Dr Simon Rawlinson
Reader in Dental Hard Tissue Biology
Dentistry
Queen Mary University of London
Queen Mary University of London
Research
Bone, Mechanobiology, Strain, Shear
Interests
Interest in further developing in vitro models to best replicate forces engendered in bone by mechanical loadingPublications
Publications of specific relevance to Predictive in vitro Models2023
Al-Noaman A and Rawlinson SCF (2023). A novel bioactive glass/graphene oxide composite coating for a polyether ether ketone-based dental implant. European Journal of Oral Sciences vol. 131, (2) 10.1111/eos.129152022
Al-Noaman A, Rawlinson SCF and Hill RG (2022). MgF2020
Rawlinson SCF (2020). Mechanobiology Journal
—Welcome Editorial. Mechanobiology Journal vol. 1, 1-1. 10.32371/mbj/2360792019
Caetano-Silva SP, Novicky A, Javaheri B, Rawlinson SCF and Pitsillides AA (2019). Using cell and organ culture models to analyze responses of bone cells to mechanical stimulation. Methods in Molecular Biology 10.1007/978-1-4939-8997-3_62018
Gharibi B, Ghuman MS, Cama G, Rawlinson SCF, Grigoriadis AE and Hughes FJ (2018). Site-specific differences in osteoblast phenotype, mechanical loading response and estrogen receptor-related gene expression. Molecular and Cellular Endocrinology vol. 477, 140-147. 10.1016/j.mce.2018.06.011Liu J, Zheng F, Rawlinson SCF, Fortune F and Kim DG (2018). Bone biology and bioactive glass in bone regeneration. Bone Regeneration: Concepts, Clinical Aspects and Future Directions 2017
Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE and Pitsillides AA (2017). Corrigendum: Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. Cell Biochem Funct vol. 35, (4) 244-244. 10.1002/cbf.3268Huang M, Hill RG and Rawlinson SCF (2017). Zinc bioglasses regulate mineralization in human dental pulp stem cells. Elsevier Dental Materials vol. 33, (5) 543-552. 10.1016/j.dental.2017.03.011RAWLINSON SCF (2017). Mechanical responsiveness of distinct skeletal elements – possible exploitation of low weight-bearing bone. Mechanobiology: Exploitation For Medical Benefit Wiley Blackwell 10.1002/9781118966174.ch8Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE and Pitsillides AA (2017). Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes. Cell Biochemistry and Function vol. 35, (1) 56-65. 10.1002/cbf.32452016
Rawlinson SCF (2016). Mechanical Responsiveness of Distinct Skeletal Elements. Mechanobiology 10.1002/9781118966174.ch8Liu J, Rawlinson S, Hill R and FORTUNE F (2016). Fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects. Elsevier Dental Materials vol. 32, (10) e221-e237. 10.1016/j.dental.2016.07.003Huang M, Hill RG and Rawlinson SCF (2016). Strontium (Sr) elicits odontogenic differentiation of human dental pulp stem cells (hDPSCs): A therapeutic role for Sr in dentine repair? Elsevier Acta Biomaterialia 10.1016/j.actbio.2016.04.037Liu J, Rawlinson SCF, Hill RG and Fortune F (2016). Strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects. Dental Materials vol. 32, (3) 412-422. 10.1016/j.dental.2015.12.0132015
Stachewicz U, Qiao T, Rawlinson SCF, Veiga Almeida F, Li WQ, Cattell M and Barber AH (2015). Microscopy and supporting data for osteoblast integration within an electrospun fibrous network. Data in Brief vol. 5, 775-781. 10.1016/j.dib.2015.10.009Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M and Barber AH (2015). 3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration. Elsevier/Science Direct Acta Biomaterialia vol. 27, 88-100. 10.1016/j.actbio.2015.09.003Memarzadeh K, Sharili AS, Huang J, Rawlinson SCF and Allaker RP (2015). Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants. Journal of Biomedical Materials Research - Part A vol. 103, (3) 981-989. 10.1002/jbm.a.352412014
