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Dr Li Chan

Li Chan

Clinical Senior Lecturer

Centre for Endocrinology
Queen Mary University of London

www.qmul.ac.uk/whri/people/academic-staff/items/chanli.html

Research

Interests

I am a Clinical Senior Lecturer/Honorary Consultant Paediatric Endocrinology at QMUL. My research is in the area of adrenal and metabolic dysfunction and as such I work on in-vitro and in-vivo models for these.

Publications of specific relevance to Predictive in vitro Models

Publications

2019

Novoselova TV, King PJ, Guasti L, Metherell LA, Clark AJL and Chan LF (2019). ACTH signalling and adrenal development: Lessons from mouse models. Endocrine Connections  vol. 8, (7) R122-R130. 10.1530/EC-19-0190
Maharaj A, Maudhoo A, Chan LF, Novoselova T, Prasad R, Metherell LA and Guasti L (2019). Isolated glucocorticoid deficiency: Genetic causes and animal models. Journal of Steroid Biochemistry and Molecular Biology  vol. 189, 73-80. 10.1016/j.jsbmb.2019.02.012
Clark AJL and Chan L (2019). Stability and Turnover of the ACTH Receptor Complex. Front Endocrinol (Lausanne)  vol. 10, 10.3389/fendo.2019.00491

2018

Novoselova TV, Hussain M, King PJ, Guasti L, Metherell LA, Charalambous M, Clark AJL and Chan LF (2018). MRAP deficiency impairs adrenal progenitor cell differentiation and gland zonation. Faseb Journal  vol. 32, (11) 6186-6196. 10.1096/fj.201701274RR
Novoselova TV, Chan LF and Clark AJL (2018). Pathophysiology of melanocortin receptors and their accessory proteins. Best Pract Res Clin Endocrinol Metab  vol. 32, (2) 93-106. 10.1016/j.beem.2018.02.002

2017

Clark AJL and Chan LF (2017). Promiscuity among the MRAPs. Bioscientifica  Journal of Molecular Endocrinology  vol. 58, (3) F1-F4. 10.1530/JME-17-0002

2016

Clark AJ, Forfar R, Hussain M, Jerman J, McIver E, Taylor D and Chan L (2016). ACTH Antagonists. Frontiers Media  Frontiers in Endocrinology  vol. 7, 10.3389/fendo.2016.00101

2015

Novoselova TV, Rath SR, Carpenter K, Pachter N, Dickinson JE, Price G, Chan LF, Choong CS and Metherell LA (2015). NNT Pseudoexon Activation as a Novel Mechanism for Disease in Two Siblings With Familial Glucocorticoid Deficiency. Endocrine Society  Journal of Clinical Endocrinology & Metabolism  vol. 100, (2) E350-E354. 10.1210/jc.2014-3641
Jackson DS, Ramachandrappa S, Clark AJ and Chan LF (2015). Melanocortin receptor accessory proteins in adrenal disease and obesity. Frontiers in Neuroscience  vol. 9, (MAY) 10.3389/fnins.2015.00213
Chan LF, Campbell DC, Novoselova TV, Clark AJL and Metherell LA (2015). Whole-Exome Sequencing in the Differential Diagnosis of Primary Adrenal Insufficiency in Children. Front Endocrinol (Lausanne)  vol. 6, 10.3389/fendo.2015.00113

2014

Prasad R, Chan LF, Hughes CR, Kaski JP, Kowalczyk JC, Savage MO, Peters CJ, Nathwani N, Clark AJL, Storr HL and Metherell LA (2014). Thioredoxin Reductase 2 (TXNRD2) mutation associated with familial glucocorticoid deficiency (FGD). J Clin Endocrinol Metab  vol. 99, (8) E1556-E1563. 10.1210/jc.2013-3844
(2014). Melanocortin 2 Receptor Accessory Protein 2 (Mrap2) Regulates Hypothalamic Melanocortin-4-Receptor Trafficking in Vivo. Endocrine Reviews  vol. 35, (3)

