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Dr Claire Bourke

Claire Bourke

Lecturer/Research Fellow

Research

Immunology, Population Health, Malnutrition, Inflammation, Maternal and child health

Interests

12 years experience of in vitro models with human and murine cell lines and primary cells (parasite infection, HIV, malnutrition, birth cohorts, skin barrier, gut epithelium...). Interest in developing these into lab-on-a-chip format and new mixed cell type models from bench to bedside to facilitate functional immunology assays in low-income clinical and household.

Publications

Publications of specific relevance to Predictive in vitro Models

2021

Thompson A, Bourke C, Roberston R, Shivakumar N, Edwards C, Preston T, Holmes E, Kelly M, Frost G, Morrison D and On behalf of the HUNGer Consortium (2021). Understanding the role of the gut in undernutrition: what can technology tell us? Bmj Publishing Group  Gut  10.1136/gutjnl-2020-323609

2020

Nadimpalli ML, Bourke CD, Robertson RC, Delarocque-Astagneau E, Manges AR and Pickering AJ (2020). Can breastfeeding protect against antimicrobial resistance? Bmc Medicine  vol. 18, (1) 10.1186/s12916-020-01862-w
Bourke CD and Prendergast AJ (2020). The anti-inflammatory effects of cotrimoxazole prophylaxis for people living with human immunodeficiency virus in sub-saharan Africa. Journal of Infectious Diseases  vol. 222, (3) 347-350. 10.1093/infdis/jiz495
Gough E, Bourke C, Berejena C, Shonhai A, Bwakura-Dangarembizi M, Prendergast A and Manges AR (2020). Strain-level analysis of gut-resident pro-inflammatory viridans group Streptococci suppressed by long-term cotrimoxazole prophylaxis among HIV-positive children in Zimbabwe. Taylor & Francis  Gut Microbes  10.1080/19490976.2020.1717299

2019

Bourke C (2019). Determinants of urogenital schistosomiasis among pregnant women and its impact on pregnancy outcomes, neonatal deaths and child growth. Oxford University Press (Oup)  Journal of Infectious Diseases  10.1093/infdis/jiz664
Bourke C and Evans C (2019). Cotrimoxazole prophylaxis selects for antimicrobial resistance in HIV-exposed uninfected infants. Oxford University Press (Oup)  Clinical Infectious Diseases  10.1093/cid/ciz1193
Bourke C, Jones KDJ and Prendergast AJ (2019). Current understanding of innate immune cell dysfunction in childhood undernutrition. Frontiers Media  Frontiers in Immunology  10.3389/fimmu.2019.01728
BOURKE CD, PRENDERGAST A, DEAYTON J, PARDIEU C and Naheed C (2019). Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation. American Association For The Advancement of Science  Science Translational Medicine  vol. 11, 10.1126/scitranslmed.aav0537
Sturgeon JP, Bourke CD and PRENDERGAST AJ (2019). Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses. Ovid Technologies (Wolters Kluwer Health)  The Pediatric Infectious Disease Journal  1-1. 10.1097/inf.0000000000002311
BOURKE CD, PRENDERGAST A and ROBERTSON R (2019). Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study. Bmj Journals  Bmj Open  10.1136/bmjopen-2018-023077
Bourke C (2019). Health outcomes in Undernutrition: the role of nutrients, gut dysfunction and the gut microbiome (HUNGer). Imperial College 

2018

Freer JB, Bourke CD, Durhuus GH, Kjetland EF and Prendergast AJ (2018). Schistosomiasis in the first 1000 days. The Lancet Infectious Diseases  vol. 18, (6) e193-e203. 10.1016/S1473-3099(17)30490-5

2016

BOURKE CD, Berkley JA and Prendergast AJ (2016). Immune Dysfunction as a Cause and Consequence of Malnutrition. Elsevier (Cell Press)  Trends in Immunology  vol. 37, (6) 386-398. 10.1016/j.it.2016.04.003

2015

Sanin DE, Prendergast CT, Bourke CD and Mountford AP (2015). Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive. Plos Pathog  vol. 11, (5) 10.1371/journal.ppat.1004841
Bourke CD, Prendergast CT, Sanin DE, Oulton TE, Hall RJ and Mountford AP (2015). Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection. Int J Parasitol  vol. 45, (4) 215-224. 10.1016/j.ijpara.2014.11.002
Fukushige M, Mitchell KM, Bourke CD, Woolhouse MEJ and Mutapi F (2015). A meta-analysis of experimental studies of attenuated Schistosoma mansoni vaccines in the mouse model. Frontiers in Immunology  vol. 6, (FEB) 10.3389/fimmu.2015.00085
Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE and Mutapi F (2015). Down regulation of the TCR complex CD3ζ-chain on CD3+ T cells: A potential mechanism for helminth-mediated immune modulation. Frontiers in Immunology  vol. 6, (FEB) 10.3389/fimmu.2015.00051

