Research

Bone, Mechanobiology, Strain, Shear

Musculoskeletal Models

Interests

Publications

Publications of specific relevance to Predictive <em>in vitro</em> Models

2024

Osseointegration of Anodized vs. Sandblasted Implant Surfaces in a Guided Bone Regeneration Acute Dehiscence‐Type Defect: An In Vivo Experimental Mandibular Minipig Model
Shahdad S, Rawlinson S, Razaghi N, Patankar A, Patel M, Roccuzzo M and Gill T
Clinical Oral Implants Research, Wiley vol. 36 (1), 127-141.  

DOI 10.1111/clr.14369

QMRO

10-10-2024

A bioactive and anti-bacterial nano-sized zirconium phosphate/GO (nZrP/GO) composite: Potential use as a coating for dental implants?
Al-Noaman A and Rawlinson SCF
Dental Materials, Elsevier 

DOI 10.1016/j.dental.2024.07.007

QMRO

08-08-2024

Primary stability and osseointegration comparing a novel tapered design tissue‐level implant with a parallel design tissue‐level implant. An experimental in vivo study
Gill T, Kühl S, Rawlinson S, Pippenger B, Bellon B and Shahdad S
Clinical Oral Implants Research, Wiley vol. 35 (9), 1114-1127.  

DOI 10.1111/clr.14301

QMRO

31-05-2024

Development of a Novel Formulation of Bioactive Glass Based Calcium Phosphate Cement for Bone Grafting
D'Onofrio A, Hill RG, Kent NW, Rawlinson SCF and Shahdad SA
Advanced Functional Materials, Wiley vol. 34 (36) 

DOI 10.1002/adfm.202401953

QMRO

08-04-2024

2023

Titanium Dioxide/Graphene Oxide Composite Coatings for 316 Stainless Steel Dental Implants.
Al-Noaman AS and Rawlinson SF
European Journal of Prosthodontics and Restorative Dentistry vol. 31 (4), 358-372.  

DOI 10.1922/ejprd_2511al-noaman15

QMRO

30-11-2023

Polyether ether ketone coated with nanohydroxyapatite/graphene oxide composite promotes bioactivity and antibacterial activity at the surface of the material
Al‐Noaman A and Rawlinson SCF
European Journal of Oral Sciences, Wiley vol. 131 (5-6) 

DOI 10.1111/eos.12946

QMRO

02-08-2023

A novel bioactive glass/graphene oxide composite coating for a polyether ether ketone‐based dental implant
Al‐Noaman A and Rawlinson SCF
European Journal of Oral Sciences, Wiley vol. 131 (2) 

DOI 10.1111/eos.12915

QMRO

27-01-2023

2021

MgF2- containing glasses as a coating for titanium dental implant. I- Glass powder
Al-Noaman A, Rawlinson SCF and Hill RG
Journal of The Mechanical Behavior of Biomedical Materials, Elsevier vol. 125 

DOI 10.1016/j.jmbbm.2021.104948

QMRO

01-11-2021

2020

Mechanobiology Journal —Welcome Editorial
Rawlinson SCF
Mechanobiology Journal, Bendola S.P.R.L - Bvba vol. 1, 1-1.  

DOI 10.32371/mbj/236079

QMRO

01-01-2020

2019

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation
Caetano-Silva SP, Novicky A, Javaheri B, Rawlinson SCF and Pitsillides AA
In Bone Research Protocols, Springer Nature 99-128.  

DOI 10.1007/978-1-4939-8997-3_6

01-01-2019

2018

Bone biology and bioactive glass in bone regeneration
Liu J, Zheng F, Rawlinson SCF, Fortune F and Kim DG
In Bone Regeneration: Concepts, Clinical Aspects and Future Directions 255-280.  
12-07-2018

Site-specific differences in osteoblast phenotype, mechanical loading response and estrogen receptor-related gene expression
Gharibi B, Ghuman MS, Cama G, Rawlinson SCF, Grigoriadis AE and Hughes FJ
Molecular and Cellular Endocrinology, Elsevier vol. 477, 140-147.  

