Dr Weiqi Li

Weiqi Li
School of Engineering and Materials Science/Institute of Bioengi
Queen Mary University of London


The endothelial glycocalyx, Actin cytoskeleton, Junctional complex, Cell mechanics, Directional cell migration, Angiogenesis


My research interest lies in the mechano-regulation of the endothelial glycocalyx in vitro, particularly looking into the interplay with the cytoskeletal system and junctional complex, with the use of super-resolution microscopy, confocal microscopy and atomic force microscopy.


Publications of specific relevance to Predictive in vitro Models


Li W and Wang W (2021). The role of actomyosin in the regulation of syndecan-1 in hyperosmosis. Elsevier  Bba - General Subjects  vol. 1865, (10) 10.1016/j.bbagen.2021.129975
Pang X, Li W, Chang L, Gautrot JE, Wang W and Azevedo HS (2021). Hyaluronan (HA) Immobilized on Surfaces via Self-Assembled Monolayers of HA-Binding Peptide Modulates Endothelial Cell Spreading and Migration through Focal Adhesion. American Chemical Society  Acs Applied Materials and Interfaces  vol. 13, (22) 25792-25804. 10.1021/acsami.1c05574


Wu Y, Wang W, Mata A, Pugno N, Azevedo H, Karabasov S and Titirici M-M (2020). Disordered protein-graphene oxide co-assembly and supramolecular biofabrication of functional fluidic devices. Nature Research (Part of Springer Nature)  Nature Communications  10.1038/s41467-020-14716-z


Li W and Wang W (2019). Membrane tension regulates syndecan-1 expression through actin remodelling. Biochim Biophys Acta Gen Subj  vol. 1863, (11) 129413-129413. 10.1016/j.bbagen.2019.129413
Pang X, Li W, Landwehr E, Yuan Y, Wang W and Azevedo HS (2019). Mimicking the endothelial glycocalyx through the supramolecular presentation of hyaluronan on patterned surfaces. Faraday Discuss  10.1039/c9fd00015a


Xu J, Nyga A, Li W, Zhang X, Gavara N, Knight MM and Shelton JC (2018). Cobalt ions stimulate a fibrotic response through matrix remodelling, fibroblast contraction and release of pro-fibrotic signals from macrophages. European Cells and Materials  vol. 36, 142-155. 10.22203/eCM.v036a11


Li W and Wang W (2017). Structural alteration of the endothelial glycocalyx: contribution of the actin cytoskeleton. Biomech Model Mechanobiol  10.1007/s10237-017-0950-2


Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M and Barber AH (2015). 3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration. Elsevier/Science Direct  Acta Biomaterialia  vol. 27, 88-100. 10.1016/j.actbio.2015.09.003


Lu$y.lu@derby.ac.uk$School of Engineering and Technology Y, University of Derby , Derby , Science UW-QLSOEAM, Mary , University of London , London , Oraifige$School of Engineering and Technology UI and Science UWWSOEAM (2014). Converging Parallel Plate Flow Chambers for Studies on the Effect of the Spatial Gradient of Wall Shear Stress on Endothelial Cells. Journal of Biosciences and Medicines  vol. 02, (02) 50-56. 10.4236/jbm.2014.22008


Grants of specific relevance to Predictive in vitro Models
X-ray imaging:Learning from other disciplines
Withers P, Li W, Davis GR, Elliott J, Lee P, Lionheart WR, Mummery P and Reader AJ
£270,062 Engineering and Physical Sciences Research Council (30-09-2007 - 30-03-2009)