Dr Carles Gaston-Massuet
Senior Lecturer in Endocrine Genetics
Center of Enodcrinology, William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Endocrinology, Hypothalamus-pituitary axis, genetics, development, tumour biology, endocrine system
Interests
Genetics and molecular mechanisms underlying the hypothalmo-pituitary axis development and its link to disease from endocrine deficiencies to tumorigenesis.Publications
2025
Dlk1 is a novel adrenocortical stem/progenitor cell marker that predicts malignancy in adrenocortical carcinomaMariniello K, Pittaway JFH, Altieri B, Borges KS, Hadjidemetriou I, Ribeiro C, Ruiz‐Babot G, Tourigny DS et al.
Cancer Communications, Wiley vol. 45 (6), 663-668.
04-03-2025
2023
Correction: RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomasGarcia-Rendueles AR, Chenlo M, Oroz-Gonjar F, Solomou A, Mistry A, Barry S, Gaston-Massuet C, Garcia-Lavandeira M et al.
Oncogene, Springer Nature vol. 42 (49), 3655-3656.
06-11-2023
Imprinted Dlk1 dosage as a size determinant of the mammalian pituitary glandScagliotti V, Vignola ML, Willis T, Howard M, Marinelli E, Gaston-Massuet C, Andoniadou C, Charalambous M
Elife, Elife vol. 12
17-08-2023
Dual mechanism underlying failure of neural tube closure in the Zic2 mutant mouse.Escuin S, Rose Raza-Knight S, Savery D, Gaston-Massuet C, Galea GL, Greene NDE, Copp AJ
Disease Models & Mechanisms vol. 16 (3)
01-03-2023
2022
Phosphorylation of β-catenin at Serine552 correlates with invasion and recurrence of non-functioning pituitary neuroendocrine tumoursRai A, Yelamanchi SD, Radotra BD, Gupta SK, Mukherjee KK, Tripathi M, Chhabra R, Ahuja CK et al.
Acta Neuropathologica Communications, Springer Nature vol. 10 (1)
16-09-2022
The imprinted Zdbf2 gene finely tunes control of feeding and growth in neonatesGlaser J, Iranzo J, Borensztein M, Marinucci M, Gualtieri A, Jouhanneau C, Teissandier A, Gaston-Massuet C et al.
Elife, Elife vol. 11
20-01-2022
2021
Hyper-phosphorylation of [beta]-catenin at Serine552 correlates with invasion and predicts recurrence of Non-Functioning Pituitary Tumours (NFPTs)Rai A, Yelamanchi SD, Radotra BD, Gupta SK, Chhabra R, Pandey A, Gaston-Massuet C
BES2021.
18-10-2021
RET signalling provides tumorigenic mechanism and tissue specificity for AIP-related somatotrophinomasGarcia-Rendueles AR, Chenlo M, Oroz-Gonjar F, Solomou A, Mistry A, Barry S, Gaston-Massuet C, Garcia-Lavandeira M et al.
Oncogene, Springer Nature vol. 40 (45), 6354-6368.
29-09-2021
Dysgenesis and Dysfunction of the Pancreas and Pituitary Due to FOXA2 Gene DefectsKaygusuz SB, Ates EA, Vignola ML, Volkan B, Geckinli BB, Turan S
The Journal of Clinical Endocrinology & Metabolism, The Endocrine Society vol. 106 (10), e4142-e4154.
17-05-2021
FOXA2 as a Candidate Gene Responsible for Congenital Panhypopituitarism: A Review of the LiteratureCorreia JC, Corral LG, Kaygusuz SB, Gaston-Massuet C
Journal of The Endocrine Society, The Endocrine Society vol. 5 (Supplement_1), a529-a529.
03-05-2021
WNT3A‐loaded exosomes enable cartilage repairThomas BL, Eldridge SE, Nosrati B, Alvarez M, Thorup A, Nalesso G, Caxaria S, Barawi A et al.
Journal of Extracellular Vesicles, Wiley vol. 10 (7)
01-05-2021
Activating mutations in BRAF disrupt the hypothalamo-pituitary axis leading to hypopituitarism in mice and humansGualtieri A, Kyprianou N, Gregory LC, Vignola ML, Nicholson JG, Tan R, Inoue S-I, Scagliotti V et al.