DOI 10.1016/j.mce.2018.06.011

QMRO

19-06-2018

2017

Corrigendum: Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes.
Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE and Pitsillides AA
 

DOI 10.1002/cbf.3268

QMRO

01-06-2017

Zinc bioglasses regulate mineralization in human dental pulp stem cells.
Huang M, Hill RG and Rawlinson SCF
Dental Materials, Elsevier vol. 33 (5), 543-552.  

DOI 10.1016/j.dental.2017.03.011

QMRO

31-03-2017

Mechanical responsiveness of distinct skeletal elements – possible exploitation of low weight-bearing bone
RAWLINSON SCF
In Mechanobiology: Exploitation For Medical Benefit, Wiley Blackwell 131-142.  

DOI 10.1002/9781118966174.ch8

01-01-2017

Strain uses gap junctions to reverse stimulation of osteoblast proliferation by osteocytes
Suswillo RFL, Javaheri B, Rawlinson SCF, Dowthwaite GP, Lanyon LE and Pitsillides AA
Cell Biochemistry and Function, Wiley vol. 35 (1), 56-65.  

DOI 10.1002/cbf.3245

QMRO

01-01-2017

2016

Mechanical Responsiveness of Distinct Skeletal Elements
Rawlinson SCF
In Mechanobiology, Wiley 131-142.  

DOI 10.1002/9781118966174.ch8

23-12-2016

Mechanobiology: Exploitation for Medical Benefit
Rawlinson SCF
 

DOI 10.1002/9781118966174

07-11-2016

Preface
Rawlinson SCF
 

DOI 10.1002/9781118966174

07-11-2016

Fluoride incorporation in high phosphate containing bioactive glasses and in vitro osteogenic, angiogenic and antibacterial effects
Liu J, Rawlinson S, Hill R and FORTUNE F
Dental Materials, Elsevier vol. 32 (10), e221-e237.  

DOI 10.1016/j.dental.2016.07.003

QMRO

25-07-2016

Strontium (Sr) elicits odontogenic differentiation of human dental pulp stem cells (hDPSCs): A therapeutic role for Sr in dentine repair?
Huang M, Hill RG and Rawlinson SCF
Acta Biomaterialia, Elsevier 

DOI 10.1016/j.actbio.2016.04.037

QMRO

27-04-2016

Strontium-substituted bioactive glasses in vitro osteogenic and antibacterial effects
Liu J, Rawlinson SCF, Hill RG and Fortune F
Dental Materials, Elsevier vol. 32 (3), 412-422.  

DOI 10.1016/j.dental.2015.12.013

QMRO

08-01-2016

2015

Microscopy and supporting data for osteoblast integration within an electrospun fibrous network
Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M and Barber AH
Data in Brief, Elsevier vol. 5, 775-781.  

DOI 10.1016/j.dib.2015.10.009

QMRO

16-10-2015

3D imaging of cell interactions with electrospun PLGA nanofiber membranes for bone regeneration
Stachewicz U, Qiao T, Rawlinson SCF, Almeida FV, Li W-Q, Cattell M and Barber AH
Acta Biomaterialia, Elsevier/Science Direct vol. 27, 88-100.  

DOI 10.1016/j.actbio.2015.09.003

QMRO

05-09-2015

Nanoparticulate zinc oxide as a coating material for orthopedic and dental implants
Memarzadeh K, Sharili AS, Huang J, Rawlinson SCF and Allaker RP
Journal of Biomedical Materials Research - Part A vol. 103 (3), 981-989.  

DOI 10.1002/jbm.a.35241

01-03-2015

2014

Interactions of strontium with the dentine-pulp complex
Huang M, Rawlinson SCF and Hill RG
Dental Materials, Elsevier vol. 30, e176-e177.  

DOI 10.1016/j.dental.2014.08.354

01-01-2014

2013

Gene expression profiles of mandible reveal features of both calvarial and ulnar bones in the adult rat.
Kingsmill VJ, McKay IJ, Ryan P, Ogden MR and Rawlinson SCF
J Dent vol. 41 (3), 258-264.  

