Publications
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Publications of specific relevance to Predictive in vitro Models
2023
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Christie IN, Theparambil SM, Braga A, Doronin M, Hosford PS, Brazhe A, Mascarenhas A, Nizari S, Hadjihambi A, Wells JA,
Hobbs A, Semyanov A, Abramov AY, Angelova PR and Gourine AV (2023).
Astrocytes produce nitric oxide via nitrite reduction in mitochondria to regulate cerebral blood flow during brain hypoxia. Elsevier Cell Reports vol. 42, (12)
10.1016/j.celrep.2023.113514![](/publications/bullet24.png)
Aubdool AA, Moyes AJ, Perez-Ternero C, Tsui JC, Lu HS, Daugherty A and
Hobbs AJ (2023).
Abstract 15171: Endothelium-Derived C-Type Natriuretic Peptide Prevents the Development and Progression of Abdominal Aortic Aneurysm. Wolters Kluwer Circulation vol. 148, (Suppl_1)
10.1161/circ.148.suppl_1.15171![](/publications/bullet24.png)
Alexander SPH, Fabbro D, Kelly E, Mathie AA, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Davies JA, Beuve A, Brouckaert P, Bryant C, Burnett JC, Farndale RW, Friebe A, Garthwaite J,
Hobbs AJ, Jarvis GE, Koesling D, Kuhn M, MacEwan D, Monie TP, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA (2023).
The Concise Guide to PHARMACOLOGY 2023/24: Catalytic receptors. Wiley British Journal of Pharmacology vol. 180, (S2) s241-s288.
10.1111/bph.16180![](/publications/bullet24.png)
Fato BR, de Alwis N,
Hobbs AJ, Kaitu'u-Lino TJ, Bubb KJ and Hannan NJ (2023).
PO3_08. C-type natriuretic peptide relaxes omental arteries in a new ex vivo model of preeclampsia. Elsevier Pregnancy Hypertension vol. 33,
10.1016/j.preghy.2023.07.048![](/publications/bullet24.png)
Andresen H, Pérez‐Ternero C, Robinson J, Dickey DM,
Hobbs AJ, Potter LR, Levy FO, Cataliotti A and Moltzau LR (2023).
Novel enhancers of guanylyl cyclase‐A activity acting via allosteric modulation. Wiley British Journal of Pharmacology vol. 180, (24) 3254-3270.
10.1111/bph.16203![](/publications/bullet24.png)
Dignam JP, Perez-Ternero C, Aubdool AA and
Hobbs AJ (2023).
C-Type Natriuretic Peptide Signalling Attenuates the Development of Pulmonary Hypertension and Right Ventricular Remodelling.![](/publications/bullet24.png)
Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J,
Hobbs AJ, Koesling D, Kuhn M, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA (2023).
Receptor guanylyl cyclase (RGC) family in GtoPdb v.2023.1. University of Edinburgh Iuphar/Bps Guide to Pharmacology Cite vol. 2023, (1)
10.2218/gtopdb/f1022/2023.12022
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Perez-Ternero C,
Pallier PN, Tremoleda JL, Delogu A, Fernandes C,
Michael-Titus AT and
Hobbs AJ (2022).
C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity. Frontiers Frontiers in Molecular Neuroscience vol. 15,
10.3389/fnmol.2022.991112![](/publications/bullet24.png)
Zarenkiewicz J, Perez-Ternero C, Kojasoy V, McGinity C, Khodade VS, Lin J, Tantillo DJ, Toscano JP,
Hobbs AJ and Fukuto JM (2022).
The reaction of hydropersulfides (RSSH) with S-nitrosothiols (RS-NO) and the biological/physiological implications. Elsevier Free Radical Biology and Medicine vol. 188, 459-467.
10.1016/j.freeradbiomed.2022.06.245![](/publications/bullet24.png)
Perez-Ternero C, Aubdool AA, Makwana R, Sanger GJ, Stimson RH,
Chan LF, Moyes AJ and
Hobbs AJ (2022).
C-type natriuretic peptide is a pivotal regulator of metabolic homeostasis. Proc Natl Acad Sci U S A vol. 119, (13)
10.1073/pnas.2116470119![](/publications/bullet24.png)
Smith RJ, Perez-Ternero C, Conole D, Martin C, Myers SH,
Hobbs AJ and Selwood DL (2022).
A Series of Substituted Bis-Aminotriazines Are Activators of the Natriuretic Peptide Receptor C. American Chemical Society (Acs) Journal of Medicinal Chemistry vol. 65, (7) 5495-5513.
10.1021/acs.jmedchem.1c01974![](/publications/bullet24.png)
Fukuto JM, Perez-Ternero C, Zarenkiewicz J, Lin J,
Hobbs AJ and Toscano JP (2022).
Hydropersulfides (RSSH) and Nitric Oxide (NO) Signaling: Possible Effects on S-Nitrosothiols (RS-NO). Mdpi Antioxidants vol. 11, (1)
10.3390/antiox110101692021
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Scott TE, Qin CX, Drummond GR,
Hobbs AJ and Kemp-Harper BK (2021).
Innovative Anti-Inflammatory and Pro-resolving Strategies for Pulmonary Hypertension: High Blood Pressure Research Council of Australia Award 2019. Hypertension vol. 78, (5) 1168-1184.
10.1161/HYPERTENSIONAHA.120.14525![](/publications/bullet24.png)
Alexander SPH, Fabbro D, Kelly E, Mathie A, Peters JA, Veale EL, Armstrong JF, Faccenda E, Harding SD, Pawson AJ, Southan C, Davies JA, Beuve A, Brouckaert P, Bryant C, Burnett JC, Farndale RW, Friebe A, Garthwaite J,
Hobbs AJ, Jarvis GE, Kuhn M, MacEwan D, Monie TP, Papapetropoulos A, Potter LR, Schmidt HHHW, Szabo C and Waldman SA (2021).
THE CONCISE GUIDE TO PHARMACOLOGY 2021/22: Catalytic receptors. British Journal of Pharmacology vol. 178, (S1) S264-S312.
10.1111/bph.15541![](/publications/bullet24.png)
Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J,
Hobbs AJ, Koesling D, Kuhn M, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA (2021).
Receptor guanylyl cyclase (RGC) family in GtoPdb v.2021.3. Iuphar/Bps Guide to Pharmacology Cite vol. 2021, (3)
10.2218/gtopdb/f1022/2021.3![](/publications/bullet24.png)
Petraina A, Nogales C, Krahn T, Mucke H, Lüscher TF, Fischmeister R, Kass DA, Burnett JC,
Hobbs AJ and Schmidt HHHW (2021).
Cyclic GMP modulating drugs in cardiovascular diseases: mechanism-based network pharmacology. Oxford University Press (Oup) Cardiovascular Research vol. 118, (9) 2085-2102.
10.1093/cvr/cvab240![](/publications/bullet24.png)
Grange RMH, Preedy MEJ, Renukanthan A, Dignam JP, Lowe VJ, Moyes AJ, Pérez‐Ternero C, Aubdool AA, Baliga RS and
Hobbs AJ (2021).
Multidrug resistance proteins preferentially regulate natriuretic peptide‐driven cGMP signalling in the heart and vasculature. Wiley British Journal of Pharmacology vol. 179, (11) 2443-2459.
10.1111/bph.15593![](/publications/bullet24.png)
Dignam JP, Scott TE, Kemp‐Harper BK and
Hobbs AJ (2021).
Animal models of pulmonary hypertension: Getting to the heart of the problem. Wiley British Journal of Pharmacology vol. 179, (5) 811-837.
10.1111/bph.154442020
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Fukuto JM and
Hobbs AJ (2020).
A comparison of the chemical biology of hydropersulfides (RSSH) with other protective biological antioxidants and nucleophiles. Elsevier Nitric Oxide vol. 107, 46-57.
