Prof Claudia Langenberg

Claudia Langenberg

Director and Professor of Medicine and Population Health

Precision Healthcare University Research Institute (PHURI)
Queen Mary University of London
07904 626555

Research

Genomics

Interests

Claudia's research is focused on the genetic basis of metabolic control, and her team studies its effects on health through integration of molecular with clinical data in large-scale patient and population-based studies.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2026

Associations of proteomic age clocks with lifestyle risk factors, incident chronic diseases and mortality in two European cohorts
Nature Aging, 1-15.  
29-06-2026
Data-Driven Decision Support in Obesity Management Commission: enabling more equitable and personalized obesity care
Franks PW, Suliman SGI, Timpson NJ, Langenberg C, le Roux CW
Nature Medicine, Springer Nature vol. 32 (6), 1959-1961.  
12-05-2026
Multi-cohort proteogenomic analyses reveal genetic effects across the proteome and diseasome
Koprulu M, Smith-Byrne K, Ferolito BR, Macdonald-Dunlop E, Luan J, Hedman ÅK, Ogamba CF, Kuliesius J et al.
Cell, Elsevier vol. 189 (11), 3339-3357.e11.  
01-05-2026
Data-driven prioritization of high-risk individuals for weight loss interventions
Demircan K, Carrasco-Zanini J, Williamson A, Beuchel C, Jackson L, Römisch-Margl W, Hansen AL, Finer S et al.
Nature Medicine, Springer Nature vol. 32 (6), 2117-2127.  
30-04-2026
Publisher Correction: Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting
Fejzo M, Wang X, Tan Q, Zöllner J, Pujol-Gualdo N, Laisk T, Finer S, van Heel DA et al.
Nature Genetics, Springer Nature vol. 58 (5), 1186-1186.  
28-04-2026
Glycerol-driven TNAP activation in thermogenesis and mineralization
Hussain MF, Krishnan SS, Carroll BL, Samborska B, Mousa A, Williamson A, Delgado-Martin M, Srinivasu BY et al.
Nature, Springer Nature vol. 654 (8117), 198-208.  
22-04-2026
The contribution of apolipoprotein E genetic variation to dementia risk in British South Asians
Jacobs BM, Chandra A, Foote IF, Durrani F, Waters S, Liu Y, Proitsi P, Maher E et al.
Brain Communications, Oxford University Press (Oup) vol. 8 (3) 
17-04-2026
Precision medicine in low-income settings and small island developing states
Saluja S, Mannan F, Pare G, Anand SS, Hanchard NA, Langenberg C, Anderson SG
Nature Reviews Endocrinology, Springer Nature, 1-11.  
16-04-2026
Multi-ancestry genome-wide association study of severe pregnancy nausea and vomiting
Fejzo M, Wang X, Tan Q, Zöllner J, Pujol-Gualdo N, Laisk T, Finer S, van Heel DA et al.
Nature Genetics, Springer Nature vol. 58 (4), 810-820.  
01-04-2026
Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity
Kim HI, DeBoever C, Walter K, Kalantzis G, Li C, Mozaffari SV, Kundu K, Jacobs BM et al.
Nature Genetics, Springer Nature vol. 58 (4), 821-830.  
27-03-2026
A predictive atlas of disease onset from retinal fundus photographs: a modelling study using data from population-based cohorts
Buergel T, Loock L, Steinfeldt J, Kronenberg N, Hoffmann L, Künzel SE, Upmeier Zu Belzen J, Arnoldt L et al.
The Lancet Digital Health, Elsevier vol. 8 (3) 
01-03-2026
HFpEF and MASLD: converging mechanisms and clinical implications
Capone F, Häseli SP, Liu L, Strocchi S, Langenberg C, Lusis AJ, Pietzner M, Muoio DM et al.
Nature Reviews Cardiology, Springer Nature, 1-25.  
23-02-2026
KidneyGenAfrica multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 Africans
Kamiza AB, Chikowore T, Chen G, Ojewunmi O, Machipisa T, Zhou F, Mayanja R, Toure S et al.
Nature Communications, Springer Nature vol. 17 (1) 
10-02-2026
Interactions between genetic predisposition to obesity, insulin resistance and type 2 diabetes risk, and food or beverage intake for incident type 2 diabetes: European Prospective Investigation into Cancer and Nutrition (EPIC) InterAct case–cohort study
Li SX, Imamura F, Sharp SJ, Schulze MB, Zheng J-S, Amiano P, Ardanaz E, Bergmann MM et al.
American Journal of Clinical Nutrition, Elsevier vol. 123 (3) 
16-01-2026

2025

A genes and health recall study of intrahepatic cholestasis of pregnancy and cholestatic liver disease
Constantinides M, Gafton J, Garcia ACA, Dixon PH, Williamson C, Linton K, Finer S, Gill US et al.
Communications Medicine, Springer Nature vol. 5 (1) 
23-12-2025
Leveraging large-scale biobanks for therapeutic target discovery
Ferolito BR, Dashti H, Giambartolomei C, Peloso GM, Golden DJ, Gravel-Pucillo K, Rasooly D, Horimoto ARVR et al.
Human Genetics and Genomics Advances, Elsevier vol. 7 (1) 
09-12-2025
Associations of visceral adipose tissue with ASCVD across BMI categories
Makhmudova U, Wild B, Steinhagen-Thiessen E, Williamson A, Langenberg C, Eils R, Landmesser U, Sannino A
European Heart Journal, Oxford University Press (Oup) vol. 46 (Supplement_1) 
05-11-2025
Strengthening the reporting of observational studies in epidemiology using Mendelian randomization (STROBE-MR): a Korean translation of explanation and elaboration
Skrivankova VW, Richmond RC, Woolf BAR, Davies NM, Swanson SA, VanderWeele TJ, Timpson NJ, Higgins JPT et al.
The Ewha Medical Journal, The Ewha Medical Journal, Ewha Womans University College of Medicine vol. 48 (4) 
27-10-2025
Obesity due to MC4R deficiency is associated with reduced cholesterol, triglycerides and cardiovascular disease risk
Zorn S, Bounds R, Williamson A, Lawler K, Hanssen R, Keogh J, Henning E, Smith M et al.
Nature Medicine, Springer Nature vol. 31 (12), 4180-4188.  
16-10-2025
Machine learning-guided deconvolution of plasma protein levels
Pietzner M, Beuchel C, Demircan K, Hoffmann Anton J, Zeng W, Römisch-Margl W, Yasmeen S, Uluvar B et al.
Molecular Systems Biology, Springer Nature vol. 21 (12), 1822-1844.  
09-10-2025
A genetic map of human metabolism across the allele frequency spectrum
Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M et al.
Nature Genetics, Springer Nature vol. 57 (10), 2445-2455.  
01-10-2025
Undiagnosed G6PD deficiency in Black and Asian individuals is prevalent and contributes to health inequalities in type 2 diabetes diagnosis and complications
Martin S, Samuel M, Stow D, Ridsdale AM, Chen J, Young KG, Green HD, Hattersley AT et al.
Diabetes Care, American Diabetes Association vol. 48 (11), 1932-1941.  
30-09-2025
XBP1 expression in pancreatic islet cells is associated with poor glycaemic control especially in young non-obese onset diabetes across ancestries
Siddiqui MK, Dupuis T, Anjana RM, Dawed AY, Bigossi M, Srinivasan S, Hodgson S, Adedire ET et al.
Communications Medicine, Springer Nature vol. 5 (1) 
24-09-2025
Plasma Metabolite N-Formylmethionine Is Associated With Higher Blood Pressure in the Multiethnic HELIUS Cohort and Triggers Vascular Dysfunction
Verhaar BJH, Romp N, Mosterd CM, Nguyen TT, Nageswaran V, Rad PR, Winkelmeijer M, Schimmel AWM et al.
Hypertension, Wolters Kluwer vol. 82 (11), 1916-1929.  
17-09-2025
KidneyGenAfrica, a pan-African partnership to deliver research and training excellence in genomics of kidney disease
Fatumo S, Ojewunmi O, Camenzuli R, Kintu C, Kamiza A, Brandenburg J-T, Kalungi A, Kalyesubula R et al.
Nature Genetics, Springer Nature vol. 57 (9), 2079-2082.  
20-08-2025
APOE Genotype and Statin Response: Evidence From the UK Biobank and All of Us Program
Asiimwe IG, Jorgensen AL, Pirmohamed M, Butterworth A, Warwick A, Fernandez‐Sanles A, Henry A, Lai AG et al.
Clinical and Translational Science, Wiley vol. 18 (8) 
01-08-2025
Polygenic prediction of body mass index and obesity through the life course and across ancestries
Smit RAJ, Wade KH, Hui Q, Arias JD, Yin X, Christiansen MR, Yengo L, Preuss MH et al.
Nature Medicine, Springer Nature vol. 31 (9), 3151-3168.  
21-07-2025
Visceral adipose tissue, aortic distensibility and atherosclerotic cardiovascular risk across body mass index categories
Makhmudova U, Wild B, Williamson A, Steinhagen-Thiessen E, Langenberg C, Eils R, Landmesser U, Sannino A
European Journal of Preventive Cardiology, Oxford University Press (Oup) 
18-07-2025
Associations of proteomic age with mortality and incident chronic diseases in the European Prospective Investigation into Cancer and Nutrition (EPIC)
Robinson O, Xiao H, Homann J, Viallon V, Ferrari P, Huerta JM, Zabala AJ, Kaaks R et al.
, Springer Nature, rs.3.rs-7087230.  
15-07-2025
A computational framework for defining and validating reproducible phenotyping algorithms of 313 diseases in the UK Biobank
Torralbo A, Davitte JM, Croteau-Chonka DC, Ytsma C, Tomlinson C, Fitzpatrick NK, Chung S-C, Fatemifar G et al.
Scientific Reports, Springer Nature vol. 15 (1) 
09-07-2025
Sex differences in the genetic regulation of the human plasma proteome
Koprulu M, Wheeler E, Kerrison ND, Denaxas S, Carrasco-Zanini J, Orkin CM, Hemingway H, Wareham NJ et al.
Nature Communications, Springer Nature vol. 16 (1) 
13-05-2025
Inherited predisposition to pneumothorax: estimating the frequency of Birt-Hogg-Dubé syndrome from genomics and population cohorts
Yngvadottir B, Richman L, Andreou A, Woodley J, Luharia A, Lim D, Akhtar S, Anwar M et al.
Thorax, Bmj vol. 80 (8), 553-555.  
10-04-2025
Genome-wide association study meta-analysis provides insights into the etiology of heart failure and its subtypes
Henry A, Mo X, Finan C, Chaffin MD, Speed D, Issa H, Denaxas S, Ware JS et al.
Nature Genetics, Springer Nature vol. 57 (4), 815-828.  
04-03-2025
Understanding the potential contribution of polygenic risk scores to the prediction of gestational and type 2 diabetes in women from British Pakistani and Bangladeshi groups: a cohort study in Genes and Health
Zöllner J, Orazumbekova B, Hodgson S, van Heel DA, Team GAHR, Akhtar S, Anwar M, Asgar O et al.
Ajog Global Reports, Elsevier vol. 5 (2) 
21-02-2025
Author Correction: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats
Steinfeldt J, Wild B, Buergel T, Pietzner M, Upmeier zu Belzen J, Vauvelle A, Hegselmann S, Denaxas S et al.
Nature Communications, Springer Nature vol. 16 (1) 
10-02-2025
Large-scale multi-omics identifies drug targets for heart failure with reduced and preserved ejection fraction
Rasooly D, Giambartolomei C, Peloso GM, Dashti H, Ferolito BR, Golden D, Horimoto ARVR, Pietzner M et al.
Nature Cardiovascular Research, Springer Nature vol. 4 (3), 293-311.  
06-02-2025
Integrative proteogenomic analysis identifies COL6A3-derived endotrophin as a mediator of the effect of obesity on coronary artery disease
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Su C-Y, Chen Y, Liang K, Willett JDS et al.
Nature Genetics, Springer Nature vol. 57 (2), 345-357.  
24-01-2025
Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats
Steinfeldt J, Wild B, Buergel T, Pietzner M, Upmeier zu Belzen J, Vauvelle A, Hegselmann S, Denaxas S et al.
Nature Communications, Springer Nature vol. 16 (1) 
10-01-2025

2024

Long term health outcomes in people with diabetes 12 months after hospitalisation with COVID-19 in the UK: a prospective cohort study
Gharibzadeh S, Routen A, Razieh C, Zaccardi F, Lawson C, Gillies C, Heller S, Davies M et al.
Eclinicalmedicine, Elsevier vol. 79 
27-12-2024
Genetic basis of early onset and progression of type 2 diabetes in South Asians
Hodgson S, Williamson A, Bigossi M, Stow D, Jacobs BM, Samuel M, Gafton J, Zöllner J et al.
Nature Medicine, Springer Nature vol. 31 (1), 323-331.  
26-11-2024
Altered IL-6 signalling and risk of tuberculosis: a multi-ancestry mendelian randomisation study
Hamilton F, Schurz H, Yates TA, Gilchrist JJ, Möller M, Naranbhai V, Ghazal P, Timpson NJ et al.
The Lancet Microbe, Elsevier vol. 6 (1) 
21-11-2024
Incidence of diabetes mellitus following hospitalisation for COVID‐19 in the United Kingdom: A prospective observational study
Tyrer F, Gharibzadeh S, Gillies C, Lawson C, Routen A, Islam N, Razieh C, Zaccardi F et al.
Diabetes Obesity and Metabolism, Wiley vol. 27 (2), 767-776.  
20-11-2024
Genetic architecture of routinely acquired blood tests in a British South Asian cohort
Jacobs BM, Stow D, Hodgson S, Zöllner J, Samuel M, Kanoni S, Bidi S, Walter K et al.
Nature Communications, Springer Nature vol. 15 (1) 
16-10-2024
Disease coverage of human genome-wide association studies and pharmaceutical research and development
Gordillo-Marañón M, Schmidt AF, Warwick A, Tomlinson C, Ytsma C, Engmann J, Torralbo A, Maclean R et al.
Communications Medicine, Springer Nature vol. 4 (1) 
08-10-2024
Mapping biological influences on the human plasma proteome beyond the genome
Carrasco-Zanini J, Wheeler E, Uluvar B, Kerrison N, Koprulu M, Wareham NJ, Pietzner M, Langenberg C
Nature Metabolism, Springer Nature vol. 6 (10), 2010-2023.  
26-09-2024
Damaging mutations in liver X receptor-α are hepatotoxic and implicate cholesterol sensing in liver health
Lockhart SM, Muso M, Zvetkova I, Lam BYH, Ferrari A, Schoenmakers E, Duckett K, Leslie J et al.
Nature Metabolism, Springer Nature vol. 6 (10), 1922-1938.  
25-09-2024
Damaging mutations in LXR[alpha] uncouple lipogenesis from hepatotoxicity and implicate hepatic cholesterol sensing in human liver health
Lockhart S, Muso M, Zvetkova I, Lam B, Ferrari A, Schoenmakkers E, Duckett K, Leslie J et al.
Endocrine Abstracts, Bioscientifica 
16-09-2024
The genetic landscape of neuro-related proteins in human plasma
Repetto L, Chen J, Yang Z, Zhai R, Timmers PRHJ, Feng X, Li T, Yao Y et al.
Nature Human Behaviour, Springer Nature vol. 8 (11), 2222-2234.  
29-08-2024
Testing for a causal role of thyroid hormone measurements within the normal range on human metabolism and diseases: a systematic Mendelian randomization
Alwan H, Luan J, Williamson A, Carrasco-Zanini J, Stewart ID, Wareham NJ, Langenberg C, Pietzner M
Ebiomedicine, Elsevier vol. 107 
26-08-2024
The performance of AlphaMissense to identify genes influencing disease
Chen Y, Butler-Laporte G, Liang KYH, Ilboudo Y, Yasmeen S, Sasako T, Langenberg C, Greenwood CMT et al.
Human Genetics and Genomics Advances, Elsevier vol. 5 (4) 
22-08-2024
Cognitive and psychiatric symptom trajectories 2–3 years after hospital admission for COVID-19: a longitudinal, prospective cohort study in the UK
Taquet M, Skorniewska Z, De Deyn T, Hampshire A, Trender WR, Hellyer PJ, Chalmers JD, Ho L-P et al.
The Lancet Psychiatry, Elsevier vol. 11 (9), 696-708.  
31-07-2024
An LGR6 frameshift variant abrogates receptor expression on select leukocyte subsets and is associated with viral infections
Gomez EA, De Matteis R, Udomjarumanee P, Team GAHR, Akhtar S, Anwar M, Arciero E, Asgar O et al.
Blood, American Society of Hematology vol. 144 (4), 420-434.  
25-07-2024
Blood proteins predict the risk of many diseases years before onset
Nature Medicine, Springer Nature vol. 30 (9), 2419-2420.  
22-07-2024
Proteomic signatures improve risk prediction for common and rare diseases
Carrasco-Zanini J, Pietzner M, Davitte J, Surendran P, Croteau-Chonka DC, Robins C, Torralbo A, Tomlinson C et al.
Nature Medicine, Springer Nature vol. 30 (9), 2489-2498.  
22-07-2024
Complex patterns of multimorbidity associated with severe COVID-19 and long COVID
Pietzner M, Denaxas S, Yasmeen S, Ulmer MA, Nakanishi T, Arnold M, Kastenmüller G, Hemingway H et al.
Communications Medicine, Springer Nature vol. 4 (1) 
08-07-2024
Proteomic prediction of diverse incident diseases: a machine learning-guided biomarker discovery study using data from a prospective cohort study
Carrasco-Zanini J, Pietzner M, Koprulu M, Wheeler E, Kerrison ND, Wareham NJ, Langenberg C
The Lancet Digital Health, Elsevier vol. 6 (7), e470-e479.  
01-07-2024
Reporting guidelines for precision medicine research of clinical relevance: the BePRECISE checklist
Lim SS, Semnani-Azad Z, Morieri ML, Ng AH, Ahmad A, Fitipaldi H, Boyle J, Collin C et al.
Nature Medicine, Springer Nature vol. 30 (7), 1874-1881.  
01-07-2024
SMIM1 absence is associated with reduced energy expenditure and excess weight
Stefanucci L, Moslemi C, Tomé AR, Virtue S, Bidault G, Gleadall NS, Watson LPE, Kwa JE et al.
Med, Elsevier vol. 5 (9), 1083-1095.e6.  
20-06-2024
Identifying proteomic risk factors for overall, aggressive, and early onset prostate cancer using Mendelian Randomisation and tumour spatial transcriptomics
Desai TA, Hedman ÅK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL et al.
Ebiomedicine, Elsevier vol. 105 
14-06-2024
RETRACTED ARTICLE: Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats
Steinfeldt J, Wild B, Buergel T, Pietzner M, Upmeier zu Belzen J, Vauvelle A, Hegselmann S, Denaxas S et al.
Nature Communications, Springer Nature vol. 15 (1) 
20-05-2024
Long COVID and cardiovascular disease: a prospective cohort study
Lawson CA, Moss AJ, Arnold JR, Bagot C, Banerjee A, Berry C, Greenwood J, Hughes AD et al.
Open Heart, Bmj vol. 11 (1) 
01-05-2024
Genome-wide analysis in over 1 million individuals of European ancestry yields improved polygenic risk scores for blood pressure traits
Keaton JM, Kamali Z, Xie T, Vaez A, Williams A, Goleva SB, Ani A, Evangelou E et al.
Nature Genetics, Springer Nature vol. 56 (5), 778-791.  
30-04-2024
Identifying therapeutic targets for cancer among 2074 circulating proteins and risk of nine cancers
Smith-Byrne K, Hedman Å, Dimitriou M, Desai T, Sokolov AV, Schioth HB, Koprulu M, Pietzner M et al.
Nature Communications, Springer Nature vol. 15 (1) 
29-04-2024
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA et al.
Nature Genetics, Springer Nature vol. 56 (5), 1032-1033.  
19-04-2024
Large-scale phenotyping of patients with long COVID post-hospitalization reveals mechanistic subtypes of disease
Liew F, Efstathiou C, Fontanella S, Richardson M, Saunders R, Swieboda D, Sidhu JK, Ascough S et al.
Nature Immunology, Springer Nature vol. 25 (4), 607-621.  
01-04-2024
Long-term impact of COVID-19 hospitalisation among individuals with pre-existing airway diseases in the UK: a multicentre, longitudinal cohort study – PHOSP-COVID
Elneima O, Hurst JR, Echevarria C, Quint JK, Walker S, Siddiqui S, Novotny P, Pfeffer PE et al.
Erj Open Research, European Respiratory Society (Ers) vol. 10 (4), 00982-02023.  
28-03-2024
Abstract 7330: Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using mendelian randomization and tumor spatial transcriptomics
Desai TA, Hedman AK, Dimitriou M, Koprulu M, Figiel S, Yin W, Johansson M, Watts EL et al.
Cancer Research, American Association For Cancer Research (Aacr) vol. 84 (6_Supplement), 7330-7330.  
22-03-2024
Prioritization of Kidney Cell Types Highlights Myofibroblast Cells in Regulating Human Blood Pressure
Ganji-Arjenaki M, Kamali Z, Pressure ICOB, Evangelou E, Warren HR, Gao H, Ntritsos G, Dimou N et al.
Kidney International Reports, Elsevier vol. 9 (6), 1849-1859.  
13-03-2024
Systemic proteome adaptions to 7-day complete caloric restriction in humans
Pietzner M, Uluvar B, Kolnes KJ, Jeppesen PB, Frivold SV, Skattebo Ø, Johansen EI, Skålhegg BS et al.
Nature Metabolism, Springer Nature vol. 6 (4), 764-777.  
01-03-2024
Genetic drivers of heterogeneity in type 2 diabetes pathophysiology
Suzuki K, Hatzikotoulas K, Southam L, Taylor HJ, Yin X, Lorenz KM, Mandla R, Huerta-Chagoya A et al.
Nature, Springer Nature vol. 627 (8003), 347-357.  
19-02-2024
Multi-trait analysis characterizes the genetics of thyroid function and identifies causal associations with clinical implications
Sterenborg RBTM, Steinbrenner I, Li Y, Bujnis MN, Naito T, Marouli E, Galesloot TE, Babajide O et al.
Nature Communications, Springer Nature vol. 15 (1) 
30-01-2024
Accelerated immune ageing is associated with COVID-19 disease severity
Lord JM, Veenith T, Sullivan J, Sharma-Oates A, Richter AG, Greening NJ, McAuley HJC, Evans RA et al.
Immunity & Ageing, Springer Nature vol. 21 (1) 
11-01-2024

