric Oxide and Natriuretic Peptide Signalling in Heart Failure. Lippincott, Williams & Wilkins  Journal of Cardiovascular Pharmacology  10.1097/FJC.0000000000000724
Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A and Stasch J-P (2019). Correction to: Soluble Guanylate Cyclase Stimulators and Activators. Springer Verlag  Handbook of Experimental Pharmacology  10.1007/164_2019_249
Scott TE, Kemp-Harper BK and Hobbs AJ (2019). Inflammasomes: a novel therapeutic target in pulmonary hypertension? Br J Pharmacol  vol. 176, (12) 1880-1896. 10.1111/bph.14375
Conole D, Myers SH, Mota F, Hobbs AJ and Selwood DL (2019). Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands. Chem Biol Drug Des  vol. 93, (6) 1011-1020. 10.1111/cbdd.13395
Moyes AJ and Hobbs AJ (2019). C-type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature. Int J Mol Sci  vol. 20, (9) 10.3390/ijms20092281
Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K, Maclagan K, Quartly HL, Sofat R, Smit A, Schreiber BE, Coghlan GJ and MacAllister RJ (2019). Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double-blind, placebo-controlled, proof-of-concept trial. Br J Pharmacol  vol. 176, (9) 1251-1267. 10.1111/bph.14621
Sandner P, Zimmer DP, Milne GT, Follmann M, Hobbs A and Stasch J-P (2019). Soluble Guanylate Cyclase Stimulators and Activators. Handb Exp Pharmacol  10.1007/164_2018_197

2018

Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A, Hobbs AJ, Tepper M, White B, Serhan CN, MacAllister R and Gilroy DW (2018). Potent Anti-Inflammatory and Pro-Resolving Effects of Anabasum in a Human Model of Self-Resolving Acute Inflammation. Clinical Pharmacology and Therapeutics  vol. 104, (4) 675-686. 10.1002/cpt.980
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA and Hobbs AJ (2018). Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure. Proc Natl Acad Sci U S A  10.1073/pnas.1800996115
Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese-Krott MM, Bianco CL, Kumagai Y, Hobbs AJ, Lin J, Ida T and Akaike T (2018). Biological hydropersulfides and related polysulfides - a new concept and perspective in redox biology. Febs Lett  vol. 592, (12) 2140-2152. 10.1002/1873-3468.13090
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB, Xiao Q, Townsend-Nicholson A, Hobbs AJ, Ye S and Caulfield MJ (2018). The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. Human Molecular Genetics  vol. 27, (1) 199-210. 10.1093/hmg/ddx375
Barrese V, Stott JB, Figueiredo HB, Aubdool AA, Hobbs AJ, Jepps TA, McNeish AJ and Greenwood IA (2018). Angiotensin II promotes KV7.4 channels degradation through reduced interaction with HSP90 (Heat Shock Protein 90). Hypertension  vol. 71, (6) 1091-1100. 10.1161/HYPERTENSIONAHA.118.11116

2016

Villar IC, Bubb KJ, Moyes AJ, Steiness E, Gulbrandsen T, Levy FO and Hobbs AJ (2016). Functional pharmacological characterization of SER100 in cardiovascular health and disease. Wiley  Br J Pharmacol  10.1111/bph.13634
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield MJ (2016). [OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. J Hypertens  vol. 34 Suppl 2, 10.1097/01.hjh.0000491573.57396.0f
Hobbs AJ (2016). A Janus-Faced Role for Atrial Natriuretic Peptide in Myocardial Infarction? Circ Res  vol. 119, (2) 181-183. 10.1161/CIRCRESAHA.116.309119
Hobbs AJ (2016). Guanylyl cyclase can't stand the HETE. Am J Physiol Heart Circ Physiol  vol. 310, (11) H1608-H1610. 10.1152/ajpheart.00326.2016
(2016). Bile duct-ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences. Liver Int  vol. 36, (6) 837-846. 10.1111/liv.12876
Moyes AJ, Stanford SC, Hosford PS, Hobbs AJ and Ramage AG (2016). Raised arterial blood pressure in neurokinin-1 receptor-deficient mice ( NK1R −/− ): evidence for a neural rather than a vascular mechanism. Experimental Physiology  vol. 101, (5) 588-598. 10.1113/EP085347
Oettrich JM, Dao VT, Frijhoff J, Kleikers PWM, Casas AI, Hobbs AJ and Schmidt HHHW (2016). Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology. Clinical Pharmacology & Therapeutics  vol. 99, (4) 360-362. 10.1002/cpt.336
Sand CA and Hobbs AJ (2016). The nuances of NO synthase regulation in sepsis: Could targeting BH4 be the answer? Vascul Pharmacol  vol. 77, 35-37. 10.1016/j.vph.2015.10.008