2013

Asai M, Ramachandrappa S, Joachim M, Shen Y, Zhang R, Nuthalapati N, Ramanathan V, Strochlic DE, Ferket P, Linhart K, Ho C, Novoselova TV, Garg S, Ridderstråle M, Marcus C, Hirschhorn JN, Keogh JM, ORahilly S, CHAN L, Clark AJ, Farooqi IS and Majzoub JA (2013). Loss of Function of the Melanocortin 2 Receptor Accessory Protein 2 Is Associated with Mammalian Obesity. American Association For The Advancement of Science  Science  vol. 341, (6143) 275-278. 10.1126/science.1233000
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Mol Cell Endocrinol  vol. 371, (1-2) 195-200. 10.1016/j.mce.2012.12.010
Meimaridou E, Hughes CR, Kowalczyk J, Guasti L, Chapple JP, King PJ, Chan LF, Clark AJL and Metherell LA (2013). Familial glucocorticoid deficiency: New genes and mechanisms. Molecular and Cellular Endocrinology  vol. 371, (1-2) 195-200. 10.1016/j.mce.2012.12.010
Novoselova TV, Jackson D, Campbell DC, Clark AJL and Chan LF (2013). Melanocortin receptor accessory proteins in adrenal gland physiology and beyond. J Endocrinol  vol. 217, (1) R1-11. 10.1530/JOE-12-0501
Meimaridou E, Hughes CR, Kowalczyk J, Chan LF, Clark AJL and Metherell LA (2013). ACTH resistance: genes and mechanisms. Endocr Dev  vol. 24, 57-66. 10.1159/000342504
Ramachandrappa S, Gorrigan RJ, Clark AJL and Chan LF (2013). The melanocortin receptors and their accessory proteins. Front Endocrinol (Lausanne)  vol. 4, 10.3389/fendo.2013.00009
(2013). Loss of function of the melanocortin 2 receptor accessory protein 2 is associated with mammalian obesity. Science  vol. 341, (6143) 275-278. 10.1126/science.1233000

2011

Jain V, Metherell LA, David A, Sharma R, Sharma PK, Clark AJL and Chan LF (2011). Neonatal presentation of familial glucocorticoid deficiency resulting from a novel splice mutation in the melanocortin 2 receptor accessory protein. Eur J Endocrinol  vol. 165, (6) 987-991. 10.1530/EJE-11-0581
Chan LF, Metherell LA and Clark AJL (2011). Effects of melanocortins on adrenal gland physiology. Eur J Pharmacol  vol. 660, (1) 171-180. 10.1016/j.ejphar.2010.11.041
Gorrigan RJ, Guasti L, King P, Clark AJ and Chan LF (2011). Localisation of the melanocortin-2-receptor and its accessory proteins in the developing and adult adrenal gland. J Mol Endocrinol  vol. 46, (3) 227-232. 10.1530/JME-11-0011
Chan LF, Vaidya M, Westphal B, Allgrove J, Martin L, Afshar F, Hindmarsh PC, Savage MO, Grossman AB and Storr HL (2011). Use of intravenous etomidate to control acute psychosis induced by the hypercortisolaemia in severe paediatric Cushing's disease. Horm Res Paediatr  vol. 75, (6) 441-446. 10.1159/000324419

2010

Chan L, Albertsson-Wikland K, Camacho-Hübner C and Hochberg Z (2010). Signal transduction in child health: closing the gap between clinical and basic research. Sci Signal  vol. 3, (143) 10.1126/scisignal.3143mr3
Chung T-TLL, Chan LF, Metherell LA and Clark AJL (2010). Phenotypic characteristics of familial glucocorticoid deficiency (FGD) type 1 and 2. Clin Endocrinol (Oxf)  vol. 72, (5) 589-594. 10.1111/j.1365-2265.2009.03663.x
Dias RP, Kumaran A, Chan LF, Martin L, Afshar F, Matson M, Plowman PN, Monson JP, Besser GM, Grossman AB, Savage MO and Storr HL (2010). Diagnosis, management and therapeutic outcome in prepubertal Cushing's disease. Eur J Endocrinol  vol. 162, (3) 603-609. 10.1530/EJE-09-0509
Dias RP, Chan LF, Metherell LA, Pearce SHS and Clark AJL (2010). Isolated Addison's disease is unlikely to be caused by mutations in MC2R, MRAP or STAR, three genes responsible for familial glucocorticoid deficiency. Eur J Endocrinol  vol. 162, (2) 357-359. 10.1530/EJE-09-0720
Savage MO, Dias RP, Chan LF, Afshar F, Plowman PN, Matson M, Grossman AB and STORR HL (2010). Diagnosis and Treatment of Cushing’s Disease in Children. Pediatric Neuroendocrinology , Editors: Loche S, Cappa M, Ghizzoni L, Maghnie M and Savage MO. Karger Publishers  10.1159/000262535
Savage MO, Dias RP, Chan LF, Afshar F, Plowman NP, Matson M, Grossman AB and Storr HL (2010). Diagnosis and treatment of Cushing's disease in children. Endocr Dev  vol. 17, 134-145. 10.1159/000262535

