Prof Simon Rawlinson

Simon Rawlinson

Professor of Dental Hard Tissue Biology

Dentistry
Queen Mary University of London
020 7882 7139
www.qmul.ac.uk/dentistry/people/profiles/drsimoncharlesfieldingrawlinson.html

Research

Bone, Mechanobiology, Strain, Shear

Musculoskeletal Models

Interests

Interest in further developing in vitro models to best replicate forces engendered in bone by mechanical loading

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Osseointegration of Anodized vs. Sandblasted Implant Surfaces in a Guided Bone Regeneration Acute Dehiscence‐Type Defect: An In Vivo Experimental Mandibular Minipig Model
Shahdad S, Rawlinson S, Razaghi N, Patankar A, Patel M, Roccuzzo M, Gill T
Clinical Oral Implants Research, Wiley vol. 36 (1), 127-141.  
10-10-2024
A bioactive and anti-bacterial nano-sized zirconium phosphate/GO (nZrP/GO) composite: Potential use as a coating for dental implants?
Al-Noaman A, Rawlinson SCF
Dental Materials, Elsevier 
08-08-2024
Primary stability and osseointegration comparing a novel tapered design tissue‐level implant with a parallel design tissue‐level implant. An experimental in vivo study
Gill T, Kühl S, Rawlinson S, Pippenger B, Bellon B, Shahdad S
Clinical Oral Implants Research, Wiley vol. 35 (9), 1114-1127.  
31-05-2024
Development of a Novel Formulation of Bioactive Glass Based Calcium Phosphate Cement for Bone Grafting
D'Onofrio A, Hill RG, Kent NW, Rawlinson SCF, Shahdad SA
Advanced Functional Materials, Wiley vol. 34 (36) 
08-04-2024

2023

Titanium Dioxide/Graphene Oxide Composite Coatings for 316 Stainless Steel Dental Implants.
Al-Noaman AS, Rawlinson SF
European Journal of Prosthodontics and Restorative Dentistry vol. 31 (4), 358-372.  
30-11-2023
Polyether ether ketone coated with nanohydroxyapatite/graphene oxide composite promotes bioactivity and antibacterial activity at the surface of the material
Al‐Noaman A, Rawlinson SCF
European Journal of Oral Sciences, Wiley vol. 131 (5-6) 
02-08-2023
A novel bioactive glass/graphene oxide composite coating for a polyether ether ketone‐based dental implant
Al‐Noaman A, Rawlinson SCF
European Journal of Oral Sciences, Wiley vol. 131 (2) 
27-01-2023

2022

OSTEOGENIC ACTIVITY OF ACTIFUSE™ IS NOT ENHANCED BY PRE-ADSORBED BMP2
Kohnken-Sawall J, Rawlinson SCF, Hing KA
 
01-01-2022

2021

MgF2- containing glasses as a coating for titanium dental implant. I- Glass powder
Al-Noaman A, Rawlinson SCF, Hill RG
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 125 
01-11-2021

2020

Mechanobiology Journal —Welcome Editorial
Rawlinson SCF
Mechanobiology Journal, Bendola S.P.R.L - Bvba vol. 1, 1-1.  
01-01-2020

2019

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation
Caetano-Silva SP, Novicky A, Javaheri B, Rawlinson SCF, Pitsillides AA
In Bone Research Protocols, Springer Nature 99-128.  
01-01-2019

2018

Bone biology and bioactive glass in bone regeneration
Liu J, Zheng F, Rawlinson SCF, Fortune F, Kim DG
In Bone Regeneration: Concepts, Clinical Aspects and Future Directions 255-280.  
12-07-2018
Site-specific differences in osteoblast phenotype, mechanical loading response and estrogen receptor-related gene expression
Gharibi B, Ghuman MS, Cama G, Rawlinson SCF, Grigoriadis AE, Hughes FJ
Molecular and Cellular Endocrinology, Elsevier vol. 477, 140-147.  
19-06-2018

2017

Corrigendum: Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes.
Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE, Pitsillides AA
 
