Prof Steffi Krause
Professor of Electroanalytical Systems
School of Engineering and Materials Science
Queen Mary University of London
Queen Mary University of London
Research
electrochemistry, photoelectrochemical imaging, functional cell imaging, biosensors
Interests
Our group has developed a photoelectrochemical imaging system for functional imaging of cellular processes in real time and with subcellular resolution. Our measurement technology has been shown to be sensitive to the surface charges and the permeability of cell membranes of cells in culture and is also capable of monitoring the concentrations of ions released by cells.Publications
2025
Zinc ion sensitive light-addressable potentiometric sensors based on organic self-assembled monolayers on silicon on sapphireZhong M, Fang L, Zhou B, Watkinson M, Krause S
Sensors and Actuators B Chemical, Elsevier vol. 443
01-11-2025
2024
Actively Driven Light-Addressable Sensor/Actuator System for Automated pH Control for the Integration in Lab-On-A-Chip (LoC) PlatformsWelden R, Das A, Krause S, Schöning MJ, Wagner PH, Wagner T
Acs Sensors, American Chemical Society (Acs) vol. 9 (3), 1533-1544.
06-03-2024
2023
Numerical investigation of a graphene-on-semiconductor device for optical monitoring of cell electrophysiologyGorecki J, Krause S
Iscience, Elsevier vol. 27 (1)
24-11-2023
2022
Photoelectrochemical imaging of single cardiomyocytes and monitoring of their action potentials through contact force manipulation of organoidsJacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T, Krause S
Biosensors and Bioelectronics, Elsevier
21-12-2022
Photoelectrochemical Detection of Calcium Ions Based on Hematite Nanorod SensorsZhou B, Jiang Y, Guo Q, Das A, Jorge Sobrido A, Hing K, Zayats A, Krause S
Acs Applied Nano Materials, American Chemical Society
10-11-2022
Light-Addressable Electrochemical Sensors toward Spatially Resolved Biosensing and Imaging ApplicationsMeng Y, Chen F, Wu C, Krause S, Wang J, Zhang DW
Acs Sensors, American Chemical Society
28-06-2022
Hematite Nanorods as a Platform for Photoelectrochemical Imaging and SensingKrause S, Zhou B, Jiang Y, Guo Q, Das A, Sobrido AJ, Hing KA, Zayats AV
In Ssrn Electronic Journal
01-01-2022
2021
Self-powered ultrasensitive and highly stretchable temperature–strain sensing composite yarnsWan K, Liu Y, Santagiuliana G, Barandun G, Taroni Junior P, Güder F, Bastiaansen CWM, Baxendale M et al.
Materials Horizons
12-07-2021
Photoelectrochemical imaging system with high spatiotemporal resolution for visualizing dynamic cellular responsesZhou B, Das A, Zhong M, Guo Q, Zhang D-W, Hing KA, Sobrido AJ, Titirici M-M et al.
Biosensors and Bioelectronics, Elsevier vol. 180
02-03-2021
2020
Ammonia Gas Sensor Response of a Vertical Zinc Oxide Nanorod-Gold Junction Diode at Room TemperatureTu Y, Kyle C, Luo H, Zhang DW, Das A, Briscoe J, Dunn S, Titirici MM et al.
Acs Sensors vol. 5 (11), 3568-3575.
25-11-2020
2019
InGaN as a substrate for AC photoelectrochemical imagingZhou B, Das A, Kappers M, Oliver R, Humphreys C, Krause S
Sensors, Mdpi
11-10-2019
Modulated light-activated electrochemistry at silicon functionalized with metal-organic frameworks towards addressable DNA chips.Wang J, Yang Z, Chen W, Du L, Jiao B, Krause S, Wang P, Wei Q et al.
Biosensors and Bioelectronics, Elsevier vol. 146, 111750-111750.
03-10-2019
Flexible and Stretchable Self‐Powered Multi‐Sensors Based on the N‐Type Thermoelectric Response of Polyurethane/Na
x
(Ni‐ett)
n
CompositesWan K, Taroni PJ, Liu Z, Liu Y, Tu Y, Santagiuliana G, Hsia I, Zhang H et al.
