Dr Magdalena K Kaneva
BSc, PhD, FHEALecturer in Regenerative Pharmacology
Barts and the London School of Medicine and Dentistry
William Harvey Research Institute
William Harvey Research Institute
Research
osteoarthritis, cartilage repair and regeneration, alpha-1-antitrypsin, pro-resolving mediators, inflammation resolution
Interests
My research focus is on harnessing the properties of endogenous pro-resolving molecules, defining their biology and cartilage reparative signatures to inform innovative therapeutic approaches for the treatment of osteoarthritis and joint pathologies. As such, I am interested in the development of in vitro models of chondrogenesis that can accurately predict the cartilage regenerative potential of drug candidates in vivo.Publications
Publications of specific relevance to Predictive in vitro Models
2024
Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D, Austin‐Williams S, Hussain MT, Pitzalis C, Allen B, Malcangio M, Dell'Accio F, Norling LV and Perretti M (2024). Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis. Wiley Arthritis & Rheumatology 10.1002/art.42958
2022
Eldridge S, Barawi A, Thorup AS, Fernandez BF, Bharde S, Sikandar S, Guan Z, Kaneva M, Lydon H, Henson F, De Bari C, McCaskie A and Dell’Accio F (2022). AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS. Bmj Annals of The Rheumatic Diseases vol. 81, (Suppl 1) 1208.1-121208. 10.1136/annrheumdis-2022-eular.3483
Kaneva MK (2022). Neutrophil elastase and its inhibitors-overlooked players in osteoarthritis. Febs J vol. 289, (1) 113-116. 10.1111/febs.16194
2021
Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B, Thorup AS, Fernandez BF, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, Mccaskie A, De Bari C and Dell’accio F (2021). AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO. Annals of The Rheumatic Diseases vol. 80, (Suppl 1) 1052.1-101052. 10.1136/annrheumdis-2021-eular.2584
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ and Perretti M (2021). Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis. Wiley The Faseb Journal vol. 35, (5) 10.1096/fj.202001801r
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D’Amico M and Di Filippo C (2021). Corrigendum to “Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy”. Hindawi Mediators of Inflammation vol. 2021, 10.1155/2021/9861434
2020
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, GUAN Z, Lydon H, Thomas B, Thorup A-S, Fernandez-Fernandez B, Caxaria S, Strachan D, Ali A, Shanmuganathan K, Pitzalis C, Whiteford J, Henson F, McCaskie AW, De Bari C and Dell'Accio F (2020). Agrin induces long term osteochondral regeneration by supporting repair morphogenesis. American Association For The Advancement of Science Science Translational Medicine vol. 12, (559) 10.1126/scitranslmed.aax9086
Can VC, Locke IC, Kaneva MK, Kerrigan MJP, Merlino F, De Pascale C, Grieco P and Getting SJ (2020). Novel anti-inflammatory and chondroprotective effects of the human melanocortin MC1 receptor agonist BMS-470539 dihydrochloride and human melanocortin MC3 receptor agonist PG-990 on lipopolysaccharide activated chondrocytes. Elsevier European Journal of Pharmacology vol. 872, 10.1016/j.ejphar.2020.172971
2017
Kaneva MK, Greco KV, Headland SE, Montero-Melendez T, Mori P, Greenslade K, Pitzalis C, Moore A and Perretti M (2017). Identification of Novel Chondroprotective Mediators in Resolving Inflammatory Exudates. The American Association of Immunologists The Journal of Immunology vol. 198, (7) 2876-2885. 10.4049/jimmunol.1601111
2016
Rossi S, Maisto R, Gesualdo C, Trotta MC, Ferraraccio F, Kaneva MK, Getting SJ, Surace E, Testa F, Simonelli F, Grieco P, Merlino F, Perretti M, D'Amico M and Di Filippo C (2016). Activation of Melanocortin Receptors MC1 and MC5 Attenuates Retinal Damage in Experimental Diabetic Retinopathy. Hindawi Mediators of Inflammation vol. 2016, 10.1155/2016/7368389
2014
Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F and Perretti M (2014). Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin. Biochem Pharmacol vol. 91, (3) 348-358. 10.1016/j.bcp.2014.07.034
Kaneva MK, Kerrigan MJP, Grieco P, Curley GP, Locke IC and Getting SJ (2014). Melanocortin peptides protect chondrocytes from mechanically induced cartilage injury. Elsevier Biochemical Pharmacology vol. 92, (2) 336-347. 10.1016/j.bcp.2014.08.019
Ahmed TJ, Kaneva MK, Pitzalis C, Cooper D and Perretti M (2014). Resolution of inflammation: examples of peptidergic players and pathways. Drug Discov Today vol. 19, (8) 1166-1171. 10.1016/j.drudis.2014.05.020
2012
Kaneva MK, Kerrigan MJ, Grieco P, Curley GP, Locke IC and Getting SJ (2012). Chondroprotective and anti‐inflammatory role of melanocortin peptides in TNF‐α activated human C‐20/A4 chondrocytes. Wiley British Journal of Pharmacology vol. 167, (1) 67-79. 10.1111/j.1476-5381.2012.01968.x
Qusous A, Kaneva M, Can VC, Getting SJ and Kerrigan MJP (2012). The phenotypic characterization of A13/BACii, a novel bovine chondrocytic cell line with differentiation potential. Cells Tissues Organs vol. 196, (3) 251-261. 10.1159/000332144
2009
Getting SJ, Kaneva M, Bhadresa Y, Renshaw D, Leoni G, Patel HB, Kerrigan MJP and Locke IC (2009). Melanocortin peptide therapy for the treatment of arthritic pathologies. Scientificworldjournal vol. 9, 1394-1414. 10.1100/tsw.2009.163
2008
Getting SJ, Riffo-Vasquez Y, Pitchford S, Kaneva M, Grieco P, Page CP, Perretti M and Spina D (2008). A role for MC3R in modulating lung inflammation. Pulm Pharmacol Ther vol. 21, (6) 866-873. 10.1016/j.pupt.2008.09.004
Grants
Grants of specific relevance to Predictive in vitro Models
Targeting Feutin-A as an innovative chondroprotective strategy
Perretti M and Kaneva M
William Harvey Research Limited (01-03-2014 - 28-02-2018)
Perretti M and Kaneva M
William Harvey Research Limited (01-03-2014 - 28-02-2018)