10.1016/j.niox.2020.11.004![](/publications/bullet24.png)
Aziz Q,
Chen J, Moyes AJ, Li Y, Anderson NA, Ang R, Aksentijevic D, Sebastian S,
Hobbs AJ, Thiemermann C and
Tinker A (2020).
Vascular KATP channels protect from cardiac dysfunction and preserve cardiac metabolism during endotoxemia. Springer Science and Business Media Llc Journal of Molecular Medicine 10.1007/s00109-020-01946-3![](/publications/bullet24.png)
Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J,
Hobbs AJ, Koesling D, Kuhn M, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA (2020).
Receptor guanylyl cyclase (RGC) family (version 2020.3) in the IUPHAR/BPS Guide to Pharmacology Database. Iuphar/Bps Guide to Pharmacology Cite vol. 2020, (3)
10.2218/gtopdb/f1022/2020.3![](/publications/bullet24.png)
Armstrong P, Ferreira PM, Chan M, Lundberg Slingsby M, Crescente M, Shih C, Kirkby N,
Hobbs A and Warner T (2020).
Combination of cyclic nucleotide modulators with P2Y12 receptor antagonists as anti-platelet therapy. Wiley Journal of Thrombosis and Haemostasis 10.1111/jth.148262019
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Dukinfield M, Maniati E, Reynolds LE, Aubdool A, Baliga RS, D'Amico G, Maiques O, Wang J, Bedi KC, Margulies KB, Sanz‐Moreno V,
Hobbs A and Hodivala‐Dilke K (2019).
Repurposing an anti‐cancer agent for the treatment of hypertrophic heart disease. Wiley The Journal of Pathology vol. 249, (4) 523-535.
10.1002/path.5340![](/publications/bullet24.png)
Beuve A, Brouckaert P, Burnett JC, Friebe A, Garthwaite J,
Hobbs AJ, Koesling D, Kuhn M, Potter LR, Russwurm M, Schmidt HHHW, Stasch J-P and Waldman SA (2019).
Receptor guanylyl cyclase (RGC) family (version 2019.4) in the IUPHAR/BPS Guide to Pharmacology Database. Iuphar/Bps Guide to Pharmacology Cite vol. 2019, (4)
10.2218/gtopdb/f1022/2019.4![](/publications/bullet24.png)
Preedy MEJ, Baliga RS and
Hobbs AJ (2019).
Multiplicity of Nitric Oxide and Natriuretic Peptide Signalling in Heart Failure. Lippincott, Williams & Wilkins Journal of Cardiovascular Pharmacology 10.1097/FJC.0000000000000724![](/publications/bullet24.png)
Sandner P, Zimmer DP, Milne GT, Follmann M,
Hobbs A and Stasch J-P (2019).
Correction to: Soluble Guanylate Cyclase Stimulators and Activators. Springer Verlag Handbook of Experimental Pharmacology 10.1007/164_2019_249![](/publications/bullet24.png)
Moyes AJ and
Hobbs AJ (2019).
C-Type Natriuretic Peptide: A Multifaceted Paracrine Regulator in the Heart and Vasculature. Mdpi International Journal of Molecular Sciences vol. 20, (9)
10.3390/ijms20092281
Hobbs AJ, Moyes AJ, Baliga RS, Ghedia D, Ochiel R, Sylvestre Y, Doré CJ, Chowdhury K, Maclagan K, Quartly HL, Sofat R, Smit A, Schreiber BE, Coghlan GJ and MacAllister RJ (2019).
Neprilysin inhibition for pulmonary arterial hypertension: a randomized, double‐blind, placebo‐controlled, proof‐of‐concept trial. Wiley British Journal of Pharmacology vol. 176, (9) 1251-1267.
10.1111/bph.14621![](/publications/bullet24.png)
Moyes AJ, Chu SM, Aubdool AA, Dukinfield MS, Margulies KB, Bedi KC,
Hodivala-Dilke K, Baliga RS and
Hobbs AJ (2019).
C-type natriuretic peptide co-ordinates cardiac structure and function. Oxford University Press (Oup) European Heart Journal vol. 41, (9)
10.1093/eurheartj/ehz093![](/publications/bullet24.png)
Sandner P, Zimmer DP, Milne GT, Follmann M,
Hobbs A and Stasch J-P (2019).
Soluble Guanylate Cyclase Stimulators and Activators. Handb Exp Pharmacol 10.1007/164_2018_1972018
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Bubb KJ, Aubdool AA, Moyes AJ, Lewis S, Drayton JP, Tang O, Mehta V, Zachary IC, Abraham DJ, Tsui J and
Hobbs AJ (2018).
Endothelial C-Type Natriuretic Peptide is a Critical Regulator of Angiogenesis and Vascular Remodeling. Circulation 10.1161/CIRCULATIONAHA.118.036344![](/publications/bullet24.png)
Conole D, Myers SH, Mota F,
Hobbs AJ and Selwood DL (2018).
Biophysical screening methods for extracellular domain peptide receptors, application to natriuretic peptide receptor C ligands. Wiley Chemical Biology & Drug Design vol. 93, (6) 1011-1020.
10.1111/cbdd.13395![](/publications/bullet24.png)
Baliga RS, Preedy MEJ, Dukinfield MS, Chu SM, Aubdool AA, Bubb KJ, Moyes AJ, Tones MA and
Hobbs AJ (2018).
Phosphodiesterase 2 inhibition preferentially promotes NO/guanylyl cyclase/cGMP signaling to reverse the development of heart failure. Proc Natl Acad Sci U S A 10.1073/pnas.1800996115![](/publications/bullet24.png)
Scott TE, Kemp‐Harper BK and
Hobbs AJ (2018).
Inflammasomes: a novel therapeutic target in pulmonary hypertension? Wiley British Journal of Pharmacology vol. 176, (12) 1880-1896.
10.1111/bph.14375![](/publications/bullet24.png)
Fukuto JM, Ignarro LJ, Nagy P, Wink DA, Kevil CG, Feelisch M, Cortese‐Krott MM, Bianco CL, Kumagai Y,
Hobbs AJ, Lin J, Ida T and Akaike T (2018).
Biological hydropersulfides and related polysulfides – a new concept and perspective in redox biology. Wiley Febs Letters vol. 592, (12) 2140-2152.
10.1002/1873-3468.13090![](/publications/bullet24.png)
Barrese V, Stott JB, Figueiredo HB, Aubdool AA,
Hobbs AJ, Jepps TA, McNeish AJ and Greenwood IA (2018).
Angiotensin II Promotes KV7.4 Channels Degradation Through Reduced Interaction With HSP90 (Heat Shock Protein 90). Wolters Kluwer Hypertension vol. 71, (6) 1091-1100.
10.1161/hypertensionaha.118.11116![](/publications/bullet24.png)
Motwani MP, Bennett F, Norris PC, Maini AA, George MJ, Newson J, Henderson A,
Hobbs AJ, Tepper M, White B, Serhan CN, MacAllister R and Gilroy DW (2018).
Potent Anti‐Inflammatory and Pro‐Resolving Effects of Anabasum in a Human Model of Self‐Resolving Acute Inflammation. Wiley Clinical Pharmacology & Therapeutics vol. 104, (4) 675-686.
10.1002/cpt.9802017
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Alexander SPH, Kelly E, Marrion NV, Peters JA, Faccenda E, Harding SD, Pawson AJ, Sharman JL, Southan C, Buneman OP, Cidlowski JA, Christopoulos A, Davenport AP, Fabbro D, Spedding M, Striessnig J, Davies JA, Abbracchio MP, Aldrich R, Al-Hosaini K, Arumugam TV, Attali B, Bäck M, Barnes NM, Bathgate R, Beart PM, Becirovic E, Bettler B, Biel M and Birdsall NJ (2017).
THE CONCISE GUIDE TO PHARMACOLOGY 2017/18: Overview. British Journal of Pharmacology vol. 174, S1-S16.
10.1111/bph.13882![](/publications/bullet24.png)
Kapil V (2017).