2009

(2009). Homozygous nonsense and frameshift mutations of the ACTH receptor in children with familial glucocorticoid deficiency (FGD) are not associated with long-term mineralocorticoid deficiency. Clin Endocrinol (Oxf)  vol. 71, (2) 171-175. 10.1111/j.1365-2265.2008.03511.x
Chan LF, Webb TR, Chung T-T, Meimaridou E, Cooray SN, Guasti L, Chapple JP, Egertová M, Elphick MR, Cheetham ME, Metherell LA and Clark AJL (2009). MRAP and MRAP2 are bidirectional regulators of the melanocortin receptor family. Proc Natl Acad Sci U S A  vol. 106, (15) 6146-6151. 10.1073/pnas.0809918106
Chan LF, Chung T-T, Massoud AF, Metherell LA and Clark AJL (2009). Functional consequence of a novel Y129C mutation in a patient with two contradictory melanocortin-2-receptor mutations. Eur J Endocrinol  vol. 160, (4) 705-710. 10.1530/EJE-08-0636
Clark AJL, Chan LF, Chung T-T and Metherell LA (2009). The genetics of familial glucocorticoid deficiency. Best Pract Res Clin Endocrinol Metab  vol. 23, (2) 159-165. 10.1016/j.beem.2008.09.006
Cooray SN, Chan L, Webb TR, Metherell L and Clark AJL (2009). Accessory proteins are vital for the functional expression of certain G protein-coupled receptors. Mol Cell Endocrinol  vol. 300, (1-2) 17-24. 10.1016/j.mce.2008.10.004
Webb TR, Chan L, Cooray SN, Cheetham ME, Chapple JP and Clark AJL (2009). Distinct melanocortin 2 receptor accessory protein domains are required for melanocortin 2 receptor interaction and promotion of receptor trafficking. Endocrinology  vol. 150, (2) 720-726. 10.1210/en.2008-0941
Metherell LA, Chung TT, Chan LF and Clark AJL (2009). Genotype:phenotype relationships in familial glucocorticoid deficiency types 1 and 2. Horm Res  vol. 72, 211-211.
Chan LF, David A, Jain V, Clark AJL and Metherell LA (2009). A novel splice mutation (IVSds3+3insTA) in the melanocortin 2 receptor accessory protein that leads to skipping of exon 3. Horm Res  vol. 72, 70-70.
Dias RP, Kumaran A, Chan LF, Martin L, Afshar F, Matson M, Plowman PN, Monson JP, Besser GM, Grossman AB, Savage MO and Storr HL (2009). Prepubertal Cushing's disease: diagnosis, management and therapeutic outcome. Hormone Research  vol. 72, 72-72.
(2009). Homozygous nonsense and frameshift mutations of the ACTH receptor in children with familial glucocorticoid deficiency (FGD) are not associated with long-term mineralocorticoid deficiency. Clin Endocrinol (Oxf)  vol. 71, (2) 171-175. 10.1111/j.1365-2265.2008.03511.x

