Dr Joash Joy

Joash Joy

Post Doctoral Research Fellow

Barts Cancer Institute
Queen Mary University of London

Research

Organ-on-a-chip, CAR-T cells, Ovarian Cancer, 3D in vitro models

Interests

Developing and testing 3D in vitro multicellular models of ovarian cancer, including ovarian cancer-on-a-chip.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2024

Human 3D ovarian cancer models reveal 1 malignant cell intrinsic and extrinsic factors that 2 influence CAR T cell activity
Joy J, Manchanda R, Balkwill F
Cancer Research 
31-05-2024
Abstract B079: Human 3D ovarian cancer models reveal malignant cell intrinsic and extrinsic factors that influence CAR-T cell activity
Joy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Manchanda R, Hopkins S, Garrobo-Calleja I et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 84 (5_Supplement_2), b079-b079.  
04-03-2024

2023

Abstract 4576: 3D in vitro models uncover malignant cell intrinsic and extrinsic mechanisms of CAR-T cell resistance in high grade serous ovarian cancer
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Garrobo-Calleja I, Gautrot J et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 83 (7_Supplement), 4576-4576.  
04-04-2023

2022

Abstract 693: TGFβ-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer
Joy JD, Malacrida B, Laforêts F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 82 (12_Supplement), 693-693.  
15-06-2022
TGFß-mediated targeting of the extracellular matrix enhances the migration and cytotoxicity of CAR-T cells in 3D models of ovarian cancer
Joy JD, Malacrida B, Laforets F, Kotantaki P, Maniati E, Hopkins S, Calleja I, Brett S et al.
 
01-01-2022

2020

Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment
Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C et al.
Cell Reports, Elsevier vol. 30 (2), 525-540.e7.  
01-01-2020

Matrix structure and microenvironment dynamics correlate with chemotherapy response in ovarian cancer
Laforêts F, Kotantaki P, Elorbany S, Hartlebury J, Joy JD, Malacrida B, Bryan-Ravenscroft RC, Berlato C et al.
In Biorxiv