Prof John Marshall

John Marshall

Professor and Lead, Centre for Tumour Biology

FMD
Barts Cancer Institute
www.bartscancer.london/staff/professor-john-f-marshall/

Research

Cancer, Metastasis, Adhesion, Integrin, Translational, Spheroids, Organoids

Interests

1.Developed and use organotypic 3D multi-cellular invasion models in vitro and in vivo
2.Use 3D spheroid invasion models
3.Interest in introducing immune cells into tumour-stomal assays

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2026

Comparison of the in vivo biodistributions of αvβ6 binding agents for PET imaging applications
Swift EA, Paisey SJ, Phesse TJ, Marshall JF, Parker AL, Bayliss RJ
Molecular Therapy Oncology, Elsevier 
01-05-2026
Unveiling a Novel Molecular Interaction and Pro-Metastatic Signaling Cascades Driven by KRIT1
Paradisi L, Guazzi P, Macis M, Finetti F, Trezza A, De Paolo R, Roncetti M, Marshall JF et al.
International Journal of Molecular Sciences, Mdpi vol. 27 (8) 
10-04-2026
Transdermal Estradiol Patches in Locally Advanced Prostate Cancer
Langley RE, Gilbert DC, Mangar S, Rosen S, Bourmaki E, Rush HL, Kananga Sundaram S, Alhasso A et al.
The New England Journal of Medicine, Massachusetts Medical Society vol. 394 (16), 1595-1607.  
25-03-2026
Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer
Laforêts F, Kotantaki P, Elorbany S, Hartlebury J, Joy JD, Malacrida B, Bryan-Ravenscroft RC, Berlato C et al.
Iscience, Elsevier vol. 29 (3) 
09-02-2026
O15 Improving skin regeneration in JEB by targeting the integrin αvβ6
Lapinska V, Ferguson C, Marshall J, Caley M, Rognoni E
British Journal of Dermatology, Oxford University Press (Oup) vol. 194 (1) 
06-01-2026

2025

Repurposing of disulfiram as a novel therapeutic agent to treat crebbp-mutant diffuse large B-cell lymphoma (DLBCL)
Boncan J, Dimitrova L, Choudhury P, Rajput L, Sateri K, Maniati E, Wang J, Marshall J et al.
Blood, American Society of Hematology vol. 146 (Supplement 1), 1524-1524.  
03-11-2025
Multivalent DNA Origami Enables Single-Molecule Dissection of Integrin αvβ6–Receptor Tyrosine Kinase Crosstalk in Cancer Biology
Zheng T, Rigby LG, Marshall JF, Palma M
Acs Nano, American Chemical Society (Acs) vol. 19 (35), 31467-31480.  
26-08-2025
The Combination of Oncolytic Virus and Antibody Blockade of TGF-β Enhances the Efficacy of αvβ6-Targeting CAR T Cells Against Pancreatic Cancer in an Immunocompetent Model
Zhao Z, Cutmore LC, Baleeiro RB, Hartlebury JJ, Brown N, Chard-Dunmall L, Lemoine N, Wang Y et al.
Cancers, Mdpi vol. 17 (9) 
30-04-2025
Abstract 3859: Ephrin inhibition disrupts stromal-cancer crosstalk and reduces metastasis in pancreatic cancer
Bolton CL, O'Sullivan R, Menezes S, Cameron AJ, Marin G, Marshall JF, Carter EP, Henkemeyer M et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 85 (8_Supplement_1), 3859-3859.  
21-04-2025
Use of metabolic imaging to monitor heterogeneity of tumour response following therapeutic mTORC1/2 pathway inhibition
Ling S, Dexter A, Race AM, Sharma S, Hamm G, Polanska UM, UK RCCR, Marshall JF et al.
Disease Models & Mechanisms, The Company of Biologists vol. 18 (2) 
01-02-2025
Visualizing Cancer Heterogeneity at the Molecular and Cellular Levels: Lessons from Rosetta.
Goodwin RJA, Marshall JF, Poulogiannis G, Yuneva M, Brindle KM, Takáts Z, Sansom OJ, Bunch J et al.
Cancer Discovery, American Association For Cancer Research (Aacr) vol. 15 (1), 34-38.  
13-01-2025

2024

A trafficking regulatory subnetwork governs αVβ6 integrin-HER2 cross-talk to control breast cancer invasion and drug resistance
Maldonado H, Dreger M, Bedgood LD, Kyriakou T, Wolanska KI, Rigby ME, Marotta VE, Webster JM et al.
Science Advances, American Association For The Advancement of Science (Aaas) vol. 10 (49) 
04-12-2024
Syngeneic Mouse Models for Pre-Clinical Evaluation of CAR T Cells
Ahmed EN, Cutmore LC, Marshall JF
Cancers, Mdpi vol. 16 (18) 
18-09-2024
Integrin-αvβ6 targeted peptide-toxin therapy in a novel αvβ6-expressing immunocompetent model of pancreatic cancer
Brown NF, Murray ER, Cutmore LC, Howard P, Masterson L, Zammarchi F, Hartley JA, van Berkel PH et al.
Pancreatology, Elsevier vol. 24 (3), 445-455.  
24-02-2024
Understanding Predictors of Crohn’s Disease: Determinants of Altered Barrier Function in Pre-Disease Phase of Crohn’s Disease
Neustaeter A, Leibovitzh H, Turpin W, Croitoru K, Abreu M, Beck P, Bernstein C, Croitoru K et al.
Journal of The Canadian Association of Gastroenterology, Oxford University Press (Oup) vol. 7 (1), 68-77.  
20-01-2024
Selective placement of functionalised DNA origami via thermal scanning probe lithography patterning
Zheng T, O’Neill C, Marshall JF, Iskratsch T, Palma M
Materials Advances, Royal Society of Chemistry (Rsc) vol. 5 (23), 9376-9382.  
01-01-2024

2023

53P Integrin-αvβ6 targeted CAR T cells in an immunocompetent orthotopic model of pancreatic cancer
Brown NF, Cutmore L, Murray E, Marshall JF
Immuno-Oncology Technology, Elsevier vol. 20 
01-12-2023
TGFβ-mediated MMP13 secretion drives myoepithelial cell dependent breast cancer progression
Gibson SV, Tomas Bort E, Rodríguez-Fernández L, Allen MD, Gomm JJ, Goulding I, auf dem Keller U, Agnoletto A et al.
Npj Breast Cancer, Springer Nature vol. 9 (1) 
02-03-2023
Anti-Integrin αvβ6 Autoantibodies Are a Novel Biomarker That Antedate Ulcerative Colitis
Livanos AE, Dunn A, Fischer J, Ungaro RC, Turpin W, Lee S-H, Rui S, Del Valle DM et al.
Gastroenterology, Elsevier vol. 164 (4), 619-629.  
10-01-2023
αv Integrin-Dependent TGFβ Activation in Cancer: A Brief Update
Marshall JF, Protopapa P, Allen N
In Integrins in Health and Disease, Springer Nature 217-232.  
01-01-2023

2022

Mechanostimulation of breast myoepithelial cells induces functional changes associated with DCIS progression to invasion
Hayward M-K, Allen MD, Gomm JJ, Goulding I, Thompson CL, Knight MM, Marshall JF, Jones JL
Npj Breast Cancer, Springer Nature vol. 8 (1) 
20-09-2022
Ligand-bound integrin αvβ6 internalisation and trafficking
Meecham A, Cutmore LC, Protopapa P, Rigby LG, Marshall JF
Frontiers in Cell and Developmental Biology, Frontiers vol. 10 
24-08-2022
Synthesis and Systematic Study on the Effect of Different PEG Units on Stability of PEGylated, Integrin-αvβ6-Specific A20FMDV2 Analogues in Rat Serum and Human Plasma
Hung K-Y, Kowalczyk R, Desai A, Brimble MA, Marshall JF, Harris PWR
Molecules, Mdpi vol. 27 (14) 
06-07-2022
Disruption of pancreatic stellate cell myofibroblast phenotype promotes pancreatic tumor invasion
Murray ER, Menezes S, Henry JC, Williams JL, Alba-Castellón L, Baskaran P, Quétier I, Desai A et al.
Cell Reports, Elsevier vol. 38 (4) 
01-01-2022
Optimisation of αvβ6-specific peptides for use in targeted radionuclide therapy
Kashani R, Khan N, Foster J, Young J, Marshall J, Sosabowski JK
 
