Dr Isabel M Palacios
Lecturer
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
tissue architecture, cytoskeletons, human stem cells, drosophila, organoids, cerebral organoids, healthy and diseased, neurodegeneration
Interests
Techniques: Drosophila, 2D and 3D cell culture models and human organoids.Reserach:
1. Tissue Biomechanics in the Whole Organism. Our research group focuses on understanding the genetic and cell biophysics of cell and tissue organisation in a multicellular organism, using Drosophila melanogaster as a model system. These are basic cellular processes that are conserved in the development of all organisms, and that contribute to diseases when mis-regulated.
2. Tissue biomechanics in 3D Human Cerebral Organoids. Limited knowledge exists regarding how morphogenesis and tissue architecture may contribute to the development of our brain. Combining bioengineering, cell biophysics and functional genetics we are studying the biophysical principles governing neuro-epithelia formation, the early brain development stage.
Experimental biophysicists and biologists are welcome to join us. https://palacioslabqmul.squarespace.com/research
Isa is also a co-founder of the DrosAfrica charity (https://drosafrica.org), building a connected African biomedical research community using Drosophila as a model system.
Publications
2024
Essential conserved neuronal motors kinesin-1 and kinesin-3 regulate Aβ42 toxicity in vivoPalacios IM, Palacios De Castro MI
Biorxiv Journal
24-04-2024
2023
Constriction imposed by basement membrane regulates developmental cell migrationLópez EM, Kabanova A, Winkel A, Franze K, Palacios IM, Martín-Bermudo MD
Plos Biology, Public Library of Science vol. 21 (6)
28-06-2023
2020
The humble fruit fly is helping the African science community to thrivePalacios I, Vicente-Crespo M, Martín-Bermudo MD
Nature Reviews Molecular Cell Biology, Springer Nature vol. 21 (10), 558-559.
17-08-2020
Integrins regulate epithelial cell shape by controlling the architecture and mechanical properties of basal actomyosin networksSanta-Cruz Mateos C, Valencia-Expósito A, Palacios IM, Martín-Bermudo MD
Plos Genetics, Public Library of Science (Plos) vol. 16 (6), e1008717-e1008717.
01-06-2020
Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules in the Drosophila oocyte.Drechsler M, Lang LF, Al-Khatib L, Dirks H, Burger M, Schönlieb C-B, Palacios IM
Molecular Biology of The Cell, American Society For Cell Biology, mbcE1908044-mbcE1908044.
08-04-2020
2019
YAP/Yorkie in the germline modulates the age-related decline of germline stem cells and niche cellsFrancis D, Chanana B, Fernandez B, Gordon B, Mak T, Palacios IM
Plos One, Public Library of Science (Plos) vol. 14 (4)
03-04-2019
2017
Active diffusion and advection in Drosophila oocytes result from the interplay of actin and microtubulesPALACIOS IM
Nature Communications, Nature Publishing Group vol. 8
15-11-2017
DrosAfrica: Building an African biomedical research community using DrosophilaMartín-Bermudo MD, Gebel L, Palacios IM
Seminars in Cell & Developmental Biology, Elsevier Bv vol. 70, 58-64.
30-08-2017
2016
α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epitheliumNg BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD, Palacios IM
Journal of Cell Science, The Company of Biologists vol. 129 (9), e1.2-e1.2.
01-05-2016
Workshop‐Based Training for Capacity Building: Using Drosophila to Bring Research Skills to AfricaVicente‐Crespo M, Muñoz‐Descalzo S, Martín‐Bermudo MD
01-04-2016
α-Spectrin and integrins act together to regulate actomyosin and columnarization, and to maintain a monolayered follicular epitheliumNg BF, Selvaraj GK, Santa-Cruz Mateos C, Grosheva I, Alvarez-Garcia I, Martín-Bermudo MD, Palacios IM
Development, The Company of Biologists vol. 143 (8), 1388-1399.
07-03-2016
Planar cell polarity: the Dachsous/Fat system contributes differently to the embryonic and larval stages of DrosophilaSaavedra P, Brittle A, Palacios IM, Strutt D, Casal J, Lawrence PA
Biology Open, The Company of Biologists vol. 5 (4), 397-408.
02-03-2016
2015
A complex relationship between motor activity, cytoplasmic flows and the organisation of the actin and microtubule cytoskeletonsPalacios IM, Drechsler M, Ganguly S
01-01-2015
Alpha-spectrin is essential for septate junction formation and columnarization, but not for proliferation control, in the follicular epitheliumPalacios IM, Martin-Bermudo M
01-01-2015
A complex relationship between motor activity, cytoplasmic flows and the organisation of the actin and microtubule cytoskeletons.Palacios IM, Drechsler M
01-01-2015
2014
Hop-on hop-off: Polysomes take a tour of the cell on endosomesPalacios IM
Journal of Cell Biology, Rockefeller University Press vol. 204 (3), 287-289.