2015

Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM, Hobbs AJ and Chowdhury TT (2015). C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes. Biochemical and Biophysical Research Communications  vol. 465, (4) 784-789. 10.1016/j.bbrc.2015.08.087
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A, Xiao Q, Hobbs A, Ye S and Caulfield M (2015). Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. Journal of Human Hypertension  vol. 29, (10) 624-624.
Papapetropoulos A, Hobbs AJ and Topouzis S (2015). Extending the translational potential of targeting NO/cGMP-regulated pathways in the CVS. Br J Pharmacol  vol. 172, (6) 1397-1414. 10.1111/bph.12980
(2015). Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage Explants. American Chemical Society  Biomacromolecules  10.1021/bm501575w

2014

Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ, Hobbs AJ, Nagy P, Xian M, Lin J and Fukuto JM (2014). Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility. Free Radic Biol Med  vol. 77, 82-94. 10.1016/j.freeradbiomed.2014.09.007
Peake NJ, Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F and Chowdhury TT (2014). Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function. Osteoarthritis Cartilage  vol. 22, (11) 1800-1807. 10.1016/j.joca.2014.07.018
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock A-S, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL, Ahluwalia A and Hobbs AJ (2014). Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest  vol. 124, (9) 4039-4051. 10.1172/JCI74281
Bubb KJ, Trinder SL, Baliga RS, Patel J, Clapp LH, MacAllister RJ and Hobbs AJ (2014). Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension. Circulation  vol. 130, (6) 496-507. 10.1161/CIRCULATIONAHA.114.009751
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ and Hobbs AJ (2014). Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol  vol. 171, (14) 3463-3475. 10.1111/bph.12694
Hobbs AJ (2014). Natriuretic peptide receptors and heart failure: to B or not to B blocked? Naunyn Schmiedebergs Arch Pharmacol  vol. 387, (1) 1-4. 10.1007/s00210-013-0946-0
Gonzales MA, Han H, Moyes A, Radinos A, Hobbs AJ, Coombs N, Oliver SRJ and Mascharak PK (2014). Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex. Journal of Materials Chemistry B  vol. 2, (15) 2107-2113. 10.1039/c3tb21309a

2013

Derrett-Smith EC, Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM, Hobbs AJ, Abraham D and Denton CP (2013). Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis Rheum  vol. 65, (11) 2928-2939. 10.1002/art.38078
Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M, Castello L, Calvieri C, Eberini I, Sadoshima J, Hobbs AJ, Volpe M and Rubattu S (2013). C2238 Atrial Natriuretic Peptide Molecular Variant Is Associated With Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling. Circulation Research  vol. 112, (10) 1355-+. 10.1161/CIRCRESAHA.113.301325
Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S, Yousuf M, Benjamin N, Webb AJ, Caulfield MJ, Hobbs AJ and Ahluwalia A (2013). Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential. Hypertension  vol. 61, (5) 1091-1102. 10.1161/HYPERTENSIONAHA.111.00933
Ahluwalia A and Hobbs AJ (2013). Letter by Ahluwalia and Hobbs Regarding Article, Nitrate-Nitrite-Nitric Oxide Pathway in Pulmonary Arterial Hypertension Therapeutics. Circulation  vol. 127, (2) E275-E275. 10.1161/CIRCULATIONAHA.112.118356
Baliga RS, Macallister RJ and Hobbs AJ (2013). Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application. Handb Exp Pharmacol  vol. 218, 477-511. 10.1007/978-3-642-38664-0_19
Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ, Hobbs AJ and Chowdhury TT (2013). Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D / bioreactor model. Bio Med Central  Arthritis Research and Therapy  vol. 15, (4) 10.1186/ar4253