Nature Communications, Springer Nature vol. 12 (1)
01-04-2021
Novel LZTR1 mutations in subjects with features of Noonan Syndrome and GH insensitivity negatively regulate GH-induced IGF-I production and hyperactivate GH-induced ERK1/2 activation in response to GH in vitroChatterjee S, Bertola DR, Agwu C, Maharaj A, Williams J, Cottrell E, Shapiro L, Andrews A et al.
01-01-2021
2020
Profiling the eicosanoid networks that underlie the anti- and pro-thrombotic effects of aspirinCrescente M, Armstrong PC, Kirkby NS, Edin ML, Chan MV, Lih FB, Jiao J, Maffucci T et al.
The Faseb Journal, Wiley Periodicals Llc
27-06-2020
A Novel SEMA3G Mutation in Two Siblings Affected by Syndromic GnRH DeficiencyOleari R, André V, Lettieri A, Tahir S, Roth L, Paganoni A, Eberini I, Parravicini C et al.
Neuroendocrinology, Karger Publishers vol. 111 (5), 421-441.
04-05-2020
2019
A novel clinical risk score that accurately predicts recurrence of craniopharyngioma - a multicentre cohort studyKyprianou N, Blackburn J, Tan R, Korbonits M, Dattani M, Dutta P, Bhansali A, Rai A et al.
Endocrine Abstracts, Bioscientifica
11-11-2019
Stem Cells, Self-Renewal, and Lineage Commitment in the Endocrine SystemMariniello K, Ruiz-Babot G, McGaugh EC, Nicholson JG, Gualtieri A, Gaston-Massuet C, Nostro MC, Guasti L
Frontiers in Endocrinology, Frontiers vol. 10
08-11-2019
Transcriptomic analyses reveal deregulation of focal adhesion pathway in Aip KO mice and AIP mutation positive human tumoursBollington M, Mistry A, Solomou A, Barry S, Begalli F, Vignola M, Lim CT, Herincs M et al.
Endocrine Abstracts, Bioscientifica
06-11-2019
Investigating the role of AIP in pituitary tumourigenesisMistry A, Solomou A, Vignola ML, Lim CT, Herincs M, Caimari F, Gualtieri A, Rizzoti K
Endocrine Abstracts, Bioscientifica
06-11-2019
Cell-Specific Gene Deletion Reveals the Antithrombotic Function of COX1 and Explains the Vascular COX1/Prostacyclin ParadoxMitchell JA, Shala F, Elghazouli Y, Warner TD, Gaston-Massuet C, Crescente M, Armstrong PC, Herschman HR et al.
Circulation Research, American Heart Association vol. 125 (9), 847-854.
12-09-2019
Pathogenic variants in PLOD3 result in a Stickler syndrome-like connective tissue disorder with vascular complicationsEwans LJ, Colley A, Gaston-Massuet C, Gualtieri A, Cowley MJ, McCabe MJ, Anand D, Lachke SA et al.
Journal of Medical Genetics, Bmj vol. 56 (9)
25-05-2019
Constitutive Activation of β-Catenin in Conventional Dendritic Cells Increases the Insulin Reserve to Ameliorate the Development of Type 2 Diabetes in MiceMacdougall CE, Wood EG, Solomou A, Scagliotti V, Taketo MM, Gaston-Massuet C, Marelli-Berg FM, Charalambous M et al.
Diabetes, American Diabetes Association vol. 68 (7), 1473-1484.
02-05-2019
Impaired EIF2S3 function associated with a novel phenotype of X-linked hypopituitarism with glucose dysregulationGregory LC, Ferreira CB, Young-Baird SK, Williams HJ, Harakalova M, van Haaften G, Rahman SA, Gaston-Massuet C et al.
Ebiomedicine, Elsevier vol. 42, 470-480.
14-03-2019
Tumor microenvironment defines the invasive phenotype of AIP-mutation-positive pituitary tumorsBarry S, Carlsen E, Marques P, Stiles CE, Gadaleta E, Berney DM, Roncaroli F, Chelala C et al.
Oncogene, Springer Nature vol. 38 (27), 5381-5395.