01-01-2022

2021

Abstract 958: Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin αvβ6-targeting peptide-drug conjugate
Murray ER, Brown NF, Howard P, Masterson L, Zammarchi F, van Berkel PH, Marshall JF
Cancer Research, American Association For Cancer Research (Aacr) vol. 81 (13_Supplement), 958-958.  
01-07-2021
Current Perspectives on the Use of off the Shelf CAR-T/NK Cells for the Treatment of Cancer
Cutmore LC, Marshall JF
Cancers, Mdpi vol. 13 (8) 
16-04-2021
CEACAM7 Is an Effective Target for CAR T-cell Therapy of Pancreatic Ductal Adenocarcinoma
Raj D, Nikolaidi M, Garces I, Lorizio D, Castro NM, Caiafa SG, Moore K, Brown NF et al.
Clinical Cancer Research, American Association For Cancer Research (Aacr) vol. 27 (5), 1538-1552.  
01-03-2021
Harnessing the power of foot-and-mouth-disease virus for targeting integrin alpha-v beta-6 for the therapy of cancer
Meecham A, Marshall J
Expert Opinion On Drug Discovery, Taylor & Francis vol. 16 (7), 737-744.  
03-02-2021
The amino acid transporter SLC7A5 is required for efficient growth of KRAS-mutant colorectal cancer
Najumudeen AK, Ceteci F, Fey SK, Hamm G, Steven RT, Hall H, Nikula CJ, Dexter A et al.
Nature Genetics, Springer Nature vol. 53 (1), 16-26.  
01-01-2021
Relationship between altered myoepithelial phenotype and the inflammatory cell infiltrate in progression of DCIS
Ohaida K, Allen M, Goom J, Marshall J, Jones L
 
01-01-2021
Effective targeting of pancreatic ductal adenocarcinoma metastases with an integrin avβ6-targeting peptide-drug conjugate.
Murray ER, Brown NF, Howard P, Masterson L, Zammarchi F, van Berkel PH, Marshall JF
 
01-01-2021

2020

Loss of the laminin subunit alpha‐3 induces cell invasion and macrophage infiltration in cutaneous squamous cell carcinoma*
Caley MP, Martins VL, Moore K, Lashari M, Nissinen L, Kähäri V, Alexander S, Jones E et al.
British Journal of Dermatology, Oxford University Press (Oup) vol. 184 (5), 923-934.  
01-12-2020
Switchable CAR-T cells mediate long-term remission of PDAC
Raj D, Marshall J, Young TS, Aicher A, Heeschen C
Pancreatology, Elsevier vol. 20 (8) 
01-12-2020
VAR2CSA-based CAR-T cells for the treatment of pancreatic ductal adenocarcinoma
Cutmore L, Cornish D, Brown N, Nikolaidi M, Raj D, Heeschen C, Marshall J
Pancreatology, Elsevier vol. 20 (8), e6-e7.  
01-12-2020
αvβ6 targeted CAR-T cells in immunocompetent orthotopic murine PDAC
Brown N, Nikolaidi M, Cutmore L, Cornish D, Raj D, Heeschen C, Marshall J
Pancreatology, Elsevier vol. 20 (8) 
01-12-2020
The ITGB6 gene: its role in experimental and clinical biology.
Meecham A, Marshall JF
Gene vol. 763S 
01-12-2020
Human and Murine CAR T cells for targeting integrin Alpha V Beta 6 in Pancreatic Ductal Adenocarcinoma
Cutmore L, Brown N, Marshall JF
Pancreatology, Elsevier vol. 20 (8) 
01-12-2020
Associations of NOD2 polymorphisms with Erysipelotrichaceae in stool of in healthy first degree relatives of Crohn’s disease subjects
Turpin W, Bedrani L, Espin-Garcia O, Xu W, Silverberg MS, Smith MI, Garay JAR, Lee S-H et al.
Bmc Medical Genomics, Springer Nature vol. 21 (1) 
15-10-2020
Epidermolysis bullosa
Bardhan A, Bruckner-Tuderman L, Chapple ILC, Fine J-D, Harper N, Has C, Magin TM, Marinkovich MP et al.
Nature Reviews Disease Primers, Springer Nature vol. 6 (1) 
24-09-2020
Simultaneous dual isotope PET-SPECT/CT imaging of pancreatic cancer
Dexter K, BROWN N, Foster J, Kashani R, CHUPIN J, Cleaver J, Cutmore L, Marshall J et al.
 
26-08-2020
Pancreatic Cancer UK Grand Challenge: Developments and challenges for effective CAR T cell therapy for pancreatic ductal adenocarcinoma
Cutmore LC, Brown NF, Raj D, Chauduri S, Wang P, Maher J, Wang Y, Lemoine NR et al.
Pancreatology, Elsevier vol. 20 (3), 394-408.  
15-02-2020
Integrin αvβ6-specific therapy for pancreatic cancer developed from foot-and-mouth-disease virus
Moore KM, Desai A, de Luxán Delgado B, Trabulo SMD, Reader C, Brown NF, Murray ER, Brentnall A et al.
Theranostics, Ivyspring International Publisher vol. 10 (7), 2930-2942.  
12-02-2020

2019

The ITGB6 gene: its role in experimental and clinical biology.
Meecham A, Marshall JF
Gene vol. 763S 
06-11-2019
Integrin-Mediated TGFβ Activation Modulates the Tumour Microenvironment
Brown NF, Marshall JF
Cancers, Mdpi vol. 11 (9) 
21-08-2019
The integrin αvβ6 drives pancreatic cancer through diverse mechanisms and represents an effective target for therapy
Reader CS, Vallath S, Steele CW, Haider S, Brentnall A, Desai A, Moore KM, Jamieson NB et al.
The Journal of Pathology, Wiley vol. 249 (3), 332-342.  
30-07-2019
Probing the nanoscale organisation and multivalency of cell surface receptors:\nDNA origami nanoarrays for cellular studies with single-molecule control
Hawkes W, HUANG D, Reynolds P, HAMMOND L, WARD M, Gadegaard N, MARSHALL J, ISKRATSCH T et al.
Faraday Discussions, Royal Society of Chemistry 
18-03-2019
A framework for the development of effective anti-metastatic agents.
Anderson RL, Balasas T, Callaghan J, Coombes RC, Evans J, Hall JA, Kinrade S, Jones D et al.
Nat Rev Clin Oncol vol. 16 (3), 185-204.  
01-03-2019
Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
Thomas JR, Moore KM, Sproat C, Mo S, Wolanska KI, Maldonado H, Haider S, Newman D et al.
 
01-01-2019

2018

DNA Origami Nanoarrays for Multivalent Investigations of Cancer Cell Spreading with Nanoscale Spatial Resolution and Single-Molecule Control
Huang D, Patel K, Perez-Garrido S, Marshall JF, Palma M
Acs Nano, American Chemical Society (Acs) vol. 13 (1), 728-736.  
27-12-2018
P1.03-19 Antibody Blockade of Integrin Alpha-V-Beta-6 (avb6) as a Novel Treatment for NSCLC
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J
 
01-10-2018
The Novel Oncolytic Adenoviral Mutant Ad5-3Δ-A20T Retargeted to αvβ6 Integrins Efficiently Eliminates Pancreatic Cancer Cells
Man YKS, Davies JA, Coughlan L, Pantelidou C, Blázquez-Moreno A, Marshall JF, Parker AL, Halldén G
Molecular Cancer Therapeutics, American Association For Cancer Research (Aacr) vol. 17 (2), 575-587.  
01-02-2018
PHLDA1 Mediates Drug Resistance in Receptor Tyrosine Kinase-Driven Cancer
Fearon AE, Carter EP, Clayton NS, Wilkes EH, Baker A-M, Kapitonova E, Bakhouche BA, Tanner Y et al.
Cell Reports, Elsevier vol. 22 (9), 2469-2481.  
01-02-2018
Targeting CDH17 in Cancer: When Blocking the Ligand Beats Blocking the Receptor?
Marshall JF
Clinical Cancer Research, American Association For Cancer Research (Aacr) vol. 24 (2), 253-255.  
15-01-2018
Correlative 3D Structured Illumination Microscopy and Single-Molecule Localization Microscopy for Imaging Cancer Invasion.
Pinnington SJL, Marshall JF, Wheeler AP
Methods Mol Biol vol. 1764, 253-265.  
01-01-2018
Loss of Lamα3 drives M2 macrophage differentiation in squamous cell carcinoma
Caley M, Martins V, Moore K, Lashari M, Marshall J, O'Toole E
 
01-01-2018
Blockade of integrin alpha-v-beta-6 (αvβ6) reduces the invasive potential of NSCLC
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J
 
01-01-2018
12 Blockade of integrin alpha-v-beta-6 (αvβ6) reduces the invasive potential of NSCLC
Rudran B, Reader C, Foster J, Hodivala-Dilke K, Sosabowski J, Marshall J
Lung Cancer, Elsevier vol. 115, s5-s6.  
01-01-2018

2017

The novel oncolytic adenoviral mutant Ad5-3 Delta-A20T retargeted to alpha v beta 6-integrins efficiently eliminates pancreatic cancer cells
Man YKS, Davies JA, Coughlan L, Pantelidou C, Marshall JF, Parker AL, Hallden G
IAM Mexico. 
01-12-2017
336 Tumour associated macrophage recruitment in SCC
Caley M, Martins V, Moore K, Lashari M, Marshall J, O’Toole EA
 