2023

Genetic determinants of complement activation in the general population
Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Ghasemi-Semeskandeh D, Coassin S et al.
Cell Reports, Elsevier vol. 43 (1) 
29-12-2023
Cohort Profile: Post-Hospitalisation COVID-19 (PHOSP-COVID) study
Elneima O, McAuley HJC, Leavy OC, Chalmers JD, Horsley A, Ho L-P, Marks M, Poinasamy K et al.
International Journal of Epidemiology, Oxford University Press (Oup) vol. 53 (1) 
18-12-2023
Plasma Metabolites Related to the Consumption of Different Types of Dairy Products and Their Association with New‐Onset Type 2 Diabetes: Analyses in the Fenland and EPIC‐Norfolk Studies, United Kingdom
Trichia E, Koulman A, Stewart ID, Brage S, Griffin SJ, Griffin JL, Khaw K, Langenberg C et al.
Molecular Nutrition & Food Research, Wiley vol. 68 (1) 
06-12-2023
Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses
Collaboration ERFCE-CVDS, Sofianopoulou E, Kaptoge SK, Afzal S, Jiang T, Gill D, Gundersen TE, Bolton TR et al.
The Lancet Diabetes & Endocrinology, Elsevier vol. 12 (1), e2-e11.  
01-12-2023
Author Correction: Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al.
Nature Communications, Springer Nature vol. 14 (1) 
27-11-2023
Identification of circulating proteins associated with general cognitive function among middle-aged and older adults
Tin A, Fohner AE, Yang Q, Brody JA, Davies G, Yao J, Liu D, Caro I et al.
Communications Biology, Springer Nature vol. 6 (1) 
03-11-2023
INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett J, Su C et al.
Canadian Journal of Diabetes, Elsevier vol. 47 (7) 
01-11-2023
Multi-omic prediction of incident type 2 diabetes
Carrasco-Zanini J, Pietzner M, Wheeler E, Kerrison ND, Langenberg C, Wareham NJ
Diabetologia, Springer Nature vol. 67 (1), 102-112.  
27-10-2023
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization
Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al.
Wellcome Open Research, F1000research vol. 8 
20-10-2023
Long COVID research: an update from the PHOSP-COVID Scientific Summit
Brightling CE, Evans RA, Singapuri A, Smith N, Wain LV, Brightling CE, Evans RA, Wain LV et al.
The Lancet Respiratory Medicine, Elsevier vol. 11 (11), e93-e94.  
16-10-2023
ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon
Hartmann S, Yasmeen S, Jacobs BM, Denaxas S, Pirmohamed M, Gamazon ER, Caulfield MJ, Hemingway H et al.
Nature Communications, Springer Nature vol. 14 (1) 
12-10-2023
THU582 Actionable Circulating Proteins Mediate The Effect Of Obesity On Cardiometabolic Diseases: An Integrative Proteogenomics Analysis
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett JDS, Su C-Y et al.
Journal of The Endocrine Society, The Endocrine Society vol. 7 (Supplement_1) 
05-10-2023
Performance of polygenic risk scores in screening, prediction, and risk stratification: secondary analysis of data in the Polygenic Score Catalog
Hingorani AD, Gratton J, Finan C, Schmidt AF, Patel R, Sofat R, Kuan V, Langenberg C et al.
Bmj Medicine, Bmj vol. 2 (1) 
01-10-2023
INTEGRATIVE PROTEOGENOMICS ANALYSIS IDENTIFIES COL6A3-DERIVED ENDOTROPHIN AS AN ACTIONABLE MEDIATOR OF THE EFFECT OF OBESITY ON CORONARY ARTERY DISEASE
Yoshiji S, Lu T, Butler-Laporte G, Carrasco-Zanini-Sanchez J, Chen Y, Liang K, Willett J, Su C et al.
Canadian Journal of Cardiology, Elsevier vol. 39 (10), s209-s210.  
01-10-2023
Author Correction: Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Fethnou E, Qafoud F, Alkhayat E, Afifi N, Tomei S, Liu W, Lorenz S, Syed N et al.
Nature Genetics, Springer Nature vol. 55 (10), 1778-1779.  
25-09-2023
Multiorgan MRI findings after hospitalisation with COVID-19 in the UK (C-MORE): a prospective, multicentre, observational cohort study
Brightling CE, Evans RA, Wain LV, Chalmers JD, Harris VC, Ho LP, Horsley A, Marks M et al.
The Lancet Respiratory Medicine, Elsevier vol. 11 (11), 1003-1019.  
22-09-2023
GWAS of random glucose in 476,326 individuals provide insights into diabetes pathophysiology, complications and treatment stratification
Lagou V, Jiang L, Ulrich A, Zudina L, González KSG, Balkhiyarova Z, Faggian A, Maina JG et al.
Nature Genetics, Springer Nature vol. 55 (9), 1448-1461.  
01-09-2023
176 A genome-wide association screening of complement activation from a general population study
Noce D, Foco L, Orth-Höller D, König E, Barbieri G, Pietzner M, Coassin S, Fuchsberger C et al.
Immunobiology, Elsevier vol. 228 (5) 
01-09-2023
Testing for a causal role of thyroid hormone measurements within the normal range: a systematic mendelian randomization study
Alwan H, Luan J, Williamson A, Steward I, Wareham N, Langenberg C, Pietzner M
Endocrine Abstracts, Bioscientifica 
24-08-2023
Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
Carland C, Png G, Malarstig A, Kho PF, Gustafsson S, Michaelsson K, Lind L, Tsafantakis E et al.
Clinical Proteomics, Springer Nature vol. 20 (1) 
07-08-2023
Lowering of Circulating Sclerostin May Increase Risk of Atherosclerosis and Its Risk Factors: Evidence From a Genome‐Wide Association Meta‐Analysis Followed by Mendelian Randomization
Zheng J, Wheeler E, Pietzner M, Andlauer TFM, Yau MS, Hartley AE, Brumpton BM, Rasheed H et al.
Arthritis & Rheumatology, Wiley vol. 75 (10), 1781-1792.  
03-08-2023
Converging evidence from exome sequencing and common variants implicates target genes for osteoporosis
Zhou S, Sosina OA, Bovijn J, Laurent L, Sharma V, Akbari P, Forgetta V, Jiang L et al.
Nature Genetics, Springer Nature vol. 55 (8), 1277-1287.  
01-08-2023
Circulating metabolites modulated by diet are associated with depression
van der Spek A, Stewart ID, Kühnel B, Pietzner M, Alshehri T, Gauß F, Hysi PG, MahmoudianDehkordi S et al.
Molecular Psychiatry, Springer Nature vol. 28 (9), 3874-3887.  
26-07-2023
Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure
Rasooly D, Peloso GM, Pereira AC, Dashti H, Giambartolomei C, Wheeler E, Aung N, Ferolito BR et al.
Nature Communications, Springer Nature vol. 14 (1) 
10-07-2023
Causal associations between cardiorespiratory fitness and type 2 diabetes
Cai L, Gonzales T, Wheeler E, Kerrison ND, Day FR, Langenberg C, Perry JRB, Brage S et al.
Nature Communications, Springer Nature vol. 14 (1) 
03-07-2023
Biological and functional multimorbidity—from mechanisms to management
Langenberg C, Hingorani AD, Whitty CJM
Nature Medicine, Springer Nature vol. 29 (7), 1649-1657.  
01-07-2023
Elevated plasma complement factor H related 5 protein is associated with venous thromboembolism
Iglesias MJ, Sanchez-Rivera L, Ibrahim-Kosta M, Naudin C, Munsch G, Goumidi L, Farm M, Smith PM et al.
Nature Communications, Springer Nature vol. 14 (1) 
07-06-2023
Genome-wide association study and functional characterization identifies candidate genes for insulin-stimulated glucose uptake
Williamson A, Norris DM, Yin X, Broadaway KA, Moxley AH, Vadlamudi S, Wilson EP, Jackson AU et al.
Nature Genetics, Springer Nature vol. 55 (6), 973-983.  
01-06-2023
Author Correction: The power of genetic diversity in genome-wide association studies of lipids
Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al.
Nature, Springer Nature vol. 618 (7965), e19-e20.  
26-05-2023
Genome-wide association analysis identifies ancestry-specific genetic variation associated with acute response to metformin and glipizide in SUGAR-MGH
Li JH, Brenner LN, Kaur V, Figueroa K, Schroeder P, Huerta-Chagoya A, Udler MS, Leong A et al.
Diabetologia, Springer Nature vol. 66 (7), 1260-1272.  
26-05-2023
Determinants of recovery from post-COVID-19 dyspnoea: analysis of UK prospective cohorts of hospitalised COVID-19 patients and community-based controls
Zheng B, Vivaldi G, Daines L, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A et al.
The Lancet Regional Health - Europe, Elsevier vol. 29 
28-04-2023
Circulating proteins to predict COVID-19 severity
Su C-Y, Zhou S, Gonzalez-Kozlova E, Butler-Laporte G, Brunet-Ratnasingham E, Nakanishi T, Jeon W, Morrison DR et al.
Scientific Reports, Springer Nature vol. 13 (1) 
17-04-2023
Effects of sleep disturbance on dyspnoea and impaired lung function following hospital admission due to COVID-19 in the UK: a prospective multicentre cohort study
Jackson C, Stewart ID, Plekhanova T, Cunningham PS, Hazel AL, Al-Sheklly B, Aul R, Bolton CE et al.
The Lancet Respiratory Medicine, Elsevier vol. 11 (8), 673-684.  
15-04-2023
An atlas of genetic scores to predict multi-omic traits
Xu Y, Ritchie SC, Liang Y, Timmers PRHJ, Pietzner M, Lannelongue L, Lambert SA, Tahir UA et al.
Nature, Springer Nature vol. 616 (7955), 123-131.  
29-03-2023
Author Correction: Proteogenomic links to human metabolic diseases
Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C
Nature Metabolism, Springer Nature vol. 5 (4), 710-710.  
19-03-2023
Genome-wide analysis identifies genetic effects on reproductive success and ongoing natural selection at the FADS locus
Mathieson I, Day FR, Barban N, Tropf FC, Brazel DM, Vaez A, van Zuydam N, Bitarello BD et al.
Nature Human Behaviour, Springer Nature vol. 7 (5), 790-801.  
02-03-2023
Multi-ancestry genome-wide association analyses improve resolution of genes and pathways influencing lung function and chronic obstructive pulmonary disease risk
Fethnou E, Qafoud F, Alkhayat E, Afifi N, Tomei S, Liu W, Lorenz S, Syed N et al.
Nature Genetics, Springer Nature vol. 55 (3), 410-422.  
01-03-2023
Prevalence of physical frailty, including risk factors, up to 1 year after hospitalisation for COVID-19 in the UK: a multicentre, longitudinal cohort study
McAuley HJC, Evans RA, Bolton CE, Brightling CE, Chalmers JD, Docherty AB, Elneima O, Greenhaff PL et al.
Eclinicalmedicine, Elsevier vol. 57 
01-03-2023
Proteogenomic links to human metabolic diseases
Koprulu M, Carrasco-Zanini J, Wheeler E, Lockhart S, Kerrison ND, Wareham NJ, Pietzner M, Langenberg C
Nature Metabolism, Springer Nature vol. 5 (3), 516-528.  
23-02-2023
Genome-wide genotype-serum proteome mapping provides insights into the cross-ancestry differences in cardiometabolic disease susceptibility
Xu F, Yu EY-W, Cai X, Yue L, Jing L-P, Liang X, Fu Y, Miao Z et al.
Nature Communications, Springer Nature vol. 14 (1) 
16-02-2023
Genetic mechanisms of 184 neuro-related proteins in human plasma
Repetto L, Chen J, Yang Z, Zhai R, Timmers PRHJ, Li T, Twait EL, May-Wilson S et al.
, Cold Spring Harbor Laboratory 
14-02-2023
Quantifying the Relationship Between Physical Activity Energy Expenditure and Incident Type 2 Diabetes: A Prospective Cohort Study of Device-Measured Activity in 90,096 Adults
Strain T, Dempsey PC, Wijndaele K, Sharp SJ, Kerrison N, Gonzales TI, Li C, Wheeler E et al.
Diabetes Care, American Diabetes Association vol. 46 (6), 1145-1155.  
24-01-2023
Loci for insulin processing and secretion provide insight into type 2 diabetes risk
Broadaway KA, Yin X, Williamson A, Parsons VA, Wilson EP, Moxley AH, Vadlamudi S, Varshney A et al.
American Journal of Human Genetics, Elsevier vol. 110 (2), 284-299.  
23-01-2023
Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study
Zhao J, Stewart ID, Baird D, Mason D, Wright J, Zheng J, Gaunt TR, Evans DM et al.
Ebiomedicine, Elsevier vol. 88 
23-01-2023
The Impact of Acute Nutritional Interventions on the Plasma Proteome
Vernardis SI, Demichev V, Lemke O, Grüning N-M, Messner C, White M, Pietzner M, Peluso A et al.
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society vol. 108 (8), 2087-2098.  
20-01-2023
Large scale phenotype imputation and in vivo functional validation implicate ADAMTS14 as an adiposity gene
Kentistou KA, Luan J, Wittemans LBL, Hambly C, Klaric L, Kutalik Z, Speakman JR, Wareham NJ et al.
Nature Communications, Springer Nature vol. 14 (1) 
19-01-2023
Genetic Risk Score for Intracranial Aneurysms: Prediction of Subarachnoid Hemorrhage and Role in Clinical Heterogeneity
Bakker MK, Kanning JP, Abraham G, Martinsen AE, Winsvold BS, Zwart J-A, Bourcier R, Sawada T et al.
Stroke, Wolters Kluwer vol. 54 (3), 810-818.  
19-01-2023
Large-scale exome array summary statistics resources for glycemic traits to aid effector gene prioritization.
Willems SM, Ng NHJ, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al.
Wellcome Open Research vol. 8 
01-01-2023
Genomic atlas of the plasma metabolome prioritizes metabolites implicated in human diseases
Chen Y, Lu T, Pettersson-Kymmer U, Stewart ID, Butler-Laporte G, Nakanishi T, Cerani A, Liang KYH et al.
Nature Genetics, Springer Nature vol. 55 (1), 44-53.  
01-01-2023

2022

Implicating genes, pleiotropy, and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al.
Genome Biology, Springer Nature vol. 23 (1) 
27-12-2022
SARS-CoV-2-specific nasal IgA wanes 9 months after hospitalisation with COVID-19 and is not induced by subsequent vaccination
Liew F, Talwar S, Cross A, Willett BJ, Scott S, Logan N, Siggins MK, Swieboda D et al.
Ebiomedicine, Elsevier vol. 87 
19-12-2022
Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the etiology of type 2 diabetes
Gardner EJ, Kentistou KA, Stankovic S, Lockhart S, Wheeler E, Day FR, Kerrison ND, Wareham NJ et al.
Cell Genomics, Elsevier vol. 2 (12) 
01-12-2022
Identifying and visualising multimorbidity and comorbidity patterns in patients in the English National Health Service: a population-based study
Kuan V, Denaxas S, Patalay P, Nitsch D, Mathur R, Gonzalez-Izquierdo A, Sofat R, Partridge L et al.
The Lancet Digital Health, Elsevier vol. 5 (1), e16-e27.  
29-11-2022
Correction: The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals
Butler-Laporte G, Gonzalez-Kozlova E, Su C-Y, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L et al.
Clinical Proteomics, Springer Nature vol. 19 (1) 
15-11-2022
Publisher Correction: Stroke genetics informs drug discovery and risk prediction across ancestries
de Laat KF, van Norden AGW, de Kort PL, Vermeer SE, Brouwers PJAM, Gons RAR, Nederkoorn PJ, den Heijer T et al.
Nature, Springer Nature vol. 612 (7938), e7-e7.  
14-11-2022
Rare and common genetic determinants of metabolic individuality and their effects on human health
Surendran P, Stewart ID, Au Yeung VPW, Pietzner M, Raffler J, Wörheide MA, Li C, Smith RF et al.
Nature Medicine, Springer Nature vol. 28 (11), 2321-2332.  
01-11-2022
Proteomic signatures for identification of impaired glucose tolerance
Carrasco-Zanini J, Pietzner M, Lindbohm JV, Wheeler E, Oerton E, Kerrison N, Simpson M, Westacott M et al.
Nature Medicine, Springer Nature vol. 28 (11), 2293-2300.  
01-11-2022
Broad-capture proteomics and machine learning for early detection of type 2 diabetes risk
Nature Medicine, Springer Nature vol. 28 (11), 2261-2262.  
01-11-2022
Mild-to-Moderate Kidney Dysfunction and Cardiovascular Disease: Observational and Mendelian Randomization Analyses
Gaziano L, Sun L, Arnold M, Bell S, Cho K, Kaptoge SK, Song RJ, Burgess S et al.
Circulation, Wolters Kluwer vol. 146 (20), 1507-1517.  
31-10-2022
A saturated map of common genetic variants associated with human height
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al.
Nature, Springer Nature vol. 610 (7933), 704-712.  
12-10-2022
Stroke genetics informs drug discovery and risk prediction across ancestries
de Laat KF, van Norden AGW, de Kort PL, Vermeer SE, Brouwers PJAM, Gons RAR, Nederkoorn PJ, den Heijer T et al.
Nature, Springer Nature vol. 611 (7934), 115-123.  
30-09-2022
The dynamic changes and sex differences of 147 immune-related proteins during acute COVID-19 in 580 individuals
Butler-Laporte G, Gonzalez-Kozlova E, Su C-Y, Zhou S, Nakanishi T, Brunet-Ratnasingham E, Morrison D, Laurent L et al.
Clinical Proteomics, Springer Nature vol. 19 (1) 
28-09-2022
Metabolomic profiles predict individual multidisease outcomes
Buergel T, Steinfeldt J, Ruyoga G, Pietzner M, Bizzarri D, Vojinovic D, Upmeier zu Belzen J, Loock L et al.
Nature Medicine, Springer Nature vol. 28 (11), 2309-2320.  
22-09-2022
Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma
P K, ID S, RS K, M S, K M, A D, DI S, SH C et al.
, Bioscientifica 
12-09-2022
Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention
Wang Z, Emmerich A, Pillon NJ, Moore T, Hemerich D, Cornelis MC, Mazzaferro E, Broos S et al.
Nature Genetics, Springer Nature vol. 54 (9), 1332-1344.  
01-09-2022
ELF5 is a potential respiratory epithelial cell-specific risk gene for severe COVID-19
Pietzner M, Chua RL, Wheeler E, Jechow K, Willett JDS, Radbruch H, Trump S, Heidecker B et al.
Nature Communications, Springer Nature vol. 13 (1) 
15-08-2022
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al.
American Journal of Human Genetics, Elsevier vol. 109 (8), 1366-1387.  
01-08-2022
The Relationship of Maternal Gestational Mass Spectrometry-Derived Metabolites with Offspring Congenital Heart Disease: Results from Multivariable and Mendelian Randomization Analyses
Taylor K, McBride N, Zhao J, Oddie S, Azad R, Wright J, Andreassen OA, Stewart ID et al.
Journal of Cardiovascular Development and Disease, Mdpi vol. 9 (8) 
27-07-2022
Author Correction: Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma
Kachroo P, Stewart ID, Kelly RS, Stav M, Mendez K, Dahlin A, Soeteman DI, Chu SH et al.
Nature Medicine, Springer Nature vol. 28 (8), 1723-1723.  
20-07-2022
HOTAIR interacts with PRC2 complex regulating the regional preadipocyte transcriptome and human fat distribution
Kuo F-C, Neville MJ, Sabaratnam R, Wesolowska-Andersen A, Phillips D, Wittemans LBL, van Dam AD, Loh NY et al.
Cell Reports, Elsevier vol. 40 (4) 
01-07-2022
Development and validation of a metabolite score for red meat intake: an observational cohort study and randomized controlled dietary intervention
Li C, Imamura F, Wedekind R, Stewart ID, Pietzner M, Wheeler E, Forouhi NG, Langenberg C et al.
American Journal of Clinical Nutrition, Elsevier vol. 116 (2), 511-522.  
27-06-2022
Detection and characterization of male sex chromosome abnormalities in the UK Biobank study
Zhao Y, Gardner EJ, Tuke MA, Zhang H, Pietzner M, Koprulu M, Jia RY, Ruth KS et al.
Genetics in Medicine, Elsevier vol. 24 (9), 1909-1919.  
09-06-2022
Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases
Li Y, Cheng Y, Consolato F, Schiano G, Chong MR, Pietzner M, Nguyen NQH, Scherer N et al.
Jci Insight, American Society For Clinical Investigation vol. 7 (10) 
23-05-2022
Whole-exome sequencing identifies rare genetic variants associated with human plasma metabolites
Bomba L, Walter K, Guo Q, Surendran P, Kundu K, Nongmaithem S, Karim MA, Stewart ID et al.
American Journal of Human Genetics, Elsevier vol. 109 (6), 1038-1054.  
13-05-2022
Mendelian randomisation of eosinophils and other cell types in relation to lung function and disease
Guyatt A, John C, Williams AT, Shrine N, Reeve NF, consortium S, Sayers I, Hall I et al.
Thorax, Bmj vol. 78 (5), 496-503.  
10-05-2022
MO048: Genome-wide studies reveal factors associated with circulating uromodulin and its relations with complex diseases
LI Y, Cheng Y, Consolato F, Schiano G, Chong M, Pietzner M, Quynh Nguyen N, Scherer N et al.
Nephrology Dialysis Transplantation, Oxford University Press (Oup) vol. 37 (Supplement_3) 
03-05-2022
Multi-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Mahajan A, Spracklen CN, Zhang W, Ng MCY, Petty LE, Kitajima H, Yu GZ, Rüeger S et al.
Nature Genetics, Springer Nature vol. 54 (5), 560-572.  
01-05-2022
Clinical characteristics with inflammation profiling of long COVID and association with 1-year recovery following hospitalisation in the UK: a prospective observational study
Evans RA, Leavy OC, Richardson M, Elneima O, McAuley HJC, Shikotra A, Singapuri A, Sereno M et al.
The Lancet Respiratory Medicine, Elsevier vol. 10 (8), 761-775.  
23-04-2022
Physical activity attenuates but does not eliminate coronary heart disease risk amongst adults with risk factors: EPIC-CVD case-cohort study
Fortuin-de Smidt MC, Sewe MO, Lassale C, Weiderpass E, Andersson J, Huerta JM, Ekelund U, Aleksandrova K et al.
European Journal of Preventive Cardiology, Oxford University Press (Oup) vol. 29 (12), 1618-1629.  
11-04-2022
Genetic Landscape of the ACE2 Coronavirus Receptor
Yang Z, Macdonald-Dunlop E, Chen J, Zhai R, Li T, Richmond A, Klarić L, Pirastu N et al.
Circulation, Wolters Kluwer vol. 145 (18), 1398-1411.  
07-04-2022
Multi‐phenotype analyses of hemostatic traits with cardiovascular events reveal novel genetic associations
Temprano‐Sagrera G, Sitlani CM, Bone WP, Martin‐Bornez M, Voight BF, Morrison AC, Damrauer SM, de Vries PS et al.
Journal of Thrombosis and Haemostasis, Elsevier vol. 20 (6), 1331-1349.  
29-03-2022
Metabolomic profiling reveals extensive adrenal suppression due to inhaled corticosteroid therapy in asthma
Kachroo P, Stewart ID, Kelly RS, Stav M, Mendez K, Dahlin A, Soeteman DI, Chu SH et al.
Nature Medicine, Springer Nature vol. 28 (4), 814-822.  
21-03-2022
Genetically Determined Reproductive Aging and Coronary Heart Disease: A Bidirectional 2-sample Mendelian Randomization
Dam V, Onland-Moret NC, Burgess S, Chirlaque M-D, Peters SAE, Schuit E, Tikk K, Weiderpass E et al.
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society vol. 107 (7), e2952-e2961.  
20-03-2022
Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes
Seyres D, Cabassi A, Lambourne JJ, Burden F, Farrow S, McKinney H, Batista J, Kempster C et al.
Clinical Epigenetics, Springer Nature vol. 14 (1) 
12-03-2022
Genetic Associations and Architecture of Asthma-COPD Overlap
John C, Guyatt AL, Shrine N, Packer R, Olafsdottir TA, Liu J, Hayden LP, Chu SH et al.
Chest, Elsevier vol. 161 (5), 1155-1166.  
31-01-2022
Cardiovascular Risk Factors and MRI Markers of Cerebral Small Vessel Disease
Taylor-Bateman V, Gill D, Georgakis MK, Malik R, Munroe P, Traylor M, Evangelou E, Warren HR et al.
Neurology, Wolters Kluwer vol. 98 (4), e343-e351.  
24-01-2022
Associations Between Glycemic Traits and Colorectal Cancer: A Mendelian Randomization Analysis
Murphy N, Song M, Papadimitriou N, Carreras-Torres R, Langenberg C, Martin RM, Tsilidis KK, Barroso I et al.
Journal of The National Cancer Institute, Oxford University Press (Oup) vol. 114 (5), 740-752.  
20-01-2022
Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure
Warren H, Keaton J, Kamali Z, Vaez A, Xie T, Ani A, Evangelou E, Levy D et al.
 
01-01-2022
Evidence for Shared Genetic Aetiology Between Schizophrenia, Cardiometabolic, and Inflammation-Related Traits: Genetic Correlation and Colocalization Analyses
Perry BI, Bowker N, Burgess S, Wareham NJ, Upthegrove R, Jones PB, Langenberg C, Khandaker GM
Schizophrenia Bulletin Open, Oxford University Press (Oup) vol. 3 (1) 
01-01-2022
Understanding Disease Mechanisms: From Genome to Phenome via the Proteome
Koprulu M, Carrasco-Zanini J, Wheeler E, Kerrison N, Wareham N, Pietzner M, Langenberg C
 
01-01-2022
GENOME-WIDE STUDIES REVEAL FACTORS ASSOCIATED WITH CIRCULATING UROMODULIN AND ITS RELATIONS WITH COMPLEX DISEASES
Li Y, Cheng Y, Consolato F, Schiano G, Chong M, Pietzner M, Nguyen NQ, Scherer N et al.
 
