Dr Emma Chambers
Lecturer
Centre for Immunobiology, Blizard Institute
Queen Mary University of London
Queen Mary University of London
Research
Ageing, Senescence, Lung, Asthma, Immunology, Immunosenescence
Interests
I have an interest in the ageing lung in health and disease (asthma). Current organ-on-a-chip models tend to use younger cells to generate the model - meaning the current models don't recapitulate older tissue. Therefore, the aim of my lab is to generate old and young lung organ-on-a-chip models to assess the impact of aged lungs on immunity to infection. We are using the QMUL+EMULATE Centre to generate senescent (Old) and non-senescent (young) alveolar lung chips to investigate the impact of senescence on immune cell phenotype and function. Using this exciting technology I will be able to dissect if the increase in senescent cells seen with age in the lung, is responsible for impaired anti-pathogen immunity observed in older adults and their increased susceptibility to viral (such as SARs-CoV-2 and Influenza) and bacterial (such a pneumonia) lung disease. Long terms aim of this work is to transfer this technique to other tissue-on-chip situations to assess the impact of senescence across the body in health and disease.Publications
2024
Sayegh S, Fantecelle CH, Laphanuwat P, Subramanian P, Rustin MHA, Gomes DCO, Akbar AN and Chambers ES (2024). Vitamin D3 inhibits p38 MAPK and senescence‐associated inflammatory mediator secretion by senescent fibroblasts that impacts immune responses during ageing. Wiley Aging Cell 10.1111/acel.140932022
Jolliffe DA, Vivaldi G, Chambers ES, Cai W, Li W, Faustini SE, Gibbons JM, Pade C, Coussens AK, Richter AG, McKnight Á and Martineau AR (2022). Vitamin D Supplementation Does Not Influence SARS-CoV-2 Vaccine Efficacy or Immunogenicity: Sub-Studies Nested within the CORONAVIT Randomised Controlled Trial. Mdpi Nutrients vol. 14, (18) 10.3390/nu14183821Vivaldi G, Jolliffe DA, Faustini S, Shields AM, Holt H, Perdek N, Talaei M, Tydeman F, Chambers ES, Cai W, Li W, Gibbons JM, Pade C, McKnight Á, Shaheen SO, Richter AG and Martineau AR (2022). Correlation Between Postvaccination Anti-Spike Antibody Titers and Protection Against Breakthrough Severe Acute Respiratory Syndrome Coronavirus 2 Infection: A Population-Based Longitudinal Study. Oxford University Press (Oup) The Journal of Infectious Diseases vol. 226, (11) 1903-1908. 10.1093/infdis/jiac3212021
Fiard G, Stavrinides V, Chambers ES, Heavey S, Freeman A, Ball R, Akbar AN and Emberton M (2021). Cellular senescence as a possible link between prostate diseases of the ageing male. Springer Nature Nature Reviews Urology vol. 18, (10) 597-610. 10.1038/s41585-021-00496-8Zou J, Thornton C, Chambers ES, Rosser EC and Ciurtin C (2021). Exploring the Evidence for an Immunomodulatory Role of Vitamin D in Juvenile and Adult Rheumatic Disease. Frontiers Frontiers in Immunology vol. 11, 10.3389/fimmu.2020.616483Chambers E, Vukmanovic-Stejic M, Shih B, Subramanian P, Devine OP, Glanville J, Gilroy D, Rustin M, Freeman TC, Mabbott N and Akbar AN (2021). Recruitment of inflammatory monocytes by senescent fibroblasts inhibits antigen-specific tissue immunity during human aging. Nature Aging 101-113. 10.1038/s43587-020-00010-62020