03-02-2014
Plasticity of both planar cell polarity and cell identity during the development of DrosophilaSaavedra P, Vincent J-P, Palacios IM, Lawrence PA, Casal J
Elife, Elife vol. 3
01-01-2014
Integrins regulate epithelial cell differentiation by modulating Notch activityGómez-Lamarca MJ, Cobreros-Reguera L, Ibáñez-Jiménez B, Palacios IM, Martín-Bermudo MD
Journal of Cell Science, The Company of Biologists vol. 127 (21), 4667-4678.
01-01-2014
Epithelia patterning and body plan mapping in the Drosophila egg chamber: cell fate specific screenBraun AL, Chanana B
01-01-2014
A combined cell biological and biophysical strategy to analyze actin/microtubule crosstalk and its relation to cytoplasmic streaming.Drechsler M, Goldstein R
01-01-2014
The auto-inhibitory domain and ATP-independent microtubulebinding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germlineWilliams LS, Ganguly S, Loiseau P, Ng BF
Journal of Cell Science, The Company of Biologists vol. 127 (1), e1-e1.
01-01-2014
2013
How are spoken skills assessed in proficiency tests of general English as a Foreign Language? A preliminary surveyRoca-Varela ML, Palacios IM
International Journal of English Studies, Servicio De Publicaciones De La Universidad De Murcia vol. 13 (2), 53-68.
01-12-2013
The auto-inhibitory domain and ATP-independent microtubule-binding region of Kinesin heavy chain are major functional domains for transport in the Drosophila germlineWilliams LS, Ganguly S, Loiseau P, Ng BF, Palacios IM
Development, The Company of Biologists vol. 141 (1), 176-186.
20-11-2013
2012
Nonsense-mediated mRNA decay: from mechanistic insights to impacts on human healthPalacios IM
Briefings in Functional Genomics, Oxford University Press (Oup) vol. 12 (1), 25-36.
11-11-2012
Cytoplasmic streaming in Drosophila oocytes varies with kinesin activity and correlates with the microtubule cytoskeleton architectureGanguly S, Williams LS, Palacios IM, Goldstein RE
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 109 (38), 15109-15114.
04-09-2012
HIGHER EDUCATION IN THE DEVELOPING WORLD: DROSOPHILA NEUROGENETICS, UGANDABaden T, Palacios I, Vicente M, Godino LP
01-01-2012
2011
Drosophila Upf1 and Upf2 loss of function inhibits cell growth and causes animal death in a Upf3-independent mannerAvery P, Vicente-Crespo M, Francis D, Nashchekina O, Alonso CR, Palacios IM
Rna, Cold Spring Harbor Laboratory vol. 17 (4), 624-638.
11-02-2011
Nonsense-mediated mRNA decay and development: shoot the messenger to survive?Vicente-Crespo M, Palacios IM
Biochemical Society Transactions, Portland Press vol. 39 (1), 411-411.
19-01-2011
2010
Nonsense-mediated mRNA decay and development: shoot the messenger to survive?Vicente-Crespo M, Palacios IM
Biochemical Society Transactions, Portland Press vol. 38 (6), 1500-1505.
24-11-2010
Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motilityLoiseau P, Davies T, Williams LS
Journal of Cell Science, The Company of Biologists vol. 123 (16), e1-e1.
15-08-2010
Drosophila PAT1 is required for Kinesin-1 to transport cargo and to maximize its motilityLoiseau P, Davies T, Williams LS
Development, The Company of Biologists vol. 137 (16), 2763-2772.
14-07-2010
2007
The Salvador-Warts-Hippo Pathway Is Required for Epithelial Proliferation and Axis Specification in DrosophilaMeignin C, Alvarez-Garcia I, Davis I, Palacios IM
Current Biology, Elsevier vol. 17 (21), 1871-1878.
25-10-2007
How does an mRNA find its way? Intracellular localisation of transcriptsPalacios IM
Seminars in Cell and Developmental Biology, Elsevier vol. 18 (2), 163-170.
26-01-2007
2004
An eIF4AIII-containing complex required for mRNA localization and nonsense-mediated mRNA decayPalacios IM, Gatfield D, St Johnston D, Izaurralde E
Nature, Springer Nature vol. 427 (6976), 753-757.
01-02-2004
2003
Barentsz, a New Component of the Staufen-Containing Ribonucleoprotein Particles in Mammalian Cells, Interacts with Staufen in an RNA-Dependent MannerMacchi P, Kroening S, Palacios IM, Baldassa S, Grunewald B, Ambrosino C, Goetze B, Lupas A et al.