01-01-2022

2021

The power of genetic diversity in genome-wide association studies of lipids
Graham SE, Clarke SL, Wu K-HH, Kanoni S, Zajac GJM, Ramdas S, Surakka I, Ntalla I et al.
Nature, Springer Nature vol. 600 (7890), 675-679.  
09-12-2021
Identification of Rare Loss-of-Function Genetic Variation Regulating Body Fat Distribution
Koprulu M, Zhao Y, Wheeler E, Dong L, Rocha N, Li C, Griffin JD, Patel S et al.
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society vol. 107 (4), 1065-1077.  
07-12-2021
Mapping the serum proteome to neurological diseases using whole genome sequencing
Png G, Barysenka A, Repetto L, Navarro P, Shen X, Pietzner M, Wheeler E, Wareham NJ et al.
Nature Communications, Springer Nature vol. 12 (1) 
02-12-2021
Synergistic insights into human health from aptamer- and antibody-based proteomic profiling
Pietzner M, Wheeler E, Carrasco-Zanini J, Kerrison ND, Oerton E, Koprulu M, Luan J, Hingorani AD et al.
Nature Communications, Springer Nature vol. 12 (1) 
24-11-2021
Mapping the proteo-genomic convergence of human diseases
Pietzner M, Wheeler E, Carrasco-Zanini J, Cortes A, Koprulu M, Wörheide MA, Oerton E, Cook J et al.
Science, American Association For The Advancement of Science (Aaas) vol. 374 (6569), eabj1541-eabj1541.  
12-11-2021
MC3R links nutritional state to childhood growth and the timing of puberty
Lam BYH, Williamson A, Finer S, Day FR, Tadross JA, Gonçalves Soares A, Wade K, Sweeney P et al.
Nature, Springer Nature vol. 599 (7885), 436-441.  
03-11-2021
Estimating dose-response relationships for vitamin D with coronary heart disease, stroke, and all-cause mortality: observational and Mendelian randomisation analyses
Collaboration ERFCE-CVDS, Sofianopoulou E, Kaptoge SK, Afzal S, Jiang T, Gill D, Gundersen TE, Bolton TR et al.
The Lancet Diabetes & Endocrinology, Elsevier vol. 9 (12), 837-846.  
28-10-2021
Strengthening the Reporting of Observational Studies in Epidemiology Using Mendelian Randomization
Skrivankova VW, Richmond RC, Woolf BAR, Yarmolinsky J, Davies NM, Swanson SA, VanderWeele TJ, Higgins JPT et al.
Jama: The Journal of The American Medical Association, American Medical Association (Ama) vol. 326 (16), 1614-1621.  
26-10-2021
Strengthening the reporting of observational studies in epidemiology using mendelian randomisation (STROBE-MR): explanation and elaboration
Skrivankova VW, Richmond RC, Woolf BAR, Davies NM, Swanson SA, VanderWeele TJ, Timpson NJ, Higgins JPT et al.
The Bmj, Bmj vol. 375 
26-10-2021
Metabolomic differences in lung function metrics: evidence from two cohorts
Kelly RS, Stewart ID, Bayne H, Kachroo P, Spiro A, Vokonas P, Sparrow D, Weiss ST et al.
Thorax, Bmj vol. 77 (9), 919-928.  
14-10-2021
Physical, cognitive, and mental health impacts of COVID-19 after hospitalisation (PHOSP-COVID): a UK multicentre, prospective cohort study
Evans RA, McAuley HJC, Harrison EM, Shikotra A, Singapuri A, Sereno M, Elneima O, Docherty AB et al.
The Lancet Respiratory Medicine, Elsevier vol. 9 (11), 1275-1287.  
07-10-2021
The blood metabolome of incident kidney cancer: A case–control study nested within the MetKid consortium
Guida F, Tan VY, Corbin LJ, Smith-Byrne K, Alcala K, Langenberg C, Stewart ID, Butterworth AS et al.
Plos Medicine, Public Library of Science (Plos) vol. 18 (9) 
20-09-2021
The genomics of heart failure: design and rationale of the HERMES consortium
Lumbers RT, Shah S, Lin H, Czuba T, Henry A, Swerdlow DI, Mälarstig A, Andersson C et al.
Esc Heart Failure, Oxford University Press (Oup) vol. 8 (6), 5531-5541.  
03-09-2021
Identifying adults at high-risk for change in weight and BMI in England: a longitudinal, large-scale, population-based cohort study using electronic health records
Katsoulis M, Lai AG, Diaz-Ordaz K, Gomes M, Pasea L, Banerjee A, Denaxas S, Tsilidis K et al.
The Lancet Diabetes & Endocrinology, Elsevier vol. 9 (10), 681-694.  
02-09-2021
586Effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation analysis
Zhao J, Freathy R, Evans D, Warrington N, Langenberg C, Stewart I, Lotta L, Pietzner M et al.
International Journal of Epidemiology, Oxford University Press (Oup) vol. 50 (Supplement_1) 
01-09-2021
Utility of Genetically Predicted Lp(a) (Lipoprotein [a]) and ApoB Levels for Cardiovascular Risk Assessment
Wu H, Luan J, Forgetta V, Engert JC, Thanassoulis G, Mooser V, Wareham NJ, Langenberg C et al.
Circulation Genomic and Precision Medicine, Wolters Kluwer vol. 14 (5) 
31-08-2021
Estimating the Population Benefits of Blood Pressure Lowering: A Wide‐Angled Mendelian Randomization Study in UK Biobank
Higgins H, Mason AM, Larsson SC, Gill D, Langenberg C, Burgess S
Journal of The American Heart Association, Wolters Kluwer vol. 10 (17) 
28-08-2021
Mitochondrial DNA variants modulate N-formylmethionine, proteostasis and risk of late-onset human diseases
Cai N, Gomez-Duran A, Yonova-Doing E, Kundu K, Burgess AI, Golder ZJ, Calabrese C, Bonder MJ et al.
Nature Medicine, Springer Nature vol. 27 (9), 1564-1575.  
23-08-2021
Genetically Predicted Glucose-Dependent Insulinotropic Polypeptide (GIP) Levels and Cardiovascular Disease Risk Are Driven by Distinct Causal Variants in the GIPR Region
Bowker N, Hansford R, Burgess S, Foley CN, Auyeung VPW, Erzurumluoglu AM, Stewart ID, Wheeler E et al.
Diabetes, American Diabetes Association vol. 70 (11), 2706-2719.  
23-08-2021
Genetic insights into biological mechanisms governing human ovarian ageing
Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, Knoblochova L et al.
Nature, Springer Nature vol. 596 (7872), 393-397.  
04-08-2021
Weight Change and the Onset of Cardiovascular Diseases: Emulating Trials Using Electronic Health Records
Katsoulis M, Stavola BD, Diaz-Ordaz K, Gomes M, Lai A, Lagiou P, Wannamethee G, Tsilidis K et al.
Epidemiology, Wolters Kluwer vol. 32 (5), 744-755.  
28-07-2021
GIGYF1 loss of function is associated with clonal mosaicism and adverse metabolic health
Zhao Y, Stankovic S, Koprulu M, Wheeler E, Day FR, Lango Allen H, Kerrison ND, Pietzner M et al.
Nature Communications, Springer Nature vol. 12 (1) 
07-07-2021
Identification of 371 genetic variants for age at first sex and birth linked to externalising behaviour
Heijmans BT, ‘t Hoen PAC, van Meurs J, Isaacs A, Jansen R, Franke L, Boomsma DI, Pool R et al.
Nature Human Behaviour, Springer Nature vol. 5 (12), 1717-1730.  
01-07-2021
The trans-ancestral genomic architecture of glycemic traits
Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems SM, Wu Y et al.
Nature Genetics, Springer Nature vol. 53 (6), 840-860.  
31-05-2021
Prepubertal Dietary and Plasma Phospholipid Fatty Acids Related to Puberty Timing: Longitudinal Cohort and Mendelian Randomization Analyses
Cheng TS, Day FR, Perry JRB, Luan J, Langenberg C, Forouhi NG, Wareham NJ, Ong KK
Nutrients, Mdpi vol. 13 (6) 
30-05-2021
Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
Gaziano L, Giambartolomei C, Pereira AC, Gaulton A, Posner DC, Swanson SA, Ho Y-L, Iyengar SK et al.
Nature Medicine, Springer Nature vol. 27 (4), 668-676.  
01-04-2021
Reply to Unreliability of genotyping arrays for detecting very rare variants in human genetic studies: Example from a recent study of MC4R
Lotta L, Langenberg C, Wareham NJ, Farooqi IS
Cell, Elsevier vol. 184 (7), 1652-1653.  
01-04-2021
Longitudinal Trends in Childhood Insulin Levels and Body Mass Index and Associations With Risks of Psychosis and Depression in Young Adults
Perry BI, Stochl J, Upthegrove R, Zammit S, Wareham N, Langenberg C, Winpenny E, Dunger D et al.
Jama Psychiatry, American Medical Association (Ama) vol. 78 (4), 416-425.  
01-04-2021
Publisher Correction: Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al.
Nature Genetics, Springer Nature vol. 53 (5), 762-762.  
16-03-2021
The potential shared role of inflammation in insulin resistance and schizophrenia: A bidirectional two-sample mendelian randomization study
Perry BI, Burgess S, Jones HJ, Zammit S, Upthegrove R, Mason AM, Day FR, Langenberg C et al.
Plos Medicine, Public Library of Science (Plos) vol. 18 (3) 
12-03-2021
Genetic disruption of serine biosynthesis is a key driver of macular telangiectasia type 2 aetiology and progression
Bonelli R, Ansell BRE, Lotta L, Scerri T, Clemons TE, Leung I, Peto T, Bird AC et al.
Genome Medicine, Springer Nature vol. 13 (1) 
09-03-2021
Plasma metabolites to profile pathways in noncommunicable disease multimorbidity
Pietzner M, Stewart ID, Raffler J, Khaw K-T, Michelotti GA, Kastenmüller G, Wareham NJ, Langenberg C
Nature Medicine, Springer Nature vol. 27 (3), 471-479.  
01-03-2021
A Neanderthal OAS1 isoform protects individuals of European ancestry against COVID-19 susceptibility and severity
Zhou S, Butler-Laporte G, Nakanishi T, Morrison DR, Afilalo J, Afilalo M, Laurent L, Pietzner M et al.
Nature Medicine, Springer Nature vol. 27 (4), 659-667.  
25-02-2021
Publisher Correction: Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al.
Nature Communications, Springer Nature vol. 12 (1) 
08-02-2021
Author Correction: Genetic architecture of host proteins involved in SARS-CoV-2 infection
Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND, Oerton E, Auyeung VPW, Luan J et al.
Nature Communications, Springer Nature vol. 12 (1) 
02-02-2021
Correction: Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M et al.
International Journal of Obesity, Springer Nature vol. 45 (3), 711-711.  
01-02-2021
Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
Jones G, Trajanoska K, Santanasto AJ, Stringa N, Kuo C-L, Atkins JL, Lewis JR, Duong T et al.
Nature Communications, Springer Nature vol. 12 (1) 
28-01-2021
Diabetes Mellitus, Glycemic Traits, and Cerebrovascular Disease: A Mendelian Randomization Study
Georgakis MK, Harshfield EL, Malik R, Franceschini N, Langenberg C, Wareham NJ, Markus HS, Dichgans M
Neurology, Wolters Kluwer vol. 96 (13) 
25-01-2021
Appetite disinhibition rather than hunger explains genetic effects on adult BMI trajectory
Brunner EJ, Maruyama K, Shipley M, Cable N, Iso H, Hiyoshi A, Stallone D, Kumari M et al.
International Journal of Obesity, Springer Nature vol. 45 (4), 758-765.  
14-01-2021
Sex-dimorphic genetic effects and novel loci for fasting glucose and insulin variability
Lagou V, Mägi R, Hottenga J-J, Grallert H, Perry JRB, Bouatia-Naji N, Marullo L, Rybin D et al.
Nature Communications, Springer Nature vol. 12 (1) 
05-01-2021
Effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation analysis
Zhao J, Freathy R, Evans D, Warrington N, Langenberg C, Stewart I, Lotta L, Pietzner M et al.
 
01-01-2021
A cross-platform approach identifies genetic regulators of human metabolism and health
Lotta LA, Pietzner M, Stewart ID, Wittemans LBL, Li C, Bonelli R, Raffler J, Biggs EK et al.
Nature Genetics, Springer Nature vol. 53 (1), 54-64.  
01-01-2021

2020

Genetic architecture of host proteins involved in SARS-CoV-2 infection
Pietzner M, Wheeler E, Carrasco-Zanini J, Raffler J, Kerrison ND, Oerton E, Auyeung VPW, Luan J et al.
Nature Communications, Springer Nature vol. 11 (1) 
16-12-2020
Discovery of rare variants associated with blood pressure regulation through meta-analysis of 1.3 million individuals
Surendran P, Feofanova EV, Lahrouchi N, Ntalla I, Karthikeyan S, Cook J, Chen L, Mifsud B et al.
Nature Genetics, Springer Nature vol. 52 (12), 1314-1332.  
23-11-2020
Plasma Vitamin C and Type 2 Diabetes: Genome-Wide Association Study and Mendelian Randomization Analysis in European Populations
Zheng J-S, Luan J, Sofianopoulou E, Imamura F, Stewart ID, Day FR, Pietzner M, Wheeler E et al.
Diabetes Care, American Diabetes Association vol. 44 (1), 98-106.  
17-11-2020
Genome-wide association analysis of type 2 diabetes in the EPIC-InterAct study
Cai L, Wheeler E, Kerrison ND, Luan J, Deloukas P, Franks PW, Amiano P, Ardanaz E et al.
Scientific Data, Springer Nature vol. 7 (1) 
13-11-2020
Meta-analysis investigating the role of interleukin-6 mediated inflammation in type 2 diabetes
Bowker N, Shah RL, Sharp SJ, Luan J, Stewart ID, Wheeler E, Ferreira MAR, Baras A et al.
Ebiomedicine, Elsevier vol. 61 
21-10-2020
The association between circulating 25-hydroxyvitamin D metabolites and type 2 diabetes in European populations: A meta-analysis and Mendelian randomisation analysis
Zheng J-S, Luan J, Sofianopoulou E, Sharp SJ, Day FR, Imamura F, Gundersen TE, Lotta LA et al.
Plos Medicine, Public Library of Science (Plos) vol. 17 (10) 
16-10-2020
Integrating Genetics and the Plasma Proteome to Predict the Risk of Type 2 Diabetes
Zanini JC, Pietzner M, Langenberg C
Current Diabetes Reports, Springer Nature vol. 20 (11) 
08-10-2020
Large-scale genomics and proteomics to identify novel circulating biomarkers for bone density
Zhou S, Morris JA, Oerton E, Forgetta V, Langenberg C, Richards JB
Bone Reports, Elsevier vol. 13 
01-10-2020
Genetic Studies of Leptin Concentrations Implicate Leptin in the Regulation of Early Adiposity
Yaghootkar H, Zhang Y, Spracklen CN, Karaderi T, Huang LO, Bradfield J, Schurmann C, Fine RS et al.
Diabetes, American Diabetes Association vol. 69 (12) 
11-09-2020
Corrigendum to “Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort” [Molecular Metabolism 34 (2020) 85–96]
Kulyté A, Lundbäck V, Lindgren CM, Luan J, Lotta LA, Langenberg C, Arner P, Strawbridge RJ et al.
Molecular Metabolism, Elsevier vol. 41 
08-09-2020
A genome-wide association study of asthma-COPD overlap syndrome (ACOS)
John C, Guyatt AL, Shrine N, Olafsdottir T, Liu J, Hayden L, Chu SH, Koskela J et al.
Genes and environment. 
07-09-2020
rs641738C>T near MBOAT7 is associated with liver fat, ALT and fibrosis in NAFLD: A meta-analysis
Teo K, Abeysekera KWM, Adams L, Aigner E, Anstee QM, Banales JM, Banerjee R, Basu P et al.
Journal of Hepatology, Elsevier vol. 74 (1), 20-30.  
31-08-2020
Insights into genetic variants associated with NASH-fibrosis from metabolite profiling
Mann JP, Pietzner M, Wittemans LB, De Lucia Rolfe E, Kerrison ND, Imamura F, Forouhi NG, Fauman E et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 29 (20), 3451-3463.  
28-07-2020
Chronic obstructive pulmonary disease and related phenotypes: polygenic risk scores in population-based and case-control cohorts
Moll M, Sakornsakolpat P, Shrine N, Hobbs BD, DeMeo DL, John C, Guyatt AL, McGeachie MJ et al.
The Lancet Respiratory Medicine, Elsevier vol. 8 (7), 696-708.  
01-07-2020
Ultra-High-Throughput Clinical Proteomics Reveals Classifiers of COVID-19 Infection
Messner CB, Demichev V, Wendisch D, Michalick L, White M, Freiwald A, Textoris-Taube K, Vernardis SI et al.
Cell Systems, Elsevier vol. 11 (1), 11-24.e4.  
02-06-2020
Exome Sequencing Identifies Genes and Gene Sets Contributing to Severe Childhood Obesity, Linking PHIP Variants to Repressed POMC Transcription
Marenne G, Hendricks AE, Perdikari A, Bounds R, Payne F, Keogh JM, Lelliott CJ, Henning E et al.
Cell Metabolism, Elsevier vol. 31 (6), 1107-1119.e12.  
01-06-2020
Variants associated with HHIP expression have sex-differential effects on lung function
Fawcett KA, Obeidat M, Melbourne C, Shrine N, Guyatt AL, John C, Luan J, Richmond A et al.
Wellcome Open Research, F1000research vol. 5 
01-06-2020
M88. EVIDENCE FOR INFLAMMATION AS A PUTATIVE SHARED MECHANISM FOR INSULIN RESISTANCE AND SCHIZOPHRENIA
Perry B, Burgess S, Jones H, Zammit S, Upthegrove R, Mason A, Day F, Stewart I et al.
Schizophrenia Bulletin, Oxford University Press (Oup) vol. 46 (Supplement_1), s168-s168.  
18-05-2020
Genomic analysis of diet composition finds novel loci and associations with health and lifestyle
Meddens SFW, de Vlaming R, Bowers P, Burik CAP, Linnér RK, Lee C, Okbay A, Turley P et al.
Molecular Psychiatry, Springer Nature vol. 26 (6), 2056-2069.  
11-05-2020
SARS-CoV-2 (COVID-19): What Do We Know About Children? A Systematic Review
Mehta NS, Mytton OT, Mullins EWS, Fowler TA, Falconer CL, Murphy OB, Langenberg C, Jayatunga WJP et al.
Clinical Infectious Diseases, Oxford University Press (Oup) vol. 71 (9), 2469-2479.  
11-05-2020
Estimating excess 1-year mortality associated with the COVID-19 pandemic according to underlying conditions and age: a population-based cohort study
Banerjee A, Pasea L, Harris S, Gonzalez-Izquierdo A, Torralbo A, Shallcross L, Noursadeghi M, Pillay D et al.
The Lancet, Elsevier vol. 395 (10238), 1715-1725.  
01-05-2020
PLASMA PROTEIN SCANNING AS A NEW TOOL IN PREVENTIVE CARDIOLOGY
Ostroff R, Langenberg C, Wareham N, Ganz P, Kivimaki M, Bouchard C, Jonasson C, Alexander L et al.
Journal of The American College of Cardiology, Elsevier vol. 75 (11) 
01-03-2020
Genome-wide Association Analysis in Humans Links Nucleotide Metabolism to Leukocyte Telomere Length
Li C, Stoma S, Lotta LA, Warner S, Albrecht E, Allione A, Arp PP, Broer L et al.
American Journal of Human Genetics, Elsevier vol. 106 (3), 389-404.  
27-02-2020
Genome-wide Association Study for Vitamin D Levels Reveals 69 Independent Loci
Manousaki D, Mitchell R, Dudding T, Haworth S, Harroud A, Forgetta V, Shah RL, Luan J et al.
American Journal of Human Genetics, Elsevier vol. 106 (3), 327-337.  
13-02-2020
Using human genetics to understand the disease impacts of testosterone in men and women
Ruth KS, Day FR, Tyrrell J, Thompson DJ, Wood AR, Mahajan A, Beaumont RN, Wittemans L et al.
Nature Medicine, Springer Nature vol. 26 (2), 252-258.  
01-02-2020
Genome-wide association study of adipocyte lipolysis in the GENetics of adipocyte lipolysis (GENiAL) cohort
Kulyté A, Lundbäck V, Lindgren CM, Luan J, Lotta LA, Langenberg C, Arner P, Strawbridge RJ et al.
Molecular Metabolism, Elsevier vol. 34, 85-96.  
25-01-2020
High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease
Zuber V, Gill D, Ala-Korpela M, Langenberg C, Butterworth A, Bottolo L, Burgess S
International Journal of Epidemiology, Oxford University Press (Oup) vol. 50 (3), 893-901.  
11-01-2020
Genome-wide association and Mendelian randomisation analysis provide insights into the pathogenesis of heart failure
Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman ÅK, Wilk JB et al.
Nature Communications, Springer Nature vol. 11 (1) 
09-01-2020
SARS-CoV-2 (COVID-19): What Do We Know About Children? A Systematic Review
Mehta N, Mytton O, Mullins E, Fowler T, Falconer C, Murphy O, Langenberg C, Jayatunga W et al.
In Ssrn Electronic Journal 
01-01-2020
Identifying circulating biomarkers for osteoporosis
Zhou S, Oerton E, Morris J, Wheeler E, Forgetta V, Langenberg C, Richards B
 
01-01-2020
Genome-wide association study of asthma-COPD overlap syndrome identifies new signals of association
John C, Guyatt AL, Shrine N, Olafsdottir T, Liu J, Hayden L, Chu SH, Koskela J et al.
 
01-01-2020
DIABETES MELLITUS, GLYCEMIC TRAITS, AND CEREBROVASCULAR DISEASE: A MENDELIAN RANDOMIZATION STUDY
Georgakis M, Harshfield E, Malik R, Franceschini N, Langenberg C, Wareham N, Markus H, Dichgans M
 
01-01-2020
Hedgehog signalling as a determinant of human fat expansion and distribution
van Dam AD, Toledo EM, Loh NY, Neville MJ, Pinnick KE, Todorcevic M, Dumbill R, Wittemans LBL et al.
 
01-01-2020
EVIDENCE FOR INFLAMMATION AS A PUTATIVE SHARED MECHANISM FOR INSULIN RESISTANCE AND SCHIZOPHRENIA
Perry B, Burgess S, Jones H, Zammit S, Upthegrove R, Mason A, Day F, Stewart I et al.
 
01-01-2020
Genomic Architecture of 184 Plasma Proteins in 18,884 Individuals: the SCALLOP Consortium
Macdonald-Dunlop E, Joshi P, Peters J, Folkersen L, Ingelsson E, Timmers P, Michaelsson K, Gustafsson S et al.
 