01-06-2017
Zinc bioglasses regulate mineralization in human dental pulp stem cells.
Huang M, Hill RG, Rawlinson SCF
Dental Materials, Elsevier vol. 33 (5), 543-552.  
31-03-2017
Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes
Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE, Pitsillides AA
Cell Biochemistry and Function, Wiley vol. 35 (1), 56-65.  
01-01-2017
Mechanical responsiveness of distinct skeletal elements – possible exploitation of low weight-bearing bone
RAWLINSON SCF
In Mechanobiology: Exploitation For Medical Benefit, Wiley Blackwell 131-142.  
01-01-2017

2016

Mechanical Responsiveness of Distinct Skeletal Elements
Rawlinson SCF
In Mechanobiology, Wiley 131-142.  
23-12-2016
Mechanobiology: Exploitation for Medical Benefit
Rawlinson SCF
 
07-11-2016
Preface
Rawlinson SCF
 
07-11-2016
Fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects
Liu J, Rawlinson S, Hill R, FORTUNE F
Dental Materials, Elsevier vol. 32 (10), e221-e237.  
25-07-2016
Strontium (Sr) elicits odontogenic differentiation of human dental pulp stem cells (hDPSCs): A therapeutic role for Sr in dentine repair?
Huang M, Hill RG, Rawlinson SCF
Acta Biomaterialia, Elsevier 
27-04-2016
Strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects
Liu J, Rawlinson SCF, Hill RG, Fortune F
Dental Materials, Elsevier vol. 32 (3), 412-422.  
08-01-2016

2015

3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration
Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li WQ, Cattell M, Barber AH
Acta Biomaterialia vol. 27, 88-100.  
01-11-2015
Microscopy and supporting data for osteoblast integration within an electrospun fibrous network
Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M, Barber AH
Data in Brief, Elsevier vol. 5, 775-781.  
16-10-2015
3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration
Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M, Barber AH
Acta Biomaterialia, Elsevier/Science Direct vol. 27, 88-100.  
05-09-2015
Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants
Memarzadeh K, Sharili AS, Huang J, Rawlinson SCF, Allaker RP
Journal of Biomedical Materials Research - Part A vol. 103 (3), 981-989.  
01-03-2015

2014

Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants
Memarzadeh K, Sharili AS, Huang J, Rawlinson SCF, Allaker RP
Journal of Biomedical Materials Research Part A, Wiley vol. 103 (3), 981-989.  
04-06-2014
Interactions of strontium with the dentine-pulp complex
Huang M, Rawlinson SCF, Hill RG
Dental Materials, Elsevier vol. 30, e176-e177.  
01-01-2014

2013

Gene expression profiles of mandible reveal features of both calvarial and ulnar bones in the adult rat.
Kingsmill VJ, McKay IJ, Ryan P, Ogden MR, Rawlinson SCF
J Dent vol. 41 (3), 258-264.  
01-03-2013
Effect of FA addition on bioactivity of bioactive glass coating for titanium dental implant: Part II— Composite coating
Al-Noaman A, Karpukhina N, Rawlinson SCF, Hill RG
Journal of Non Crystalline Solids vol. 364, 99-106.  
01-03-2013
Effect of FA on bioactivity of bioactive glass coating for titanium dental implant. Part I: Composite powder
Al-Noaman A, Karpukhina N, Rawlinson SCF, Hill RG
Journal of Non Crystalline Solids vol. 364, 92-98.  
01-03-2013
Bioactive glass-stoichimetric wollastonite glass alloys to reduce TEC of bioactive glass coatings for dental implants
Al-Noaman A, Rawlinson SCF, Hill RG
Materials Letters vol. 94, 69-71.  
01-01-2013
Behaviour of osteoblast-like cells cultured on titanium coated with FA/glass composite coating
Al-Noaman A, Karpukhina N, Rawlinson SCF, Hill RG
Journal of Non-Crystalline Solids vol. 364, 85-91.  
01-01-2013

