Prof Sussan Nourshargh

Sussan Nourshargh

Head, Centre for Microvascular Research

The William Harvey Research Institute
Queen Mary University of London
www.qmul.ac.uk/whri/people/academic-staff/items/noursharghsussan.html

Research

Inflammation, Neutrophils, Ageing, Cell Migration, Vascular Biology, Senescence

Infectious Disease and Inflammation Models

Interests

Neutrophil migration and interactions with vascular cells. Regulation of this response by vascular senescence, sterile and non-sterile stimuli and implications on vascular activation such as induction of vascular leakage.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Aging microvasculature: Effects on immune cell trafficking and inflammatory diseases

Journal of Experimental Medicine, Rockefeller University Press vol. 222 (7) 
02-06-2025

2024

Roles of the lamin A-specific tail region in the localization to sites of nuclear envelope rupture
Kono Y, Pack C-G, Ichikawa T, Komatsubara A, Adam SA, Miyazawa K, Rolas L, Nourshargh S et al.
Pnas Nexus, Oxford University Press (Oup) vol. 3 (12) 
21-11-2024
Exacerbated atherosclerosis in progeria is prevented by progerin elimination in vascular smooth muscle cells but not endothelial cells
Benedicto I, Carmona RM, Barettino A, Espinós-Estévez C, Gonzalo P, Nevado RM, de la Fuente-Pérez M, Andrés-Manzano MJ et al.
Proceedings of The National Academy of Sciences, National Academy of Sciences 
22-04-2024
Regulation of ICAM-1 in human neutrophils
Vignarajah M, Wood AJT, Nelmes E, Subburayalu J, Herre J, Nourshargh S, Summers C, Chilvers ER et al.
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 116 (4), 901-908.  
16-04-2024
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin
Cacho-Navas C, López-Pujante C, Reglero-Real N, Colás-Algora N, Cuervo A, Conesa JJ, Barroso S, de Rivas G et al.
Elife, Elife vol. 12 
10-04-2024

2023

Report from the 2023 workshop on endothelial permeability, edema and inflammation
Vestweber D, Claesson-Welsh L, McDonald DM, Williams T, Schwartz MA, Scallan J, Gavins FNE, van Buul J et al.
Nature Cardiovascular Research, Springer Science and Business Media Llc vol. 2 (12), 1120-1124.  
08-12-2023

2021

Endothelial cell autophagy keeps neutrophil trafficking under control
Reglero-Real N, Pérez-Gutiérrez L, Nourshargh S
Autophagy, Taylor and Francis vol. 17 (12), 4509-4511.  
31-10-2021
Cardiovascular Progerin Suppression and Lamin A Restoration Rescue Hutchinson-Gilford Progeria Syndrome
Sánchez-López A, Espinós-Estévez C, González-Gómez C, Gonzalo P, Andrés-Manzano MJ, Fanjul V, Riquelme-Borja R, Hamczyk MR et al.
Circulation vol. 144 (22), 1777-1794.  
25-10-2021
Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation
Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS et al.
Immunity, Elsevier Bv vol. 54 (9), 1989-2004.e9.  
01-09-2021
Isoprenylcysteine Carboxylmethyltransferase-Based Therapy for Hutchinson–Gilford Progeria Syndrome
Marcos-Ramiro B, Gil-Ordóñez A, Marín-Ramos NI, Ortega-Nogales FJ, Balabasquer M, Gonzalo P, Khiar-Fernández N, Rolas L et al.
Acs Central Science, American Chemical Society (Acs) vol. 7 (8), 1300-1310.  
27-06-2021
Circulating BMP9 Protects the Pulmonary Endothelium during Inflammation-induced Lung Injury in Mice
Li W, Long L, Yang X, Tong Z, Southwood M, King R, Caruso P, Upton PD et al.
American Journal of Respiratory and Critical Care Medicine, American Thoracic Society vol. 203 (11), 1419-1430.  
01-06-2021

2020

Local microvascular leakage promotes trafficking of activated neutrophils to remote organs
Owen-Woods C, Joulia R, Barkaway A, Rolas L, Ma B, Nottebaum FA, Arkill KP, Stein M et al.
Journal of Clinical Investigation, American Society For Clinical Investigation 
23-01-2020

2019

Dynamic trafficking and turnover of JAM-C is essential for endothelial cell migration
Kostelnik KB, Barker A, Schultz C, Mitchell TP, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S et al.
Plos Biology, Public Library of Science (Plos) vol. 17 (12) 
02-12-2019
Heparanase-dependent Remodelling of Initial Lymphatic Glycocalyx 1 Regulates Tissue-fluid Drainage during Acute Inflammation in vivo

Frontiers in Immunology, Frontiers Media 
04-10-2019
Guidelines for the use of flow cytometry and cell sorting in immunological studies (second edition)
Cossarizza A, Chang H-D, Radbruch A, Acs A, Adam D, Adam-Klages S, Agace WW, Aghaeepour N et al.
European Journal of Immunology, Wiley vol. 49 (10), 1457-1973.  
01-10-2019
Neutrophil elastase plays a non‐redundant role in remodeling the venular basement membrane and neutrophil diapedesis post‐ischemia/reperfusion injury
Voisin M, Leoni G, Woodfin A, Loumagne L, Patel NSA, Di Paola R, Cuzzocrea S, Thiemermann C et al.
The Journal of Pathology, Wiley vol. 248 (1), 88-102.  
22-03-2019
Development of a CRISPR/Cas9-based therapy for Hutchinson-Gilford progeria syndrome
NOURSHARGH S, ROLAS L, BARKAWAY A
Nature Medicine, Nature Research, 423-426.  
18-02-2019
Neutrophil trafficking to lymphoid tissues: physiological and pathological implications
Voisin M, Nourshargh S
The Journal of Pathology, Wiley vol. 247 (5), 662-671.  
04-02-2019
Leukocyte Trafficking: Time to Take Time Seriously
Reglero-Real N, Rolas L, Nourshargh S
Immunity, Elsevier vol. 50 (2), 273-275.  
01-02-2019