01-01-2020

2019

Plasma protein patterns as comprehensive indicators of health
Williams SA, Kivimaki M, Langenberg C, Hingorani AD, Casas JP, Bouchard C, Jonasson C, Sarzynski MA et al.
Nature Medicine, Springer Nature vol. 25 (12), 1851-1857.  
01-12-2019
Functional Screening of Candidate Causal Genes for Insulin Resistance in Human Preadipocytes and Adipocytes
Chen Z, Yu H, Shi X, Warren CR, Lotta LA, Friesen M, Meissner TB, Langenberg C et al.
Circulation Research, Wolters Kluwer vol. 126 (3), 330-346.  
19-11-2019
Autoimmunity plays a role in the onset of diabetes after 40 years of age
Rolandsson O, Hampe CS, Sharp SJ, Ardanaz E, Boeing H, Fagherazzi G, Mancini FR, Nilsson PM et al.
Diabetologia, Springer Nature vol. 63 (2), 266-277.  
11-11-2019
Integrated Analyses of Microbiome and Longitudinal Metabolome Data Reveal Microbial-Host Interactions on Sulfur Metabolism in Parkinson’s Disease
Hertel J, Harms AC, Heinken A, Baldini F, Thinnes CC, Glaab E, Vasco DA, Pietzner M et al.
Cell Reports, Elsevier vol. 29 (7), 1767-1777.e8.  
01-11-2019
Associations of autozygosity with a broad range of human phenotypes
Clark DW, Okada Y, Moore KHS, Mason D, Pirastu N, Gandin I, Mattsson H, Barnes CLK et al.
Nature Communications, Springer Nature vol. 10 (1) 
31-10-2019
Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
Schmidt AF, Holmes MV, Preiss D, Swerdlow DI, Denaxas S, Fatemifar G, Faraway R, Finan C et al.
Bmc Cardiovascular Disorders, Springer Nature vol. 19 (1) 
29-10-2019
Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis
The Bmj, Bmj vol. 367 
09-10-2019
Epigenome-Wide Association Study of Incident Type 2 Diabetes in a British Population: EPIC-Norfolk Study
Cardona A, Day FR, Perry JRB, Loh M, Chu AY, Lehne B, Paul DS, Lotta LA et al.
Diabetes, American Diabetes Association vol. 68 (12), 2315-2326.  
10-09-2019
Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology
Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, Preuss MH, Lu Y et al.
American Journal of Human Genetics, Elsevier vol. 105 (3), 670-671.  
01-09-2019
Estimated Substitution of Tea or Coffee for Sugar-Sweetened Beverages Was Associated with Lower Type 2 Diabetes Incidence in Case–Cohort Analysis across 8 European Countries in the EPIC-InterAct Study
Imamura F, Schulze MB, Sharp SJ, Guevara M, Romaguera D, Bendinelli B, Salamanca-Fernández E, Ardanaz E et al.
Journal of Nutrition, Elsevier vol. 149 (11), 1985-1993.  
08-08-2019
Quality of dietary fat and genetic risk of type 2 diabetes: individual participant data meta-analysis
Merino J, Guasch-Ferré M, Ellervik C, Dashti HS, Sharp SJ, Wu P, Overvad K, Sarnowski C et al.
The Bmj, Bmj vol. 366 
25-07-2019
Metabolomics Analytics Workflow for Epidemiological Research: Perspectives from the Consortium of Metabolomics Studies (COMETS) †
Playdon MC, Joshi AD, Tabung FK, Cheng S, Henglin M, Kim A, Lin T, van Roekel EH et al.
Metabolites, Mdpi vol. 9 (7) 
17-07-2019
Interleukin-18 as a drug repositioning opportunity for inflammatory bowel disease: A Mendelian randomization study
Mokry LE, Zhou S, Guo C, Scott RA, Devey L, Langenberg C, Wareham N, Waterworth D et al.
Scientific Reports, Springer Nature vol. 9 (1) 
28-06-2019
Exome-Derived Adiponectin-Associated Variants Implicate Obesity and Lipid Biology
Spracklen CN, Karaderi T, Yaghootkar H, Schurmann C, Fine RS, Kutalik Z, Preuss MH, Lu Y et al.
American Journal of Human Genetics, Elsevier vol. 105 (1), 15-28.  
06-06-2019
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al.
Nature Genetics, Springer Nature vol. 51 (7), 1191-1192.  
03-06-2019
Publisher Correction: Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese A-K et al.
Nature Genetics, Springer Nature vol. 51 (7), 1192-1193.  
03-06-2019
Regional fat depot masses are influenced by protein-coding gene variants
Neville MJ, Wittemans LBL, Pinnick KE, Todorčević M, Kaksonen R, Pietiläinen KH, Luan J, Scott RA et al.
Plos One, Public Library of Science (Plos) vol. 14 (5) 
30-05-2019
MicroRNA-196a links human body fat distribution to adipose tissue extracellular matrix composition
Hilton C, Neville MJ, Wittemans LBL, Todorcevic M, Pinnick KE, Pulit SL, Luan J, Kulyté A et al.
Ebiomedicine, Elsevier vol. 44, 467-475.  
28-05-2019
Author Correction: New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA et al.
Nature Genetics, Springer Nature vol. 51 (6), 1067-1067.  
20-05-2019
Liver Function and Risk of Type 2 Diabetes: Bidirectional Mendelian Randomization Study
De Silva NMG, Borges MC, Hingorani AD, Engmann J, Shah T, Zhang X, Luan J, Langenberg C et al.
Diabetes, American Diabetes Association vol. 68 (8), 1681-1691.  
14-05-2019
Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
Warrington NM, Beaumont RN, Horikoshi M, Day FR, Helgeland Ø, Laurin C, Bacelis J, Peng S et al.
Nature Genetics, Springer Nature vol. 51 (5), 804-814.  
01-05-2019
Generalizability of a Diabetes-Associated Country-Specific Exploratory Dietary Pattern Is Feasible Across European Populations
Jannasch F, Kröger J, Agnoli C, Barricarte A, Boeing H, Cayssials V, Colorado-Yohar S, Dahm CC et al.
Journal of Nutrition, Elsevier vol. 149 (6), 1047-1055.  
24-04-2019
Consumption of Meat, Fish, Dairy Products, Eggs and Risk of Ischemic Heart Disease: A Prospective Study of 7198 Incident Cases Among 409,885 Participants in the Pan-European EPIC Cohort
Key TJ, Appleby PN, Bradbury KE, Sweeting M, Wood A, Johansson I, Kühn T, Steur M et al.
Circulation, Wolters Kluwer vol. 139 (25), 2835-2845.  
22-04-2019
Steroid receptor coactivator-1 modulates the function of Pomc neurons and energy homeostasis
Yang Y, van der Klaauw AA, Zhu L, Cacciottolo TM, He Y, Stadler LKJ, Wang C, Xu P et al.
Nature Communications, Springer Nature vol. 10 (1) 
12-04-2019
A multi-ancestry genome-wide study incorporating gene–smoking interactions identifies multiple new loci for pulse pressure and mean arterial pressure
Sung YJ, de las Fuentes L, Winkler TW, Chasman DI, Bentley AR, Kraja AT, Ntalla I, Warren HR et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 28 (15), 2615-2633.  
10-04-2019
Human Gain-of-Function MC4R Variants Show Signaling Bias and Protect against Obesity
Lotta LA, Mokrosiński J, de Oliveira EM, Li C, Sharp SJ, Luan J, Brouwers B, Ayinampudi V et al.
Cell, Elsevier vol. 177 (3), 597-607.e9.  
01-04-2019
Multi-ancestry genome-wide gene–smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids
Bentley AR, Sung YJ, Brown MR, Winkler TW, Kraja AT, Ntalla I, Schwander K, Chasman DI et al.
Nature Genetics, Springer Nature vol. 51 (4), 636-648.  
29-03-2019
Assessing the causal association of glycine with risk of cardio-metabolic diseases
Wittemans LBL, Lotta LA, Oliver-Williams C, Stewart ID, Surendran P, Karthikeyan S, Day FR, Koulman A et al.
Nature Communications, Springer Nature vol. 10 (1) 
05-03-2019
Genetic landscape of chronic obstructive pulmonary disease identifies heterogeneous cell-type and phenotype associations
Sakornsakolpat P, Prokopenko D, Lamontagne M, Reeve NF, Guyatt AL, Jackson VE, Shrine N, Qiao D et al.
Nature Genetics, Springer Nature vol. 51 (3), 494-505.  
25-02-2019
New genetic signals for lung function highlight pathways and chronic obstructive pulmonary disease associations across multiple ancestries
Shrine N, Guyatt AL, Erzurumluoglu AM, Jackson VE, Hobbs BD, Melbourne CA, Batini C, Fawcett KA et al.
Nature Genetics, Springer Nature vol. 51 (3), 481-493.  
25-02-2019
Association of menopausal characteristics and risk of coronary heart disease: a pan-European case–cohort analysis
Dam V, van der Schouw YT, Onland-Moret NC, Groenwold RHH, Peters SAE, Burgess S, Wood AM, Chirlaque M-D et al.
International Journal of Epidemiology, Oxford University Press (Oup) vol. 48 (4), 1275-1285.  
22-02-2019
The Consortium of Metabolomics Studies (COMETS): Metabolomics in 47 Prospective Cohort Studies
Yu B, Zanetti KA, Temprosa M, Albanes D, Appel N, Barrera CB, Ben-Shlomo Y, Boerwinkle E et al.
American Journal of Epidemiology, Oxford University Press (Oup) vol. 188 (6), 991-1012.  
19-02-2019
Protein-coding variants implicate novel genes related to lipid homeostasis contributing to body-fat distribution
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al.
Nature Genetics, Springer Nature vol. 51 (3), 452-469.  
18-02-2019
Dairy Product Intake and Risk of Type 2 Diabetes in EPIC-InterAct: A Mendelian Randomization Study
Vissers LET, Sluijs I, van der Schouw YT, Forouhi NG, Imamura F, Burgess S, Barricarte A, Boeing H et al.
Diabetes Care, American Diabetes Association vol. 42 (4) 
06-02-2019
Multiancestry Genome-Wide Association Study of Lipid Levels Incorporating Gene-Alcohol Interactions
de Vries PS, Brown MR, Bentley AR, Sung YJ, Winkler TW, Ntalla I, Schwander K, Kraja AT et al.
American Journal of Epidemiology, Oxford University Press (Oup) vol. 188 (6), 1033-1054.  
29-01-2019
Serum magnesium and calcium levels in relation to ischemic stroke: Mendelian randomization study
Larsson SC, Traylor M, Burgess S, Boncoraglio GB, Jern C, Michaëlsson K, Markus HS, Consortium FTMPOTISG et al.
Neurology, Wolters Kluwer vol. 92 (9) 
25-01-2019
Multi-ancestry study of blood lipid levels identifies four loci interacting with physical activity
Kilpeläinen TO, Bentley AR, Noordam R, Sung YJ, Schwander K, Winkler TW, Jakupović H, Chasman DI et al.
Nature Communications, Springer Nature vol. 10 (1) 
22-01-2019
Meta-analysis of up to 622,409 individuals identifies 40 novel smoking behaviour associated genetic loci
Erzurumluoglu AM, Liu M, Jackson VE, Barnes DR, Datta G, Melbourne CA, Young R, Batini C et al.
Molecular Psychiatry, Springer Nature vol. 25 (10), 2392-2409.  
07-01-2019
Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation
Ng N, Willems SM, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al.
In Ssrn Electronic Journal 
01-01-2019
Exome Sequencing Identifies Multiple Genes and Gene-Sets Contributing to Severe Childhood Obesity
Marenne G, Hendricks A, Perdikari A, Bounds R, Payne F, Keogh JM, Lelliott CJ, Henning E et al.
In Ssrn Electronic Journal 
01-01-2019
Coding Variant In  LEP Associated with Lower Leptin Concentrations Implicates Leptin in the Regulation of Early Adiposity
Yaghootkar H, Zhang Y, Spracklen CN, Karaderi T, Huang LO, Bradfield J, Schurmann C, Fine RS et al.
In Ssrn Electronic Journal 
01-01-2019
Circulating Protein Biomarkers for Osteoporosis: Results from a Mendelian Randomization Study
Zhou S, Forgetta V, Richards JB, Oerton E, Langenberg C
 
01-01-2019
Variation in the LPL gene, low density lipoprotein-cholesterol lowering alleles and risk of coronary disease and type 2 diabetes
Lotta LA, Stewart I, Sharp S, Day F, Burgess S, Luan J, Cai L, Wittemans L et al.
 
01-01-2019

2018

Associations of Mitochondrial and Nuclear Mitochondrial Variants and Genes with Seven Metabolic Traits
Kraja AT, Liu C, Fetterman JL, Graff M, Have CT, Gu C, Yanek LR, Feitosa MF et al.
American Journal of Human Genetics, Elsevier vol. 104 (1), 112-138.  
27-12-2018
Association of Genetic Variants Related to Gluteofemoral vs Abdominal Fat Distribution With Type 2 Diabetes, Coronary Disease, and Cardiovascular Risk Factors.
Lotta LA, Wittemans LBL, Zuber V, Stewart ID, Sharp SJ, Luan J, Day FR, Li C et al.
Jama: The Journal of The American Medical Association, American Medical Association (Ama) vol. 320 (24), 2553-2563.  
25-12-2018
Trans-ethnic association study of blood pressure determinants in over 750,000 individuals
Giri A, Hellwege JN, Keaton JM, Park J, Qiu C, Warren HR, Torstenson ES, Kovesdy CP et al.
Nature Genetics, Springer Nature vol. 51 (1), 51-62.  
21-12-2018
Exome Chip Meta-analysis Fine Maps Causal Variants and Elucidates the Genetic Architecture of Rare Coding Variants in Smoking and Alcohol Use
Brazel DM, Jiang Y, Hughey JM, Turcot V, Zhan X, Gong J, Batini C, Weissenkampen JD et al.
Biological Psychiatry, Elsevier vol. 85 (11), 946-955.  
06-12-2018
GWAS and colocalization analyses implicate carotid intima-media thickness and carotid plaque loci in cardiovascular outcomes
Franceschini N, Giambartolomei C, de Vries PS, Finan C, Bis JC, Huntley RP, Lovering RC, Tajuddin SM et al.
Nature Communications, Springer Nature vol. 9 (1) 
03-12-2018
Publisher Correction: Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al.
Nature Genetics, Springer Nature vol. 50 (12), 1755-1755.  
14-11-2018
Association of Plasma Vitamin D Metabolites With Incident Type 2 Diabetes: EPIC-InterAct Case-Cohort Study
Zheng J-S, Imamura F, Sharp SJ, van der Schouw YT, Sluijs I, Gundersen TE, Ardanaz E, Boeing H et al.
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society vol. 104 (4), 1293-1303.  
09-11-2018
Author Correction: Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C, Walter K, Min JL, Chen L et al.
Nature Genetics, Springer Nature vol. 50 (12), 1752-1752.  
02-11-2018
Dominant-negative mutations in PPAR alpha are present in unselected human populations and have a metabolic signature
Melvin A, Lam B, Langenberg C, Agostini M, Schoenmakers E, Luan J, Rainbow K, Yeo GS et al.
Endocrine Abstracts, Bioscientifica 
02-11-2018
Genome Analyses of >200,000 Individuals Identify 58 Loci for Chronic Inflammation and Highlight Pathways that Link Inflammation and Complex Disorders
Ligthart S, Vaez A, Võsa U, Stathopoulou MG, de Vries PS, Prins BP, Van der Most PJ, Tanaka T et al.
American Journal of Human Genetics, Elsevier vol. 103 (5), 691-706.  
01-11-2018
Fine-mapping type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
Mahajan A, Taliun D, Thurner M, Robertson NR, Torres JM, Rayner NW, Payne AJ, Steinthorsdottir V et al.
Nature Genetics, Springer Nature vol. 50 (11), 1505-1513.  
08-10-2018
Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies
Do KT, Wahl S, Raffler J, Molnos S, Laimighofer M, Adamski J, Suhre K, Strauch K et al.
Metabolomics, Springer Nature vol. 14 (10) 
20-09-2018
Genetically-enhanced LPL mediated lipolysis, LDL cholesterol lowering alleles and risk of coronary disease and type 2 diabetes
Lotta LA, Stewart ID, Sharp SJ, Day FR, Burgess S, Luan J, Bowker N, Cai L et al.
Jama Cardiology, American Medical Association (Ama) vol. 3 (10), 957-966.  
19-09-2018
Genetic analysis of over 1 million people identifies 535 new loci associated with blood pressure traits
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al.
Nature Genetics, Springer Nature vol. 50 (10), 1412-1425.  
17-09-2018
Type 2 diabetes–associated variants of the MT2 melatonin receptor affect distinct modes of signaling
Karamitri A, Plouffe B, Bonnefond A, Chen M, Gallion J, Guillaume J-L, Hegron A, Boissel M et al.
Science Signaling, American Association For The Advancement of Science (Aaas) vol. 11 (545) 
28-08-2018
Gene discovery and polygenic prediction from a genome-wide association study of educational attainment in 1.1 million individuals
Lee JJ, Wedow R, Okbay A, Kong E, Maghzian O, Zacher M, Nguyen-Viet TA, Bowers P et al.
Nature Genetics, Springer Nature vol. 50 (8), 1112-1121.  
23-07-2018
Genome-wide meta-analysis of macronutrient intake of 91,114 European ancestry participants from the cohorts for heart and aging research in genomic epidemiology consortium
Merino J, Dashti HS, Li SX, Sarnowski C, Justice AE, Graff M, Papoutsakis C, Smith CE et al.
Molecular Psychiatry, Springer Nature vol. 24 (12), 1920-1932.  
09-07-2018
Novel genetic associations for blood pressure identified via gene-alcohol interaction in up to 570K individuals across multiple ancestries
Feitosa MF, Kraja AT, Chasman DI, Sung YJ, Winkler TW, Ntalla I, Guo X, Franceschini N et al.
Plos One, Public Library of Science (Plos) vol. 13 (6) 
18-06-2018
Genomic insights into the causes of type 2 diabetes
Langenberg C, Lotta LA
The Lancet, Elsevier vol. 391 (10138), 2463-2474.  
01-06-2018
Publisher Correction: Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Bonàs-Guarch S, Guindo-Martínez M, Miguel-Escalada I, Grarup N, Sebastian D, Rodriguez-Fos E, Sánchez F, Planas-Fèlix M et al.
Nature Communications, Springer Nature vol. 9 (1) 
30-05-2018
Alcohol intake in relation to non-fatal and fatal coronary heart disease and stroke: EPIC-CVD case-cohort study
Ricci C, Wood A, Muller D, Gunter MJ, Agudo A, Boeing H, van der Schouw YT, Warnakula S et al.
The Bmj, Bmj vol. 361 
29-05-2018
Insights into the genetic epidemiology of Crohn's and rare diseases in the Ashkenazi Jewish population
Rivas MA, Avila BE, Koskela J, Huang H, Stevens C, Pirinen M, Haritunians T, Neale BM et al.
Plos Genetics, Public Library of Science (Plos) vol. 14 (5) 
24-05-2018
Prioritising Risk Factors for Type 2 Diabetes: Causal Inference through Genetic Approaches
Wittemans LBL, Lotta LA, Langenberg C
Current Diabetes Reports, Springer Nature vol. 18 (7) 
19-05-2018
Circulating Selenium and Prostate Cancer Risk: A Mendelian Randomization Analysis
Yarmolinsky J, Bonilla C, Haycock PC, Langdon RJQ, Lotta LA, Langenberg C, Relton CL, Lewis SJ et al.
Journal of The National Cancer Institute, Oxford University Press (Oup) vol. 110 (9), 1035-1038.  
17-05-2018
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
Mahajan A, Wessel J, Willems SM, Zhao W, Robertson NR, Chu AY, Gan W, Kitajima H et al.
Nature Genetics, Springer Nature vol. 50 (4), 559-571.  
01-04-2018
Risk thresholds for alcohol consumption: combined analysis of individual-participant data for 599 912 current drinkers in 83 prospective studies
Wood AM, Kaptoge S, Butterworth AS, Willeit P, Warnakula S, Bolton T, Paige E, Paul DS et al.
The Lancet, Elsevier vol. 391 (10129), 1513-1523.  
01-04-2018
THU-447 Metabolomic patterns associated with known genetic variants for hepatic steatosis and non-alcoholic steatohepatitisidentify biomarkers that may be of utility in predicting adverse liver outcomes
Mann J, Allison M, Wittemans L, Rolfe EDL, Imamura F, Forouhi N, Lotta LA, Griffin JL et al.
Journal of Hepatology, Elsevier vol. 68, s331-s332.  
01-04-2018
Interplay between genetic predisposition, macronutrient intake and type 2 diabetes incidence: analysis within EPIC-InterAct across eight European countries
Li SX, Imamura F, Schulze MB, Zheng J, Ye Z, Agudo A, Ardanaz E, Aune D et al.
Diabetologia, Springer Nature vol. 61 (6), 1325-1332.  
17-03-2018
Publisher Correction: Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al.
Nature Genetics, Springer Nature vol. 50 (5), 765-766.  
16-03-2018
Multiancestry genome-wide association study of 520,000 subjects identifies 32 loci associated with stroke and stroke subtypes
Malik R, Chauhan G, Traylor M, Sargurupremraj M, Okada Y, Mishra A, Rutten-Jacobs L, Giese A-K et al.
Nature Genetics, Springer Nature vol. 50 (4), 524-537.  
12-03-2018
Circulating Fetuin-A and Risk of Type 2 Diabetes: A Mendelian Randomization Analysis
Kröger J, Meidtner K, Stefan N, Guevara M, Kerrison ND, Ardanaz E, Aune D, Boeing H et al.
Diabetes, American Diabetes Association vol. 67 (6) 
09-03-2018
The current and potential health benefits of the National Health Service Health Check cardiovascular disease prevention programme in England: A microsimulation study
Mytton OT, Jackson C, Steinacher A, Goodman A, Langenberg C, Griffin S, Wareham N, Woodcock J
Plos Medicine, Public Library of Science (Plos) vol. 15 (3) 
06-03-2018
A Large-Scale Multi-ancestry Genome-wide Study Accounting for Smoking Behavior Identifies Multiple Significant Loci for Blood Pressure
Sung YJ, Winkler TW, de las Fuentes L, Bentley AR, Brown MR, Kraja AT, Schwander K, Ntalla I et al.
American Journal of Human Genetics, Elsevier vol. 102 (3), 375-400.  
15-02-2018
Erratum: Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R et al.
Scientific Data, Springer Nature vol. 5 (1) 
23-01-2018
Re-analysis of public genetic data reveals a rare X-chromosomal variant associated with type 2 diabetes
Bonàs-Guarch S, Guindo-Martínez M, Miguel-Escalada I, Grarup N, Sebastian D, Rodriguez-Fos E, Sánchez F, Planas-Fèlix M et al.
Nature Communications, Springer Nature vol. 9 (1) 
22-01-2018
Genome-wide association study in 79,366 European-ancestry individuals informs the genetic architecture of 25-hydroxyvitamin D levels
Jiang X, O’Reilly PF, Aschard H, Hsu Y-H, Richards JB, Dupuis J, Ingelsson E, Karasik D et al.
Nature Communications, Springer Nature vol. 9 (1) 
17-01-2018
Life-Course Genome-wide Association Study Meta-analysis of Total Body BMD and Assessment of Age-Specific Effects
Medina-Gomez C, Kemp JP, Trajanoska K, Luan J, Chesi A, Ahluwalia TS, Mook-Kanamori DO, Ham A et al.
American Journal of Human Genetics, Elsevier vol. 102 (1), 88-102.  
01-01-2018
Genomic and epigenetic signatures of mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility
Wright DJ, Day FR, Kerrison ND, Zink F, Cardona A, Sulem P, Thompson DJ, Sigurjonsdottir S et al.
 
01-01-2018
GAD65 autoantibodies are associated with incident diabetes in mid-life: the EPIC-InterAct study
Rolandsson O, Hampe CS, Sharp SJ, Langenberg C, Wareham N
 
01-01-2018
Dominant negative variants in PPAR alpha have a metabolic fingerprint
Melvin A, Lam B, Langenberg C, Luan J, Rainbow K, Yeo GS, Wareham N, Savage DB et al.
 
01-01-2018

2017

Protein-altering variants associated with body mass index implicate pathways that control energy intake and expenditure in obesity
Turcot V, Lu Y, Highland HM, Schurmann C, Justice AE, Fine RS, Bradfield JP, Esko T et al.
Nature Genetics, Springer Nature vol. 50 (1), 26-41.  
22-12-2017
Sequence data and association statistics from 12,940 type 2 diabetes cases and controls
Flannick J, Fuchsberger C, Mahajan A, Teslovich TM, Agarwala V, Gaulton KJ, Caulkins L, Koesterer R et al.
Scientific Data, Springer Nature vol. 4 (1) 
19-12-2017
Elevated Plasma Levels of 3-Hydroxyisobutyric Acid Are Associated With Incident Type 2 Diabetes
Mardinoglu A, Gogg S, Lotta LA, Stančáková A, Nerstedt A, Boren J, Blüher M, Ferrannini E et al.
Ebiomedicine, Elsevier vol. 27, 151-155.  
07-12-2017
Interaction of Dietary and Genetic Factors Influencing Body Iron Status and Risk of Type 2 Diabetes Within the EPIC-InterAct Study
Meidtner K, Podmore C, Kröger J, van der Schouw YT, Bendinelli B, Agnoli C, Arriola L, Barricarte A et al.
Diabetes Care, American Diabetes Association vol. 41 (2) 
22-11-2017
Association between plasma phospholipid saturated fatty acids and metabolic markers of lipid, hepatic, inflammation and glycaemic pathways in eight European countries: a cross-sectional analysis in the EPIC-InterAct study
Zheng J-S, Sharp SJ, Imamura F, Koulman A, Schulze MB, Ye Z, Griffin J, Guevara M et al.
Bmc Medicine, Springer Nature vol. 15 (1) 
17-11-2017
Exome-wide association study of plasma lipids in >300,000 individuals
Liu DJ, Peloso GM, Yu H, Butterworth AS, Wang X, Mahajan A, Saleheen D, Emdin C et al.
Nature Genetics, Springer Nature vol. 49 (12), 1758-1766.  
30-10-2017
A combination of plasma phospholipid fatty acids and its association with incidence of type 2 diabetes: The EPIC-InterAct case-cohort study
Imamura F, Sharp SJ, Koulman A, Schulze MB, Kröger J, Griffin JL, Huerta JM, Guevara M et al.
Plos Medicine, Public Library of Science (Plos) vol. 14 (10) 
11-10-2017
New Blood Pressure–Associated Loci Identified in Meta-Analyses of 475 000 Individuals
Kraja AT, Cook JP, Warren HR, Surendran P, Liu C, Evangelou E, Manning AK, Grarup N et al.
Circulation Genomic and Precision Medicine, Wolters Kluwer vol. 10 (5) 
01-10-2017
Identification of a novel proinsulin-associated SNP and demonstration that proinsulin is unlikely to be a causal factor in subclinical vascular remodelling using Mendelian randomisation
Strawbridge RJ, Silveira A, Hoed MD, Gustafsson S, Luan J, Rybin D, Dupuis J, Li-Gao R et al.
Atherosclerosis, Elsevier vol. 266, 196-204.  
28-09-2017
Impact of common genetic determinants of Hemoglobin A1c on type 2 diabetes risk and diagnosis in ancestrally diverse populations: A transethnic genome-wide meta-analysis
Wheeler E, Leong A, Liu C-T, Hivert M-F, Strawbridge RJ, Podmore C, Li M, Yao J et al.
Plos Medicine, Public Library of Science (Plos) vol. 14 (9) 
12-09-2017
Genome-wide analysis of health-related biomarkers in the UK Household Longitudinal Study reveals novel associations
Prins BP, Kuchenbaecker KB, Bao Y, Smart M, Zabaneh D, Fatemifar G, Luan J, Wareham NJ et al.
Scientific Reports, Springer Nature vol. 7 (1) 
08-09-2017
Correction: Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY et al.
Plos Genetics, Public Library of Science (Plos) vol. 13 (8) 
23-08-2017
Genomic correlates of glatiramer acetate adverse cardiovascular effects lead to a novel locus mediating coronary risk
Brænne I, Zeng L, Willenborg C, Tragante V, Kessler T, Willer CJ, Laakso M, Wallentin L et al.
Plos One, Public Library of Science (Plos) vol. 12 (8) 
22-08-2017
Separate and combined associations of obesity and metabolic health with coronary heart disease: a pan-European case-cohort analysis
Lassale C, Tzoulaki I, Moons KGM, Sweeting M, Boer J, Johnson L, Huerta JM, Agnoli C et al.
European Heart Journal, Oxford University Press (Oup) vol. 39 (5), 397-406.  
14-08-2017
Plasma Mannose Levels Are Associated with Incident Type 2 Diabetes and Cardiovascular Disease
Mardinoglu A, Stančáková A, Lotta LA, Kuusisto J, Boren J, Blüher M, Wareham NJ, Ferrannini E et al.
Cell Metabolism, Elsevier vol. 26 (2), 281-283.  
01-08-2017
Novel Blood Pressure Locus and Gene Discovery Using Genome-Wide Association Study and Expression Data Sets From Blood and the Kidney
Wain LV, Vaez A, Jansen R, Joehanes R, van der Most PJ, Erzurumluoglu AM, O’Reilly PF, Cabrera CP et al.
Hypertension, Wolters Kluwer vol. 70 (3), e4-e19.  
24-07-2017
Large-scale GWAS identifies multiple loci for hand grip strength providing biological insights into muscular fitness
Willems SM, Wright DJ, Day FR, Trajanoska K, Joshi PK, Morris JA, Matteini AM, Garton FC et al.
Nature Communications, Springer Nature vol. 8 (1) 
12-07-2017
Abstract 4238: COnsortium for METabolomics Studies (COMETS): leveraging resources to accelerate scientific discovery
Stolzenberg-Solomon RZ, Moore S, Ulrich C, Poole E, Temprosa M, Verma M, Albanes D, Barrera CB et al.
 