12-03-2019
2018
Rings and Bricks: Expression of Cohesin Components is Dynamic during Development and Adult LifeBettini LR, Graziola F, Fazio G, Grazioli P, Scagliotti V, Pasquini M, Cazzaniga G, Biondi A et al.
International Journal of Molecular Sciences, Mdpi vol. 19 (2)
01-02-2018
Investigating β-catenin signalling in conventional dendritic cells in obesity-induced tissue inflammationMacdougall C, Wood E, Charalambous M, Gaston-Massuet C, Taketo MM, Marelli-Berg F
01-01-2018
2017
The MAPK effector B-Raf is essential for hypothalamic-pituitary axis development and activating mutations in BRAF Cause Congenital hypopituitarismKyprianou N, Gregory L, Vignola ML, Marinelli E, Gualtieri A, Scagliotti V, Davis S, Casado P et al.
Endocrine Abstracts, Bioscientifica
30-10-2017
Novel FOXA2 mutation causes hyperinsulinism, hypopituitarism with craniofacial dysmorphism and endoderm-derived organ abnormalitiesGiri D, Vignola ML, Gualtieri A, Scagliotti V, McNamara P, Peak M, Didi M
Endocrine Abstracts, Bioscientifica
30-10-2017
A comprehensive analysis of the AIP mutation positive pituitary tumour microenvironment: role of stromal cells and the pro-inflammatory cytokine networkBarry S, Solomou A, Vignola L, Collier D, Carlsen E, Gadaleta E, Berney DM, Chelala C et al.
Endocrine Abstracts, Bioscientifica
20-10-2017
Cyclooxygenase-2 is a potential target for the treatment of Adamantinomatous craniopharyngiomaScagliotti V, Gutierrez LP, Gualtieri A, Jimenez F, Kirkby N, Warner T, Gevers E
20-10-2017
Investigating the role of AIP in mouse pituitary adenoma formationSolomou A, Herincs M, Roncaroli F
Endocrine Abstracts, Bioscientifica
20-10-2017
The MAPK effector B-Raf is essential for hypothalamic-pituitary axis development and activating mutations in BRAF cause congenital hypopituitarismKyprianou N, Gregory L, Lillina VM, Besser R, Gualtieri A, Scagliotti V, Gevers E
Endocrine Abstracts, Bioscientifica
20-10-2017
Novel FOXA2 mutation causes Hyperinsulinism, Hypopituitarism with Craniofacial and Endoderm-derived organ abnormalitiesGiri D, Vignola ML, Gualtieri A, Scagliotti V, McNamara P, Peak M, Didi M, Gaston-Massuet C et al.
Human Molecular Genetics, Oxford University Press (Oup) vol. 26 (22), 4315-4326.
24-08-2017
Ephrin-B2 is critical regulator of endocrine organ developmentJimenez FA, Gualtieri A, Scagliotti V
01-07-2017
PLATELET COX-1 KNOCKOUT MOUSE AS A MODEL OF THE EFFECTS OF ASPIRIN IN THE CARDIOVASCULAR SYSTEMCrescente M, Armstrong PC, CHAN MV, Edin ML, Lih FB, Jiao J, Gaston-Massuet C, Cottrell GS et al.
BCS Annual Conference, ‘Cardiology at the Extremes'.
01-06-2017
Ephrin-B2 is required for pituitary developmentJimenez F, Gualtieri A, Scagliotti V
Endocrine Abstracts, Bioscientifica
03-05-2017
Characterization of a Novel Mouse Model of Endothelial Cell Progerin ExpressionRolas L, Barkaway A, Golding M, Gaston-Massuet C
01-01-2017
IDENTIFICATION OF GENETIC VARIANTS IN A LARGE COHORT OF PATIENTS WITH CONGENITAL HYPOTHALAMO-PITUITARY DISORDERSGregory LC, Mccabe MJ, Alatzoglou KS, Turton JP, Webb EA, Kelberman D
01-01-2017
A NOVEL DENOVO FORKHEAD BOX A2 (FOXA2) MUTATION LEADS TO CONGENITAL HYPERINSULINISM, CRANIOFACIAL DYSMORPHIC FEATURES AND CONGENITAL HYPOPITUITARISMGiri D, Vignola ML, Gualtieri A, Didi M, Gaston-Massuet C
01-01-2017
2016
Transcription factor 7-like 1 is involved in hypothalamo–pituitary axis development in mice and humansGaston-Massuet C, McCabe MJ, Scagliotti V, Young RM, Carreno G, Gregory LC, Jayakody SA, Pozzi S et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 113 (5), e548-e557.