Abstracts from the 8th International Conference on cGMP Generators, Effectors and Therapeutic Implications : Bamberg, Germany. 23-25 June, 2017. Bmc Pharmacol Toxicol vol. 18, (Suppl 1) 64-64.
10.1186/s40360-017-0170-5![](/publications/bullet24.png)
Ren M, Ng FL, Warren HR, Witkowska K, Baron M, Jia Z, Cabrera C, Zhang R, Mifsud B, Munroe PB,
Xiao Q, Townsend-Nicholson A,
Hobbs AJ, Ye S and Caulfield MJ (2017).
The biological impact of blood pressure-associated genetic variants in the natriuretic peptide receptor C gene on human vascular smooth muscle. Oxford University Press (Oup) Human Molecular Genetics vol. 27, (1) 199-210.
10.1093/hmg/ddx3752016
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Villar IC, Bubb KJ, Moyes AJ, Steiness E, Gulbrandsen T, Levy FO and
Hobbs AJ (2016).
Functional pharmacological characterization of SER100 in cardiovascular health and disease. Wiley Br J Pharmacol 10.1111/bph.13634![](/publications/bullet24.png)
Ren M, Ng F, Witkowska K, Baron M, Townsend-Nicholson A,
Xiao Q,
Hobbs A, Ye S and Caulfield MJ (2016).
[OP.7C.08] BLOOD-PRESSURE ASSOCIATED VARIANTS IN NPR3 AFFECT HUMAN VASCULAR SMOOTH MUSCLE CELLS PROLIFERATION AND CALCIUM RESPONSE TO ANGIOTENSIN II. Wolters Kluwer Journal of Hypertension vol. 34, (&NA;)
10.1097/01.hjh.0000491573.57396.0f![](/publications/bullet24.png)
Chen J, Kieswich J, Chiazza F, Moyes A, Gobbetti T, Purvis G, Salvatori D, Patel N,
Perretti M,
Hobbs A, Collino M, Yaqoob M and THIEMERMANN C (2016).
IkB Kinase Inhibitor Attenuates Sepsis-Induced Cardiac Dysfunction in CKD. American Society of Nephrology Journal of The American Society of Nephrology 10.1681/ASN.2015060670![](/publications/bullet24.png)
Moyes AJ, Stanford SC, Hosford PS,
Hobbs AJ and Ramage AG (2016).
Raised arterial blood pressure in neurokinin-1 receptor-deficient mice ( NK1R −/− ): evidence for a neural rather than a vascular mechanism. Experimental Physiology vol. 101, (5) 588-598.
10.1113/EP085347![](/publications/bullet24.png)
Oettrich JM, Dao VT, Frijhoff J, Kleikers PWM, Casas AI,
Hobbs AJ and Schmidt HHHW (2016).
Clinical Relevance of Cyclic GMP Modulators: A Translational Success Story of Network Pharmacology. Clinical Pharmacology & Therapeutics vol. 99, (4) 360-362.
10.1002/cpt.3362015
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Moyes AJ, Chu SM, Baliga RS and
Hobbs AJ (2015).
Abstract 19478: Endothelial and Cardiomyocyte -derived C-type Natriuretic Peptide Coordinate Heart Structure and Function. Wolters Kluwer Circulation vol. 132, (suppl_3)
10.1161/circ.132.suppl_3.19478![](/publications/bullet24.png)
Sand CA and
Hobbs AJ (2015).
The nuances of NO synthase regulation in sepsis: Could targeting BH4 be the answer? Elsevier Vascular Pharmacology vol. 77, 35-37.
10.1016/j.vph.2015.10.008![](/publications/bullet24.png)
Allen RMH, Renukanthan A, Bubb KJ, Villar IC, Moyes AJ, Baliga RS and
Hobbs AJ (2015).
Investigation of the role of multidrug resistance proteins (MRPs) in vascular homeostasis. Springer Nature Bmc Pharmacology and Toxicology vol. 16, (Suppl 1)
10.1186/2050-6511-16-s1-a33
Hobbs AJ (2015).
Pivotal vascular homeostatic role for endothelium-derived C-type natriuretic peptide (CNP). Springer Nature Bmc Pharmacology and Toxicology vol. 16, (Suppl 1)
10.1186/2050-6511-16-s1-a27![](/publications/bullet24.png)
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A,
Xiao Q,
Hobbs A, Ye S and Caulfield M (2015).
Abstract P048: Blood-Pressure Associated Variants in Natriuretic Peptide Receptor C Affect Human Vascular Smooth Muscle Cells Proliferation and Calcium Flux in Response to Angiotensin II. Wolters Kluwer Hypertension vol. 66, (suppl_1)
10.1161/hyp.66.suppl_1.p048![](/publications/fav.png)
Peake NJ, Bader DL, Vessillier S, Ramachandran M, Salter DM,
Hobbs AJ and
Chowdhury TT (2015).
C-type natriuretic peptide signalling drives homeostatic effects in human chondrocytes. Elsevier Biochemical and Biophysical Research Communications vol. 465, (4) 784-789.
10.1016/j.bbrc.2015.08.087![](/publications/bullet24.png)
O'Brien A, China L, Massey KA, Nicolaou A, Winstanley A, Newson J,
Hobbs A, Audzevich T and Gilroy DW (2015).
Bile duct‐ligated mice exhibit multiple phenotypic similarities to acute decompensation patients despite histological differences. Wiley Liver International vol. 36, (6) 837-846.
10.1111/liv.12876![](/publications/bullet24.png)
Allen R, Renukanthan A, Bubb K, Villar I, Moyes A, Baliga R and
Hobbs A (2015).
Investigation of the Role of Multidrug Resistance Proteins (MRPs) in Vascular Homeostasis. Wiley The Faseb Journal vol. 29, (S1)
10.1096/fasebj.29.1_supplement.783.8![](/publications/fav.png)
Peake N, Pavlov A, D'Souza A, Alfasahin I, Pingaan-Murphy B, Sukhurukov G,
Hobbs A and
Chowdhury T (2015).
Polyelectrolyte microencapsules loaded with C-type natriuretic peptide protect cartilage from IL-1B induced damage. Elsevier Osteoarthritis and Cartilage vol. 23, a141-a142.
10.1016/j.joca.2015.02.881![](/publications/bullet24.png)
Papapetropoulos A,
Hobbs AJ and Topouzis S (2015).
Translational promise for NO pathway. Wiley British Journal of Pharmacology vol. 172, (6) 1397-1414.
10.1111/bph.12980![](/publications/fav.png)
Peake NJ, Pavlov AM, D'Souza A, Pingguan-Murphy B, Sukhorukov GB,
Hobbs AJ and
CHOWDHURY TT (2015).
Controlled Release of C-Type Natriuretic Peptide by Microencapsulation Dampens Proinflammatory Effects Induced by IL-1β in Cartilage Explants. American Chemical Society Biomacromolecules 10.1021/bm501575w![](/publications/bullet24.png)
Bubb KJ,
Hobbs AJ and Klinger JR (2015).
Modulation of cGMP Synthesis and Metabolism. Diagnosis and Management of Pulmonary Hypertension Springer Nature 10.1007/978-1-4939-2636-7_15![](/publications/bullet24.png)
Ren M, Ng FL, Witkowska K, Baron M, Townsend-Nicholson A,
Xiao Q,
Hobbs A, Ye S and Caulfield M (2015).
Blood-pressure associated variants in NPR3 affect human vascular smooth muscle cells proliferation and calcium response to angiotensin II. Journal of Human Hypertension vol. 29, (10) 624-624.
2014
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Ono K, Akaike T, Sawa T, Kumagai Y, Wink DA, Tantillo DJ,
Hobbs AJ, Nagy P, Xian M, Lin J and Fukuto JM (2014).
Redox chemistry and chemical biology of H2S, hydropersulfides, and derived species: implications of their possible biological activity and utility. Free Radic Biol Med vol. 77, 82-94.
