Dr Gunnel Halldén
Academic
Research
oncolytic virus, prostate cancer, pancreatic cancer
Interests
virology, adenovirus, cell killing modes, novel therapeuticsPublications
2021
Gonzalez-Pastor R, Hernandez Y, Gimeno M, de Martino A, Man YKS, Hallden G, Quintanilla M, de la Fuente JM and Martin-Duque P (2021). Coating an adenovirus with functionalized gold nanoparticles favors uptake, intracellular trafficking and anti-cancer therapeutic efficacy. Acta Biomaterialia vol. 134, 593-604. 10.1016/j.actbio.2021.07.047
2019
Stella Man YK, Foster J, Carapuça E, Davies JA, Parker AL, Sosabowski J and Halldén G (2019). Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer. Scientific Reports vol. 9, (1) 10.1038/s41598-019-49150-9
Hallden G, Wang Y, Wong H-H and Lemoine NR (2019). ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY. Advanced Textbook On Gene Transfer, Gene Therapy and Genetic Pharmacology 10.1142/9781786346889_0019
2018
Nattress CB and Halldén G (2018). Advances in oncolytic adenovirus therapy for pancreatic cancer. Cancer Letters vol. 434, 56-69. 10.1016/j.canlet.2018.07.006
Baker AT, Aguirre-Hernández C, Halldén G and Parker AL (2018). Designer oncolytic adenovirus: Coming of age. Cancers vol. 10, (6) 10.3390/cancers10060201
Man YKS, Davies JA, Coughlan L, Pantelidou C, Blázquez-Moreno A, Marshall JF, Parker AL and Halldén G (2018). The novel oncolytic adenoviral mutant Ad5-3Δ-A20T retargeted to αvβ6 integrins efficiently eliminates pancreatic cancer cells. Molecular Cancer Therapeutics vol. 17, (2) 575-587. 10.1158/1535-7163.MCT-17-0671
Aguirre-Hernández C, Maya-Pineda H, Millán JS, Man YKS, Lu YJ and Halldén G (2018). Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus AdΔΔ through Bcl-2-dependent attenuation of autophagy. Oncogenesis vol. 7, (1) 10.1038/s41389-017-0020-8
2017
Hallden G (2017). Targeting pancreatic and prostate cancer with E1B19K-deleted oncolytic adenoviruses. Human Gene Therapy vol. 28, (8) A6-A6.
2016
Aguirre-Hernandez C, Millan JS and Hallden G (2016). The adenoviral Ad Delta Delta mutant enhances mitoxantrone-induced apoptosis and attenuates drug-induced autophagy in prostate cancer cells.
Pantelidou C, Cherubini G, Lemoine NR and Halldén G (2016). The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11. Oncotarget vol. 7, (13) 15703-15724. 10.18632/oncotarget.7310
Sweeney K and Halldén G (2016). Oncolytic adenovirus-mediated therapy for prostate cancer. Oncolytic Virother vol. 5, 45-57. 10.2147/OV.S63047
Pantelidou C, Man YKS, Coughlan L, Marshall J, Kocher H and Hallden G (2016). Oncolytic adenoviral mutants deleted in the anti-apoptotic E1B19K gene sensitize pancreatic cancer cells to drug-induced DNA damage. International Journal of Molecular Medicine vol. 38, S58-S58.
