Dr Vito Mennella
Associate Professor, Reader in Nanoscale Biology
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Airway in vitro models, Respiratory toxicity, Asthma, COPD, rare lung diseases, Super-resolution imaging, Volume Electron Microscopy
Interests
We develop advanced in vitro models of the human respiratory tract, capturing both healthy physiology and disease states. These models allow us to explore how airway tissues are organised, how they function at the molecular level, and how they respond to harmful exposures. By studying the mechanisms through which pollutants, drugs, and chemicals affect the airways, we aim to identify pathways of toxicity and opportunities for prevention. Our work is highly collaborative, partnering with pharmaceutical and consumer product companies to generate insights that support safer and more effective treatments.Publications
2025
RPGR regulates motile cilia by interfering with actin dynamicsWu Y, Tavares E, Liang B, Wee W, Mennella V, Feng H, Cao J, Zheng J et al.
In Cold Spring Harbor Laboratory
14-03-2025
2024
ARL13B controls male reproductive tract physiology through primary and Motile CiliaAugière C, Campolina-Silva G, Vijayakumaran A, Medagedara O, Lavoie-Ouellet C, Joly Beauparlant C, Droit A, Barrachina F et al.
Communications Biology, Springer Science and Business Media Llc vol. 7 (1)
14-10-2024
3D nanoscale architecture of the respiratory epithelium reveals motile cilia-rootlets-mitochondria axis of communicationVijayakumaran A, Godbehere C, Abuammar A, Breusegem SY, Hurst LR, Morone N, Llodra J, Dalbay MT et al.
In Cold Spring Harbor Laboratory
08-09-2024
Uncovering structural themes across cilia microtubule inner proteins with implications for human cilia functionAndersen JS, Vijayakumaran A, Godbehere C, Lorentzen E, Mennella V, Schou KB
Nature Communications, Springer Science and Business Media Llc vol. 15 (1)
27-03-2024
DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signalingMao Y-Q, Seraphim TV, Wan Y, Wu R, Coyaud E, Bin Munim M, Mollica A, Laurent E et al.
Cell Reports, Elsevier Bv vol. 43 (2), 113713-113713.
01-02-2024
PrefaceMennella V
Methods in Molecular Biology vol. 2725
01-01-2024
2023
Identification of Ammonium Salts on Comet 67P/C-G Surface from Infrared VIRTIS/Rosetta Data Based on Laboratory Experiments. Implications and PerspectivesPoch O, Istiqomah I, Quirico E, Beck P, Schmitt B, Theulé P, Faure A, Hily-Blant P et al.
In Arxiv
20-11-2023
Airway Cells 3D Reconstruction via Manual and Machine-Learning Aided Segmentation of Volume EM DatasetsVijayakumaran A, Abuammar A, Medagedara O, Narayan K, Mennella V
, Springer Us, 131-146.
20-10-2023
A Novel Sandwich Method for Serial Block Face SEM Imaging of Airway Multiciliated EpitheliumMorone N, Martin MG, Goggin P, Czymmek KJ, Mennella V, Gonzalez JL
, Springer Us, 121-129.
20-10-2023
Structured Illumination MicroscopyMennella V
In Encyclopedia of Cell Biology, Elsevier 105-121.
01-01-2023
Identification of Ammonium Salts on Comet 67P/C-G Surface from Infrared VIRTIS/Rosetta Data Based on Laboratory Experiments. Implications and PerspectivesPoch O, Istiqomah I, Quirico E, Beck P, Schmitt B, Theulé P, Faure A, Hily-Blant P et al.
In Astrophysics and Space Science Proceedings, Springer International Publishing 271-279.
01-01-2023
2022
Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of MUC5BCostain G, Liu Z, Mennella V, Radicioni G, Goczi AN, Albulescu A, Walker S, Ngan B et al.
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society vol. 205 (7), 761-768.
01-04-2022
Macro and micro structures of pebble-made cometary nuclei reconciled by seasonal evolutionCiarniello M, Fulle M, Raponi A, Filacchione G, Capaccioni F, Rotundi A, Rinaldi G, Formisano M et al.
Nature Astronomy, Springer Science and Business Media Llc vol. 6 (5), 546-553.
17-03-2022
Primary Ciliary DyskinesiaMennella V, Jackson CL, Driessens C, Horton KL, Lucas JS
In Encyclopedia of Respiratory Medicine, Elsevier 188-207.
01-01-2022
Nanometer-Scale Molecular Mapping by Super-resolution Fluorescence MicroscopyMennella V, Liu Z
In Methods in Molecular Biology, Springer Us 305-326.
01-01-2022
2021
Techniques to verify the sampling system and flow characteristics of the sensor MicroMED for the ExoMars 2022 MissionCozzolino F, Franzese G, Mongelluzzo G, Molfese C, Esposito F, Ruggeri AC, Porto C, Silvestro S et al.
