Dr Claire Bourke
Lecturer/Research Fellow
Centre for Genomics and Child Health
Queen Mary University of London
Queen Mary University of London
Research
Immunology, Population Health, Malnutrition, Inflammation, Maternal and child health
Interests
12 years experience of in vitro models with human and murine cell lines and primary cells (parasite infection, HIV, malnutrition, birth cohorts, skin barrier, gut epithelium...). Interest in developing these into lab-on-a-chip format and new mixed cell type models from bench to bedside to facilitate functional immunology assays in low-income clinical and household.Publications
Publications of specific relevance to Predictive in vitro Models2022
Smith LE, Chagwena DT, Bourke C, Robertson R, Fernando S, Tavengwa NV, Cairns J, Ndhlela T, Matumbu E, Brown T, Datta K, Mutasa B, Tengende A, Chidhanguro D, Langhaug L, Makanza M, Chasekwa B, Mutasa K, Swann J, Kelly P, Ntozini R and Prendergast A (2022). Child Health, Agriculture and Integrated Nutrition (CHAIN): protocol for a randomised controlled trial of improved infant and young child feeding in rural Zimbabwe. Bmj Open vol. 12, (12) 10.1136/bmjopen-2021-056435Gonzales GB, Bourke CD, Sturgeon JP, Njunge JM, Robertson RC, Kelly PM and Berkley JA (2022). Commentary: Mechanisms of kwashiorkor-associated immune suppression: Insights from human, mouse, and pig studies. Frontiers in Immunology vol. 13, 10.3389/fimmu.2022.959465Bourke C (2022). Stunting status and exposure to infection and inflammation in early life shape anti-bacterial immune cell function among Zimbabwean children. Frontiers Media Frontiers in Immunology vol. 13, 10.3389/fimmu.2022.8992962021
Bourke C (2021). Recovery of children following hospitalization for complicated severe acute malnutrition in Zimbabwe and Zambia. Wiley Open Access Maternal and Child Nutrition 10.1111/mcn.13302Thompson A, Bourke C, Roberston R, Shivakumar N, Edwards C, Preston T, Holmes E, Kelly M, Frost G, Morrison D and On behalf of the HUNGer Consortium (2021). Understanding the role of the gut in undernutrition: what can technology tell us? Bmj Publishing Group Gut 10.1136/gutjnl-2020-323609Bwakura-Dangarembizi M, Dumbura C, Amadi B, Ngosa D, Majo FD, Nathoo KJ, Mwakamui S, Mutasa K, Chasekwa B, Ntozini R, Kelly P and Prendergast AJ (2021). Risk factors for postdischarge mortality following hospitalization for severe acute malnutrition in Zimbabwe and Zambia. American Journal of Clinical Nutrition vol. 113, (3) 665-674. 10.1093/ajcn/nqaa3462020
Nadimpalli ML, Bourke CD, Robertson RC, Delarocque-Astagneau E, Manges AR and Pickering AJ (2020). Can breastfeeding protect against antimicrobial resistance? Bmc Medicine vol. 18, (1) 10.1186/s12916-020-01862-wBourke CD and Prendergast AJ (2020). The anti-inflammatory effects of cotrimoxazole prophylaxis for people living with human immunodeficiency virus in sub-saharan Africa. Journal of Infectious Diseases vol. 222, (3) 347-350. 10.1093/infdis/jiz495Gough E, Bourke C, Berejena C, Shonhai A, Bwakura-Dangarembizi M, Prendergast A and Manges AR (2020). Strain-level analysis of gut-resident pro-inflammatory viridans group Streptococci suppressed by long-term cotrimoxazole prophylaxis among HIV-positive children in Zimbabwe. Taylor & Francis Gut Microbes 10.1080/19490976.2020.17172992019
Bourke C (2019). Determinants of urogenital schistosomiasis among pregnant women and its impact on pregnancy outcomes, neonatal deaths and child growth. Oxford University Press (Oup) Journal of Infectious Diseases 10.1093/infdis/jiz664Bourke C and Evans C (2019). Cotrimoxazole prophylaxis selects for antimicrobial resistance in HIV-exposed uninfected infants. Oxford University Press (Oup) Clinical Infectious Diseases 10.1093/cid/ciz1193Bourke C, Jones KDJ and Prendergast AJ (2019). Current understanding of innate immune cell dysfunction in childhood undernutrition. Frontiers Media Frontiers in Immunology 10.3389/fimmu.2019.01728BOURKE CD, PRENDERGAST A, DEAYTON J, PARDIEU C and Naheed C (2019). Cotrimoxazole reduces systemic inflammation in HIV infection by altering the gut microbiome and immune activation. American Association For The Advancement of Science Science Translational Medicine vol. 11, 10.1126/scitranslmed.aav0537Sturgeon JP, Bourke CD and PRENDERGAST AJ (2019). Children With Noncritical Infections Have Increased Intestinal Permeability, Endotoxemia and Altered Innate Immune Responses. Ovid Technologies (Wolters Kluwer Health) The Pediatric Infectious Disease Journal 1-1. 