2014
Hallden G, Wang Y, Wong H-H and Lemoine NR (2014). 18: ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY. Advanced Textbook On Gene Transfer, Gene Therapy and Genetic Pharmacology 10.1142/9781848168305_0018
2013
Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D and Portella G (2013). Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells. Endocr Relat Cancer vol. 20, (5) 633-647. 10.1530/ERC-13-0001
2012
Halldén G and Portella G (2012). Oncolytic virotherapy with modified adenoviruses and novel therapeutic targets. Expert Opin Ther Targets vol. 16, (10) 945-958. 10.1517/14728222.2012.712962
Adam V, Ekblad M, Sweeney K, Müller H, Busch KH, Johnsen CT, Kang NR, Lemoine NR and Halldén G (2012). Synergistic and Selective Cancer Cell Killing Mediated by the Oncolytic Adenoviral Mutant AdΔΔ and Dietary Phytochemicals in Prostate Cancer Models. Hum Gene Ther vol. 23, (9) 1003-1015. 10.1089/hum.2012.046
Botta G, Passaro C, Libertini S, Abagnale A, Barbato S, Maione AS, Hallden G, Beguinot F, Formisano P and Portella G (2012). Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo. Hum Gene Ther vol. 23, (6) 623-634. 10.1089/hum.2011.120
Sweeney KG, Cheong SC, Lemoine NR and Hallden G (2012). Abstract 2712: A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells. 10.1158/1538-7445.am2012-2712
Maya-Pineda HR, Miranda-Rota E, Lemoine NR and Halldén G (2012). Abstract 2713: Adenovirus E1A binding to p300 is essential for synergistic cell killing in combination with chemotherapeutic drugs in prostate cancer cells. 10.1158/1538-7445.am2012-2713
Halldén G (2012). Adenoviral gene expression and replication in human tumor explant models. Methods Mol Biol vol. 797, 65-78. 10.1007/978-1-61779-340-0_5
Miranda E, Maya Pineda H, Öberg D, Cherubini G, Garate Z, Lemoine NR and Halldén G (2012). Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region. Plos One vol. 7, (10) 10.1371/journal.pone.0046617
2011
Cherubini G, Kallin C, Mozetic A, Hammaren-Busch K, Müller H, Lemoine NR and Halldén G (2011). The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models. Gene Ther vol. 18, (12) 1157-1165. 10.1038/gt.2011.141
Bhattacharyya M, Francis J, Eddouadi A, Lemoine NR and Halldén G (2011). An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine. Cancer Gene Ther vol. 18, (10) 734-743. 10.1038/cgt.2011.45
Pantelidou C, Cherubini G, Lemoine NR and Hallden G (2011). Adenovirus sensitizes pancreatic cancer cells to DNA-damaging chemotherapeutics through mitotic catastrophe induction and this is further enhanced by the deletion of the anti-apoptotic E1B19K gene. Human Gene Therapy vol. 22, (10) A119-A120.
Sweeney K, Cheong SC, Lemoine N and Hallden G (2011). A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells. Human Gene Therapy vol. 22, (10) A122-A122.
Maya-Pineda H, Miranda E, Lemoine N and Hallden G (2011). Adenovirus CIA binding to p300 is essential for synergistic cell killing in combination with chemotherapeutics in prostate cancer cells. Human Gene Therapy vol. 22, (10) A104-A104.
2010
Ingemarsdotter CK, Baird SK, Connell CM, Öberg D, Halldén G and McNeish IA (2010). Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer. Oncogene vol. 29, (45) 6051-6063. 10.1038/onc.2010.335
Radhakrishnan S, Miranda E, Ekblad M, Holford A, Pizarro MT, Lemoine NR and Halldén G (2010). Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts. Hum Gene Ther vol. 21, (10) 1311-1325. 10.1089/hum.2010.019
Ekblad M and Halldén G (2010). Adenovirus-based therapy for prostate cancer. Curr Opin Mol Ther vol. 12, (4) 421-431.
Oberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR and Halldén G (2010). Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers. Clin Cancer Res vol. 16, (2) 541-553. 10.1158/1078-0432.CCR-09-1960
2009
Lee M, Choi S, Halldén G, Yo SJ, Schichnes D and Aponte GW (2009). P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion. Am J Physiol Gastrointest Liver Physiol vol. 297, (4) G641-G654. 10.1152/ajpgi.00191.2009
Hallden G (2009). Optimisation of replication-selective oncolytic adenoviral mutants in combination with chemotherapeutics. J Buon vol. 14, S61-S67.
