Dr Manikandan Subramanian
Senior Lecturer
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Vascular biology, Inflammation, Intercellular communication
Publications
2025
TRIB3 Links Endoplasmic Reticulum Stress to Impaired Efferocytosis in Atherosclerosis.Singhal A, Russo S, Dhawan UK, Bhutia K, Bell CG, Hayat H, Nightingale TD, de Gaetano M et al.
Circulation Research, Wolters Kluwer
04-11-2025
Macrophage DNases Limit Neutrophil Extracellular Trap–Mediated Defective Efferocytosis in AtherosclerosisDhawan UK, Vartak T, Englert H, Russo S, Vasconcellos LRC, Singhal A, Chakraborty R, Bhagat KK et al.
Circulation Research, Wolters Kluwer vol. 137 (10), 1255-1275.
01-10-2025
Neutrophil Extracellular Traps (NETs) as drivers of atherosclerosis: Pathogenic mechanisms and therapeutic opportunitiesShetty S, Subramanian M
Pharmacology & Therapeutics, Elsevier vol. 274
20-08-2025
Macrophage-secreted dnase prevents neutrophil extracellular trap mediated impairment of efferocytosis in atherosclerosisDhawan U, Singhal A, Englert H, Vartak T, Sukka S, Tabas I, Brennan E, Godson C et al.
Atherosclerosis, Elsevier vol. 407
01-08-2025
2024
Lipid-induced ATF4 signalling impairs macrophage efferocytosis and promotes atherosclerotic plaque necrosisSinghal A, Dhawan U, Bhutia K, Wilson H, Velasco G, Kiss-Toth E, Subramanian M
Atherosclerosis, Elsevier vol. 395
01-08-2024
2023
Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signalingBhattacharya P, Dhawan UK, Hussain MT, Singh P, Bhagat KK, Singhal A, Austin-Williams S, Sengupta S et al.
Cell Reports, Elsevier vol. 42 (7)
01-07-2023
2022
Resolution pharmacology − A fresh approach to the clinical management of human inflammatory diseasesPerretti M, Subramanian M
Seminars in Immunology, Elsevier vol. 65
22-12-2022
Hypercholesterolemia promotes autoantibody production and a lupus‐like pathology via decreased DNase‐mediated clearance of DNADhawan UK, Margraf A, Lech M, Subramanian M
Journal of Cellular and Molecular Medicine, Wiley vol. 26 (20), 5267-5276.
13-09-2022
Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond?Bhattacharya P, Kanagasooriyan R, Subramanian M
Current Opinion in Pharmacology, Elsevier vol. 66
28-08-2022
Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe -/- MiceManickam V, Dhawan UK, Singh D, Gupta M, Subramanian M
Frontiers in Pharmacology, Frontiers vol. 13
01-06-2022
2021
Hypercholesterolemia Impairs Clearance of Neutrophil Extracellular Traps and Promotes Inflammation and Atherosclerotic Plaque Progression.Dhawan UK, Bhattacharya P, Narayanan S, Manickam V, Aggarwal A, Subramanian M
Arteriosclerosis, Thrombosis and Vascular Biology, American Heart Association, ATVBAHA1203-ATVBAHA1203.
05-08-2021
CD36 pumps fat to defang killer T cells in tumorsSubramanian M, Marelli-Berg FM
Cell Metabolism, Elsevier vol. 33 (8), 1509-1511.
01-08-2021
Dead cell and debris clearance in the atherosclerotic plaque: Mechanisms and therapeutic opportunities to promote inflammation resolutionDhawan UK, Singhal A, Subramanian M
Pharmacological Research, Elsevier vol. 170
02-06-2021
Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2Naushin S, Sardana V, Ujjainiya R, Bhatheja N, Kutum R, Bhaskar AK, Pradhan S, Prakash S et al.
Elife, Elife vol. 10
20-04-2021
Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarctionDeBerge M, Glinton K, Subramanian M, Wilsbacher LD, Rothlin CV, Tabas I, Thorp EB
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 131 (6)
15-03-2021
2020
Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of InjuryYurdagul A, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC et al.
Cell Metabolism, Elsevier vol. 31 (3), 518-533.e10.
30-01-2020
2018
Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation ResolutionProto JD, Doran AC, Gusarova G, Yurdagul A, Sozen E, Subramanian M, Islam MN, Rymond CC et al.
Immunity, Elsevier vol. 49 (4), 666-677.e6.
01-10-2018
Hypercholesterolemia induces T cell expansion in humanized immune miceProto JD, Doran AC, Subramanian M, Wang H, Zhang M, Sozen E, Rymond CC, Kuriakose G et al.
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 128 (6), 2370-2375.
30-04-2018
2017
Colony stimulating factors (CSFs): Complex roles in atherosclerosisSinghal A, Subramanian M
Cytokine, Elsevier vol. 122
01-11-2017
Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by MacrophagesWang Y, Subramanian M, Yurdagul A, Barbosa-Lorenzi VC, Cai B, de Juan-Sanz J, Ryan TA, Nomura M et al.
Cell, Elsevier vol. 171 (2), 331-345.e22.
21-09-2017
2016
Deficiency of AXL in Bone Marrow-Derived Cells Does Not Affect Advanced Atherosclerotic Lesion ProgressionSubramanian M, Proto JD, Matsushima GK, Tabas I
Scientific Reports, Springer Nature vol. 6 (1)
13-12-2016
MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammationCai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin C-S, Spite M, Fredman G et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 113 (23), 6526-6531.