Advanced Electronic Materials, Wiley, 1900582-1900582.
15-09-2019
Peptide Cross-Linked Poly(2-oxazoline) as a Sensor Material for the Detection of Proteases with a Quartz Crystal Microbalance.Ahmad N, Colak B, Gibbs MJ, Zhang D-W, Gautrot JE, Watkinson M, Becer CR, Krause S
Biomacromolecules vol. 20 (7), 2506-2514.
07-06-2019
Photoelectrochemical Imaging System for the Mapping of Cell Surface Charges.Wu F, Zhou B, Wang J, Zhong M, Das A, Watkinson M, Hing K, Zhang D-W et al.
Anal Chem
15-04-2019
Peptide Cross-Linked Poly (Ethylene Glycol) Hydrogel Films as Biosensor Coatings for the Detection of CollagenaseAhmad N, Colak B, Zhang D-W, Gibbs MJ, Watkinson M, Becer CR, Gautrot JE, Krause S
Sensors, Mdpi vol. 19 (7)
08-04-2019
2018
Photoelectrochemical Imaging Using Carbon Dots (CDs) Derived from ChitosanZhang D, Papaioannou N, Titirici M-M, Krause S
Proceedings, Mdpi vol. 2 (13)
10-12-2018
Collagenase Biosensor Based on the Degradation of Peptide Cross-Linked Poly(Ethylene Glycol) Hydrogel FilmsAhmad N, Colak B, Gibbs MJ, Zhang D-W, Becer CR, Watkinson M, Gautrot JE, Krause S
, Mdpi vol. 2 (13)
30-11-2018
The Effect of Semiconductor Morphology on the Spatial Resolution of ZnO Based Light-Addressable Potentiometric SensorsTu Y, Li J, Zhang D-W, Briscoe J, Krause S
EUROSENSORS 2018.
27-11-2018
Light-Addressable Potentiometric Sensors using ZnO Nanorods as the Sensor Substrate for Bioanalytical ApplicationsTU Y, AHMAD N, BRISCOE J, ZHANG D, KRAUSE S
Analytical Chemistry, American Chemical Society
22-06-2018
Surface modification and construction of LAPS towards biosensing applicationsWang J, Du L, Krause S, Wu C, Wang P
Sensors and Actuators, B: Chemical vol. 265, 161-173.
08-03-2018
Photoelectrochemical response of carbon dots (CDs) derived from chitosan and their use in electrochemical imagingZHANG D, PAPAIOANNOU N, David NM, LUO H, GAO H, Tanase LC, Degousee T, Samori P et al.
Materials Horizons, Rsc
12-02-2018
Control of oxygen vacancies in ZnO nanorods by annealing and their influence on ZnO/PEDOT:PSS diode behaviourTU Y, CHEN S, LI X, GORBACIOVA J, GILLIN WP, KRAUSE S, BRISCOE J
Journal of Materials Chemistry C, Royal Society of Chemistry
02-02-2018
Light-Addressable Potentiometric Sensors for (Bio-)chemical Sensing and ImagingSchöning MJ, Wagner T, Poghossian A, Miyamoto K-I, Werner CF, Krause S, Yoshinobu T
In Encyclopedia of Interfacial Chemistry, Elsevier 295-308.
01-01-2018
(Bio-)chemical Sensing and Imaging by LAPS and SPIMYoshinobu T, Krause S, Miyamoto K-I, Werner CF, Poghossian A, Wagner T, Schöning MJ
In Label-Free Biosensing, Springer Nature 103-132.
01-01-2018
2017
LAPS and SPIM imaging using ITO coated glass as the substrate materialZhang D, Wu F, KRAUSE SK
Analytical Chemistry, American Chemical Society
05-07-2017
Biological imaging using light-addressable potentiometric sensors and scanning photo-induced impedance microscopyWu F, Campos I, Zhang D, KRAUSE SK
Proceedings of The Royal Society a: Mathematical, Physical and Engineering Sciences, Royal Society, The
03-05-2017
Image Detection of Yeast Saccharomyces Cerevisiae By Light-Addressable Potentiometric Sensors (LAPS)Zhang D, Krause S
Ecs Meeting Abstracts, The Electrochemical Society vol. MA2017-01 (38), 1770-1770.