2012

The influence of CaF2 content on the physical properties and apatite formation of bioactive glass coatings for dental implants
Al-Noaman A, Rawlinson SCF, Hill RG
Journal of Non-Crystalline Solids vol. 358 (15), 1850-1858.  
01-01-2012
The role of MgO on thermal properties, structure and bioactivity of bioactive glass coating for dental implants
Al-Noaman A, Rawlinson SCF, Hill RG
Journal of Non-Crystalline Solids vol. 358 (22), 3019-3027.  
01-01-2012

2011

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation
Pitsillides AA, Rawlinson SCF
Methods in Molecular Biology, Springer Nature vol. 816, 593-619.  
14-10-2011

2010

Changes in bone mineral and matrix in response to a soft diet.
Kingsmill VJ, Boyde A, Davis GR, Howell PGT, Rawlinson SCF
J Dent Res vol. 89 (5), 510-514.  
01-05-2010

2009

Adult Rat Bones Maintain Distinct Regionalized Expression of Markers Associated with Their Development
Rawlinson SCF, Mckay IJ, Ghuman M, Wellmann C, Ryan P, Prajaneh S, Zaman G, Hughes FJ et al.
Plos One vol. 4 (12) 
21-12-2009
Genetic selection for fast growth generates bone architecture characterised by enhanced periosteal expansion and limited consolidation of the cortices but a diminution in the early responses to mechanical loading
Rawlinson SCF, Murray DH, Mosley JR, Wright CDP, Bredl JC, Saxon LK, Loveridge N, Leterrier C et al.
Bone vol. 45 (2), 357-366.  
01-08-2009
Ovariectomy vs. Hypofunction: Their Effects on Rat Mandibular Bone
Rawlinson SCF, Boyde A, Davis GR, Howell PGT, Hughes FJ, Kingsmill VJ
J Dent Res vol. 88 (7), 615-620.  
01-07-2009
POST-MENOPAUSAL OSTEOPOROSIS-RESISTANT SKULL BONES – GENOTYPICALLY DISTINCT FROM OSTEOPOROTIC-SUSCEPTIBLE LIMB BONE
Rawlinson SCF, McKay IJ, Ghuman M, Wellmann C, Hughes FJ, Kingsmill VJ
Maturitas, Elsevier vol. 63 
01-05-2009

2008

Primary osteoblasts and bone matrix of bones with different functions have distinct characteristics
Rawlinson SCF, Zaman G, McKay IJ, Ghuman M, Hughes FJ, Kingsmill VJ
 
01-07-2008
Identifying the cellular basis for reimplantation failure in repair of the rotator cuff
Simon DWN, Clarkin CE, Das-Gupta V, Rawlinson SCF, Emery RJ, Pitsillides AA
J Bone Joint Surg Br vol. 90B (5), 680-684.  
01-05-2008

2005

Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element
De Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE, Pitsillides AA
Bone vol. 37 (6), 810-818.  
01-12-2005
Osteocyte density in bone: The effect of hormonal or mechanical disruption
Rawlinson SCF, Hughes FJ, Kingsmill VJ
 
01-07-2005
Sulphated glycosaminoglycan staining intensity in bone: Effect of a change in mechanical loads
Rawlinson SCF, Hughes FJ, Kingsmill VJ
 
01-07-2005

2004

Quantitative cytochemical evidence for local increases in bone turnover at the acromial enthesis of the human coracoacromial ligament.
Chambler A, Rawlinson S, Emery R, Pitsillides A
The Journal of Rheumatology vol. 31 (11), 2216-2225.  
01-11-2004
Non-invasive axial loading of the murine tibia induces increases in cortical bone formation accompanied by modification in trabecular bone architecture: A novel model for in vivo loading studies.
de Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE, Pitsillides AA
 
01-10-2004
Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain
Jessop HL, Suswillo RFL, Rawlinson SCF, Zaman G, Lee K, Das-Gupta V, Pitsillides AA, Lanyon LE
J Bone Miner Res vol. 19 (6), 938-946.  
01-06-2004