2014

Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T and Mutapi F (2014). CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1. Plos Negl Trop Dis  vol. 8, (8) 10.1371/journal.pntd.0003049
Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T and Mutapi F (2014). Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment. Plos Negl Trop Dis  vol. 8, (5) 10.1371/journal.pntd.0002846
Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K and Mountford AP (2014). Circulating CD14brightCD16+ 'intermediate' monocytes exhibit enhanced parasite pattern recognition in human helminth infection. Plos Negl Trop Dis  vol. 8, (4) 10.1371/journal.pntd.0002817

2013

Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T and Mutapi F (2013). Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis. J Infect Dis  vol. 208, (1) 159-169. 10.1093/infdis/jis524
Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Dièye TN, Mboup S, Polman K and Mountford AP (2013). Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products. Parasite Immunol  vol. 35, (5-6) 147-156. 10.1111/pim.12028

2012

Bourke CD, Mutapi F, Nausch N, Photiou DMF, Poulsen LK, Kristensen B, Arnved J, Rønborg S, Roepstorff A, Thamsborg S, Kapel C, Melbye M and Bager P (2012). Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response. Clinical & Experimental Allergy  vol. 42, (11) 1582-1595. 10.1111/j.1365-2222.2012.04063.x
Nausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T and Mutapi F (2012). Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium. Sci Rep  vol. 2, 10.1038/srep00472
Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IYD, Appleby LJ, Bourke CD, Midzi N, Mduluza T and Mutapi F (2012). Age-related patterns in human myeloid dendritic cell populations in people exposed to Schistosoma haematobium infection. Plos Negl Trop Dis  vol. 6, (9) 10.1371/journal.pntd.0001824
Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE and Mutapi F (2012). Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children. Plos Negl Trop Dis  vol. 6, (11) 10.1371/journal.pntd.0001898
Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW and Mutapi F (2012). Atopy is inversely related to schistosome infection intensity: a comparative study in Zimbabwean villages with distinct levels of Schistosoma haematobium infection. Int Arch Allergy Immunol  vol. 158, (3) 288-298. 10.1159/000332949

2011

Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L and Mountford AP (2011). The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production. Int J Parasitol  vol. 41, (13-14) 1335-1345. 10.1016/j.ijpara.2011.08.005
Imai N, Rujeni N, Nausch N, Bourke CD, Appleby LJ, Cowan G, Gwisai R, Midzi N, Cavanagh D, Mduluza T, Taylor D and Mutapi F (2011). Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria. Parasitology  vol. 138, (12) 1519-1533. 10.1017/S0031182011001181
Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse MEJ, Maizels RM and Mduluza T (2011). Schistosome infection intensity is inversely related to auto-reactive antibody levels. Plos One  vol. 6, (5) 10.1371/journal.pone.0019149
Mutapi F, Rujeni N, Bourke C, Mitchell K, Appleby L, Nausch N, Midzi N and Mduluza T (2011). Schistosoma haematobium treatment in 1-5 year old children: safety and efficacy of the antihelminthic drug praziquantel. Plos Negl Trop Dis  vol. 5, (5) 10.1371/journal.pntd.0001143
MUTAPI F, BOURKE C, HARCUS Y, MIDZI N, MDULUZA T, TURNER CM, BURCHMORE R and MAIZELS RM (2011). Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4. Wiley  Parasite Immunology  vol. 33, (3) 181-192. 10.1111/j.1365-3024.2010.01270.x
Bourke CD, Maizels RM and Mutapi F (2011). Acquired immune heterogeneity and its sources in human helminth infection. Parasitology  vol. 138, (2) 139-159. 10.1017/S0031182010001216

Grants

Grants of specific relevance to Predictive in vitro Models
Novel tools for evaluating intestinal dysfunction in children and adults with malnutrition disorders
Bourke CD
£3,363,711 Medical Research Council (01-05-2021 - 30-04-2026)
The impact of microbial and inflammatory exposures on birth outcomes in rural Zimbabwe
Allaker RP, Bourke CD and Robertson RCJ
£1,214,694 MRC Medical Research Council (01-04-2020 - 31-03-2023)
The relationship between innate immune cell function and bacterial infections in severe acute malnutrition
Bourke CD
£1,159,877 Wellcome Trust (01-09-2017 - 01-09-2022)
Summary


Child health, agriculture and integrated nutrition (CHAIN): a randomized trial to close the nutrient gap in rural Zimbabwe
Bourke CD
£1,634,517 Biotechnology and Biological Sciences Research Council (01-04-2019 - 31-03-2021)
Summary