Dr Emma Chambers
Lecturer
Centre for Immunobiology, Blizard Institute
Queen Mary University of London
Queen Mary University of London
Research
Ageing, Senescence, Lung, Asthma, Immunology, Immunosenescence
Interests
I have an interest in the ageing lung in health and disease (asthma). Current organ-on-a-chip models tend to use younger cells to generate the model - meaning the current models don't recapitulate older tissue. Therefore, the aim of my lab is to generate old and young lung organ-on-a-chip models to assess the impact of aged lungs on immunity to infection.We are using the QMUL+EMULATE Centre to generate senescent (Old) and non-senescent (young) alveolar lung chips to investigate the impact of senescence on immune cell phenotype and function. Using this exciting technology I will be able to dissect if the increase in senescent cells seen with age in the lung, is responsible for impaired anti-pathogen immunity observed in older adults and their increased susceptibility to viral (such as SARs-CoV-2 and Influenza) and bacterial (such a pneumonia) lung disease.
Long terms aim of this work is to transfer this technique to other tissue-on-chip situations to assess the impact of senescence across the body in health and disease.
Publications
2025

Littlewood K, Gegic J, Hickman M, Henson RCJ, Bishop JR, Kershaw T, Diamond P, Slabaugh G et al.
Aging Clinical and Experimental Research, Springer Science and Business Media Llc vol. 37 (1)
23-06-2025

De Maeyer RPH, Sikora J, Bracken OV, Shih B, Lloyd AF, Peckham H, Hollett K, Abdelhamid K et al.
In Cold Spring Harbor Laboratory
01-04-2025

Peckham H, Radziszewska A, Sikora J, de Gruijter NM, Restuadi R, Kartawinata M, Martin-Gutierrez L, Robinson GA et al.
Journal of Experimental Medicine, Rockefeller University Press vol. 222 (4)
06-03-2025

Hindle SA, Bachas Brook H, Chrysanthou A, Chambers ES, Caley MP, Connelly JT
Advanced Science, Wiley vol. 12 (10)
21-01-2025

Kalailingam P, Ngan SC, Iyappan R, Nehchiri A, Mohd‐Kahliab K, Lee BST, Sharma B, Machan R et al.
Aging Cell, Wiley vol. 24 (4)
05-01-2025
2024

Hindle SA, Brook HB, Chrysanthou A, Chambers ES, Caley MP, Connelly JT
In Cold Spring Harbor Laboratory
17-11-2024

Subramanian P, Sayegh S, Laphanuwat P, Devine OP, Fantecelle CH, Sikora J, Chambers ES, Karagiannis SN et al.
Aging Cell, Wiley vol. 24 (2)
17-10-2024

Human Antibodies, Sage Publications vol. 32 (3), 121-128.
24-07-2024

Chambers ES, Cai W, Vivaldi G, Jolliffe DA, Perdek N, Li W, Faustini SE, Gibbons JM et al.
Npj Vaccines, Springer Science and Business Media Llc vol. 9 (1)
22-05-2024

Sayegh S, Fantecelle CH, Laphanuwat P, Subramanian P, Rustin MHA, Gomes DCO, Akbar AN, Chambers ES
Aging Cell, Wiley vol. 23 (4)
29-01-2024
2023

Chambers ES, Cai W, Vivaldi G, Jolliffe DA, Perdek N, Li W, Faustini SE, Gibbons JM et al.
In Cold Spring Harbor Laboratory
29-09-2023

Kalailingam P, Mohd-Kahliab K-H, Ngan SC, Iyappan R, Lee BST, Sharma B, Machan R, Bo ST et al.
In Cold Spring Harbor Laboratory
14-08-2023
2022

Jolliffe DA, Vivaldi G, Chambers ES, Cai W, Li W, Faustini SE, Gibbons JM, Pade C et al.
Nutrients, Mdpi Ag vol. 14 (18), 3821-3821.
16-09-2022

Vivaldi G, Jolliffe DA, Faustini S, Shields AM, Holt H, Perdek N, Talaei M, Tydeman F et al.
The Journal of Infectious Diseases, Oxford University Press (Oup) vol. 226 (11), 1903-1908.
30-07-2022

Jolliffe DA, Vivaldi G, Chambers ES, Cai W, Li W, Faustini SE, Gibbons JM, Pade C et al.
In Cold Spring Harbor Laboratory
17-07-2022

Vivaldi G, Jolliffe DA, Faustini S, Holt H, Perdek N, Talaei M, Tydeman F, Chambers ES et al.
In Cold Spring Harbor Laboratory
13-02-2022
2021

Fiard G, Stavrinides V, Chambers ES, Heavey S, Freeman A, Ball R, Akbar AN, Emberton M
Nature Reviews Urology, Springer Science and Business Media Llc vol. 18 (10), 597-610.
22-07-2021

Zou J, Thornton C, Chambers ES, Rosser EC, Ciurtin C
Frontiers in Immunology, Frontiers Media Sa vol. 11
18-02-2021

De Maeyer RPH, Chambers ES
Immunology Letters, Elsevier Bv vol. 230, 1-10.
01-02-2021

Chambers ES, Vukmanovic-Stejic M, Shih BB, Trahair H, Subramanian P, Devine OP, Glanville J, Gilroy D et al.
Nature Aging, Springer Science and Business Media Llc vol. 1 (1), 101-113.
14-01-2021
2020