2012

Moyes AJ, Khambata RS, Ahluwalia A and Hobbs AJ (2012). Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide. Circulation  vol. 126, (21)
Chan MV, Bubb KJ, Noyce A, Villar IC, Duchene J, Hobbs AJ, Scotland RS and Ahluwalia A (2012). Distinct endothelial pathways underlie sexual dimorphism in vascular auto-regulation. Br J Pharmacol  vol. 167, (4) 805-817. 10.1111/j.1476-5381.2012.02012.x
Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ, Ahluwalia A and Hobbs AJ (2012). Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase. Circulation  vol. 125, (23) 2922-2932. 10.1161/CIRCULATIONAHA.112.100586
Gonzalez MA, Yim MA, Cheng S, Moyes A, Hobbs AJ and Mascharak PK (2012). Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide-Releasing Molecules. Inorganic Chemistry  vol. 51, (1) 601-608. 10.1021/ic2021287

2011

Khambata RS, Panayiotou CM and Hobbs AJ (2011). Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide. Br J Pharmacol  vol. 164, (2b) 584-597. 10.1111/j.1476-5381.2011.01400.x
Pourcet B, Feig JE, Vengrenyuk Y, Hobbs AJ, Kepka-Lenhart D, Garabedian MJ, Morris SM, Fisher EA and Pineda-Torra I (2011). LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ Res  vol. 109, (5) 492-501. 10.1161/CIRCRESAHA.111.241810
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL, Perretti M, Hobbs AJ and Ahluwalia A (2011). Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin. Arterioscler Thromb Vasc Biol  vol. 31, (5) 1075-1083. 10.1161/ATVBAHA.111.223545
Baliga RS, MacAllister RJ and Hobbs AJ (2011). New perspectives for the treatment of pulmonary hypertension. Br J Pharmacol  vol. 163, (1) 125-140. 10.1111/j.1476-5381.2010.01164.x
Gonzalez MA, Fry NL, Burt R, Davda R, Hobbs A and Mascharak PK (2011). Designed Iron Carbonyls as Carbon Monoxide (CO) Releasing Molecules: Rapid CO Release and Delivery to Myoglobin in Aqueous Buffer, and Vasorelaxation of Mouse Aorta. Inorg Chem  vol. 50, (7) 3127-3134. 10.1021/ic2000848
Kapil V, Benjamin N, Hobbs A and Ahluwalia A (2011). Response to Inorganic Nitrate for Blood Pressure Lowering? Hypertension  vol. 57, (2) E3-E3. 10.1161/HYPERTENSIONAHA.110.164814

2010

Derrett-Smith EC, Dooley A, Baliga R, Hobbs A, MacAllister R, Abraham D and Denton CP (2010). Perturbed VEGF signalling within the pulmonary vasculature of a TGF beta dependent mouse model of systemic sclerosis. Clin Exp Rheumatol  vol. 28, (5) S63-S63.
Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W, Hobbs AJ, Shattock MJ and Eaton P (2010). Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. Am J Physiol-Heart C  vol. 299, (3) H827-H836. 10.1152/ajpheart.00129.2010
Panayiotou CM, Baliga R, Stidwill R, Taylor V, Singer M and Hobbs AJ (2010). Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A. Br J Pharmacol  vol. 160, (8) 2045-2054. 10.1111/j.1476-5381.2010.00830.x
Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R, Hobbs AJ, Webb AJ and Ahluwalia A (2010). Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension  vol. 56, (2) 274-281. 10.1161/HYPERTENSIONAHA.110.153536
Khambata RS, Panayiotou CM, Xiao F and Hobbs AJ (2010). The anti-atherogenic potential of C-type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor-C. Faseb Journal  vol. 24,
Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ, Cuzzocrea S, Hobbs AJ, Thiemermann C and Ahluwalia A (2010). Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. Nitric Oxide-Biol Ch  vol. 22, (2) 141-148. 10.1016/j.niox.2009.10.010
Lumsden NG, Khambata RS and Hobbs AJ (2010). C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target. Curr Pharm Design  vol. 16, (37) 4080-4088.
Lumsden NG, Khambata RS and Hobbs AJ (2010). C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target. Curr Pharm Des  vol. 16, (37) 4080-4088. 10.2174/138161210794519237