15-04-2017
Electrochemical Imaging of Copper Contamination on Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a ‘Click’ Reaction with Light-Addressable Potentiometric Sensors and Scanning Photo-Induced Impedance MicroscopyWu F, Watkinson M, Krause S
Ecs Meeting Abstracts, The Electrochemical Society vol. MA2017-01 (38), 1769-1769.
15-04-2017
Copper Contamination of Self-Assembled Organic Monolayer Modified Silicon Surfaces Following a “Click” Reaction Characterized with LAPS and SPIMWu F, Zhang DW, Wang J, Watkinson M, Krause S
Langmuir vol. 33 (13), 3170-3177.
04-04-2017
High-resolution impedance and potential imaging using light-addressable potentiometric sensors for bio-imaging applicationsKrause S
, 222-222.
01-03-2017
2016
Image detection of yeast Saccharomyces cerevisiae by light-addressable potentiometric sensors (LAPS)Zhang DW, Wu F, Wang J, Watkinson M, KRAUSE SK
Electrochemistry Communications vol. 72, 41-45.
24-08-2016
The effect of gold nanoparticles on the impedance of microcapsules visualized by scanning photo-induced impedance microscopyWang J, Campos I, Wu F, Zhu J, Sukhorukov GB, Palma M, Watkinson M, Krause S
Electrochimica Acta vol. 208, 39-46.
04-05-2016
2015
click Patterning of Self-Assembled Monolayers on Hydrogen-Terminated Silicon Surfaces and Their Characterization Using Light-Addressable Potentiometric SensorsWang J, Wu F, Watkinson M, Zhu J, Krause S
Langmuir vol. 31 (35), 9646-9654.
08-09-2015
α-Amylase sensor based on the degradation of oligosaccharide hydrogel films monitored with a quartz crystal sensor.Gibbs MJ, Biela A, Krause S
Biosens Bioelectron vol. 67, 540-545.
15-05-2015
Incorporation of Ag nanowires in CuWO4 for improved visible light-induced photoanode performanceZhang H, Yilmaz P, Ansari JO, Khan FF, Binions R, Krause S, Dunn S
Journal of Materials Chemistry A vol. 3 (18), 9638-9644.
26-03-2015
Disposable MMP-9 sensor based on the degradation of peptide cross-linked hydrogel films using electrochemical impedance spectroscopyBiela A, Watkinson M, Meier UC, Baker D, Giovannoni G, Becer CR, Krause S
Biosensors and Bioelectronics vol. 68, 660-667.
27-01-2015
2014
High-sensitivity light-addressable potentiometric sensors using silicon on sapphire functionalized with self-assembled organic monolayersWang J, Zhou Y, Watkinson M, Gautrot J, Krause S
Sensors and Actuators B: Chemical, Elsevier vol. 209, 230-236.
26-11-2014
2013
Degradation behaviour of thin polymer films of poly (amide ester) hydrogel using quartz crystal microbalanceDzaraini K, Norizan A, Krause S, Hunter C, Milanesi L
Advanced Materials Research vol. 812, 38-45.
29-10-2013
2012
A label-free aptasensor for the sensitive and specific detection of cocaine using supramolecular aptamer fragments/target complex by electrochemical impedance spectroscopyZhang DW, Zhang FT, Cui YR, Deng QP, Krause S, Zhou YL, Zhang XX
Talanta vol. 92, 65-71.
15-04-2012
2011
Generic protease detection technology for monitoring periodontal diseaseZheng X, Cook JP, Watkinson M, Yang S, Douglas I, Rawlinson A, Krause S
Faraday Discussions vol. 149, 37-47.
17-01-2011
2010
High resolution LAPS and SPIMChen L, Zhou Y, Jiang S, Kunze J, Schmuki P, Krause S
Electrochemistry Communications vol. 12 (6), 758-760.