13-01-2016
The MAPK Effector BRAF is Essential for the Integrity of Hypothalamic-Pituitary Development and Deregulation of this Pathway Causes Congenital HypopituitarismGregory L, Kypranou N, Besser R, Vignola L, Davis J
01-01-2016
A Novel Mutation in Eukaryotic Translation Initiation Factor 2 Subunit 3 (EIF2S3) is Associated with X-Linked Hypopituitarism and Glucose DysregulationGregory LC, Williams H, Rahman S, Alatzoglou KS, Kapoor RR, Gaston-Massuet C, Kelberman D
01-01-2016
2015
Cell death and cell proliferation in human spina bifidaAvagliano L, Doi P, Tosi D, Scagliotti V, Gualtieri A, Gaston-Massuet C, Pistocchi A, Gallina A et al.
Birth Defects Research Part a Clinical and Molecular Teratology, Wiley vol. 106 (2), 104-113.
10-12-2015
CyclinD1 Down‐Regulation and Increased Apoptosis Are Common Features of CohesinopathiesFazio G, Gaston-Massuet C, Bettini LR, Graziola F, Scagliotti V, Cereda A, Ferrari L, Mazzola M et al.
Journal of Cellular Physiology, Wiley vol. 231 (3), 613-622.
23-11-2015
Novel application of luciferase assay for the in vitro functional assessment of KAL1 variants in three females with septo-optic dysplasia (SOD)McCabe MJ, Hu Y, Gregory LC, Gaston-Massuet C, Alatzoglou KS, Saldanha JW, Gualtieri A, Thankamony A et al.
Molecular and Cellular Endocrinology, Elsevier vol. 417, 63-72.
14-09-2015
Histopathology and molecular characterisation of intrauterine-diagnosed congenital craniopharyngiomaScagliotti V, Avagliano L, Gualtieri A, Graziola F, Doi P, Chalker J, Righini A, Korbonits M et al.
Pituitary, Springer Nature vol. 19 (1), 50-56.
09-09-2015
The role of the sonic hedgehog signalling pathway in patients with midline defects and congenital hypopituitarism.Gregory LC, Gaston-Massuet C, Andoniadou CL, Carreno G, Webb EA, Kelberman D, McCabe MJ, Panagiotakopoulos L et al.
Clin Endocrinol (Oxf) vol. 82 (5), 728-738.
01-05-2015
2014
Pituitary and NeuroendocrinologyGevers EF, Gaston-Massuet C, de Roux N
In Yearbook of Pediatric Endocrinology 2014, Karger Publishers 1-14.
01-08-2014
2013
Sox2(+) stem/progenitor cells in the adult mouse pituitary support organ homeostasis and have tumor-inducing potential.Andoniadou CL, Matsushima D, Mousavy Gharavy SN, Signore M, Mackintosh AI, Schaeffer M, Gaston-Massuet C, Mollard P et al.
Cell Stem Cell vol. 13 (4), 433-445.
03-10-2013
PituitaryGevers EF, Gaston-Massuet C
In Yearbook of Pediatric Endocrinology 2013, Karger Publishers 13-30.
01-09-2013
Variations in PROKR2, but not PROK2, are associated with hypopituitarism and septo-optic dysplasia.McCabe MJ, Gaston-Massuet C, Gregory LC, Alatzoglou KS, Tziaferi V, Sbai O, Rondard P, Masumoto K-H et al.
J Clin Endocrinol Metab vol. 98 (3), E547-E557.
01-03-2013
Nipbl expression analysis in the developing mouse embryoGraziola F, Scagliotti V, Gold-Diaz D
01-01-2013
2012
SOX2 regulates the hypothalamic-pituitary axis at multiple levels.Jayakody SA, Andoniadou CL, Gaston-Massuet C, Signore M, Cariboni A, Bouloux PM, Le Tissier P, Pevny LH et al.
J Clin Invest vol. 122 (10), 3635-3646.