2009

Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P, Marrelli A, Pitzalis C, Cipollone F, Schanstra J, Bascands J-L, Hobbs AJ, Perretti M and Ahluwalia A (2009). Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol  vol. 29, (11) 1757-1763. 10.1161/ATVBAHA.109.191775
Miller TW, Cherney MM, Lee AJ, Francoleon NE, Farmer PJ, King SB, Hobbs AJ, Miranda KM, Burstyn JN and Fukuto JM (2009). The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS. J Biol Chem  vol. 284, (33) 21788-21796. 10.1074/jbc.M109.014282
Kapil V, Rehman F, Arghandawi S, Milsom A, Benjamin N, Hobbs A, MacAllister R, Webb A and Ahluwalia A (2009). BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE. Basic Clin Pharmacol  vol. 105, 31-31.
Morris T, Stables M, Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G and Gilroy DW (2009). Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans. J Immunol  vol. 183, (3) 2089-2096. 10.4049/jimmunol.0900477
Okorie M, Akram F, Loukogeorgakis S, Webb A, Deanfield J, Benjamin N, Hobbs A, MacAllister R and Ahluwalia A (2009). ORAL INORGANIC NITRATE PROTECTS AGAINST ENDOTHELIAL ISCHAEMIA-REPERFUSION INJURY IN HUMANS. Basic Clin Pharmacol  vol. 105, 26-26.
Hajihosseini MK, Ramasamy S, De Langhe S, Lana-Elola E, Rice D, Rio LQ, Kelly R, Sharpe J and Bellusci S (2009). Involvement of Fibroblast growth factor 10 (Fgf10) in the anterior-posterior patterning and specification of muscle and tendon progenitors in the developing mouse limbs. Faseb Journal  vol. 23,
Hobbs AJ, Gane P, Lumsden N, Nobles M, Rebstock A-S, Simone M, Villar I, Worthington R, Xiao F, Ahluwalia A and Selwood D (2009). Design and development of novel non-peptide agonists at natriuretic peptide receptor-C. Faseb Journal  vol. 23,
Diller GP, Bedard E, Wort SJ, Gatzoulis MA, van Eijl S, Ali O, Wilkins MR, Wharton J, Okonko DO, Howard LS, Thum T, Bauersachs J, Gibbs JSR and Hobbs AJ (2009). Response to Letter Regarding Article, Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension. Circulation  vol. 119, (9) E231-E231. 10.1161/CIRCULATIONAHA.108.816363

2008

Webb AJ, Milsom AB, Rathod KS, Chu WL, Qureshi S, Lovell MJ, Lecomte FMJ, Perrett D, Raimondo C, Khoshbin E, Ahmed Z, Uppal R, Benjamin N, Hobbs AJ and Ahluwalia A (2008). Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. Circ Res  vol. 103, (9) 957-964. 10.1161/CIRCRESAHA.108.175810
Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ and Hobbs AJ (2008). Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. Am J Respir Crit Care Med  vol. 178, (8) 861-869. 10.1164/rccm.200801-121OC
Marro ML, Peiro C, Panayiotou CM, Baliga RS, Meurer S, Schmidt HHHW and Hobbs AJ (2008). Characterization of the human alpha(1)beta(1) soluble guanylyl cyclase promoter - Key role for NF-kappa B(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor. J Biol Chem  vol. 283, (29) 20027-20036. 10.1074/jbc.M801223200
Diller GP, van Eijl S, Okonko DO, Howard LS, Ali O, Thum T, Wort SJ, Bedard E, Gibbs JSR, Bauersachs J, Hobbs AJ, Wilkins MR, Gatzoulis MA and Wharton J (2008). Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. Circulation  vol. 117, (23) 3020-3030. 10.1161/CIRCULATIONAHA.108.769646
Villar IC, Hobbs AJ and Ahluwalia A (2008). Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. J Endocrinol  vol. 197, (3) 447-462. 10.1677/JOE-08-0070
(2008). Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN gamma-dependent iNOS expression in the vasculature of healthy mice. Blood  vol. 111, (10) 5187-5194. 10.1182/blood-2007-10-117283
Panayiotou CM, Stidwill R, Taylor V, Singer M and Hobbs AJ (2008). Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A. Faseb Journal  vol. 22,
Webb A, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin B, Macallister R, Hobbs A and Abluwalia A (2008). Acute blood pressure lowering and vasoprotective effects of dietary nitrate. Faseb Journal  vol. 22,
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R, Hobbs AJ and Ahluwalia A (2008). Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension  vol. 51, (3) 784-790. 10.1161/HYPERTENSIONAHA.107.103523

