Dr Manikandan Subramanian

Manikandan Subramanian

Senior Lecturer

Faculty of Medicine and Dentistry
William Harvey Research Institute


Vascular biology, Inflammation, Intercellular communication

Cardiovascular Models


Publications of specific relevance to Predictive in vitro Models


Bhattacharya P, Dhawan UK, Hussain MT, Singh P, Bhagat KK, Singhal A, Austin-Williams S, Sengupta S and Subramanian M (2023). Efferocytes release extracellular vesicles to resolve inflammation and tissue injury via prosaposin-GPR37 signaling. Elsevier  Cell Reports  vol. 42, (7) 10.1016/j.celrep.2023.112808


Perretti M and Subramanian M (2022). Resolution pharmacology − A fresh approach to the clinical management of human inflammatory diseases. Elsevier  Seminars in Immunology  vol. 65, 10.1016/j.smim.2022.101669
Dhawan UK, Margraf A, Lech M and Subramanian M (2022). Hypercholesterolemia promotes autoantibody production and a lupus‐like pathology via decreased DNase‐mediated clearance of DNA. Wiley  Journal of Cellular and Molecular Medicine  vol. 26, (20) 5267-5276. 10.1111/jcmm.17556
Bhattacharya P, Kanagasooriyan R and Subramanian M (2022). Tackling inflammation in atherosclerosis: Are we there yet and what lies beyond? Elsevier  Current Opinion in Pharmacology  vol. 66, 10.1016/j.coph.2022.102283
Manickam V, Dhawan UK, Singh D, Gupta M and Subramanian M (2022). Pomegranate Peel Extract Decreases Plaque Necrosis and Advanced Atherosclerosis Progression in Apoe -/- Mice. Frontiers  Frontiers in Pharmacology  vol. 13, 10.3389/fphar.2022.888300


Dhawan UK, Bhattacharya P, Narayanan S, Manickam V, Aggarwal A and Subramanian M (2021). Hypercholesterolemia Impairs Clearance of Neutrophil Extracellular Traps and Promotes Inflammation and Atherosclerotic Plaque Progression. American Heart Association  Arteriosclerosis, Thrombosis and Vascular Biology  ATVBAHA1203-ATVBAHA1203. 10.1161/ATVBAHA.120.316389
Subramanian M and Marelli-Berg FM (2021). CD36 pumps fat to defang killer T cells in tumors. Elsevier  Cell Metabolism  vol. 33, (8) 1509-1511. 10.1016/j.cmet.2021.07.004
Dhawan UK, Singhal A and Subramanian M (2021). Dead cell and debris clearance in the atherosclerotic plaque: Mechanisms and therapeutic opportunities to promote inflammation resolution. Elsevier  Pharmacological Research  vol. 170, 10.1016/j.phrs.2021.105699
Naushin S, Sardana V, Ujjainiya R, Bhatheja N, Kutum R, Bhaskar AK, Pradhan S, Prakash S, Khan R, Rawat BS, Tallapaka KB, Anumalla M, Chandak GR, Lahiri A, Kar S, Mulay SR, Mugale MN, Srivastava M, Khan S, Srivastava A, Tomar B, Veerapandian M, Venkatachalam G, Vijayakumar SR, Agarwal A, Gupta D, Halami PM, Peddha MS, Sundaram GM and Veeranna RP (2021). Insights from a Pan India Sero-Epidemiological survey (Phenome-India Cohort) for SARS-CoV2. Elife  Elife  vol. 10, 10.7554/elife.66537
DeBerge M, Glinton K, Subramanian M, Wilsbacher LD, Rothlin CV, Tabas I and Thorp EB (2021). Macrophage AXL receptor tyrosine kinase inflames the heart after reperfused myocardial infarction. American Society For Clinical Investigation  Journal of Clinical Investigation  vol. 131, (6) 10.1172/jci139576


Yurdagul A, Subramanian M, Wang X, Crown SB, Ilkayeva OR, Darville L, Kolluru GK, Rymond CC, Gerlach BD, Zheng Z, Kuriakose G, Kevil CG, Koomen JM, Cleveland JL, Muoio DM and Tabas I (2020). Macrophage Metabolism of Apoptotic Cell-Derived Arginine Promotes Continual Efferocytosis and Resolution of Injury. Elsevier  Cell Metabolism  vol. 31, (3) 518-533.e10. 10.1016/j.cmet.2020.01.001


