Dr Joash Joy
Post Doctoral Research Fellow
Barts Cancer Institute
Research
Organ-on-a-chip, CAR-T cells, Ovarian Cancer, 3D in vitro models
Interests
Developing and testing 3D in vitro multicellular models of ovarian cancer, including ovarian cancer-on-a-chip.Publications
Publications of specific relevance to Predictive in vitro Models2023
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J and Balkwill F (2023). Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer. American Association For Cancer Research (Aacr) Cancer Research vol. 83, (7_Supplement) 4576-4576. 10.1158/1538-7445.am2023-45762022
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S, Athanasopoulos T, Ali S, Emery-Billcliff P, Ricciardelli I, Kay C, Colebrook J, Ali M, Strong K and Balkwill F (2022). Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer. American Association For Cancer Research (Aacr) Cancer Research vol. 82, (12_Supplement) 693-693. 10.1158/1538-7445.am2022-6932020
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OMT, Hirani P, Joy JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P and Balkwill FR (2020). Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Elsevier Cell Reports vol. 30, (2) 525-540.e7. 10.1016/j.celrep.2019.12.034Grants
Advanced solid tissue models of T-cell migration and activityJoy JD
Biotechnology and Biological Sciences Research Council (25-09-2017 - 30-03-2022)