2007

Villar IC, Panayiotou CM, Sheraz A, Madhani M, Scotland RS, Nobles M, Kemp-Harper B, Ahluwalia A and Hobbs AJ (2007). Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. Cardiovasc Res  vol. 74, (3) 515-525. 10.1016/j.cardiores.2007.02.032
Paolocci N, Jackson MI, Lopez BE, Miranda K, Tocchetti CG, Wink DA, Hobbs AJ and Fukuto JM (2007). The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO. Pharmacology & Therapeutics  vol. 113, (2) 442-458. 10.1016/j.pharmthera.2006.11.002

2006

Madhani M, Patra AK, Miller TW, Eroy-Reveles AA, Hobbs AJ, Fukuto JM and Mascharak PK (2006). Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta. J Med Chem  vol. 49, (25) 7325-7330. 10.1021/jm0604629
Madhani M, Okorie M, Hobbs AJ and MacAllister RJ (2006). Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo. Br J Pharmacol  vol. 149, (6) 797-801. 10.1038/sj.bjp.0706920
Villar IC, Ahluwalia A and Hobbs AJ (2006). Distinct pathways regulate endothelium derived hyperpolarising factor-mediated responses in rat mesenteric arteries. Acta Pharmacol Sin  vol. 27, (9) 1276-1276.
Villar IC, Francis S, Webb A, Hobbs AJ and Ahluwalia A (2006). Novel aspects of endothelium-dependent regulation of vascular tone. Kidney Int  vol. 70, (5) 840-853. 10.1038/sj.ki.5001680
Marro M, Panayiotou C and Hobbs A (2006). Vascular inflammation modulates alpha 1 and beta 1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells (HASMCs). Acta Pharmacol Sin  vol. 27, 172-172.
Panayiotou CM and Hobbs AJ (2006). C-Type natriuretic peptide mediates ERK1/2 phosphorylation via Gi-coupled natriuretic peptide receptor-C in rat aortic smooth muscle cells. Acta Pharmacol Sin  vol. 27, 170-170.

2005

Scotland RS, Cohen M, Foster P, Lovell M, Mathur A, Ahluwalia A and Hobbs AJ (2005). C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression. P Natl Acad Sci Usa  vol. 102, (40) 14452-14457. 10.1073/pnas.0504961102
Connelly L, Madhani M and Hobbs AJ (2005). Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo. J Biol Chem  vol. 280, (11) 10040-10046. 10.1074/jbc.M411991200
Ahluwalia A and Hobbs AJ (2005). Endothelium-derived C-type natriuretic peptide: more than just a hyperpolarizing factor. Trends Pharmacol Sci  vol. 26, (3) 162-167. 10.1016/j.tips.2005.01.005
Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H, Hobbs AJ and Ahluwalia A (2005). Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice - Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation  vol. 111, (6) 796-803. 10.1161/01.CIR.0000155238.70797.4E
Scotland RS, Ahluwalia A and Hobbs AJ (2005). C-type natniuretic peptide in vascular physiology and disease. Pharmacol Therapeut  vol. 105, (2) 85-93. 10.1016/j.pharmthera.2004.08.011