2018

Distinct compartmentalization of the chemokines CXCL1 and CXCL2 and the atypical receptor ACKR1 determine discrete stages of neutrophil diapedesis
GIRBL T, Lenn T, Perez L, ROLAS L, BARKAWAY A, Thiriot A, del Fresno C, Lynam E et al.
Immunity, Elsevier 
13-11-2018
Correction: Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al.
Plos Med vol. 15 (10), e1002694-e1002694.  
31-10-2018
Guidelines for the use of flow cytometry and cell sorting in immunological studies.
Cossarizza A, Chang H-D, Radbruch A, Akdis M, Andrä I, Annunziato F, Bacher P, Barnaba V et al.
Eur J Immunol vol. 47 (10), 1584-1797.  
11-05-2018
Genetic and Pharmacologic Inhibition of the Neutrophil Elastase Inhibits Experimental Atherosclerosis
Wen G, An W, Chen J, Maguire EM, Chen Q, Yang F, Pearce SWA, Kyriakides M et al.
Journal of The American Heart Association, Ovid Technologies (Wolters Kluwer Health) vol. 7 (4) 
20-02-2018
Design of an Activity-Based Probe for Human Neutrophil Elastase: Implementation of the Lossen Rearrangement To Induce Förster Resonance Energy Transfers.
Schulz-Fincke A-C, Tikhomirov AS, Braune A, Girbl T, Gilberg E, Bajorath J, Blaut M, Nourshargh S et al.
Biochemistry vol. 57 (5), 742-752.  
06-02-2018

2017

Signatures of Inflammation and Impending Multiple Organ Dysfunction in the Hyperacute Phase of Trauma
CABRERA CP, MANSON J, SHEPHERD JM, TORRANCE HD, WATSON D, LONGHI MP, HOTI M, PATEL MB et al.
Plos Medicine, Public Library of Science (Plos) 
17-07-2017
Signatures of inflammation and impending multiple organ dysfunction in the hyperacute phase of trauma: A prospective cohort study.
Cabrera CP, Manson J, Shepherd JM, Torrance HD, Watson D, Longhi MP, Hoti M, Patel MB et al.
Plos Med vol. 14 (7) 
01-07-2017
Galectin-3: A Positive Regulator of Leukocyte Recruitment in the Inflamed Microcirculation
Gittens BR, Bodkin JV, Nourshargh S, Perretti M, Cooper D
The Journal of Immunology, Oxford University Press (Oup) vol. 198 (11), 4458-4469.  
01-06-2017
Endogenous TNFα orchestrates the trafficking of neutrophils into and within lymphatic vessels during acute inflammation.

Sci Rep vol. 7, 44189-44189.  
13-03-2017

2016

Effects of PI and PIII Snake Venom Haemorrhagic Metalloproteinases on the Microvasculature: A Confocal Microscopy Study on the Mouse Cremaster Muscle.
Herrera C, Voisin M-B, Escalante T, Rucavado A, Nourshargh S, Gutiérrez JM
Plos One, Public Library of Science vol. 11 (12), e0168643-e0168643.  
16-12-2016
Endothelial Cell Junctional Adhesion Molecules
Reglero-Real N, Colom B, Bodkin JV, Nourshargh S
Arteriosclerosis, Thrombosis and Vascular Biology, American Heart Association, ATVBAHA.116-ATVBAHA.116.  
11-08-2016
Underlying chronic inflammation alters the profile and mechanisms of acute neutrophil recruitment
WHITEFORD J, Ma B, Woodfin, Nourshargh
Journal of Pathology, Wiley 
01-08-2016
Reverse Migration of Neutrophils: Where, When, How, and Why?
Nourshargh S, Renshaw SA, Imhof BA
Trends in Immunology 
04-04-2016

2015

ICAM-1–expressing neutrophils exhibit enhanced effector functions in murine models of endotoxemia
Woodfin A, Beyrau M, Voisin M-B, Ma B, Whiteford JR, Hordijk PL, Hogg N, Nourshargh S
Blood, American Society of Hematology vol. 127 (7), 898-907.  
08-12-2015
Sex-specific regulation of chemokine Cxcl5/6 controls neutrophil recruitment and tissue injury in acute inflammatory states
Madalli S, Beyrau M, Whiteford J, Duchene J, Singh Nandhra I, Patel NSA, Motwani MP, Gilroy DW et al.
Biology of Sex Differences, Springer Nature vol. 6 (1) 
26-11-2015
Novel whole blood assay for phenotyping platelet reactivity in mice identifies ICAM-1 as a mediator of platelet-monocyte interaction
Armstrong PCJ, Kirkby NS, Chan MV, Finsterbusch M, Hogg N, Nourshargh S, Warner TD
Blood, The American Society of Hematology vol. 126 (10), e11-e18.  
27-07-2015
A Targeting Microbubble for Ultrasound Molecular Imaging
Yeh JS-M, Sennoga CA, McConnell E, Eckersley R, Tang M-X, Nourshargh S, Seddon JM, Haskard DO et al.
Plos One, Public Library of Science (Plos) vol. 10 (7) 
10-07-2015
Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration InVivo
Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K et al.
Immunity vol. 42 (6), 1075-1086.  
16-06-2015
Leukotriene B4-Neutrophil Elastase Axis Drives Neutrophil Reverse Transendothelial Cell Migration In Vivo
Colom B, Bodkin JV, Beyrau M, Woodfin A, Ody C, Rourke C, Chavakis T, Brohi K et al.
Immunity, Elsevier vol. 42 (6), 1075-1086.  
01-06-2015
Quantitative Ultrasound Molecular Imaging
Yeh JS-M, Sennoga CA, McConnell E, Eckersley R, Tang M-X, Nourshargh S, Seddon JM, Haskard DO et al.
Ultrasound in Medicine & Biology, Elsevier vol. 41 (9), 2478-2496.  
01-06-2015
Tissue Localization and Extracellular Matrix Degradation by PI, PII and PIII Snake Venom Metalloproteinases: Clues on the Mechanisms of Venom-Induced Hemorrhage
Herrera C, Escalante T, Voisin M-B, Rucavado A, Morazán D, Macêdo JKA, Calvete JJ, Sanz L et al.
Plos Neglected Tropical Diseases, Public Library of Science (Plos) vol. 9 (4) 
24-04-2015