DOI 10.1016/j.jdent.2012.11.010

01-03-2013

Effect of FA addition on bioactivity of bioactive glass coating for titanium dental implant: Part II— Composite coating
Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG
Journal of Non-Crystalline Solids vol. 364, 99-106.  

DOI 10.1016/j.jnoncrysol.2012.11.046

01-03-2013

Effect of FA on bioactivity of bioactive glass coating for titanium dental implant. Part I: Composite powder
Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG
Journal of Non-Crystalline Solids vol. 364, 92-98.  

DOI 10.1016/j.jnoncrysol.2012.11.051

01-03-2013

Bioactive glass-stoichimetric wollastonite glass alloys to reduce TEC of bioactive glass coatings for dental implants
Al-Noaman A, Rawlinson SCF and Hill RG
Materials Letters vol. 94, 69-71.  

DOI 10.1016/j.matlet.2012.12.017

01-01-2013

Behaviour of osteoblast-like cells cultured on titanium coated with FA/glass composite coating
Al-Noaman A, Karpukhina N, Rawlinson SCF and Hill RG
Journal of Non-Crystalline Solids vol. 364, 85-91.  

DOI 10.1016/j.jnoncrysol.2012.12.041

01-01-2013

2012

The influence of CaF₂ content on the physical properties and apatite formation of bioactive glass coatings for dental implants
Al-Noaman A, Rawlinson SCF and Hill RG
Journal of Non-Crystalline Solids vol. 358 (15), 1850-1858.  

DOI 10.1016/j.jnoncrysol.2012.05.039

01-01-2012

The role of MgO on thermal properties, structure and bioactivity of bioactive glass coating for dental implants
Al-Noaman A, Rawlinson SCF and Hill RG
Journal of Non-Crystalline Solids vol. 358 (22), 3019-3027.  

DOI 10.1016/j.jnoncrysol.2012.07.039

01-01-2012

2011

Using Cell and Organ Culture Models to Analyze Responses of Bone Cells to Mechanical Stimulation
Pitsillides AA and Rawlinson SCF
Methods in Molecular Biology, Springer Nature vol. 816, 593-619.  

DOI 10.1007/978-1-61779-415-5_37

14-10-2011

2010

Changes in bone mineral and matrix in response to a soft diet.
Kingsmill VJ, Boyde A, Davis GR, Howell PGT and Rawlinson SCF
J Dent Res vol. 89 (5), 510-514.  

DOI 10.1177/0022034510362970

01-05-2010

2009

Adult Rat Bones Maintain Distinct Regionalized Expression of Markers Associated with Their Development
Rawlinson SCF, Mckay IJ, Ghuman M, Wellmann C, Ryan P, Prajaneh S, Zaman G, Hughes FJ and Kingsmill VJ
Plos One vol. 4 (12) 

DOI 10.1371/journal.pone.0008358

QMRO

21-12-2009

Genetic selection for fast growth generates bone architecture characterised by enhanced periosteal expansion and limited consolidation of the cortices but a diminution in the early responses to mechanical loading
Rawlinson SCF, Murray DH, Mosley JR, Wright CDP, Bredl JC, Saxon LK, Loveridge N, Leterrier C, Constantin P, Farquharson C and Pitsillides AA
Bone vol. 45 (2), 357-366.  

DOI 10.1016/j.bone.2009.04.243

01-08-2009

Ovariectomy vs. Hypofunction: Their Effects on Rat Mandibular Bone
Rawlinson SCF, Boyde A, Davis GR, Howell PGT, Hughes FJ and Kingsmill VJ
J Dent Res vol. 88 (7), 615-620.  

DOI 10.1177/0022034509340132

01-07-2009

POST-MENOPAUSAL OSTEOPOROSIS-RESISTANT SKULL BONES – GENOTYPICALLY DISTINCT FROM OSTEOPOROTIC-SUSCEPTIBLE LIMB BONE
Rawlinson SCF, McKay IJ, Ghuman M, Wellmann C, Hughes FJ and Kingsmill VJ
Maturitas, Elsevier vol. 63 

DOI 10.1016/s0378-5122(09)70152-5

01-05-2009

2008

Identifying the cellular basis for reimplantation failure in repair of the rotator cuff
Simon DWN, Clarkin CE, Das-Gupta V, Rawlinson SCF, Emery RJ and Pitsillides AA
J Bone Joint Surg Br vol. 90B (5), 680-684.  

