Dr Ana Caetano
Clinical Senior Lecturer
Institute of Dentistry
Queen Mary University of London
Queen Mary University of London
Research
peripheral nervous system, neuroimmune interactions, neuro-stem cell interactions, oral mucosa, computational modelling
Interests
Our lab studies the nervous system of the oral mucosa to understand how its development, organisation and function regulate health and disease mechanisms. We use a wide range of experimental techniques, including molecular and genetic manipulations, advanced microscopy, next-generation sequencing approaches, bioinformatics and computational modelling. We are now aiming to develop complex oral mucosa in vitro models to allow us to further investigate neuroimmune and neuro-epithelial interactions.Publications
Publications of specific relevance to Predictive <em>in vitro</em> Models2025
Transcriptome analysis of granulation tissue from periodontal osseous defectsSam YH, Caetano AJ, Owen DR, Mainas G, Nibali L and Ghuman M
The Journal of Periodontology
12-05-2025
2024
Computational Methods for Image Analysis in Craniofacial Development and DiseaseJames E, Caetano AJ and Sharpe PT
Journal of Dental Research, Sage Publications vol. 103 (13), 1340-1348.
13-09-2024
Redefining Mucosal Inflammation with Spatial GenomicsCaetano AJ and Sharpe PT
Journal of Dental Research, Sage Publications vol. 103 (2), 129-137.
03-01-2024
2023
Spatially resolved transcriptomics reveals pro-inflammatory fibroblast involved in lymphocyte recruitment through CXCL8 and CXCL10Caetano AJ, Redhead Y, Karim F, Dhami P, Kannambath S, Nuamah R, Volponi AA, Nibali L, Booth V, D'Agostino EM and Sharpe PT
Elife, Elife vol. 12
17-01-2023
2022
A Roadmap for the Human Oral and Craniofacial Cell AtlasCaetano AJ, Caetano A, Sharpe P, Volponi AA, Yianni V, Bush M, McKay LK, Wallet S, Shazib MA, Kimple A, Byrd KM, Easter Q, Weaver T, Sequeira I, Kumar R, Pereira D, Macken J, Fortune F, Efremova M, Teichmann S, Kretzschmar K, Todres E, Boffelli D, Hagood JS, Klein O, Boucher R, Lwin S, Pranzatelli T, Beachy P and Lu WJ
Journal of Dental Research, Sage Publications vol. 101 (11), 1274-1288.
26-09-2022
2021
Defining human mesenchymal and epithelial heterogeneity in response to oral inflammatory diseaseCaetano AJ, Yianni V, Volponi A, Booth V, D'Agostino EM and Sharpe P
Elife, Elife vol. 10
04-01-2021
Grants
Grants of specific relevance to Predictive in vitro ModelsThe influence of a complex in vitro tumour microenvironment on cancer stem cells metastasisAdrian Biddle and Ana Caetano
£547,066 National Centre for the Replacement, Refinement and Reduction of Animals in Research
01-05-2025 - 30-04-2028
Neuroimmune interactions in oral barrier functionAna Caetano
£127,935 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2024 - 30-09-2028
Neuroimmune interactions in oral barrier functionAna Caetano
£78,600 Unilever UK Ltd
01-10-2024 - 30-09-2028
The Role of Peripheral Neuroglia In Oral Spuamous Cell CancerAna Caetano and Adrian Biddle
£317,529 MCSBHT Medical College of St Bartholomew's Hospital Trust
01-10-2024 - 31-12-2027