2014

Shed syndecan-2 inhibits angiogenesis.
De Rossi G, Evans AR, Kay E, Woodfin A, McKay TR, Nourshargh S, Whiteford JR
J Cell Sci vol. 127 (Pt 21), 4788-4799.  
01-11-2014
Leukocyte Migration into Inflamed Tissues
Nourshargh S, Alon R
Immunity, Elsevier vol. 41 (5), 694-707.  
01-11-2014
Neutrophils recruited by chemoattractants in vivo induce microvascular plasma protein leakage through secretion of TNF.
Finsterbusch M, Voisin M-B, Beyrau M, Williams TJ, Nourshargh S
J Exp Med vol. 211 (7), 1307-1314.  
30-06-2014
ICAM-2 facilitates luminal interactions between neutrophils and endothelial cells in vivo.
Halai K, Whiteford J, Ma B, Nourshargh S, Woodfin A
J Cell Sci vol. 127 (Pt 3), 620-629.  
01-02-2014

2013

Endothelial cell junctional adhesion molecule C plays a key role in the development of tumors in a murine model of ovarian cancer.
Leinster DA, Colom B, Whiteford JR, Ennis DP, Lockley M, McNeish IA, Aurrand-Lions M, Chavakis T et al.
Faseb J vol. 27 (10), 4244-4253.  
01-10-2013
A vasculo-protective circuit centered on lipoxin A4 and aspirin-triggered 15-epi-lipoxin A4 operative in murine microcirculation
Brancaleone V, Gobbetti T, Cenac N, le Faouder P, Colom B, Flower RJ, Vergnolle N, Nourshargh S et al.
Blood, American Society of Hematology vol. 122 (4), 608-617.  
25-07-2013
Stat2 loss leads to cytokine-independent, cell-mediated lethality in LPS-induced sepsis.
Alazawi W, Heath H, Waters JA, Woodfin A, O'Brien AJ, Scarzello AJ, Ma B, Lopez-Otalora Y et al.
Proc Natl Acad Sci U S A vol. 110 (21), 8656-8661.  
21-05-2013
L2. Neutrophil transmigration in vivo: mechanisms, dynamics and contribution to dissemination of systemic inflammation.
Nourshargh S
Presse Med vol. 42 (4 Pt 2), 498-499.  
01-04-2013
Learning in motion: pericytes instruct migrating innate leukocytes.
Alon R
Nat Immunol vol. 14 (1), 14-15.  
01-01-2013
Neutrophil transmigration: emergence of an adhesive cascade within venular walls.
Voisin M-B, Nourshargh S
J Innate Immun vol. 5 (4), 336-347.  
01-01-2013

2012

Neutrophil heterogeneity in health and disease: a revitalized avenue in inflammation and immunity.
Beyrau M, Bodkin JV, Nourshargh S
Open Biol vol. 2 (11) 
01-11-2012
Primed T Cell Responses to Chemokines Are Regulated by the Immunoglobulin-Like Molecule CD31
Kishore M, Ma L, Cornish G, MarelliBerg F
 
01-11-2012
CD31 exhibits multiple roles in regulating T lymphocyte trafficking in vivo.
Ma L, Cheung KCP, Kishore M, Nourshargh S, Mauro C, Marelli-Berg FM
J Immunol vol. 189 (8), 4104-4111.  
15-10-2012
The spatiotemporal localization of JAM-C following sciatic nerve crush in adult rats.
Avari P, Huang W, Averill S, Colom B, Imhof BA, Nourshargh S, Priestley JV
Brain Behav vol. 2 (4), 402-414.  
01-07-2012
Pericytes support neutrophil subendothelial cell crawling and breaching of venular walls in vivo.
Proebstl D, Voisin M-B, Woodfin A, Whiteford J, D'Acquisto F, Jones GE, Rowe D, Nourshargh S
J Exp Med vol. 209 (6), 1219-1234.  
04-06-2012
The peritoneal tumour microenvironment of high‐grade serous ovarian cancer
Leinster DA, Kulbe H, Everitt G, Thompson R, Perretti M, Gavins FNE, Cooper D, Gould D et al.
The Journal of Pathology, Wiley vol. 227 (2), 136-145.  
18-04-2012
Primed T cell responses to chemokines are regulated by the immunoglobulin-like molecule CD31.
Kishore M, Ma L, Cornish G, Nourshargh S, Marelli-Berg FM
Plos One vol. 7 (6) 
01-01-2012

2011

Schwann cell‐specific JAM‐C‐deficient mice reveal novel expression and functions for JAM‐C in peripheral nerves
Colom B, Poitelon Y, Huang W, Woodfin A, Averill S, Carro UD, Zambroni D, Brain SD et al.
The Faseb Journal, Wiley vol. 26 (3), 1064-1076.  
16-11-2011
Syndecan-2 is a novel ligand for the protein tyrosine phosphatase receptor CD148.
Whiteford JR, Xian X, Chaussade C, Vanhaesebroeck B, Nourshargh S, Couchman JR
Mol Biol Cell vol. 22 (19), 3609-3624.  
01-10-2011
The junctional adhesion molecule JAM-C regulates polarized transendothelial migration of neutrophils in vivo.
Woodfin A, Voisin M-B, Beyrau M, Colom B, Caille D, Diapouli F-M, Nash GB, Chavakis T et al.
Nat Immunol vol. 12 (8), 761-769.  
26-06-2011
CD97 antibody depletes granulocytes in mice under conditions of acute inflammation via a Fc receptor-dependent mechanism.
Veninga H, de Groot DM, McCloskey N, Owens BM, Dessing MC, Verbeek JS, Nourshargh S, van Eenennaam H et al.
J Leukoc Biol vol. 89 (3), 413-421.  
01-03-2011