01-10-2017
Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al.
Molecular Therapy, Elsevier Bv vol. 25 (10), 2427-2427.  
01-10-2017
Myoepithelial Cell Phenotype in DCIS Progression: Functional Significance of Integrin alpha v beta 6 and Fibronectin
Hayward M, Allen MD, Gomm JJ, Haywood L, Marshall JF, Jones LJ
Belfast Pathology 2017 20 Jun 2017 - 23 Jun 2017. 
01-09-2017
Integrins as Therapeutic Targets: Successes and Cancers
Raab-Westphal S, Marshall JF, Goodman SL
Cancers, Mdpi vol. 9 (9) 
23-08-2017
Pro‐migratory and TGF‐β‐activating functions of αvβ6 integrin in pancreatic cancer are differentially regulated via an Eps8‐dependent GTPase switch
Tod J, Hanley CJ, Morgan MR, Rucka M, Mellows T, Lopez M, Kiely P, Moutasim KA et al.
The Journal of Pathology, Wiley vol. 243 (1), 37-50.  
07-08-2017
Structure-activity relationship study of the tumour-targeting peptide A20FMDV2 via modification of Lys16, Leu13, and N- and/or C-terminal functionality
Hung K-Y, Harris PWR, Desai A, Marshall JF, Brimble MA
European Journal of Medicinal Chemistry, Elsevier vol. 136, 154-164.  
03-05-2017
Investigating in vitro and in vivo αvβ6 integrin receptor-targeting liposomal alendronate for combinatory γδ T cell immunotherapy
Hodgins NO, Al-Jamal WT, Wang JT-W, Klippstein R, Costa PM, Sosabowski JK, Marshall JF, Maher J et al.
Journal of Controlled Release, Elsevier vol. 256, 141-152.  
18-04-2017
Loss of MMP-8 in ductal carcinoma in situ (DCIS)-associated myoepithelial cells contributes to tumour promotion through altered adhesive and proteolytic function
Sarper M, Allen MD, Gomm J, Haywood L, Decock J, Thirkettle S, Ustaoglu A, Sarker S-J et al.
Breast Cancer Research, Springer Nature vol. 19 (1) 
23-03-2017
Development of non-invasive imaging of integrin alpha-v-beta-6 (alpha v beta 6)-positive lung cancers in advance of testing alpha v beta 6-targeted therapies
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J
British Thoracic Oncology Group Conference 2017 Dublin, Ireland 25 Jan 2017 - 27 Jan 2017. 
31-01-2017
Targeting of Aberrant αvβ6 Integrin Expression in Solid Tumors Using Chimeric Antigen Receptor-Engineered T Cells
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic RMG, Kao YV, Saxena SA, Romain A et al.
Molecular Therapy, Elsevier vol. 25 (1), 259-273.  
01-01-2017
6: Development of non-invasive imaging of integrin alpha-v-beta-6 (αvβ6)-positive lung cancers in advance of testing αvβ6-targeted therapies
Rudran B, Desai A, Luzarraga M, Hodivala-Dilke K, Foster J, Sosabowski J, Marshall J
Lung Cancer, Elsevier vol. 103 
01-01-2017

2016

Abstract B53: The integrin αvβ6 is a promising therapeutic target for treating PDAC
Vallath S, Reader C, Morton J, Sansom O, Evans J, Biankin A, Barry ST, Kocher H et al.
 
14-12-2016
Abstract A18: The integrin αvβ6 regulates PDAC cell growth and stromal cell behavior
Reader CS, Morton JP, Sansom OJ, Marshall JF
Cancer Research, American Association For Cancer Research (Aacr) vol. 76 (24_Supplement), a18-a18.  
14-12-2016
Investigating the Functional Significance of Aberrant alpha v beta 6 and Fibronectin Expression in Myoepithelial Cells: Role in the Progression of DCIS?
Hayward M, Allen MD, Dreger S, Marshall JF, Jones JL
Nottingham Pathology 2016 28 Jun 2016 - 1 Jul 2016. 
01-10-2016
472 Loss of Laminin α3 drives SCC invasion via ROCK signalling
Caley M, Martins V, Moore K, Lashari M, Kähäri V, Nissinen L, Donaldson M, Marshall J et al.
 
01-09-2016
P112 Discovery of a Novel, High Affinity, Small Molecule αvβ6 Inhibitor for the Treatment of Idiopathic Pulmonary Fibrosis
Slack R, John A, Forty E, Mercer P, Graves R, Pun T, Vitulli G, Gower E et al.
Qjm, Oxford University Press (Oup) vol. 109 (suppl_1), s60-s60.  
01-09-2016
The role of integrins in TGFβ activation in the tumour stroma
Khan Z, Marshall JF
Cell and Tissue Research, Springer Nature vol. 365 (3), 657-673.  
12-08-2016
The integrin αvβ6 is a promising therapeutic target for treating PDAC
Marshall J, Vallath S, Reader C, Morton J, Sansom O, Evans TRJ, Biankin A, Kocher HM
Pancreatology, Elsevier vol. 16 (3) 
01-06-2016
Modifying oncolytic viral therapy for pancreatic cancer
Man YKS, Pantelidou C, Blázquez-Moreno A, Coughlan L, Marshall J, Kocher H, Halldén G
Pancreatology, Elsevier vol. 16 (3) 
01-06-2016
The role of Galectin-7 in normal and DCIS-associated myoepithelial cells: predicting progression of DCIS
Allen N, Allen M, Gomm J, Hayward L, Ahmed K, Marshall J, Jones L
European Journal of Surgical Oncology, Elsevier vol. 42 (5) 
01-05-2016
The fibronectin/α3β1 integrin axis serves as molecular basis for keratinocyte invasion induced by βHPV
Heuser S, Hufbauer M, Steiger J, Marshall J, Sterner-Kock A, Mauch C, Zigrino P, Akgül B
Oncogene, Springer Nature vol. 35 (34), 4529-4539.  
25-01-2016
Pharmacological Characterization of the αvβ6 Integrin Binding and Internalization Kinetics of the Foot-and-Mouth Disease Virus Derived Peptide A20FMDV2
Slack RJ, Hafeji M, Rogers R, Ludbrook SB, Marshall JF, Flint DJ, Pyne S, Denyer JC
Pharmacology, Karger Publishers vol. 97 (3-4), 114-125.  
01-01-2016
ROCK and Rac1 signalling in squamous cell carcinoma with loss of laminin 332
Caley M, Martins V, Moore K, Lashari M, Donaldson M, Marshall JF, O'Toole EA
 
01-01-2016
Abstract B129: Chimeric antigen receptor T-cells targeting the αvβ6 integrin demonstrate potent antitumor activity in multiple solid tumors
Whilding LM, Parente-Pereira AC, Zabinski T, Davies DM, Petrovic R, Violette S, Ghaem-Maghami S, Vallath S et al.
 
01-01-2016
Oncolytic adenoviral mutants deleted in the anti-apoptotic E1B19K gene sensitize pancreatic cancer cells to drug-induced DNA damage
Pantelidou C, Man YKS, Coughlan L, Marshall J, Kocher H, Hallden G
International Journal of Molecular Medicine vol. 38, S58-S58.  
01-01-2016
Single-molecule investigations via DNA nanostructures: A cell adhesion study
Huang D, Keseroglu K, Garrido S, Sapelkin A, Marshall J, Palma M
 
01-01-2016

2015

Suppression of TGFβ and Angiogenesis by Type VII Collagen in Cutaneous SCC
Martins VL, Caley MP, Moore K, Szentpetery Z, Marsh ST, Murrell DF, Kim MH, Avari M et al.
Journal of The National Cancer Institute, Oxford University Press (Oup) vol. 108 (1) 
16-10-2015
Abstract B87: Cell lines generated from PDAC transgenic mice reveal integrin αvβ6 modifies the invasive phenotype of pancreatic cancer
Reader CS, Vallath S, Morton J, Steele C, Kocher HM, Keyse SM, Sansom O, Marshall JF
 
30-06-2015
Hedgehog Inhibition Results in the Upregulation of Pro-Tumourigenic αvβ6 Integrin Expression and Function in Cancer
Moutasim KA, Mellows T, Marshall JF, Jenei V, Thomas GJ
Oral Surgery Oral Medicine Oral Pathology and Oral Radiology, Elsevier vol. 119 (3) 
01-03-2015
7: The integrin αvβ6: a new target for therapy in non-small cell lung cancer
Rudran B, Marshall JF
 
01-01-2015
Squamous Cell Carcinoma progression and Laminin 332
Caley M, Martins V, Marsh S, Moore K, Lashari M, Donaldson MJ, Marshall J, O'toole E
 
01-01-2015
Skin type VII collagen acts as a tumour suppressor by regulating TGFβ and angiogenesis
Martins V, Caley M, Moore K, Szentpetery Z, Marsh S, Murrell DF, Kaehaeri V, McGrath J et al.
 
