Dr Marco Pensalfini

Marco Pensalfini

Lecturer in Mechanical and Biomedical Engineering

School of Engineering and Materials Science
Queen Mary University of London
ResearcherID ORCID Google Scholar LinkedIn X


Bioengineering, Wound Healing, Multiscale Biomechanics, Computational Modeling, Biomaterials, Bioinspired Design

Underpinning Bioengineering, Skin Models


Computational modeling of spatial patterning in biological systems to rationalize the contribution of microstructural constituents towards cell- and tissue-scale load bearing. Recent work focused on simulations of new tissue formation and remodeling in wound healing, as well as self-organization in cytoskeletal systems such as F-actin and intermediate filament networks.


Publications of specific relevance to Predictive in vitro Models


Pensalfini M, Golde T, Trepat X and Arroyo M (2023). Nonaffine Mechanics of Entangled Networks Inspired by Intermediate Filaments. American Physical Society (Aps)  Physical Review Letters  vol. 131, (5) 10.1103/physrevlett.131.058101
Pensalfini M and Tepole AB (2023). Mechano-biological and bio-mechanical pathways in cutaneous wound healing. Public Library of Science (Plos)  Plos Computational Biology  vol. 19, (3) 10.1371/journal.pcbi.1010902


Pensalfini M, Rotach M, Hopf R, Bielicki A, Santoprete R and Mazza E (2020). How cosmetic tightening products modulate the biomechanics and morphology of human skin. Elsevier  Acta Biomaterialia  vol. 115, 299-316. 10.1016/j.actbio.2020.08.027
Wietecha MS, Pensalfini M, Cangkrama M, Müller B, Jin J, Brinckmann J, Mazza E and Werner S (2020). Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds. Springer Nature  Nature Communications  vol. 11, (1) 10.1038/s41467-020-16409-z


Wahlsten A, Pensalfini M, Stracuzzi A, Restivo G, Hopf R and Mazza E (2019). On the compressibility and poroelasticity of human and murine skin. Springer Nature  Biomechanics and Modeling in Mechanobiology  vol. 18, (4) 1079-1093. 10.1007/s10237-019-01129-1
Bircher K, Zündel M, Pensalfini M, Ehret AE and Mazza E (2019). Tear resistance of soft collagenous tissues. Springer Nature  Nature Communications  vol. 10, (1) 10.1038/s41467-019-08723-y


Lintas V, Fioretta ES, Motta SE, Dijkman PE, Pensalfini M, Mazza E, Caliskan E, Rodriguez H, Lipiski M, Sauer M, Cesarovic N, Hoerstrup SP and Emmert MY (2018). Development of a Novel Human Cell-Derived Tissue-Engineered Heart Valve for Transcatheter Aortic Valve Replacement: an In Vitro and In Vivo Feasibility Study. Springer Nature  Journal of Cardiovascular Translational Research  vol. 11, (6) 470-482. 10.1007/s12265-018-9821-1
Müller B, Elrod J, Pensalfini M, Hopf R, Distler O, Schiestl C and Mazza E (2018). A novel ultra-light suction device for mechanical characterization of skin. Public Library of Science (Plos)  Plos One  vol. 13, (8) 10.1371/journal.pone.0201440


Pensalfini M, Weickenmeier J, Rominger M, Santoprete R, Distler O and Mazza E (2017). Location-specific mechanical response and morphology of facial soft tissues. Elsevier  Journal of The Mechanical Behavior of Biomedical Materials  vol. 78, 108-115. 10.1016/j.jmbbm.2017.10.021
Pensalfini M, Haertel E, Hopf R, Wietecha M, Werner S and Mazza E (2017). The mechanical fingerprint of murine excisional wounds. Elsevier  Acta Biomaterialia  vol. 65, 226-236. 10.1016/j.actbio.2017.10.021
Pensalfini M, Meneghello S, Lintas V, Bircher K, Ehret AE and Mazza E (2017). The suture retention test, revisited and revised. Elsevier  Journal of The Mechanical Behavior of Biomedical Materials  vol. 77, 711-717. 10.1016/j.jmbbm.2017.08.021


Pensalfini M, Ehret AE, Stüdeli S, Marino D, Kaech A, Reichmann E and Mazza E (2016). Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering. Elsevier  Journal of The Mechanical Behavior of Biomedical Materials  vol. 69, 85-97. 10.1016/j.jmbbm.2016.12.004
Kesti M, Fisch P, Pensalfini M, Mazza E and Zenobi-Wong M (2016). Guidelines for standardization of bioprinting: a systematic study of process parameters and their effect on bioprinted structures. De Gruyter  Bionanomaterials  vol. 17, (3-4) 193-204. 10.1515/bnm-2016-0004


Maurer MM, Badir S, Pensalfini M, Bajka M, Abitabile P, Zimmermann R and Mazza E (2015). Challenging the in-vivo assessment of biomechanical properties of the uterine cervix: A critical analysis of ultrasound based quasi-static procedures. Elsevier  Journal of Biomechanics  vol. 48, (9) 1541-1548. 10.1016/j.jbiomech.2015.02.038


Pensalfini M, Duenwald-Kuehl S, Kondratko-Mittnacht J, Lakes R and Vanderby R (2014). Evaluation of Global Load Sharing and Shear-Lag Models to Describe Mechanical Behavior in Partially Lacerated Tendons. Asme International  Journal of Biomechanical Engineering  vol. 136, (9) 10.1115/1.4027714