10.1097/inf.0000000000002311BOURKE CD, PRENDERGAST A and ROBERTSON R (2019). Health Outcomes, Pathogenesis and Epidemiology of Severe Acute Malnutrition (HOPE-SAM): rationale and methods of a longitudinal observational study. Bmj Journals Bmj Open 10.1136/bmjopen-2018-023077Bourke C (2019). Health outcomes in Undernutrition: the role of nutrients, gut dysfunction and the gut microbiome (HUNGer). Imperial College 2018
Freer JB, Bourke CD, Durhuus GH, Kjetland EF and Prendergast AJ (2018). Schistosomiasis in the first 1000 days. The Lancet Infectious Diseases vol. 18, (6) e193-e203. 10.1016/S1473-3099(17)30490-52016
BOURKE CD, Berkley JA and Prendergast AJ (2016). Immune Dysfunction as a Cause and Consequence of Malnutrition. Elsevier (Cell Press) Trends in Immunology vol. 37, (6) 386-398. 10.1016/j.it.2016.04.0032015
Sanin DE, Prendergast CT, Bourke CD and Mountford AP (2015). Helminth Infection and Commensal Microbiota Drive Early IL-10 Production in the Skin by CD4+ T Cells That Are Functionally Suppressive. Plos Pathog vol. 11, (5) 10.1371/journal.ppat.1004841Bourke CD, Prendergast CT, Sanin DE, Oulton TE, Hall RJ and Mountford AP (2015). Epidermal keratinocytes initiate wound healing and pro-inflammatory immune responses following percutaneous schistosome infection. Int J Parasitol vol. 45, (4) 215-224. 10.1016/j.ijpara.2014.11.002Fukushige M, Mitchell KM, Bourke CD, Woolhouse MEJ and Mutapi F (2015). A meta-analysis of experimental studies of attenuated Schistosoma mansoni vaccines in the mouse model. Frontiers in Immunology vol. 6, (FEB) 10.3389/fimmu.2015.00085Appleby LJ, Nausch N, Heard F, Erskine L, Bourke CD, Midzi N, Mduluza T, Allen JE and Mutapi F (2015). Down regulation of the TCR complex CD3ζ-chain on CD3+ T cells: A potential mechanism for helminth-mediated immune modulation. Frontiers in Immunology vol. 6, (FEB) 10.3389/fimmu.2015.000512014
Appleby LJ, Nausch N, Erskine L, Bourke CD, Rujeni N, Midzi N, Mduluza T and Mutapi F (2014). CD16 expression on monocytes in healthy individuals but not schistosome-infected patients is positively associated with levels of parasite-specific IgG and IgG1. Plos Negl Trop Dis vol. 8, (8) 10.1371/journal.pntd.0003049Bourke CD, Nausch N, Rujeni N, Appleby LJ, Trottein F, Midzi N, Mduluza T and Mutapi F (2014). Cytokine responses to the anti-schistosome vaccine candidate antigen glutathione-S-transferase vary with host age and are boosted by praziquantel treatment. Plos Negl Trop Dis vol. 8, (5) 10.1371/journal.pntd.0002846Turner JD, Bourke CD, Meurs L, Mbow M, Dièye TN, Mboup S, Polman K and Mountford AP (2014). Circulating CD14brightCD16+ 'intermediate' monocytes exhibit enhanced parasite pattern recognition in human helminth infection. Plos Negl Trop Dis vol. 8, (4) 10.1371/journal.pntd.00028172013
Bourke CD, Nausch N, Rujeni N, Appleby LJ, Mitchell KM, Midzi N, Mduluza T and Mutapi F (2013). Integrated analysis of innate, Th1, Th2, Th17, and regulatory cytokines identifies changes in immune polarisation following treatment of human schistosomiasis. J Infect Dis vol. 208, (1) 159-169. 10.1093/infdis/jis524Turner JD, Meurs L, Dool P, Bourke CD, Mbow M, Dièye TN, Mboup S, Polman K and Mountford AP (2013). Schistosome infection is associated with enhanced whole-blood IL-10 secretion in response to cercarial excretory/secretory products. Parasite Immunol vol. 35, (5-6) 147-156. 10.1111/pim.120282012
