Research

tissue architecture, cytoskeletons, human stem cells, drosophila, organoids, cerebral organoids, healthy and diseased, neurodegeneration

Neuronal Models

Interests

Techniques: Drosophila, 2D and 3D cell culture models and human organoids.
Reserach:
1. Tissue Biomechanics in the Whole Organism. Our research group focuses on understanding the genetic and cell biophysics of cell and tissue organisation in a multicellular organism, using Drosophila melanogaster as a model system. These are basic cellular processes that are conserved in the development of all organisms, and that contribute to diseases when mis-regulated.
2. Tissue biomechanics in 3D Human Cerebral Organoids. Limited knowledge exists regarding how morphogenesis and tissue architecture may contribute to the development of our brain. Combining bioengineering, cell biophysics and functional genetics we are studying the biophysical principles governing neuro-epithelia formation, the early brain development stage.
Experimental biophysicists and biologists are welcome to join us. https://palacioslabqmul.squarespace.com/research

Isa is also a co-founder of the DrosAfrica charity (https://drosafrica.org), building a connected African biomedical research community using Drosophila as a model system.

Grants