10.1016/j.freeradbiomed.2014.09.007![](/publications/fav.png)
Peake NJ,
Hobbs AJ, Pingguan-Murphy B, Salter DM, Berenbaum F and
Chowdhury TT (2014).
Role of C-type natriuretic peptide signalling in maintaining cartilage and bone function. Osteoarthritis Cartilage vol. 22, (11) 1800-1807.
10.1016/j.joca.2014.07.018![](/publications/bullet24.png)
Moyes AJ, Khambata RS, Villar I, Bubb KJ, Baliga RS, Lumsden NG, Xiao F, Gane PJ, Rebstock A-S, Worthington RJ, Simone MI, Mota F, Rivilla F, Vallejo S, Peiró C, Sánchez Ferrer CF, Djordjevic S, Caulfield MJ, MacAllister RJ, Selwood DL,
Ahluwalia A and
Hobbs AJ (2014).
Endothelial C-type natriuretic peptide maintains vascular homeostasis. J Clin Invest vol. 124, (9) 4039-4051.
10.1172/JCI74281![](/publications/bullet24.png)
Bubb KJ, Trinder SL, Baliga RS, Patel J, Clapp LH, MacAllister RJ and
Hobbs AJ (2014).
Inhibition of phosphodiesterase 2 augments cGMP and cAMP signaling to ameliorate pulmonary hypertension. Circulation vol. 130, (6) 496-507.
10.1161/CIRCULATIONAHA.114.009751![](/publications/bullet24.png)
Baliga RS, Scotton CJ, Trinder SL, Chambers RC, MacAllister RJ and
Hobbs AJ (2014).
Intrinsic defence capacity and therapeutic potential of natriuretic peptides in pulmonary hypertension associated with lung fibrosis. Br J Pharmacol vol. 171, (14) 3463-3475.
10.1111/bph.12694
Hobbs AJ (2014).
Natriuretic peptide receptors and heart failure: to B or not to B blocked? Naunyn Schmiedebergs Arch Pharmacol vol. 387, (1) 1-4.
10.1007/s00210-013-0946-0![](/publications/bullet24.png)
Gonzales MA, Han H, Moyes A, Radinos A,
Hobbs AJ, Coombs N, Oliver SRJ and Mascharak PK (2014).
Light-triggered carbon monoxide delivery with Al-MCM-41-based nanoparticles bearing a designed manganese carbonyl complex. Journal of Materials Chemistry B vol. 2, (15) 2107-2113.
10.1039/c3tb21309a2013
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Alexander SPH, Benson HE, Faccenda E, Pawson AJ, Sharman JL, McGrath JC, Catterall WA, Spedding M, Peters JA, Harmar AJ, Abul-Hasn N, Anderson CM, Anderson CMH, Araiksinen MS, Arita M, Arthofer E, Barker EL, Barratt C, Barnes NM, Bathgate R, Beart PM, Belelli D, Bennett AJ, Birdsall NJM, Boison D, Bonner TI, Brailsford L, Bröer S, Brown P and Calo G (2013).
Overview. Wiley British Journal of Pharmacology vol. 170, (8) 1449-1458.
10.1111/bph.12444![](/publications/bullet24.png)
Derrett-Smith EC, Dooley A, Gilbane AJ, Trinder SL, Khan K, Baliga R, Holmes AM,
Hobbs AJ, Abraham D and Denton CP (2013).
Endothelial injury in a transforming growth factor β-dependent mouse model of scleroderma induces pulmonary arterial hypertension. Arthritis Rheum vol. 65, (11) 2928-2939.
10.1002/art.38078![](/publications/bullet24.png)
Ghosh SM, Kapil V, Fuentes-Calvo I, Bubb KJ, Pearl V, Milsom AB, Khambata R, Maleki-Toyserkani S, Yousuf M, Benjamin N, Webb AJ, Caulfield MJ,
Hobbs AJ and
Ahluwalia A (2013).
Enhanced vasodilator activity of nitrite in hypertension: critical role for erythrocytic xanthine oxidoreductase and translational potential. Hypertension vol. 61, (5) 1091-1102.
10.1161/HYPERTENSIONAHA.111.00933![](/publications/bullet24.png)
Baliga RS, Macallister RJ and
Hobbs AJ (2013).
Vasoactive peptides and the pathogenesis of pulmonary hypertension: role and potential therapeutic application. Handb Exp Pharmacol vol. 218, 477-511.
10.1007/978-3-642-38664-0_19![](/publications/bullet24.png)
Sciarretta S, Marchitti S, Bianchi F, Moyes A, Barbato E, Di Castro S, Stanzione R, Cotugno M, Castello L, Calvieri C, Eberini I, Sadoshima J,
Hobbs AJ, Volpe M and Rubattu S (2013).
C2238 Atrial Natriuretic Peptide Molecular Variant Is Associated With Endothelial Damage and Dysfunction Through Natriuretic Peptide Receptor C Signaling. Circulation Research vol. 112, (10) 1355-+.
10.1161/CIRCRESAHA.113.301325![](/publications/fav.png)
Peake N, Su N, Ramachandran M, Achan P, Salter DM, Bader DL, Moyes AJ,
Hobbs AJ and
Chowdhury TT (2013).
Natriuretic peptide receptors regulate cytoprotective effects in an ex vivo human 3D / bioreactor model. Bio Med Central Arthritis Research and Therapy vol. 15, (4)
10.1186/ar4253![](/publications/bullet24.png)
Baliga RS, MacAllister RJ and
Hobbs AJ (2013).
Vasoactive Peptides and the Pathogenesis of Pulmonary Hypertension: Role and Potential Therapeutic Application. Pharmacotherapy of Pulmonary Hypertension Springer Nature 10.1007/978-3-662-45805-1_192012
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Baliga RS, Milsom AB, Ghosh SM, Trinder SL, Macallister RJ,
Ahluwalia A and
Hobbs AJ (2012).
Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase. Circulation vol. 125, (23) 2922-2932.
10.1161/CIRCULATIONAHA.112.100586![](/publications/bullet24.png)
Gonzalez MA, Yim MA, Cheng S, Moyes A,
Hobbs AJ and Mascharak PK (2012).
Manganese Carbonyls Bearing Tripodal Polypyridine Ligands as Photoactive Carbon Monoxide-Releasing Molecules. Inorganic Chemistry vol. 51, (1) 601-608.
10.1021/ic2021287![](/publications/bullet24.png)
Moyes AJ, Khambata RS,
Ahluwalia A and
Hobbs AJ (2012).
Accelerated Atherogenesis and Diminished Vascular Integrity in Mice Lacking Endothelial C-Type Natriuretic Peptide. Circulation vol. 126, (21)
2011
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Khambata RS, Panayiotou CM and
Hobbs AJ (2011).
Natriuretic peptide receptor-3 underpins the disparate regulation of endothelial and vascular smooth muscle cell proliferation by C-type natriuretic peptide. Br J Pharmacol vol. 164, (2b) 584-597.
10.1111/j.1476-5381.2011.01400.x![](/publications/bullet24.png)
Pourcet B, Feig JE, Vengrenyuk Y,
Hobbs AJ, Kepka-Lenhart D, Garabedian MJ, Morris SM, Fisher EA and Pineda-Torra I (2011).
LXRα regulates macrophage arginase 1 through PU.1 and interferon regulatory factor 8. Circ Res vol. 109, (5) 492-501.
10.1161/CIRCRESAHA.111.241810![](/publications/bullet24.png)
Baliga RS, Trinder SL, Scotton CJ, Chambers RC, MacAllister RJ and
Hobbs AJ (2011).
Enhancing natriuretic peptide bioactivity prevents bleomycin-induced pulmonary fibrosis. Springer Nature Bmc Pharmacology vol. 11, (Suppl 1)
10.1186/1471-2210-11-s1-p3![](/publications/bullet24.png)
Quinteiro FM, Gane P, Rebstock A-S, Worthington R, Simone M, Djordevic S,
Hobbs A and Selwood D (2011).