2004

Chauhan SD, Hobbs AJ and Ahluwalia A (2004). C-type natriuretic peptide: new candidate for endothelium-derived hyperpolarising factor. Int J Biochem Cell Biol  vol. 36, (10) 1878-1881. 10.1016/j.biocel.2003.09.009
Hobbs A, Foster P, Prescott C, Scotland R and Ahluwalia A (2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury - Novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation  vol. 110, (10) 1231-1235. 10.1161/01.CIR.0000141802.29945.34
Ahluwalia A, MacAllister RJ and Hobbs AJ (2004). Vascular actions of natriuretic peptides. Cyclic GMP-dependent and -independent mechanisms. Basic Res Cardiol  vol. 99, (2) 83-89. 10.1007/s00395-004-0459-6
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A, Perretti M, Moncada S and Hobbs AJ (2004). Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. P Natl Acad Sci Usa  vol. 101, (5) 1386-1391. 10.1073/pnas.0304264101
AHLUWALIA A, Hobbs A, Prescott C, Scotland R and Foster P (2004). Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation  vol. 110, (10) 1231-1235. 10.1161/01.CIR.0000141802.29945.34

2003

Hobbs AJ and Moncada S (2003). Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272. Vascul Pharmacol  vol. 40, (3) 149-154. 10.1016/s1537-1891(03)00046-6
Madhani M, Scotland RS, MacAllister RJ and Hobbs AJ (2003). Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling. Br J Pharmacol  vol. 139, (7) 1289-1296. 10.1038/sj.bjp.0705365
Connelly L, Jacobs AT, Palacios-Callender M, Moncada S and Hobbs AJ (2003). Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. J Biol Chem  vol. 278, (29) 26480-26487. 10.1074/jbc.M302238200
Chauhan SD, Nilsson H, Ahluwalia A and Hobbs AJ (2003). Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. P Natl Acad Sci Usa  vol. 100, (3) 1426-1431. 10.1073/pnas.0336365100
Kalsi JS, Rees RW, Hobbs AJ, Royle M, Kell PD, Ralph DJ, Moncada S and Cellek S (2003). BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro. J Urol  vol. 169, (2) 761-766. 10.1097/01.ju.0000043880.58140.69
AHLUWALIA A, Hobbs AJ, Seggara G, Chauhan SD, Vo PA and MacAllister RJ (2003). Protection against liposaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. Faseb J  vol. 17, (6) 773-775. 10.1096/fj.02-0668fje

2002

Hobbs AJ, Gladwin MT, Patel RP, Williams DLH and Butler AR (2002). Haemoglobin: NO transporter, NO inactivator or NOne of the above? Trends Pharmacol Sci  vol. 23, (9) 406-411. 10.1016/s0165-6147(02)02067-9
Hobbs AJ, Gladwin MT, Patel RP, Williams DLH and Butler AR (2002). Haernoglobin: NO transporter, NO inactivator or NOne of the above? Trends Pharmacol Sci  vol. 23, (9) 406-411. 10.1016/S0165-6147(02)02067-9
Hobbs AJ (2002). Soluble guanylate cyclase: an old therapeutic target re-visited. Br J Pharmacol  vol. 136, (5) 637-640. 10.1038/sj.bjp.0704779
Chauhan SD, MacAllister RJ, Hobbs AJ and Ahluwalia A (2002). Mechanisms underlying the vasorelaxant activity of C-type natriuretic peptide (CNP) in rat mesenteric resistance arteries. Faseb J  vol. 16, (4) A572-A572.

2001

Connelly L, Palacios-Callender M, Ameixa C, Moncada S and Hobbs AJ (2001). Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide. J Immunol  vol. 166, (6) 3873-3881. 10.4049/jimmunol.166.6.3873
Hussain MB, MacAllister RJ and Hobbs AJ (2001). Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases. Am J Physiol Heart Circ Physiol  vol. 280, (3) H1151-H1159. 10.1152/ajpheart.2001.280.3.H1151
Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC, Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G and Woo CK (2001). Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J Med Chem  vol. 44, (1) 78-93. 10.1021/jm001034k