01-07-2017
Type 2 diabetes, glucose, insulin, BMI, and ischemic stroke subtypes
Larsson SC, Scott RA, Traylor M, Langenberg CC, Hindy G, Melander O, Orho-Melander M, Seshadri S et al.
Neurology, Wolters Kluwer vol. 89 (5), 454-460.  
30-06-2017
Rare Variant Analysis of Human and Rodent Obesity Genes in Individuals with Severe Childhood Obesity
Hendricks AE, Bochukova EG, Marenne G, Keogh JM, Atanassova N, Bounds R, Wheeler E, Mistry V et al.
Scientific Reports, Springer Nature vol. 7 (1) 
29-06-2017
Ranking and characterization of established BMI and lipid associated loci as candidates for gene-environment interactions
Shungin D, Deng WQ, Varga TV, Luan J, Mihailov E, Metspalu A, Morris AP, Forouhi NG et al.
Plos Genetics, Public Library of Science (Plos) vol. 13 (6) 
14-06-2017
Interaction between genes and macronutrient intake on the risk of developing type 2 diabetes: systematic review and findings from European Prospective Investigation into Cancer (EPIC)-InterAct
Li SX, Imamura F, Ye Z, Schulze MB, Zheng J, Ardanaz E, Arriola L, Boeing H et al.
American Journal of Clinical Nutrition, Elsevier vol. 106 (1), 263-275.  
07-06-2017
An Expanded Genome-Wide Association Study of Type 2 Diabetes in Europeans
Scott RA, Scott LJ, Mägi R, Marullo L, Gaulton KJ, Kaakinen M, Pervjakova N, Pers TH et al.
Diabetes, American Diabetes Association vol. 66 (11) 
31-05-2017
Whole-Genome Sequencing Coupled to Imputation Discovers Genetic Signals for Anthropometric Traits
Tachmazidou I, Süveges D, Min JL, Ritchie GRS, Steinberg J, Walter K, Iotchkova V, Schwartzentruber J et al.
American Journal of Human Genetics, Elsevier vol. 100 (6), 865-884.  
25-05-2017
Genome-wide association study meta-analysis for quantitative ultrasound parameters of bone identifies five novel loci for broadband ultrasound attenuation
Mullin BH, Zhao JH, Brown SJ, Perry JRB, Luan J, Zheng H-F, Langenberg C, Dudbridge F et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 26 (14), 2791-2802.  
04-05-2017
Genome-wide physical activity interactions in adiposity ― A meta-analysis of 200,452 adults
Graff M, Scott RA, Justice AE, Young KL, Feitosa MF, Barata L, Winkler TW, Chu AY et al.
Plos Genetics, Public Library of Science (Plos) vol. 13 (4) 
27-04-2017
Genome-wide meta-analysis of 241,258 adults accounting for smoking behaviour identifies novel loci for obesity traits
Justice AE, Winkler TW, Feitosa MF, Graff M, Fisher VA, Young K, Barata L, Deng X et al.
Nature Communications, Springer Nature vol. 8 (1) 
26-04-2017
Genomic analyses identify hundreds of variants associated with age at menarche and support a role for puberty timing in cancer risk
Day FR, Thompson DJ, Helgason H, Chasman DI, Finucane H, Sulem P, Ruth KS, Whalen S et al.
Nature Genetics, Springer Nature vol. 49 (6), 834-841.  
24-04-2017
Genetic variants associated with mosaic Y chromosome loss highlight cell cycle genes and overlap with cancer susceptibility
Wright DJ, Day FR, Kerrison ND, Zink F, Cardona A, Sulem P, Thompson DJ, Sigurjonsdottir S et al.
Nature Genetics, Springer Nature vol. 49 (5), 674-679.  
27-03-2017
A Low-Frequency Inactivating Akt2 Variant Enriched in the Finnish Population is Associated With Fasting Insulin Levels and Type 2 Diabetes Risk.
Manning A, Highland HM, Gasser J, Sim X, Tukiainen T, Fontanillas P, Grarup N, Rivas MA et al.
Diabetes, American Diabetes Association vol. 66 (7) 
24-03-2017
Rare and low-frequency coding variants alter human adult height
Marouli E, Graff M, Medina-Gomez C, Lo KS, Wood AR, Kjaer TR, Fine RS, Lu Y et al.
Nature, Springer Nature vol. 542 (7640), 186-190.  
01-02-2017
Erratum: Corrigendum: Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
Lotta LA, Gulati P, Day FR, Payne F, Ongen H, van de Bunt M, Gaulton KJ, Eicher JD et al.
Nature Genetics, Springer Nature vol. 49 (2), 317-317.  
31-01-2017
Genome-wide association analysis identifies novel blood pressure loci and offers biological insights into cardiovascular risk
Nature Genetics, Springer Nature vol. 49 (3), 403-415.  
30-01-2017
ASSOCIATIONS BETWEEN POTENTIALLY MODIFIABLE RISK FACTORS AND ALZHEIMER DISEASE: A MENDELIAN RANDOMIZATION STUDY
Ostergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Day F, Boehme KL, Walter S, Kauwe JS et al.
 
01-01-2017
Pathways to Type 2 Diabetes: Hypothesis-Free Discovery through Integration of Large-Scale Metabolomic and Genomic Data
Lotta L, Newcombe P, Khaw KT, Wareham N, Langenberg C
 
01-01-2017

2016

SOS2 and ACP1 Loci Identified through Large-Scale Exome Chip Analysis Regulate Kidney Development and Function
Li M, Li Y, Weeks O, Mijatovic V, Teumer A, Huffman JE, Tromp G, Fuchsberger C et al.
Journal of The American Society of Nephrology, Wolters Kluwer vol. 28 (3), 981-994.  
05-12-2016
PCSK9 genetic variants and risk of type 2 diabetes: a mendelian randomisation study
Schmidt AF, Swerdlow DI, Holmes MV, Patel RS, Fairhurst-Hunter Z, Lyall DM, Hartwig FP, Horta BL et al.
The Lancet Diabetes & Endocrinology, Elsevier vol. 5 (2), 97-105.  
29-11-2016
Genetic Predisposition to an Impaired Metabolism of the Branched-Chain Amino Acids and Risk of Type 2 Diabetes: A Mendelian Randomisation Analysis
Lotta LA, Scott RA, Sharp SJ, Burgess S, Luan J, Tillin T, Schmidt AF, Imamura F et al.
Plos Medicine, Public Library of Science (Plos) vol. 13 (11) 
29-11-2016
KLB is associated with alcohol drinking, and its gene product β-Klotho is necessary for FGF21 regulation of alcohol preference
Schumann G, Liu C, O'Reilly P, Gao H, Song P, Xu B, Ruggeri B, Amin N et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 113 (50), 14372-14377.  
28-11-2016
A principal component meta-analysis on multiple anthropometric traits identifies novel loci for body shape
Ried JS, Jeff M. J, Chu AY, Bragg-Gresham JL, van Dongen J, Huffman JE, Ahluwalia TS, Cadby G et al.
Nature Communications, Springer Nature vol. 7 (1) 
23-11-2016
Novel genetic loci associated with long-term deterioration in blood lipid concentrations and coronary artery disease in European adults
Varga TV, Kurbasic A, Aine M, Eriksson P, Ali A, Hindy G, Gustafsson S, Luan J et al.
International Journal of Epidemiology, Oxford University Press (Oup) vol. 46 (4), 1211-1222.  
17-11-2016
Integrative genomic analysis implicates limited peripheral adipose storage capacity in the pathogenesis of human insulin resistance
Lotta LA, Gulati P, Day FR, Payne F, Ongen H, van de Bunt M, Gaulton KJ, Eicher JD et al.
Nature Genetics, Springer Nature vol. 49 (1), 17-26.  
14-11-2016
A Systematic Review of Biomarkers and Risk of Incident Type 2 Diabetes: An Overview of Epidemiological, Prediction and Aetiological Research Literature
Abbasi A, Sahlqvist A-S, Lotta L, Brosnan JM, Vollenweider P, Giabbanelli P, Nunez DJ, Waterworth D et al.
Plos One, Public Library of Science (Plos) vol. 11 (10) 
27-10-2016
Association Between Low-Density Lipoprotein Cholesterol–Lowering Genetic Variants and Risk of Type 2 Diabetes: A Meta-analysis
Lotta LA, Sharp SJ, Burgess S, Perry JRB, Stewart ID, Willems SM, Luan J, Ardanaz E et al.
Jama: The Journal of The American Medical Association, American Medical Association (Ama) vol. 316 (13), 1383-1391.  
04-10-2016
Genome-wide associations for birth weight and correlations with adult disease
Horikoshi M, Beaumont RN, Day FR, Warrington NM, Kooijman MN, Fernandez-Tajes J, Feenstra B, van Zuydam NR et al.
Nature, Springer Nature vol. 538 (7624), 248-252.  
28-09-2016
Discovery and refinement of genetic loci associated with cardiometabolic risk using dense imputation maps
Iotchkova V, Huang J, Morris JA, Jain D, Barbieri C, Walter K, Min JL, Chen L et al.
Nature Genetics, Springer Nature vol. 48 (11), 1303-1312.  
26-09-2016
Investigation of gene–diet interactions in the incretin system and risk of type 2 diabetes: the EPIC-InterAct study
The InterAct Consortium
Diabetologia, Springer Nature vol. 59 (12), 2613-2621.  
13-09-2016
Trans-ancestry meta-analyses identify rare and common variants associated with blood pressure and hypertension
Surendran P, Drenos F, Young R, Warren H, Cook JP, Manning AK, Grarup N, Sim X et al.
Nature Genetics, Springer Nature vol. 48 (10), 1151-1161.  
12-09-2016
The genetics of blood pressure regulation and its target organs from association studies in 342,415 individuals
Ehret GB, Ferreira T, Chasman DI, Jackson AU, Schmidt EM, Johnson T, Thorleifsson G, Luan J et al.
Nature Genetics, Springer Nature vol. 48 (10), 1171-1184.  
12-09-2016
Association of Plasma Phospholipid n-3 and n-6 Polyunsaturated Fatty Acids with Type 2 Diabetes: The EPIC-InterAct Case-Cohort Study
Forouhi NG, Imamura F, Sharp SJ, Koulman A, Schulze MB, Zheng J, Ye Z, Sluijs I et al.
Plos Medicine, Public Library of Science (Plos) vol. 13 (7) 
19-07-2016
Genome-Wide Association Study of the Modified Stumvoll Insulin Sensitivity Index Identifies BCL2 and FAM19A2 as Novel Insulin Sensitivity Loci
Walford GA, Gustafsson S, Rybin D, Stančáková A, Chen H, Liu C-T, Hong J, Jensen RA et al.
Diabetes, American Diabetes Association vol. 65 (10), 3200-3211.  
14-07-2016
The genetic architecture of type 2 diabetes
Fuchsberger C, Flannick J, Teslovich TM, Mahajan A, Agarwala V, Gaulton KJ, Ma C, Fontanillas P et al.
Nature, Springer Nature vol. 536 (7614), 41-47.  
11-07-2016
Correction: The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al.
Plos Genetics, Public Library of Science (Plos) vol. 12 (6) 
29-06-2016
Mendelian Randomisation study of the influence of eGFR on coronary heart disease
Charoen P, Nitsch D, Engmann J, Shah T, White J, Zabaneh D, Jefferis B, Wannamethee G et al.
Scientific Reports, Springer Nature vol. 6 (1) 
24-06-2016
Replication and Characterization of Association between ABO SNPs and Red Blood Cell Traits by Meta-Analysis in Europeans
McLachlan S, Giambartolomei C, White J, Charoen P, Wong A, Finan C, Engmann J, Shah T et al.
Plos One, Public Library of Science (Plos) vol. 11 (6) 
09-06-2016
A genomic approach to therapeutic target validation identifies a glucose-lowering GLP1R variant protective for coronary heart disease
Scott RA, Freitag DF, Li L, Chu AY, Surendran P, Young R, Grarup N, Stancáková A et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 8 (341) 
01-06-2016
Genetic Evidence for a Link Between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease
Yaghootkar H, Lotta LA, Tyrrell J, Smit RAJ, Jones SE, Donnelly L, Beaumont R, Campbell A et al.
Diabetes, American Diabetes Association vol. 65 (8), 2448-2460.  
26-04-2016
COnsortium for METabolomics Studies (COMETS): Leveraging Resources to Accelerate Scientific Discovery
Albanes D, Moore S, Ulrich C, Stolzenberg‐Solomon R, Poole E, Temprosa M, Verma M, Boerwinkle E et al.
 
01-04-2016
Rare variant in scavenger receptor BI raises HDL cholesterol and increases risk of coronary heart disease
Zanoni P, Khetarpal SA, Larach DB, Hancock-Cerutti WF, Millar JS, Cuchel M, DerOhannessian S, Kontush A et al.
Science, American Association For The Advancement of Science (Aaas) vol. 351 (6278), 1166-1171.  
11-03-2016
Association of Multiple Biomarkers of Iron Metabolism and Type 2 Diabetes: The EPIC-InterAct Study
Podmore C, Meidtner K, Schulze MB, Scott RA, Ramond A, Butterworth AS, Di Angelantonio E, Danesh J et al.
Diabetes Care, American Diabetes Association vol. 39 (4), 572-581.  
09-02-2016
New loci for body fat percentage reveal link between adiposity and cardiometabolic disease risk
Lu Y, Day FR, Gustafsson S, Buchkovich ML, Na J, Bataille V, Cousminer DL, Dastani Z et al.
Nature Communications, Springer Nature vol. 7 (1) 
01-02-2016
Genome-wide meta-analysis uncovers novel loci influencing circulating leptin levels
Kilpeläinen TO, Carli JFM, Skowronski AA, Sun Q, Kriebel J, Feitosa MF, Hedman ÅK, Drong AW et al.
Nature Communications, Springer Nature vol. 7 (1) 
01-02-2016
Plasma urate concentration and risk of coronary heart disease: a Mendelian randomisation analysis
White J, Sofat R, Hemani G, Shah T, Engmann J, Dale C, Shah S, Kruger FA et al.
The Lancet Diabetes & Endocrinology, Elsevier vol. 4 (4), 327-336.  
16-01-2016
Genetic Evidence for a Link between Favorable Adiposity and Lower Risk of Type 2 Diabetes, Hypertension, and Heart Disease
Yaghootkar H, Lotta L, Tyrrell J, Smit R, Jones S, Donnelly L, Beaumont R, Campbell A et al.
 
01-01-2016
The interaction of insulin resistance and genetically-determined pancreatic response shapes the time trajectories of insulin secretion and glucose tolerance
Luca LA, Scott RA, Sharp SJ, Day FR, Luan J, Wareham NJ, Langenberg C
 
01-01-2016

2015

Correction: Corrigendum: Rare coding variants and X-linked loci associated with age at menarche
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE et al.
Nature Communications, Springer Nature vol. 6 (1) 
17-12-2015
Genome-wide Association Studies Identify Genetic Loci Associated With Albuminuria in Diabetes
Teumer A, Tin A, Sorice R, Gorski M, Yeo NC, Chu AY, Li M, Li Y et al.
Diabetes, American Diabetes Association vol. 65 (3), 803-817.  
02-12-2015
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A et al.
Nature Genetics vol. 47 (12), 1415-1425.  
01-12-2015
Large-Scale Genomic Analyses Link Reproductive Aging to Hypothalamic Signaling, Breast Cancer Susceptibility, and BRCA1-Mediated DNA Repair
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK et al.
Obstetrical & Gynecological Survey, Wolters Kluwer vol. 70 (12), 758-762.  
01-12-2015
Genetic fine mapping and genomic annotation defines causal mechanisms at type 2 diabetes susceptibility loci
Gaulton KJ, Ferreira T, Lee Y, Raimondo A, Mägi R, Reschen ME, Mahajan A, Locke A et al.
Nature Genetics, Springer Nature vol. 47 (12), 1415-1425.  
09-11-2015
Definitions of Metabolic Health and Risk of Future Type 2 Diabetes in BMI Categories: A Systematic Review and Network Meta-analysis
Lotta LA, Abbasi A, Sharp SJ, Sahlqvist A-S, Waterworth D, Brosnan JM, Scott RA, Langenberg C et al.
Diabetes Care, American Diabetes Association vol. 38 (11), 2177-2187.  
12-10-2015
The Influence of Age and Sex on Genetic Associations with Adult Body Size and Shape: A Large-Scale Genome-Wide Interaction Study
Winkler TW, Justice AE, Graff M, Barata L, Feitosa MF, Chu S, Czajkowski J, Esko T et al.
Plos Genetics, Public Library of Science (Plos) vol. 11 (10) 
01-10-2015
Large-scale genomic analyses link reproductive aging to hypothalamic signaling, breast cancer susceptibility and BRCA1-mediated DNA repair
Day FR, Ruth KS, Thompson DJ, Lunetta KL, Pervjakova N, Chasman DI, Stolk L, Finucane HK et al.
Nature Genetics, Springer Nature vol. 47 (11), 1294-1303.  
28-09-2015
Erratum. Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study. Diabetes Care 2014;37:1854–1862
van Nielen M, Feskens EJM, Mensink M, Sluijs I, Molina E, Amiano P, Ardanaz E, Balkau B et al.
Diabetes Care, American Diabetes Association vol. 38 (10), 1992-1992.  
24-09-2015
The UK10K project identifies rare variants in health and disease
Walter K, Min JL, Huang J, Crooks L, Memari Y, McCarthy S, Perry JRB, Xu C et al.
Nature, Springer Nature vol. 526 (7571), 82-90.  
14-09-2015
Improved imputation of low-frequency and rare variants using the UK10K haplotype reference panel
Huang J, Howie B, McCarthy S, Memari Y, Walter K, Min JL, Danecek P, Malerba G et al.
Nature Communications, Springer Nature vol. 6 (1) 
14-09-2015
Rare coding variants and X-linked loci associated with age at menarche
Lunetta KL, Day FR, Sulem P, Ruth KS, Tung JY, Hinds DA, Esko T, Elks CE et al.
Nature Communications, Springer Nature vol. 6 (1) 
04-08-2015
Prevalence and Regional Distribution of Autoantibodies Against GAD65Ab in a European Population Without Diabetes: The EPIC-InterAct Study
Rolandsson O, Hampe CS, Wennberg P, Radtke J, Langenberg C, Wareham N
Diabetes Care, American Diabetes Association vol. 38 (8), e114-e115.  
14-07-2015
Evidence of a Causal Association Between Insulinemia and Endometrial Cancer: A Mendelian Randomization Analysis
Nead KT, Sharp SJ, Thompson DJ, Painter JN, Savage DB, Semple RK, Barker A, Group TANECS et al.
Journal of The National Cancer Institute, Oxford University Press (Oup) vol. 107 (9) 
01-07-2015
Associations between Potentially Modifiable Risk Factors and Alzheimer Disease: A Mendelian Randomization Study
Østergaard SD, Mukherjee S, Sharp SJ, Proitsi P, Lotta LA, Day F, Perry JRB, Boehme KL et al.
Plos Medicine, Public Library of Science (Plos) vol. 12 (6) 
16-06-2015
Dietary fibre and incidence of type 2 diabetes in eight European countries: the EPIC-InterAct Study and a meta-analysis of prospective studies
The InterAct Consortium
Diabetologia, Springer Nature vol. 58 (7), 1394-1408.  
29-05-2015
A Mendelian Randomization Study of Circulating Uric Acid and Type 2 Diabetes
Sluijs I, Holmes MV, van der Schouw YT, Beulens JWJ, Asselbergs FW, Huerta JM, Palmer TM, Arriola L et al.
Diabetes, American Diabetes Association vol. 64 (8), 3028-3036.  
27-04-2015
Genetically Determined Height and Coronary Artery Disease
Nelson CP, Hamby SE, Saleheen D, Hopewell JC, Zeng L, Assimes TL, Kanoni S, Willenborg C et al.
The New England Journal of Medicine, Massachusetts Medical Society vol. 372 (17), 1608-1618.  
08-04-2015
Erratum: Corrigendum: Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D et al.
Nature Communications, Springer Nature vol. 6 (1) 
30-03-2015
Untargeted Metabolic Profiling Identifies Altered Serum Metabolites of Type 2 Diabetes Mellitus in a Prospective, Nested Case Control Study
Drogan D, Dunn WB, Lin W, Buijsse B, Schulze MB, Langenberg C, Brown M, Floegel A et al.
Clinical Chemistry, Oxford University Press (Oup) vol. 61 (3), 487-497.  
01-03-2015
Genetic studies of body mass index yield new insights for obesity biology
Locke AE, Kahali B, Berndt SI, Justice AE, Pers TH, Day FR, Powell C, Vedantam S et al.
Nature, Springer Nature vol. 518 (7538), 197-206.  
11-02-2015
New genetic loci link adipose and insulin biology to body fat distribution
Shungin D, Winkler TW, Croteau-Chonka DC, Ferreira T, Locke AE, Mägi R, Strawbridge RJ, Pers TH et al.
Nature, Springer Nature vol. 518 (7538), 187-196.  
11-02-2015
Type 2 diabetes and incidence of a wide range of cardiovascular diseases: a cohort study in 1·9 million people
Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, Deanfield J, Smeeth L et al.
The Lancet, Elsevier vol. 385 
01-02-2015
Low-frequency and rare exome chip variants associate with fasting glucose and type 2 diabetes susceptibility
Wessel J, Chu AY, Willems SM, Wang S, Yaghootkar H, Brody JA, Dauriz M, Hivert M-F et al.
Nature Communications, Springer Nature vol. 6 (1) 
29-01-2015
Identification and Functional Characterization of G6PC2 Coding Variants Influencing Glycemic Traits Define an Effector Transcript at the G6PC2-ABCB11 Locus
Mahajan A, Sim X, Ng HJ, Manning A, Rivas MA, Highland HM, Locke AE, Grarup N et al.
Plos Genetics, Public Library of Science (Plos) vol. 11 (1) 
27-01-2015
Biological interpretation of genome-wide association studies using predicted gene functions
Pers TH, Karjalainen JM, Chan Y, Westra H-J, Wood AR, Yang J, Lui JC, Vedantam S et al.
Nature Communications, Springer Nature vol. 6 (1) 
19-01-2015

