Dr Neil Dufton

Lecturer in Inflammatory Sciences

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The William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London

n.dufton@qmul.ac.uk

I am interested in developing an in vitro platform to understand the dynamic changes that occur during endothelial-to-mesenchymal transition (EndMT) and its role in regulating the tissue micro-environment. EndMT, which plays a central role in driving vascular dysfunction, is involved in the pathogenesis of numerous chronic diseases including liver fibrosis, atherosclerosis and rheumatoid arthritis. I would like develop an imaging platform that will allow me understand key stages of endothelial transition and the plasticity of the mesenchymal-derived cells to determine if EndMT can be used as a therapeutic target to reverse vascular dysfunction.