Publications

Publications of specific relevance to Predictive in vitro Models
2022

Vivaldi G, Jolliffe DA, Faustini S, Shields AM, Holt H, Perdek N, Talaei M, Tydeman F,
Chambers ES, Cai W, Li W, Gibbons JM, Pade C, McKnight Á, Shaheen SO, Richter AG and
Martineau AR (2022).
Correlation between Postvaccination Anti-Spike Antibody Titers and Protection against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study. Journal of Infectious Diseases vol. 226, (11) 1903-1908.
10.1093/infdis/jiac321
Jolliffe DA, Vivaldi G,
Chambers ES, Cai W, Li W, Faustini SE, Gibbons JM, Pade C, Coussens AK, Richter AG, McKnight Á and
Martineau AR (2022).
Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial. Nutrients vol. 14, (18)
10.3390/nu141838212021

Fiard G, Stavrinides V,
Chambers ES, Heavey S, Freeman A, Ball R, Akbar AN and Emberton M (2021).
Cellular senescence as a possible link between prostate diseases of the ageing male. Nature Reviews Urology vol. 18, (10) 597-610.
10.1038/s41585-021-00496-8
Zou J, Thornton C,
Chambers ES, Rosser EC and Ciurtin C (2021).
Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease. Frontiers in Immunology vol. 11,
10.3389/fimmu.2020.616483
Chambers E, Vukmanovic-Stejic M, Shih B, Subramanian P, Devine OP, Glanville J, Gilroy D, Rustin M, Freeman TC, Mabbott N and Akbar AN (2021).
Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging. Nature Aging 101-113.
10.1038/s43587-020-00010-62020
Chambers E, Vukmanovic-Stejic M, Turner C, Shih B, Trahair H, Pollara G, Tsaliki E, Rustin M, Freeman T, Mabbott N, Noursadeghi M,
Martineau A and Akbar A (2020).
Vitamin D3 replacement enhances antigen-specific immunity in older adults. Immunotherapy Advances 1-1.
10.1093/immadv/ltaa008
Pereira B, De Maeyer R, Covre L, Nehar-Belaid D, Lanna A, Ward S, Marches R,
Chambers E, Gomes D, Riddell N, Maini M, Teixeira V, Janes S, Gilroy D, Larbi A, Mabbott N, Ucar D, Kuchel G, Henson S, Strid J, Lee J, Banchereau J and Akbar A (2020).
Sestrins induce natural killer function in 1 senescent-like CD8+ T cells. Nature Immunology 10.1038/s41590-020-0643-32019

Pereira BI, Devine OP, Vukmanovic-Stejic M,
Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ, Passos JF, Antoniou A, Rustin MHA, Campisi J and Akbar AN (2019).
Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Nature Communications vol. 10, (1)
10.1038/s41467-019-10335-5
Covre LP, Martins RF, Devine OP,
Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR, de Matos Guedes HL, Falqueto A, Akbar AN and Gomes DCO (2019).
Circulating senescent T cells are linked to systemic inflammation and lesion size during human cutaneous leishmaniasis. Frontiers in Immunology vol. 10, (JAN)
10.3389/fimmu.2018.030012018

Patel NP, Vukmanovic-Stejic M, Suarez-Farinas M,
Chambers ES, Sandhu D, Fuentes-Duculan J, Mabbott NA, Rustin MHA, Krueger J and Akbar AN (2018).
Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge. J Infect Dis vol. 218, (suppl_2) S88-S98.
10.1093/infdis/jiy420
Vukmanovic-Stejic M,
Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE, Turner CT, Larbi A, Birault V, Noursadeghi M, Mabbott NA, Rustin MHA, Krueger JG and Akbar AN (2018).
Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation. Journal of Allergy and Clinical Immunology vol. 142, (3) 844-856.
10.1016/j.jaci.2017.10.032
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF,
Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2018).
Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids. Clinical and Experimental Allergy vol. 48, (1) 13-22.
10.1111/cea.130612017

Callender LA, carroll EC, beal R,
Chambers ES, Nourshargh S, Akbar AN and Henson SM (2017).
Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK. Wiley Open Access Aging Cell 10.1111/acel.126752015

Mann EH,
Chambers ES, Chen YH, Richards DF and Hawrylowicz CM (2015).
1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3- T cells. Immunology vol. 146, (3) 423-431.
10.1111/imm.12519
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM,
Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2015).
Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol. Journal of Allergy and Clinical Immunology vol. 136, (3) 628-637.e4.
10.1016/j.jaci.2015.01.0262014

Pfeffer PE, Mann EH, Hornsby E,
Chambers ES, Chen YH, Rice L and Hawrylowicz CM (2014).
Vitamin D influences asthmatic pathology through its action on diverse immunological pathways. Annals of The American Thoracic Society vol. 11, S314-S321.
10.1513/AnnalsATS.201405-204AW
Nanzer AM,
Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, Timms PM,
Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2014).
The effects of calcitriol treatment in glucocorticoid-resistant asthma. Journal of Allergy and Clinical Immunology 10.1016/j.jaci.2014.03.015
Mann EH,
Chambers ES, Pfeffer PE and Hawrylowicz CM (2014).
Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Annals of The New York Academy of Sciences vol. 1317, (1) 57-69.
10.1111/nyas.12410
Chambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G and Hawrylowicz CM (2014).
1α,25-dihydroxyvitamin D3 in combination with transforming growth factor-β increases the frequency of Foxp3+ regulatory T cells through preferential expansion and usage of interleukin-2. Immunology vol. 143, (1) 52-60.
10.1111/imm.12289
Gupta A, Dimeloe S, Richards DF,
Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E, Bush A, Saglani S and Hawrylowicz CM (2014).
Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Thorax vol. 69, (6) 508-515.
10.1136/thoraxjnl-2013-2034212013

Nanzer AM,
Chambers ES, Ryanna K, Richards DF, Black C, Timms PM,
Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2013).
Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol vol. 132, (2) 297-304.e3.
10.1016/j.jaci.2013.03.0372012

Urry Z,
Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A, Saglani S, Bush A, O'Garra A, Brown Z and Hawrylowicz CM (2012).
The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL-10+ CD4+ T cells. European Journal of Immunology vol. 42, (10) 2697-2708.
10.1002/eji.201242370
Chambers ES, Nanzer AM, Richards DF, Ryanna K, Freeman AT, Timms PM,
Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2012).
Serum 25-dihydroxyvitamin D levels correlate with CD4(+)Foxp3(+) T-cell numbers in moderate/severe asthma. Journal of Allergy and Clinical Immunology vol. 130, (2) 542-544.
10.1016/j.jaci.2012.04.0222011