Measurement, Elsevier Bv vol. 185, 110075-110075.
01-11-2021
Whole genome sequencing in the diagnosis of primary ciliary dyskinesiaWheway G, Thomas NS, Carroll M, Coles J, Doherty R, Goggin P, Green B, Harris A et al.
Bmc Medical Genomics, Springer Science and Business Media Llc vol. 14 (1)
23-09-2021
A novel short isoform of ACE2 is expressed in ciliated airway epithelium and is induced by interferon and rhinovirus infection but not SARS-COV-2; implications for COVID-19 interferon treatmentJackson CL, Blume C, Spalluto CM, Mc Cormick CJ, Davies DE, Lucas JS, Mennella V, Wheway G
ERS International Congress 2021 abstracts.
05-09-2021
A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infectionBlume C, Jackson CL, Spalluto CM, Legebeke J, Nazlamova L, Conforti F, Perotin J-M, Frank M et al.
Nature Genetics, Springer Science and Business Media Llc vol. 53 (2), 205-214.
11-01-2021
2020
Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile CiliaNguyen QPH, Liu Z, Albulescu A, Ouyang H, Zlock L, Coyaud E, Laurent E, Finkbeiner W et al.
Developmental Cell, Elsevier Bv vol. 55 (2), 209-223.e7.
01-10-2020
Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated CellsLiu Z, Nguyen QPH, Nanjundappa R, Delgehyr N, Megherbi A, Doherty R, Thompson J, Jackson C et al.
Developmental Cell, Elsevier Bv vol. 55 (2), 224-236.e6.
01-10-2020
A novel isoform ofACE2is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infectionBlume C, Jackson CL, Spalluto CM, Legebeke J, Nazlamova L, Conforti F, Perotin-Collard J-M, Frank M et al.
In Cold Spring Harbor Laboratory
31-07-2020
Hereditary Mucin Deficiency Caused by Biallelic Loss-of-Function of MUC5B Defines a Novel Category of Lung DiseaseLiu Z, Costain G, Goczi A, Albulescu A, Walker S, Ngan B, Hall DA, Marshall CR et al.
American Thoracic Society 2020 International Conference, May 15-20, 2020 - Philadelphia, PA.
01-05-2020
Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosomeGopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP et al.
Nature Communications, Springer Science and Business Media Llc vol. 11 (1)
15-04-2020
A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathiesLiu Z, Nguyen QPH, Guan Q, Albulescu A, Erdman L, Mahdaviyeh Y, Kang J, Ouyang H et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 12 (535)
18-03-2020
2019
Quantitative High-Speed Video Profiling Discriminates between DNAH11 and HYDIN Variants of Primary Ciliary DyskinesiaChioccioli M, Feriani L, Nguyen Q, Kotar J, Dell SD, Mennella V, Amirav I, Cicuta P
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society vol. 199 (11), 1436-1438.
01-06-2019
Quantitative High Speed Video Profiling Discriminates Between Variants of Primary Ciliary DyskinesiaChioccioli M, Feriani L, Nguyen Q, Kotar J, Dell SDM, Mennella V, Amirav I, Cicuta P
American Thoracic Society 2019 International Conference, May 17-22, 2019 - Dallas, TX.
01-05-2019
A How-To guide to: Quantitative high-speed video profiling to discriminate between variants of primary ciliary dyskinesiaChioccioli M, Feriani L, Nguyen Q, Kotar J, Dell SD, Mennella V, Amirav I, Cicuta P
In Cold Spring Harbor Laboratory
20-04-2019
2018
Super-resolution Molecular Map of Basal Foot Reveals Novel Cilium in Airway Multiciliated CellsNguyen QPH, Liu Z, Nanjundappa R, Megherbi A, Delgehyr N, Ouyang H, Zlock L, Coyaud E et al.
In Cold Spring Harbor Laboratory
04-12-2018
PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTNSydor AM, Coyaud E, Rovelli C, Laurent E, Liu H, Raught B, Mennella V
Elife, Elife Sciences Publications, Ltd vol. 7
31-08-2018
Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell DeathWong KS, Mabanglo MF, Seraphim TV, Mollica A, Mao Y-Q, Rizzolo K, Leung E, Moutaoufik MT et al.
Cell Chemical Biology, Elsevier Bv vol. 25 (8), 1017-1030.e9.
01-08-2018
Author Correction: A novel atypical sperm centriole is functional during human fertilizationFishman EL, Jo K, Nguyen QPH, Kong D, Royfman R, Cekic AR, Khanal S, Miller AL et al.
Nature Communications, Springer Science and Business Media Llc vol. 9 (1)
13-07-2018
A novel atypical sperm centriole is functional during human fertilizationFishman EL, Jo K, Nguyen QPH, Kong D, Royfman R, Cekic AR, Khanal S, Miller AL et al.