Memarzadeh K, Sharili AS, Huang J, Rawlinson SCF and Allaker RP (2014). Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants. Journal of Biomedical Materials Research - Part A 10.1002/jbm.a.35241Huang M, Rawlinson SCF and Hill RG (2014). Interactions of strontium with the dentine-pulp complex. Dental Materials vol. 30, e176-e177. 10.1016/j.dental.2014.08.3542013
Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Behaviour of osteoblast-like cells cultured on titanium coated with FA/glass composite coating. Journal of Non-Crystalline Solids vol. 364, 85-91. 10.1016/j.jnoncrysol.2012.12.041Kingsmill VJ, McKay IJ, Ryan P, Ogden MR and Rawlinson SCF (2013). Gene expression profiles of mandible reveal features of both calvarial and ulnar bones in the adult rat. J Dent vol. 41, (3) 258-264. 10.1016/j.jdent.2012.11.010Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA addition on bioactivity of bioactive glass coating for titanium dental implant: Part II— Composite coating. Journal of Non-Crystalline Solids vol. 364, 99-106. 10.1016/j.jnoncrysol.2012.11.046Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG (2013). Effect of FA on bioactivity of bioactive glass coating for titanium dental implant. Part I: Composite powder. Journal of Non-Crystalline Solids vol. 364, 92-98. 10.1016/j.jnoncrysol.2012.11.051Al-Noaman A, Rawlinson SCF and Hill RG (2013). Bioactive glass-stoichimetric wollastonite glass alloys to reduce TEC of bioactive glass coatings for dental implants. Materials Letters vol. 94, 69-71. 10.1016/j.matlet.2012.12.0172012
Al-Noaman A, Rawlinson SCF and Hill RG (2012). The role of MgO on thermal properties, structure and bioactivity of bioactive glass coating for dental implants. Journal of Non-Crystalline Solids vol. 358, (22) 3019-3027. 10.1016/j.jnoncrysol.2012.07.039Al-Noaman A, Rawlinson SCF and Hill RG (2012). The influence of CaF2 content on the physical properties and apatite formation of bioactive glass coatings for dental implants. Journal of Non-Crystalline Solids vol. 358, (15) 1850-1858. 10.1016/j.jnoncrysol.2012.05.039Pitsillides AA and Rawlinson SCF (2012). Using cell and organ culture models to analyze responses of bone cells to mechanical stimulation. Methods in Molecular Biology vol. 816, 593-619. 10.1007/978-1-61779-415-5_372010
Kingsmill VJ, Boyde A, Davis GR, Howell PGT and Rawlinson SCF (2010). Changes in bone mineral and matrix in response to a soft diet. J Dent Res vol. 89, (5) 510-514. 10.1177/00220345103629702009
Rawlinson SCF, Mckay IJ, Ghuman M, Wellmann C, Ryan P, Prajaneh S, Zaman G, Hughes FJ and Kingsmill VJ (2009). Adult Rat Bones Maintain Distinct Regionalized Expression of Markers Associated with Their Development. Plos One vol. 4, (12) 10.1371/journal.pone.0008358Rawlinson SCF, Murray DH, Mosley JR, Wright CDP, Bredl JC, Saxon LK, Loveridge N, Leterrier C, Constantin P, Farquharson C and Pitsillides AA (2009). Genetic selection for fast growth generates bone architecture characterised by enhanced periosteal expansion and limited consolidation of the cortices but a diminution in the early responses to mechanical loading. Bone vol. 45, (2) 357-366. 10.1016/j.bone.2009.04.243Rawlinson SCF, Boyde A, Davis GR, Howell PGT, Hughes FJ and Kingsmill VJ (2009). Ovariectomy vs. Hypofunction: Their Effects on Rat Mandibular Bone. J Dent Res vol. 88, (7) 615-620. 10.1177/0022034509340132Rawlinson SCF, McKay IJ, Ghuman M, Wellmann C, Hughes FJ and Kingsmill VJ (2009). POST-MENOPAUSAL OSTEOPOROSIS-RESISTANT SKULL BONES – GENOTYPICALLY DISTINCT FROM OSTEOPOROTIC-SUSCEPTIBLE LIMB BONE. Maturitas vol. 63, 10.1016/s0378-5122(09)70152-52008