2000

Shah S, Hobbs A, Singh R, Cuevas J, Ignarro LJ and Chaudhuri G (2000). Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves. American Journal of Physiology-Regulatory Integrative and Comparative Physiology  vol. 279, (4) R1478-R1485. 10.1152/ajpregu.2000.279.4.R1478
Cavero M, Hobbs A, Madge D, Motherwell WB, Selwood D and Potier P (2000). Synthesis and biological evaluation of enantiopure thionitrites: the solid-phase synthesis and nitrosation of D-glutathione as a molecular probe. Bioorg Med Chem Lett  vol. 10, (7) 641-644. 10.1016/s0960-894x(00)00060-3
Hussain MB, MacAllister RJ and Hobbs AJ (2000). Regulation of cGMP-mediated vasorelaxation in mouse thoracic aorta: Interactions of the soluble and particulate guanylate cyclases. Brit J Pharmacol  vol. 129,

1999

Hussain MB, Hobbs AJ and MacAllister RJ (1999). Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta. Br J Pharmacol  vol. 128, (5) 1082-1088. 10.1038/sj.bjp.0702874
Wolzt M, MacAllister RJ, Davis D, Feelisch M, Moncada S, Vallance P and Hobbs AJ (1999). Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity. J Biol Chem  vol. 274, (41) 28983-28990. 10.1074/jbc.274.41.28983
Hussain MB, Hobbs AJ and MacAllister RJ (1999). Enhanced sensitivity of the soluble guanylate cyclase/cyclic GMP system in the eNOS knockout mouse. Brit J Pharmacol  vol. 126, U41-U41.
Hobbs AJ, Higgs A and Moncada S (1999). Inhibition of nitric oxide synthase as a potential therapeutic target. Annu Rev Pharmacol Toxicol  vol. 39, 191-220. 10.1146/annurev.pharmtox.39.1.191

1997

Hobbs AJ (1997). Soluble guanylate cyclase: the forgotten sibling. Trends Pharmacol Sci  vol. 18, (12) 484-491. 10.1016/s0165-6147(97)01137-1

1996

Cohen GA, Hobbs AJ, Fitch RM, Zinner MJ, Chaudhuri G and Ignarro LJ (1996). Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo. Am J Physiol  vol. 271, (1 Pt 2) H133-H139. 10.1152/ajpheart.1996.271.1.H133
Hobbs AJ and Ignarro LJ (1996). Nitric oxide cyclic GMP signal transduction system. Nitric Oxide, Pt B  vol. 269, 134-148. 10.1016/s0076-6879(96)69016-8

1995

SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, IGNARRO LJ, ASHLEY SW and CHAUDHURI G (1995). ENHANCED ACTIONS OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE FUNCTION DURING PREGNANCY. Gastroenterology  vol. 108, (4) A1246-A1246. 10.1016/0016-5085(95)29278-0
SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ and CHAUDHURI G (1995). CHANGES IN GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY MAY BE INDUCED BY NITRIC-OXIDE. Gastroenterology  vol. 108, (4) A688-A688. 10.1016/0016-5085(95)27063-9
HOBBS AJ, COHEN GA, FITCH RM, YIN TL, CHAUDHURI G and IGNARRO LJ (1995). DIFFERENTIAL INHIBITORY EFFECT OF L-NAME ON ENDOTHELIUM-DEPENDENT RELAXATION IN-VITRO AND IN-VIVO. Faseb Journal  vol. 9, (3) A328-A328.
SHAH SN, CUEVAS JM, HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ and CHAUDHURI G (1995). THE ROLE OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY. Faseb Journal  vol. 9, (3) A86-A86.
COHEN GA, HOBBS AJ, FITCH RM, ASHLEY SW, CRYER MH, CHAUDHURI G and IGNARRO LJ (1995). STIMULATED RELEASE OF NITRIC-OXIDE (NO) IS LINKED TO ALPHA-ADRENOCEPTOR ACTIVATION IN-VIVO. Faseb Journal  vol. 9, (3) A328-A328.
Griscavage JM, Hobbs AJ and Ignarro LJ (1995). Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds. Adv Pharmacol  vol. 34, 215-234. 10.1016/s1054-3589(08)61088-1

1994

HOBBS AJ, FUKUTO JM and IGNARRO LJ (1994). FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE - DIRECT ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE. Proceedings of The National Academy of Sciences of The United States of America  vol. 91, (23) 10992-10996. 10.1073/pnas.91.23.10992
HOBBS AJ, GRISCAVAGE JM, ROGERS NE, BYRNS RE, FUKUTO JM and IGNARRO LJ (1994). FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE. Faseb Journal  vol. 8, (4) A360-A360.