Chambers E (2020). The impact of ageing on monocytes and macrophages. Elsevier Immunology Letters 10.1016/j.imlet.2020.12.003Chambers E, Vukmanovic-Stejic M, Turner C, Shih B, Trahair H, Pollara G, Tsaliki E, Rustin M, Freeman T, Mabbott N, Noursadeghi M, Martineau A and Akbar A (2020). Vitamin D3 replacement enhances antigen-specific immunity in older adults. Immunotherapy Advances 1-1. 10.1093/immadv/ltaa008Chambers ES and Akbar AN (2020). Reply. Journal of Allergy and Clinical Immunology vol. 146, (4) 922-923. 10.1016/j.jaci.2020.06.020Chambers ES and Akbar AN (2020). Can blocking inflammation enhance immunity during aging? Journal of Allergy and Clinical Immunology vol. 145, (5) 1323-1331. 10.1016/j.jaci.2020.03.016Pereira B, De Maeyer R, Covre L, Nehar-Belaid D, Lanna A, Ward S, Marches R, Chambers E, Gomes D, Riddell N, Maini M, Teixeira V, Janes S, Gilroy D, Larbi A, Mabbott N, Ucar D, Kuchel G, Henson S, Strid J, Lee J, Banchereau J and Akbar A (2020). Sestrins induce natural killer function in 1 senescent-like CD8+ T cells. Nature Immunology 10.1038/s41590-020-0643-32019
Chambers ES and Vukmanovic‐Stejic M (2019). Skin barrier immunity and ageing. Wiley Immunology vol. 160, (2) 116-125. 10.1111/imm.13152Pereira BI, Devine OP, Vukmanovic-Stejic M, Chambers ES, Subramanian P, Patel N, Virasami A, Sebire NJ, Kinsler V, Valdovinos A, LeSaux CJ, Passos JF, Antoniou A, Rustin MHA, Campisi J and Akbar AN (2019). Senescent cells evade immune clearance via HLA-E-mediated NK and CD8+ T cell inhibition. Springer Nature Nature Communications vol. 10, (1) 10.1038/s41467-019-10335-5Covre LP, Martins RF, Devine OP, Chambers ES, Vukmanovic-Stejic M, Silva JA, Dietze R, Rodrigues RR, de Matos Guedes HL, Falqueto A, Akbar AN and Gomes DCO (2019). Circulating Senescent T Cells Are Linked to Systemic Inflammation and Lesion Size During Human Cutaneous Leishmaniasis. Frontiers Frontiers in Immunology vol. 9, 10.3389/fimmu.2018.030012018
Patel NP, Vukmanovic-Stejic M, Suarez-Farinas M, Chambers ES, Sandhu D, Fuentes-Duculan J, Mabbott NA, Rustin MHA, Krueger J and Akbar AN (2018). Impact of Zostavax Vaccination on T-Cell Accumulation and Cutaneous Gene Expression in the Skin of Older Humans After Varicella Zoster Virus Antigen-Specific Challenge. J Infect Dis vol. 218, (suppl_2) S88-S98. 10.1093/infdis/jiy4202017
Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2017). Dendritic cell phenotype in severe asthma reflects clinical responsiveness to glucocorticoids. Wiley Clinical & Experimental Allergy vol. 48, (1) 13-22. 10.1111/cea.13061Vukmanovic-Stejic M, Chambers ES, Suárez-Fariñas M, Sandhu D, Fuentes-Duculan J, Patel N, Agius E, Lacy KE, Turner CT, Larbi A, Birault V, Noursadeghi M, Mabbott NA, Rustin MHA, Krueger JG and Akbar AN (2017). Enhancement of cutaneous immunity during aging by blocking p38 mitogen-activated protein (MAP) kinase–induced inflammation. Elsevier Journal of Allergy and Clinical Immunology vol. 142, (3) 844-856. 10.1016/j.jaci.2017.10.032Callender LA, carroll EC, beal R, Chambers ES, Nourshargh S, Akbar AN and Henson SM (2017). Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK. Wiley Open Access Aging Cell 10.1111/acel.126752015
Mann EH, Chambers ES, Chen Y-H, Richards DF and Hawrylowicz CM (2015). 1α,25‐dihydroxyvitamin D3 acts via transforming growth factor‐β to up‐regulate expression of immunosuppressive CD73 on human CD4+ Foxp3– T cells. Wiley Immunology vol. 146, (3) 423-431. 10.1111/imm.12519Chambers ES, Nanzer AM, Pfeffer PE, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2015). Distinct endotypes of steroid-resistant asthma characterized by IL-17Ahigh and IFN-γhigh immunophenotypes: Potential benefits of calcitriol. Elsevier Journal of Allergy and Clinical Immunology vol. 136, (3) 628-637.e4. 10.1016/j.jaci.2015.01.0262014