Design and development of novel non-peptide agonists at NPR-C. Springer Nature Bmc Pharmacology vol. 11, (Suppl 1)
10.1186/1471-2210-11-s1-p54![](/publications/bullet24.png)
Villar IC, Scotland RS, Khambata RS, Chan M, Duchene J, Sampaio AL,
Perretti M,
Hobbs AJ and
Ahluwalia A (2011).
Suppression of endothelial P-selectin expression contributes to reduced cell trafficking in females: an effect independent of NO and prostacyclin. Arterioscler Thromb Vasc Biol vol. 31, (5) 1075-1083.
10.1161/ATVBAHA.111.223545![](/publications/bullet24.png)
Gonzalez MA, Fry NL, Burt R, Davda R,
Hobbs A and Mascharak PK (2011).
Designed Iron Carbonyls as Carbon Monoxide (CO) Releasing Molecules: Rapid CO Release and Delivery to Myoglobin in Aqueous Buffer, and Vasorelaxation of Mouse Aorta. Inorg Chem vol. 50, (7) 3127-3134.
10.1021/ic20008482010
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Derrett-Smith EC, Dooley A, Baliga R,
Hobbs A, MacAllister R, Abraham D and Denton CP (2010).
Perturbed VEGF signalling within the pulmonary vasculature of a TGF beta dependent mouse model of systemic sclerosis. Clin Exp Rheumatol vol. 28, (5) S63-S63.
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Madhani M, Hall AR, Cuello F, Charles RL, Burgoyne JR, Fuller W,
Hobbs AJ, Shattock MJ and Eaton P (2010).
Phospholemman Ser69 phosphorylation contributes to sildenafil-induced cardioprotection against reperfusion injury. Am J Physiol-Heart C vol. 299, (3) H827-H836.
10.1152/ajpheart.00129.2010![](/publications/bullet24.png)
Panayiotou CM, Baliga R, Stidwill R, Taylor V, Singer M and
Hobbs AJ (2010).
Resistance to endotoxic shock in mice lacking natriuretic peptide receptor-A. Br J Pharmacol vol. 160, (8) 2045-2054.
10.1111/j.1476-5381.2010.00830.x![](/publications/bullet24.png)
Kapil V, Milsom AB, Okorie M, Maleki-Toyserkani S, Akram F, Rehman F, Arghandawi S, Pearl V, Benjamin N, Loukogeorgakis S, Macallister R,
Hobbs AJ, Webb AJ and
Ahluwalia A (2010).
Inorganic nitrate supplementation lowers blood pressure in humans: role for nitrite-derived NO. Hypertension vol. 56, (2) 274-281.
10.1161/HYPERTENSIONAHA.110.153536![](/publications/bullet24.png)
Milsom AB, Patel NSA, Mazzon E, Tripatara P, Storey A, Mota-Filipe H, Sepodes B, Webb AJ, Cuzzocrea S,
Hobbs AJ, Thiemermann C and
Ahluwalia A (2010).
Role for endothelial nitric oxide synthase in nitrite-induced protection against renal ischemia-reperfusion injury in mice. Nitric Oxide-Biol Ch vol. 22, (2) 141-148.
10.1016/j.niox.2009.10.010![](/publications/bullet24.png)
Lumsden NG, Khambata RS and
Hobbs AJ (2010).
C-type Natriuretic Peptide (CNP): Cardiovascular Roles and Potential as a Therapeutic Target. Curr Pharm Design vol. 16, (37) 4080-4088.
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Khambata RS, Panayiotou CM, Xiao F and
Hobbs AJ (2010).
The anti-atherogenic potential of C-type natriuretic peptide: Disparate regulation of endothelial and vascular smooth muscle cell proliferation via natriuretic peptide receptor-C. Faseb Journal vol. 24,
10.1096/fasebj.24.1_supplement.573.4![](/publications/bullet24.png)
Lumsden NG, Khambata RS and
Hobbs AJ (2010).
C-type natriuretic peptide (CNP): cardiovascular roles and potential as a therapeutic target. Curr Pharm Des vol. 16, (37) 4080-4088.
10.2174/1381612107945192372009
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Duchene J, Cayla C, Vessillier S, Scotland R, Yamashiro K, Lecomte F, Syed I, Vo P, Marrelli A, Pitzalis C, Cipollone F, Schanstra J, Bascands J-L,
Hobbs AJ,
Perretti M and
Ahluwalia A (2009).
Laminar shear stress regulates endothelial kinin B1 receptor expression and function: potential implication in atherogenesis. Arterioscler Thromb Vasc Biol vol. 29, (11) 1757-1763.
10.1161/ATVBAHA.109.191775![](/publications/bullet24.png)
Miller TW, Cherney MM, Lee AJ, Francoleon NE, Farmer PJ, King SB,
Hobbs AJ, Miranda KM, Burstyn JN and Fukuto JM (2009).
The Effects of Nitroxyl (HNO) on Soluble Guanylate Cyclase Activity INTERACTIONS AT FERROUS HEME AND CYSTEINE THIOLS. J Biol Chem vol. 284, (33) 21788-21796.
10.1074/jbc.M109.014282![](/publications/bullet24.png)
Morris T, Stables M,
Hobbs A, de Souza P, Colville-Nash P, Warner T, Newson J, Bellingan G and Gilroy DW (2009).
Effects of Low-Dose Aspirin on Acute Inflammatory Responses in Humans. J Immunol vol. 183, (3) 2089-2096.
10.4049/jimmunol.0900477![](/publications/bullet24.png)
Kapil V, Rehman F, Arghandawi S, Milsom A, Benjamin N,
Hobbs A, MacAllister R, Webb A and
Ahluwalia A (2009).
BLOOD PRESSURE LOWERING EFFECTS OF ORAL INORGANIC NITRATE VIA BIOCONVERSION TO NITRITE. Basic Clin Pharmacol vol. 105, 31-31.
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Baliga RS, Trinder S, Scotton CJ, Chambers RC, MacAllister RJ and
Hobbs AJ (2009).
Manipulating the natriuretic peptide system for the treatment of pulmonary hypertension. Springer Nature Bmc Pharmacology vol. 9, (Suppl 1)
10.1186/1471-2210-9-s1-p2![](/publications/bullet24.png)
Okorie M, Akram F, Loukogeorgakis S, Webb A, Deanfield J, Benjamin N,
Hobbs A, MacAllister R and
Ahluwalia A (2009).
ORAL INORGANIC NITRATE PROTECTS AGAINST ENDOTHELIAL ISCHAEMIA-REPERFUSION INJURY IN HUMANS. Basic Clin Pharmacol vol. 105, 26-26.
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Diller GP, Bedard E, Wort SJ, Gatzoulis MA, van Eijl S, Ali O, Wilkins MR, Wharton J, Okonko DO, Howard LS, Thum T, Bauersachs J, Gibbs JSR and
Hobbs AJ (2009).
Response to Letter Regarding Article, Circulating Endothelial Progenitor Cells in Patients With Eisenmenger Syndrome and Idiopathic Pulmonary Arterial Hypertension. Circulation vol. 119, (9) E231-E231.
10.1161/CIRCULATIONAHA.108.816363![](/publications/bullet24.png)
Hajihosseini MK, Ramasamy S, De Langhe S, Lana-Elola E, Rice D, Rio LQ, Kelly R, Sharpe J and Bellusci S (2009).
Involvement of Fibroblast growth factor 10 (Fgf10) in the anterior-posterior patterning and specification of muscle and tendon progenitors in the developing mouse limbs. Faseb Journal vol. 23,
Hobbs AJ, Gane P, Lumsden N, Nobles M, Rebstock A-S, Simone M, Villar I, Worthington R, Xiao F,
Ahluwalia A and Selwood D (2009).
