Dr Neil Dufton
Lecturer in Inflammatory Sciences
School of Medicine & Dentistry, Queen Mary University of London
I am interested in developing an in vitro platform to understand the dynamic changes that occur during endothelial-to-mesenchymal transition (EndMT) and its role in regulating the tissue micro-environment. EndMT, which plays a central role in driving vascular dysfunction, is involved in the pathogenesis of numerous chronic diseases including liver fibrosis, atherosclerosis and rheumatoid arthritis. I would like develop an imaging platform that will allow me understand key stages of endothelial transition and the plasticity of the mesenchymal-derived cells to determine if EndMT can be used as a therapeutic target to reverse vascular dysfunction.