Nature Communications, Springer Science and Business Media Llc vol. 9 (1)
07-06-2018
2017
PCD Diagnosis by Super resolution (3DSIM) microscopyDell S, Liu Z, Nguyen Q, Mennella V
ERS International Congress 2017 abstracts.
01-09-2017
2016
Centriole Remodeling during Spermiogenesis in DrosophilaKhire A, Jo KH, Kong D, Akhshi T, Blachon S, Cekic AR, Hynek S, Ha A et al.
Current Biology, Elsevier Bv vol. 26 (23), 3183-3189.
01-12-2016
The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response inDrosophilaZheng Y, Mennella V, Marks S, Wildonger J, Elnagdi E, Agard DA, Megraw TL
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 27 (11), 1740-1752.
01-06-2016
Structured Illumination MicroscopyMennella V
In Encyclopedia of Cell Biology, Elsevier 86-98.
01-01-2016
2015
Super-Resolution Microscopy: From Single Molecules to Supramolecular AssembliesSydor AM, Czymmek KJ, Puchner EM, Mennella V
Trends in Cell Biology, Elsevier Bv vol. 25 (12), 730-748.
01-12-2015
Subdiffraction resolution microscopy methods for analyzing centrosomes organizationMennella V, Hanna R, Kim M
, Elsevier, 129-152.
01-01-2015
2014
Amorphous no more: subdiffraction view of the pericentriolar material architectureMennella V, Agard DA, Huang B, Pelletier L
Trends in Cell Biology, Elsevier Bv vol. 24 (3), 188-197.
01-03-2014
2013
Cell-cycle regulation of formin-mediated actin cable assemblyMiao Y, Wong CCL, Mennella V, Michelot A, Agard DA, Holt LJ, Yates JR, Drubin DG
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 110 (47)
16-10-2013
High-resolution restoration of 3D structures from widefield images with extreme low signal-to-noise-ratioArigovindan M, Fung JC, Elnatan D, Mennella V, Chan Y-HM, Pollard M, Branlund E, Sedat JW et al.
Proceedings of The National Academy of Sciences, Proceedings of The National Academy of Sciences vol. 110 (43), 17344-17349.
08-10-2013
2012
Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organizationMennella V, Keszthelyi B, McDonald KL, Chhun B, Kan F, Rogers GC, Huang B, Agard DA
Nature Cell Biology, Springer Science and Business Media Llc vol. 14 (11), 1159-1168.
21-10-2012
2011
Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosomeGopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP et al.
Nature Communications, Springer Science and Business Media Llc vol. 2 (1)
21-06-2011
2009
Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10AMennella V, Tan D-Y, Buster DW, Asenjo AB, Rath U, Ma A, Sosa HJ, Sharp DJ
Journal of Cell Biology, Rockefeller University Press vol. 186 (4), 481-490.
17-08-2009
2006
Kinesin-13s form rings around microtubulesTan D, Asenjo AB, Mennella V, Sharp DJ, Sosa H
The Journal of Cell Biology, Rockefeller University Press vol. 175 (1), 25-31.
02-10-2006
2005
KLP10A and KLP59C: The Dynamic Duo of Microtubule DepolymerizationSharp DJ, Mennella V, Buster DW
Cell Cycle, Informa Uk Limited vol. 4 (11), 1482-1485.
22-08-2005
Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphaseMennella V, Rogers GC, Rogers SL, Buster DW, Vale RD, Sharp DJ
Nature Cell Biology, Springer Science and Business Media Llc vol. 7 (3), 235-245.
20-02-2005
2003
Identification by Phage Display of the Linear Continuous MRPr1 Epitope in the Multidrug Resistance-Associated Protein (MRP1)Flego M, Mennella V, Moretti F, Poloni F, Dupuis ML, Ascione A, Barca S, Felici F et al.
Biological Chemistry, Walter De Gruyter Gmbh vol. 384 (1), 139-142.
27-01-2003
2002
Use of phage libraries for the in vitro production of recombinant monoclonal antibodies of predetermined specificityFlego M, Ascione A, Pini A, Mennella V, Dupuis ML, Benagiano G, Cianfriglia M
Annali Dell Istituto Superiore Di Sanita vol. 38 (4), 401-410.
01-12-2002
2000
LC determination of Indinavir in biological matrices with electrochemical detectionFizzano MR, Valvo L, Dupuis ML, Mennella V, Cianfriglia M
Journal of Pharmaceutical and Biomedical Analysis, Elsevier Bv vol. 22 (2), 307-314.
01-03-2000
Grants
New Alternative Methodologies (NAMs) to replace laboratory animal inhalation studies, to predict toxVito Mennella
£2,302 Syngenta UK
01-05-2025 - 30-04-2027