Dr GIANMICHELE MASSIMO
Queen Mary University of Londong.email@example.com
InterestsMy research activity aims to understand how genetic mutations of the xanthine oxidase enzyme affect its activity. To do that, I developed a stable cell line of hXDH-HEK-293. Since my first steps in science, I have been using primary and secondary cell lines for my research activity. Now I am more in than phase where I want to learn how to develop a 3-D cell model and understand what sort of advantages I could get from this approach for my current and future project.
Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP, Filomena F, Nuredini G, Ibrahim AS, Khambata RS, Gupta AK, Moon JC, Kapil V and Ahluwalia A (2021). Inorganic nitrate attenuates cardiac dysfunction: role for xanthine oxidoreductase and nitric oxide. Br J Pharmacol 10.1111/bph.15636
Kapil V, Khambata RS, Jones DA, Rathod K, Primus C, Massimo G, Fukuto JM and Ahluwalia A (2020). The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway. Pharmacological Reviews vol. 72, (3) 692-766. 10.1124/pr.120.019240