2010

Ig gene-like molecule CD31 plays a nonredundant role in the regulation of T-cell immunity and tolerance.
Ma L, Mauro C, Cornish GH, Chai J-G, Coe D, Fu H, Patton D, Okkenhaug K et al.
Proc Natl Acad Sci U S A vol. 107 (45), 19461-19466.  
09-11-2010
The melanocortin MC1 receptor agonist BMS-470539 inhibits leucocyte trafficking in the inflamed vasculature
Leoni G, Voisin MB, Carlson K, Getting SJ, Nourshargh S, Perretti M
Brit J Pharmacol vol. 160 (1), 171-180.  
01-05-2010
Breaching multiple barriers: leukocyte motility through venular walls and the interstitium.
Nourshargh S, Hordijk PL, Sixt M
Nat Rev Mol Cell Biol vol. 11 (5), 366-378.  
01-05-2010
Recent developments and complexities in neutrophil transmigration.
Woodfin A, Voisin M-B, Nourshargh S
Curr Opin Hematol vol. 17 (1), 9-17.  
01-01-2010
Venular basement membranes ubiquitously express matrix protein low-expression regions: characterization in multiple tissues and remodeling during inflammation.
Voisin M-B, Pröbstl D, Nourshargh S
Am J Pathol vol. 176 (1), 482-495.  
01-01-2010

2009

Junctional adhesion molecule-C mediates leukocyte infiltration in response to ischemia reperfusion injury.
Scheiermann C, Colom B, Meda P, Patel NSA, Voisin M-B, Marrelli A, Woodfin A, Pitzalis C et al.
Arterioscler Thromb Vasc Biol vol. 29 (10), 1509-1515.  
01-10-2009
Monocytes and neutrophils exhibit both distinct and common mechanisms in penetrating the vascular basement membrane in vivo.
Voisin M-B, Woodfin A, Nourshargh S
Arterioscler Thromb Vasc Biol vol. 29 (8), 1193-1199.  
01-08-2009
Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1.
Woodfin A, Voisin M-B, Imhof BA, Dejana E, Engelhardt B, Nourshargh S
Blood vol. 113 (24), 6246-6257.  
11-06-2009
Endothelial cell activation leads to neutrophil transmigration as supported by the sequential roles of ICAM-2, JAM-A, and PECAM-1
Woodfin A, Voisin MB, Imhof BA, Dejana E
Blood vol. 113 (24), 6246-6257.  
11-06-2009
Experimental autoimmune vasculitis: an animal model of anti-neutrophil cytoplasmic autoantibody-associated systemic vasculitis.
Little MA, Smyth L, Salama AD, Mukherjee S, Smith J, Haskard D, Nourshargh S, Cook HT et al.
Am J Pathol vol. 174 (4), 1212-1220.  
01-04-2009

2007

PECAM-1: a multi-functional molecule in inflammation and vascular biology.
Woodfin A, Voisin M-B, Nourshargh S
Arterioscler Thromb Vasc Biol vol. 27 (12), 2514-2523.  
01-12-2007
Expression and function of junctional adhesion molecule-C in myelinated peripheral nerves.
Scheiermann C, Meda P, Aurrand-Lions M, Madani R, Yiangou Y, Coffey P, Salt TE, Ducrest-Gay D et al.
Science vol. 318 (5855), 1472-1475.  
30-11-2007
JAM family and related proteins in leukocyte migration (Vestweber series).
Bradfield PF, Nourshargh S, Aurrand-Lions M, Imhof BA
Arterioscler Thromb Vasc Biol vol. 27 (10), 2104-2112.  
01-10-2007
JAM-C regulates unidirectional monocyte transendothelial migration in inflammation.
Bradfield PF, Scheiermann C, Nourshargh S, Ody C, Luscinskas FW, Rainger GE, Nash GB, Miljkovic-Licina M et al.
Blood vol. 110 (7), 2545-2555.  
01-10-2007
JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration.
Woodfin A, Reichel CA, Khandoga A, Corada M, Voisin M-B, Scheiermann C, Haskard DO, Dejana E et al.
Blood vol. 110 (6), 1848-1856.  
15-09-2007
Getting to the site of inflammation: the leukocyte adhesion cascade updated.
Ley K, Laudanna C, Cybulsky MI, Nourshargh S
Nat Rev Immunol vol. 7 (9), 678-689.  
01-09-2007
JAM-A mediates neutrophil transmigration in a stimulus-specific manner in vivo: Evidence for sequential roles for JAM-A and PECAM-1 in neutrophil transmigration
NOURSHARGH S, Krombach F, Dejana E, Khandoga A, Woodfin A, Reichal AC, Scheiermann C, Voisin MB
Blood vol. 110 (6), 1848-1856.  
01-09-2007
Role of neutrophil elastase in LTB4-induced neutrophil transmigration in vivo assessed with a specific inhibitor and neutrophil elastase deficient mice.
Young RE, Voisin M-B, Wang S, Dangerfield J, Nourshargh S
Br J Pharmacol vol. 151 (5), 628-637.  
01-07-2007
PECAM-1 & JAM-A mediate leukocyte transmigration in a stimulus-specific manner: Is this phenomenon governed by the strain of mice investigated?
Woodfin A, Larbi K, Krombach F
 
01-04-2007
Neutrophil and monocyte transmigration elicited by ischemia/reperfusion (I/R) injury and CCL2 is associated with remodelling of the venular basement membrane (BM) in vivo
Voisin MB, Woodfin A
 
01-04-2007
Efficient clearance of opsonised apoptotic cells in the absence of PECAM-1.
Potter PK, Larbi KY, Nourshargh S, Botto M
Mol Immunol vol. 44 (6), 1135-1140.  
01-02-2007
Microbulles ciblées pour ľimagerie ultrasonore
Sennoga CA, Yeh JS, Seddon JM, Nourshargh S, Eckersley RJ, Haskard DO, Cosgrove DO, Nihoyannopoulos P
In ÉChographie De Contraste, Springer Nature 321-328.  
01-01-2007
Role of α6β1 integrin in leukocyte adhesion and transmigration
Voisin M-B
In Adhesion Molecules: Function and Inhibition, Springer Nature 221-235.  
01-01-2007

