Dr Marco Pensalfini

Marco Pensalfini

Lecturer in Mechanical and Biomedical Engineering

School of Engineering and Materials Science
Queen Mary University of London
ResearcherID ORCID Google Scholar LinkedIn X

Research

Bioengineering, Wound Healing, Multiscale Biomechanics, Computational Modeling, Biomaterials, Bioinspired Design

Underpinning Bioengineering, Skin Models

Interests

Computational modeling of spatial patterning in biological systems to rationalize the contribution of microstructural constituents towards cell- and tissue-scale load bearing. Recent work focused on simulations of new tissue formation and remodeling in wound healing, as well as self-organization in cytoskeletal systems such as F-actin and intermediate filament networks.

Publications

Publications of specific relevance to Predictive in vitro Models

2023

Pensalfini M, Golde T, Trepat X and Arroyo M (2023). Nonaffine Mechanics of Entangled Networks Inspired by Intermediate Filaments. American Physical Society (Aps)  Physical Review Letters  vol. 131, (5) 10.1103/physrevlett.131.058101
Pensalfini M and Tepole AB (2023). Mechano-biological and bio-mechanical pathways in cutaneous wound healing. Public Library of Science (Plos)  Plos Computational Biology  vol. 19, (3) 10.1371/journal.pcbi.1010902

2020

Pensalfini M, Rotach M, Hopf R, Bielicki A, Santoprete R and Mazza E (2020). How cosmetic tightening products modulate the biomechanics and morphology of human skin. Elsevier  Acta Biomaterialia  vol. 115, 299-316. 10.1016/j.actbio.2020.08.027
Wietecha MS, Pensalfini M, Cangkrama M, Müller B, Jin J, Brinckmann J, Mazza E and Werner S (2020). Activin-mediated alterations of the fibroblast transcriptome and matrisome control the biomechanical properties of skin wounds. Springer Nature  Nature Communications  vol. 11, (1) 10.1038/s41467-020-16409-z

2019

Wahlsten A, Pensalfini M, Stracuzzi A, Restivo G, Hopf R and Mazza E (2019). On the compressibility and poroelasticity of human and murine skin. Springer Nature  Biomechanics and Modeling in Mechanobiology  vol. 18, (4) 1079-1093. 10.1007/s10237-019-01129-1
Bircher K, Zündel M, Pensalfini M, Ehret AE and Mazza E (2019). Tear resistance of soft collagenous tissues. Springer Nature  Nature Communications  vol. 10, (1) 10.1038/s41467-019-08723-y

2018

Lintas V, Fioretta ES, Motta SE, Dijkman PE, Pensalfini M, Mazza E, Caliskan E, Rodriguez H, Lipiski M, Sauer M, Cesarovic N, Hoerstrup SP and Emmert MY (2018). Development of a Novel Human Cell-Derived Tissue-Engineered Heart Valve for Transcatheter Aortic Valve Replacement: an In Vitro and In Vivo Feasibility Study. Springer Nature  Journal of Cardiovascular Translational Research  vol. 11, (6) 470-482. 10.1007/s12265-018-9821-1
Müller B, Elrod J, Pensalfini M, Hopf R, Distler O, Schiestl C and Mazza E (2018). A novel ultra-light suction device for mechanical characterization of skin. Public Library of Science (Plos)  Plos One  vol. 13, (8) 10.1371/journal.pone.0201440

2017

Pensalfini M, Weickenmeier J, Rominger M, Santoprete R, Distler O and Mazza E (2017). Location-specific mechanical response and morphology of facial soft tissues. Elsevier  Journal of The Mechanical Behavior of Biomedical Materials  vol. 78, 108-115. 10.1016/j.jmbbm.2017.10.021
Pensalfini M, Haertel E, Hopf R, Wietecha M, Werner S and Mazza E (2017). The mechanical fingerprint of murine excisional wounds. Elsevier  Acta Biomaterialia  vol. 65, 226-236. 10.1016/j.actbio.2017.10.021
Pensalfini M, Meneghello S, Lintas V, Bircher K, Ehret AE and Mazza E (2017). The suture retention test, revisited and revised. Elsevier  Journal of The Mechanical Behavior of Biomedical Materials  vol. 77, 711-717. 10.1016/j.jmbbm.2017.08.021

2016

Pensalfini M, Ehret AE, Stüdeli S, Marino D, Kaech A, Reichmann E and Mazza E (2016). Factors affecting the mechanical behavior of collagen hydrogels for skin tissue engineering. Elsevier  Journal of The Mechanical Behavior of Biomedical Materials  vol. 69, 85-97. 10.1016/j.jmbbm.2016.12.004
Kesti M, Fisch P, Pensalfini M, Mazza E and Zenobi-Wong M (2016). Guidelines for standardization of bioprinting: a systematic study of process parameters and their effect on bioprinted structures. De Gruyter  Bionanomaterials  vol. 17, (3-4) 193-204. 10.1515/bnm-2016-0004

2015

Maurer MM, Badir S, Pensalfini M, Bajka M, Abitabile P, Zimmermann R and Mazza E (2015). Challenging the in-vivo assessment of biomechanical properties of the uterine cervix: A critical analysis of ultrasound based quasi-static procedures. Elsevier  Journal of Biomechanics  vol. 48, (9) 1541-1548. 10.1016/j.jbiomech.2015.02.038

2014

Pensalfini M, Duenwald-Kuehl S, Kondratko-Mittnacht J, Lakes R and Vanderby R (2014). Evaluation of Global Load Sharing and Shear-Lag Models to Describe Mechanical Behavior in Partially Lacerated Tendons. Asme International  Journal of Biomechanical Engineering  vol. 136, (9) 10.1115/1.4027714