Dr Weiqi Li
School of Engineering and Materials Science/Institute of Bioengi
Queen Mary University of London
Queen Mary University of London
Research
The endothelial glycocalyx, Actin cytoskeleton, Junctional complex, Cell mechanics, Directional cell migration, Angiogenesis
Interests
My research interest lies in the mechano-regulation of the endothelial glycocalyx in vitro, particularly looking into the interplay with the cytoskeletal system and junctional complex, with the use of super-resolution microscopy, confocal microscopy and atomic force microscopy.Publications
Publications of specific relevance to Predictive in vitro Models2021
Li W and Wang W (2021). The role of actomyosin in the regulation of syndecan-1 in hyperosmosis. Elsevier Bba - General Subjects vol. 1865, (10) 10.1016/j.bbagen.2021.129975Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS (2021). Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion. American Chemical Society Acs Applied Materials and Interfaces vol. 13, (22) 25792-25804. 10.1021/acsami.1c055742020
Wu Y, Wang W, Mata A, Pugno N, Azevedo H, Karabasov S and Titirici M-M (2020). Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices. Nature Research (Part of Springer Nature) Nature Communications 10.1038/s41467-020-14716-z2019
Li W and Wang W (2019). Membrane tension regulates syndecan-1 expression through actin remodelling. Biochim Biophys Acta Gen Subj vol. 1863, (11) 129413-129413. 10.1016/j.bbagen.2019.129413Pang X, Li W, Landwehr E, Yuan Y, Wang W and Azevedo HS (2019). Mimicking the endothelial glycocalyx through the supramolecular presentation of hyaluronan on patterned surfaces. Faraday Discuss 10.1039/c9fd00015a2018
Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM and Shelton JC (2018). Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages. European Cells and Materials vol. 36, 142-155. 10.22203/eCM.v036a112017
Li W and Wang W (2017). Structural alteration of the endothelial glycocalyx: contribution of the actin cytoskeleton. Biomech Model Mechanobiol 10.1007/s10237-017-0950-22015
Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M and Barber AH (2015). 3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration. Elsevier/Science Direct Acta Biomaterialia vol. 27, 88-100. 10.1016/j.actbio.2015.09.0032014
Lu$y.lu@derby.ac.uk$School of Engineering and Technology Y, University of Derby , Derby , Science UW-QLSOEAM, Mary , University of London , London , Oraifige$School of Engineering and Technology UI and Science UWWSOEAM (2014). Converging Parallel Plate Flow Chambers for Studies on the Effect of the Spatial Gradient of Wall Shear Stress on Endothelial Cells. Journal of Biosciences and Medicines vol. 02, (02) 50-56. 10.4236/jbm.2014.22008Grants
X-ray imaging:Learning from other disciplinesWithers P, Li W, Davis GR, Elliott J, Lee P, Lionheart WR, Mummery P and Reader AJ
£270,062 Engineering and Physical Sciences Research Council (30-09-2007 - 30-03-2009)