Dr Diana Blaydon
Non-clinical Lecturer
Centre for Cell Biology and Cutaneous Research
Blizard Institute
Blizard Institute
Research
Skin, Epidermal barrier, Monogenic skin conditions, Cell-cell adhesion, 3D models
Interests
Using patient-derived, mutant keratinocytes in monolayer and 3D organotypic skin models to study molecular mechanisms underlying epidermal barrier function.Publications
2024
Dulloo I, Tellier M, Levet C, Chikh A, Zhang B, Blaydon DC, Webb CM, Kelsell DP and Freeman M (2024). Cleavage of the pseudoprotease iRhom2 by the signal peptidase complex reveals an ER-to-nucleus signaling pathway. Elsevier Molecular Cell vol. 84, (2) 277-292.e9. 10.1016/j.molcel.2023.12.012
2023
Murtough S, Babu D, Webb CM, Picard HLD, McGinty LA, Chao-Chu J, Pink R, Silver AR, Smart HL, Field JK, Woodland P, Risk JM, Blaydon DC, Pennington DJ and Kelsell DP (2023). INVESTIGATING iRHOM2-ASSOCIATED TRANSCRIPTIONAL CHANGES IN TYLOSIS WITH ESOPHAGEAL CANCER. Elsevier Gastro Hep Advances 10.1016/j.gastha.2023.12.007
Ustaoglu A, Daudali FA, D’afflitto M, Murtough S, Lee C, Moreno E, Blaydon DC, Kelsell DP, Sifrim D, Woodland P and Peiris M (2023). Identification of novel immune cell signature in gastroesophageal reflux disease: altered mucosal mast cells and dendritic cell profile. Frontiers Frontiers in Immunology vol. 14, 10.3389/fimmu.2023.1282577
2020
Chao-Chu J, Murtough S, Zaman N, Pennington DJ, Blaydon DC and Kelsell DP (2020). iRHOM2: A Regulator of Palmoplantar Biology, Inflammation, and Viral Susceptibility. Elsevier Journal of Investigative Dermatology vol. 141, (4) 722-726. 10.1016/j.jid.2020.09.010
2018
Arcidiacono P, Webb CM, Brooke MA, Zhou H, Delaney PJ, Ng K-E, Blaydon DC, Tinker A, Kelsell DP and Chikh A (2018). p63 is a key regulator of iRHOM2 signalling in the keratinocyte stress response. Springer Nature Nature Communications vol. 9, (1) 10.1038/s41467-018-03470-y
2017
Maruthappu T, McGinty LA, Blaydon DC, Fell B, Määttä A, Duit R, Hawkins T, Braun KM, Simpson MA, O’Toole EA and Kelsell DP (2017). Recessive Mutation in FAM83G Associated with Palmoplantar Keratoderma and Exuberant Scalp Hair. Elsevier Journal of Investigative Dermatology vol. 138, (4) 984-987. 10.1016/j.jid.2017.10.031
Maruthappu T, Chikh A, Fell B, Delaney PJ, Brooke MA, Levet C, Moncada-Pazos A, Ishida-Yamamoto A, Blaydon D, Waseem A, Leigh IM, Freeman M and KELSELL DP (2017). Rhomboid family member 2 Regulates cytoskeletal stress associated Keratin 16. Nature Publishing Group Nature Communications vol. 8, 14174-14174. 10.1038/ncomms14174
2016
Pigors M, Sarig O, Heinz L, Plagnol V, Fischer F, Mohamad J, Malchin N, Rajpopat S, Kharfi M, Lestringant GG, Sprecher E, Kelsell DP and Blaydon DC (2016). Loss-of-function mutations in SERPINB8 linked to exfoliative ichthyosis with impaired mechanical stability of intercellular adhesions. Elsevier (Cell Press): 6 Month Embargo American Journal of Human Genetics 10.1016/j.ajhg.2016.06.004
Krøigård AB, Hetland LE, Clemmensen O, Blaydon DC, Hertz JM and Bygum A (2016). The first Danish family reported with an AQP5 mutation presenting diffuse non-epidermolytic palmoplantar keratoderma of Bothnian type, hyperhidrosis and frequent Corynebacterium infections: a case report. Bmc Dermatology vol. 16, (1) 10.1186/s12895-016-0044-3
2014
Blaydon DC and Kelsell DP (2014). Defective channels lead to an impaired skin barrier. J Cell Sci vol. 127, (Pt 20) 4343-4350. 10.1242/jcs.154633
2013
Blaydon DC, Lind LK, Plagnol V, Linton KJ, Smith FJD, Wilson NJ, McLean WHI, Munro CS, South AP, Leigh IM, O'Toole EA, Lundström A and Kelsell DP (2013). Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. Am J Hum Genet vol. 93, (2) 330-335. 10.1016/j.ajhg.2013.06.008
Scott CA, Plagnol V, Nitoiu D, Bland PJ, Blaydon DC, Chronnell CM, Poon DS, Bourn D, Gárdos L, Császár A, Tihanyi M, Rustin M, Burrows NP, Bennett C, Harper JI, Conrad B, Verma IC, Taibjee SM, Moss C, O'Toole EA and Kelsell DP (2013). Targeted sequence capture and high-throughput sequencing in the molecular diagnosis of ichthyosis and other skin diseases. J Invest Dermatol vol. 133, (2) 573-576. 10.1038/jid.2012.332
Etheridge SL, Brooke MA, Kelsell DP and Blaydon DC (2013). Rhomboid proteins: A role in keratinocyte proliferation and cancer. Cell and Tissue Research vol. 351, (2) 301-307. 10.1007/s00441-012-1542-1
