Dr Vito Mennella
Associate Professor, Reader in Nanoscale Biology
School of Biological and Behavioural Sciences
Queen Mary University of London
Queen Mary University of London
Research
Airway in vitro models, Respiratory toxicity, Asthma, COPD, rare lung diseases, Super-resolution imaging, Volume Electron Microscopy
Interests
We develop advanced in vitro models of the human respiratory tract, capturing both healthy physiology and disease states. These models allow us to explore how airway tissues are organised, how they function at the molecular level, and how they respond to harmful exposures. By studying the mechanisms through which pollutants, drugs, and chemicals affect the airways, we aim to identify pathways of toxicity and opportunities for prevention. Our work is highly collaborative, partnering with pharmaceutical and consumer product companies to generate insights that support safer and more effective treatments.Publications
2024
ARL13B controls male reproductive tract physiology through primary and Motile CiliaAugière C, Campolina-Silva G, Vijayakumaran A, Medagedara O, Lavoie-Ouellet C, Joly Beauparlant C, Droit A, Barrachina F et al.
Communications Biology, Springer Nature vol. 7 (1)
14-10-2024
Uncovering structural themes across cilia microtubule inner proteins with implications for human cilia functionAndersen JS, Vijayakumaran A, Godbehere C, Lorentzen E, Mennella V, Schou KB
Nature Communications, Springer Nature vol. 15 (1)
27-03-2024
DPCD is a regulator of R2TP in ciliogenesis initiation through Akt signalingMao Y-Q, Seraphim TV, Wan Y, Wu R, Coyaud E, Bin Munim M, Mollica A, Laurent E et al.
Cell Reports, Elsevier vol. 43 (2)
01-02-2024
PrefaceMennella V
Methods in Molecular Biology vol. 2725
01-01-2024
2023
Identification of Ammonium Salts on Comet 67P/C-G Surface from Infrared VIRTIS/Rosetta Data Based on Laboratory Experiments. Implications and PerspectivesPoch O, Istiqomah I, Quirico E, Beck P, Schmitt B, Theulé P, Faure A, Hily-Blant P et al.
In Arxiv
20-11-2023
Airway Cells 3D Reconstruction via Manual and Machine-Learning Aided Segmentation of Volume EM DatasetsVijayakumaran A, Abuammar A, Medagedara O, Narayan K, Mennella V
Methods in Molecular Biology, Springer Nature vol. 2725, 131-146.
20-10-2023
A Novel Sandwich Method for Serial Block Face SEM Imaging of Airway Multiciliated EpitheliumMorone N, Martin MG, Goggin P, Czymmek KJ, Mennella V, Gonzalez JL
Methods in Molecular Biology, Springer Nature vol. 2725, 121-129.
20-10-2023
Structured Illumination MicroscopyMennella V
In Encyclopedia of Cell Biology, Elsevier 105-121.
01-01-2023
Identification of Ammonium Salts on Comet 67P/C-G Surface from Infrared VIRTIS/Rosetta Data Based on Laboratory Experiments. Implications and PerspectivesPoch O, Istiqomah I, Quirico E, Beck P, Schmitt B, Theulé P, Faure A, Hily-Blant P et al.
In European Conference On Laboratory Astrophysics Ecla2020, Springer Nature 271-279.
01-01-2023
2022
Hereditary Mucin Deficiency Caused by Biallelic Loss of Function of MUC5B.Costain G, Liu Z, Mennella V, Radicioni G, Goczi AN, Albulescu A, Walker S, Ngan B et al.
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society vol. 205 (7), 761-768.
01-04-2022
Macro and micro structures of pebble-made cometary nuclei reconciled by seasonal evolutionCiarniello M, Fulle M, Raponi A, Filacchione G, Capaccioni F, Rotundi A, Rinaldi G, Formisano M et al.
Nature Astronomy, Springer Science and Business Media Llc vol. 6 (5), 546-553.