01-01-2015
Targeted Radionuclide Therapy using high-LET particle emitter-labeled vectors against alpha-v-beta6-expressing cancers
Paillas S, Desai A, Quetier I, Marshall J, Pouget J, Sosabowski J
 
01-01-2015

2014

A multi-gene signature predicts outcome in patients with pancreatic ductal adenocarcinoma
Haider S, Wang J, Nagano A, Desai A, Arumugam P, Dumartin L, Fitzgibbon J, Hagemann T et al.
Genome Medicine, Springer Nature vol. 6 (12) 
03-12-2014
αvβ6 Expression in myoepithelial cells: a novel marker for predicting DCIS progression with therapeutic potential.
Allen MD, Marshall JF, Jones JL
Cancer Res vol. 74 (21), 5942-5947.  
01-11-2014
Therapeutic targeting of integrin αvβ6 in breast cancer.
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.
J Natl Cancer Inst vol. 106 (8) 
01-08-2014
Rigidity sensing and adaptation through regulation of integrin types.
Elosegui-Artola A, Bazellières E, Allen MD, Andreu I, Oria R, Sunyer R, Gomm JJ, Marshall JF et al.
Nat Mater vol. 13 (6), 631-637.  
01-06-2014
The integrin αvβ6 is a promising target for the therapy of PDAC: toward phase I trials
Vallath S, Scarpa A, Weinreb P, Violette S, Steele C, Morton J, Sansom O, Davies J et al.
Pancreatology, Elsevier vol. 14 (2) 
01-03-2014
Altered microenvironment promotes progression of preinvasive breast cancer: myoepithelial expression of αvβ6 integrin in DCIS identifies high-risk patients and predicts recurrence.
Allen MD, Thomas GJ, Clark S, Dawoud MM, Vallath S, Payne SJ, Gomm JJ, Dreger SA et al.
Clin Cancer Res vol. 20 (2), 344-357.  
15-01-2014
Diverse roles for laminin-332 subunits in squamous cell carcinoma
Caley M, Martins V, Moore K, Marshall J, O'Toole E
 
01-01-2014
Suppression of Hedgehog signalling promotes pro-tumourigenic integrin expression and function
Moutasim KA, Mellows T, Mellone M, Lopez M-A, Tod J, Kiely PC, Sapienza K, Greco A et al.
Journal of Pathology vol. 233 (2), 196-208.  
01-01-2014
Development of a novel approach for targeted delivery of siRNA to B lymphocytes with a potential application in cancer
Muhammad H, Taher T, Mullen L, Pastan I, Marshall J, Chernajovsky Y, Gould D, Mageed R
 
01-01-2014
Diverse roles for laminin 332 subunits in squamous cell carcinoma
Caley M, Martins V, Moore K, Marshall J, O'toole E
 
01-01-2014

2013

Abstract P4-15-01: Integrin avb6 is a therapeutic target for high-risk breast cancer and enhances trastuzumab efficacy
Moore K, Thomas G, Duffy S, Warwick J, Gabe R, Chou P, Ellis I, Green A et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 73 (24_Supplement) 
15-12-2013
Activated pancreatic stellate cells sequester CD8+ T cells to reduce their infiltration of the juxtatumoral compartment of pancreatic ductal adenocarcinoma.
Ene-Obong A, Clear AJ, Watt J, Wang J, Fatah R, Riches JC, Marshall JF, Chin-Aleong J et al.
Gastroenterology vol. 145 (5), 1121-1132.  
01-11-2013
Critical research gaps and translational priorities for the successful prevention and treatment of breast cancer
Eccles SA, Aboagye EO, Ali S, Anderson AS, Armes J, Berditchevski F, Blaydes JP, Brennan K et al.
Breast Cancer Research vol. 15 (5) 
01-10-2013
Abstract B046: Therapeutic targeting of integrin αvβ6 in high-risk breast cancer
Moore KM, Thomas GJ, Duffy SW, Warwick J, Gabe R, Chou P, Ellis IO, Green AR et al.
Molecular Cancer Research, American Association For Cancer Research (Aacr) vol. 11 (10_Supplement), b046-b046.  
01-10-2013
Frequent mutation of the major cartilage collagen gene COL2A1 in chondrosarcoma
Tarpey PS, Behjati S, Cooke SL, Van Loo P, Wedge DC, Pillay N, Marshall J, O'Meara S et al.
Nature Genetics, Springer Nature vol. 45 (8), 923-926.  
16-06-2013
Pre-Clinical Imaging of the v6 Integrin for Molecular Stratification of Idiopathic Pulmonary Fibrosis
John AE, Luckett JC, Tatler AL, Awais RO, Habgood A, Ludbrook S, Blanchard A, Perkins AC et al.
 
01-05-2013
Single-cell paired-end genome sequencing reveals structural variation per cell cycle
Voet T, Kumar P, Van Loo P, Cooke SL, Marshall J, Lin M-L, Esteki MZ, Van der Aa N et al.
Nucleic Acids Research, Oxford University Press (Oup) vol. 41 (12), 6119-6138.  
27-04-2013
MMP-8 Loss Contributes to Altered Myoepithelial Cell Function in DCIS
Sarper M, Allen MD, Decock J, Thirkettle S, Edwards DR, Marshall JF, Jones LJ
 
01-01-2013
Diverse roles for laminin 332 subunits in squamous cell carcinoma
Caley MP, Martins V, Moore K, Marshall JF, O'Toole EA
 
01-01-2013
Loss of type VII collagen in cutaneous SCC increases angiogenesis
Martins VL, Caley MP, Moore K, Szentpetery Z, Murrell DF, Kim MH, McGrath JA, Cerio R et al.
 
01-01-2013
Structural guided scaffold phage display libraries as a source of bio-therapeutics.
Man YKS, DiCara D, Chan N, Vessillier S, Mather SJ, Rowe ML, Howard MJ, Marshall JF et al.
Plos One vol. 8 (8) 
01-01-2013
Generation and characterization of a diabody targeting the αvβ6 integrin.
Kogelberg H, Miranda E, Burnet J, Ellison D, Tolner B, Foster J, Picón C, Thomas GJ et al.
Plos One vol. 8 (9) 
01-01-2013
A human monoclonal antibody 264RAD targeting αvβ6 integrin reduces tumour growth and metastasis, and modulates key biomarkers in vivo
Eberlein C, Kendrew J, McDaid K, Alfred A, Kang JS, Jacobs VN, Ross SJ, Rooney C et al.
Oncogene vol. 32 (37), 4406-4416.  
01-01-2013
Preclinical SPECT/CT Imaging of αvβ6 Integrins for Molecular Stratification of Idiopathic Pulmonary Fibrosis
John AE, Luckett JC, Tatler AL, Awais RO, Desai A, Habgood A, Ludbrook S, Blanchard AD et al.
Journal of Nuclear Medicine vol. 54 (12), 2146-2152.  
01-01-2013
Formation and inhibition of invadopodia in oral squamous cell carcinoma
Ali I, Gautrot J, Caley M, Marshall JF, Wheeler A
 
01-01-2013
Rigidity sensing and adaptation through regulation of integrin populations
Elosegui-Artola A, Bazellieres E, Allen MD, Andreu I, Marshall JF, Jones JL, Trepat X, Roca-Cusachs P
Molecular Biology of The Cell vol. 24 
01-01-2013

2012

Abstract B42: Toward targeting integrin αvβ6 for the therapy of pancreatic cancer.
Vallath S, Gadaletta E, Chelala C, Scarpa A, Hart IR, Kocher HM, Marshall JF
Therapy. 
15-07-2012
16P Myoepithelial Control of the Inflammatory Microenvironment Promotes Transition of Dcis to Invasive Disease
Ahmed KO, Allen M, Gomm J, Marshall J, Jones JL
Annals of Oncology, Elsevier vol. 23 
01-05-2012
S100P-binding protein, S100PBP, mediates adhesion through regulation of cathepsin Z in pancreatic cancer cells.
Lines KE, Chelala C, Dmitrovic B, Wijesuriya N, Kocher HM, Marshall JF, Crnogorac-Jurcevic T
Am J Pathol vol. 180 (4), 1485-1494.  
01-04-2012
Genome Sequencing and Analysis of the Tasmanian Devil and Its Transmissible Cancer
Murchison EP, Schulz-Trieglaff OB, Ning Z, Alexandrov LB, Bauer MJ, Fu B, Hims M, Ding Z et al.
Cell, Elsevier vol. 148 (4), 780-791.  
01-02-2012
Loss of MMP-8 Expression Contributes to Altered Myoepithelial Cell Function in DCIS
Sarper M, Allen M, Decock J, Marshall JF, Edwards DR, Jones JL
 
01-01-2012
Loss of type VII collagen in squamous cell carcinoma increases angiogenesis in vitro and in vivo
Martins V, Caley M, Moore K, Chen M, Marshall J, O'Toole E
 
01-01-2012
MYOEPITHELIAL CONTROL OF THE INFLAMMATORY MICROENVIRONMENT PROMOTES TRANSITION OF DCIS TO INVASIVE DISEASE
Ahmed KO, Allen M, Gomm J, Marshall J, Jones JL
 
01-01-2012
Up-regulation of αvβ6 integrin and fibronectin EDA in myoepithelial cells contribute to the angiogenic switch in pre-invasive breast cancer
Dreger SA, Payne SJ, Dawoud M, Robinson SD, Marshall JF, Hodivala-Dilke KM, Allen MD, Jones JL
 
01-01-2012
Loss of keratinocyte type VII collagen in SCC increases TGF-beta signalling and angiogenesis
Martins V, Caley M, Moore K, Murrell DF, McGrath JA, Chen M, Marshall JF, O'Toole EA
 
01-01-2012
NanoSPECT/CT imaging of pulmonary αvβ6 with [In-111]A20FMDV2 as a surrogate marker for monitoring lung fibrosis
Awais RO, Mather SJ, John AE, Luckett JCA, Habgood A, Jenkins GR, Marshall JF, Perkins AC
 
01-01-2012
NMR relaxation and structural elucidation of peptides in the presence and absence of trifluoroethanol illuminates the critical molecular nature of integrin αvβ6 ligand specificity
Wagstaff JL, Rowe ML, Hsieh S-J, DiCara D, Marshall JF, Williamson RA, Howard MJ
Rsc Advances vol. 2 (29), 11019-11028.  
01-01-2012
TARGETED IN VIVO IMAGING OF THE αVβ6 INTEGRIN IN MICE WITH BLEOMYCIN-INDUCED LUNG FIBROSIS
John AE, Luckett J, Awas R, Habgood A, Ludbrook S, Blanchard A, Perkins A, Jenkins RG et al.
 