Leitner S, Sweeney K, Oberg D, Davies D, Miranda E, Lemoine NR and Halldén G (2009). Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo. Clin Cancer Res vol. 15, (5) 1730-1740. 10.1158/1078-0432.CCR-08-2008
2008
Libertini S, Iacuzzo I, Perruolo G, Scala S, Ierano C, Franco R, Hallden G and Portella G (2008). Bevacizumab Increases Viral Distribution in Human Anaplastic Thyroid Carcinoma Xenografts and Enhances the Effects of E1A-Defective Adenovirus d/922-947. Clin Cancer Res vol. 14, (20) 6505-6514. 10.1158/1078-0432.CCR-08-0200
Bazan-Peregrino M, Carlisle RC, Hernandez-Alcoceba R, Iggo R, Homicsko K, Fisher KD, Halldén G, Mautner V, Shen Y and Seymour LW (2008). Comparison of molecular strategies for breast cancer virotherapy using oncolytic adenovirus. Hum Gene Ther vol. 19, (9) 873-886. 10.1089/hum.2008.047
Seymour LW, Bazan-Peregrino M, Carlisle R, Hernandez-Alcoceba R, Iggo R, Homicsko K, Hallden G, Mautner V, Shen J and Fisher K (2008). Comparison of Molecular Strategies for Breast Cancer Virotherapy using Oncolytic Adenovirus. Hum Gene Ther 10.1089/hgt.2008.047
Cheong SC, Wang Y, Meng J-H, Hill R, Sweeney K, Kirn D, Lemoine NR and Halldén G (2008). E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models. Cancer Gene Ther vol. 15, (1) 40-50. 10.1038/sj.cgt.7701099
2007
Gaballah K, Hills A, Curiel D, Hallden G, Harrison P and Partridge M (2007). Lysis of dysplastic but not normal oral keratinocytes and tissue-engineered epithelia with conditionally replicating adenoviruses. Cancer Res vol. 67, (15) 7284-7294. 10.1158/0008-5472.CAN-06-3834
Choi S, Lee M, Shiu AL, Yo SJ, Hallden G and Aponte GW (2007). GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Am J Physiol-Gastr L vol. 292, (5) G1366-G1375. 10.1152/ajpgi.00516.2006
2006
Bapat U, Wang Y, Alusi G, Chisholm E, Francis J, Hallden G and Lemoine N (2006). Oncolytic virotherapy for nasopharyngeal cancer. Clinical Otolaryngology vol. 31, (6) 582-583. 10.1111/j.1365-2273.2006.01341_13.x
2005
Liu T-C, Wang Y, Hallden G, Brooks G, Francis J, Lemoine NR and Kirn D (2005). Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus. Gene Ther vol. 12, (17) 1333-1346. 10.1038/sj.gt.3302555
Wang Y, Xue S-A, Hallden G, Francis J, Yuan M, Griffin BE and Lemoine NR (2005). Virus-associated RNA I-deleted adenovirus, a potential oncolytic agent targeting EBV-associated tumors. Cancer Res vol. 65, (4) 1523-1531. 10.1158/0008-5472.CAN-04-3113
Lee M, Hadi M, Halldén G and Aponte GW (2005). Peptide YY and neuropeptide Y induce villin expression, reduce adhesion, and enhance migration in small intestinal cells through the regulation of CD63, matrix metalloproteinase-3, and Cdc42 activity. J Biol Chem vol. 280, (1) 125-136. 10.1074/jbc.M408858200
Wang Y, Thorne S, Hannock J, Francis J, Au T, Reid T, Lemoine N, Kirn D and Halldén G (2005). A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses. Clin Cancer Res vol. 11, (1) 351-360. 10.1158/1078-0432.ccr-04-2548
2004
Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR and Patrick G (2004). Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite. Int J Oncol vol. 25, (1) 173-178. 10.3892/ijo.25.1.173
Liu T-C, Hallden G, Wang Y, Brooks G, Francis J, Lemoine N and Kirn D (2004). An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency. Mol Ther vol. 9, (6) 786-803. 10.1016/j.ymthe.2004.03.017
Halldén G, Thorne SH, Yang J and Kirn DH (2004). Replication-selective oncolytic adenoviruses. Methods Mol Med vol. 90, 71-90. 10.1385/1-59259-429-8:71
2003
Wang Y, Hallden G, Hill R, Anand A, Liu T-C, Francis J, Brooks G, Lemoine N and Kirn D (2003). E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models. Nat Biotechnol vol. 21, (11) 1328-1335. 10.1038/nbt887
Halldén G, Hill R, Wang Y, Anand A, Liu T-C, Lemoine NR, Francis J, Hawkins L and Kirn D (2003). Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy. Mol Ther vol. 8, (3) 412-424. 10.1016/s1525-0016(03)00199-0
2002
Kirn D, Niculescu-Duvaz I, Hallden G and Springer CJ (2002). The emerging fields of suicide gene therapy and virotherapy. Trends Mol Med vol. 8, (4 Suppl) S68-S73. 10.1016/s1471-4914(02)02318-3
1994
Hallden G, Holehouse EL, Dong X and Aponte GW (1994). Expression of intestinal fatty acid binding protein in intestinal epithelial cell lines, hBRIE 380 cells. American Journal of Physiology - Gastrointestinal and Liver Physiology vol. 267, (4 30-4) 10.1152/ajpgi.1994.267.4.g730
1989
Mulvihill SJ, Hallden G and Debas HT (1989). Trophic effect of amniotic fluid on cultured fetal gastric mucosal cells. Journal of Surgical Research vol. 46, (4) 327-329. 10.1016/0022-4804(89)90196-0
Szecowka J, Hallden G, Goldfine ID and Williams JA (1989). Purification of the pancreatic cholecystokinin receptor. Regulatory Peptides vol. 24, (3) 215-224. 10.1016/0167-0115(89)90218-8