2014

Genetic Markers of Insulin Sensitivity and Insulin Secretion Are Associated With Spontaneous Postnatal Growth and Response to Growth Hormone Treatment in Short SGA Children: the North European SGA Study (NESGAS)
Jensen RB, Thankamony A, Day F, Scott RA, Langenberg C, Kirk J, Donaldson M, Ivarsson S-A et al.
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society vol. 100 (3), e503-e507.  
12-12-2014
Sixty-Five Common Genetic Variants and Prediction of Type 2 Diabetes
Talmud PJ, Cooper JA, Morris RW, Dudbridge F, Shah T, Engmann J, Dale C, White J et al.
Diabetes, American Diabetes Association vol. 64 (5), 1830-1840.  
04-12-2014
Consumption of fatty foods and incident type 2 diabetes in populations from eight European countries
Buijsse B, Boeing H, Drogan D, Schulze MB, Feskens EJ, Amiano P, Barricarte A, Clavel-Chapelon F et al.
European Journal of Clinical Nutrition, Springer Nature vol. 69 (4), 455-461.  
26-11-2014
Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independent of Obesity
Scott RA, Fall T, Pasko D, Barker A, Sharp SJ, Arriola L, Balkau B, Barricarte A et al.
Diabetes, American Diabetes Association vol. 63 (12), 4378-4387.  
13-11-2014
Genetic Evidence for a Normal-Weight “Metabolically Obese” Phenotype Linking Insulin Resistance, Hypertension, Coronary Artery Disease, and Type 2 Diabetes
Yaghootkar H, Scott RA, White CC, Zhang W, Speliotes E, Munroe PB, Ehret GB, Bis JC et al.
Diabetes, American Diabetes Association vol. 63 (12), 4369-4377.  
13-11-2014
Genetic Determinants of Circulating Interleukin-1 Receptor Antagonist Levels and Their Association With Glycemic Traits
Herder C, Nuotio M-L, Shah S, Blankenberg S, Brunner EJ, Carstensen M, Gieger C, Grallert H et al.
Diabetes, American Diabetes Association vol. 63 (12), 4343-4359.  
13-11-2014
Type 2 diabetes and incidence of cardiovascular diseases: a cohort study in 1·9 million people
Shah AD, Langenberg C, Rapsomaniki E, Denaxas S, Pujades-Rodriguez M, Gale CP, Deanfield J, Smeeth L et al.
The Lancet Diabetes & Endocrinology, Elsevier vol. 3 (2), 105-113.  
11-11-2014
Smoking and Long-Term Risk of Type 2 Diabetes: The EPIC-InterAct Study in European Populations
Consortium TI, Spijkerman AMW, van der A DL, Nilsson PM, Ardanaz E, Gavrila D, Agudo A, Arriola L et al.
Diabetes Care, American Diabetes Association vol. 37 (12), 3164-3171.  
08-11-2014
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al.
Nature Genetics vol. 46 (11), 1173-1186.  
05-11-2014
Novel loci affecting iron homeostasis and their effects in individuals at risk for hemochromatosis
Benyamin B, Esko T, Ried JS, Radhakrishnan A, Vermeulen SH, Traglia M, Gögele M, Anderson D et al.
Nature Communications, Springer Nature vol. 5 (1) 
29-10-2014
Defining the role of common variation in the genomic and biological architecture of adult human height
Wood AR, Esko T, Yang J, Vedantam S, Pers TH, Gustafsson S, Chu AY, Estrada K et al.
Nature Genetics, Springer Nature vol. 46 (11), 1173-1186.  
05-10-2014
Association between circulating 25-hydroxyvitamin D and incident type 2 diabetes: a mendelian randomisation study
Ye Z, Sharp SJ, Burgess S, Scott RA, Imamura F, Consortium I, Langenberg C, Wareham NJ et al.
The Lancet Diabetes & Endocrinology, Elsevier vol. 3 (1), 35-42.  
30-09-2014
HMG-coenzyme A reductase inhibition, type 2 diabetes, and bodyweight: evidence from genetic analysis and randomised trials
Swerdlow DI, Preiss D, Kuchenbaecker KB, Holmes MV, Engmann JEL, Shah T, Sofat R, Stender S et al.
The Lancet, Elsevier vol. 385 (9965), 351-361.  
24-09-2014
A systematic review and meta-analysis of 130,000 individuals shows smoking does not modify the association of APOE genotype on risk of coronary heart disease
Holmes MV, Frikke-Schmidt R, Melis D, Luben R, Asselbergs FW, Boer JMA, Cooper J, Palmen J et al.
Atherosclerosis, Elsevier vol. 237 (1), 5-12.  
15-08-2014
Meta-Analysis of Genome-Wide Association Studies in African Americans Provides Insights into the Genetic Architecture of Type 2 Diabetes
Ng MCY, Shriner D, Chen BH, Li J, Chen W-M, Guo X, Liu J, Bielinski SJ et al.
Plos Genetics, Public Library of Science (Plos) vol. 10 (8) 
07-08-2014
Differences in the prospective association between individual plasma phospholipid saturated fatty acids and incident type 2 diabetes: the EPIC-InterAct case-cohort study
Forouhi NG, Koulman A, Sharp SJ, Imamura F, Kröger J, Schulze MB, Crowe FL, Huerta JM et al.
The Lancet Diabetes & Endocrinology, Elsevier vol. 2 (10), 810-818.  
05-08-2014
Novel Approach Identifies SNPs in SLC2A10 and KCNK9 with Evidence for Parent-of-Origin Effect on Body Mass Index
Hoggart CJ, Venturini G, Mangino M, Gomez F, Ascari G, Zhao JH, Teumer A, Winkler TW et al.
Plos Genetics, Public Library of Science (Plos) vol. 10 (7) 
31-07-2014
Parent-of-origin-specific allelic associations among 106 genomic loci for age at menarche
Perry JRB, Day F, Elks CE, Sulem P, Thompson DJ, Ferreira T, He C, Chasman DI et al.
Nature, Springer Nature vol. 514 (7520), 92-97.  
23-07-2014
Association between alcohol and cardiovascular disease: Mendelian randomisation analysis based on individual participant data
Holmes MV, Dale CE, Zuccolo L, Silverwood RJ, Guo Y, Ye Z, Prieto-Merino D, Dehghan A et al.
The Bmj, Bmj vol. 349 (jul10 6) 
10-07-2014
Dietary Protein Intake and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study
van Nielen M, Feskens EJM, Mensink M, Sluijs I, Molina E, Amiano P, Ardanaz E, Balkau B et al.
Diabetes Care, American Diabetes Association vol. 37 (7), 1854-1862.  
12-06-2014
Gene-Lifestyle Interaction and Type 2 Diabetes: The EPIC InterAct Case-Cohort Study
Langenberg C, Sharp SJ, Franks PW, Scott RA, Deloukas P, Forouhi NG, Froguel P, Groop LC et al.
Plos Medicine, Public Library of Science (Plos) vol. 11 (5) 
20-05-2014
Impact of Type 2 Diabetes Susceptibility Variants on Quantitative Glycemic Traits Reveals Mechanistic Heterogeneity
Dimas AS, Lagou V, Barker A, Knowles JW, Mägi R, Hivert M-F, Benazzo A, Rybin D et al.
Diabetes, American Diabetes Association vol. 63 (6), 2158-2171.  
15-05-2014
Quality control and conduct of genome-wide association meta-analyses
Winkler TW, Day FR, Croteau-Chonka DC, Wood AR, Locke AE, Mägi R, Ferreira T, Fall T et al.
Nature Protocols, Springer Nature vol. 9 (5), 1192-1212.  
24-04-2014
A Central Role for GRB10 in Regulation of Islet Function in Man
Prokopenko I, Poon W, Mägi R, B RP, Salehi SA, Almgren P, Osmark P, Bouatia-Naji N et al.
Plos Genetics, Public Library of Science (Plos) vol. 10 (4) 
03-04-2014
Genome-wide trans-ancestry meta-analysis provides insight into the genetic architecture of type 2 diabetes susceptibility
Mahajan A, Go MJ, Zhang W, Below JE, Gaulton KJ, Ferreira T, Horikoshi M, Johnson AD et al.
Nature Genetics, Springer Nature vol. 46 (3), 234-244.  
09-02-2014
Mendelian randomization of blood lipids for coronary heart disease
Holmes MV, Asselbergs FW, Palmer TM, Drenos F, Lanktree MB, Nelson CP, Dale CE, Padmanabhan S et al.
European Heart Journal, Oxford University Press (Oup) vol. 36 (9), 539-550.  
28-01-2014
Components of height and blood pressure in childhood
Regnault N, Kleinman KP, Rifas-Shiman SL, Langenberg C, Lipshultz SE, Gillman MW
International Journal of Epidemiology, Oxford University Press (Oup) vol. 43 (1), 149-159.  
10-01-2014
Genetic Evidence for a Metabolically Obese, Normal Weight Phenotype That Links Insulin Resistance with Type 2 Diabetes, Hypertension, and Coronary Artery Disease
Yaghootkar H, Scott R, White CC, Zhang W, Speliotes EK, Munroe PB, Ehret GB, Bis JC et al.
 
01-01-2014
Leveraging Cross-Species Transcription Factor Binding Site Patterns: From Diabetes Risk Loci to Disease Mechanisms
Claussnitzer M, Dankel SN, Klocke B, Grallert H, Glunk V, Berulava T, Lee H, Oskolkov N et al.
Cell, Elsevier vol. 156 (1-2), 343-358.  
01-01-2014
Common Genetic Variants Highlight the Role of Insulin Resistance and Body Fat Distribution in Type 2 Diabetes, Independently of Obesity
Scott RA, Fall T, Pasko D, Barker A, Sharp SJ, Giedraitis V, Walker M, Semple RK et al.
 
01-01-2014

2013

Dietary Intakes of Individual Flavanols and Flavonols Are Inversely Associated with Incident Type 2 Diabetes in European Populations 1–3
Zamora-Ros R, Forouhi NG, Sharp SJ, González CA, Buijsse B, Guevara M, van der Schouw YT, Amiano P et al.
Journal of Nutrition, Elsevier vol. 144 (3), 335-343.  
24-12-2013
Dietary vitamin D intake and risk of type 2 diabetes in the European Prospective Investigation into Cancer and Nutrition: the EPIC-InterAct study
Abbas S, Linseisen J, Rohrmann S, Beulens JWJ, Buijsse B, Amiano P, Ardanaz E, Balkau B et al.
European Journal of Clinical Nutrition, Springer Nature vol. 68 (2), 196-202.  
20-11-2013
The Association Between Dietary Flavonoid and Lignan Intakes and Incident Type 2 Diabetes in European Populations The EPIC-InterAct study
Zamora-Ros R, Forouhi NG, Sharp SJ, González CA, Buijsse B, Guevara M, van der Schouw YT, Amiano P et al.
Diabetes Care, American Diabetes Association vol. 36 (12), 3961-3970.  
13-11-2013
Adherence to predefined dietary patterns and incident type 2 diabetes in European populations: EPIC-InterAct Study
The InterAct Consortium
Diabetologia, Springer Nature vol. 57 (2), 321-333.  
07-11-2013
Common variants associated with plasma triglycerides and risk for coronary artery disease
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al.
Nature Genetics vol. 45 (11), 1345-1353.  
01-11-2013
Age at Menarche and Type 2 Diabetes Risk
Elks CE, Ong KK, Scott RA, van der Schouw YT, Brand JS, Wark PA, Amiano P, Balkau B et al.
Diabetes Care, American Diabetes Association vol. 36 (11), 3526-3534.  
15-10-2013
Non-invasive risk scores for prediction of type 2 diabetes (EPIC-InterAct): a validation of existing models
Kengne AP, Beulens JW, Peelen LM, Moons KG, van der Schouw YT, Schulze MB, Spijkerman AM, Griffin SJ et al.
The Lancet Diabetes & Endocrinology, Elsevier vol. 2 (1), 19-29.  
08-10-2013
Discovery and refinement of loci associated with lipid levels
Willer CJ, Schmidt EM, Sengupta S, Peloso GM, Gustafsson S, Kanoni S, Ganna A, Chen J et al.
Nature Genetics, Springer Nature vol. 45 (11), 1274-1283.  
06-10-2013
Common variants associated with plasma triglycerides and risk for coronary artery disease
Do R, Willer CJ, Schmidt EM, Sengupta S, Gao C, Peloso GM, Gustafsson S, Kanoni S et al.
Nature Genetics, Springer Nature vol. 45 (11), 1345-1352.  
06-10-2013
The SH2B1 obesity locus and abnormal glucose homeostasis: Lack of evidence for association from a meta-analysis in individuals of European ancestry
Prudente S, Copetti M, Morini E, Mendonca C, Andreozzi F, Chandalia M, Baratta R, consortium TD et al.
Nutrition Metabolism and Cardiovascular Diseases, Elsevier vol. 23 (11), 1043-1049.  
05-10-2013
Mendelian Randomization Studies Do Not Support a Causal Role for Reduced Circulating Adiponectin Levels in Insulin Resistance and Type 2 Diabetes
Yaghootkar H, Lamina C, Scott RA, Dastani Z, Hivert M-F, Warren LL, Stancáková A, Buxbaum SG et al.
Diabetes, American Diabetes Association vol. 62 (10), 3589-3598.  
17-09-2013
Population Genomics of Cardiometabolic Traits: Design of the University College London-London School of Hygiene and Tropical Medicine-Edinburgh-Bristol (UCLEB) Consortium
Shah T, Engmann J, Dale C, Shah S, White J, Giambartolomei C, McLachlan S, Zabaneh D et al.
Plos One, Public Library of Science (Plos) vol. 8 (8) 
20-08-2013
Genome-wide association study identifies three novel loci for type 2 diabetes
Hara K, Fujita H, Johnson TA, Yamauchi T, Yasuda K, Horikoshi M, Peng C, Hu C et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 23 (1), 239-246.  
14-08-2013
Meta-analysis of Gene-Level Associations for Rare Variants Based on Single-Variant Statistics
Hu Y-J, Berndt SI, Gustafsson S, Ganna A, Consortium GIOAT, Berndt SI, Gustafsson S, Mägi R et al.
American Journal of Human Genetics, Elsevier vol. 93 (2), 236-248.  
25-07-2013
Sex-stratified Genome-wide Association Studies Including 270,000 Individuals Show Sexual Dimorphism in Genetic Loci for Anthropometric Traits
Randall JC, Winkler TW, Kutalik Z, Berndt SI, Jackson AU, Monda KL, Kilpeläinen TO, Esko T et al.
Plos Genetics, Public Library of Science (Plos) vol. 9 (6) 
01-06-2013
The association of the mitochondrial DNA OriB variant (16184–16193 polycytosine tract) with type 2 diabetes in Europid populations
Ye Z, Gillson C, Sims M, Khaw K-T, Plotka M, Poulton J, Langenberg C, Wareham NJ
Diabetologia, Springer Nature vol. 56 (9), 1907-1913.  
24-05-2013
Genome-wide meta-analysis of observational studies shows common genetic variants associated with macronutrient intake 1 , 2 , 3 , 4
Tanaka T, Ngwa JS, van Rooij FJA, Zillikens MC, Wojczynski MK, Frazier-Wood AC, Houston DK, Kanoni S et al.
American Journal of Clinical Nutrition, Elsevier vol. 97 (6), 1395-1402.  
01-05-2013
Consumption of sweet beverages and type 2 diabetes incidence in European adults: results from EPIC-InterAct
The InterAct consortium
Diabetologia, Springer Nature vol. 56 (7), 1520-1530.  
26-04-2013
The shared allelic architecture of adiponectin levels and coronary artery disease
Dastani Z, Johnson T, Kronenberg F, Nelson CP, Assimes TL, März W, Consortium C, Consortium A et al.
Atherosclerosis, Elsevier vol. 229 (1), 145-148.  
22-04-2013
Genome-Wide Association Study Identifies a Novel Locus Contributing to Type 2 Diabetes Susceptibility in Sikhs of Punjabi Origin From India
Saxena R, Saleheen D, Been LF, Garavito ML, Braun T, Bjonnes A, Young R, Ho WK et al.
Diabetes, American Diabetes Association vol. 62 (5), 1746-1755.  
16-04-2013
Identification of heart rate–associated loci and their effects on cardiac conduction and rhythm disorders
den Hoed M, Eijgelsheim M, Esko T, Brundel BJJM, Peal DS, Evans DM, Nolte IM, Segrè AV et al.
Nature Genetics, Springer Nature vol. 45 (6), 621-631.  
14-04-2013
Maps of open chromatin highlight cell type–restricted patterns of regulatory sequence variation at hematological trait loci
Paul DS, Albers CA, Rendon A, Voss K, Stephens J, Consortium H, van der Harst P, Chambers JC et al.
Genome Research, Cold Spring Harbor Laboratory vol. 23 (7), 1130-1141.  
09-04-2013
Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture
Berndt SI, Gustafsson S, Mägi R, Ganna A, Wheeler E, Feitosa MF, Justice AE, Monda KL et al.
Nature Genetics, Springer Nature vol. 45 (5), 501-512.  
07-04-2013
Corrigendum
Journal of Internal Medicine, Wiley vol. 273 (4), 422-422.  
20-03-2013
Age at Menopause, Reproductive Life Span, and Type 2 Diabetes Risk Results from the EPIC-InterAct study
Brand JS, van der Schouw YT, Onland-Moret NC, Sharp SJ, Ong KK, Khaw K-T, Ardanaz E, Amiano P et al.
Diabetes Care, American Diabetes Association vol. 36 (4), 1012-1019.  
14-03-2013
Seropositivity and Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Mortality in the Population-Based European Prospective Investigation of Cancer–Norfolk Cohort
Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw K-T, Wareham NJ
Clinical Infectious Diseases, Oxford University Press (Oup) vol. 56 (10), 1421-1427.  
26-02-2013
Use of low-density lipoprotein cholesterol gene score to distinguish patients with polygenic and monogenic familial hypercholesterolaemia: a case-control study
Talmud PJ, Shah S, Whittall R, Futema M, Howard P, Cooper JA, Harrison SC, Li K et al.
The Lancet, Elsevier vol. 381 (9874), 1293-1301.  
22-02-2013
Genome-Wide Association Study for Type 2 Diabetes in Indians Identifies a New Susceptibility Locus at 2q21
Tabassum R, Chauhan G, Dwivedi OP, Mahajan A, Jaiswal A, Kaur I, Bandesh K, Singh T et al.
Diabetes, American Diabetes Association vol. 62 (3), 977-986.  
14-02-2013
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D et al.
Nature Genetics vol. 45 (2), 145-154.  
01-02-2013
Distribution and determinants of circulating complement factor H concentration determined by a high-throughput immunonephelometric assay
Sofat R, Mangione PP, Gallimore JR, Hakobyan S, Hughes TR, Shah T, Goodship T, D'Aiuto F et al.
Journal of Immunological Methods, Elsevier vol. 390 (1-2), 63-73.  
30-01-2013
Lipoprotein receptor-related protein 1 variants and dietary fatty acids: meta-analysis of European origin and African American studies
Smith CE, Ngwa J, Tanaka T, Qi Q, Wojczynski MK, Lemaitre RN, Anderson JS, Manichaikul A et al.
International Journal of Obesity, Springer Nature vol. 37 (9), 1211-1220.  
29-01-2013
A genetic risk score comprising common variants associated with fasting insulin is associated with OGTT- and clamp-based indices of whole body insulin sensitivity
Scott RA, Pasko D, Fall T, Yaghootkar H, Barker A, Sharp SJ, Walker M, Wareham NJ et al.
 
01-01-2013
Self-rated health and type 2 diabetes risk in the European Prospective Investigation into Cancer and Nutrition-InterAct study: a case-cohort study
Wennberg P, Rolandsson O, van der A DL, Spijkerman AMW, Kaaks R, Boeing H, Feller S, Bergmann MM et al.
Bmj Open, Bmj vol. 3 (3) 
01-01-2013
Gene × Physical Activity Interactions in Obesity: Combined Analysis of 111,421 Individuals of European Ancestry
Ahmad S, Rukh G, Varga TV, Ali A, Kurbasic A, Shungin D, Ericson U, Koivula RW et al.
Plos Genetics, Public Library of Science (Plos) vol. 9 (7) 
01-01-2013
The Association between Dietary Energy Density and Type 2 Diabetes in Europe: Results from the EPIC-InterAct Study
van den Berg SW, van der A DL, Spijkerman AMW, van Woudenbergh GJ, Tijhuis MJ, Amiano P, Ardanaz E, Beulens JWJ et al.
Plos One, Public Library of Science (Plos) vol. 8 (5) 
01-01-2013

2012

Causal Relevance of Blood Lipid Fractions in the Development of Carotid Atherosclerosis
Shah S, Casas J-P, Drenos F, Whittaker J, Deanfield J, Swerdlow DI, Holmes MV, Kivimaki M et al.
Circulation Genomic and Precision Medicine, Wolters Kluwer vol. 6 (1), 63-72.  
28-12-2012
Genome-wide association analyses identify 18 new loci associated with serum urate concentrations
Köttgen A, Albrecht E, Teumer A, Vitart V, Krumsiek J, Hundertmark C, Pistis G, Ruggiero D et al.
Nature Genetics, Springer Nature vol. 45 (2), 145-154.  
23-12-2012
A Genome-Wide Association Study Identifies GRK5 and RASGRP1 as Type 2 Diabetes Loci in Chinese Hans
Li H, Gan W, Lu L, Dong X, Han X, Hu C, Yang Z, Sun L et al.
Diabetes, American Diabetes Association vol. 62 (1), 291-298.  
13-12-2012
Large-scale association analysis identifies new risk loci for coronary artery disease
Deloukas P, Kanoni S, Willenborg C, Farrall M, Assimes TL, Thompson JR, Ingelsson E, Saleheen D et al.
Nature Genetics, Springer Nature vol. 45 (1), 25-33.  
02-12-2012
Seventy-five genetic loci influencing the human red blood cell
van der Harst P, Zhang W, Mateo Leach I, Rendon A, Verweij N, Sehmi J, Paul DS, Elling U et al.
Nature, Springer Nature vol. 492 (7429), 369-375.  
01-12-2012
Dietary Glycemic Index, Glycemic Load, and Digestible Carbohydrate Intake Are Not Associated with Risk of Type 2 Diabetes in Eight European Countries
consortium OBOTI, Sluijs I, Beulens JWJ, van der Schouw YT, van der A DL, Buckland G, Kuijsten A, Schulze MB et al.
Journal of Nutrition, Elsevier vol. 143 (1), 93-99.  
28-11-2012
Exome sequencing-driven discovery of coding polymorphisms associated with common metabolic phenotypes
Albrechtsen A, Grarup N, Li Y, Sparsø T, Tian G, Cao H, Jiang T, Kim SY et al.
Diabetologia, Springer Nature vol. 56 (2), 298-310.  
19-11-2012
Identification of the BCAR1-CFDP1-TMEM170A Locus as a Determinant of Carotid Intima-Media Thickness and Coronary Artery Disease Risk
Gertow K, Sennblad B, Strawbridge RJ, Ohrvik J, Zabaneh D, Shah S, Veglia F, Fava C et al.
Circulation Genomic and Precision Medicine, Wolters Kluwer vol. 5 (6), 656-665.  
14-11-2012
Abstract B76: Evidence of a causal association between fasting insulin concentrations and endometrial cancer: A Mendelian randomization analysis
Nead KT, Scott RA, Sharp SA, Butterworth AS, Thompson DJ, Johnson T, Spurdle AB, Pharoah PD et al.
Cancer Prevention Research, American Association For Cancer Research (Aacr) vol. 5 (11_Supplement), b76-b76.  
01-11-2012
Higher Immunoglobulin G Antibody Levels Against Cytomegalovirus Are Associated With Incident Ischemic Heart Disease in the Population-Based EPIC-Norfolk Cohort
Gkrania-Klotsas E, Langenberg C, Sharp SJ, Luben R, Khaw K-T, Wareham NJ
Journal of Infectious Diseases, Oxford University Press (Oup) vol. 206 (12), 1897-1903.  
08-10-2012
The link between family history and risk of type 2 diabetes is not explained by anthropometric, lifestyle or genetic risk factors: the EPIC-InterAct study
The InterAct Consortium
Diabetologia, Springer Nature vol. 56 (1), 60-69.  
28-09-2012
Association between dietary meat consumption and incident type 2 diabetes: the EPIC-InterAct study
The InterAct Consortium
Diabetologia, Springer Nature vol. 56 (1), 47-59.  
16-09-2012
A GWAS sequence variant for platelet volume marks an alternative DNM3 promoter in megakaryocytes near a MEIS1 binding site
Nürnberg ST, Rendon A, Smethurst PA, Paul DS, Voss K, Thon JN, Lloyd-Jones H, Sambrook JG et al.
Blood, American Society of Hematology vol. 120 (24), 4859-4868.  
12-09-2012
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, MäGi R, Strawbridge RJ et al.
Nature Genetics vol. 44 (9), 991-1005.  
01-09-2012
Large-scale association analyses identify new loci influencing glycemic traits and provide insight into the underlying biological pathways
Scott RA, Lagou V, Welch RP, Wheeler E, Montasser ME, Luan J, Mägi R, Strawbridge RJ et al.
Nature Genetics, Springer Nature vol. 44 (9), 991-1005.  
12-08-2012
Large-scale association analysis provides insights into the genetic architecture and pathophysiology of type 2 diabetes
Morris AP, Voight BF, Teslovich TM, Ferreira T, Segré AV, Steinthorsdottir V, Strawbridge RJ, Khan H et al.
Nature Genetics, Springer Nature vol. 44 (9), 981-990.  
12-08-2012
Fruit and vegetable intake and type 2 diabetes: EPIC-InterAct prospective study and meta-analysis
Cooper AJ, Forouhi NG, Ye Z, Buijsse B, Arriola L, Balkau B, Barricarte A, Beulens JWJ et al.
European Journal of Clinical Nutrition, Springer Nature vol. 66 (10), 1082-1092.  
01-08-2012
Impact of Common Variation in Bone-Related Genes on Type 2 Diabetes and Related Traits
Billings LK, Hsu Y-H, Ackerman RJ, Dupuis J, Voight BF, Rasmussen-Torvik LJ, Hercberg S, Lathrop M et al.
Diabetes, American Diabetes Association vol. 61 (8), 2176-2186.  
17-07-2012
Meta-analysis identifies multiple loci associated with kidney function–related traits in east Asian populations
Okada Y, Sim X, Go MJ, Wu J-Y, Gu D, Takeuchi F, Takahashi A, Maeda S et al.
Nature Genetics, Springer Nature vol. 44 (8), 904-909.  
15-07-2012
The amount and type of dairy product intake and incident type 2 diabetes: results from the EPIC-InterAct Study
Sluijs I, Forouhi NG, Beulens JW, van der Schouw YT, Agnoli C, Arriola L, Balkau B, Barricarte A et al.
American Journal of Clinical Nutrition, Elsevier vol. 96 (2), 382-390.  
03-07-2012
Lower educational level is a predictor of incident type 2 diabetes in European countries: The EPIC-InterAct study
Sacerdote C, Ricceri F, Rolandsson O, Baldi I, Chirlaque M-D, Feskens E, Bendinelli B, Ardanaz E et al.
International Journal of Epidemiology, Oxford University Press (Oup) vol. 41 (4), 1162-1173.  
25-06-2012
A genome-wide approach accounting for body mass index identifies genetic variants influencing fasting glycemic traits and insulin resistance
Manning AK, Hivert M-F, Scott RA, Grimsby JL, Bouatia-Naji N, Chen H, Rybin D, Liu C-T et al.
Nature Genetics, Springer Nature vol. 44 (6), 659-669.  
13-05-2012
The prospective association between total and type of fish intake and type 2 diabetes in 8 European countries: EPIC-InterAct Study
Patel PS, Forouhi NG, Kuijsten A, Schulze MB, van Woudenbergh GJ, Ardanaz E, Amiano P, Arriola L et al.
American Journal of Clinical Nutrition, Elsevier vol. 95 (6), 1445-1453.  
09-05-2012
Alcohol consumption and risk of type 2 diabetes in European men and women: influence of beverage type and body sizeThe EPIC–InterAct study
Beulens JWJ, van der Schouw YT, Bergmann MM, Rohrmann S, Schulze MB, Buijsse B, Grobbee DE, Arriola L et al.
Journal of Internal Medicine, Wiley vol. 272 (4), 358-370.  
08-05-2012
Stratifying Type 2 Diabetes Cases by BMI Identifies Genetic Risk Variants in LAMA1 and Enrichment for Risk Variants in Lean Compared to Obese Cases
Perry JRB, Voight BF, Yengo L, Amin N, Dupuis J, Ganser M, Grallert H, Navarro P et al.
Plos Genetics, Public Library of Science (Plos) vol. 8 (5) 
01-05-2012
Physical activity reduces the risk of incident type 2 diabetes in general and in abdominally lean and obese men and women: the EPIC–InterAct Study
The InterAct Consortium
Diabetologia, Springer Nature vol. 55 (7), 1944-1952.  
21-04-2012
Circulating 25-hydroxyvitamin D concentration and the risk of type 2 diabetes: results from the European Prospective Investigation into Cancer (EPIC)-Norfolk cohort and updated meta-analysis of prospective studies
Forouhi NG, Ye Z, Rickard AP, Khaw KT, Luben R, Langenberg C, Wareham NJ
Diabetologia, Springer Nature vol. 55 (8), 2173-2182.  
15-04-2012
No Interactions Between Previously Associated 2-Hour Glucose Gene Variants and Physical Activity or BMI on 2-Hour Glucose Levels
Scott RA, Chu AY, Grarup N, Manning AK, Hivert M-F, Shungin D, Tönjes A, Yesupriya A et al.
Diabetes, American Diabetes Association vol. 61 (5), 1291-1296.  
13-04-2012
Genetic determinants of glucose homeostasis
Barker A, Langenberg C, Wareham NJ
Best Practice & Research Clinical Endocrinology & Metabolism, Elsevier vol. 26 (2), 159-170.  
01-04-2012
A single-nucleotide polymorphism in ANK1 is associated with susceptibility to type 2 diabetes in Japanese populations
Imamura M, Maeda S, Yamauchi T, Hara K, Yasuda K, Morizono T, Takahashi A, Horikoshi M et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 21 (13), 3042-3049.  
28-03-2012
Bayesian inference analyses of the polygenic architecture of rheumatoid arthritis
Stahl EA, Wegmann D, Trynka G, Gutierrez-Achury J, Do R, Voight BF, Kraft P, Chen R et al.
Nature Genetics, Springer Nature vol. 44 (5), 483-489.  
25-03-2012
Evaluation of common genetic variants identified by GWAS for early onset and morbid obesity in population-based samples
den Hoed M, Luan J, Langenberg C, Cooper C, Sayer AA, Jameson K, Kumari M, Kivimaki M et al.
International Journal of Obesity, Springer Nature vol. 37 (2), 191-196.  
20-03-2012
P128 Identification de nouveaux polymorphismes génétiques associés au risque de diabète de type 2 chez les obèses et non obèses européens
Cauchi S, Perry J, Almgren P, Scott R, Langenberg C, Wareham N, Groop L, Frayling T et al.
 