1993

Fukuto JM, Hobbs AJ and Ignarro LJ (1993). Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO. Biochem Biophys Res Commun  vol. 196, (2) 707-713. 10.1006/bbrc.1993.2307
Brave SR, Bhat S, Hobbs AJ, Tucker JF and Gibson A (1993). The influence of L-NG-nitro-arginine on sympathetic nerve induced contraction and noradrenaline release in the rat isolated anococcygeus muscle. J Auton Pharmacol  vol. 13, (3) 219-225. 10.1111/j.1474-8673.1993.tb00269.x

1992

Gibson A, Babbedge R, Brave SR, Hart SL, Hobbs AJ, Tucker JF, Wallace P and Moore PK (1992). An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus. Br J Pharmacol  vol. 107, (3) 715-721. 10.1111/j.1476-5381.1992.tb14512.x

1991

Hobbs AJ, Tucker JF and Gibson A (1991). Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions. Br J Pharmacol  vol. 104, (3) 645-650. 10.1111/j.1476-5381.1991.tb12483.x
Brave SR, Hobbs AJ, Gibson A and Tucker JF (1991). The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle. Biochem Biophys Res Commun  vol. 179, (2) 1017-1022. 10.1016/0006-291x(91)91920-8
Mirzazadeh S, Hobbs AJ, Tucker JF and Gibson A (1991). Cyclic nucleotide content of the rat anococcygeus during relaxations induced by drugs or by non-adrenergic, non-cholinergic field stimulation. J Pharm Pharmacol  vol. 43, (4) 247-251. 10.1111/j.2042-7158.1991.tb06677.x

1990

Hobbs AJ and Gibson A (1990). L-NG-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus. Br J Pharmacol  vol. 100, (4) 749-752. 10.1111/j.1476-5381.1990.tb14086.x
Tucker JF, Brave SR, Charalambous L, Hobbs AJ and Gibson A (1990). L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle. Br J Pharmacol  vol. 100, (4) 663-664. 10.1111/j.1476-5381.1990.tb14072.x
Gibson A, Mirzazadeh S, Hobbs AJ and Moore PK (1990). L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle. Br J Pharmacol  vol. 99, (3) 602-606. 10.1111/j.1476-5381.1990.tb12976.x

Grants

Grants of specific relevance to Predictive in vitro Models
Delineating physiological and pathological regulatory roles for C-type natriuretic peptide in cardiac structure and function
Hobbs AJ
£817,911 British Heart Foundation (01-03-2017 - 28-02-2022)
Abstract
Characterisation of the physiological roles and pathological significance of endothelium-derived C-type natriuretic peptide: a novel vasoprotective signalling paradigm.
Hobbs AJ, Ahluwalia A and Tinker A
£476,952 Wellcome Trust (04-11-2008 - 03-07-2011)
Abstract


Design and development of novel non-peptide agonists at the natriuretic peptide receptor-C and evaluation of therapeutic potential for cardiovascular disease
Hobbs AJ, Ahluwalia A, Madge DJ and Selwood DL
£733,988 Wellcome Trust (09-01-2006 - 08-03-2009)
Abstract
Characterisation of C-type natriuretic peptide (CNP) as an endothelium-derivedhyperpolarising factor: regulation of vascular tone, and platelet reactivity.
Hobbs AJ, Ahluwalia A, Leaney JL and Scotland RS
£130,460 Wellcome Trust (01-04-2003 - 31-05-2005)
Abstract
Design and development of novel non-peptide agonists at the natriuretic peptide receptor-C and evaluation of therapeutic potential for cardiovascular disease
Hobbs AJ, Ahluwalia A and Madge DJ
£50,000 Wellcome Trust (01-12-2004 - 30-11-2005)
Abstract
Intravital microscopy set up.
Ahluwalia A, Hobbs AJ and Vallance PJ
£71,208 Wellcome Trust (01-07-2001 - 30-09-2002)
Abstract