Design and development of novel non-peptide agonists at natriuretic peptide receptor-C. Faseb Journal vol. 23,
10.1096/fasebj.23.1_supplement.756.8![](/publications/bullet24.png)
Stasch J-P and
Hobbs AJ (2009).
NO-Independent, Haem-Dependent Soluble Guanylate Cyclase Stimulators. Cgmp: Generators, Effectors and Therapeutic Implications Springer Nature 10.1007/978-3-540-68964-5_132008
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Webb AJ, Milsom AB, Rathod KS, Chu WL, Qureshi S, Lovell MJ, Lecomte FMJ, Perrett D, Raimondo C, Khoshbin E, Ahmed Z, Uppal R, Benjamin N,
Hobbs AJ and
Ahluwalia A (2008).
Mechanisms underlying erythrocyte and endothelial nitrite reduction to nitric oxide in hypoxia: role for xanthine oxidoreductase and endothelial nitric oxide synthase. Circ Res vol. 103, (9) 957-964.
10.1161/CIRCRESAHA.108.175810![](/publications/bullet24.png)
Baliga RS, Zhao L, Madhani M, Lopez-Torondel B, Visintin C, Selwood D, Wilkins MR, MacAllister RJ and
Hobbs AJ (2008).
Synergy between natriuretic peptides and phosphodiesterase 5 inhibitors ameliorates pulmonary arterial hypertension. Am J Respir Crit Care Med vol. 178, (8) 861-869.
10.1164/rccm.200801-121OC![](/publications/bullet24.png)
Marro ML, Peiro C, Panayiotou CM, Baliga RS, Meurer S, Schmidt HHHW and
Hobbs AJ (2008).
Characterization of the human alpha(1)beta(1) soluble guanylyl cyclase promoter - Key role for NF-kappa B(p50) and CCAAT-binding factors in regulating expression of the nitric oxide receptor. J Biol Chem vol. 283, (29) 20027-20036.
10.1074/jbc.M801223200![](/publications/bullet24.png)
Diller GP, van Eijl S, Okonko DO, Howard LS, Ali O, Thum T, Wort SJ, Bedard E, Gibbs JSR, Bauersachs J,
Hobbs AJ, Wilkins MR, Gatzoulis MA and Wharton J (2008).
Circulating endothelial progenitor cells in patients with Eisenmenger syndrome and idiopathic pulmonary arterial hypertension. Circulation vol. 117, (23) 3020-3030.
10.1161/CIRCULATIONAHA.108.769646![](/publications/bullet24.png)
Villar IC,
Hobbs AJ and
Ahluwalia A (2008).
Sex differences in vascular function: implication of endothelium-derived hyperpolarizing factor. J Endocrinol vol. 197, (3) 447-462.
10.1677/JOE-08-0070![](/publications/bullet24.png)
Morton J, Coles B, Wright K, Gallimore A, Morrow JD, Terry ES, Anning PB, Morgan BP, Dioszeghy V, Kuhn H, Chaitidis P,
Hobbs AJ, Jones SA and O'Donnell VB (2008).
Circulating neutrophils maintain physiological blood pressure by suppressing bacteria and IFN gamma-dependent iNOS expression in the vasculature of healthy mice. Blood vol. 111, (10) 5187-5194.
10.1182/blood-2007-10-117283![](/publications/bullet24.png)
Webb AJ, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin N, MacAllister R,
Hobbs AJ and
Ahluwalia A (2008).
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension vol. 51, (3) 784-790.
10.1161/HYPERTENSIONAHA.107.103523![](/publications/bullet24.png)
Webb A, Patel N, Loukogeorgakis S, Okorie M, Aboud Z, Misra S, Rashid R, Miall P, Deanfield J, Benjamin B, Macallister R,
Hobbs A and Abluwalia A (2008).
Acute blood pressure lowering and vasoprotective effects of dietary nitrate. Faseb Journal vol. 22,
10.1096/fasebj.22.1_supplement.737.302007
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Panayiotou CM and
Hobbs AJ (2007).
NPR-A gene deletion reverses vascular dysfunction associated with sepsis. Springer Nature Bmc Pharmacology vol. 7, (Suppl 1)
10.1186/1471-2210-7-s1-p44
Hobbs AJ (2007).
Exploiting the natriuretic peptide system for the treatment of pulmonary hypertension. Springer Nature Bmc Pharmacology vol. 7, (Suppl 1)
10.1186/1471-2210-7-s1-s7![](/publications/bullet24.png)
Baliga RS, Zhao L, Wilkins MR, MacAllister RJ and
Hobbs AJ (2007).
Selective modulation of ANP-dependent dilatation in the pulmonary vasculature by PDE 5 inhibitors: a novel combination therapy for pulmonary hypertension? Springer Nature Bmc Pharmacology vol. 7, (Suppl 1)
10.1186/1471-2210-7-s1-p2![](/publications/bullet24.png)
Villar IC, Panayiotou CM, Sheraz A, Madhani M, Scotland RS, Nobles M, Kemp-Harper B,
Ahluwalia A and
Hobbs AJ (2007).
Definitive role for natriuretic peptide receptor-C in mediating the vasorelaxant activity of C-type natriuretic peptide and endothelium-derived hyperpolarising factor. Cardiovasc Res vol. 74, (3) 515-525.
10.1016/j.cardiores.2007.02.032![](/publications/bullet24.png)
Paolocci N, Jackson MI, Lopez BE, Miranda K, Tocchetti CG, Wink DA,
Hobbs AJ and Fukuto JM (2007).
The pharmacology of nitroxyl (HNO) and its therapeutic potential: Not just the janus face of NO. Pharmacology & Therapeutics vol. 113, (2) 442-458.
10.1016/j.pharmthera.2006.11.0022006
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Madhani M, Patra AK, Miller TW, Eroy-Reveles AA,
Hobbs AJ, Fukuto JM and Mascharak PK (2006).
Biological activity of designed photolabile metal nitrosyls: light-dependent activation of soluble guanylate cyclase and vasorelaxant properties in rat aorta. J Med Chem vol. 49, (25) 7325-7330.
10.1021/jm0604629![](/publications/bullet24.png)
Madhani M, Okorie M,
Hobbs AJ and MacAllister RJ (2006).
Reciprocal regulation of human soluble and particulate guanylate cyclases in vivo. Br J Pharmacol vol. 149, (6) 797-801.
10.1038/sj.bjp.0706920![](/publications/bullet24.png)
Villar IC,
Ahluwalia A and
Hobbs AJ (2006).
Distinct pathways regulate endothelium derived hyperpolarising factor-mediated responses in rat mesenteric arteries. Acta Pharmacol Sin vol. 27, (9) 1276-1276.
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Marro M, Panayiotou C and
Hobbs A (2006).
Vascular inflammation modulates alpha 1 and beta 1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells (HASMCs). Acta Pharmacol Sin vol. 27, 172-172.
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Panayiotou CM and
Hobbs AJ (2006).
C-Type natriuretic peptide mediates ERK1/2 phosphorylation via Gi-coupled natriuretic peptide receptor-C in rat aortic smooth muscle cells. Acta Pharmacol Sin vol. 27, 170-170.
2005
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Scotland RS, Cohen M, Foster P, Lovell M, Mathur A,
Ahluwalia A and
Hobbs AJ (2005).
C-type natriuretic peptide inhibits leukocyte recruitment and platelet-leukocyte interactions via suppression of P-selectin expression. P Natl Acad Sci Usa vol. 102, (40) 14452-14457.
10.1073/pnas.0504961102![](/publications/bullet24.png)
Marro ML and
Hobbs AJ (2005).
Characterisation of human a1 and b1 soluble guanylate cyclase promoter activity in human aortic smooth muscle cells. Springer Nature Bmc Pharmacology vol. 5, (Suppl 1)
10.1186/1471-2210-5-s1-p34![](/publications/bullet24.png)
Connelly L, Madhani M and
Hobbs AJ (2005).