01-01-2012

2011

P2-01-05: Integrin avb6 Mediates HER2−Driven Invasion in Breast Cancer.
Moore K, Hart I, Jones L, Marshall J
Cancer Research, American Association For Cancer Research (Aacr) vol. 71 (24_Supplement) 
15-12-2011
Re: Exome Sequencing Identifies Frequent Mutation of the SWI/SNF Complex Gene PBRM1 in Renal Carcinoma
Atala A
Journal of Urology, Wolters Kluwer vol. 186 (3) 
01-09-2011
The role of α9β1 integrin in modulating epithelial cell behaviour
Roy S, Bingle L, Marshall JF, Bass R, Ellis V, Speight PM, Whawell SA
Journal of Oral Pathology and Medicine, Wiley vol. 40 (10), 755-761.  
25-05-2011
Loss of type VII collagen in SCC leads to increased invasion and TGF-beta signalling in vivo
Martins VL, Moore K, Chen M, Marshall J, O'Toole EA
 
11-04-2011
Loss of type VII collagen in squamous cell carcinoma leads to increased invasion and TGF-beta signalling in vivo
Martins V, Moore K, Chen M, Marshall J, O'Toole EA
 
01-04-2011
Psoriasin (S100A7) associates with integrin β6 subunit and is required for αvβ6-dependent carcinoma cell invasion.
Morgan MR, Jazayeri M, Ramsay AG, Thomas GJ, Boulanger MJ, Hart IR, Marshall JF
Oncogene vol. 30 (12), 1422-1435.  
24-03-2011
Stromal features are predictive of disease mortality in oral cancer patients.
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al.
J Pathol vol. 223 (4), 470-481.  
01-03-2011
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.
Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF et al.
J Pathol vol. 223 (3), 366-377.  
01-02-2011
Transwell(®) invasion assays.
Marshall J
Methods Mol Biol vol. 769, 97-110.  
01-01-2011

2010

Stromal features are predictive of disease mortality in oral cancer patients.
Marsh D, Suchak K, Moutasim KA, Vallath S, Hopper C, Jerjes W, Upile T, Kalavrezos N et al.
J Pathol 
25-11-2010
Betel-derived alkaloid up-regulates keratinocyte alphavbeta6 integrin expression and promotes oral submucous fibrosis.
Moutasim KA, Jenei V, Sapienza K, Marsh D, Weinreb PH, Violette SM, Lewis MP, Marshall JF et al.
J Pathol 
27-09-2010
EP4-mediated prostanoid signalling promotes oral cancer progression
Sapienza K, Sale S, Hague A, Hart IR, Marshall JF, Thomas GJ
Bmc Proceedings, Springer Nature vol. 4 (Suppl 2) 
24-09-2010
High-resolution in vivo imaging of breast cancer by targeting the pro-invasive integrin alphavbeta6.
Saha A, Ellison D, Thomas GJ, Vallath S, Mather SJ, Hart IR, Marshall JF
J Pathol vol. 222 (1), 52-63.  
01-09-2010
Alkaloid-dependent upregulation of AlphavBeta6 integrin promotes oral submucous fibrosis
Moutasim KA, Jenei V, Sapienza K, Marsh D, Marshall J, Fortune F, Tilakaratne WM, Hart IR et al.
Oral Dis vol. 16 (6), 528-528.  
01-09-2010
Pancreatic cancer organotypic cultures.
Froeling FEM, Marshall JF, Kocher HM
J Biotechnol vol. 148 (1), 16-23.  
01-07-2010
Inflammation-dependent alpha 5 beta 1 (very late antigen-5) expression on leukocytes reveals a functional role for this integrin in acute peritonitis.
Sampaio ALF, Zahn G, Leoni G, Vossmeyer D, Christner C, Marshall JF, Perretti M
J Leukoc Biol vol. 87 (5), 877-884.  
01-05-2010
Two-dimensional heteronuclear saturation transfer difference NMR reveals detailed integrin alpha v beta 6 protein-peptide interactions
Wagstaff JL, Vallath S, Marshall JF, Williamson RA, Howard MJ
Chem Commun vol. 46 (40), 7533-7535.  
01-01-2010
Dissecting the transcriptional networks underlying breast cancer: NR4A1 reduces the migration of normal and breast cancer cell lines.
Alexopoulou AN, Leao M, Caballero OL, Da Silva L, Reid L, Lakhani SR, Simpson AJ, Marshall JF et al.
Breast Cancer Res vol. 12 (4) 
01-01-2010

2009

Myoepithelial Cells in DCIS Exhibit an Altered Phenotype and Promote Angiogenesis
Payne SJL, Allen M, Dreger S, Marshall J, Hodiavala-Dilke K, Hart I, Jones L
 
15-12-2009
Myoepithelial Cells in DCIS Exhibit an Altered Phenotype and Promote Angiogenesis.
Payne S, Allen M, Dreger S, Marshall J, Hodiavala-Dilke K, Hart I, Jones L
Cancer Research, American Association For Cancer Research (Aacr) vol. 69 (24_Supplement), 2155-2155.  
15-12-2009
DCIS-Associated Myoepithelial Cells Expressing the αvβ6 Integrin Modify Tumour Cell Behaviour: A Predictor of Invasive Progression?
Jones J, Allen M, Thomas G, Dawoud M, Vallath S, Payne S, Edwards D, Pennington C et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 69 (24_Supplement), 4159-4159.  
15-12-2009
Alphav beta3 integrin limits the contribution of neuropilin-1 to vascular endothelial growth factor-induced angiogenesis.
Robinson SD, Reynolds LE, Kostourou V, Reynolds AR, da Silva RG, Tavora B, Baker M, Marshall JF et al.
J Biol Chem vol. 284 (49), 33966-33981.  
04-12-2009
High-throughput in vivo screening of targeted molecular imaging agents
Gagnon MKJ, Hausner SH, Marik J, Abbey CK, Marshall JF, Sutcliffe JL
P Natl Acad Sci Usa vol. 106 (42), 17904-17909.  
20-10-2009
Targeted In vivo Imaging of Integrin alpha(v)beta(6) with an Improved Radiotracer and Its Relevance in a Pancreatic Tumor Model
Hausner SH, Abbey CK, Bold RJ, Gagnon MK, Marik J, Marshall JF, Stanecki CE, Sutcliffe JL
Cancer Res vol. 69 (14), 5843-5850.  
15-07-2009
In vivo retargeting of adenovirus type 5 to alphavbeta6 integrin results in reduced hepatotoxicity and improved tumor uptake following systemic delivery.
Coughlan L, Vallath S, Saha A, Flak M, McNeish IA, Vassaux G, Marshall JF, Hart IR et al.
J Virol vol. 83 (13), 6416-6428.  
01-07-2009
An Ad5 Vector Retargeted to alpha v beta 6 Displays Improved Tumour Transduction Combined with Reduced Liver Uptake Following Systemic Delivery
Coughlan L, Vallath S, Saha A, McNeish IA, Vassaux G, Marshall JF, Hart IR, Thomas GJ
 
01-05-2009
A role for alpha 5 beta 1 integrin in leukocyte accumulation in acute peritonitis
Sampaio ALF, Leoni G, Marshall JF, Perretti M
 
01-04-2009
Evaluation of [Cu-64]Cu-DOTA and [Cu-64]Cu-CB-TE2A Chelates for Targeted Positron Emission Tomography with an alpha(v)beta(6)-Specific Peptide
Hausner SH, Kukis DL, Gagnon MKJ, Stanecki CE, Ferdani R, Marshall JF, Anderson CJ, Sutcliffe JL
Mol Imaging vol. 8 (2), 111-121.  
01-03-2009