2003

Methods for Analyzing Bone Cell Responses to Mechanical Loading Using In Vitro Monolayer and Organ Culture Models
Pitsillides AA, Das-Gupta V, Simon D, Rawlinson SCF
In Bone Research Protocols, Springer Nature 399-422.  
01-01-2003
Methods for analyzing bone cell responses to mechanical loading using in vitro monolayer and organ culture models
PITSILLIDES AA, DAS-GUPTA V, SIMON D, RAWLINSON SCF
In Bone Research Protocols (Methods in Molecular Medicine), Humana Press 399-423.  
01-01-2003

2002

Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways
Jessop HL, Rawlinson SCF, Pitsillides AA, Lanyon LE
Bone vol. 31 (1), 186-194.  
01-07-2002
Differing architectural designs achieve similar load-bearing resistance in genetically distinct strains of chick
Pitsillides AA, Rawlinson SCF, Wright CPD, Bredl J, Mosley JR, Lanyon LE
J Bone Miner Res vol. 17 (5), 953-953.  
01-05-2002
Human osteoblasts' proliferative responses to strain and 17 beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I
Cheng MZ, Rawlinson SCF, Pitsillides AA, Zaman G, Mohan S, Baylink DJ, Lanyon LE
J Bone Miner Res vol. 17 (4), 593-602.  
01-04-2002

2001

Mechanical strain rapidly activates osteoblastic protein kinase B (PKB): An upstream modulator of eNOS activity.
Grewal TS, Tolley RJ, Rawlinson SCF, Lanyon LE, Skerry TM
 
01-09-2001

2000

Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2).
Rawlinson SC, Wheeler-Jones CP, Lanyon LE
vol. 27 (2), 241-247.  
01-01-2000

1999

ROS cells proliferate in response to estrogen through IGF-I and mechanical strain through IGF-II.
Cheng MZ, Zaman G, Rawlinson SCF, Mohan S, Baylink DJ, Lanyon LE
J Bone Miner Res vol. 14 (6), 1032-1032.  
01-06-1999
Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I.
Cheng M, Zaman G, Rawlinson SC, Mohan S, Baylink DJ, Lanyon LE
vol. 14 (10), 1742-1750.  
01-01-1999
Bone's early responses to mechanical loading differ in distinct genetic strains of chick: selection for enhanced growth reduces skeletal adaptability.
Pitsillides AA, Rawlinson SC, Mosley JR, Lanyon LE
vol. 14 (6), 980-987.  
01-01-1999
Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes.
Zaman G, Pitsillides AA, Rawlinson SC, Suswillo RF, Mosley JR, Cheng MZ, Platts LA, Hukkanen M et al.
vol. 14 (7), 1123-1131.  
01-01-1999

1998

Heme oxygenase isozymes in bone: induction of HO-1 mRNA following physiological levels of mechanical loading in vivo.
Rawlinson SC, Zaman G, Mosley JR, Pitsillides AA, Lanyon LE
vol. 23 (5), 433-436.  
01-01-1998

1997

Effect of exogenous carbon monoxide on loading-related pre-osteogenic responses
Rawlinson SCF, Pitsillides AA, Zaman G, Lanyon LE
J Bone Miner Res vol. 12 (9), P13-P13.  
01-09-1997
Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae.
Cheng MZ, Zaman G, Rawlinson SC, Pitsillides AA, Suswillo RF, Lanyon LE
vol. 12 (9), 1424-1430.  
01-01-1997
A putative role for osteocyte eNOS-derived NO in adaptive bone remodelling
Hukkanen M, Pitsillides AA, Rawlinson SCF, Suswillo R, Zaman G, Platts LAM, Polak JM, Lanyon LE
J Pathol vol. 181, A42-A42.  
01-01-1997

1996

A putative role for osteocyte eNOS-derived NO in adaptive bone (re)modelling: An extension to an endothelial paradigm
Pitsillides AA, Rawlinson SCF, Suswillo R, Zaman G, Hukkanen M, Platts L, Polak JM, Lanyon LE
International Journal of Experimental Pathology vol. 77 (6) 
01-12-1996
P10. Early responses to mechanical load in selectively-bred embryonic chicks differ
Pitsillides AA, Rawlinson SCF, Lanyon LE
Bone, Elsevier vol. 19 (6) 
01-12-1996
A possible role for carbon monoxide in the adaptive response of bone cells to dynamic mechanical loading
Rawlinson SCF, Zaman G, Pitsillides AA, Lanyon LE
J Bone Miner Res vol. 11 (11), P8-P8.  
01-11-1996
Mechanical loading and sex hormone interactions in organ cultures of rat ulna.
Cheng MZ, Zaman G, Rawlinson SC, Suswillo RF, Lanyon LE
vol. 11 (4), 502-511.  
01-01-1996
Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain.
Rawlinson SC, Pitsillides AA, Lanyon LE
vol. 19 (6), 609-614.  
01-01-1996