2006

The role of JAM-A and PECAM-1 in modulating leukocyte infiltration in inflamed and ischemic tissues.
Nourshargh S, Krombach F, Dejana E
J Leukoc Biol vol. 80 (4), 714-718.  
01-10-2006
Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils
Wang S, Voisin M-B, Larbi KY, Dangerfield J, Tran M
Journal of Cell Biology, Rockefeller University Press vol. 173 (6), i11-i11.  
19-06-2006
ICAM-2 mediates neutrophil transmigration in vivo: evidence for stimulus specificity and a role in PECAM-1-independent transmigration.
Huang M-T, Larbi KY, Scheiermann C, Woodfin A, Gerwin N, Haskard DO, Nourshargh S
Blood vol. 107 (12), 4721-4727.  
15-06-2006
Venular basement membranes contain specific matrix protein low expression regions that act as exit points for emigrating neutrophils.
Wang S, Voisin M-B, Larbi KY, Dangerfield J, Scheiermann C, Tran M, Maxwell PH, Sorokin L et al.
J Exp Med vol. 203 (6), 1519-1532.  
12-06-2006
JAM-A mediates leukocyte transmigration in a stimulus-specific manner
Woodfin A, Reichel C, Khandoga A, Corada M, Dejana E
 
07-03-2006
Neutrophil elastase (NE) deficient mice exhibit reduced leukocyte transmigration in response to ischaemia/reperfusion (I/R) injury
Voisin MB, Woodfin A, Dawes T, Nourshargh S
 
07-03-2006
Neutrophils play a direct role in enhancing the size of venular basement membrane (BM) matrix protein low expression regions
Voisin MB, Wang SJ, Larbi K, Scheiermann C, Sorokin L
 
07-03-2006
Neutrophil chemorepulsion in defined interleukin-8 gradients in vitro and in vivo.
Tharp WG, Yadav R, Irimia D, Upadhyaya A, Samadani A, Hurtado O, Liu S-Y, Munisamy S et al.
J Leukoc Biol vol. 79 (3), 539-554.  
01-03-2006
Therapeutic effect of anti-TNF-alpha antibodies in an experimental model of anti-neutrophil cytoplasm antibody-associated systemic vasculitis.
Little MA, Bhangal G, Smyth CL, Nakada MT, Cook HT, Nourshargh S, Pusey CD
 
01-01-2006
JAM-A mediates leukocyte transmigration dynamically and in a stimulus-specific manner
Reichel CA, Khandoga A, Woodfin A, Corada M, Dejana E
 
01-01-2006

2005

Anti-proteinase 3 antibody binding to neutrophils as demonstrated by confocal microscopy.
Ambrose LR, Little MA, Pusey CD
Kidney Int vol. 68 (6), 2912-2913.  
01-12-2005
Intravital microscopy in the study of ANCA-associated systemic vasculitis.
Little MA, Pusey CD, Nourshargh S
 
01-12-2005
Antineutrophil cytoplasm antibodies directed against myeloperoxidase augment leukocyte-microvascular interactions in vivo.
Little MA, Smyth CL, Yadav R, Ambrose L, Cook HT, Nourshargh S, Pusey CD
Blood vol. 106 (6), 2050-2058.  
15-09-2005
Annexin 1-deficient neutrophils exhibit enhanced transmigration in vivo and increased responsiveness in vitro
Chatterjee BE, Yona S, Rosignoli G, Young RE, Nourshargh S, Flower RJ, Perretti M
J Leukocyte Biol vol. 78 (3), 639-646.  
01-09-2005
Mechanisms of Leukocyte Transmigration: Role of Immunoglobulin Superfamily Molecules
Marelli‐Berg FM
In Leukocyte Trafficking, Wiley 82-108.  
23-08-2005
Junctional adhesion molecule-C regulates the early influx of leukocytes into tissues during inflammation.
Aurrand-Lions M, Lamagna C, Dangerfield JP, Wang S, Herrera P, Nourshargh S, Imhof BA
J Immunol vol. 174 (10), 6406-6415.  
15-05-2005
PECAM-1, alpha6 integrins and neutrophil elastase cooperate in mediating neutrophil transmigration.
Wang S, Dangerfield JP, Young RE, Nourshargh S
J Cell Sci vol. 118 (Pt 9), 2067-2076.  
01-05-2005
ICAM-2 mediates PECAM-1-independent neutrophil transmigration in vivo
Huang MT, Larbi KY, Nourshargh S
 
07-03-2005
LTB4 is a potent inducer of cell surface neutrophil elastase (NE), a response that appears to play a role in LTB4-induced neutrophil transmigration in vivo
Voisin MB, Young R, Dangerfield J, Wijayasiri L, Wang SJ
 
07-03-2005
Pre-formed matrix protein low expression regions act as exit points for leukocytes migrating through the venular perivascular basement membrane
Wang SJ, Dangerfield J, Voisin MB, Tran M
 
07-03-2005
Transmigration through venular walls: a key regulator of leukocyte phenotype and function.
Nourshargh S, Marelli-Berg FM
Trends Immunol vol. 26 (3), 157-165.  
01-03-2005
Blockade of alpha6 integrin inhibits IL-1beta- but not TNF-alpha-induced neutrophil transmigration in vivo.
Dangerfield JP, Wang S, Nourshargh S
J Leukoc Biol vol. 77 (2), 159-165.  
01-02-2005

2004

Cognate recognition of the endothelium induces HY-specific CD8+ T-lymphocyte transendothelial migration (diapedesis) in vivo.
Marelli-Berg FM, James MJ, Dangerfield J, Dyson J, Millrain M, Scott D, Simpson E, Nourshargh S et al.
Blood vol. 103 (8), 3111-3116.  
15-04-2004
Neutrophil Elastase (NE)-Deficient Mice Demonstrate a Nonredundant Role for NE in Neutrophil Migration, Generation of Proinflammatory Mediators, and Phagocytosis in Response to Zymosan Particles In Vivo
Young RE, Thompson RD, Larbi KY, La M, Roberts CE, Shapiro SD, Perretti M, Nourshargh S
The Journal of Immunology, Oxford University Press (Oup) vol. 172 (7), 4493-4502.  
01-04-2004
Murine CD93 (C1qRp) contributes to the removal of apoptotic cells in vivo but is not required for C1q-mediated enhancement of phagocytosis.
Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ et al.
J Immunol vol. 172 (6), 3406-3414.  
15-03-2004
Matrix metalloproteinase-9 deficiency results in enhanced allergen-induced airway inflammation.
McMillan SJ, Kearley J, Campbell JD, Zhu X-W, Larbi KY, Shipley JM, Senior RM, Nourshargh S et al.
J Immunol vol. 172 (4), 2586-2594.  
15-02-2004