01-06-2010
2009
A peptide cross-linked polyacrylamide hydrogel for the detection of human neutrophil elastaseKamarun D, Zheng XW, Milanesi L, Hunter CA, Krause S
Electrochimica Acta vol. 54 (22), 4985-4990.
01-09-2009
Sensor materials for the detection of proteasesStair JL, Watkinson M, Krause S
Biosensors and Bioelectronics vol. 24 (7), 2113-2118.
15-03-2009
Selected Papers from the Second International Conference on Optical, Optoelectronic and Photonic Materials and Applications, 2007Sweeney SJ, Krause S
J Mater Sci-Mater El vol. 20, 1-2.
01-01-2009
Editorial: Selected papers from the second international conference on optical, optoelectronic and photonic materials and applications, 2007Sweeney SJ, Krause S
Journal of Materials Science Materials in Electronics vol. 20 (SUPPL. 1), S1-S2.
01-01-2009
2008
Repair of thin thermally grown silicon dioxide by anodic oxidationChen L, Zhou Y, Krause S, Munoz AG, Kunze J, Schmuki P
Electrochimica Acta vol. 53 (8), 3395-3402.
10-03-2008
2007
Biosensor arrays based on the degradation of thin polymer films interrogated by scanning photoinduced impedance microscopy.Zhou Y, Jiang S, Krause S, Chazalviel J-N
Anal Chem vol. 79 (23), 8974-8978.
01-12-2007
Scanning photoinduced impedance microscopy using amorphous silicon photodiode structures.Zhou Y, Chen L, Krause S, Chazalviel J-N
Anal Chem vol. 79 (16), 6208-6214.
15-08-2007
2006
Scanning Photo-Induced Impedance Microscopy - Resolution studies and polymer characterizationKrause S, Moritz W, Talabani H, Xu M, Sabot A, Ensell G
Electrochimica Acta vol. 51 (8-9), 1423-1430.
20-01-2006
Biosensor arrays based on the degradation of thin polymer films interrogated by Scanning Photo-induced Impedance MicroscopyZhou YL, Krause S, Chazalviel JN, McNeil CJ
01-01-2006
Sensors based on thin film degradationKRAUSE SK, Fernandez-Sanchez C, McNeil CJ
In Encyclopedia of Sensors, American Scientific Publishers 289-306.
01-01-2006
2004
High resolution LAPS using amorphous silicon as the semiconductor materialMoritz W, Yoshinobu T, Finger F, Krause S, Martin-Fernandez M, Schoning MJ
Sensors and Actuators B-Chemical vol. 103 (1-2), 436-441.
29-09-2004
2003
Impedance methodsKRAUSE SK
In Encyclopedia of Electrochemistry, Volume 3, Instrumentation and Electroanalytical Chemistry, Wiley-Vch Verlag 196-229.
01-01-2003
2002
Simultaneous quartz crystal microbalance impedance and electrochemical impedance measurements. Investigation into the degradation of thin polymer films.Sabot A, Krause S
Anal Chem vol. 74 (14), 3304-3311.
15-07-2002
Scanning photo-induced impedance microscopy - an impedance based imaging techniqueKrause S, Talabani H, Xu M, Moritz W, Griffiths J
Electrochimica Acta vol. 47 (13-14), 2143-2148.
25-05-2002
2001
Biosensor based on enzyme-catalysed degradation of thin polymer filmsSumner C, Krause S, Sabot A, Turner K, McNeil CJ
Biosensors & Bioelectronics vol. 16 (9-12), 709-714.
01-12-2001
Re-activation of an all solid state oxygen sensorMoritz W, Krause S, Roth U, Klimm D, Lippitz A
Anal Chim Acta vol. 437 (2), 183-190.
27-06-2001
Combined QCM and electrochemical impedance measurements for biosensor applications.KRAUSE SK, Sabot A, Sumner C
Chemical and Biological Sensors and Analytical Methods II, ECS Conference, San Francisco.
01-01-2001
The detection of organic pollutants in water with calixarene coated electrodesWilkop T, Krause S, Nabok A, Ray AK, Yates R, Moebius D, Miller R
01-01-2001
2000
A transducer based on enzyme-induced degradation of thin polymer films monitored by surface plasmon resonance.Sumner C, Sabot A, Turner K, Krause S
Anal Chem vol. 72 (21), 5225-5232.