01-10-2012
PituitaryGevers EF, Gaston-Massuet C
In Yearbook of Pediatric Endocrinology 2012, Karger Publishers 13-28.
11-09-2012
Identification of novel pathways involved in the pathogenesis of human adamantinomatous craniopharyngioma.Andoniadou CL, Gaston-Massuet C, Reddy R, Schneider RP, Blasco MA, Le Tissier P, Jacques TS, Pevny LH et al.
Acta Neuropathol vol. 124 (2), 259-271.
01-08-2012
2011
HESX1- and TCF3-mediated repression of Wnt/β-catenin targets is required for normal development of the anterior forebrain.Andoniadou CL, Signore M, Young RM, Gaston-Massuet C, Wilson SW, Fuchs E, Martinez-Barbera JP
Development vol. 138 (22), 4931-4942.
01-11-2011
Novel FGF8 mutations associated with recessive holoprosencephaly, craniofacial defects, and hypothalamo-pituitary dysfunction.McCabe MJ, Gaston-Massuet C, Tziaferi V, Gregory LC, Alatzoglou KS, Signore M, Puelles E, Gerrelli D et al.
J Clin Endocrinol Metab vol. 96 (10), E1709-E1718.
01-10-2011
Increased Wingless (Wnt) signaling in pituitary progenitor/stem cells gives rise to pituitary tumors in mice and humans.GASTON MASSUET JC, Andoniadou CL, Signore M, Jayakody SA, Charolidi N, Kyeyune R, Vernay B, Jacques TS et al.
Proc Natl Acad Sci U S a. vol. 108 (28), 11482-11487.
01-01-2011
Investigating genetic factors underlying hypopituitarism and septo-optic dysplasia in humansJayakody SA, Andoniadou C, Gaston-Massuet C, Pevny LH, Brue T
01-01-2011
2010
Enhancement of the Canonical Wnt Pathway in Rathke's Pouch Results in Pituitary Tumours Reminiscent of Human Adamantinomatous CraniopharyngiomaGaston-Massuet C, Andoniadou CL, Signore M, Jayakody S, Charolidi N
01-01-2010
ASPP2 Binds Par-3 and Controls the Polarity and Proliferation of Neural Progenitors during CNS DevelopmentSottocornola R, Royer C, Vives V, Tordella L, Zhong S, Wang Y, Ratnayaka I, Cheung A
Developmental Cell vol. 19 (1), 126-137.
01-01-2010
2009
Absence of SIX3 mutations in patients with congenital hypopituitarism.Gaston-Massuet C, Kelberman D
Am J Med Genet A vol. 149A (12), 2874-2876.
01-12-2009
Abstracts of papers presented at the nineteenth Genetics Society's Mammalian Genetics and Development Workshop held at the Institute of Child Health, University College London on 20 and 21 November 2008GREENE NDE, COPP AJ, PAUWS E, STANIER P, PHILPOTT A, BROS V, FLENNIKEN A, SCHIAVO G et al.
Genetics Research, Hindawi vol. 91 (2), 133-141.
01-04-2009
Hesx1 antagonises canonical Wnt signalling in anterior forebrain and pituitary glandAndoniadou CL, Gaston-Massuet C
01-01-2009
Molecular analysis of Hesx1 function in pituitary and hypothalamic developmentJayakody SA, Gaston-Massuet C, Andoniadou CL, Dattani M
01-01-2009
Role of Zic2 in mammalian neural tube closureMassa V, Ybot-Gonzalez P, Gaston-Massuet C, Greene NE
Genetics Research vol. 91 (2), 140-140.
01-01-2009
2008
Genetic interaction between the homeobox transcription factors HESX1 and SIX3 is required for normal pituitary development.Gaston-Massuet C, Andoniadou CL, Signore M, Sajedi E, Bird S, Turner JMA, Martinez-Barbera JP
Dev Biol vol. 324 (2), 322-333.
15-12-2008
Analysis of mouse models carrying the I26T and R160C substitutions in the transcriptional repressor HESX1 as models for septo-optic dysplasia and hypopituitarism.Sajedi E, Gaston-Massuet C, Signore M, Andoniadou CL, Kelberman D, Castro S, Etchevers HC, Gerrelli D et al.