17-03-2022
Primary Ciliary DyskinesiaMennella V, Jackson CL, Driessens C, Horton KL, Lucas JS
In Encyclopedia of Respiratory Medicine, Elsevier 188-207.
01-01-2022
Nanometer-Scale Molecular Mapping by Super-resolution Fluorescence MicroscopyMennella V, Liu Z
In Fluorescent Microscopy, Springer Nature 305-326.
01-01-2022
2021
Techniques to verify the sampling system and flow characteristics of the sensor MicroMED for the ExoMars 2022 MissionCozzolino F, Franzese G, Mongelluzzo G, Molfese C, Esposito F, Ruggeri AC, Porto C, Silvestro S et al.
Measurement, Elsevier Bv vol. 185, 110075-110075.
01-11-2021
Whole genome sequencing in the diagnosis of primary ciliary dyskinesiaWheway G, Thomas NS, Carroll M, Coles J, Doherty R, Goggin P, Green B, Harris A et al.
Bmc Medical Genomics, Springer Nature vol. 14 (1)
23-09-2021
A novel short isoform of ACE2 is expressed in ciliated airway epithelium and is induced by interferon and rhinovirus infection but not SARS-COV-2; implications for COVID-19 interferon treatmentJackson CL, Blume C, Spalluto CM, Mc Cormick CJ, Davies DE, Lucas JS, Mennella V, Wheway G
Airway cell biology and immunopathology.
05-09-2021
A novel ACE2 isoform is expressed in human respiratory epithelia and is upregulated in response to interferons and RNA respiratory virus infectionBlume C, Jackson CL, Spalluto CM, Legebeke J, Nazlamova L, Conforti F, Perotin J-M, Frank M et al.
Nature Genetics, Springer Nature vol. 53 (2), 205-214.
11-01-2021
2020
Comparative Super-Resolution Mapping of Basal Feet Reveals a Modular but Distinct Architecture in Primary and Motile CiliaNguyen QPH, Liu Z, Albulescu A, Ouyang H, Zlock L, Coyaud E, Laurent E, Finkbeiner W et al.
Developmental Cell, Elsevier vol. 55 (2), 209-223.e7.
01-10-2020
Super-Resolution Microscopy and FIB-SEM Imaging Reveal Parental Centriole-Derived, Hybrid Cilium in Mammalian Multiciliated CellsLiu Z, Nguyen QPH, Nanjundappa R, Delgehyr N, Megherbi A, Doherty R, Thompson J, Jackson C et al.
Developmental Cell, Elsevier vol. 55 (2), 224-236.e6.
01-10-2020
Hereditary Mucin Deficiency Caused by Biallelic Loss-of-Function of MUC5B Defines a Novel Category of Lung DiseaseLiu Z, Costain G, Goczi A, Albulescu A, Walker S, Ngan B, Hall DA, Marshall CR et al.
C49. PEDIATRIC CYSTIC FIBROSIS, PCD, AND COUGH.
01-05-2020
Author Correction: Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosomeGopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP et al.
Nature Communications, Springer Nature vol. 11 (1)
15-04-2020
A quantitative super-resolution imaging toolbox for diagnosis of motile ciliopathiesLiu Z, Nguyen QPH, Guan Q, Albulescu A, Erdman L, Mahdaviyeh Y, Kang J, Ouyang H et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 12 (535)
18-03-2020
2019
Quantitative High-Speed Video Profiling Discriminates between DNAH11 and HYDIN Variants of Primary Ciliary DyskinesiaChioccioli M, Feriani L, Nguyen Q, Kotar J, Dell SD, Mennella V, Amirav I, Cicuta P
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society vol. 199 (11), 1436-1438.
01-06-2019
Quantitative High Speed Video Profiling Discriminates Between Variants of Primary Ciliary DyskinesiaChioccioli M, Feriani L, Nguyen Q, Kotar J, Dell SDM, Mennella V, Amirav I, Cicuta P
D18. BEST OF NOVEL TECHNOLOGIES AND METHODOLOGIES.
