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Dr GIANMICHELE MASSIMO

GIANMICHELE MASSIMO
Queen Mary University of London

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Research

Interests

My research activity aims to understand how genetic mutations of the xanthine oxidase enzyme affect its activity. To do that, I developed a stable cell line of hXDH-HEK-293. Since my first steps in science, I have been using primary and secondary cell lines for my research activity. Now I am more in than phase where I want to learn how to develop a 3-D cell model and understand what sort of advantages I could get from this approach for my current and future project.

Publications

Publications of specific relevance to Predictive in vitro Models

2021

Gee LC, Massimo G, Lau C, Primus C, Fernandes D, Chen J, Rathod KS, Hamers AJP, Filomena F, Nuredini G, Ibrahim AS, Khambata RS, Gupta AK, Moon JC, Kapil V and Ahluwalia A (2021). Inorganic nitrate attenuates cardiac dysfunction: role for xanthine oxidoreductase and nitric oxide. Br J Pharmacol  10.1111/bph.15636

2020

Kapil V, Khambata RS, Jones DA, Rathod K, Primus C, Massimo G, Fukuto JM and Ahluwalia A (2020). The Noncanonical Pathway for In Vivo Nitric Oxide Generation: The Nitrate-Nitrite-Nitric Oxide Pathway. Pharmacological Reviews  vol. 72, (3) 692-766. 10.1124/pr.120.019240

2018

Chen J, Hamers AJP, Finsterbusch M, Massimo G, Zafar M, Corder R, Colas RA, Dalli J, Thiemermann C and Ahluwalia A (2018). Endogenously generated arachidonate-derived ligands for TRPV1 induce cardiac protection in sepsis. Faseb J  fj201701303-fj201701303. 10.1096/fj.201701303R