Dr Luigi Ombrato
Group Leader / Lecturer
Barts Cancer Institute
Queen Mary University of London
Queen Mary University of London
Research
Tumour Microenvironment, Metastasis, Immune cells, Stromal cells, Immunotherapy
Interests
Our lab uses 3D models (including heterotypic spheroids/tumoroids, transwell scaffolds, hydrogels) to study the interactions between cancer cells, stromal cells and immune cells. These systems help us to dissect the molecular mechanims underlying metastasis formation and to understand how the different cellular components within the tumour microenvironment communicate with each others and with the cancer cells during the establishment of a tumour supportive niche. Cancers of interest: breast, colorectal, pancreatic.Publications

2024

Ermogenous C, Ombrato L and Beattie G
Cancer Research, American Association For Cancer Research (Aacr) vol. 84 (22_Supplement), b022-b022.
17-11-2024

Perdrix Rosell A, Maiques O, Martin JAJ, Chakravarty P, Ombrato L, Sanz-Moreno V and Malanchi I
Cancer Letters, Elsevier vol. 597
01-07-2024

Rodrigues FS, Karoutas A, Ruhland S, Rabas N, Rizou T, Di Blasio S, Ferreira RMM, Bridgeman VL, Goldstone R, Sopena ML, Lee J-H, Ombrato L and Malanchi I
Developmental Cell, Elsevier vol. 59 (18), 2398-2413.e8.
11-06-2024
2023

Kafka A, Ermogenous C and Ombrato L
Methods in Molecular Biology, Springer Nature vol. 2748, 1-12.
10-12-2023
2022

Ombrato L
Nature Reviews Cancer, Springer Nature vol. 22 (12), 661-661.
29-09-2022

Perdrix Rosell A, Maiques O, Martin JAJ, Chakravarty P, Ombrato L, Sanz-Moreno V and Malanchi I
Cancer Letters, Elsevier vol. 544
06-07-2022

Borel V, Boeing S, Van Wietmarschen N, Sridharan S, Hill BR, Ombrato L, Perez-Lloret J, Jackson D, Goldstone R, Boulton SJ, Nussenzweig A and Bellelli R
Cell Reports, Elsevier vol. 39 (9)
01-05-2022

Nolan E, Bridgeman VL, Ombrato L, Karoutas A, Rabas N, Sewnath CAN, Vasquez M, Rodrigues FS, Horswell S, Faull P, Carter R and Malanchi I
Nature Cancer, Springer Nature vol. 3 (4), 519-519.
01-04-2022

Nolan E, Bridgeman VL, Ombrato L, Karoutas A, Rabas N, Sewnath CAN, Vasquez M, Rodrigues FS, Horswell S, Faull P, Carter R and Malanchi I
Nature Cancer, Springer Nature vol. 3 (2), 173-187.
01-02-2022
2021

Rosell AP, Maiques O, Chakravarty P, Ombrato L, Sanz-Moreno V and Malanchi I
, Cold Spring Harbor Laboratory
15-06-2021

Passaro D, Garcia-Albornoz M, Diana G, Chakravarty P, Ariza-McNaughton L, Batsivari A, Borràs-Eroles C, Abarrategi A, Waclawiczek A, Ombrato L, Malanchi I, Gribben J and Bonnet D
Cell Reports, Elsevier vol. 35 (6)
01-05-2021
2020

Ombrato L, Nolan E, Passaro D, Kurelac I, Bridgeman VL, Waclawiczek A, Duarte D, Lo Celso C, Bonnet D and Malanchi I
Nature Protocols, Springer Nature vol. 16 (2), 872-892.
11-12-2020

Ombrato L and Montagner M
Frontiers in Oncology, Frontiers Media vol. 10, 594514-594514.
04-11-2020
2019

Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee J-H and Malanchi I
Nature, Springer Nature vol. 575 (7784), e8-e8.
01-11-2019

Ombrato L, Nolan E, Kurelac I, Mavousian A, Bridgeman VL, Heinze I, Chakravarty P, Horswell S, Gonzalez-Gualda E, Matacchione G, Weston A, Kirkpatrick J, Husain E, Speirs V, Collinson L, Ori A, Lee J-H and Malanchi I
Nature, Springer Nature vol. 572 (7771), 603-608.
28-08-2019

Ombrato L and Malanchi I
Nature Cell Biology, Springer Nature vol. 21 (7), 797-798.
01-07-2019

Kurelac I, Iommarini L, Vatrinet R, Amato LB, De Luise M, Leone G, Girolimetti G, Umesh Ganesh N, Bridgeman VL, Ombrato L, Columbaro M, Ragazzi M, Gibellini L, Sollazzo M, Feichtinger RG, Vidali S, Baldassarre M, Foriel S, Vidone M, Cossarizza A, Grifoni D, Kofler B, Malanchi I, Porcelli AM and Gasparre G
Nature Communications, Springer Nature vol. 10 (1)
22-02-2019
2015

del Pozo Martin Y, Park D, Ramachandran A, Ombrato L, Calvo F, Chakravarty P, Spencer-Dene B, Derzsi S, Hill CS, Sahai E and Malanchi I
Cell Reports, Elsevier vol. 13 (11), 2456-2469.
01-12-2015
2014

Aulicino F, Theka I, Ombrato L, Lluis F and Cosma MP
Stem Cell Reports, Elsevier vol. 2 (5), 707-720.
01-05-2014

Ombrato L and Malanchi I
Critical Reviews™ in Oncogenesis, Begell House vol. 19 (5), 349-361.
01-01-2014
2012

Ombrato L, Lluis F and Cosma MP
Cell Cycle, Taylor & Francis vol. 11 (1), 39-47.
01-01-2012
2011

Lluis F, Ombrato L, Pedone E, Pepe S, Merrill BJ and Cosma MP
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 108 (29), 11912-11917.
05-07-2011
2007

Buccigrossi V, de Marco G, Bruzzese E, Ombrato L, Bracale I, Polito G and Guarino A
Pediatric Research, Springer Nature vol. 61 (4), 410-414.
01-04-2007
Grants

Luigi Ombrato
£744,164 CR-UK Cancer Research UK
01-10-2024 - 30-09-2030

Luigi Ombrato
£74,695 Barts and the London Charity
08-04-2024 - 07-04-2025

Luigi Ombrato and Oliver Pearce
£232,790 Innovate UK
30-08-2023 - 29-08-2025

Luigi Ombrato
£99,997 AMS Academy of Medical Sciences
01-03-2022 - 31-07-2025

Luigi Ombrato
£20,000 Royal Society
21-03-2022 - 20-09-2023

Luigi Ombrato
£49,047 RE Research England
01-09-2021 - 31-05-2022

Luigi Ombrato
£50,000 Bowel Research UK ( formerly Bowel & Cancer Research)
01-09-2021 - 09-01-2024