DOI 10.1302/0301-620X.90B5.20013

01-05-2008

2005

Non-invasive axial loading of mouse tibiae increases cortical bone fori-nation and modifies trabecular organization: A new model to study cortical and cancellous compartments in a single loaded element
De Souza RL, Matsuura M, Eckstein F, Rawlinson SCF, Lanyon LE and Pitsillides AA
Bone vol. 37 (6), 810-818.  

DOI 10.1016/j.bone.2005.07.022

01-12-2005

2004

Quantitative cytochemical evidence for local increases in bone turnover at the acromial enthesis of the human coracoacromial ligament.
Chambler A, Rawlinson S, Emery R and Pitsillides A
The Journal of Rheumatology vol. 31 (11), 2216-2225.  
01-11-2004

Osteoblast-like cells from estrogen receptor alpha knockout mice have deficient responses to mechanical strain
Jessop HL, Suswillo RFL, Rawlinson SCF, Zaman G, Lee K, Das-Gupta V, Pitsillides AA and Lanyon LE
J Bone Miner Res vol. 19 (6), 938-946.  

DOI 10.1359/JBMR.

01-06-2004

2003

Methods for Analyzing Bone Cell Responses to Mechanical Loading Using In Vitro Monolayer and Organ Culture Models
Pitsillides AA, Das-Gupta V, Simon D and Rawlinson SCF
In Bone Research Protocols, Springer Nature 399-422.  

DOI 10.1385/1-59259-366-6:399

01-01-2003

Methods for analyzing bone cell responses to mechanical loading using in vitro monolayer and organ culture models
PITSILLIDES AA, DAS-GUPTA V, SIMON D and RAWLINSON SCF
In Bone Research Protocols (Methods in Molecular Medicine), Humana Press, Editors: RALSTON MHS. 399-423.  

DOI 10.1385/1-59259-366-6:399

01-01-2003

2002

Mechanical strain and fluid movement both activate extracellular regulated kinase (ERK) in osteoblast-like cells but via different signaling pathways
Jessop HL, Rawlinson SCF, Pitsillides AA and Lanyon LE
Bone vol. 31 (1), 186-194.  

DOI 10.1016/s8756-3282(02)00797-4

01-07-2002

Differing architectural designs achieve similar load-bearing resistance in genetically distinct strains of chick
Pitsillides AA, Rawlinson SCF, Wright CPD, Bredl J, Mosley JR and Lanyon LE
J Bone Miner Res vol. 17 (5), 953-953.  
01-05-2002

Human osteoblasts' proliferative responses to strain and 17 beta-estradiol are mediated by the estrogen receptor and the receptor for insulin-like growth factor I
Cheng MZ, Rawlinson SCF, Pitsillides AA, Zaman G, Mohan S, Baylink DJ and Lanyon LE
J Bone Miner Res vol. 17 (4), 593-602.  

DOI 10.1359/jbmr.2002.17.4.593

01-04-2002

2000

Arachidonic acid for loading induced prostacyclin and prostaglandin E(2) release from osteoblasts and osteocytes is derived from the activities of different forms of phospholipase A(2).
Rawlinson SC, Wheeler-Jones CP and Lanyon LE
vol. 27 (2), 241-247.  

DOI 10.1016/s8756-3282(00)00323-9

01-01-2000

1999

ROS cells proliferate in response to estrogen through IGF-I and mechanical strain through IGF-II.
Cheng MZ, Zaman G, Rawlinson SCF, Mohan S, Baylink DJ and Lanyon LE
J Bone Miner Res vol. 14 (6), 1032-1032.  
01-06-1999

Mechanical strain stimulates ROS cell proliferation through IGF-II and estrogen through IGF-I.
Cheng M, Zaman G, Rawlinson SC, Mohan S, Baylink DJ and Lanyon LE
vol. 14 (10), 1742-1750.  