01-03-2012
The interleukin-6 receptor as a target for prevention of coronary heart disease: a mendelian randomisation analysis
Swerdlow DI, Holmes MV, Kuchenbaecker KB, Engmann JEL, Shah T, Sofat R, Guo Y, Chung C et al.
The Lancet, Elsevier vol. 379 (9822), 1214-1224.  
01-03-2012
Rare MTNR1B variants impairing melatonin receptor 1B function contribute to type 2 diabetes
Bonnefond A, Clément N, Fawcett K, Yengo L, Vaillant E, Guillaume J-L, Dechaume A, Payne F et al.
Nature Genetics, Springer Nature vol. 44 (3), 297-301.  
29-01-2012
Low-Frequency Variants in HMGA1 Are Not Associated With Type 2 Diabetes Risk
Marquez M, Huyvaert M, Perry JRB, Pearson RD, Falchi M, Morris AP, Vivequin S, Lobbens S et al.
Diabetes, American Diabetes Association vol. 61 (2), 524-530.  
17-01-2012
The association between prior infection with five serotypes of Coxsackievirus B and incident type 2 diabetes mellitus in the EPIC-Norfolk study
Gkrania-Klotsas E, Langenberg C, Tauriainen S, Sharp SJ, Luben R, Forouhi NG, Khaw KT, Hyöty H et al.
Diabetologia, Springer Nature vol. 55 (4), 967-970.  
10-01-2012
A Genome-Wide Association Search for Type 2 Diabetes Genes in African Americans
Palmer ND, McDonough CW, Hicks PJ, Roh BH, Wing MR, An SS, Hester JM, Cooke JN et al.
Plos One, Public Library of Science (Plos) vol. 7 (1) 
01-01-2012
Novel Loci for Adiponectin Levels and Their Influence on Type 2 Diabetes and Metabolic Traits: A Multi-Ethnic Meta-Analysis of 45,891 Individuals
Dastani Z, Hivert M-F, Timpson N, Perry JRB, Yuan X, Scott RA, Henneman P, Heid IM et al.
Plos Genetics, Public Library of Science (Plos) vol. 8 (3) 
01-01-2012
Circadian Gene Variants and Susceptibility to Type 2 Diabetes: A Pilot Study
Kelly MA, Rees SD, Hydrie MZI, Shera AS, Bellary S, O’Hare JP, Kumar S, Taheri S et al.
Plos One, Public Library of Science (Plos) vol. 7 (4) 
01-01-2012
Genome-Wide Association for Abdominal Subcutaneous and Visceral Adipose Reveals a Novel Locus for Visceral Fat in Women
Fox CS, Liu Y, White CC, Feitosa M, Smith AV, Heard-Costa N, Lohman K, Johnson AD et al.
Plos Genetics, Public Library of Science (Plos) vol. 8 (5) 
01-01-2012
Mendelian Randomization Studies to Understand the Role for Reduced Adiponectin Levels in Insulin Resistance or Type 2 Diabetes
Yaghootkar H, Warren L, Lawlor D, Scott R, Dastani Z, Hivert M-F, Henneman P, Langenberg C et al.
 
01-01-2012
Tea Consumption and Incidence of Type 2 Diabetes in Europe: The EPIC-InterAct Case-Cohort Study
van Woudenbergh GJ, Kuijsten A, Drogan D, van der A DL, Romaguera D, Ardanaz E, Amiano P, Barricarte A et al.
Plos One, Public Library of Science (Plos) vol. 7 (5) 
01-01-2012
Long-Term Risk of Incident Type 2 Diabetes and Measures of Overall and Regional Obesity: The EPIC-InterAct Case-Cohort Study
Langenberg C, Sharp SJ, Schulze MB, Rolandsson O, Overvad K, Forouhi NG, Spranger J, Drogan D et al.
Plos Medicine, Public Library of Science (Plos) vol. 9 (6) 
01-01-2012
Genome-Wide Association Study Identifies Novel Loci Associated with Circulating Phospho- and Sphingolipid Concentrations
Demirkan A, van Duijn CM, Ugocsai P, Isaacs A, Pramstaller PP, Liebisch G, Wilson JF, Johansson Å et al.
Plos Genetics, Public Library of Science (Plos) vol. 8 (2) 
01-01-2012
The association of the mitochondrial DNA 16184-16193 poly-C variant with type 2 diabetes
Langenberg C, Ye Z, Gillson C, Plotka M, Khaw K-T, Poulton J, Wareham NJ
 
01-01-2012
Impact of Type 2 Diabetes Susceptibility Loci on Variation in Physiologic Glycaemic Traits in Non-Diabetic Individuals
Dimas AS, Gomes VI, Knowles J, Maegi R, Barker A, Hivert M-F, Benazzo A, Rybin D et al.
 
01-01-2012

2011

Meta-analysis of genome-wide association studies identifies eight new loci for type 2 diabetes in east Asians
Cho YS, Chen C-H, Hu C, Long J, Hee Ong RT, Sim X, Takeuchi F, Wu Y et al.
Nature Genetics, Springer Nature vol. 44 (1), 67-72.  
11-12-2011
New gene functions in megakaryopoiesis and platelet formation
Gieger C, Radhakrishnan A, Cvejic A, Tang W, Porcu E, Pistis G, Serbanovic-Canic J, Elling U et al.
Nature, Springer Nature vol. 480 (7376), 201-208.  
30-11-2011
Validity of a short questionnaire to assess physical activity in 10 European countries
The InterAct Consortium
European Journal of Epidemiology, Springer Nature vol. 27 (1), 15-25.  
17-11-2011
Abdominal aortic aneurysm is associated with a variant in low-density lipoprotein receptor-related protein 1
Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA et al.
American Journal of Human Genetics vol. 89 (5), 619-627.  
11-11-2011
Abdominal Aortic Aneurysm Is Associated with a Variant in Low-Density Lipoprotein Receptor-Related Protein 1
Bown MJ, Jones GT, Harrison SC, Wright BJ, Bumpstead S, Baas AF, Gretarsdottir S, Badger SA et al.
American Journal of Human Genetics, Elsevier vol. 89 (5), 619-627.  
01-11-2011
Genome-wide association study identifies loci influencing concentrations of liver enzymes in plasma
Chambers JC, Zhang W, Sehmi J, Li X, Wass MN, Van der Harst P, Holm H, Sanna S et al.
Nature Genetics, Springer Nature vol. 43 (11), 1131-1138.  
16-10-2011
Mendelian Randomization Study of B-Type Natriuretic Peptide and Type 2 Diabetes: Evidence of Causal Association from Population Studies
Pfister R, Sharp S, Luben R, Welsh P, Barroso I, Salomaa V, Meirhaeghe A, Khaw K-T et al.
Plos Medicine, Public Library of Science (Plos) vol. 8 (10) 
01-10-2011
Genome-Wide Association Identifies Nine Common Variants Associated With Fasting Proinsulin Levels and Provides New Insights Into the Pathophysiology of Type 2 Diabetes
Strawbridge RJ, Dupuis J, Prokopenko I, Barker A, Ahlqvist E, Rybin D, Petrie JR, Travers ME et al.
Diabetes, American Diabetes Association vol. 60 (10), 2624-2634.  
16-09-2011
The Lin28/let-7 Axis Regulates Glucose Metabolism
Zhu H, Shyh-Chang N, Segrè AV, Shinoda, Shah SP, Einhorn WS, Takeuchi A, Engreitz JM et al.
Cell, Elsevier vol. 147 (1), 81-94.  
01-09-2011
Total Zinc Intake May Modify the Glucose-Raising Effect of a Zinc Transporter (SLC30A8) Variant A 14-Cohort Meta-analysis
Kanoni S, Nettleton JA, Hivert M-F, Ye Z, van Rooij FJA, Shungin D, Sonestedt E, Ngwa JS et al.
Diabetes, American Diabetes Association vol. 60 (9), 2407-2416.  
20-08-2011
Mediterranean Diet and Type 2 Diabetes Risk in the European Prospective Investigation Into Cancer and Nutrition (EPIC) Study The InterAct project
Romaguera D, Guevara M, Norat T, Langenberg C, Forouhi NG, Sharp S, Slimani N, Schulze MB et al.
Diabetes Care, American Diabetes Association vol. 34 (9), 1913-1918.  
19-08-2011
Design and cohort description of the InterAct Project: an examination of the interaction of genetic and lifestyle factors on the incidence of type 2 diabetes in the EPIC Study
The InterAct Consortium
Diabetologia, Springer Nature vol. 54 (9) 
30-06-2011
No evidence for a causal link between uric acid and type 2 diabetes: a Mendelian randomisation approach
Pfister R, Barnes D, Luben R, Forouhi NG, Bochud M, Khaw K-T, Wareham NJ, Langenberg C
Diabetologia, Springer Nature vol. 54 (10), 2561-2569.  
30-06-2011
Genetic variation near IRS1 associates with reduced adiposity and an impaired metabolic profile
Kilpeläinen TO, Zillikens MC, Stančákova A, Finucane FM, Ried JS, Langenberg C, Zhang W, Beckmann JS et al.
Nature Genetics, Springer Nature vol. 43 (8), 753-760.  
26-06-2011
Individual and cumulative effect of type 2 diabetes genetic susceptibility variants on risk of coronary heart disease
Pfister R, Barnes D, Luben RN, Khaw K-T, Wareham NJ, Langenberg C
Diabetologia, Springer Nature vol. 54 (9), 2283-2287.  
03-06-2011
Association of Genetic Loci With Glucose Levels in Childhood and Adolescence A Meta-Analysis of Over 6,000 Children
Barker A, Sharp SJ, Timpson NJ, Bouatia-Naji N, Warrington NM, Kanoni S, Beilin LJ, Brage S et al.
Diabetes, American Diabetes Association vol. 60 (6), 1805-1812.  
21-05-2011
Identification of an imprinted master trans regulator at the KLF14 locus related to multiple metabolic phenotypes
Small KS, Hedman ÅK, Grundberg E, Nica AC, Thorleifsson G, Kong A, Thorsteindottir U, Shin S-Y et al.
Nature Genetics, Springer Nature vol. 43 (6), 561-564.  
15-05-2011
Associations of Common Genetic Variants With Age-Related Changes in Fasting and Postload Glucose Evidence From 18 Years of Follow-Up of the Whitehall II Cohort
Jensen AC, Barker A, Kumari M, Brunner EJ, Kivimäki M, Hingorani AD, Wareham NJ, Tabák AG et al.
Diabetes, American Diabetes Association vol. 60 (5), 1617-1623.  
23-04-2011
An amino acid profile to predict diabetes?
Langenberg C, Savage DB
Nature Medicine, Springer Nature vol. 17 (4), 418-420.  
01-04-2011
Erratum: Corrigendum: Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C et al.
Nature Genetics, Springer Nature vol. 43 (4), 388-388.  
29-03-2011
Common variants at 10 genomic loci influence hemoglobin A1C levels via glycemic and nonglycemic pathways (Diabetes (2010) 59, (3229-3239))
Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C et al.
Diabetes vol. 60 (3) 
01-03-2011
Genome-Wide Association Analysis Identifies Variants Associated with Nonalcoholic Fatty Liver Disease That Have Distinct Effects on Metabolic Traits
Speliotes EK, Yerges-Armstrong LM, Wu J, Hernaez R, Kim LJ, Palmer CD, Gudnason V, Eiriksdottir G et al.
Plos Genetics, Public Library of Science (Plos) vol. 7 (3) 
01-03-2011
Mendelian Randomization Studies Do Not Support a Role for Raised Circulating Triglyceride Levels Influencing Type 2 Diabetes, Glucose Levels, or Insulin Resistance
De Silva NMG, Freathy RM, Palmer TM, Donnelly LA, Luan J, Gaunt T, Langenberg C, Weedon MN et al.
Diabetes, American Diabetes Association vol. 60 (3), 1008-1018.  
21-02-2011
Erratum
Diabetes Care, American Diabetes Association vol. 34 (3), 785-786.  
17-02-2011
Genetic predisposition to obesity leads to increased risk of type 2 diabetes
Li S, Zhao JH, Luan J, Langenberg C, Luben RN, Khaw KT, Wareham NJ, Loos RJF
Diabetologia, Springer Nature vol. 54 (4), 776-782.  
26-01-2011
Design and Cohort Description of the InterAct Project: An Examination of the Interaction of Genetic and Lifestyle Factors on the Incidence of Type 2 Diabetes in the EPIC Study
Langenberg C, Wareham NJ
 
01-01-2011
Are population-based carriers of a mutation associated with cystic fibrosis patients more likely to have diabetes?
Adler A, Langenberg C, Sims M, Wareham NJ
 
01-01-2011
Long-term risk of type 2 diabetes and measures of overall and regional obesity: the European InterAct study
Langenberg C, Sharp SJ, Wareham NJ
 
01-01-2011
Genome-wide joint meta-analysis of SNP by BMI interaction on fasting insulin: a MAGIC study
Scott RA, Manning AK, Hivert M-F, Bouatia-Naji N, Grimsby J, Liu C-T, Chen H, Bielak LF et al.
 
01-01-2011
The association and causal inference between circulating 25-hydroxy vitamin D concentration and the risk of type 2 diabetes
Forouhi NG, Ye Z, Rickard AP, Khaw K-T, Luben R, Langenberg C, Wareham NJ
 
01-01-2011
Large-scale replication using Metabochip array identifies additional genetic loci influencing glycaemic traits
Prokopenko I, Lagou V, Scott RA, Wheeler E, Welch R, Luan J, Maegi R, Teslovich TM et al.
 
01-01-2011

2010

Differential White Blood Cell Count and Type 2 Diabetes: Systematic Review and Meta-Analysis of Cross-Sectional and Prospective Studies
Gkrania-Klotsas E, Ye Z, Cooper AJ, Sharp SJ, Luben R, Biggs ML, Chen L-K, Gokulakrishnan K et al.
Plos One, Public Library of Science (Plos) vol. 5 (10) 
18-10-2010
Common Variants at 10 Genomic Loci Influence Hemoglobin A1C Levels via Glycemic and Nonglycemic Pathways
Soranzo N, Sanna S, Wheeler E, Gieger C, Radke D, Dupuis J, Bouatia-Naji N, Langenberg C et al.
Diabetes, American Diabetes Association vol. 59 (12), 3229-3239.  
21-09-2010
Interactions of Dietary Whole-Grain Intake With Fasting Glucose– and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies
Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert M-F, Ngwa J, van Rooij FJA, Sonestedt E et al.
Diabetes Care, American Diabetes Association vol. 33 (12), 2684-2691.  
06-08-2010
Biological, clinical and population relevance of 95 loci for blood lipids
Teslovich TM, Musunuru K, Smith AV, Edmondson AC, Stylianou IM, Koseki M, Pirruccello JP, Ripatti S et al.
Nature, Springer Nature vol. 466 (7307), 707-713.  
01-08-2010
Twelve type 2 diabetes susceptibility loci identified through large-scale association analysis
Voight BF, Scott LJ, Steinthorsdottir V, Morris AP, Dina C, Welch RP, Zeggini E, Huth C et al.
Nature Genetics, Springer Nature vol. 42 (7), 579-589.  
27-06-2010
Genetic Markers of Adult Obesity Risk Are Associated with Greater Early Infancy Weight Gain and Growth
Elks CE, Loos RJF, Sharp SJ, Langenberg C, Ring SM, Timpson NJ, Ness AR, Smith GD et al.
Plos Medicine, Public Library of Science (Plos) vol. 7 (5) 
25-05-2010
Erratum: New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al.
Nature Genetics, Springer Nature vol. 42 (5), 464-464.  
01-05-2010
MTNR1B rs10830963 is associated with fasting plasma glucose, HbA1Cand impaired beta-cell function in Chinese Hans from Shanghai
Liu C, Wu Y, Li H, Qi Q, Langenberg C, Loos RJ, Lin X
Bmc Medical Genomics, Springer Nature vol. 11 (1) 
14-04-2010
Analysis of TBC1D4 in patients with severe insulin resistance
Dash S, Langenberg C, Fawcett KA, Semple RK, Romeo S, Sharp S, Sano H, Lienhard GE et al.
Diabetologia, Springer Nature vol. 53 (6), 1239-1242.  
27-03-2010
O10 Une méta-analyse GWA de la glycémie après 2 h d’HGPO révèle que GIPR est associé avec la sécrétion de l’insuline en réponse au glucose et que ADCY5 est un nouveau gène de susceptibilité au diabète de type 2
Bouatia-Naji N, Saxena R, Hivert MF, Langenberg C, Tanaka T, Pankow J, Vollenweider P, Lyssenko V et al.
Diabetes & Metabolism, Elsevier vol. 36 
01-03-2010
Detailed Physiologic Characterization Reveals Diverse Mechanisms for Novel Genetic Loci Regulating Glucose and Insulin Metabolism in Humans
Ingelsson E, Langenberg C, Hivert M-F, Prokopenko I, Lyssenko V, Dupuis J, Mägi R, Sharp S et al.
Diabetes, American Diabetes Association vol. 59 (5), 1266-1275.  
25-02-2010
New genetic loci implicated in fasting glucose homeostasis and their impact on type 2 diabetes risk
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al.
Nature Genetics, Springer Nature vol. 42 (2), 105-116.  
17-01-2010
Genetic variation in GIPR influences the glucose and insulin responses to an oral glucose challenge
Saxena R, Hivert M-F, Langenberg C, Tanaka T, Pankow JS, Vollenweider P, Lyssenko V, Bouatia-Naji N et al.
Nature Genetics, Springer Nature vol. 42 (2), 142-148.  
17-01-2010
Interactions of Dietary Whole-Grain Intake With Fasting Glucose- and Insulin-Related Genetic Loci in Individuals of European Descent A meta-analysis of 14 cohort studies
Nettleton JA, McKeown NM, Kanoni S, Lemaitre RN, Hivert M-F, Ngwa J, van Rooij FJA, Sonestedt E et al.
Diabetes Care vol. 33 (12), 2684-2691.  
01-01-2010
Age-dependent genetic effects on post-load glucose during 18 years of follow-up of the Whitehall II Cohort
Langenberg C, Jensen AC, Barker A, Brunner EJ, Hingorani AD, Kumari M, Kivimaeki M, Wareham NJ et al.
 
01-01-2010

2009

Parental origin of sequence variants associated with complex diseases
Kong A, Steinthorsdottir V, Masson G, Thorleifsson G, Sulem P, Besenbacher S, Jonasdottir A, Sigurdsson A et al.
Nature, Springer Nature vol. 462 (7275), 868-874.  
01-12-2009
A Genome-Wide Association Study Reveals Variants in ARL15 that Influence Adiponectin Levels
Richards JB, Waterworth D, O'Rahilly S, Hivert M-F, Loos RJF, Perry JRB, Tanaka T, Timpson NJ et al.
Plos Genetics, Public Library of Science (Plos) vol. 5 (12) 
01-12-2009
Genetic evidence that raised sex hormone binding globulin (SHBG) levels reduce the risk of type 2 diabetes
Perry JRB, Weedon MN, Langenberg C, Jackson AU, Lyssenko V, Sparsø T, Thorleifsson G, Grallert H et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 19 (3), 535-544.  
18-11-2009
Common Genetic Determinants of Glucose Homeostasis in Healthy Children The European Youth Heart Study
Kelliny C, Ekelund U, Andersen LB, Brage S, Loos RJF, Wareham NJ, Langenberg C
Diabetes, American Diabetes Association vol. 58 (12), 2939-2945.  
09-09-2009
Underlying Genetic Models of Inheritance in Established Type 2 Diabetes Associations
Salanti G, Southam L, Altshuler D, Ardlie K, Barroso I, Boehnke M, Cornelis MC, Frayling TM et al.
American Journal of Epidemiology, Oxford University Press (Oup) vol. 170 (5), 537-545.  
14-07-2009
A truncation mutation in TBC1D4 in a family with acanthosis nigricans and postprandial hyperinsulinemia
Dash S, Sano H, Rochford JJ, Semple RK, Yeo G, Hyden CSS, Soos MA, Clark J et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 106 (23), 9350-9355.  
09-06-2009
Common genetic variation in the melatonin receptor 1B gene (MTNR1B) is associated with decreased early-phase insulin response
Langenberg C, Pascoe L, Mari A, Tura A, Laakso M, Frayling TM, Barroso I, Loos RJF et al.
Diabetologia, Springer Nature vol. 52 (8) 
20-05-2009
Mendelian Randomization Studies of the Role of Biomarkers in Type 2 Diabetes
Perry J, Zeggini E, Scott L, Saxena R, Voight B, Ferrucci L, Maggio M, Paolisso G et al.
 
01-01-2009
Childhood Phenotypes Related to Adult Obesity: The Application of Genetic Risk Variants
Elks C, Loos RJF, Davey-Smith G, Dunger D, Wareham N, Ong K, Sharp S, Langenberg C et al.
 
01-01-2009
Novel Genetic Loci Implicated in Fasting Glucose Homeostasis and Their Impact on Related Metabolic Traits
Dupuis J, Langenberg C, Prokopenko I, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al.
 
01-01-2009
A Large Genome-wide Association Study of Glycated Hemoglobin Identifies Ten Common Variants not Mediated Through BMI
Wheeler E, Soranzo N, Sanna S, Gieger C, Radke D, Dupuis J, Stolerman E, Bouatia-Naji N et al.
 
01-01-2009
Genome-wide meta-analysis identifies novel genetic loci associated with OGTT-induced post-challenge glucose
Langenberg C, Saxena R, Hivert M-F, Tanaka T, Pankow JS, Lyssenko V, Boutia-Naji N, Kao WHL et al.
 
01-01-2009
Novel genetic loci implicated in fasting glucose homeostasis and their impact on related metabolic traits
Prokopenko I, Dupuis J, Langenberg C, Saxena R, Soranzo N, Jackson AU, Wheeler E, Glazer NL et al.
 
01-01-2009
Meta-Analyses of Genome-Wide Association Studies for 2-Hour Glucose Levels during an Oral Glucose Tolerance Test Identify Novel Genetic Loci
Saxena R, Hivert M-F, Dupuis J, Langenberg C, Kao WL, Tanaka T, Jackson AU, Pankow JS et al.
 
01-01-2009
Variants in the DGKB Gene Influence Fasting Glucose Levels in Populations of European and East Asian Descent
Prokopenko I, Hottenga JJ, Aulchenko YS, Thorleifsson G, Dupuis J, Florez JC, Go MJ, Jackson AU et al.
 