2008

Engineering a single-chain Fv antibody to alpha v beta 6 integrin using the specificity-determining loop of a foot-and-mouth disease virus.
Kogelberg H, Tolner B, Thomas GJ, Di Cara D, Minogue S, Ramesh B, Sodha S, Marsh D et al.
J Mol Biol vol. 382 (2), 385-401.  
03-10-2008
Transductional retargeting of adenovirus-5 to alphavbeta6 integrin
Coughlan L, McNeish I, Vassaux G, Marshall J, Hart IR, Thomas G
 
01-10-2008
Existence of multiple isoforms of HS1-associated protein X-1 in murine and human tissues.
Lees DM, Hart IR, Marshall JF
J Mol Biol vol. 379 (4), 645-655.  
13-06-2008
Role of alpha 9 beta 1 integrin in the regulation of epithelial cell behaviour
Roy S, Marshall JF, Speight PM, Whawell SA
 
01-06-2008
alpha v beta 6 integrin promotes the invasion of morphoeic basal cell carcinoma through stromal modulation
Marsh D, Dickinson S, Neill GW, Marshall JF, Hart IR, Thomas GJ
Cancer Res vol. 68 (9), 3295-3303.  
01-05-2008
Foot-and-mouth disease virus forms a highly stable, EDTA-resistant complex with its principal receptor, integrin alphavbeta6: implications for infectiousness.
Dicara D, Burman A, Clark S, Berryman S, Howard MJ, Hart IR, Marshall JF, Jackson T
J Virol vol. 82 (3), 1537-1546.  
01-02-2008
De novo expression of alpha(v)beta(6) integrin by myoepithelial cells in ductal carcinoma in situ may be an important marker of disease progression
Allen M, Mulligan K, Clark S, Hart I, Marshall JF, Jones JL
 
01-01-2008

2007

Expression of alphavbeta6 supersedes Her2 and triple-negative/basal classification of breast cancer and defines novel subgroups with poor survival: implications for breast cancer classification and treatment
Jones JL, Thomas GJ, Duffy SW, Gabe R, Ellis I, Green A, Saha A, Mulligan KT et al.
 
01-12-2007
Molecular profiling of DCIS: identification of distinct subgroups of potential prognostic importance
Clark SE, Marshall JE, Hart IR, Carpenter R, Jones JL
 
01-12-2007
Fibroblast-led collective invasion of carcinoma cells with differing roles for RhoGTPases in leading and following cells.
Gaggioli C, Hooper S, Hidalgo-Carcedo C, Grosse R, Marshall JF, Harrington K, Sahai E
Nat Cell Biol vol. 9 (12), 1392-1400.  
01-12-2007
Integrin trafficking and its role in cancer metastasis.
Ramsay AG, Marshall JF, Hart IR
Cancer Metastasis Rev vol. 26 (3-4), 567-578.  
01-12-2007
CMR 2007: 4.04: Improved molecular imaging probe for in vivo detection of the integrin αvβ6
Hausner SH, Marik J, DiCara D, Abbey CK, Gagnon MKJ, Bold R, Marshall JF, Sutcliffe JL
Contrast Media & Molecular Imaging, Wiley vol. 2 (6), 284-284.  
01-11-2007
Use of a peptide derived from foot-and-mouth disease virus for the Noninvasive Imaging of human cancer: Generation and evaluation of 4-[F-18]fluorobenzoyl A20FMDV2 for in vivo imaging of integrin alpha(v)beta(6) expression with positron emission tomography
Hausner SH, DiCara D, Marik J, Marshall JF, Sutcliffe JL
Cancer Res vol. 67 (16), 7833-7840.  
15-08-2007
HS1-associated protein X-1 regulates carcinoma cell migration and invasion via clathrin-mediated endocytosis of integrin alphavbeta6.
Ramsay AG, Keppler MD, Jazayeri M, Thomas GJ, Parsons M, Violette S, Weinreb P, Hart IR et al.
Cancer Res vol. 67 (11), 5275-5284.  
01-06-2007
Structure-function analysis of Arg-Gly-Asp helix motifs in alpha v beta 6 integrin ligands.
DiCara D, Rapisarda C, Sutcliffe JL, Violette SM, Weinreb PH, Hart IR, Howard MJ, Marshall JF
J Biol Chem vol. 282 (13), 9657-9665.  
30-03-2007

2006

Cyclooxygenase-2 inhibition suppresses alphavbeta6 integrin-dependent oral squamous carcinoma invasion.
Nystrom ML, McCulloch D, Weinreb PH, Violette SM, Speight PM, Marshall JF, Hart IR, Thomas GJ
Cancer Res vol. 66 (22), 10833-10842.  
15-11-2006
Targeting the invasion-association integrin alphavbeta6 as an anti-carcinoma strategy
Hart I, Dicara D, Marshall JF
Ejc Suppl vol. 4 (12), 82-82.  
01-11-2006
Functional analysis of normal and DCIS modified breast myoepithelial cells
Allen M, Mulligan K, Clark S, Hart I, Marshall JF, Jones JL
 
01-01-2006
Alphavbeta6 integrin in wound healing and cancer of the oral cavity.
Thomas GJ, Nyström ML, Marshall JF
J Oral Pathol Med vol. 35 (1), 1-10.  
01-01-2006
S100A7 and the basal phenotype in breast cancer.
Salama I, Mihaimeed F, Marshall J, Jazayeri M, Thomas G, Duffy S, Jones LJ
 
01-01-2006
Tumor cell migration in three dimensions.
Hooper S, Marshall JF, Sahai E
Methods Enzymol vol. 406, 625-643.  
01-01-2006

2005

alpha v beta 6 integrin down-regulates the MMP-13 expression in oral squamous cell carcinoma cells
Ylipalosaari M, Thomas GJ, Nystrom M, Salhimi S, Marshall JF, Huotari V, Tervahartiala T, Sorsa T et al.
Exp Cell Res vol. 309 (2), 273-283.  
01-10-2005
Migration and invasion mechanisms in an in vitro model of squamous cell carcinogenesis
Vyas JJ, Ahmed W, Jayazeri M, Baksh N, Marshall JF, Proby CM, Storey A, O'Toole EA
 
01-04-2005
Mechanisms of migration and invasion of squamous cell carcinoma in an in vitro model of squamous cell carcinogenesis
Vyas J, Ahmed W, Jayazeri M, Marshall JF, Proby CM, Storey A, O'Toole EA
 
01-04-2005
Development of a quantitative method to analyse tumour cell invasion in organotypic culture.
Nyström ML, Thomas GJ, Stone M, Mackenzie IC, Hart IR, Marshall JF
J Pathol vol. 205 (4), 468-475.  
01-03-2005

2004

TNF-alpha regulates epithelial expression of MMP-9 and integrin alphavbeta6 during tumour promotion. A role for TNF-alpha in keratinocyte migration?
Scott KA, Arnott CH, Robinson SC, Moore RJ, Thompson RG, Marshall JF, Balkwill FR
Oncogene vol. 23 (41), 6954-6966.  
09-09-2004
alpha v integrins play an important role in myofibroblast differentiation
Lygoe KA, Norman JT, Marshall JF, Lewis MP
Wound Repair Regen vol. 12 (4), 461-470.  
01-07-2004
A quantitative method for measuring three-dimensional invasion in vitro using organotypic cultures
Nystrom M, Stone M, Thomas GJ, Mackenzie I, Hart IR, Marshall JF
 
01-07-2004
The integrin cytoplasmic-tail motif EKQKVDLSTDC is sufficient to promote tumor cell invasion mediated by matrix metalloproteinase (MMP)-2 or MMP-9.
Morgan MR, Thomas GJ, Russell A, Hart IR, Marshall JF
J Biol Chem vol. 279 (25), 26533-26539.  
18-06-2004
Attenuated type II TGF-B receptor signalling in human malignant oral keratinocytes induces a less differentiated and more aggressive phenotype that is associated with metastatic dissemination
Huntley SP, Davies M, Matthews JB, Thomas G, Marshall J, Robinson CM, Eveson JW, Paterson IC et al.
Int J Cancer vol. 110 (2), 170-176.  
10-06-2004
Modulation of the urokinase-type plasminogen activator receptor by the beta 6 integrin subunit
Dalvi N, Thomas GJ, Marshall JF, Morgan M, Bass R, Ellis V, Speight PM, Whawell SA
Biochem Bioph Res Co vol. 317 (1), 92-99.  
23-04-2004
Reduction of TSG101 protein has a negative impact on tumor cell growth
Zhu G, Gilchrist R, Borley N, Chng HW, Morgan M, Marshall JF, Camplejohn RS, Muir GH et al.
Int J Cancer vol. 109 (4), 541-547.  
20-04-2004
The Integrin Cytoplasmic-tail Motif EKQKVDLSTDC Is Sufficient to Promote Tumor Cell Invasion Mediated by Matrix Metalloproteinase (MMP)-2 or MMP-9*
Morgan MR, Thomas GJ, Russell A, Hart IR, Marshall JF
Journal of Biological Chemistry, Elsevier vol. 279 (25), 26533-26539.  
02-04-2004
Tumour-derived TGF-beta 1 modulates myofibroblast differentiation and promotes HGF/SF-dependent invasion of squamous carcinoma cells
Lewis MP, Lygoe KA, Nystrom ML, Anderson WP, Speight PM, Marshall JF, Thomas GJ
Brit J Cancer vol. 90 (4), 822-832.  
23-02-2004