Dis Model Mech vol. 1 (4-5), 241-254.
01-01-2008
DNMT1 interacts with the developmental transcriptional repressor HESX1.Sajedi E, Gaston-Massuet C, Andoniadou CL, Signore M, Hurd PJ, Dattani M, Martinez-Barbera JP
Biochim Biophys Acta vol. 1783 (1), 131-143.
01-01-2008
2007
Neural plate morphogenesis during mouse neurulation is regulated by antagonism of Bmp signalling.Ybot-Gonzalez P, Gaston-Massuet C, Girdler G, Klingensmith J, Arkell R, Greene NDE, Copp AJ
Development vol. 134 (17), 3203-3211.
01-09-2007
Abstracts of papers presented at the seventeenth Genetics Society's Mammalian Genetics and Development Workshop held at the Institute of Child Health, University College London on 9 and 10 November 2006ROMIO L, CASTRO S, LOPES C, HAMES R, FEATHER SA, FRY AM, WILSON SW, WOOLF AS et al.
Genetics Research, Hindawi vol. 89 (3), 181-188.
01-06-2007
Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrain.Andoniadou CL, Signore M, Sajedi E, Gaston-Massuet C, Kelberman D, Burns AJ, Itasaki N, Dattani M et al.
Development vol. 134 (8), 1499-1508.
01-04-2007
Lack of the murine homeobox gene Hesx1 leads to a posterior transformation of the anterior forebrainAndoniadou C, Signore M, Sajedi E
01-01-2007
2006
Role of the homeobox gene Hesx1/HESX1 in forebrain and pituitary formation in mouse and humansSajed E, Gaston-Massuet C, Signore M, Dattani M
01-01-2006
2005
Zic4, a zinc-finger transcription factor, is expressed in the developing mouse nervous system.Gaston-Massuet C, Henderson DJ, Greene NDE, Copp AJ
Dev Dyn vol. 233 (3), 1110-1115.
01-07-2005
2003
Disruption of scribble (Scrb1) causes severe neural tube defects in the circletail mouse.Murdoch JN, Henderson DJ, Doudney K, Gaston-Massuet C, Phillips HM, Paternotte C, Arkell R, Stanier P et al.
Hum Mol Genet vol. 12 (2), 87-98.
15-01-2003
Requirement for Zic2 during mouse neurulation.Gaston-Massuet C, Elms P, Arkell R
01-01-2003
Visceral Adipose Tissue Immune Homeostasis Is Regulated by the Crosstalk between Adipocytes and Dendritic Cell SubsetsCell Metabolism, Elsevier (Cell Press)
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissuesRolas L, Stein M, Barkaway A, Reglero N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al.
Embo Reports, Springer
Grants
Neurodevelopmental disorder gene pathways in syndromic intellectual disability and hypogonadismSasha Howard and Carles Gaston-Massuet
£140,412 Rosetrees Trust
08-01-2024 - 07-01-2027
Understanding the role of cellular senescence in RASopathiesCarles Gaston-Massuet
£249,918 SPARKS Charity
01-09-2023 - 31-08-2027
Characterisation and identification of novel genetic determinants of craniopharyngiomasCarles Gaston-Massuet
£405,010 Barts and the London Charity
01-09-2020 - 01-04-2026
The contribution of capsular and subcapsular progenitor cells in homeostatic adrenal cortex self-renewal and zonal-specific remodellingLeonardo Guasti, Emanuel Rognoni and Carles Gaston-Massuet
£470,140 BBSRC Biotechnology and Biological Sciences Research Council
01-11-2021 - 31-10-2024
Characterisation of novel genetic determinants of Craniopharyngioma tumoursCarles Gaston-Massuet and James Blackburn
£314,195 MRC Medical Research Council
03-03-2020 - 02-08-2023
Understanding the oncogenic mediated pro-inflammatory environment in stem cell driven hypothalamic pituitary tumoursCarles Gaston-Massuet and Rachael Kearns
£282,039 MRC Medical Research Council
04-10-2017 - 04-08-2023
Molecular Characterisation assesment of potential biomarkers and novel drug targets for childhood craniopharyngiomaCarles Gaston-Massuet
£71,591 Children with Cancer UK
01-10-2014 - 12-01-2019


