Close

We use cookies to improve your experience of our website. Privacy Policy

Skip to main content
Menu

Dr Emma Chambers

Emma Chambers

Lecturer

Centre for Immunobiology, Blizard Institute
Queen Mary University of London

ORCiD LinkedIn Twitter

Research

ageing, senescence, lung, asthma, immunology, immunosenescence

Interests

I have an interest in the ageing lung in health and disease - using the QMUL+EMULATE Centre I am generating senescent (Old) and non-senescent (young) alveolar lung chips to investigate the impact of senescence on immune cell phenotype and function. Using this exciting technology I will be able to dissect if the increase in senescent cells seen with age in the lung, is responsible for impaired anti-pathogen immunity observed in older adults. It is anticipated that this technique will be transferable to other tissue-on-chip situations to assess the impact of senescence across the body in health and disease.

Publications

Publications of specific relevance to Predictive in vitro Models

2021

Zou J, Thornton C, Chambers ES, Rosser EC and Ciurtin C (2021). Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease. Frontiers in Immunology  vol. 11, 10.3389/fimmu.2020.616483
Chambers E, Vukmanovic-Stejic M, Shih B, Subramanian P, Devine OP, Glanville J, Gilroy D, Rustin M, Freeman TC, Mabbott N and Akbar AN (2021). Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging. Nature Aging  101-113. 10.1038/s43587-020-00010-6

2020

Chambers E (2020). The impact of ageing on monocytes and macrophages. Elsevier  Immunology Letters  10.1016/j.imlet.2020.12.003
Chambers E, Vukmanovic-Stejic M, Turner C, Shih B, Trahair H, Pollara G, Tsaliki E, Rustin M, Freeman T, Mabbott N, Noursadeghi M, Martineau A and Akbar A (2020). Vitamin D3 replacement enhances antigen-specific immunity in older adults. Immunotherapy Advances  1-1. 10.1093/immadv/ltaa008
Chambers ES and Akbar AN (2020). Reply. Journal of Allergy and Clinical Immunology  vol. 146, (4) 922-923. 10.1016/j.jaci.2020.06.020
Chambers ES and Vukmanovic-Stejic M (2020). Skin barrier immunity and ageing. Immunology  vol. 160, (2) 116-125. 10.1111/imm.13152
Chambers ES and Akbar AN (2020). Can blocking inflammation enhance immunity during aging? Journal of Allergy and Clinical Immunology  vol. 145, (5) 1323-1331. 10.1016/j.jaci.2020.03.016
Pereira B, De Maeyer R, Covre L, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers E, Gomes D, Riddell N, Maini M, Teixeira V, Janes S, Gilroy D, Larbi A, Mabbott N, Ucar D, Kuchel G, Henson S, Strid J, Lee J, Banchereau J and Akbar A (2020). Sestrins induce natural killer function in 1 senescent-like CD8+ T cells. Nature Immunology  10.1038/s41590-020-0643-3

2019

Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ, Passos JF, Antoniou A, Rustin MHA, Campisi J and Akbar AN (2019). Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Nature Communications  vol. 10, (1) 10.1038/s41467-019-10335-5
Covre LP, Martins RF, Devine OP, Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR, de Matos Guedes HL, Falqueto A, Akbar AN and Gomes DCO (2019). Circulating senescent T cells are linked to systemic inflammation and lesion size during human cutaneous leishmaniasis. Frontiers in Immunology  vol. 10, (JAN) 10.3389/fimmu.2018.03001

2018

Patel NP, Vukmanovic-Stejic M, Suarez-Farinas M, Chambers ES, Sandhu D, Fuentes-Duculan J, Mabbott NA, Rustin MHA, Krueger J and Akbar AN (2018). Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge. J Infect Dis  vol. 218, (suppl_2) S88-S98. 10.1093/infdis/jiy420
Vukmanovic-Stejic M, Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE, Turner CT, Larbi A, Birault V, Noursadeghi M, Mabbott NA, Rustin MHA, Krueger JG and Akbar AN (2018). Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation. Journal of Allergy and Clinical Immunology  vol. 142, (3) 844-856. 10.1016/j.jaci.2017.10.032
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2018). Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids. Clinical and Experimental Allergy  vol. 48, (1) 13-22. 10.1111/cea.13061

2017

Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN and Henson SM (2017). Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK. Wiley Open Access  Aging Cell  10.1111/acel.12675

2015

Mann EH, Chambers ES, Chen YH, Richards DF and Hawrylowicz CM (2015). 1α,25-dihydroxyvitamin D3 acts via transforming growth factor-β to up-regulate expression of immunosuppressive CD73 on human CD4+ Foxp3- T cells. Immunology  vol. 146, (3) 423-431. 10.1111/imm.12519
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2015). Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol. Journal of Allergy and Clinical Immunology  vol. 136, (3) 628-637.e4. 10.1016/j.jaci.2015.01.026

2014

Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen YH, Rice L and Hawrylowicz CM (2014). Vitamin D influences asthmatic pathology through its action on diverse immunological pathways. Annals of The American Thoracic Society  vol. 11, S314-S321. 10.1513/AnnalsATS.201405-204AW
Nanzer AM, Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2014). The effects of calcitriol treatment in glucocorticoid-resistant asthma. Journal of Allergy and Clinical Immunology  10.1016/j.jaci.2014.03.015
Mann EH, Chambers ES, Pfeffer PE and Hawrylowicz CM (2014). Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Annals of The New York Academy of Sciences  vol. 1317, (1) 57-69. 10.1111/nyas.12410
Chambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G and Hawrylowicz CM (2014). 1α,25-dihydroxyvitamin D3 in combination with transforming growth factor-β increases the frequency of Foxp3+ regulatory T cells through preferential expansion and usage of interleukin-2. Immunology  vol. 143, (1) 52-60. 10.1111/imm.12289
Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E, Bush A, Saglani S and Hawrylowicz CM (2014). Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Thorax  vol. 69, (6) 508-515. 10.1136/thoraxjnl-2013-203421

2013

Nanzer AM, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2013). Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. Journal of Allergy and Clinical Immunology  vol. 132, (2) 10.1016/j.jaci.2013.03.037

2012

(2012). The role of 1α,25-dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL-10+ CD4+ T cells. European Journal of Immunology  vol. 42, (10) 2697-2708. 10.1002/eji.201242370
Chambers ES, Nanzer AM, Richards DF, Ryanna K, Freeman AT, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2012). Serum 25-dihydroxyvitamin D levels correlate with CD4(+)Foxp3(+) T-cell numbers in moderate/severe asthma. J Allergy Clin Immunol  vol. 130, (2) 542-544. 10.1016/j.jaci.2012.04.022

2011

Chambers ES and Hawrylowicz CM (2011). The impact of vitamin D on regulatory T cells. Current Allergy and Asthma Reports  vol. 11, (1) 29-36. 10.1007/s11882-010-0161-8

Grants

Grants of specific relevance to Predictive in vitro Models
Mechanisms involved in decreased cutaneous immunity during ageing: reversal by Vitamin D pre-treatment.
Chambers ES
Leo Foundation (01-06-2020 - 31-05-2023)
Bart's Charity Lectureship
Chambers ES
Bart's Charity (14-04-2020 - 13-04-2023)