Resistance to endotoxic shock in endothelial nitric-oxide synthase (eNOS) knock-out mice: a pro-inflammatory role for eNOS-derived no in vivo. J Biol Chem vol. 280, (11) 10040-10046.
10.1074/jbc.M411991200![](/publications/bullet24.png)
Scotland RS, Madhani M, Chauhan S, Moncada S, Andresen J, Nilsson H,
Hobbs AJ and
Ahluwalia A (2005).
Investigation of vascular responses in endothelial nitric oxide synthase/cyclooxygenase-1 double-knockout mice - Key role for endothelium-derived hyperpolarizing factor in the regulation of blood pressure in vivo. Circulation vol. 111, (6) 796-803.
10.1161/01.CIR.0000155238.70797.4E2004
Hobbs A, Foster P, Prescott C, Scotland R and
Ahluwalia A (2004).
Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury - Novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation vol. 110, (10) 1231-1235.
10.1161/01.CIR.0000141802.29945.34
Ahluwalia A, Foster P, Scotland RS, McLean PG, Mathur A,
Perretti M, Moncada S and
Hobbs AJ (2004).
Antiinflammatory activity of soluble guanylate cyclase: cGMP-dependent down-regulation of P-selectin expression and leukocyte recruitment. P Natl Acad Sci Usa vol. 101, (5) 1386-1391.
10.1073/pnas.0304264101
AHLUWALIA A,
Hobbs A, Prescott C, Scotland R and Foster P (2004).
Natriuretic peptide receptor-C regulates coronary blood flow and prevents myocardial ischemia/reperfusion injury: novel cardioprotective role for endothelium-derived C-type natriuretic peptide. Circulation vol. 110, (10) 1231-1235.
10.1161/01.CIR.0000141802.29945.342003
Hobbs AJ and Moncada S (2003).
Antiplatelet properties of a novel, non-NO-based soluble guanylate cyclase activator, BAY 41-2272. Vascul Pharmacol vol. 40, (3) 149-154.
10.1016/s1537-1891(03)00046-6![](/publications/bullet24.png)
Madhani M, Scotland RS, MacAllister RJ and
Hobbs AJ (2003).
Vascular natriuretic peptide receptor-linked particulate guanylate cyclases are modulated by nitric oxide-cyclic GMP signalling. Br J Pharmacol vol. 139, (7) 1289-1296.
10.1038/sj.bjp.0705365![](/publications/bullet24.png)
Connelly L, Jacobs AT, Palacios-Callender M, Moncada S and
Hobbs AJ (2003).
Macrophage endothelial nitric-oxide synthase autoregulates cellular activation and pro-inflammatory protein expression. J Biol Chem vol. 278, (29) 26480-26487.
10.1074/jbc.M302238200![](/publications/bullet24.png)
Madhani M, MacAllister R and
Hobbs A (2003).
Interactions between soluble guanylate cyclase and natriuretic peptide receptor-linked particulate guanylate cyclases in the mammalian vasculature. Springer Nature Bmc News and Views vol. 3, (S2)
10.1186/2048-4623-3-s2-p0033![](/publications/bullet24.png)
Chauhan SD, Nilsson H,
Ahluwalia A and
Hobbs AJ (2003).
Release of C-type natriuretic peptide accounts for the biological activity of endothelium-derived hyperpolarizing factor. P Natl Acad Sci Usa vol. 100, (3) 1426-1431.
10.1073/pnas.0336365100![](/publications/bullet24.png)
Kalsi JS, Rees RW,
Hobbs AJ, Royle M, Kell PD, Ralph DJ, Moncada S and Cellek S (2003).
BAY41-2272, a novel nitric oxide independent soluble guanylate cyclase activator, relaxes human and rabbit corpus cavernosum in vitro. J Urol vol. 169, (2) 761-766.
10.1097/01.ju.0000043880.58140.69![](/publications/bullet24.png)
KALSI JS, REES RW,
HOBBS AJ, ROYLE M, KELL PD, RALPH DJ, MONCADA S and CELLEK S (2003).
BAY41-2272, a Novel Nitric Oxide Independent Soluble Guanylate Cyclase Activator, Relaxes Human and Rabbit Corpus Cavernosum In Vitro. Wolters Kluwer Journal of Urology vol. 169, (2) 761-766.
10.1097/00005392-200302000-00081
AHLUWALIA A,
Hobbs AJ, Seggara G, Chauhan SD, Vo PA and MacAllister RJ (2003).
Protection against liposaccharide-induced endothelial dysfunction in resistance and conduit vasculature of iNOS knockout mice. Faseb J vol. 17, (6) 773-775.
10.1096/fj.02-0668fje2002
Hobbs AJ, Gladwin MT, Patel RP, Williams DLH and Butler AR (2002).
Haemoglobin: NO transporter, NO inactivator or NOne of the above? Trends Pharmacol Sci vol. 23, (9) 406-411.
10.1016/s0165-6147(02)02067-9
Hobbs AJ, Gladwin MT, Patel RP, Williams DLH and Butler AR (2002).
Haernoglobin: NO transporter, NO inactivator or NOne of the above? Trends Pharmacol Sci vol. 23, (9) 406-411.
10.1016/S0165-6147(02)02067-9![](/publications/bullet24.png)
Chauhan SD, MacAllister RJ,
Hobbs AJ and
Ahluwalia A (2002).
Mechanisms underlying the vasorelaxant activity of C-type natriuretic peptide (CNP) in rat mesenteric resistance arteries. Faseb J vol. 16, (4) A572-A572.
2001
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Connelly L, Palacios-Callender M, Ameixa C, Moncada S and
Hobbs AJ (2001).
Biphasic regulation of NF-kappa B activity underlies the pro- and anti-inflammatory actions of nitric oxide. J Immunol vol. 166, (6) 3873-3881.
10.4049/jimmunol.166.6.3873![](/publications/bullet24.png)
Hussain MB, MacAllister RJ and
Hobbs AJ (2001).
Reciprocal regulation of cGMP-mediated vasorelaxation by soluble and particulate guanylate cyclases. Am J Physiol Heart Circ Physiol vol. 280, (3) H1151-H1159.
10.1152/ajpheart.2001.280.3.H1151![](/publications/bullet24.png)
Selwood DL, Brummell DG, Budworth J, Burtin GE, Campbell RO, Chana SS, Charles IG, Fernandez PA, Glen RC, Goggin MC,
Hobbs AJ, Kling MR, Liu Q, Madge DJ, Meillerais S, Powell KL, Reynolds K, Spacey GD, Stables JN, Tatlock MA, Wheeler KA, Wishart G and Woo CK (2001).
Synthesis and biological evaluation of novel pyrazoles and indazoles as activators of the nitric oxide receptor, soluble guanylate cyclase. J Med Chem vol. 44, (1) 78-93.
10.1021/jm001034k2000
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Cavero M,
Hobbs A, Madge D, Motherwell WB, Selwood D and Potier P (2000).
Synthesis and biological evaluation of enantiopure thionitrites: the solid-phase synthesis and nitrosation of D-glutathione as a molecular probe. Bioorg Med Chem Lett vol. 10, (7) 641-644.
10.1016/s0960-894x(00)00060-3![](/publications/bullet24.png)
Hussain MB, MacAllister RJ and
Hobbs AJ (2000).
Regulation of cGMP-mediated vasorelaxation in mouse thoracic aorta: Interactions of the soluble and particulate guanylate cyclases. Brit J Pharmacol vol. 129,
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Shah S,
Hobbs A, Singh R, Cuevas J, Ignarro LJ and Chaudhuri G (2000).
Gastrointestinal motility during pregnancy: role of nitrergic component of NANC nerves. American Journal of Physiology-Regulatory Integrative and Comparative Physiology vol. 279, (4) R1478-R1485.
10.1152/ajpregu.2000.279.4.R14781999
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Hussain MB,
Hobbs AJ and MacAllister RJ (1999).
