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Dr Simon Rawlinson

Simon Rawlinson

Senior Lecturer

Dentistry
Queen Mary University of London
020 7882 7139

www.qmul.ac.uk/dentistry/people/profiles/drsimoncharlesfieldingrawlinson.html

Research

Bone, Mechanobiology, Strain, Shear

Interests

Interest in further developing models to best replicate forces engendered in bone by mechanical loading

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Rawlinson SCF (2020). Mechanobiology Journal —Welcome Editorial. 10.32371/mbj/236079

2019

Caetano-Silva SP, Novicky A, Javaheri B, Rawlinson SCF and Pitsillides AA (2019). Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation. 10.1007/978-1-4939-8997-3_6

2018

Gharibi B, Ghuman MS, Cama G, Rawlinson SCF, Grigoriadis AE and Hughes FJ (2018). Site-specific differences in osteoblast phenotype, mechanical loading response and estrogen receptor-related gene expression. Mol Cell Endocrinol  vol. 477, 140-147. 10.1016/j.mce.2018.06.011
Liu J, Zheng F, Rawlinson SCF, Fortune F and Kim DG (2018). Bone biology and bioactive glass in bone regeneration. Bone Regeneration: Concepts, Clinical Aspects and Future Directions 

2017

Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE and Pitsillides AA (2017). Corrigendum: Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. Cell Biochem Funct  vol. 35, (4) 244-244. 10.1002/cbf.3268
Huang M, Hill RG and Rawlinson SCF (2017). Zinc bioglasses regulate mineralization in human dental pulp stem cells. Elsevier  Dental Materials  vol. 33, (5) 543-552. 10.1016/j.dental.2017.03.011
Rawlinson S (2017). Mechanobiology Exploitation for Medical Benefit. John Wiley & Sons 
Rawlinson SCF (2017). Mechanical Responsiveness of Distinct Skeletal Elements. Mechanobiology  10.1002/9781118966174.ch8
RAWLINSON SCF (2017). Mechanical responsiveness of distinct skeletal elements – possible exploitation of low weight-bearing bone. Mechanobiology: Exploitation For Medical Benefit  Wiley Blackwell 
Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE and Pitsillides AA (2017). Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. Cell Biochem Funct  vol. 35, (1) 56-65. 10.1002/cbf.3245

2016

Liu J, Rawlinson S, Hill R and FORTUNE F (2016). Fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects. Elsevier  Dental Materials  vol. 32, (10) e221-e237. 10.1016/j.dental.2016.07.003
Huang M, Hill RG and Rawlinson SCF (2016). Strontium (Sr) elicits odontogenic differentiation of human dental pulp stem cells (hDPSCs): A therapeutic role for Sr in dentine repair? Elsevier  Acta Biomaterialia  10.1016/j.actbio.2016.04.037
Liu J, Rawlinson SCF, Hill RG and Fortune F (2016). Strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects. Dental Materials  vol. 32, (3) 412-422. 10.1016/j.dental.2015.12.013

2015

Stachewicz U, Qiao T, Rawlinson SCF, Veiga Almeida F, Li WQ, Cattell M and Barber AH (2015). Microscopy and supporting data for osteoblast integration within an electrospun fibrous network. Data in Brief  vol. 5, 775-781. 10.1016/j.dib.2015.10.009
Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M and Barber AH (2015). 3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration. Elsevier/Science Direct  Acta Biomaterialia  vol. 27, 88-100. 10.1016/j.actbio.2015.09.003
Memarzadeh K, Sharili AS, Huang J, Rawlinson SCF and Allaker RP (2015). Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants. Journal of Biomedical Materials Research - Part A  vol. 103, (3) 981-989. 10.1002/jbm.a.35241
Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li WQ, Cattell M and Barber AH (2015). 3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration. Acta Biomaterialia  vol. 27, 88-100. 10.1016/j.actbio.2015.09.003

2014

Memarzadeh K, Sharili AS, Huang J, Rawlinson SCF and Allaker RP (2014). Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants. Journal of Biomedical Materials Research - Part A  10.1002/jbm.a.35241

2013

Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Behaviour of osteoblast-like cells cultured on titanium coated with FA/glass composite coating. Journal of Non-Crystalline Solids  vol. 364, 85-91. 10.1016/j.jnoncrysol.2012.12.041
Kingsmill VJ, McKay IJ, Ryan P, Ogden MR and Rawlinson SCF (2013). Gene expression profiles of mandible reveal features of both calvarial and ulnar bones in the adult rat. J Dent  vol. 41, (3) 258-264. 10.1016/j.jdent.2012.11.010
Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA addition on bioactivity of bioactive glass coating for titanium dental implant: Part II— Composite coating. Journal of Non-Crystalline Solids  vol. 364, 99-106. 10.1016/j.jnoncrysol.2012.11.046
Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA on bioactivity of bioactive glass coating for titanium dental implant. Part I: Composite powder. Journal of Non-Crystalline Solids  vol. 364, 92-98. 10.1016/j.jnoncrysol.2012.11.051
Al-Noaman A, Rawlinson SCF and Hill RG (2013). Bioactive glass-stoichimetric wollastonite glass alloys to reduce TEC of bioactive glass coatings for dental implants. Materials Letters  vol. 94, 69-71. 10.1016/j.matlet.2012.12.017