Pfeffer PE, Mann EH, Hornsby E, Chambers ES, Chen Y-H, Rice L and Hawrylowicz CM (2014). Vitamin D Influences Asthmatic Pathology through Its Action on Diverse Immunological Pathways. American Thoracic Society Annals of The American Thoracic Society vol. 11, (Supplement 5) s314-s321. 10.1513/annalsats.201405-204awChambers ES, Suwannasaen D, Mann EH, Urry Z, Richards DF, Lertmemongkolchai G and Hawrylowicz CM (2014). 1α,25‐dihydroxyvitamin D3 in combination with transforming growth factor‐β increases the frequency of Foxp3+ regulatory T cells through preferential expansion and usage of interleukin‐2. Wiley Immunology vol. 143, (1) 52-60. 10.1111/imm.12289Mann EH, Chambers ES, Pfeffer PE and Hawrylowicz CM (2014). Immunoregulatory mechanisms of vitamin D relevant to respiratory health and asthma. Wiley Annals of The New York Academy of Sciences vol. 1317, (1) 57-69. 10.1111/nyas.12410Nanzer AM, Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2014). The effects of calcitriol treatment in glucocorticoid-resistant asthma. Journal of Allergy and Clinical Immunology 10.1016/j.jaci.2014.03.015Nanzer AM, Chambers ES, Ryanna K, Freeman AT, Colligan G, Richards DF, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2014). The effects of calcitriol treatment in glucocorticoid-resistant asthma. Journal of Allergy and Clinical Immunology vol. 133, (6) 10.1016/j.jaci.2014.03.0152013
Gupta A, Dimeloe S, Richards DF, Chambers ES, Black C, Urry Z, Ryanna K, Xystrakis E, Bush A, Saglani S and Hawrylowicz CM (2013). Defective IL-10 expression and in vitro steroid-induced IL-17A in paediatric severe therapy-resistant asthma. Bmj Thorax vol. 69, (6) 10.1136/thoraxjnl-2013-203421Nanzer AM, Chambers ES, Ryanna K, Richards DF, Black C, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2013). Enhanced production of IL-17A in patients with severe asthma is inhibited by 1α,25-dihydroxyvitamin D3 in a glucocorticoid-independent fashion. J Allergy Clin Immunol vol. 132, (2) 297-304.e3. 10.1016/j.jaci.2013.03.0372012
Urry Z, Chambers ES, Xystrakis E, Dimeloe S, Richards DF, Gabryšová L, Christensen J, Gupta A, Saglani S, Bush A, O'Garra A, Brown Z and Hawrylowicz CM (2012). The role of 1α,25‐dihydroxyvitamin D3 and cytokines in the promotion of distinct Foxp3+and IL‐10+ CD4+ T cells. Wiley European Journal of Immunology vol. 42, (10) 2697-2708. 10.1002/eji.201242370Chambers ES, Nanzer AM, Richards DF, Ryanna K, Freeman AT, Timms PM, Martineau AR, Griffiths CJ, Corrigan CJ and Hawrylowicz CM (2012). Serum 25-dihydroxyvitamin D levels correlate with CD4+Foxp3+ T-cell numbers in moderate/severe asthma. Journal of Allergy and Clinical Immunology vol. 130, (2) 542-544. 10.1016/j.jaci.2012.04.0222010
Chambers ES and Hawrylowicz CM (2010). The Impact of Vitamin D on Regulatory T Cells. Springer Nature Current Allergy and Asthma Reports vol. 11, (1) 29-36. 10.1007/s11882-010-0161-8Grants
Grants of specific relevance to Predictive in vitro Models
Mechanisms involved in decreased cutaneous immunity during ageing: reversal by Vitamin D pre-treatment.Chambers ES
Leo Foundation (01-06-2020 - 31-05-2023)
The Effect Of Age On Monocyte Phenotype And FunctionChambers ES
£47,230 Dunhill Medical Trust (01-05-2022 - 30-04-2023)