2003

Migration of leukocytes through the vessel wall and beyond
Yadav R, Larbi KY, Nourshargh S
Thrombosis and Haemostasis vol. 90 (4), 598-606.  
01-10-2003
Anergic T cells exert antigen-independent inhibition of cell-cell interactions via chemokine metabolism.
James MJ, Belaramani L, Prodromidou K, Datta A, Nourshargh S, Lombardi G, Dyson J, Scott D et al.
Blood vol. 102 (6), 2173-2179.  
15-09-2003
MRL/lpr lupus-prone mice show exaggerated ICAM-1-dependent leucocyte adhesion and transendothelial migration in response to TNF-alpha.
Marshall D, Dangerfield JP, Bhatia VK, Larbi KY, Nourshargh S, Haskard DO
Rheumatology (Oxford) vol. 42 (8), 929-934.  
01-08-2003
MMP-9 regulates eosinophil transmigration and expression of CCR3 on transmigrated eosinophils in vivo
Larbi KY, Dangerfield JP, Nourshargh S
 
17-03-2003
Neutrophil elastase (NE) plays a non-redundant role in zymosan-induced leukocyte migration
Young RE, Thompson RD, Larbi KY, La M, Roberts C, Shapir SD, Perretti M, Nourshargh S
 
01-01-2003
P-selectin mediates IL-13-induced eosinophil transmigration but not eotaxin generation in vivo: a comparative study with IL-4-elicited responses.
Larbi KY, Dangerfield JP, Culley FJ, Marshall D, Haskard DO, Jose PJ, Williams TJ, Nourshargh S
J Leukoc Biol vol. 73 (1), 65-73.  
01-01-2003

2002

Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta and tumour necrosis factor-alpha in mouse cremasteric venules.
Young RE, Thompson RD, Nourshargh S
Br J Pharmacol vol. 137 (8), 1237-1246.  
01-12-2002
PECAM-1 (CD31) homophilic interaction up-regulates alpha6beta1 on transmigrated neutrophils in vivo and plays a functional role in the ability of alpha6 integrins to mediate leukocyte migration through the perivascular basement membrane.
Dangerfield J, Larbi KY, Huang M-T, Dewar A, Nourshargh S
J Exp Med vol. 196 (9), 1201-1211.  
04-11-2002
MRL/lpr LUPUS-PRONE MICE SHOW EXAGGERATED ICAM-1 DEPENDENT LEUKOCYTE-ENDOTHELIAL INTERACTIONS IN RESPONSE TO TNF alpha
Marshall D, Dangerfield JD, Bhatia VK, Larbi KY
Rheumatology vol. 41, 32-32.  
01-04-2002
Divergent mechanisms of action of the inflammatory cytokines interleukin 1-beta (IL-1 beta) and factor-alpha (TNF alpha) in mouse cremasteric venules.
Young RE, Thompson RD
Brit J Pharmacol vol. 135 
01-03-2002

2001

Platelet-endothelial cell adhesion molecule-1 (PECAM-1)-deficient mice demonstrate a transient and cytokine-specific role for PECAM-1 in leukocyte migration through the perivascular basement membrane.
Thompson RD, Noble KE, Larbi KY, Dewar A, Duncan GS, Mak TW, Nourshargh S
Blood vol. 97 (6), 1854-1860.  
15-03-2001
Expression of P- but not E-selectin in peritoneal microvasculature during inflammatory peritonitis
Marshall D, Bhatia VK, Ahmed S, Lidington EA, Larbi KY, Nourshargh S
Faseb J vol. 15 (4), A328-A328.  
07-03-2001

2000

VCAM-1 has a tissue-specific role in mediating interleukin-4-induced eosinophil accumulation in rat models: evidence for a dissociation between endothelial-cell VCAM-1 expression and a functional role in eosinophil migration.
Larbi KY, Allen AR, Tam FWK, Haskard DO, Lobb RR, Silva PMR, Nourshargh S
Blood, American Society of Hematology vol. 96 (10), 3601-3609.  
15-11-2000
An anti-inflammatory property of aprotinin detected at the level of leukocyte extravasation
Asimakopoulos G, Thompson R, Nourshargh S, Lidington EA, Mason JC, Ratnatunga CP, Haskard DO, Taylor KM et al.
Journal of Thoracic and Cardiovascular Surgery, Elsevier vol. 120 (2), 361-369.  
01-08-2000
Divergent Effects of Platelet-Endothelial Cell Adhesion Molecule-1 and β3 Integrin Blockade on Leukocyte Transmigration In Vivo
Thompson RD, Wakelin MW, Larbi KY, Dewar A, Horton MA
The Journal of Immunology, Oxford University Press (Oup) vol. 165 (1), 426-434.  
01-07-2000

1999

VCAM‐1 contributes to rapid eosinophil accumulation induced by the chemoattractants PAF and LTB4: evidence for basal expression of functional VCAM‐1 in rat skin
DAVIES¶, LARBI, ALLEN, WEG, NOURSHARGH
Immunology, Wiley vol. 97 (1), 150-158.  
01-05-1999
Human eotaxin induces eosinophil extravasation through rat mesenteric venules: role of α4 integrins and vascular cell adhesion molecule‐1
NAGAI, LARKIN§, HARTNELL, LARBI, WINDLEY, DAVIES
Immunology, Wiley vol. 96 (2), 176-183.  
01-02-1999