1995

Strain measurement by bone cells during mechanical loading
Rawlinson SCF, Pitsillides AA, Lanyon LE
Bone, Elsevier vol. 17 (3) 
01-09-1995
MECHANICAL STRAIN-INDUCED NITRIC-OXIDE PRODUCTION BY OSTEOBLASTS AND OSTEOCYTES
PITSILLIDES AA, RAWLINSON SCF, SUSWILLO RFL, ZAMAN G, NIJWEIDE PI, LANYON LE
J Bone Miner Res vol. 10, S217-S217.  
01-08-1995
MECHANODEPENDENT SIGNALING PATHWAYS IN OSTEOCYTES AND OSTEOBLASTS
RAWLINSON SCF, PITSILLIDES AA, LANYON LE
J Bone Miner Res vol. 10, S342-S342.  
01-08-1995
MECHANICAL LOADING, PROSTAGLANDIN AND SEX-HORMONE INTERACTIONS IN MALE AND FEMALE RAT ULNAE IN CULTURE
CHENG MZ, ZAMAN G, RAWLINSON SCF, SUSWILLO RFL, LANYON LE
J Bone Miner Res vol. 10, S342-S342.  
01-08-1995
Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling?
Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G, Lanyon LE
vol. 9 (15), 1614-1622.  
01-01-1995
Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain.
Rawlinson SC, Mosley JR, Suswillo RF, Pitsillides AA, Lanyon LE
vol. 10 (8), 1225-1232.  
01-01-1995

1993

Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture.
Rawlinson SC, Mohan S, Baylink DJ, Lanyon LE
vol. 53 (5), 324-329.  
01-01-1993

1992

LOAD-RELATED OSTEOGENESIS, PROSTACYCLIN AND IGF-II
RAWLINSON SCF, MOHAN S, BAYLINK DJ, LANYON LE
J Bone Miner Res vol. 7, S141-S141.  
01-08-1992

1991

Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling?
Rawlinson SC, el-Haj AJ, Minter SL, Tavares IA, Bennett A, Lanyon LE
vol. 6 (12), 1345-1351.  
01-01-1991

1990

Cellular responses to mechanical loading in vitro
EL-HAJ AJ, MINTER SL, RAWLINSON SCF, SUSWILLO RFL, LANYON LE
J Bone Miner Res vol. 5 (9), 923-932.  
01-01-1990

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconNovel antibody encapsulation and release technology for tailored Medicine and Dentistry applications
Michael Cattell, Angray Kang, Simon Rawlinson and Gleb Sukhorukov
£148,333 Barts and the London Charity
01-04-2024 - 31-03-2028

solid heart iconKTP AKT (QMUL-Lucideon) - Radio Opaque Cements and Osteoclast Testing: Traceable Bio-Remodellable Cements
Karin Hing and Simon Rawlinson
£41,283 Innovate UK
25-03-2024 - 24-07-2024
solid heart iconKTP with Lucideon: Cell testing to assist development of novel biomaterials
Karin Hing and Simon Rawlinson
£256,237 Innovate UK
17-02-2021 - 17-02-2024
bullet iconSmart drug deposition antimicrobial mouth rinses for orthodontic applications
Michael Cattell, Simon Rawlinson, Gleb Sukhorukov, David Gould and Ama Johal
£138,940 Barts and the London Charity
01-04-2020 - 31-03-2024
bullet iconDevelopment of novel bioactive glass based calcium phosphate cement
Simon Rawlinson
£17,035 Barts and the London Charity
16-05-2018 - 15-05-2019