01-01-2009

2008

Variants in MTNR1B influence fasting glucose levels
Prokopenko I, Langenberg C, Florez JC, Saxena R, Soranzo N, Thorleifsson G, Loos RJF, Manning AK et al.
Nature Genetics, Springer Nature vol. 41 (1), 77-81.  
07-12-2008
Meta-analysis of genome-wide association data and large-scale replication identifies additional susceptibility loci for type 2 diabetes
Zeggini E, Scott LJ, Saxena R, Voight BF, Marchini JL, Hu T, de Bakker PI, Abecasis GR et al.
Nature Genetics, Springer Nature vol. 40 (5), 638-645.  
30-03-2008
Prevalence of Angina in Women Versus Men
Hemingway H, Langenberg C, Damant J, Frost C, Pyörälä K, Barrett-Connor E
Circulation, Wolters Kluwer vol. 117 (12), 1526-1536.  
17-03-2008
Usefulness of Microalbuminuria Versus the Metabolic Syndrome as a Predictor of Cardiovascular Disease in Women and Men >40 Years of Age (from the Rancho Bernardo Study)
Jassal SK, Langenberg C, von Mühlen D, Bergstrom J, Barrett-Connor E
The American Journal of Cardiology, Elsevier vol. 101 (9), 1275-1280.  
07-03-2008
Pre-morbid intelligence, the metabolic syndrome and mortality: the Vietnam Experience Study
Batty GD, Gale CR, Mortensen LH, Langenberg C, Shipley MJ, Deary IJ
Diabetologia, Springer Nature vol. 51 (3), 436-443.  
18-01-2008
Novel type 2 diabetes susceptibility loci and measures of glycaemic control in a population based study of healthy children
Langenberg C, Loos RJF, Brage S, Sardinha LB, Andersen LB, Ekelund U, Wareham NJ
 
01-01-2008

2007

Diabetes and Coronary Heart Disease in Filipino-American Women Role of growth and life-course socioeconomic factors
Langenberg C, Araneta MRG, Bergstrom J, Marmot M, Barrett-Connor E
Diabetes Care, American Diabetes Association vol. 30 (3), 535-541.  
01-03-2007
Life course body size and lipid levels at 53 years in a British birth cohort
Skidmore PML, Hardy RJ, Kuh DJ, Langenberg C, Wadsworth MEJ
Journal of Epidemiology & Community Health, Bmj vol. 61 (3) 
26-02-2007

2006

Household Wealth and the Metabolic Syndrome in the Whitehall II Study
Perel P, Langenberg C, Ferrie J, Moser K, Brunner E, Marmot M
Diabetes Care, American Diabetes Association vol. 29 (12), 2694-2700.  
01-12-2006
Adult height and lung function as markers of life course exposures: Associations with risk factors and cause-specific mortality
Batty GD, Gunnell D, Langenberg C, Smith GD, Marmot MG, Shipley MJ
European Journal of Epidemiology, Springer Nature vol. 21 (11), 795-801.  
01-11-2006
Social Circumstances and Education: Life Course Origins of Social Inequalities in Metabolic Risk in a Prospective National Birth Cohort
Langenberg C, Kuh D, Wadsworth MEJ, Brunner E, Hardy R
American Journal of Public Health, American Public Health Association vol. 96 (12), 2216-2221.  
31-10-2006
Association of Adiponectin with Coronary Heart Disease and Mortality
Laughlin GA, Barrett-Connor E, May S, Langenberg C
American Journal of Epidemiology, Oxford University Press (Oup) vol. 165 (2), 164-174.  
27-09-2006
Birth weight, components of height and coronary heart disease: evidence from the Whitehall II study
Ferrie JE, Langenberg C, Shipley MJ, Marmot MG
International Journal of Epidemiology, Oxford University Press (Oup) vol. 35 (6), 1532-1542.  
24-08-2006
Cardiovascular Death and the Metabolic Syndrome Role of adiposity-signaling hormones and inflammatory markers
Langenberg C, Bergstrom J, Scheidt-Nave C, Pfeilschifter J, Barrett-Connor E
Diabetes Care, American Diabetes Association vol. 29 (6), 1363-1369.  
01-06-2006
Ghrelin and Bone: Is There an Association in Older Adults?: The Rancho Bernardo Study*
Weiss LA, Langenberg C, Barrett‐Connor E
Journal of Bone and Mineral Research, Oxford University Press (Oup) vol. 21 (5), 752-757.  
01-05-2006
Sex differences in angina pectoris: meta-analysis of international variations in 53 studies in 23 countries
Langenberg C, Barrett-Connor E, Damant J, Hemingway H
European Journal of Preventive Cardiology, Oxford University Press (Oup) vol. 13 (Supplement 1) 
01-05-2006
Metabolic syndrome improves the prediction of coronary heart disease mortality in diabetes
Langenberg C, Bergstrom J, Von Mühlen D, Barrett-Connor E
 
01-01-2006
Aortic and coronary calcium in diabetic and nondiabetic men and women in the Multi-Ethnic Study of Atherosclerosis (MESA)
Langenberg C, Allison M, Wong N, Detrano R, Shea S, Carr J, Criqui M
 
01-01-2006
Albuminuria improves prediction of cardiovascular disease mortality in older women with or without metabolic syndrome
Jassal SK, Langenberg C, Bergstrom J, von Muhlen D, Barrett-Connor E
 
01-01-2006
Novel risk factors do not improve prediction of cardiovascular mortality: Evidence from the Rancho Bernardo Study
Bergstrom J, Langenberg C, von Muhlen D, Barrett-Connor E
 
01-01-2006

2005

Adult height in relation to mortality from 14 cancer sites in men in London (UK): evidence from the original Whitehall study
Batty GD, Shipley MJ, Langenberg C, Marmot MG, Smith GD
Annals of Oncology, Elsevier vol. 17 (1), 157-166.  
25-10-2005
Ghrelin, Adiponectin, and Leptin Do Not Predict Long-term Changes in Weight and Body Mass Index in Older Adults: Longitudinal Analysis of the Rancho Bernardo Cohort
Langenberg C, Bergstrom J, Laughlin GA, Barrett-Connor E
American Journal of Epidemiology, Oxford University Press (Oup) vol. 162 (12), 1189-1197.  
19-10-2005
Ghrelin and the Metabolic Syndrome in Older Adults
Langenberg C, Bergstrom J, Laughlin GA, Barrett-Connor E
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society vol. 90 (12), 6448-6453.  
04-10-2005
211-S: Household Wealth and the Metabolic Syndrome in the Whitehall II Cohort
Perel P, Langenberg C, Ferrie J, Moser K, Brunner E, Marmot M
American Journal of Epidemiology, Oxford University Press (Oup) vol. 161 (Supplement_1), s53-s53.  
27-06-2005
Department of Error
The Lancet, Elsevier vol. 365 (9471) 
01-05-2005
Influence of short stature on the change in pulse pressure, systolic and diastolic blood pressure from age 36 to 53 years: an analysis using multilevel models
Langenberg C, Hardy R, Breeze E, Kuh D, Wadsworth MEJ
International Journal of Epidemiology, Oxford University Press (Oup) vol. 34 (4), 905-913.  
15-04-2005
Adult Socioeconomic Position and the Association Between Height and Coronary Heart Disease Mortality: Findings From 33 Years of Follow-Up in the Whitehall Study
Langenberg C, Shipley MJ, Batty GD, Marmot MG
American Journal of Public Health, American Public Health Association vol. 95 (4), 628-632.  
01-04-2005
Cardiovascular risk at age 53 years in relation to the menopause transition and use of hormone replacement therapy: a prospective British birth cohort study
Kuh D, Langenberg C, Hardy R, Kok H, Cooper R, Butterworth S, Wadsworth MEJ
Bjog An International Journal of Obstetrics & Gynaecology, Wiley vol. 112 (4), 476-485.  
19-02-2005
Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort (vol 362, pg 1178, 2003)
Hardy R, Kuh D, Langenberg C, Wadsworth MEJ
Lancet vol. 365 (9471), 1620-1620.  
01-01-2005
Cardiovascular death and the metabolic syndrome: Role of inflammatory cytokines and adiposity signaling hormones
Langenberg C, Bergstrom J, Barrett-Connor E
 
01-01-2005
Hormonal signals of weight homeostasis and 18-year weight change in older adults: Longitudinal analysis of the Rancho Bernardo cohort
Langenberg C, Bergstrom J, Laughlin GA, Barrett-Connor E
 
01-01-2005

2004

Birthweight, childhood growth, and blood pressure at 43 years in a British birth cohort
Hardy R, Wadsworth MEJ, Langenberg C, Kuh D
International Journal of Epidemiology, Oxford University Press (Oup) vol. 33 (1), 121-129.  
01-02-2004
Birth Weight and Lipids in a National Birth Cohort Study
Skidmore PML, Hardy RJ, Kuh DJ, Langenberg C, Wadsworth MEJ
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 24 (3), 588-594.  
08-01-2004

2003

Commentary: The association between height growth and cholesterol levels during puberty: implications for adult health
Hardy R, Langenberg C
International Journal of Epidemiology, Oxford University Press (Oup) vol. 32 (6), 1110-1111.  
01-12-2003
The life course prospective design: an example of benefits and problems associated with study longevity
Wadsworth MEJ, Butterworth SL, Hardy RJ, Kuh DJ, Richards M, Langenberg C, Hilder WS, Connor M
Social Science & Medicine, Elsevier vol. 57 (11), 2193-2205.  
01-12-2003
Birthweight, childhood social class, and change in adult blood pressure in the 1946 British birth cohort
Hardy R, Kuh D, Langenberg C, Wadsworth ME
The Lancet, Elsevier vol. 362 (9391), 1178-1183.  
01-10-2003
Central and total obesity in middle aged men and women in relation to lifetime socioeconomic status: evidence from a national birth cohort
Langenberg C, Hardy R, Kuh D, Brunner E, Wadsworth M
Journal of Epidemiology & Community Health, Bmj vol. 57 (10) 
01-10-2003
Commentary: Disentangling the association between short height and cardiovascular risk—genes or environment?
Langenberg C, Marmot M
International Journal of Epidemiology, Oxford University Press (Oup) vol. 32 (4), 614-616.  
01-08-2003
Influence of height, leg and trunk length on pulse pressure, systolic and diastolic blood pressure
Langenberg C, Hardy R, Kuh D, Wadsworth ME
Journal of Hypertension, Wolters Kluwer vol. 21 (3), 537-543.  
01-03-2003
Human organic anion transporter 3 (hOAT3) in human adrenocortical cells transports cortisol
Asif AR, Grunewald RW, Langenberg C, Metten M, Jarry H, Müller GA, Burckhardt G, Hagos Y
 
01-01-2003

2002

Mortality in adults aged 26-54 years related to socioeconomic conditions in childhood and adulthood: post war birth cohort study
Kuh D, Hardy R, Langenberg C, Richards M, Wadsworth MEJ
The Bmj, Bmj vol. 325 (7372) 
09-11-2002

2001

EbM-courses for hospital and practise settings - Current models in Germany
Pritsche L, Donner-Banzhoff N, Druck G, Kunz R, Langenberg C, Lelgemann M, Pientka L, Von Maxen A et al.
Zeitschrift Fur Arztliche Fortbildung Und Qualitatssicherung vol. 95 (4), 297-298.  
01-12-2001
Evidence-based medicine: What kind of competencies should medical education provide?
Helou A, Perleth M, Lühmann D, Langenberg C, Busse R
 
01-01-2001

1999

Final and causal foundations of medical practice--two achievements of evidence-based medicine.
Raspe H, Langenberg C
Zeitschrift FüR Evidenz Fortbildung Und QualitäT Im Gesundheitswesen vol. 93 (4) 
01-06-1999

Machine learning-guided deconvolution of plasma protein levels
Pietzner M, Beuchel C, Demircan K, Anton JH, Zeng W, Römisch-Margl W, Yasmeen S, Uluvar B et al.
In Medrxiv 
A genetic map of human metabolism across the allele frequency spectrum
Zoodsma M, Beuchel C, Yasmeen S, Kohleick L, Nepal A, Koprulu M, Kronenberg F, Mayr M et al.
In Medrxiv 
Leveraging Large-Scale Biobanks for Therapeutic Target Discovery
Ferolito BR, Dashti H, Giambartolomei C, Peloso GM, Golden DJ, Gravel-Pucillo K, Rasooly D, Horimoto AR et al.
In Medrxiv 
Exome sequencing and analysis of 44,028 British South Asians enriched for high autozygosity
Kim HI, DeBoever C, Walter K, Kalantzis G, Li C, Mozaffari SV, Kundu K, Jacobs BM et al.
In Medrxiv 
Nanoparticle enriched mass spectrometry proteomics in British South Asians identifies novel variant-protein-disease mechanisms
Pietzner M, Williamson A, Hunt KA, Koprulu M, Kohleick L, Demircan K, Team GHR, Finer S et al.
In Medrxiv 
Glycaemic and bodyweight effects of GIPR coding variation reflect differences in both surface expression and intrinsic functional impairment
Manchanda Y, Desoki R, Gardner EJ, Perry JR, Wainscott DB, Stutsman C, Langenberg C, Coghlan M et al.
In Medrxiv 
A genomic-led strategy to anticipate drug safety effects
Ferolito BR, Horimoto AR, Gravel-Pucillo K, Golden DJ, Dashti H, Giambartolomei C, Rasooly D, Matty R et al.
In Medrxiv 
An ancestry-enriched HNF4A variant and GP2 reveal distinct mechanisms of type 2 diabetes in exome-wide study of 13,674 cases and 41,024 controls
Hodgson S, Bui V, Bigossi M, Bigossi M, Bigossi M, Huerta-Chagoya A, Hu S, Blee AM et al.
In Medrxiv 
Proteomic and clinical impact of human knockouts in British South Asians
Zanini JC, Pietzner M, Koprulu M, Zoodsma M, Williamson A, Hunt KA, Manolias A, Walter K et al.
In Medrxiv 
GWAS metanalysis of atrial fibrillation reveals significant sex-related heterogeneity effects of the PITX2 and CFL2 loci
Cárcel-Márquez J, Boldo P, Llucià-Carol L, Muiño E, Gallego-Fabrega C, Cullell N, Lledós M, Martín-Campos JM et al.
In Research Square 
KidneyGenAfrica: A multi-cohort Genome-wide association study and polygenic prediction of kidney function in 110,000 continental and diasporan Africans
Fatumo S, Kamiza A, Chikowore T, Chen G, Ojewunmi O, Machipisa T, Zhou F, Mayanja R et al.
In Research Square 
Quantifying the multi-tissue response to glucose ingestion in humans by plasma proteomics
Uluvar B, Williamson A, Kolnes KJ, Jeppesen PB, Kolnes AJ, Koprulu M, Zoodsma M, Beuchel C et al.
Diabetologia, Springer 
Estimating excess 1- year mortality from COVID-19 according to underlying conditions and age in England: a rapid analysis using NHS health records in 3.8 million adults
Banerjee A, Pasea L, Harris S, Gonzalez-Izquierdo A, Torralbo A, Shallcross L, Noursadeghi M, Pillay D et al.
In Medrxiv 
rs641738C>T near MBOAT7 is positively associated with liver fat, ALT, and histological severity of NAFLD: a meta-analysis
Teo K, Abeysekera KWM, Adams L, Aigner E, Banales JM, Banerjee R, Basu P, Berg T et al.
In Medrxiv 
A Saturated Map of Common Genetic Variants Associated with Human Height from 5.4 Million Individuals of Diverse Ancestries
Yengo L, Vedantam S, Marouli E, Sidorenko J, Bartell E, Sakaue S, Graff M, Eliasen AU et al.
In Biorxiv 
Trans-ancestry genetic study of type 2 diabetes highlights the power of diverse populations for discovery and translation
Mahajan A, Spracklen CN, Zhang W, Ng MC, Petty LE, Kitajima H, Yu GZ, Rüeger S et al.
In Medrxiv 
Protein-Coding Variants Implicate Novel Genes Related to Lipid Homeostasis Contributing to Body Fat Distribution
Justice AE, Karaderi T, Highland HM, Young KL, Graff M, Lu Y, Turcot V, Auer PL et al.
In Biorxiv 
Genetic insights into the biological mechanisms governing human ovarian ageing
Ruth KS, Day FR, Hussain J, Martínez-Marchal A, Aiken CE, Azad A, Thompson DJ, Abe H et al.
In Medrxiv 
Implicating genes, pleiotropy and sexual dimorphism at blood lipid loci through multi-ancestry meta-analysis
Kanoni S, Graham SE, Wang Y, Surakka I, Ramdas S, Zhu X, Clarke SL, Bhatti KF et al.
In Medrxiv 
A multi-layer functional genomic analysis to understand noncoding genetic variation in lipids
Ramdas S, Judd J, Graham SE, Kanoni S, Wang Y, Surakka I, Wenz B, Clarke SL et al.
In Biorxiv 
Genome-wide association study provides new insights into the genetic architecture and pathogenesis of heart failure
Shah S, Henry A, Roselli C, Lin H, Sveinbjörnsson G, Fatemifar G, Hedman ÅK, Wilk JB et al.
In Biorxiv 
The Trans-Ancestral Genomic Architecture of Glycaemic Traits
Chen J, Spracklen CN, Marenne G, Varshney A, Corbin LJ, Luan J, Willems S, Wu Y et al.
In Biorxiv 
Genome-wide analysis in over 1 million individuals reveals over 2,000 independent genetic signals for blood pressure
Warren H, Edwards T, Vaez A, Keaton J, Kamali Z, Xie T, Ani A, Evangelou E et al.
In Research Square 
Tissue-Specific Alteration of Metabolic Pathways Influences Glycemic Regulation
Ng NHJ, Willems SM, Fernandez J, Fine RS, Wheeler E, Wessel J, Kitajima H, Marenne G et al.
In Biorxiv 
Genetic analysis of over one million people identifies 535 novel loci for blood pressure
Evangelou E, Warren HR, Mosen-Ansorena D, Mifsud B, Pazoki R, Gao H, Ntritsos G, Dimou N et al.
In Biorxiv 
Refining the accuracy of validated target identification through coding variant fine-mapping in type 2 diabetes
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Genomic analyses for age at menarche identify 389 independent signals and indicate BMI-independent effects of puberty timing on cancer susceptibility
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Novel blood pressure locus and gene discovery using GWAS and expression datasets from blood and the kidney
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Random glucose GWAS in 493,036 individuals provides insights into diabetes pathophysiology, complications and treatment stratification
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Maternal and fetal genetic effects on birth weight and their relevance to cardio-metabolic risk factors
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Fine-mapping of an expanded set of type 2 diabetes loci to single-variant resolution using high-density imputation and islet-specific epigenome maps
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STROBE-MR: Guidelines for strengthening the reporting of Mendelian randomization studies
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New genetic signals for lung function highlight pathways and pleiotropy, and chronic obstructive pulmonary disease associations across multiple ancestries
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SNPs associated with HHIP expression have differential effects on lung function in males and females
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Phenome-wide association analysis of LDL-cholesterol lowering genetic variants in PCSK9
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Genome-wide association analysis and Mendelian randomization proteomics identify drug targets for heart failure
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Multi-ancestry genome-wide association study improves resolution of genes, pathways and pleiotropy for lung function and chronic obstructive pulmonary disease
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Performance of polygenic risk scores in screening, prediction, and risk stratification
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From genome to phenome via the proteome: broad capture, antibody-based proteomics to explore disease mechanisms
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Causal effects of maternal circulating amino acids on offspring birthweight: a Mendelian randomisation study
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Damaging missense variants in IGF1R implicate a role for IGF-1 resistance in the aetiology of type 2 diabetes
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The relationship of maternal gestational mass spectrometry-derived metabolites with offspring congenital heart disease: results from multivariable and Mendelian randomization analyses
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Estimating the Population Benefits of Blood Pressure Lowering: A Wide-Angled Mendelian Randomization Study in UK Biobank
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Elucidating the genetic architecture underlying IGF1 levels and its impact on genomic instability and cancer risk
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Regional fat depot masses are influenced by protein-coding gene variants
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Development and validation of total and regional body composition prediction equations from anthropometry and single frequency segmental bioelectrical impedance with DEXA
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Genetic Disruption of Serine Biosynthesis is a Key Driver of Macular Telangiectasia Type 2 Etiology and Progression
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Genome-wide scan and fine-mapping of rare nonsynonymous associations implicates intracellular lipolysis genes in fat distribution and cardio-metabolic risk
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Characterization of missing values in untargeted MS-based metabolomics data and evaluation of missing data handling strategies
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Circulating selenium and prostate cancer risk: a Mendelian randomization analysis
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A comprehensive reanalysis of publicly available GWAS datasets reveals an X chromosome rare regulatory variant associated with high risk for type 2 diabetes
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Lowering of circulating sclerostin may increase risk of atherosclerosis and its risk factors: evidence from a genome-wide association meta-analysis followed by Mendelian randomization
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An atlas of genetic scores to predict multi-omic traits
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Acute caloric restriction acts on the plasma proteome and reveals Apolipoprotein C1 as a signal of nutritional state and metabolic disease
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ELF5 is a respiratory epithelial cell-specific risk gene for severe COVID-19
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Circulating proteins to predict adverse COVID-19 outcomes
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Identification of rare loss of function variation regulating body fat distribution
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Mapping genetic determinants of 184 circulating proteins in 26,494 individuals to connect proteins and diseases
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Mendelian randomisation identifies alternative splicing of the FAS death receptor as a mediator of severe COVID-19
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Cross-platform proteomics to advance genetic prioritisation strategies
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The systematic use of metabolomic epidemiology, biobanks, and electronic medical records for precision medicine initiatives in asthma: findings suggest new guidelines to optimize treatment
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Identifying high-risk groups for change in weight and body mass index: population cohort of 11 million measurements in 2.3 million adults
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Actionable druggable genome-wide Mendelian randomization identifies repurposing opportunities for COVID-19
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A Neanderthal OAS1 isoform Protects Against COVID-19 Susceptibility and Severity: Results from Mendelian Randomization and Case-Control Studies
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Genetic architecture of host proteins interacting with SARS-CoV-2
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Genome-wide meta-analysis of muscle weakness identifies 15 susceptibility loci in older men and women
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Weight change and the incidence of cardiovascular diseases in adults with normal weight, overweight and obesity without chronic diseases; emulating trials using electronic health records
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Transcriptional, epigenetic and metabolic signatures in cardiometabolic syndrome defined by extreme phenotypes
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Clinical classifiers of COVID-19 infection from novel ultra-high-throughput proteomics
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High-throughput multivariable Mendelian randomization analysis prioritizes apolipoprotein B as key lipid risk factor for coronary artery disease
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Cross-platform genetic discovery of small molecule products of metabolism and application to clinical outcomes
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Diabetes mellitus, glycemic traits, and cerebrovascular disease: a Mendelian randomization study
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Genomic analysis of diet composition finds novel loci and associations with health and lifestyle
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Circulating metabolites modulated by diet are causally associated with depression
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Genetic associations and architecture of asthma-chronic obstructive pulmonary disease overlap
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Genetic risk score for intracranial aneurysms to predict aneurysmal subarachnoid hemorrhage and identify associations with patient characteristics
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Genome-wide pleiotropy analysis identifies novel blood pressure variants and improves its polygenic risk scores
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Identification of 370 genetic loci for age at first sex and birth linked to externalising behaviour
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Medical history predicts phenome-wide disease onset and enables the rapid response to emerging health threats
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Unraveling Neuro-Proteogenomic Landscape and Therapeutic Implications for Human Behaviors and Psychiatric Disorders
Repetto L, Chen J, Yang Z, Zhai R, Timmers PRHJ, Li T, Twait EL, May-Wilson S et al.
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Multi-ancestry genome-wide study in >2.5 million individuals reveals heterogeneity in mechanistic pathways of type 2 diabetes and complications
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COL6A3-derived endotrophin mediates the effect of obesity on coronary artery disease: an integrative proteogenomics analysis
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Identifying therapeutic targets for cancer: 2,094 circulating proteins and risk of nine cancers
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Complex patterns of multimorbidity associated with severe COVID-19 and Long COVID
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Proteomic prediction of common and rare diseases
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Proteomic analysis of 92 circulating proteins and their effects in cardiometabolic diseases
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Physical activity and sedentary behavior; mechanistic insights and role in disease prevention
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Identifying proteomic risk factors for overall, aggressive and early onset prostate cancer using Mendelian randomization and tumor spatial transcriptomics
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Mapping the aetiological foundations of the heart failure spectrum using human genetics
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Genetic architecture of routinely acquired blood tests in a UK cohort of South Asian ancestry reveals ancestry-specific causal variants
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Similar and different: systematic investigation of proteogenomic variation between sexes and its relevance for human diseases
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The performance of AlphaMissense to identify genes causing disease
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Partitioned polygenic scores highlight role of beta-cell function and unfavourable fat distribution patterns in young onset type 2 diabetes in south Asians
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A predictive atlas of disease onset from retinal fundus photographs
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Large-scale Mendelian randomization identifies novel pathways as therapeutic targets for heart failure with reduced ejection fraction and with preserved ejection fraction
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Damaging mutations in LXRα uncouple lipogenesis from hepatotoxicity and implicate hepatic cholesterol sensing in human liver health
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Transcriptome- and proteome-wide Mendelian randomization to prioritize therapeutic targets for coronary heart disease
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