Dr Manikandan Subramanian
Senior Lecturer
Faculty of Medicine and Dentistry
William Harvey Research Institute
William Harvey Research Institute
Research
Vascular biology, Inflammation, Intercellular communication
Publications
2023
Bhattacharya P, Dhawan UK, Hussain MT, Singh P, Bhagat KK, Singhal A, Austin-Williams S, Sengupta S and Subramanian M (2023). Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling. Elsevier Cell Reports vol. 42, (7) 10.1016/j.celrep.2023.112808
2022
Perretti M and Subramanian M (2022). Resolution pharmacology − A fresh approach to the clinical management of human inflammatory diseases. Elsevier Seminars in Immunology vol. 65, 10.1016/j.smim.2022.101669
Dhawan UK, Margraf A, Lech M and Subramanian M (2022). Hypercholesterolemia promotes autoantibody production and a lupus‐like pathology via decreased DNase‐mediated clearance of DNA. Wiley Journal of Cellular and Molecular Medicine vol. 26, (20) 5267-5276. 10.1111/jcmm.17556
Bhattacharya P, Kanagasooriyan R and Subramanian M (2022). Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond? Elsevier Current Opinion in Pharmacology vol. 66, 10.1016/j.coph.2022.102283
Manickam V, Dhawan UK, Singh D, Gupta M and Subramanian M (2022). Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe -/- Mice. Frontiers Frontiers in Pharmacology vol. 13, 10.3389/fphar.2022.888300
2021
Dhawan UK, Bhattacharya P, Narayanan S, Manickam V, Aggarwal A and Subramanian M (2021). Hypercholesterolemia Impairs Clearance of Neutrophil Extracellular Traps and Promotes Inflammation and Atherosclerotic Plaque Progression. American Heart Association Arteriosclerosis, Thrombosis and Vascular Biology ATVBAHA1203-ATVBAHA1203. 10.1161/ATVBAHA.120.316389
Subramanian M and Marelli-Berg FM (2021). CD36 pumps fat to defang killer T cells in tumors. Elsevier Cell Metabolism vol. 33, (8) 1509-1511. 10.1016/j.cmet.2021.07.004
Dhawan UK, Singhal A and Subramanian M (2021). Dead cell and debris clearance in the atherosclerotic plaque: Mechanisms and therapeutic opportunities to promote inflammation resolution. Elsevier Pharmacological Research vol. 170, 10.1016/j.phrs.2021.105699
Naushin S, Sardana V, Ujjainiya R, Bhatheja N, Kutum R, Bhaskar AK, Pradhan S, Prakash S, Khan R, Rawat BS, Tallapaka KB, Anumalla M, Chandak GR, Lahiri A, Kar S, Mulay SR, Mugale MN, Srivastava M, Khan S, Srivastava A, Tomar B, Veerapandian M, Venkatachalam G, Vijayakumar SR, Agarwal A, Gupta D, Halami PM, Peddha MS, Sundaram GM and Veeranna RP (2021). Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2. Elife Elife vol. 10, 10.7554/elife.66537
DeBerge M, Glinton K, Subramanian M, Wilsbacher LD, Rothlin CV, Tabas I and Thorp EB (2021). Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. American Society For Clinical Investigation Journal of Clinical Investigation vol. 131, (6) 10.1172/jci139576
2020
Yurdagul A, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC, Gerlach BD, Zheng Z, Kuriakose G, Kevil CG, Koomen JM, Cleveland JL, Muoio DM and Tabas I (2020). Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. Elsevier Cell Metabolism vol. 31, (3) 518-533.e10. 10.1016/j.cmet.2020.01.001