Proto JD, Doran AC, Gusarova G, Yurdagul A, Sozen E, Subramanian M, Islam MN, Rymond CC, Du J, Hook J, Kuriakose G, Bhattacharya J and Tabas I (2018). Regulatory T Cells Promote Macrophage Efferocytosis during Inflammation Resolution. Elsevier  Immunity  vol. 49, (4) 666-677.e6. 10.1016/j.immuni.2018.07.015
Proto JD, Doran AC, Subramanian M, Wang H, Zhang M, Sozen E, Rymond CC, Kuriakose G, D'Agati V, Winchester R, Sykes M, Yang Y-G and Tabas I (2018). Hypercholesterolemia induces T cell expansion in humanized immune mice. American Society For Clinical Investigation  Journal of Clinical Investigation  vol. 128, (6) 2370-2375. 10.1172/jci97785


Singhal A and Subramanian M (2017). Colony stimulating factors (CSFs): Complex roles in atherosclerosis. Elsevier  Cytokine  vol. 122, 10.1016/j.cyto.2017.10.012
Wang Y, Subramanian M, Yurdagul A, Barbosa-Lorenzi VC, Cai B, de Juan-Sanz J, Ryan TA, Nomura M, Maxfield FR and Tabas I (2017). Mitochondrial Fission Promotes the Continued Clearance of Apoptotic Cells by Macrophages. Elsevier  Cell  vol. 171, (2) 331-345.e22. 10.1016/j.cell.2017.08.041


Subramanian M, Proto JD, Matsushima GK and Tabas I (2016). Deficiency of AXL in Bone Marrow-Derived Cells Does Not Affect Advanced Atherosclerotic Lesion Progression. Springer Nature  Scientific Reports  vol. 6, (1) 10.1038/srep39111
Cai B, Thorp EB, Doran AC, Subramanian M, Sansbury BE, Lin C-S, Spite M, Fredman G and Tabas I (2016). MerTK cleavage limits proresolving mediator biosynthesis and exacerbates tissue inflammation. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 113, (23) 6526-6531. 10.1073/pnas.1524292113
Kamaly N, Fredman G, Fojas JJR, Subramanian M, Choi WI, Zepeda K, Vilos C, Yu M, Gadde S, Wu J, Milton J, Leitao RC, Fernandes LR, Hasan M, Gao H, Nguyen V, Harris J, Tabas I and Farokhzad OC (2016). Targeted Interleukin-10 Nanotherapeutics Developed with a Microfluidic Chip Enhance Resolution of Inflammation in Advanced Atherosclerosis. American Chemical Society (Acs)  Acs Nano  vol. 10, (5) 5280-5292. 10.1021/acsnano.6b01114
Proto JD, Sozen E, Subramanian M and Tabas I (2016). Expansion of Regulatory T Cells Promotes the Clearance of Apoptotic Cells by Macrophages in Murine Atherosclerotic Plaques. Wiley  The Faseb Journal  vol. 30, (S1) 10.1096/fasebj.30.1_supplement.1177.16


Subramanian M, Ozcan L, Ghorpade DS, Ferrante AW and Tabas I (2015). Suppression of Adaptive Immune Cell Activation Does Not Alter Innate Immune Adipose Inflammation or Insulin Resistance in Obesity. Public Library of Science (Plos)  Plos One  vol. 10, (8) 10.1371/journal.pone.0135842
Proto J, Subramanian M, Islam M, Hook J, Gusarova G, Bhattacharya J and Tabas I (2015). A Potential Role for Regulatory T Cells in Apoptotic Cell Clearance by Macrophages in a Murine Model of Acute Lung Injury. Wiley  The Faseb Journal  vol. 29, (S1) 10.1096/fasebj.29.1_supplement.148.3
Subramanian M, Thorp E and Tabas I (2015). Identification of a non-growth factor role for GM-CSF in advanced atherosclerosis: promotion of macrophage apoptosis and plaque necrosis through IL-23 signaling. Circ Res  vol. 116, (2) e13-e24. 10.1161/CIRCRESAHA.116.304794
Ash D, Subramanian M, Surolia A and Shaha C (2015). Nitric oxide is the key mediator of death induced by fisetin in human acute monocytic leukemia cells. American Journal of Cancer Research  vol. 5, (2) 481-497.