Simon DWN, Clarkin CE, Das-Gupta V, Rawlinson SCF, Emery RJ and Pitsillides AA (2008). Identifying the cellular basis for reimplantation failure in repair of the rotator cuff. J Bone Joint Surg Br vol. 90B, (5) 680-684. 10.1302/0301-620X.90B5.200132005
De Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE and Pitsillides AA (2005). Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element. Bone vol. 37, (6) 810-818. 10.1016/j.bone.2005.07.0222004
Chambler A, Rawlinson S, Emery R and Pitsillides A (2004). Quantitative cytochemical evidence for local increases in bone turnover at the acromial enthesis of the human coracoacromial ligament. Journal of Rheumatology vol. 31, (11) 2216-2225. Jessop HL, Suswillo RFL, Rawlinson SCF, Zaman G, Lee K, Das-Gupta V, Pitsillides AA and Lanyon LE (2004). Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain. J Bone Miner Res vol. 19, (6) 938-946. 10.1359/JBMR.2003
Pitsillides AA, Das-Gupta V, Simon D and Rawlinson SCF (2003). Methods for Analyzing Bone Cell Responses to Mechanical Loading Using In Vitro Monolayer and Organ Culture Models. Bone Research Protocols 10.1385/1-59259-366-6:399PITSILLIDES AA, DAS-GUPTA V, SIMON D and RAWLINSON SCF (2003). Methods for analyzing bone cell responses to mechanical loading using in vitro monolayer and organ culture models. Bone Research Protocols (Methods in Molecular Medicine) , Editors: RALSTON MHS. Humana Press 10.1385/1-59259-366-6:3992002
Jessop HL, Rawlinson SCF, Pitsillides AA and Lanyon LE (2002). Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways. Bone vol. 31, (1) 186-194. 10.1016/s8756-3282(02)00797-4Pitsillides AA, Rawlinson SCF, Wright CPD, Bredl J, Mosley JR and Lanyon LE (2002). Differing architectural designs achieve similar load-bearing resistance in genetically distinct strains of chick. J Bone Miner Res vol. 17, (5) 953-953. Cheng MZ, Rawlinson SCF, Pitsillides AA, Zaman G, Mohan S, Baylink DJ and Lanyon LE (2002). Human osteoblasts' proliferative responses to strain and 17 beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I. J Bone Miner Res vol. 17, (4) 593-602. 10.1359/jbmr.2002.17.4.5932000
Rawlinson SC, Wheeler-Jones CP and Lanyon LE (2000). Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2). 10.1016/s8756-3282(00)00323-91999
Cheng MZ, Zaman G, Rawlinson SCF, Mohan S, Baylink DJ and Lanyon LE (1999). ROS cells proliferate in response to estrogen through IGF-I and mechanical strain through IGF-II. J Bone Miner Res vol. 14, (6) 1032-1032. Cheng M, Zaman G, Rawlinson SC, Mohan S, Baylink DJ and Lanyon LE (1999). Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I. 10.1359/jbmr.1999.14.10.1742Pitsillides AA, Rawlinson SC, Mosley JR and Lanyon LE (1999). Bone's early responses to mechanical loading differ in distinct genetic strains of chick: selection for enhanced growth reduces skeletal adaptability. 10.1359/jbmr.1999.14.6.980Zaman G, Pitsillides AA, Rawlinson SC, Suswillo RF, Mosley JR, Cheng MZ, Platts LA, Hukkanen M, Polak JM and Lanyon LE (1999). Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes. 10.1359/jbmr.1999.14.7.11231998
Rawlinson SC, Zaman G, Mosley JR, Pitsillides AA and Lanyon LE (1998). Heme oxygenase isozymes in bone: induction of HO-1 mRNA following physiological levels of mechanical loading in vivo. 10.1016/s8756-3282(98)00125-21997