2018
Proto JD, Doran AC, Gusarova G, Yurdagul A, Sozen E, Subramanian M, Islam MN, Rymond CC, Du J, Hook J, Kuriakose G, Bhattacharya J and Tabas I (2018). Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Elsevier Immunity vol. 49, (4) 666-677.e6. 10.1016/j.immuni.2018.07.015
Proto JD, Doran AC, Subramanian M, Wang H, Zhang M, Sozen E, Rymond CC, Kuriakose G, D'Agati V, Winchester R, Sykes M, Yang Y-G and Tabas I (2018). Hypercholesterolemia induces T cell expansion in humanized immune mice. American Society For Clinical Investigation Journal of Clinical Investigation vol. 128, (6) 2370-2375. 10.1172/jci97785
2017
Singhal A and Subramanian M (2017). Colony stimulating factors (CSFs): Complex roles in atherosclerosis. Elsevier Cytokine vol. 122, 10.1016/j.cyto.2017.10.012
Wang Y, Subramanian M, Yurdagul A, Barbosa-Lorenzi VC, Cai B, de Juan-Sanz J, Ryan TA, Nomura M, Maxfield FR and Tabas I (2017). Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Elsevier Cell vol. 171, (2) 331-345.e22. 10.1016/j.cell.2017.08.041
2016
Subramanian M, Proto JD, Matsushima GK and Tabas I (2016). Deficiency of AXL in Bone Marrow-Derived Cells Does Not Affect Advanced Atherosclerotic Lesion Progression. Springer Nature Scientific Reports vol. 6, (1) 10.1038/srep39111
Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin C-S, Spite M, Fredman G and Tabas I (2016). MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 113, (23) 6526-6531. 10.1073/pnas.1524292113
Kamaly N, Fredman G, Fojas JJR, Subramanian M, Choi WI, Zepeda K, Vilos C, Yu M, Gadde S, Wu J, Milton J, Leitao RC, Fernandes LR, Hasan M, Gao H, Nguyen V, Harris J, Tabas I and Farokhzad OC (2016). Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis. American Chemical Society (Acs) Acs Nano vol. 10, (5) 5280-5292. 10.1021/acsnano.6b01114
Proto JD, Sozen E, Subramanian M and Tabas I (2016). Expansion of Regulatory T Cells Promotes the Clearance of Apoptotic Cells by Macrophages in Murine Atherosclerotic Plaques. Wiley The Faseb Journal vol. 30, (S1) 10.1096/fasebj.30.1_supplement.1177.16
2015
Subramanian M, Ozcan L, Ghorpade DS, Ferrante AW and Tabas I (2015). Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity. Public Library of Science (Plos) Plos One vol. 10, (8) 10.1371/journal.pone.0135842
Proto J, Subramanian M, Islam M, Hook J, Gusarova G, Bhattacharya J and Tabas I (2015). A Potential Role for Regulatory T Cells in Apoptotic Cell Clearance by Macrophages in a Murine Model of Acute Lung Injury. Wiley The Faseb Journal vol. 29, (S1) 10.1096/fasebj.29.1_supplement.148.3
Subramanian M, Thorp E and Tabas I (2015). Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling. Circ Res vol. 116, (2) e13-e24. 10.1161/CIRCRESAHA.116.304794
Ash D, Subramanian M, Surolia A and Shaha C (2015). Nitric oxide is the key mediator of death induced by fisetin in human acute monocytic leukemia cells. American Journal of Cancer Research vol. 5, (2) 481-497.