Journal of Neuroscience, Society For Neuroscience vol. 23 (13), 5778-5788.
02-07-2003
2002
Kinesin light chain-independent function of the Kinesin heavy chain in cytoplasmic streaming and posterior localisation in theDrosophila oocytePalacios IM, St Johnston D
Development, The Company of Biologists vol. 129 (23), 5473-5485.
01-12-2002
Drosophila 14-3-3/PAR-5 Is an Essential Mediator of PAR-1 Function in Axis FormationBenton R, Palacios IM, St Johnston D
Developmental Cell, Elsevier vol. 3 (5), 659-671.
01-11-2002
RNA Processing: Splicing and the Cytoplasmic Localisation of mRNAPalacios IM
Current Biology, Elsevier vol. 12 (2), r50-r52.
01-01-2002
2001
GETTING THE MESSAGE ACROSS: The Intracellular Localization of mRNAs in Higher EukaryotesPalacios IM, Johnston DS
Annual Review of Cell and Developmental Biology, Annual Reviews vol. 17 (1), 569-614.
01-11-2001
Dimerization of the 3′UTR of bicoid mRNA involves a two-step mechanism11Edited by J. DoudnaWagner C, Palacios I, Jaeger L, St Johnston D, Ehresmann B, Ehresmann C, Brunel C
Journal of Molecular Biology, Elsevier vol. 313 (3), 511-524.
01-10-2001
Barentsz is essential for the posterior localization of oskar mRNA and colocalizes with it to the posterior polevan Eeden FJM, Palacios IM, Petronczki M, Weston MJD, St Johnston D
Journal of Cell Biology, Rockefeller University Press vol. 154 (3), 511-524.
30-07-2001
RNA Intracellular TransportPalacios I
In Encyclopedia of Life Sciences, Wiley
19-04-2001
1997
Nuclear import of U snRNPs requires importin βPalacios I, Hetzer M, Adam SA
The Embo Journal, Springer Nature vol. 16 (22), 6783-6792.
15-11-1997
An immersion in nucleocytoplasmic transport at the Garda lakePalacios I
01-02-1997
Chapter 23 In Vitro Systems for the Reconstitution of snRNP and Protein Nuclear ImportDingwall C
Methods in Cell Biology, Elsevier vol. 53, 517-543.
01-01-1997
1996
RAN/TC4 mutants identify a common requirement for snRNP and protein import into the nucleus.Palacios I, Weis K, Klebe C
Journal of Cell Biology, Rockefeller University Press vol. 133 (3), 485-494.
01-05-1996
Mutational analysis identifies functional domains in the influenza A virus PB2 polymerase subunitPerales B, de la Luna S, Palacios I, Ortín J
Journal of Virology, American Society For Microbiology vol. 70 (3), 1678-1686.
01-03-1996
1995
Nuclear retention of RNA as a mechanism for localization.Boelens WC, Palacios I
Rna vol. 1 (3), 273-283.
01-05-1995
Artificial Cells Evidence Apical Compressive Forces Building up During Neuroepithelial Organoid Early DevelopmentIn Biorxiv
Mechanical context defines integrin requirement for maintaining epithelia architectureRincón-Ortega L, Fernández-Espartero CH, Palacios IM, González-Reyes A, Martín-Bermudo MD
In Biorxiv
Optical flow analysis reveals that Kinesin-mediated advection impacts on the orientation of microtubules in the Drosophila oocyteIn Biorxiv
Integrins control tissue morphogenesis and homeostasis by sustaining the different types of intracellular actin networksIn Biorxiv
Active diffusion and advection in the Drosophila ooplasm result from the interplay of the actin and microtubule cytoskeletonsIn Biorxiv
Grants
Grants of specific relevance to Predictive in vitro ModelsHighthroughput Light Sheet Microscopy: Imaging Across ScalesViji Draviam Sastry, Caroline Brennan, Vidya Darbari, Jose Martin Duran, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023
A confocal microscope for multidisciplinary dynamic studies of complex biological systemsConrad Mullineaux, Caroline Brennan, Alexandre De Mendoza Soler, Viji Draviam Sastry, Maurice Elphick, Christoph Engl, Isabel M Palacios, Matteo Palma, Marina Resmini, Alexander Ruban, Peter Thorpe, Angelika Stollewerk, Jose Martin Duran, Paulo Baptista Ribeiro, Susana Godinho, Richard Grose, Stephanie Kermorgant, Peter McCormick and Tyson Sharp
£390,834 BBSRC Biotechnology and Biological Sciences Research Council
01-08-2022 - 31-07-2023