DOI 10.1359/jbmr.1999.14.10.1742

01-01-1999

Bone's early responses to mechanical loading differ in distinct genetic strains of chick: selection for enhanced growth reduces skeletal adaptability.
Pitsillides AA, Rawlinson SC, Mosley JR and Lanyon LE
vol. 14 (6), 980-987.  

DOI 10.1359/jbmr.1999.14.6.980

01-01-1999

Mechanical strain stimulates nitric oxide production by rapid activation of endothelial nitric oxide synthase in osteocytes.
Zaman G, Pitsillides AA, Rawlinson SC, Suswillo RF, Mosley JR, Cheng MZ, Platts LA, Hukkanen M, Polak JM and Lanyon LE
vol. 14 (7), 1123-1131.  

DOI 10.1359/jbmr.1999.14.7.1123

01-01-1999

1998

Heme oxygenase isozymes in bone: induction of HO-1 mRNA following physiological levels of mechanical loading in vivo.
Rawlinson SC, Zaman G, Mosley JR, Pitsillides AA and Lanyon LE
vol. 23 (5), 433-436.  

DOI 10.1016/s8756-3282(98)00125-2

01-01-1998

1997

Effect of exogenous carbon monoxide on loading-related pre-osteogenic responses
Rawlinson SCF, Pitsillides AA, Zaman G and Lanyon LE
J Bone Miner Res vol. 12 (9), P13-P13.  
01-09-1997

Enhancement by sex hormones of the osteoregulatory effects of mechanical loading and prostaglandins in explants of rat ulnae.
Cheng MZ, Zaman G, Rawlinson SC, Pitsillides AA, Suswillo RF and Lanyon LE
vol. 12 (9), 1424-1430.  

DOI 10.1359/jbmr.1997.12.9.1424

01-01-1997

A putative role for osteocyte eNOS-derived NO in adaptive bone remodelling
Hukkanen M, Pitsillides AA, Rawlinson SCF, Suswillo R, Zaman G, Platts LAM, Polak JM and Lanyon LE
J Pathol vol. 181, A42-A42.  
01-01-1997

1996

A putative role for osteocyte eNOS-derived NO in adaptive bone (re)modelling: An extension to an endothelial paradigm
Pitsillides AA, Rawlinson SCF, Suswillo R, Zaman G, Hukkanen M, Platts L, Polak JM and Lanyon LE
International Journal of Experimental Pathology vol. 77 (6) 
01-12-1996

P10. Early responses to mechanical load in selectively-bred embryonic chicks differ
Pitsillides AA, Rawlinson SCF and Lanyon LE
Bone, Elsevier vol. 19 (6) 

DOI 10.1016/s8756-3282(97)84322-0

01-12-1996

A possible role for carbon monoxide in the adaptive response of bone cells to dynamic mechanical loading
Rawlinson SCF, Zaman G, Pitsillides AA and Lanyon LE
J Bone Miner Res vol. 11 (11), P8-P8.  
01-11-1996

Mechanical loading and sex hormone interactions in organ cultures of rat ulna.
Cheng MZ, Zaman G, Rawlinson SC, Suswillo RF and Lanyon LE
vol. 11 (4), 502-511.  

DOI 10.1002/jbmr.5650110411

01-01-1996

Involvement of different ion channels in osteoblasts' and osteocytes' early responses to mechanical strain.
Rawlinson SC, Pitsillides AA and Lanyon LE
vol. 19 (6), 609-614.  

