Research
osteoarthritis, cartilage repair and regeneration, alpha-1-antitrypsin, pro-resolving mediators, inflammation resolution
Musculoskeletal Models
Interests
My research focus is on harnessing the properties of endogenous pro-resolving molecules, defining their biology and cartilage reparative signatures to inform innovative therapeutic approaches for the treatment of osteoarthritis and joint pathologies.
As such, I am interested in the development of in vitro models of chondrogenesis that can accurately predict the cartilage regenerative potential of drug candidates in vivo.
Publications
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Publications of specific relevance to Predictive in vitro Models
2022
Kaneva MK (2022).
Neutrophil elastase and its inhibitors-overlooked players in osteoarthritis. Febs J vol. 289, (1) 113-116.
10.1111/febs.161942021
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Eldridge S, Barawi A, Wang H, Roelofs A,
Kaneva M, Guan Z, Lydon H, Thomas B, Thorup AS, Fernandez BF, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, Mccaskie A, De Bari C and Dell’accio F (2021).
AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. Annals of The Rheumatic Diseases vol. 80, (Suppl 1) 1052.1-101052.
10.1136/annrheumdis-2021-eular.2584
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ and
Perretti M (2021).
Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis. Wiley The Faseb Journal vol. 35, (5)
10.1096/fj.202001801r![](/publications/bullet24.png)
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F,
Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F,
Perretti M, D’Amico M and Di Filippo C (2021).
Corrigendum to “Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy”. Hindawi Mediators of Inflammation vol. 2021,
10.1155/2021/98614342020
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Eldridge SE, Barawi A, Wang H, Roelofs AJ,
Kaneva M, GUAN Z, Lydon H, Thomas B, Thorup A-S, Fernandez-Fernandez B, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, McCaskie AW, De Bari C and Dell'Accio F (2020).
Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. American Association For The Advancement of Science Science Translational Medicine vol. 12, (559)
10.1126/scitranslmed.aax9086![](/publications/bullet24.png)
Can VC, Locke IC,
Kaneva MK, Kerrigan MJP, Merlino F, De Pascale C, Grieco P and Getting SJ (2020).
Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes. Elsevier European Journal of Pharmacology vol. 872,
10.1016/j.ejphar.2020.1729712017
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and
Perretti M (2017).
Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates. The American Association of Immunologists The Journal of Immunology vol. 198, (7) 2876-2885.
10.4049/jimmunol.16011112016
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Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F,
Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F,
Perretti M, D'Amico M and Di Filippo C (2016).
Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Hindawi Mediators of Inflammation vol. 2016,
10.1155/2016/73683892014
Kaneva MK, Kerrigan MJP, Grieco P, Curley GP, Locke IC and Getting SJ (2014).
Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Elsevier Biochemical Pharmacology vol. 92, (2) 336-347.
10.1016/j.bcp.2014.08.019![](/publications/fav.png)
Greco KV, Nalesso G,
Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell’Accio F and
Perretti M (2014).
Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Elsevier Biochemical Pharmacology vol. 91, (3) 348-358.
10.1016/j.bcp.2014.07.0342012
Kaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC and Getting SJ (2012).
Chondroprotective and anti‐inflammatory role of melanocortin peptides in TNF‐α activated human C‐20/A4 chondrocytes. Wiley British Journal of Pharmacology vol. 167, (1) 67-79.
10.1111/j.1476-5381.2012.01968.x![](/publications/bullet24.png)
Qusous A,
Kaneva M, Can VC, Getting SJ and Kerrigan MJP (2012).
The phenotypic characterization of A13/BACii, a novel bovine chondrocytic cell line with differentiation potential. Cells Tissues Organs vol. 196, (3) 251-261.
10.1159/0003321442009
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Getting SJ,
Kaneva M, Bhadresa Y, Renshaw D, Leoni G, Patel HB, Kerrigan MJP and Locke IC (2009).
Melanocortin peptide therapy for the treatment of arthritic pathologies. Scientificworldjournal vol. 9, 1394-1414.
10.1100/tsw.2009.1632008