2014
Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I, Westerterp M and Tall AR (2014). Interleukin-3/Granulocyte Macrophage Colony–Stimulating Factor Receptor Promotes Stem Cell Expansion, Monocytosis, and Atheroma Macrophage Burden in Mice With Hematopoietic ApoE Deficiency. Wolters Kluwer Arteriosclerosis Thrombosis and Vascular Biology vol. 34, (5) 976-984. 10.1161/atvbaha.113.303097
Subramanian M and Tabas I (2014). A new RIDDle in DC-mediated cross-presentation. Springer Nature Nature Immunology vol. 15, (3) 213-215. 10.1038/ni.2826
Subramanian M, Hayes CD, Thome JJ, Thorp E, Matsushima GK, Herz J, Farber DL, Liu K, Lakshmana M and Tabas I (2014). An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. American Society For Clinical Investigation Journal of Clinical Investigation vol. 124, (3) 1296-1308. 10.1172/jci72051
Westphalen K, Gusarova GA, Islam MN, Subramanian M, Cohen TS, Prince AS and Bhattacharya J (2014). Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Springer Nature Nature vol. 506, (7489) 503-506. 10.1038/nature12902
2013
Subramanian M and Tabas I (2013). Dendritic cells in atherosclerosis. Springer Nature Seminars in Immunopathology vol. 36, (1) 93-102. 10.1007/s00281-013-0400-x
Kamaly N, Fredman G, Subramanian M, Gadde S, Pesic A, Cheung L, Fayad ZA, Langer R, Tabas I and Farokhzad OC (2013). Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles. Proceedings of The National Academy of Sciences Proceedings of The National Academy of Sciences of The United States of America vol. 110, (16) 6506-6511. 10.1073/pnas.1303377110
2012
Subramanian M, Thorp E, Hansson GK and Tabas I (2012). Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs. American Society For Clinical Investigation Journal of Clinical Investigation vol. 123, (1) 179-188. 10.1172/jci64617
Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J and Tabas I (2012). Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis. Elsevier Cell Metabolism vol. 15, (4) 545-553. 10.1016/j.cmet.2012.01.022
2011
Thorp E, Subramanian M and Tabas I (2011). The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis. Wiley European Journal of Immunology vol. 41, (9) 2515-2518. 10.1002/eji.201141719
Thorp E, Vaisar T, Subramanian M, Mautner L, Blobel C and Tabas I (2011). Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK). Elsevier Journal of Biological Chemistry vol. 286, (38) 33335-33344. 10.1074/jbc.m111.263020
2009
Subramanian M and Shaha C (2009). Oestrogen modulates human macrophage apoptosis via differential signalling through oestrogen receptor‐α and β. Wiley Journal of Cellular and Molecular Medicine vol. 13, (8b) 2317-2329. 10.1111/j.1582-4934.2008.00679.x
Subramanian M and Shaha C (2009). Oestrogen modulates human macrophage apoptosis via differential signalling through oestrogen receptor-α and β. Journal of Cellular and Molecular Medicine vol. 13, (8B) 2317-2329. 10.1111/j.1582-4934.2009.00679.x
2007
Subramanian M and Shaha C (2007). Up-Regulation of Bcl-2 through ERK Phosphorylation Is Associated with Human Macrophage Survival in an Estrogen Microenvironment. The American Association of Immunologists The Journal of Immunology vol. 179, (4) 2330-2338. 10.4049/jimmunol.179.4.2330
Grants
Macrophage-Secreted DNases in Neutrophil Extracellular Trap Clearance and Atherosclerosis Progression
Subramanian M
£237,776 British Heart Foundation (01-02-2023 - 31-01-2026)
Subramanian M
£237,776 British Heart Foundation (01-02-2023 - 31-01-2026)
High-Throughput Chemical Screen for Identification of Novel Therapeutic Targets and Regulators of Efferocytosis
Subramanian M
£48,465 Barts Charity (01-08-2022 - 15-02-2024)
Subramanian M
£48,465 Barts Charity (01-08-2022 - 15-02-2024)
Understanding the Role of Efferocyte-Derived Exosomes in Inflammation Resolution
Subramanian M
USD520,470 Wellcome Trust/DBT India Alliance (01-09-2018 - 31-08-2023)
Subramanian M
USD520,470 Wellcome Trust/DBT India Alliance (01-09-2018 - 31-08-2023)
Role of Chronic ER stress in Defective Apoptotic Cell Clearance and Inflammation Resolution
Subramanian M
USD62,852 Department of Biotechnology (17-06-2016 - 17-06-2021)
Subramanian M
USD62,852 Department of Biotechnology (17-06-2016 - 17-06-2021)