2012

Al-Noaman A, Rawlinson SCF and Hill RG (2012). The role of MgO on thermal properties, structure and bioactivity of bioactive glass coating for dental implants. Journal of Non-Crystalline Solids  vol. 358, (22) 3019-3027. 10.1016/j.jnoncrysol.2012.07.039
Al-Noaman A, Rawlinson SCF and Hill RG (2012). The influence of CaF2 content on the physical properties and apatite formation of bioactive glass coatings for dental implants. Journal of Non-Crystalline Solids  vol. 358, (15) 1850-1858. 10.1016/j.jnoncrysol.2012.05.039
Pitsillides AA and Rawlinson SCF (2012). Using cell and organ culture models to analyze responses of bone cells to mechanical stimulation. Methods Mol Biol  vol. 816, 593-619. 10.1007/978-1-61779-415-5_37

2010

Kingsmill VJ, Boyde A, Davis GR, Howell PGT and Rawlinson SCF (2010). Changes in bone mineral and matrix in response to a soft diet. J Dent Res  vol. 89, (5) 510-514. 10.1177/0022034510362970

2009

Rawlinson SCF, Mckay IJ, Ghuman M, Wellmann C, Ryan P, Prajaneh S, Zaman G, Hughes FJ and Kingsmill VJ (2009). Adult Rat Bones Maintain Distinct Regionalized Expression of Markers Associated with Their Development. Plos One  vol. 4, (12) 10.1371/journal.pone.0008358
Rawlinson SCF, Murray DH, Mosley JR, Wright CDP, Bredl JC, Saxon LK, Loveridge N, Leterrier C, Constantin P, Farquharson C and Pitsillides AA (2009). Genetic selection for fast growth generates bone architecture characterised by enhanced periosteal expansion and limited consolidation of the cortices but a diminution in the early responses to mechanical loading. Bone  vol. 45, (2) 357-366. 10.1016/j.bone.2009.04.243
Rawlinson SCF, Boyde A, Davis GR, Howell PGT, Hughes FJ and Kingsmill VJ (2009). Ovariectomy vs. Hypofunction: Their Effects on Rat Mandibular Bone. J Dent Res  vol. 88, (7) 615-620. 10.1177/0022034509340132
Rawlinson SCF, McKay IJ, Ghuman M, Wellmann C, Hughes FJ and Kingsmill VJ (2009). POST-MENOPAUSAL OSTEOPOROSIS-RESISTANT SKULL BONES – GENOTYPICALLY DISTINCT FROM OSTEOPOROTIC-SUSCEPTIBLE LIMB BONE. Maturitas  vol. 63, 10.1016/s0378-5122(09)70152-5

2008

Simon DWN, Clarkin CE, Das-Gupta V, Rawlinson SCF, Emery RJ and Pitsillides AA (2008). Identifying the cellular basis for reimplantation failure in repair of the rotator cuff. J Bone Joint Surg Br  vol. 90B, (5) 680-684. 10.1302/0301-620X.90B5.20013

2005

De Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE and Pitsillides AA (2005). Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element. Bone  vol. 37, (6) 810-818. 10.1016/j.bone.2005.07.022

2004

Jessop HL, Suswillo RFL, Rawlinson SCF, Zaman G, Lee K, Das-Gupta V, Pitsillides AA and Lanyon LE (2004). Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. J Bone Miner Res  vol. 19, (6) 938-946. 10.1359/JBMR.

2003

Pitsillides AA, Das-Gupta V, Simon D and Rawlinson SCF (2003). Methods for Analyzing Bone Cell Responses to Mechanical Loading Using In Vitro Monolayer and Organ Culture Models. Bone Research Protocols  10.1385/1-59259-366-6:399
PITSILLIDES AA, DAS-GUPTA V, SIMON D and RAWLINSON SCF (2003). Methods for analyzing bone cell responses to mechanical loading using in vitro monolayer and organ culture models. Bone Research Protocols (Methods in Molecular Medicine) , Editors: RALSTON MHS. Humana Press  10.1385/1-59259-366-6:399

2002

Jessop HL, Rawlinson SCF, Pitsillides AA and Lanyon LE (2002). Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone  vol. 31, (1) 186-194. 10.1016/s8756-3282(02)00797-4
Pitsillides AA, Rawlinson SCF, Wright CPD, Bredl J, Mosley JR and Lanyon LE (2002). Differing architectural designs achieve similar load-bearing resistance in genetically distinct strains of chick. J Bone Miner Res  vol. 17, (5) 953-953.
Cheng MZ, Rawlinson SCF, Pitsillides AA, Zaman G, Mohan S, Baylink DJ and Lanyon LE (2002). Human osteoblasts' proliferative responses to strain and 17 beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. J Bone Miner Res  vol. 17, (4) 593-602. 10.1359/jbmr.2002.17.4.593