Chambers ES, Vukmanovic-Stejic M, Turner CT, Shih BB, Trahair H, Pollara G, Tsaliki E, Rustin M et al.
Immunotherapy Advances, Oxford University Press (Oup) vol. 1 (1)
25-11-2020

Chambers ES, Akbar AN
Journal of Allergy and Clinical Immunology, Elsevier Bv vol. 145 (5), 1323-1331.
01-05-2020

Chambers ES, Vukmanovic-Stejic M, Shih BB, Trahair H, Subramanian P, Devine OP, Glanville J, Gilroy D et al.
In Cold Spring Harbor Laboratory
03-04-2020

Pereira BI, De Maeyer RPH, Covre LP, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers ES et al.
Nature Immunology, Springer Science and Business Media Llc vol. 21 (6), 684-694.
30-03-2020
2019

Chambers ES, Vukmanovic‐Stejic M
Immunology, Wiley vol. 160 (2), 116-125.
04-12-2019

Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ et al.
Nature Communications, Springer Science and Business Media Llc vol. 10 (1)
03-06-2019

Covre LP, Martins RF, Devine OP, Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR et al.
Frontiers in Immunology, Frontiers Media Sa vol. 9
04-01-2019
2018

Patel NP, Vukmanovic-Stejic M, Suarez- Farinas M, Chambers ES, Sandhu D, Fuentes-Duculan J, Mabbott NA, Rustin MHA et al.
The Journal of Infectious Diseases, Oxford University Press (Oup) vol. 218 (suppl_2), S88-S98.
22-09-2018

Vukmanovic-Stejic M, Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE et al.
Journal of Allergy and Clinical Immunology, Elsevier Bv vol. 142 (3), 844-856.
01-09-2018
2017

Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ, Hawrylowicz CM
Clinical &Amp; Experimental Allergy, Wiley vol. 48 (1), 13-22.
18-12-2017
2016

Chambers ES, Devine O, Patel N, Mabbot N, Vukmanovic-Stejic M, Akbar AN
01-01-2016
2015

Mann EH, Chambers ES, Chen Y, Richards DF, Hawrylowicz CM
Immunology, Wiley vol. 146 (3), 423-431.
13-09-2015

Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ et al.
Journal of Allergy and Clinical Immunology, Elsevier Bv vol. 136 (3), 628-637.e4.
01-09-2015
2014

Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen Y-H, Rice L, Hawrylowicz CM
Annals of The American Thoracic Society, American Thoracic Society vol. 11 (Supplement 5), S314-S321.
01-12-2014

Chambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G, Hawrylowicz CM
Immunology, Wiley vol. 143 (1), 52-60.
29-07-2014

Nanzer AM, Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, Timms PM, Martineau AR et al.
Journal of Allergy and Clinical Immunology, Elsevier Bv vol. 133 (6), 1755-1757.e4.
01-06-2014

Mann EH, Chambers ES, Pfeffer PE, Hawrylowicz CM
Annals of The New York Academy of Sciences, Wiley vol. 1317 (1), 57-69.
16-04-2014

Nanzer AM, Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, Timms PM, Martineau AR et al.
Journal of Allergy and Clinical Immunology vol. 133 (6), 1755-1757.
01-01-2014

Mann EH, Chambers ES, Nanzer AM, Richards DF, Hawrylowicz CM
01-01-2014
2013

Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E et al.
Thorax, Bmj vol. 69 (6), 508-515.
17-12-2013

Nanzer AM, Chambers ES, Richards DF, Martineau AR, Griffiths CJ, Corrigan C, Hawrylowicz CM
14-11-2013

Nanzer AM, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM, Martineau AR, Griffiths CJ et al.
Journal of Allergy and Clinical Immunology, Elsevier Bv vol. 132 (2), 297-304.e3.
01-08-2013
2012

Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A et al.
European Journal of Immunology, Wiley vol. 42 (10), 2697-2708.
20-08-2012

Chambers ES, Nanzer AM, Richards DF, Ryanna K, Freeman AT, Timms PM, Martineau AR, Griffiths CJ et al.
Journal of Allergy and Clinical Immunology, Elsevier Bv vol. 130 (2), 542-544.
01-08-2012
2011

Chambers ES, Nanzer AM, Richards DF, Freeman A, Ryanna K, Griffiths C, Corrigan CJ, Hawrylowicz CM
01-01-2011

Nanzer AM, Chambers ES, Richards DF, Timms PM, Martineau AR, Corrigan CJ, Griffiths CJ, Hawrylowicz CM
01-01-2011

Nanzer AM, Chambers ES, Ryanna K, Richards DF, Freeman A, Martineau AR, Xystrakis E, Corrigan CJ et al.
01-01-2011
2010

Chambers ES, Nanzer A, Richards DF, Freeman A, Ryanna K, Dimeloe SK, Griffiths C, Corrigan C et al.
01-12-2010

Chambers ES, Hawrylowicz CM
Current Allergy and Asthma Reports, Springer Science and Business Media Llc vol. 11 (1), 29-36.
23-11-2010

HENSON SM, Callender LA, Carroll EC, Beal RWJ, Chamber ES, Nourshargh S, Akbar AN
Aging Cell, Wiley Open Access
Grants

Emma Chambers
£74,878 Barts and the London Charity
01-09-2024 - 01-12-2025

Emma Chambers, Emanuel Rognoni and Matthew Caley
£139,912 DEBRA UK
01-04-2024 - 31-03-2028

Emma Chambers
£47,230 DMT Dunhill Medical Trust, The
01-04-2022 - 01-09-2023