Wang M, Subramanian M, Abramowicz S, Murphy AJ, Gonen A, Witztum J, Welch C, Tabas I, Westerterp M and Tall AR (2014). Interleukin-3/Granulocyte Macrophage Colony–Stimulating Factor Receptor Promotes Stem Cell Expansion, Monocytosis, and Atheroma Macrophage Burden in Mice With Hematopoietic ApoE Deficiency. Wolters Kluwer  Arteriosclerosis Thrombosis and Vascular Biology  vol. 34, (5) 976-984. 10.1161/atvbaha.113.303097
Subramanian M and Tabas I (2014). A new RIDDle in DC-mediated cross-presentation. Springer Nature  Nature Immunology  vol. 15, (3) 213-215. 10.1038/ni.2826
Subramanian M, Hayes CD, Thome JJ, Thorp E, Matsushima GK, Herz J, Farber DL, Liu K, Lakshmana M and Tabas I (2014). An AXL/LRP-1/RANBP9 complex mediates DC efferocytosis and antigen cross-presentation in vivo. American Society For Clinical Investigation  Journal of Clinical Investigation  vol. 124, (3) 1296-1308. 10.1172/jci72051
Westphalen K, Gusarova GA, Islam MN, Subramanian M, Cohen TS, Prince AS and Bhattacharya J (2014). Sessile alveolar macrophages communicate with alveolar epithelium to modulate immunity. Springer Nature  Nature  vol. 506, (7489) 503-506. 10.1038/nature12902


Subramanian M and Tabas I (2013). Dendritic cells in atherosclerosis. Springer Nature  Seminars in Immunopathology  vol. 36, (1) 93-102. 10.1007/s00281-013-0400-x
Kamaly N, Fredman G, Subramanian M, Gadde S, Pesic A, Cheung L, Fayad ZA, Langer R, Tabas I and Farokhzad OC (2013). Development and in vivo efficacy of targeted polymeric inflammation-resolving nanoparticles. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 110, (16) 6506-6511. 10.1073/pnas.1303377110


Subramanian M, Thorp E, Hansson GK and Tabas I (2012). Treg-mediated suppression of atherosclerosis requires MYD88 signaling in DCs. American Society For Clinical Investigation  Journal of Clinical Investigation  vol. 123, (1) 179-188. 10.1172/jci64617
Liao X, Sluimer JC, Wang Y, Subramanian M, Brown K, Pattison JS, Robbins J, Martinez J and Tabas I (2012). Macrophage Autophagy Plays a Protective Role in Advanced Atherosclerosis. Elsevier  Cell Metabolism  vol. 15, (4) 545-553. 10.1016/j.cmet.2012.01.022


Thorp E, Subramanian M and Tabas I (2011). The role of macrophages and dendritic cells in the clearance of apoptotic cells in advanced atherosclerosis. Wiley  European Journal of Immunology  vol. 41, (9) 2515-2518. 10.1002/eji.201141719
Thorp E, Vaisar T, Subramanian M, Mautner L, Blobel C and Tabas I (2011). Shedding of the Mer Tyrosine Kinase Receptor Is Mediated by ADAM17 Protein through a Pathway Involving Reactive Oxygen Species, Protein Kinase Cδ, and p38 Mitogen-activated Protein Kinase (MAPK). Elsevier  Journal of Biological Chemistry  vol. 286, (38) 33335-33344. 10.1074/jbc.m111.263020


Subramanian M and Shaha C (2009). Oestrogen modulates human macrophage apoptosis via differential signalling through oestrogen receptor‐α and β. Wiley  Journal of Cellular and Molecular Medicine  vol. 13, (8b) 2317-2329. 10.1111/j.1582-4934.2008.00679.x
Subramanian M and Shaha C (2009). Oestrogen modulates human macrophage apoptosis via differential signalling through oestrogen receptor-α and β. Journal of Cellular and Molecular Medicine  vol. 13, (8B) 2317-2329. 10.1111/j.1582-4934.2009.00679.x


Subramanian M and Shaha C (2007). Up-Regulation of Bcl-2 through ERK Phosphorylation Is Associated with Human Macrophage Survival in an Estrogen Microenvironment. The American Association of Immunologists  The Journal of Immunology  vol. 179, (4) 2330-2338. 10.4049/jimmunol.179.4.2330


Grants of specific relevance to Predictive in vitro Models
Macrophage-Secreted DNases in Neutrophil Extracellular Trap Clearance and Atherosclerosis Progression
Subramanian M
£237,776 British Heart Foundation (01-02-2023 - 31-01-2026)

High-Throughput Chemical Screen for Identification of Novel Therapeutic Targets and Regulators of Efferocytosis
Subramanian M
£48,465 Barts Charity (01-08-2022 - 15-02-2024)
Understanding the Role of Efferocyte-Derived Exosomes in Inflammation Resolution
Subramanian M
USD520,470 Wellcome Trust/DBT India Alliance (01-09-2018 - 31-08-2023)
Role of Chronic ER stress in Defective Apoptotic Cell Clearance and Inflammation Resolution
Subramanian M
USD62,852 Department of Biotechnology (17-06-2016 - 17-06-2021)