Autoregulation of nitric oxide-soluble guanylate cyclase-cyclic GMP signalling in mouse thoracic aorta. Br J Pharmacol vol. 128, (5) 1082-1088.
10.1038/sj.bjp.0702874![](/publications/bullet24.png)
Wolzt M, MacAllister RJ, Davis D, Feelisch M, Moncada S, Vallance P and
Hobbs AJ (1999).
Biochemical characterization of S-nitrosohemoglobin. Mechanisms underlying synthesis, no release, and biological activity. J Biol Chem vol. 274, (41) 28983-28990.
10.1074/jbc.274.41.28983
Hobbs AJ and Ignarro LJ (1999).
Chemistry and Molecular Biology of Nitric Oxide Synthesis. The Haemodynamic Effects of Nitric Oxide World Scientific Publishing 10.1142/9781848160781_0003![](/publications/bullet24.png)
Hussain MB,
Hobbs AJ and MacAllister RJ (1999).
Enhanced sensitivity of the soluble guanylate cyclase/cyclic GMP system in the eNOS knockout mouse. Brit J Pharmacol vol. 126, U41-U41.
1997
1996
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Cohen GA,
Hobbs AJ, Fitch RM, Zinner MJ, Chaudhuri G and Ignarro LJ (1996).
Nitric oxide regulates endothelium-dependent vasodilator responses in rabbit hindquarters vascular bed in vivo. Am J Physiol vol. 271, (1 Pt 2) H133-H139.
10.1152/ajpheart.1996.271.1.H1331995
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SHAH SN, CUEVAS JM,
HOBBS AJ, WHANG E, IGNARRO LJ, ASHLEY SW and CHAUDHURI G (1995).
ENHANCED ACTIONS OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE FUNCTION DURING PREGNANCY. Gastroenterology vol. 108, (4) A1246-A1246.
10.1016/0016-5085(95)29278-0![](/publications/bullet24.png)
Griscavage JM,
Hobbs AJ and Ignarro LJ (1995).
Negative modulation of nitric oxide synthase by nitric oxide and nitroso compounds. Adv Pharmacol vol. 34, 215-234.
10.1016/s1054-3589(08)61088-1![](/publications/bullet24.png)
SHAH SN, CUEVAS JM,
HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ and CHAUDHURI G (1995).
CHANGES IN GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY MAY BE INDUCED BY NITRIC-OXIDE. Gastroenterology vol. 108, (4) A688-A688.
10.1016/0016-5085(95)27063-9
HOBBS AJ, COHEN GA, FITCH RM, YIN TL, CHAUDHURI G and IGNARRO LJ (1995).
DIFFERENTIAL INHIBITORY EFFECT OF L-NAME ON ENDOTHELIUM-DEPENDENT RELAXATION IN-VITRO AND IN-VIVO. Faseb Journal vol. 9, (3) A328-A328.
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SHAH SN, CUEVAS JM,
HOBBS AJ, WHANG E, ASHLEY SW, IGNARRO LJ and CHAUDHURI G (1995).
THE ROLE OF NITRIC-OXIDE IN MODULATING GASTROINTESTINAL SMOOTH-MUSCLE REACTIVITY DURING PREGNANCY. Faseb Journal vol. 9, (3) A86-A86.
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COHEN GA,
HOBBS AJ, FITCH RM, ASHLEY SW, CRYER MH, CHAUDHURI G and IGNARRO LJ (1995).
STIMULATED RELEASE OF NITRIC-OXIDE (NO) IS LINKED TO ALPHA-ADRENOCEPTOR ACTIVATION IN-VIVO. Faseb Journal vol. 9, (3) A328-A328.
1994
HOBBS AJ, FUKUTO JM and IGNARRO LJ (1994).
FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE - DIRECT ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE. Proceedings of The National Academy of Sciences of The United States of America vol. 91, (23) 10992-10996.
10.1073/pnas.91.23.10992
HOBBS AJ, GRISCAVAGE JM, ROGERS NE, BYRNS RE, FUKUTO JM and IGNARRO LJ (1994).
FORMATION OF FREE NITRIC-OXIDE FROM L-ARGININE BY NITRIC-OXIDE SYNTHASE AND ENHANCEMENT OF GENERATION BY SUPEROXIDE-DISMUTASE. Faseb Journal vol. 8, (4) A360-A360.
1993
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Fukuto JM,
Hobbs AJ and Ignarro LJ (1993).
Conversion of nitroxyl (HNO) to nitric oxide (NO) in biological systems: the role of physiological oxidants and relevance to the biological activity of HNO. Biochem Biophys Res Commun vol. 196, (2) 707-713.
10.1006/bbrc.1993.2307![](/publications/bullet24.png)
Brave SR, Bhat S,
Hobbs AJ, Tucker JF and Gibson A (1993).
The influence of L-NG-nitro-arginine on sympathetic nerve induced contraction and noradrenaline release in the rat isolated anococcygeus muscle. J Auton Pharmacol vol. 13, (3) 219-225.
10.1111/j.1474-8673.1993.tb00269.x1992
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Gibson A, Babbedge R, Brave SR, Hart SL,
Hobbs AJ, Tucker JF, Wallace P and Moore PK (1992).
An investigation of some S-nitrosothiols, and of hydroxy-arginine, on the mouse anococcygeus. Br J Pharmacol vol. 107, (3) 715-721.
10.1111/j.1476-5381.1992.tb14512.x1991
Hobbs AJ, Tucker JF and Gibson A (1991).
Differentiation by hydroquinone of relaxations induced by exogenous and endogenous nitrates in non-vascular smooth muscle: role of superoxide anions. Br J Pharmacol vol. 104, (3) 645-650.
10.1111/j.1476-5381.1991.tb12483.x![](/publications/bullet24.png)
Brave SR,
Hobbs AJ, Gibson A and Tucker JF (1991).
The influence of L-NG-nitro-arginine on field stimulation induced contractions and acetylcholine release in guinea pig isolated tracheal smooth muscle. Biochem Biophys Res Commun vol. 179, (2) 1017-1022.
10.1016/0006-291x(91)91920-8![](/publications/bullet24.png)
Mirzazadeh S,
Hobbs AJ, Tucker JF and Gibson A (1991).
Cyclic nucleotide content of the rat anococcygeus during relaxations induced by drugs or by non-adrenergic, non-cholinergic field stimulation. J Pharm Pharmacol vol. 43, (4) 247-251.
10.1111/j.2042-7158.1991.tb06677.x1990
Hobbs AJ and Gibson A (1990).
L-NG-nitro-arginine and its methyl ester are potent inhibitors of non-adrenergic, non-cholinergic transmission in the rat anococcygeus. Br J Pharmacol vol. 100, (4) 749-752.
10.1111/j.1476-5381.1990.tb14086.x![](/publications/bullet24.png)
Tucker JF, Brave SR, Charalambous L,
Hobbs AJ and Gibson A (1990).
L-NG-nitro arginine inhibits non-adrenergic, non-cholinergic relaxations of guinea-pig isolated tracheal smooth muscle. Br J Pharmacol vol. 100, (4) 663-664.
10.1111/j.1476-5381.1990.tb14072.x![](/publications/bullet24.png)
Gibson A,
Hobbs AJ and Mirzazadeh S (1990).
L-NG-nitroarginine is a potent inhibitor of non-adrenergic, non-cholinergic relaxations in the rat anococcygeus muscle. Elsevier European Journal of Pharmacology vol. 183, (5)
10.1016/0014-2999(90)92110-5![](/publications/bullet24.png)
Gibson A, Mirzazadeh S,
Hobbs AJ and Moore PK (1990).
L-NG-monomethyl arginine and L-NG-nitro arginine inhibit non-adrenergic, non-cholinergic relaxation of the mouse anococcygeus muscle. Br J Pharmacol vol. 99, (3) 602-606.
10.1111/j.1476-5381.1990.tb12976.x