Bourke CD, Mutapi F, Nausch N, Photiou DMF, Poulsen LK, Kristensen B, Arnved J, Rønborg S, Roepstorff A, Thamsborg S, Kapel C, Melbye M and Bager P (2012). Trichuris suis ova therapy for allergic rhinitis does not affect allergen-specific cytokine responses despite a parasite-specific cytokine response. Clinical & Experimental Allergy vol. 42, (11) 1582-1595. 10.1111/j.1365-2222.2012.04063.xNausch N, Bourke CD, Appleby LJ, Rujeni N, Lantz O, Trottein F, Midzi N, Mduluza T and Mutapi F (2012). Proportions of CD4+ memory T cells are altered in individuals chronically infected with Schistosoma haematobium. Sci Rep vol. 2, 10.1038/srep00472Nausch N, Louis D, Lantz O, Peguillet I, Trottein F, Chen IYD, Appleby LJ, Bourke CD, Midzi N, Mduluza T and Mutapi F (2012). Age-related patterns in human myeloid dendritic cell populations in people exposed to Schistosoma haematobium infection. Plos Negl Trop Dis vol. 6, (9) 10.1371/journal.pntd.0001824Appleby LJ, Nausch N, Bourke CD, Rujeni N, Midzi N, Mduluza T, Allen JE and Mutapi F (2012). Chitinase 3-like 1 protein levels are elevated in Schistosoma haematobium infected children. Plos Negl Trop Dis vol. 6, (11) 10.1371/journal.pntd.0001898Rujeni N, Nausch N, Bourke CD, Midzi N, Mduluza T, Taylor DW and Mutapi F (2012). Atopy is inversely related to schistosome infection intensity: a comparative study in Zimbabwean villages with distinct levels of Schistosoma haematobium infection. Int Arch Allergy Immunol vol. 158, (3) 288-298. 10.1159/0003329492011
Paveley RA, Aynsley SA, Turner JD, Bourke CD, Jenkins SJ, Cook PC, Martinez-Pomares L and Mountford AP (2011). The Mannose Receptor (CD206) is an important pattern recognition receptor (PRR) in the detection of the infective stage of the helminth Schistosoma mansoni and modulates IFNγ production. Int J Parasitol vol. 41, (13-14) 1335-1345. 10.1016/j.ijpara.2011.08.005Imai N, Rujeni N, Nausch N, Bourke CD, Appleby LJ, Cowan G, Gwisai R, Midzi N, Cavanagh D, Mduluza T, Taylor D and Mutapi F (2011). Exposure, infection, systemic cytokine levels and antibody responses in young children concurrently exposed to schistosomiasis and malaria. Parasitology vol. 138, (12) 1519-1533. 10.1017/S0031182011001181Mutapi F, Imai N, Nausch N, Bourke CD, Rujeni N, Mitchell KM, Midzi N, Woolhouse MEJ, Maizels RM and Mduluza T (2011). Schistosome infection intensity is inversely related to auto-reactive antibody levels. Plos One vol. 6, (5) 10.1371/journal.pone.0019149Mutapi F, Rujeni N, Bourke C, Mitchell K, Appleby L, Nausch N, Midzi N and Mduluza T (2011). Schistosoma haematobium treatment in 1-5 year old children: safety and efficacy of the antihelminthic drug praziquantel. Plos Negl Trop Dis vol. 5, (5) 10.1371/journal.pntd.0001143MUTAPI F, BOURKE C, HARCUS Y, MIDZI N, MDULUZA T, TURNER CM, BURCHMORE R and MAIZELS RM (2011). Differential recognition patterns of Schistosoma haematobium adult worm antigens by the human antibodies IgA, IgE, IgG1 and IgG4. Wiley Parasite Immunology vol. 33, (3) 181-192. 10.1111/j.1365-3024.2010.01270.xBourke CD, Maizels RM and Mutapi F (2011). Acquired immune heterogeneity and its sources in human helminth infection. Parasitology vol. 138, (2) 139-159. 10.1017/S0031182010001216Grants
Cell DIVE Imager for automated, single cell, multiplexed immunofluorescence microscopyBishop CL, Bourke CD, Chan LF, Dalli J, Graham TA, Licenikova Horejsi Z, Martin-Duran JM, Nourshargh S, Prendergast A and Riches J
£340,339 Wellcome Trust (20-11-2021 - 19-11-2026)
Novel tools for evaluating intestinal dysfunction in children and adults with malnutrition disordersKelly MP and Bourke CD
£3,363,711 Medical Research Council (01-05-2021 - 30-04-2026)
The impact of microbial and inflammatory exposures on birth outcomes in rural ZimbabweAllaker RP, Bourke CD, Donos N and Robertson RCJ
£1,214,694 MRC Medical Research Council (01-04-2020 - 31-03-2023)
The relationship between innate immune cell function and bacterial infections in severe acute malnutritionBourke CD
£1,159,877 Wellcome Trust (01-09-2017 - 01-09-2022)
Child health, agriculture and integrated nutrition (CHAIN): a randomized trial to close the nutrient gap in rural ZimbabweKelly MP, Brown TW and Bourke CD
£1,634,517 Biotechnology and Biological Sciences Research Council (01-04-2019 - 31-03-2021)