01-05-2019
2018
PPP1R35 is a novel centrosomal protein that regulates centriole length in concert with the microcephaly protein RTTNSydor AM, Coyaud E, Rovelli C, Laurent E, Liu H, Raught B, Mennella V
Elife, Elife vol. 7
31-08-2018
Author Correction: A novel atypical sperm centriole is functional during human fertilizationFishman EL, Jo K, Nguyen QPH, Kong D, Royfman R, Cekic AR, Khanal S, Miller AL et al.
Nature Communications, Springer Nature vol. 9 (1)
13-07-2018
Acyldepsipeptide Analogs Dysregulate Human Mitochondrial ClpP Protease Activity and Cause Apoptotic Cell DeathWong KS, Mabanglo MF, Seraphim TV, Mollica A, Mao Y-Q, Rizzolo K, Leung E, Moutaoufik MT et al.
Cell Chemical Biology, Elsevier vol. 25 (8), 1017-1030.e9.
28-06-2018
A novel atypical sperm centriole is functional during human fertilizationFishman EL, Jo K, Nguyen QPH, Kong D, Royfman R, Cekic AR, Khanal S, Miller AL et al.
Nature Communications, Springer Nature vol. 9 (1)
07-06-2018
2017
PCD Diagnosis by Super resolution (3DSIM) microscopyDell S, Liu Z, Nguyen Q, Mennella V
Paediatric Bronchology.
01-09-2017
2016
Centriole Remodeling during Spermiogenesis in DrosophilaKhire A, Jo KH, Kong D, Akhshi T, Blachon S, Cekic AR, Hynek S, Ha A et al.
Current Biology, Elsevier vol. 26 (23), 3183-3189.
27-10-2016
The Seckel syndrome and centrosomal protein Ninein localizes asymmetrically to stem cell centrosomes but is not required for normal development, behavior, or DNA damage response in DrosophilaZheng Y, Mennella V, Marks S, Wildonger J, Elnagdi E, Agard DA, Megraw TL
Molecular Biology of The Cell, American Society For Cell Biology (Ascb) vol. 27 (11), 1740-1752.
06-04-2016
Structured Illumination MicroscopyMennella V
In Encyclopedia of Cell Biology, Elsevier 86-98.
01-01-2016
2015
Super-Resolution Microscopy: From Single Molecules to Supramolecular AssembliesSydor AM, Czymmek KJ, Puchner EM, Mennella V
Trends in Cell Biology, Elsevier vol. 25 (12), 730-748.
03-11-2015
Chapter 8 Subdiffraction resolution microscopy methods for analyzing centrosomes organizationMennella V, Hanna R, Kim M
Methods in Cell Biology, Elsevier vol. 129, 129-152.
01-01-2015
2013
Amorphous no more: subdiffraction view of the pericentriolar material architectureMennella V, Agard DA, Huang B, Pelletier L
Trends in Cell Biology, Elsevier vol. 24 (3), 188-197.
19-11-2013
Cell-cycle regulation of formin-mediated actin cable assemblyMiao Y, Wong CCL, Mennella V, Michelot A, Agard DA, Holt LJ, Yates JR, Drubin DG
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 110 (47), e4446-e4455.
16-10-2013
High-resolution restoration of 3D structures from widefield images with extreme low signal-to-noise-ratioArigovindan M, Fung JC, Elnatan D, Mennella V, Chan Y-HM, Pollard M, Branlund E, Sedat JW et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 110 (43), 17344-17349.
08-10-2013
2012
Subdiffraction-resolution fluorescence microscopy reveals a domain of the centrosome critical for pericentriolar material organizationMennella V, Keszthelyi B, McDonald KL, Chhun B, Kan F, Rogers GC, Huang B, Agard DA
Nature Cell Biology, Springer Nature vol. 14 (11), 1159-1168.