DOI 10.1016/s8756-3282(96)00260-8

01-01-1996

1995

Strain measurement by bone cells during mechanical loading
Rawlinson SCF, Pitsillides AA and Lanyon LE
Bone, Elsevier vol. 17 (3) 

DOI 10.1016/8756-3282(95)97349-k

01-09-1995

MECHANICAL STRAIN-INDUCED NITRIC-OXIDE PRODUCTION BY OSTEOBLASTS AND OSTEOCYTES
PITSILLIDES AA, RAWLINSON SCF, SUSWILLO RFL, ZAMAN G, NIJWEIDE PI and LANYON LE
J Bone Miner Res vol. 10, S217-S217.  
01-08-1995

MECHANODEPENDENT SIGNALING PATHWAYS IN OSTEOCYTES AND OSTEOBLASTS
RAWLINSON SCF, PITSILLIDES AA and LANYON LE
J Bone Miner Res vol. 10, S342-S342.  
01-08-1995

MECHANICAL LOADING, PROSTAGLANDIN AND SEX-HORMONE INTERACTIONS IN MALE AND FEMALE RAT ULNAE IN CULTURE
CHENG MZ, ZAMAN G, RAWLINSON SCF, SUSWILLO RFL and LANYON LE
J Bone Miner Res vol. 10, S342-S342.  
01-08-1995

Mechanical strain-induced NO production by bone cells: a possible role in adaptive bone (re)modeling?
Pitsillides AA, Rawlinson SC, Suswillo RF, Bourrin S, Zaman G and Lanyon LE
vol. 9 (15), 1614-1622.  

DOI 10.1096/fasebj.9.15.8529841

01-01-1995

Calvarial and limb bone cells in organ and monolayer culture do not show the same early responses to dynamic mechanical strain.
Rawlinson SC, Mosley JR, Suswillo RF, Pitsillides AA and Lanyon LE
vol. 10 (8), 1225-1232.  

DOI 10.1002/jbmr.5650100813

01-01-1995

1993

Exogenous prostacyclin, but not prostaglandin E2, produces similar responses in both G6PD activity and RNA production as mechanical loading, and increases IGF-II release, in adult cancellous bone in culture.
Rawlinson SC, Mohan S, Baylink DJ and Lanyon LE
vol. 53 (5), 324-329.  

DOI 10.1007/BF01351837

01-01-1993

1992

LOAD-RELATED OSTEOGENESIS, PROSTACYCLIN AND IGF-II
RAWLINSON SCF, MOHAN S, BAYLINK DJ and LANYON LE
J Bone Miner Res vol. 7, S141-S141.  
01-08-1992

1991

Loading-related increases in prostaglandin production in cores of adult canine cancellous bone in vitro: a role for prostacyclin in adaptive bone remodeling?
Rawlinson SC, el-Haj AJ, Minter SL, Tavares IA, Bennett A and Lanyon LE
vol. 6 (12), 1345-1351.  

DOI 10.1002/jbmr.5650061212

01-01-1991

1990

Cellular responses to mechanical loading in vitro
EL-HAJ AJ, MINTER SL, RAWLINSON SCF, SUSWILLO RFL and LANYON LE
J Bone Miner Res vol. 5 (9), 923-932.  

DOI 10.1002/jbmr.5650050905

01-01-1990

Grants

Grants of specific relevance to Predictive in vitro Models

Novel antibody encapsulation and release technology for tailored Medicine and Dentistry applications
Michael Cattell, Angray Kang, Simon Rawlinson and Gleb Sukhorukov
£148,333 Barts and the London Charity
01-04-2024 - 31-03-2028

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KTP AKT (QMUL-Lucideon) - Radio Opaque Cements and Osteoclast Testing: Traceable Bio-Remodellable Cements
Karin Hing and Simon Rawlinson
£41,283 Innovate UK
25-03-2024 - 24-07-2024

KTP with Lucideon: Cell testing to assist development of novel biomaterials
Karin Hing and Simon Rawlinson
£256,237 Innovate UK
17-02-2021 - 17-02-2024

Smart drug deposition antimicrobial mouth rinses for orthodontic applications
Michael Cattell, Simon Rawlinson, Gleb Sukhorukov, David Gould and Ama Johal
£138,940 Barts and the London Charity
01-04-2020 - 31-03-2024

Development of novel bioactive glass based calcium phosphate cement
Simon Rawlinson
£17,035 Barts and the London Charity
16-05-2018 - 15-05-2019