Dr Cara Croft
Senior Lecturer in Neuroscience
Blizard Institute
Queen Mary University of London
Queen Mary University of London
Research
Neurodegeneration, Alzheimer's disease, Parkinson's disease, Proteinopathy, Pharmacology, brain slice culture
Interests
My group is interested in understanding the early and late events in Alzheimer’s and Parkinson’s disease in 5D; space, time, chemistry. This will allow us to identify novel therapeutic targets in these diseases. We have expansive experience of modelling the key protein inclusions found in these neurodegenerative conditions in murine organotypic brain slice culture models which represent a 3D cytoarchitecturally relevant system that can be manipulated with recombinant adeno-associated viruses to develop pathology and for 4D imaging studies. We are now expanding these approaches to novel iPSC-derived human brain slice models for the next generation of neurodegenerative disease modelling.Publications
2024

Yang F, Beltran-Lobo P, Sung K, Goldrick C, Croft CL, Nishimura A, Hedges E, Mahiddine F, Troakes C, Golde TE, Perez-Nievas BG, Hanger DP, Noble W and Jimenez-Sanchez M
Science Advances, American Association For The Advancement of Science (Aaas) vol. 10 (12)
20-03-2024
2023

Beltran-Lobo P, Hughes MM, Troakes C, Croft CL, Rupawala H, Jutzi D, Ruepp M-D, Jimenez-Sanchez M, Perkinton MS, Kassiou M, Golde TE, Hanger DP, Verkhratsky A, Perez-Nievas BG and Noble W
Brain Behavior and Immunity, Elsevier vol. 114, 414-429.
15-09-2023
2022

Croft CL, Paterno G, Vause AR, Rowe LA, Ryu DH, Goodwin MS, Moran CA, Cruz PE, Giasson BI and Golde TE
Npj Parkinson's Disease, Springer Nature vol. 8 (1)
19-12-2022

Khalil B, Chhangani D, Wren MC, Smith CL, Lee JH, Li X, Puttinger C, Tsai C-W, Fortin G, Morderer D, Gao J, Liu F, Lim CK, Chen J, Chou C-C, Croft CL, Gleixner AM, Donnelly CJ, Golde TE, Petrucelli L, Oskarsson B, Dickson DW, Zhang K, Shorter J, Yoshimura SH, Barmada SJ, Rincon-Limas DE and Rossoll W
Molecular Neurodegeneration, Springer Nature vol. 17 (1)
08-12-2022

Xia Y, Prokop S, Bell BM, Gorion K-MM, Croft CL, Nasif L, Xu G, Riffe CJ, Manaois AN, Strang KH, Quintin SS, Paterno G, Tansey MG, Borchelt DR, Golde TE and Giasson BI
Communications Biology, Springer Nature vol. 5 (1)
12-05-2022

Moore BD, Levites Y, Xu G, Hampton H, Adamo MF, Croft CL, Futch HS, Moran C, Fromholt S, Janus C, Prokop S, Dickson D, Lewis J, Giasson BI, Golde TE and Borchelt DR
Free Neuropathology vol. 3 (9)
11-01-2022
2021

Croft CL, Goodwin MS, Ryu DH, Lessard CB, Tejeda G, Marrero M, Vause AR, Paterno G, Cruz PE, Lewis J, Giasson BI and Golde TE
Acta Neuropathologica, Springer Nature vol. 141 (3), 359-381.
26-01-2021
2020

Goodwin MS, Croft CL, Futch HS, Ryu D, Ceballos-Diaz C, Liu X, Paterno G, Mejia C, Deng D, Menezes K, Londono L, Arjona K, Parianos M, Truong V, Rostonics E, Hernandez A, Boye SL, Boye SE, Levites Y, Cruz PE and Golde TE
Molecular Neurodegeneration, Springer Nature vol. 15 (1)
02-03-2020
2019

Croft CL, Futch HS, Moore BD and Golde TE
Molecular Neurodegeneration, Springer Nature vol. 14 (1)
01-12-2019

Futch HS, McFarland KN, Moore BD, Kuhn MZ, Giasson BI, Ladd TB, Scott KA, Shapiro MR, Nosacka RL, Goodwin MS, Ran Y, Cruz PE, Ryu DH, Croft CL, Levites Y, Janus C, Chakrabarty P, Judge AR, Brusko TM, de Kloet AD, Krause EG and Golde TE
Journal of Experimental Medicine, Rockefeller University Press vol. 216 (11), 2479-2491.
29-08-2019

Croft CL, Cruz PE, Ryu DH, Ceballos-Diaz C, Strang KH, Woody BM, Lin W-L, Deture M, Rodríguez-Lebrón E, Dickson DW, Chakrabarty P, Levites Y, Giasson BI and Golde TE
Journal of Experimental Medicine, Rockefeller University Press vol. 216 (3), 539-555.
15-02-2019
2018

Futch HS and Croft CL
Journal of Neuroscience, Society For Neuroscience vol. 38 (36), 7755-7757.
05-09-2018

Croft CL and Noble W
F1000research, F1000research vol. 7
15-05-2018

Croft CL, Moore BD, Ran Y, Chakrabarty P, Levites Y, Golde TE and Giasson BI
Plos One, Public Library of Science (Plos) vol. 13 (4)
02-04-2018
2017

Strang KH, Croft CL, Sorrentino ZA, Chakrabarty P, Golde TE and Giasson BI
Journal of Biological Chemistry, Elsevier vol. 293 (7), 2408-2421.
19-12-2017

Croft CL, Kurbatskaya K, Hanger DP and Noble W
Scientific Reports, Springer Nature vol. 7 (1)
07-08-2017

Futch HS, Croft CL, Truong VQ, Krause EG and Golde TE
Molecular Neurodegeneration, Springer Nature vol. 12 (1)
21-06-2017

Croft CL, Wade MA, Kurbatskaya K, Mastrandreas P, Hughes MM, Phillips EC, Pooler AM, Perkinton MS, Hanger DP and Noble W
Cell Death & Disease, Springer Nature vol. 8 (3), e2671-e2671.
01-03-2017
2016

Kurbatskaya K, Phillips EC, Croft CL, Dentoni G, Hughes MM, Wade MA, Al-Sarraj S, Troakes C, O’Neill MJ, Perez-Nievas BG, Hanger DP and Noble W
Acta Neuropathologica Communications, Springer Nature vol. 4 (1)
31-03-2016
2015

Hughes ATL, Croft CL, Samuels RE, Myung J, Takumi T and Piggins HD
Scientific Reports, Springer Nature vol. 5 (1)
15-09-2015
2014

Phillips EC, Croft CL, Kurbatskaya K, O'Neill MJ, Hutton ML, Hanger DP, Garwood CJ and Noble W
Biochemical Society Transactions, Portland Press vol. 42 (5), 1321-1325.
18-09-2014
2013

Atherton J, Kurbatskaya K, Bondulich M, Croft CL, Garwood CJ, Chhabra R, Wray S, Jeromin A, Hanger DP and Noble W
Aging Cell, Wiley vol. 13 (1), 49-59.
18-09-2013
Grants

Cara Croft and Sarah Morgan
£243,237 Barts and the London Charity
01-01-2025 - 31-12-2028

Cara Croft
£65,936 Alzheimer's Research UK
01-07-2024 - 30-06-2025

Cara Croft
£100,000 Race Against Dementia
01-03-2024 - 31-08-2025

Cara Croft
£9,137 Alzheimer's Research UK
01-01-2024 - 30-06-2025

Cara Croft
£154,746 Alzheimer's Research UK
01-09-2023 - 31-08-2025