2000

Rawlinson SC, Wheeler-Jones CP and Lanyon LE (2000). Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2). 10.1016/s8756-3282(00)00323-9

1999

Cheng MZ, Zaman G, Rawlinson SCF, Mohan S, Baylink DJ and Lanyon LE (1999). ROS cells proliferate in response to estrogen through IGF-I and mechanical strain through IGF-II. J Bone Miner Res  vol. 14, (6) 1032-1032.
Cheng M, Zaman G, Rawlinson SC, Mohan S, Baylink DJ and Lanyon LE (1999). Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I. 10.1359/jbmr.1999.14.10.1742
Pitsillides AA, Rawlinson SC, Mosley JR and Lanyon LE (1999). Bone's early responses to mechanical loading differ in distinct genetic strains of chick: selection for enhanced growth reduces skeletal adaptability. 10.1359/jbmr.1999.14.6.980
Zaman G, Pitsillides AA, Rawlinson SC, Suswillo RF, Mosley JR, Cheng MZ, Platts LA, Hukkanen M, Polak JM and Lanyon LE (1999). Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. 10.1359/jbmr.1999.14.7.1123

1998

Rawlinson SC, Zaman G, Mosley JR, Pitsillides AA and Lanyon LE (1998). Heme oxygenase isozymes in bone: induction of HO-1 mRNA following physiological levels of mechanical loading in vivo. 10.1016/s8756-3282(98)00125-2

1997

Rawlinson SCF, Pitsillides AA, Zaman G and Lanyon LE (1997). Effect of exogenous carbon monoxide on loading-related pre-osteogenic responses. J Bone Miner Res  vol. 12, (9) P13-P13.
Cheng MZ, Zaman G, Rawlinson SC, Pitsillides AA, Suswillo RF and Lanyon LE (1997). Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae. 10.1359/jbmr.1997.12.9.1424
Hukkanen M, Pitsillides AA, Rawlinson SCF, Suswillo R, Zaman G, Platts LAM, Polak JM and Lanyon LE (1997). A putative role for osteocyte eNOS-derived NO in adaptive bone remodelling. J Pathol  vol. 181, A42-A42.

1996

Rawlinson SCF, Zaman G, Pitsillides AA and Lanyon LE (1996). A possible role for carbon monoxide in the adaptive response of bone cells to dynamic mechanical loading. J Bone Miner Res  vol. 11, (11) P8-P8.
Cheng MZ, Zaman G, Rawlinson SC, Suswillo RF and Lanyon LE (1996). Mechanical loading and sex hormone interactions in organ cultures of rat ulna. 10.1002/jbmr.5650110411
Rawlinson SC, Pitsillides AA and Lanyon LE (1996). Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. 10.1016/s8756-3282(96)00260-8

1995

PITSILLIDES AA, RAWLINSON SCF, SUSWILLO RFL, ZAMAN G, NIJWEIDE PI and LANYON LE (1995). MECHANICAL STRAIN-INDUCED NITRIC-OXIDE PRODUCTION BY OSTEOBLASTS AND OSTEOCYTES. J Bone Miner Res  vol. 10, S217-S217.
RAWLINSON SCF, PITSILLIDES AA and LANYON LE (1995). MECHANODEPENDENT SIGNALING PATHWAYS IN OSTEOCYTES AND OSTEOBLASTS. J Bone Miner Res  vol. 10, S342-S342.
CHENG MZ, ZAMAN G, RAWLINSON SCF, SUSWILLO RFL and LANYON LE (1995). MECHANICAL LOADING, PROSTAGLANDIN AND SEX-HORMONE INTERACTIONS IN MALE AND FEMALE RAT ULNAE IN CULTURE. J Bone Miner Res  vol. 10, S342-S342.
Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G and Lanyon LE (1995). Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling? 10.1096/fasebj.9.15.8529841
Rawlinson SC, Mosley JR, Suswillo RF, Pitsillides AA and Lanyon LE (1995). Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. 10.1002/jbmr.5650100813

1993

Rawlinson SC, Mohan S, Baylink DJ and Lanyon LE (1993). Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. 10.1007/BF01351837

1992

RAWLINSON SCF, MOHAN S, BAYLINK DJ and LANYON LE (1992). LOAD-RELATED OSTEOGENESIS, PROSTACYCLIN AND IGF-II. J Bone Miner Res  vol. 7, S141-S141.

1991

Rawlinson SC, el-Haj AJ, Minter SL, Tavares IA, Bennett A and Lanyon LE (1991). Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? 10.1002/jbmr.5650061212

1990

EL-HAJ AJ, MINTER SL, RAWLINSON SCF, SUSWILLO RFL and LANYON LE (1990). Cellular responses to mechanical loading in vitro. J Bone Miner Res  vol. 5, (9) 923-932. 10.1002/jbmr.5650050905