2003

av beta 6 integrin interaction with the tgf-beta 1 latency-associated peptide (lap).
Thomas GJ, Hart IR, Marshall JF, Speight PM
 
01-12-2003
b6-integrin cytoplasmic tail: novel intracellular target for inhibiting oral scc invasion.
Morgan MR, Thomas GJ, Marshall JF
 
01-12-2003
Restoration of e-cadherin function alters morphology of oral squamous carcinoma cells
Bukhary SM, Assmann V, Marshall JF, Speight PM, Thomas GJ
 
01-12-2003
Desmosomal proteins, including desmoglein 3, serve as novel negative markers for epidermal stem cell-containing population of keratinocytes
Wan H, Stone MG, Simpson C, Reynolds LE, Marshall JF, Hart IR, Hodivala-Dilke KM, Eady RAJ
J Cell Sci vol. 116 (20), 4239-4248.  
15-10-2003
Tumor suppressor p16INK4a determines sensitivity of human cells to transformation by cooperating cellular oncogenes.
Drayton S, Rowe J, Jones R, Vatcheva R, Cuthbert-Heavens D, Marshall J, Fried M, Peters G
Cancer Cell vol. 4 (4), 301-310.  
01-10-2003
Lack of plakophilin 1 increases keratinocyte migration and reduces desmosome stability
South AP, Wan H, Stone MG, Dopping-Hepenstal PJC, Purkis PE, Marshall JF, Leigh IM, Eady RAJ et al.
J Cell Sci vol. 116 (16), 3303-3314.  
15-08-2003
Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer.
Zhu G, Reynolds L, Crnogorac-Jurcevic T, Gillett CE, Dublin EA, Marshall JF, Barnes D, D'Arrigo C et al.
Oncogene vol. 22 (24), 3742-3748.  
12-06-2003
Combination of microdissection and microarray analysis to identify gene expression changes between differentially located tumour cells in breast cancer
Zhu G, Reynolds L, Crnogorac-Jurcevic T, Gillett CE, Dublin EA, Marshall JF, Barnes D, D'Arrigo C et al.
Oncogene, Springer Nature vol. 22 (24), 3742-3748.  
11-06-2003
beta 6-integrin cytoplasmic tail: Novel intracellular target for inhibiting oral SCC invasion.
Morgan MR, Thomas GJ, Marshall JF
J Dent Res vol. 82, B327-B327.  
01-06-2003
An in vitro 3D-Model of Invasive Squamous Cell Carcinoma (SCC) Recapitulates in vivo Pathology
Nystrom M, Thomas G, MacKenzie I, Hart I, Marshall J
Clinical Science, Portland Press vol. 104 (s49), 28p-29p.  
01-04-2003

2002

Differential expression of carcinoembryonic antigen (CEA) splice variants in whole blood of colon cancer patients and healthy volunteers: implication for the detection of circulating colon cancer cells
Hampton R, Walker M, Marshall J, Juhl H
Oncogene vol. 21 (51), 7817-7823.  
07-11-2002
Binding of TGF-beta 1 latency-associated peptide (LAP) to alpha v beta 6 integrin modulates behaviour of squamous carcinoma cells
Thomas GJ, Hart IR, Speight PM, Marshall JF
Brit J Cancer vol. 87 (8), 859-867.  
07-10-2002
The ss 6 integrin subunit C-terminal 11 amino acids are sufficient to promote invasion by squamous cell carcinoma (SCC) cells
Morgan MR, Thomas GJ, Russell A, Speight PM, Hart IR, Marshall JF
Brit J Cancer vol. 86, S120-S120.  
01-06-2002
Rapid solid phase synthesis and biodistribution of F-18-labelled linear peptides
Sutcliffe-Goulden JL, O'Doherty MJ, Marsden PK, Hart IR, Marshall JF, Bansal SS
Eur J Nucl Med Mol I vol. 29 (6), 754-759.  
01-06-2002
Solid phase synthesis of F-18-labelled cyclic peptides.
Sutcliffe-Goulden JL, Marshall JF, O'Doherty MJ, Bansal S
J Nucl Med vol. 43 (5), 365P-365P.  
01-05-2002
First-line oral capecitabine therapy in metastatic colorectal cancer: a favorable safety profile compared with intravenous 5-fluorouracil/leucovorin
Cassidy J, Twelves C, Van Cutsem E, Hoff P, Bajetta E, Boyer M, Bugat R, Burger U et al.
Ann Oncol vol. 13 (4), 566-575.  
01-04-2002

2001

O-029. αvβ6 integrin promotes invasion of squamous carcinoma cells through upregulation of MMP-9
Thomas GJ, Lewis MP, Marshall JF, Speight PM
Oral Oncology vol. 37 (SUPPL. 1) 
01-12-2001
Adenovirus type 5 uptake by lung adenocarcinoma cells in culture correlates with Ad(5) fibre binding is mediated by alpha(v)beta(1) integrin and can be modulated by changes in beta(1) integrin function
Davison E, Kirby I, Whitehouse J, Hart I, Marshall JF, Santis G
J Gene Med vol. 3 (6), 550-559.  
01-11-2001
The terminal 11a.a. cytoplasmic tail of the beta 6 integrin subunit is essential for the promotion of alpha V beta 6-dependent invasion
Morgan MR, Thomas GJ, Speight PM, Hart IR, Marshall JF
Brit J Cancer vol. 85, 22-22.  
01-07-2001
Expression of the alpha v beta 6 integrin promotes migration and invasion in squamous carcinoma cells
Thomas GJ, Lewis MP, Whawell SA, Russell A, Sheppard D, Hart IR, Speight PM, Marshall JF
J Invest Dermatol vol. 117 (1), 67-73.  
01-07-2001
Mechanisms of adhesion-dependence in mouse melanocyte-derived cell lines
Gilchrist R, Stafford H, Duddy PM, Marshall JF, Camplejohn RS, Hart IR
Brit J Cancer vol. 85, 82-82.  
01-07-2001
alpha v beta 6 integrin upregulates matrix metalloproteinase 9 and promotes migration of normal oral keratinocytes
Thomas GJ, Poomsawat S, Lewis MP, Hart IR, Speight PM, Marshall JF
J Invest Dermatol vol. 116 (6), 898-904.  
01-06-2001
alpha V beta 6 integrin promotes invasion of squamous carcinoma cells through up-regulation of matrix metalloproteinase-9
Thomas GJ, Lewis MP, Hart IR, Marshall JF, Speight PM
Int J Cancer vol. 92 (5), 641-650.  
01-06-2001
alpha v beta 6-dependent upregulation of MMP-9 promotes keratinocyte migration.
Thomas GJ, Poomsawat S, Lewis MP, Marshall JF, Speight PM
J Dent Res vol. 80 (4), 1155-1155.  
01-04-2001
beta(3)A-integrin downregulates the urokinase-type plasminogen activator receptor (u-PAR) through a PEA3/ets transcriptional silencing element in the u-PAR promoter
Hapke S, Gawaz M, Dehne K, Kohler J, Marshall JF, Graeff H, Schmitt M, Reuning U et al.
Mol Cell Biol vol. 21 (6), 2118-2132.  
01-03-2001
The Protrusive Phase and Full Development of Integrin-Dependent Adhesions in Colon Epithelial Cells Require FAK- and ERKMediated Actin Spike Formation: Deregulation in Cancer Cells
Brunton VG, Fincham VJ, McLean GW, Winder SJ, Paraskeva C, Marshall JF, Frame MC
Neoplasia, Elsevier vol. 3 (3), 215-226.  
01-01-2001

2000

The Integrins α3β1 and α6β1 Physically and Functionally Associate with CD36 in Human Melanoma Cells REQUIREMENT FOR THE EXTRACELLULAR DOMAIN OF CD36*
Thorne RF, Marshall JF, Shafren DR, Gibson PG, Hart IR, Burns GF
Journal of Biological Chemistry, Elsevier vol. 275 (45), 35264-35275.  
01-11-2000
Photo-Induced Inactivation of Protein Kinase Cα by Dequalinium Inhibits Motility of Murine Melanoma Cells
Sullivan RM, Stone M, Marshall JF, Uberall F, Rotenberg SA
Molecular Pharmacology, Elsevier vol. 58 (4), 729-737.  
01-10-2000
Functional interaction between E-cadherin and alphav-containing integrins in carcinoma cells
Schlippe MV, Marshall JF, Perry P, Stone M, Zhu AJ, Hart IR
Journal of Cell Science, The Company of Biologists vol. 113 (3), 425-437.  
01-02-2000
In vivo therapy of malignant melanoma by means of antagonists of αv integrins
Mitjans F, Meyer T, Fittschen C, Goodman S, Jonczyk A, Marshall JF, Reyes G, Piulats J
International Journal of Cancer, Wiley vol. 87 (5), 716-723.  
01-01-2000