01-11-2000
Photocurrent measurements for laterally resolved interface characterizationMoritz W, Gerhardt I, Roden D, Xu M, Krause S
Fresenius Journal of Analytical Chemistry vol. 367 (4), 329-333.
01-06-2000
1999
Electrochemical sensor for measurement of urea and creatinine in serum based on ac impedance measurement of enzyme-catalyzed polymer transformationHo WO, Krause S, McNeil CJ, Pritchard JA, Armstrong RD, Athey D, Rawson K
Anal Chem vol. 71 (10), 1940-1946.
15-05-1999
1998
Silicon-Based Sensor for Flourine GasMoritz W, Krause S, Bartholomäus L, Gabusjan T, Vasiliev AA, Godovski DY, Malyshev VV
Acs Symposium Series vol. 690, 119-129.
01-01-1998
1995
Electrochemical Sensors Based on Impedance Measurement of Enzyme-Catalyzed Polymer Dissolution: Theory and ApplicationsMcNeil CJ, Athey D, Ball M, Ho WO, Krause S, Armstrong RD, Des Wright J, Rawson K
Analytical Chemistry, American Chemical Society (Acs) vol. 67 (21), 3928-3935.
01-11-1995
Monitoring of HF and F2 using a field-effect sensorMoritz W, Krause S, Vasiliev AA, Godovski DY, Malyshev VV
Sensors and Actuators B Chemical, Elsevier vol. 24 (1-3), 194-196.
01-03-1995
1994
Improved long-term stability for an LaF3 based oxygen sensorKrause S, Moritz W, Grohmann I
Sensors and Actuators B Chemical, Elsevier vol. 18 (1-3), 148-154.
01-03-1994
1992
A low-temperature oxygen sensor based on the Si/LaF3/Pt capacitive structureKrause S, Moritz W, Grohmann I
Sensors and Actuators B Chemical, Elsevier vol. 9 (3), 191-196.
01-10-1992
1991
Chemical sensitivity of an ISFET with Ta2O5 membrane in strong acid and alkaline solutionsBobrov PV, Tarantov YA, Krause S, Moritz W
Sensors and Actuators B Chemical, Elsevier vol. 3 (1), 75-81.
01-01-1991
Solid state chemical sensors using LaF3 thin layer structuresKRAUSE S, Moritz W
In Recent Research Development Solid State Ionics, Transworld Research Network
Photoelectrochemical detection of calcium ions based on hematite nanorod sensor substratesZhou B, Jiang Y, Guo Q, Das A, Sobrido A, Hing K, Zayats A, Krause S
In Chemrxiv
Photoelectrochemical imaging of action potentials for single cardiomyocytes through contact force manipulation of organoidsJacques R, Zhou B, Marhuenda E, Gorecki J, Das A, Iskratsch T, Krause S
In Biorxiv
Grants
3D Photoelectrochemical Imaging in Porous Light-Addressable StructuresSteffi Krause, Joseph Briscoe and Thomas Iskratsch
£202,248 Engineering and Physical Sciences Research Council
01-02-2021 - 30-04-2023
Materials development for carbon dioxide gas sensorsSteffi Krause and Joseph Briscoe
£5,500 McGowan Sensor Labs Limited
10-09-2018 - 31-07-2019
Overseas Conference Travel Grant - Analytical Chemistry Trust FundSteffi Krause
£600 Analytical Chemistry Trust Fund
09-09-2018 - 12-09-2018
Combined LAPS and SICM for multimodal live cell imagingSteffi Krause
£504,481 EPSRC Engineering and Physical Sciences Research Council
01-06-2018 - 28-02-2023
ZINCLAPS - Light-addressable potentiometric sensors (LAPS) for zinc imaging with high spatiotemporal resolution for elucidating the role of zinc in age related macular degenerationSteffi Krause
£156,364 EU Commission - Horizon 2020
25-08-2017 - 24-08-2019