21-10-2012
2011
Sas-4 provides a scaffold for cytoplasmic complexes and tethers them in a centrosomeGopalakrishnan J, Mennella V, Blachon S, Zhai B, Smith AH, Megraw TL, Nicastro D, Gygi SP et al.
Nature Communications, Springer Nature vol. 2 (1)
21-06-2011
2009
Motor domain phosphorylation and regulation of the Drosophila kinesin 13, KLP10AMennella V, Tan D-Y, Buster DW, Asenjo AB, Rath U, Ma A, Sosa HJ, Sharp DJ
Journal of Cell Biology, Rockefeller University Press vol. 186 (4), 481-490.
17-08-2009
2006
Kinesin-13s form rings around microtubulesTan D, Asenjo AB, Mennella V, Sharp DJ, Sosa H
Journal of Cell Biology, Rockefeller University Press vol. 175 (1), 25-31.
02-10-2006
2005
KLP10A and KLP59C: The Dynamic Duo of Microtubule DepolymerizationSharp DJ, Mennella V, Buster DW
Cell Cycle, Taylor & Francis vol. 4 (11), 1482-1485.
22-08-2005
Functionally distinct kinesin-13 family members cooperate to regulate microtubule dynamics during interphaseMennella V, Rogers GC, Rogers SL, Buster DW, Vale RD, Sharp DJ
Nature Cell Biology, Springer Nature vol. 7 (3), 235-245.
20-02-2005
2003
Identification by Phage Display of the Linear Continuous MRPr1 Epitope in the Multidrug Resistance-Associated Protein (MRP1)Flego M, Mennella V, Moretti F, Poloni F, Dupuis ML, Ascione A, Barca S, Felici F et al.
Biological Chemistry, De Gruyter vol. 384 (1), 139-142.
01-01-2003
2002
Use of phage libraries for the in vitro production of recombinant monoclonal antibodies of predetermined specificity.Flego M, Ascione A, Pini A, Mennella V, Dupuis ML, Benagiano G, Cianfriglia M
Annali Dell Istituto Superiore Di Sanità vol. 38 (4), 401-410.
01-01-2002
2000
LC determination of Indinavir in biological matrices with electrochemical detectionFizzano MR, Valvo L, Dupuis ML, Mennella V, Cianfriglia M
Journal of Pharmaceutical and Biomedical Analysis, Elsevier vol. 22 (2), 307-314.
01-03-2000
RPGR regulates motile cilia by interfering with actin dynamicsWu Y, Tavares E, Liang B, Wee W, Mennella V, Feng H, Cao J, Zheng J et al.
In Biorxiv
3D nanoscale architecture of the respiratory epithelium reveals motile cilia-rootlets-mitochondria axis of communicationVijayakumaran A, Godbehere C, Abuammar A, Breusegem SY, Hurst LR, Morone N, Llodra J, Dalbay MT et al.
In Biorxiv
A novel isoform of ACE2 is expressed in human nasal and bronchial respiratory epithelia and is upregulated in response to RNA respiratory virus infectionBlume C, Jackson CL, Spalluto CM, Legebeke J, Nazlamova L, Conforti F, Perotin-Collard J-M, Frank M et al.
In Biorxiv
A How-To guide to: Quantitative high-speed video profiling to discriminate between variants of primary ciliary dyskinesiaChioccioli M, Feriani L, Nguyen Q, Kotar J, Dell SD, Mennella V, Amirav I, Cicuta P
In Biorxiv
Super-resolution Molecular Map of Basal Foot Reveals Novel Cilium in Airway Multiciliated CellsNguyen QPH, Liu Z, Nanjundappa R, Megherbi A, Delgehyr N, Ouyang H, Zlock L, Coyaud E et al.
In Biorxiv
Grants
New Alternative Methodologies (NAMs) to replace laboratory animal inhalation studies, to predict toxVito Mennella
£2,302 Syngenta UK
01-05-2025 - 30-04-2027