Scott CA, Plagnol V, Nitoiu D, Bland PJ, Blaydon DC, Chronnell CM, Poon DS, Bourn D, Gárdos L, Császár A, Tihanyi M, Rustin M, Burrows NP, Bennett C, Harper JI, Conrad B, Verma IC, Taibjee SM, Moss C, O'Toole EA and Kelsell DP (2013). Targeted sequence capture and high-throughput sequencing in the molecular diagnosis of ichthyosis and other skin diseases. Journal of Investigative Dermatology vol. 133, (2) 573-576. 10.1038/jid.2012.332
2012
Blaydon DC, Etheridge SL, Risk JM, Hennies H-C, Gay LJ, Carroll R, Plagnol V, McRonald FE, Stevens HP, Spurr NK, Bishop DT, Ellis A, Jankowski J, Field JK, Leigh IM, South AP and Kelsell DP (2012). RHBDF2 mutations are associated with tylosis, a familial esophageal cancer syndrome. Am J Hum Genet vol. 90, (2) 340-346. 10.1016/j.ajhg.2011.12.008
Etheridge SL, Brooke MA, Kelsell DP and Blaydon DC (2012). Rhomboid proteins: a role in keratinocyte proliferation and cancer. Cell and Tissue Research 1-7. 10.1007/s00441-012-1542-1
2011
Blaydon DC, Biancheri P, Di W-L, Plagnol V, Cabral RM, Brooke MA, van Heel DA, Ruschendorf F, Toynbee M, Walne A, O'Toole EA, Martin JE, Lindley K, Vulliamy T, Abrams DJ, MacDonald TT, Harper JI and Kelsell DP (2011). Inflammatory skin and bowel disease linked to ADAM17 deletion. N Engl J Med vol. 365, (16) 1502-1508. 10.1056/NEJMoa1100721
Blaydon DC, Nitoiu D, Eckl K-M, Cabral RM, Bland P, Hausser I, van Heel DA, Rajpopat S, Fischer J, Oji V, Zvulunov A, Traupe H, Hennies HC and Kelsell DP (2011). Mutations in CSTA, encoding Cystatin A, underlie exfoliative ichthyosis and reveal a role for this protease inhibitor in cell-cell adhesion. Am J Hum Genet vol. 89, (4) 564-571. 10.1016/j.ajhg.2011.09.001
2008
Ishii Y, Wajid M, Bazzi H, Fantauzzo KA, Barber AG, Blaydon DC, Nam J-S, Yoon JK, Kelsell DP and Christiano AM (2008). Mutations in R-spondin 4 (RSPO4) underlie inherited anonychia. J Invest Dermatol vol. 128, (4) 867-870. 10.1038/sj.jid.5701078
2007
Blaydon DC, Philpott MP and Kelsell DP (2007). R-spondins in cutaneous biology: Nails and cancer. Cell Cycle vol. 6, (8) 895-897. 10.4161/cc.6.8.4136
Blaydon DC, Philpott MP and Kelsell DP (2007). R-spondins in cutaneous biology: nails and cancer. Cell Cycle vol. 6, (8) 895-897. 10.4161/cc.6.8.4136
Teh MT, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP and Philpott MP (2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation (vol 120, pg 330, 2007). J Cell Sci vol. 120, (5) 917-917. 10.1242/jcs.03329
Teh M-T, Blaydon D, Ghali LR, Briggs V, Edmunds S, Pantazi E, Barnes MR, Leigh IM, Kelsell DP and Philpott MP (2007). Role for WNT16B in human epidermal keratinocyte proliferation and differentiation. J Cell Sci vol. 120, (Pt 2) 330-339. 10.1242/jcs.03329
2006
Blaydon DC, Ishii Y, O'Toole EA, Unsworth HC, Teh M-T, Rüschendorf F, Sinclair C, Hopsu-Havu VK, Tidman N, Moss C, Watson R, de Berker D, Wajid M, Christiano AM and Kelsell DP (2006). The gene encoding R-spondin 4 (RSPO4), a secreted protein implicated in Wnt signaling, is mutated in inherited anonychia. Nat Genet vol. 38, (11) 1245-1247. 10.1038/ng1883
2005
Teh M-T, Blaydon D, Chaplin T, Foot NJ, Skoulakis S, Raghavan M, Harwood CA, Proby CM, Philpott MP, Young BD and Kelsell DP (2005). Genomewide single nucleotide polymorphism microarray mapping in basal cell carcinomas unveils uniparental disomy as a key somatic event. Cancer Res vol. 65, (19) 8597-8603. 10.1158/0008-5472.CAN-05-0842
2003
Blaydon DC, Mueller RF, Hutchin TP, Leroy BP, Bhattacharya SS, Bird AC, Malcolm S and Bitner-Glindzicz M (2003). The contribution of USH1C mutations to syndromic and non-syndromic deafness in the UK. Clin Genet vol. 63, (4) 303-307. 10.1034/j.1399-0004.2003.00058.x
Grants
Dissecting the molecular mechanisms associated with impaired barrier integrity in the oesophageal epithelium
Schalke DC
£41,085 Barts Charity (08-11-2021 - 07-11-2022)
Schalke DC
£41,085 Barts Charity (08-11-2021 - 07-11-2022)
Dissecting palmoplantar skin/keratinocytes as a model of stress – a role for AQP5
Schalke DC and Ramos Del Cano L
£85,000 British Skin Foundation (23-09-2019 - 22-09-2022)
Schalke DC and Ramos Del Cano L
£85,000 British Skin Foundation (23-09-2019 - 22-09-2022)