1999

The intracellular hyaluronan receptor RHAMM/IHABP interacts with microtubules and actin filaments
Assmann V, Jenkinson D, Marshall JF, Hart IR
Journal of Cell Science, The Company of Biologists vol. 112 (22), 3943-3954.  
15-11-1999
Chemokines induce the cellular migration of MCF-7 human breast carcinoma cells: Subpopulations of tumour cells display positive and negative chemotaxis and differential in vivo growth potentials
Prest SJ, Rees RC, Murdoch C, Marshall JF, Cooper PA, Bibby M, Li G, Ali SA
Clinical & Experimental Metastasis, Springer Nature vol. 17 (5), 389-396.  
01-07-1999
The Role of Adhesion in Metastasis: Potential Mechanisms and Modulation of Integrin Activity
Marshall JF, Hart IR
Advances in Molecular and Cell Biology, Elsevier vol. 28, 345-365.  
01-01-1999

1998

Fibronectin is chemotactic for CT 26 colon carcinoma cells: sub-lines selected for increased chemotaxis to fibronectin display decreased tumorigenicity and lung colonization
Geng L, Ali SA, Marshall JF, Mackay CL, Hart IR, Delcommence M, Streuli CH, Rees RC
Clinical & Experimental Metastasis, Springer Nature vol. 16 (8), 683-691.  
01-11-1998
The human hyaluronan receptor RHAMM is expressed as an intracellular protein in breast cancer cells
Assmann V, Marshall JF, Fieber C, Hofmann M, Hart IR
Journal of Cell Science, The Company of Biologists vol. 111 (12), 1685-1694.  
15-06-1998
Hypoxia facilitates tumour cell detachment by reducing expression of surface adhesion molecules and adhesion to extracellular matrices without loss of cell viability
Hasan N, Adams G, Joiner M, Marshall J, Hart I
British Journal of Cancer, Springer Nature vol. 77 (11), 1799-1805.  
01-06-1998
Comparative analysis of integrins in vitro and in vivo in uveal and cutaneous melanomas
Marshall J, Rutherford D, Happerfield L, Hanby A, McCartney A, Newton-Bishop J, Hart I
British Journal of Cancer, Springer Nature vol. 77 (4), 522-529.  
01-02-1998
Expression of αv integrins and vitronectin receptor identity in breast cancer cells
Meyer T, Marshall J, Hart I
British Journal of Cancer, Springer Nature vol. 77 (4), 530-536.  
01-02-1998

1997

Modulation of human stromelysin 3 promoter activity and gene expression by human breast cancer cells
Ahmad A, Marshall JF, Basset P, Anglard P, Hart IR
International Journal of Cancer, Wiley vol. 73 (2), 290-296.  
09-10-1997
Activation status and function of the VLA‐4 (α4β1) integrin expressed on human melanoma cell lines
Saini A, Seller Z, Davies D, Marshall JF, Hart IR
International Journal of Cancer, Wiley vol. 73 (2), 264-270.  
09-10-1997
Integrin alpha5beta1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16
Davison E, Diaz RM, Hart IR, Santis G, Marshall JF
Journal of Virology, American Society For Microbiology vol. 71 (8), 6204-6207.  
01-08-1997
Generation of an anti‐tumour immune response in a non‐immunogenic tumour: HSVtk killing in vivo stimulates a mononuclear cell infiltrate and a Th1‐like profile of intratumoural cytokine expression
Vile RG, Castleden S, Marshall J, Camplejohn R, Upton C, Chong H
International Journal of Cancer, Wiley vol. 71 (2), 267-274.  
10-04-1997

1996

Identification by differential display of annexin-VI, a gene differentially expressed during melanoma progression.
Francia G, Mitchell SD, Moss SE, Hanby AM, Marshall JF, Hart IR
Cancer Research vol. 56 (17), 3855-3858.  
01-09-1996
The role of αv-integrins in tumour progression and metastasis
Marshall JF, Hart IR
Seminars in Cancer Biology, Elsevier vol. 7 (3), 129-138.  
01-06-1996

1995

αvβ1 is a receptor for vitronectin and fibrinogen, and acts with α5β1 to mediate spreading on fibronectin
Marshall JF, Rutherford DC, McCartney ACE, Mitjans F, Goodman SL, Hart IR
Journal of Cell Science, The Company of Biologists vol. 108 (3), 1227-1238.  
01-03-1995

1992

Cell and tissue responses of a murine tumour to phthalocyanine-mediated photodynamic therapy
van Bruggen N, Chan W-S, Syha J, Marshall JF, Proctor E, Williams SR, Gadian DG, Hart IR
European Journal of Cancer, Elsevier vol. 28 (1), 42-46.  
01-01-1992

1991

Integrin expression in human melanoma cell lines: Heterogeneity of vitronectin receptor composition and function
Marshall JF, Nesbitt SA, Helfrich MH, Horton MA, Polakova K, Hart IR
International Journal of Cancer, Wiley vol. 49 (6), 924-931.  
01-12-1991
Influence of tumor-derived interleukin 1 on melanoma-endothelial cell interactions in vitro.
Burrows FJ, Haskard DO, Hart IR, Marshall JF, Selkirk S, Poole S, Thorpe PE
Cancer Research vol. 51 (18), 4768-4775.  
15-09-1991
Cell adhesion receptor expression during melanoma progression and metastasis
Hart IR, Birch M, Marshall JF
Cancer and Metastasis Reviews, Springer Nature vol. 10 (2), 115-128.  
01-06-1991

1990

Effect of sulfonation on the cell and tissue distribution of the photosensitizer aluminum phthalocyanine.
Chan WS, Marshall JF, Svensen R, Bedwell J, Hart IR
Cancer Research vol. 50 (15), 4533-4538.  
01-08-1990

1989

EFFECT OF PHOTODYNAMIC THERAPY ON ANTITUMOR IMMUNE DEFENSES: COMPARISON OF THE PHOTOSENSITIZERS HEMATOPORPHYRIN DERIVATIVE AND CHLORO‐ALUMINUM SULFONATED PHTHALOCYANINE
MARSHALL JF, CHAN W, HART IR
Photochemistry and Photobiology, Wiley vol. 49 (5), 627-632.  
01-05-1989
Effect of tumour location on selective uptake and retention of phthalocyanines
Chan W-S, Marshall JF, Hart IR
Cancer Letters, Elsevier vol. 44 (1), 73-77.  
01-01-1989

1988

Tissue uptake, distribution, and potency of the photoactivatable dye chloroaluminum sulfonated phthalocyanine in mice bearing transplantable tumors.
Chan WS, Marshall JF, Lam GY, Hart IR
Cancer Research vol. 48 (11), 3040-3044.  
01-06-1988

1987

PHOTODYNAMIC THERAPY OF A MURINE TUMOR FOLLOWING SENSITISATION WITH CHLORO ALUMINUM SULFONATED PHTHALOCYANINE
Chan W, Marshall JF, Hart IR
Photochemistry and Photobiology, Wiley vol. 46 (5), 867-871.  
01-11-1987
PHOTOSENSITISING ACTIVITY OF PHTHALOCYANINE DYES SCREENED AGAINST TISSUE CULTURE CELLS
Chan W, Marshall JF, Svensen R, Phillips D, Hart IR
Photochemistry and Photobiology, Wiley vol. 45 (6), 757-761.  
01-05-1987

1985

Changes in surface structure and concanavalin A-binding capacity of urothelium in the mouse bladder after whole-body neutron irradiation.
Hodges GM, Carr KE, Hume SP, Marigold JC, Southgate J, Marshall JF
Scanning Microscopy (Pt 4), 1603-1614.  
01-01-1985

Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer
Laforêts F, Kotantaki P, Elorbany S, Hartlebury J, Joy JD, Malacrida B, Bryan-Ravenscroft RC, Berlato C et al.
In Biorxiv 
Pancreatic cancer metastasis is regulated by an eleven amino-acid sequence
Fuertes G, Di Biagio D, Sontakke RP, Maniati E, Jenkins B, Thomas GJ, Marshall JF
In Biorxiv 
Ephrin inhibition disrupts stromal-cancer crosstalk and reduces metastasis in pancreatic cancer
Bolton CL, O’Sullivan R, Fuertes-Marin G, Sprouse F, Wang H, Menezes S, Tan AC, Simoncelli S et al.
In Biorxiv 
Integrin αVβ6-EGFR crosstalk regulates bidirectional force transmission and controls breast cancer invasion
Thomas JR, Moore KM, Sproat C, Maldonado-Lorca HJ, Mo S, Haider S, Hammond D, Thomas GJ et al.
In Biorxiv 
A trafficking regulatory subnetwork governs αVβ6 Integrin-HER2 crosstalk to control breast cancer invasion and drug resistance
Maldonado H, Dreger M, Wolanska K, Kyriakou T, Marotta V, Webster J, Wang J, Rusilowicz-Jones E et al.
In Research Square