1998

IL-4-induced eosinophil accumulation in rat skin is dependent on endogenous TNF-alpha and alpha 4 integrin/VCAM-1 adhesion pathways.
Sanz M-J, Marinova-Mutafchieva L, Green P, Lobb RR, Feldmann M, Nourshargh S
The Journal of Immunology, Oxford University Press (Oup) vol. 160 (11), 5637-5645.  
01-06-1998
Human eotaxin induces alpha 4 and beta 2 integrin-dependent eosinophil accumulation in rat skin in vivo: delayed generation of eotaxin in response to IL-4.
Sanz M-J, Ponath PD, Mackay CR, Newman W, Miyasaka M, Tamatani T, Flanagan BF, Lobb RR et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 160 (7), 3569-3576.  
01-04-1998

1997

TNFα and IFNγ act synergistically to induce leukocyte rolling and adhesion but not extravasation in vivo
Wakelin MW, Nourshargh S
Faseb Journal vol. 11 (3) 
01-12-1997
Tumor Necrosis Factor α-Induced Eosinophil Accumulation in Rat Skin Is Dependent on α4 Integrin/Vascular Cell Adhesion Molecule-1 Adhesion Pathways
Sanz M-J, Hartnell A, Chisholm P, Williams C, Davies D, Feldmann M, Bolanowski MA
Blood, American Society of Hematology vol. 90 (10), 4144-4152.  
15-11-1997
Adhesion molecules and asthma.
Nourshargh S
 
01-05-1997

1996

An anti-platelet-endothelial cell adhesion molecule-1 antibody inhibits leukocyte extravasation from mesenteric microvessels in vivo by blocking the passage through the basement membrane.
Wakelin MW, Sanz MJ, Dewar A, Albelda SM, Larkin SW, Boughton-Smith N, Williams TJ, Nourshargh S
Journal of Experimental Medicine, Rockefeller University Press vol. 184 (1), 229-239.  
01-07-1996

1995

Molecular and cellular interactions mediating granulocyteaccumulation in vivo
Nourshargh S, Williams TJ
Seminars in Cell and Developmental Biology, Elsevier vol. 6 (6), 317-326.  
01-12-1995
Interleukin-1-Induced Leukocyte Extravasation Across Rat Mesenteric Microvessels Is Mediated by Platelet-Activating Factor
Nourshargh S, Larkin SW, Das A
Blood, American Society of Hematology vol. 85 (9), 2553-2558.  
01-05-1995
Substance P‐induced inflammatory responses in guinea‐pig skin: The effect of specific NK1 receptor antagonists and the role of endogenous mediators
Walsh DT, Weg VB, Williams TJ
British Journal of Pharmacology, Wiley vol. 114 (7), 1343-1350.  
01-04-1995
IL-1 is a potent inducer of eosinophil accumulation in rat skin. Inhibition of response by a platelet-activating factor antagonist and an anti-human IL-8 antibody.
Sanz MJ, Weg VB, Bolanowski MA
The Journal of Immunology, Oxford University Press (Oup) vol. 154 (3), 1364-1373.  
01-02-1995
LPS-induced 111In-eosinophil accumulation in guinea-pig skin: evidence for a role for TNF-alpha.
Weg VB, Walsh DT, Faccioli LH, Williams TJ
Immunology vol. 84 (1), 36-40.  
01-01-1995
Lung eosinophilia is dependent on IL-5 and the adhesion molecules CD18 and VLA-4, in a guinea-pig model.
Das AM, Williams TJ, Lobb R
Immunology vol. 84 (1), 41-46.  
01-01-1995

1994

Differential effects of the PAF receptor antagonist UK‐74,505 on neutrophil and eosinophil accumulation in guinea‐pig skin
Sanz MJ, Weg VB, Walsh DT
British Journal of Pharmacology, Wiley vol. 113 (2), 513-521.  
01-10-1994
The role of PAF in platelet accumulation and oedema formation in rabbit skin
Rossi AG, Norman KE, Williams TJ
 
01-01-1994

1993

Mechanisms of Neutrophil and Eosinophil Accumulation In Vivo
Nourshargh S
 
01-12-1993
Role of platelet‐activating factor (PAF) in platelet accumulation in rabbit skin: effect of the novel long‐acting PAF antagonist, UK‐74,505
Pons F, Rossi AG, Williams TJ
British Journal of Pharmacology, Wiley vol. 109 (1), 234-242.  
01-05-1993
Effect of dexamethasone on neutrophil accumulation and oedema formation in rabbit skin: an investigation of site of action
Yarwood H, Nourshargh S, Brain S
British Journal of Pharmacology, Wiley vol. 108 (4), 959-966.  
01-04-1993
A monoclonal antibody recognizing very late activation antigen-4 inhibits eosinophil accumulation in vivo.
Weg VB, Williams TJ, Lobb RR, Nourshargh S
Journal of Experimental Medicine, Rockefeller University Press vol. 177 (2), 561-566.  
01-02-1993

1992

Comparative responses of human and rabbit interleukin-1 in vivo: effect of a recombinant interleukin-1 receptor antagonist.
von Uexküll C, Nourshargh S
Immunology vol. 77 (4), 483-487.  
01-12-1992
A comparative study of the neutrophil stimulatory activity in vitro and pro-inflammatory properties in vivo of 72 amino acid and 77 amino acid IL-8.
Nourshargh S, Perkins JA, Showell HJ, Matsushima K, Williams TJ, Collins PD
The Journal of Immunology, Oxford University Press (Oup) vol. 148 (1), 106-111.  
01-01-1992

1991

Mechanism of action of platelet activating factor in the pulmonary circulation: an investigation using a novel isotopic system in rabbit isolated lung
Seale JP, Nourshargh S, Hellewell PG
British Journal of Pharmacology, Wiley vol. 104 (1), 251-257.  
01-09-1991
Neutrophils in Asthmaa
WILLIAMS TJ, DAS A, von UEXKULL C
Annals of The New York Academy of Sciences, Wiley vol. 629 (1), 73-81.  
01-07-1991
The accumulation of 111In-eosinophils induced by inflammatory mediators, in vivo.
Faccioli LH, Nourshargh S, Moqbel R, Sehmi R, Kay AB
Immunology vol. 73 (2), 222-227.  
01-06-1991