19-05-2016
Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced AtherosclerosisKamaly N, Fredman G, Fojas JJR, Subramanian M, Choi WI, Zepeda K, Vilos C, Yu M et al.
Acs Nano, American Chemical Society (Acs) vol. 10 (5), 5280-5292.
28-04-2016
Expansion of Regulatory T Cells Promotes the Clearance of Apoptotic Cells by Macrophages in Murine Atherosclerotic PlaquesProto JD, Sozen E, Subramanian M, Tabas I
The Faseb Journal, Wiley vol. 30 (S1)
01-04-2016
2015
Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in ObesitySubramanian M, Ozcan L, Ghorpade DS, Ferrante AW, Tabas I
Plos One, Public Library of Science (Plos) vol. 10 (8)
28-08-2015
A Potential Role for Regulatory T Cells in Apoptotic Cell Clearance by Macrophages in a Murine Model of Acute Lung InjuryProto J, Subramanian M, Islam M, Hook J, Gusarova G, Bhattacharya J, Tabas I
The Faseb Journal, Wiley vol. 29 (S1)
01-04-2015
Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling.Subramanian M, Thorp E, Tabas I
Circ Res vol. 116 (2), e13-e24.
16-01-2015
Nitric oxide is the key mediator of death induced by fisetin in human acute monocytic leukemia cells.Ash D, Subramanian M, Surolia A, Shaha C
American Journal of Cancer Research vol. 5 (2), 481-497.
15-01-2015
2014
Interleukin-3/Granulocyte Macrophage Colony–Stimulating Factor Receptor Promotes Stem Cell Expansion, Monocytosis, and Atheroma Macrophage Burden in Mice With Hematopoietic ApoE DeficiencyWang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I et al.
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 34 (5), 976-984.
20-03-2014
A new RIDDle in DC-mediated cross-presentationSubramanian M, Tabas I
Nature Immunology, Springer Nature vol. 15 (3), 213-215.
18-02-2014
An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivoSubramanian M, Hayes CD, Thome JJ, Thorp E, Matsushima GK, Herz J, Farber DL, Liu K et al.
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 124 (3), 1296-1308.
10-02-2014
Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunityWestphalen K, Gusarova GA, Islam MN, Subramanian M, Cohen TS, Prince AS, Bhattacharya J
Nature, Springer Nature vol. 506 (7489), 503-506.
19-01-2014
2013
Dendritic cells in atherosclerosisSubramanian M, Tabas I
Seminars in Immunopathology, Springer Nature vol. 36 (1), 93-102.
06-11-2013
Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticlesKamaly N, Fredman G, Subramanian M, Gadde S, Pesic A, Cheung L, Fayad ZA, Langer R et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 110 (16), 6506-6511.
26-03-2013
2012
Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCsSubramanian M, Thorp E, Hansson GK, Tabas I
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 123 (1), 179-188.
21-12-2012
Macrophage Autophagy Plays a Protective Role in Advanced AtherosclerosisLiao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J et al.
Cell Metabolism, Elsevier vol. 15 (4), 545-553.
22-03-2012
2011
The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosisThorp E, Subramanian M, Tabas I
European Journal of Immunology, Wiley vol. 41 (9), 2515-2518.
26-08-2011
Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK)Thorp E, Vaisar T, Subramanian M, Mautner L, Blobel C, Tabas I
Journal of Biological Chemistry, Elsevier vol. 286 (38), 33335-33344.
02-08-2011
2009
Oestrogen modulates human macrophage apoptosis via differential signalling through oestrogen receptor‐α and βSubramanian M, Shaha C
Journal of Cellular and Molecular Medicine, Wiley vol. 13 (8b), 2317-2329.
02-08-2009
Oestrogen modulates human macrophage apoptosis via differential signalling through oestrogen receptor-α and βSubramanian M, Shaha C
Journal of Cellular and Molecular Medicine vol. 13 (8B), 2317-2329.
01-01-2009
2007
Up-Regulation of Bcl-2 through ERK Phosphorylation Is Associated with Human Macrophage Survival in an Estrogen MicroenvironmentSubramanian M, Shaha C
The Journal of Immunology, Oxford University Press (Oup) vol. 179 (4), 2330-2338.
15-08-2007
Impaired Macrophage DNase Secretion Promotes Neutrophil Extracellular Trap Mediated Defective Efferocytosis in AtherosclerosisDhawan UK, Vartak T, Englert H, Singhal A, Chakraborty R, Bhagat KK, Vasconcellos LRC, McDonnell C et al.
In Biorxiv
Hypercholesterolemia Impairs Clearance of Extracellular DNA and Promotes Inflammation and Atherosclerotic Plaque ProgressionDhawan UK, Bhattacharya P, Narayanan S, Manickam V, Aggarwal A, Subramanian M
In Biorxiv
Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV-2Naushin S, Sardana V, Ujjainiya R, Bhatheja N, Kutum R, Bhaskar AK, Pradhan S, Prakash S et al.
In Medrxiv
Grants
Macrophage-Secreted DNases in Neutrophil Extracellular Trap Clearance and Atherosclerosis ProgressionManikandan Subramanian
£237,776 BHF British Heart Foundation
01-02-2023 - 31-01-2026
Organelle Reuse by Macrophages During Dead Cell ClearanceManikandan Subramanian
£163,962 BBSRC Biotechnology and Biological Sciences Research Council
01-02-2024 - 15-05-2025
High-Throughput Chemical Screen for Identification of Novel Therapeutic Targets and Regulators of EfManikandan Subramanian
£48,465 Barts and the London Charity
01-08-2022 - 15-02-2024