Rawlinson SCF, Pitsillides AA, Zaman G and Lanyon LE (1997). Effect of exogenous carbon monoxide on loading-related pre-osteogenic responses. J Bone Miner Res vol. 12, (9) P13-P13. Cheng MZ, Zaman G, Rawlinson SC, Pitsillides AA, Suswillo RF and Lanyon LE (1997). Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae. 10.1359/jbmr.1997.12.9.1424Hukkanen M, Pitsillides AA, Rawlinson SCF, Suswillo R, Zaman G, Platts LAM, Polak JM and Lanyon LE (1997). A putative role for osteocyte eNOS-derived NO in adaptive bone remodelling. J Pathol vol. 181, A42-A42. 1996
Pitsillides AA, Rawlinson SCF, Suswillo R, Zaman G, Hukkanen M, Platts L, Polak JM and Lanyon LE (1996). A putative role for osteocyte eNOS-derived NO in adaptive bone (re)modelling: An extension to an endothelial paradigm. International Journal of Experimental Pathology vol. 77, (6) Pitsillides AA, Rawlinson SCF and Lanyon LE (1996). P10. Early responses to mechanical load in selectively-bred embryonic chicks differ. Bone vol. 19, (6) 10.1016/s8756-3282(97)84322-0Rawlinson SCF, Zaman G, Pitsillides AA and Lanyon LE (1996). A possible role for carbon monoxide in the adaptive response of bone cells to dynamic mechanical loading. J Bone Miner Res vol. 11, (11) P8-P8. Cheng MZ, Zaman G, Rawlinson SC, Suswillo RF and Lanyon LE (1996). Mechanical loading and sex hormone interactions in organ cultures of rat ulna. 10.1002/jbmr.5650110411Rawlinson SC, Pitsillides AA and Lanyon LE (1996). Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain. 10.1016/s8756-3282(96)00260-81995
Rawlinson SCF, Pitsillides AA and Lanyon LE (1995). Strain measurement by bone cells during mechanical loading. Bone vol. 17, (3) 10.1016/8756-3282(95)97349-kPITSILLIDES AA, RAWLINSON SCF, SUSWILLO RFL, ZAMAN G, NIJWEIDE PI and LANYON LE (1995). MECHANICAL STRAIN-INDUCED NITRIC-OXIDE PRODUCTION BY OSTEOBLASTS AND OSTEOCYTES. J Bone Miner Res vol. 10, S217-S217. RAWLINSON SCF, PITSILLIDES AA and LANYON LE (1995). MECHANODEPENDENT SIGNALING PATHWAYS IN OSTEOCYTES AND OSTEOBLASTS. J Bone Miner Res vol. 10, S342-S342. CHENG MZ, ZAMAN G, RAWLINSON SCF, SUSWILLO RFL and LANYON LE (1995). MECHANICAL LOADING, PROSTAGLANDIN AND SEX-HORMONE INTERACTIONS IN MALE AND FEMALE RAT ULNAE IN CULTURE. J Bone Miner Res vol. 10, S342-S342. Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G and Lanyon LE (1995). Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling? 10.1096/fasebj.9.15.8529841Rawlinson SC, Mosley JR, Suswillo RF, Pitsillides AA and Lanyon LE (1995). Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain. 10.1002/jbmr.56501008131993
Rawlinson SC, Mohan S, Baylink DJ and Lanyon LE (1993). Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture. 10.1007/BF013518371992
RAWLINSON SCF, MOHAN S, BAYLINK DJ and LANYON LE (1992). LOAD-RELATED OSTEOGENESIS, PROSTACYCLIN AND IGF-II. J Bone Miner Res vol. 7, S141-S141. 1991
Rawlinson SC, el-Haj AJ, Minter SL, Tavares IA, Bennett A and Lanyon LE (1991). Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling? 10.1002/jbmr.56500612121990
EL-HAJ AJ, MINTER SL, RAWLINSON SCF, SUSWILLO RFL and LANYON LE (1990). Cellular responses to mechanical loading in vitro. J Bone Miner Res vol. 5, (9) 923-932. 10.1002/jbmr.5650050905Grants
Lucideon-QMUL Cell testing to assist development of novel biomaterialsHing K, Rawlinson S and Shepherd D
£249,854 Innovate UK (15-03-2021 - 14-09-2023)
Preclinical Development of a Novel Bioactive Glass Cement for Bone Graft Substitution in DentistryRawlinson SCF and Shahdad SA
£543,204 Medical Research Council (01-06-2015 - 01-11-2018)