1990

Evidence that a receptor-operated event on the neutrophil mediates neutrophil accumulation in vivo. Pretreatment of 111In-neutrophils with pertussis toxin in vitro inhibits their accumulation in vivo.
Nourshargh S, Williams TJ
The Journal of Immunology, Oxford University Press (Oup) vol. 145 (8), 2633-2638.  
15-10-1990
Neutrophil-endothelial cell interactions in microvascular tone and permeability changes
Williams TJ, Von Uexkull C
 
01-07-1990

1989

Accumulation of 111In-neutrophils in rabbit skin in allergic and non-allergic inflammatory reactions in vivo. Inhibition by neutrophil pretreatment in vitro with a monoclonal antibody recognizing the CD18 antigen.
Nourshargh S, Rampart M, Hellewell PG, Jose PJ, Harlan JM, Edwards AJ, Williams TJ
The Journal of Immunology, Oxford University Press (Oup) vol. 142 (9), 3193-3198.  
01-05-1989

1988

Alteration in microvascular permeability induced by products released during inflammation.
Williams TJ, Brain SD, Jose PJ, Rampart M
Progress in Clinical and Biological Research vol. 263, 55-69.  
01-01-1988

1987

Divergent effects of co‐carcinogenic phorbol esters and a synthetic diacylglycerol on human neutrophil chemokinesis and granular enzyme secretion
Nourshargh S, Hoult JRS
British Journal of Pharmacology, Wiley vol. 91 (3), 557-568.  
01-07-1987

1986

Inhibition of human neurophil degranulation by forskolin in the presence of phosphodiesterase inhibitors
Nourshargh S
European Journal of Pharmacology, Elsevier vol. 122 (2), 205-212.  
01-03-1986

1985

Phorbol myristate acetate enhances human polymorphonuclear neutrophil release of granular enzymes but inhibits chemokinesis
Hoult JRS, Nourshargh S
British Journal of Pharmacology, Wiley vol. 86 (3), 533-537.  
01-11-1985

Leukocytes use endothelial membrane tunnels to extravasate the vasculature

Cell Reports, Cell Press 
Leukocytes breach endothelial barriers by insertion of nuclear lobes and disassembly of endothelial actin filaments

Cell Reports, Elsevier 
Human CD8+ EMRA T cells display a senescent-associated secretory phenotype regulated by p38 MAPK.
HENSON SM, Callender LA, Carroll EC, Beal RWJ, Chamber ES, Nourshargh S, Akbar AN
Aging Cell, Wiley Open Access 
Age-related changes in the local milieu of inflamed tissues cause aberrant neutrophil trafficking and subsequent remote organ damage
Barkaway A, Rolas L, Joulia R, Bodkin J, Lenn T, Owen-Woods C, Reglero-Real N, Stein M et al.
Immunity, Elsevier 
Isoprenylcysteine carboxylmethyltransferase-based therapy for Hutchinson–Gilford progeria syndrome

In Biorxiv 
Dynamic trafficking and turnover of Jam-C is essential for endothelial cell migration
Kostelnik KB, Barker A, Schultz C, Rajeeve V, White IJ, Aurrand-Lions M, Nourshargh S, Cutillas P et al.
In Biorxiv 
Neutrophil breaching of the blood vessel pericyte layer during diapedesis requires mast cell-derived IL-17A

Nature Communications, Nature Research 
ICAM-1 nanoclusters regulate hepatic epithelial cell polarity by leukocyte adhesion-independent control of apical actomyosin

In Biorxiv 
Delayed localization of A-type lamins to the rupture sites in Hutchinson–Gilford progeria syndrome

In Biorxiv 
Senescent endothelial cells promote pathogenic neutrophil trafficking in inflamed tissues
Rolas L, Stein M, Barkaway A, Reglero N, Sciacca E, Yaseen M, Wang H, Vazquez-Martinez L et al.
Embo Reports, Springer 
Protocol for volume correlative light Xray and electron microscopy of endothelial cells in mouse tissue

Star Protocols, Cell Press 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconNeutrophils re-entering the circulation from a primary site of inflammation:Physiological or pathol?
Sussan Nourshargh
£1,964,639 Wellcome Trust
16-01-2022 - 15-04-2028
bullet iconScreening for, and characterisation of, novel immune cell extravasation genes in Drosophila, mice and man
Sussan Nourshargh
£867,504 MRC Medical Research Council
01-06-2021 - 03-10-2026

bullet iconThe role of Cortactin in regulation of neutrophil transendothelial cell migration dynamics.
Sussan Nourshargh
£63,000 Royal Society
04-06-2018 - 03-05-2021
bullet iconImpact of mast cells on neutrophil-pericyte interactions & neutrophil effector functions: Role of IL-17A?
Sussan Nourshargh and Mathieu-Benoit Voisin
£241,442 BHF British Heart Foundation
01-01-2018 - 30-06-2021
bullet iconMultiphoton confocal microscope
Sussan Nourshargh
£219,948 BHF British Heart Foundation
01-07-2017 - 30-06-2018
bullet iconDissecting the role of TNFR1 And TNFR2
Sussan Nourshargh
£104,696 BBSRC Biotechnology and Biological Sciences Research Council
01-10-2016 - 30-09-2020
bullet iconDissecting the role of TNFR1 and TNFR2 in driving neutrophil reverse transendothelial cell migration and pulmonary edema
Sussan Nourshargh
£42,000 GSK GlaxoSmithKline UK Ltd
01-10-2016 - 30-09-2020
bullet iconHigh resolution live cell imaging for investigations into JAM-C in endothelial cell functions and phenotype
Sussan Nourshargh
£126,724 Wellcome Trust
01-07-2015 - 30-06-2019
bullet iconUse of a combined flow sytometer/microscopy imaging platform
Sussan Nourshargh
£399,636 Wellcome Trust
01-10-2013 - 30-09-2018
bullet iconMode and dynamics of neutrophil transmigration in vivo
Sussan Nourshargh
£2,625,434 Wellcome Trust
16-01-2013 - 15-01-2022
bullet iconMode and dynamics of neutrophil transmigration in vivo
Sussan Nourshargh
£55,875 EU European Commission - Other
16-01-2013 - 30-11-2018