Dr Magdalena K Kaneva

Magdalena K Kaneva
BSc, PhD, AFHEA

Postdoctoral research fellow

Barts and the London School of Medicine and Dentistry
William Harvey Research Institute
ORCID Google Scholar LinkedIn X

Research

osteoarthritis, cartilage repair and regeneration, alpha-1-antitrypsin, pro-resolving mediators, inflammation resolution

Musculoskeletal Models

Interests

My research focus is on harnessing the properties of endogenous pro-resolving molecules, defining their biology and cartilage reparative signatures to inform innovative therapeutic approaches for the treatment of osteoarthritis and joint pathologies. As such, I am interested in the development of in vitro models of chondrogenesis that can accurately predict the cartilage regenerative potential of drug candidates in vivo.

Publications

Publications of specific relevance to Predictive in vitro Models

2022

Kaneva MK (2022). Neutrophil elastase and its inhibitors-overlooked players in osteoarthritis. Febs J  vol. 289, (1) 113-116. 10.1111/febs.16194

2021

Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B, Thorup AS, Fernandez BF, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, Mccaskie A, De Bari C and Dell’accio F (2021). AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. Annals of The Rheumatic Diseases  vol. 80, (Suppl 1) 1052.1-101052. 10.1136/annrheumdis-2021-eular.2584
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ and Perretti M (2021). Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis. Wiley  The Faseb Journal  vol. 35, (5) 10.1096/fj.202001801r
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D’Amico M and Di Filippo C (2021). Corrigendum to “Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy”. Hindawi  Mediators of Inflammation  vol. 2021, 10.1155/2021/9861434

2020

Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B, Thorup A-S, Fernandez-Fernandez B, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, McCaskie AW, De Bari C and Dell'Accio F (2020). Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. American Association For The Advancement of Science  Science Translational Medicine  vol. 12, (559) 10.1126/scitranslmed.aax9086
Can VC, Locke IC, Kaneva MK, Kerrigan MJP, Merlino F, De Pascale C, Grieco P and Getting SJ (2020). Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes. Elsevier  European Journal of Pharmacology  vol. 872, 10.1016/j.ejphar.2020.172971

2017

Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and Perretti M (2017). Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates. The American Association of Immunologists  The Journal of Immunology  vol. 198, (7) 2876-2885. 10.4049/jimmunol.1601111

2016

Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D'Amico M and Di Filippo C (2016). Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Hindawi  Mediators of Inflammation  vol. 2016, 10.1155/2016/7368389

2014

Kaneva MK, Kerrigan MJP, Grieco P, Curley GP, Locke IC and Getting SJ (2014). Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Elsevier  Biochemical Pharmacology  vol. 92, (2) 336-347. 10.1016/j.bcp.2014.08.019
Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell’Accio F and Perretti M (2014). Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Elsevier  Biochemical Pharmacology  vol. 91, (3) 348-358. 10.1016/j.bcp.2014.07.034
Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D and Perretti M (2014). Resolution of inflammation: examples of peptidergic players and pathways. Elsevier  Drug Discovery Today  vol. 19, (8) 1166-1171. 10.1016/j.drudis.2014.05.020

2012

Kaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC and Getting SJ (2012). Chondroprotective and anti‐inflammatory role of melanocortin peptides in TNF‐α activated human C‐20/A4 chondrocytes. Wiley  British Journal of Pharmacology  vol. 167, (1) 67-79. 10.1111/j.1476-5381.2012.01968.x
Qusous A, Kaneva M, Can VC, Getting SJ and Kerrigan MJP (2012). The phenotypic characterization of A13/BACii, a novel bovine chondrocytic cell line with differentiation potential. Cells Tissues Organs  vol. 196, (3) 251-261. 10.1159/000332144

2009

Getting SJ, Kaneva M, Bhadresa Y, Renshaw D, Leoni G, Patel HB, Kerrigan MJP and Locke IC (2009). Melanocortin peptide therapy for the treatment of arthritic pathologies. Scientificworldjournal  vol. 9, 1394-1414. 10.1100/tsw.2009.163

2008

Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M and Spina D (2008). A role for MC3R in modulating lung inflammation. Pulm Pharmacol Ther  vol. 21, (6) 866-873. 10.1016/j.pupt.2008.09.004

Grants

Grants of specific relevance to Predictive in vitro Models
INBRX-101 for cartilage repair in arthritis
Kaneva M
£97,500 Inhibrx Inc (01-03-2022 - 28-02-2023)
Targeting Feutin-A as an innovative chondroprotective strategy
Perretti M and Kaneva M
William Harvey Research Limited (01-03-2014 - 28-02-2018)
Summary