2008

Chung TT, Webb TR, Chan LF, Cooray SN, Metherell LA, King PJ, Chapple JP and Clark AJL (2008). The majority of adrenocorticotropin receptor (melanocortin 2 receptor) mutations found in familial glucocorticoid deficiency type 1 lead to defective trafficking of the receptor to the cell surface. J Clin Endocrinol Metab  vol. 93, (12) 4948-4954. 10.1210/jc.2008-1744
Savage MO, Chan LF, Grossman AB and Storr HL (2008). Work-up and management of paediatric Cushing's syndrome. Curr Opin Endocrinol Diabetes Obes  vol. 15, (4) 346-351. 10.1097/MED.0b013e328305082f
(2008). A novel variant of familial glucocorticoid deficiency prevalent among the Irish traveler population. J Clin Endocr Metab  vol. 93, (7) 2896-2899. 10.1210/jc.2008-0034
(2008). A novel variant of familial glucorticoid deficiency prevalent among the Irish traveler population. J Clin Endocrinol Metab.  vol. 93, (7) 2896-2899. 10.1210/jc.2008-0034
Chan LF, Clark AJL and Metherell LA (2008). Familial glucocorticoid deficiency: advances in the molecular understanding of ACTH action. Horm Res  vol. 69, (2) 75-82. 10.1159/000111810
Cooray SN, Chan L, Metherell L, Storr H and Clark AJL (2008). Adrenocorticotropin resistance syndromes. Endocr Dev  vol. 13, 99-116. 10.1159/000134828
Storr H, Alexandraki K, Chan L, Martin L, Monson J, Besser M, Grossman A and Savage M (2008). Comparisons in the epidemiology and diagnostic features between paediatric and adult Cushing's disease. Horm Res  vol. 70, 24-25.
Chan L, Chung TT, Massoud A, Metherell L and Clark A (2008). Functional consequence of two opposing MC2R mutations in a child with severe FGD phenotype. Horm Res  vol. 70, 23-23.
Savage MO, Chan LF, Afshar F, Plowman PN, Grossman AB and Storr HL (2008). Advances in the management of paediatric Cushing's disease. Horm Res  vol. 69, (6) 327-333. 10.1159/000117388

2007

Chan LF, Storr HL, Grossman AB and Savage MO (2007). Pediatric Cushing's syndrome: clinical features, diagnosis, and treatment. Arq Bras Endocrinol Metabol  vol. 51, (8) 1261-1271. 10.1590/s0004-27302007000800012
Storr HL, Chan LF, Grossman AB and Savage MO (2007). Paediatric Cushing's syndrome: epidemiology, investigation and therapeutic advances. Trends Endocrin Met  vol. 18, (4) 167-174. 10.1016/j.tem.2007.03.006
Chan LF, Storr HL, Plowman PN, Perry LA, Besser GM, Grossman AB and Savage MO (2007). Long-term anterior pituitary function in patients with paediatric Cushing's disease treated with pituitary radiotherapy. Eur J Endocrinol  vol. 156, (4) 477-482. 10.1530/EJE-06-0588
Savage MO, Storr HL, Chan LF and Grossman AB (2007). Diagnosis and treatment of pediatric Cushing's disease. Pituitary  vol. 10, (4) 365-371. 10.1007/s11102-007-0056-4

2006

Metherell LA, Chan LF and Clark AJL (2006). The genetics of ACTH resistance syndromes. Best Pract Res Clin Endocrinol Metab  vol. 20, (4) 547-560. 10.1016/j.beem.2006.09.002
Chan L, Storr H, Plowman PN, Perry L, Monson J, Besser GM, Grossman A and Savage M (2006). Anterior pituitary function in the long-term follow-up of five paediatric Cushing's disease patients treated with pituitary radiotherapy. Horm Res  vol. 65, 186-186.

2004

Chan LF, Storr HL, Scheimberg I, Perry LA, Banerjee K, Miraki-Moud F, Camacho-Hubner C and Savage MO (2004). Pseudo-precocious puberty caused by a juvenile granulosa cell tumor secreting androstenedione, inhibin and insulin-like growth factor-I. J Pediatr Endocr Met  vol. 17, (4) 679-684. 10.1515/jpem.2004.17.4.679
Chan L and Hodes D (2004). When is an abnormal frenulum a sign of child abuse? Arch Dis Child  vol. 89, (3)

Grants

Grants of specific relevance to Predictive in vitro Models
Improved genetic diagnosis of primary adrenal insufficiency
Storr HL, Metherell LA and Chan L
£500,199 Barts Charity (01-08-2018 - 31-07-2022)
The role of MRAPs in the control of melanocortin receptor dependent energy homeostasis and adrenal function
Chan LF
£1,025,346 Medical Research Council (04-01-2010 - 07-08-2017)
Abstract