Dr Ryan O'Shaughnessy

Ryan O'Shaughnessy

Reader in Cell Biology

FMD/Blizard/Centre for Cell Biology and Cutaneous Research
Queen Mary University of London
www.qmul.ac.uk/blizard/all-staff/profiles/ryan-oshaughnessy.html
ORCID LinkedIn

Research

Epidermal biology, Epidermal barrier function, Ichthyosis, Squamous Cell Carcinoma, Wound healing, Scarring

Cancer Models, Skin Models

Interests

I have a interest in using in vitro models to model disease states and also healthy skin to determine disease mechanisms and also mechanisms important to skin homeostasis. Current relevant expertise is in organotypic, skin equivalent culture, using shRNA knockdown to model human disease.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Adding arginine to the list of single amino acids important in epidermal barrier function
O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 193 (1), 7-8.  
25-03-2025

2024

195 Reduced filaggrin expression reduces ERK signalling and disrupts desmosomes in atopic eczema
Hughes A, Coppock L, Tachie-Menson T, Bjorn T, Doykov I, MIlls K, O’Toole EA, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 144 (12), S261-S261.  
01-12-2024
P038 Impact of cumulative low-level ozone on keratinocytes and implications for atopic eczema pathogenesis
Tawfik S, Thomas B, Caley M, Jones E, O’Shaughnessy R, O’Toole E
British Journal of Dermatology, Oxford University Press (Oup) vol. 191 (Supplement_1), i31-i32.  
28-06-2024
P15 Understanding the role of cathepsin H in atopic dermatitis pathogenesis
Tachie-Menson T, Hughes A, O’Toole E, O’Shaughnessy R
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (6), e85-e86.  
17-05-2024
Loss-of-function FLG mutations are associated with reduced history of acne vulgaris in a cohort of patients with atopic eczema of Bangladeshi ancestry in East London
Hughes AJ, Barbosa E, Cernova J, Thomas BR, O’Shaughnessy RFL, O’Toole EA
Clinical and Experimental Dermatology, Oxford University Press (Oup) vol. 49 (12), 1547-1553.  
15-05-2024

2023

Editorial: Novel aspects of the immunological and structural barrier of the epidermis
O’Shaughnessy R, Common J, Gutowska-Owsiak D
Frontiers in Molecular Biosciences, Frontiers Media Sa vol. 10 
01-11-2023
Why are squamous cancers so aggressive in recessive dystrophic epidermolysis bullosa? Can we find new therapeutic approaches?
O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 190 (1), 7-8.  
13-10-2023
Loss of cholesterol in Junctional Epidermolysis Bullosa skin identifies a key role for Laminin-332 in actomyosin mediated cholesterol transport
Jones EM, Camera E, Parzymies P, Marsh ST, O’Shaughnessy RF, Aumailley M, McGrath JA, O’Toole EA et al.
In Cold Spring Harbor Laboratory 
11-09-2023
O14 Junctional epidermolysis bullosa: repairing the epidermal lipid barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O’Toole E, Caley M
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e10-e10.  
07-07-2023
P27 Uncovering the roles of lysosomal protease cathepsin H in atopic dermatitis
Tachie-Menson T, Azizah A, Hughes A, O'Shaughnessy R
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), e24-e25.  
07-07-2023
P102 Severe atopic eczema is associated with reduced acne vulgaris in Bangladeshi children and young adults: a retrospective analysis from a cross-sectional study
Hughes A, Barbosa E, Cernova J, Thomas B, O’Toole, E, O'Shaughnessy R
British Journal of Dermatology, Oxford University Press (Oup) vol. 188 (Supplement_4) 
26-06-2023
770 AKT1-dependent protease control of skin barrier function and inflammation in atopic dermatitis
Tachie-Menson T, Azizah A, Hughes A, O'Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 143 (5), S132-S132.  
01-05-2023
1157 Ozone as an aggravating factor in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E
Journal of Investigative Dermatology, Elsevier Bv vol. 143 (5), S198-S198.  
01-05-2023
786 IL-4 stimulates IL-1R2 upregulation in atopic dermatitis keratinocytes
Baruah K, Koh L, Tham K, O'Shaughnessy R, O'Toole E, Common JE
Journal of Investigative Dermatology, Elsevier Bv vol. 143 (5), S135-S135.  
01-05-2023
ISID1157 - Ozone as an aggravating factor in atopic eczema
Tawfik S, O'Toole E, Thomas B, Caley M, Jones E, O'Shaughnessy R
 
29-04-2023
Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype
Tagoe H, Hassan S, Bliss E, Youssef G, Heywood W, Mills K, Harper JI, O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 189 (1), 91-102.  
27-03-2023
Ozone as an aggravating factor in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E
 
01-01-2023
AKT1-dependent protease control of skin barrier function and inflammation in atopic dermatitis
Tachie-Menson T, Azizah A, Hughes A, O'Shaughnessy R
 
01-01-2023
IL-4 stimulates IL-1R2 upregulation in atopic dermatitis keratinocytes
Baruah K, Koh L, Tham K, O'Shaughnessy R, O'Toole E, Common JE
 
01-01-2023

2022

191 Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O’Shaughnessy R, Aumailley M, McGrath JA, O’Toole EA, Caley MP
Journal of Investigative Dermatology, Elsevier Bv vol. 142 (12), S213-S213.  
01-12-2022
183 Reduced FLG expression in atopic eczema reduces expression of key barrier genes and increases BMP signalling
Hughes AJ, Thomas B, O’Toole EA, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 142 (12), S211-S211.  
01-12-2022
174 Defining the composition and function of Lamin ribonuclear bodies during keratinocyte terminal differentiation and nuclear degradation
Wotherspoon DJ, Tachie-Menson T, Rogerson C, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 142 (12), S210-S210.  
01-12-2022
144 Carbonylated proteins and Ozone in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley MP, O’Shaughnessy R, O’Toole EA
Journal of Investigative Dermatology, Elsevier Bv vol. 142 (12), S204-S204.  
01-12-2022
Phosphoproteomic analysis of the AKT signalling axis in cutaneous squamous carcinoma progression reveals novel therapeutic targets
Button R, Harwood C, O’Shaughnessy RFL
In Cold Spring Harbor Laboratory 
05-10-2022
ESDR144 - Carbonylated proteins and Ozone in atopic eczema
Tawfik S, Thomas B, Jones E, Caley M, O'Shaughnessy R, O'Toole E, Thomas B, Prasad Baruah K
 
26-09-2022
ESDR174 - Defining the composition and function of Lamin ribonuclear bodies during keratinocyte terminal differentiation and nuclear degradation
Wotherspoon D, Tachie-Menson T, Rogerson C, O'Shaughnessy R
 
26-09-2022
ESDR191 - Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath J, O'Toole E, Caley M
 
22-09-2022
Chronic activation of Toll-like receptor 2 induces an ichthyotic skin phenotype
Tagoe H, Hassan S, Youssef G, Heywood W, Mills K, Harper JI, O’Shaughnessy RFL
In Cold Spring Harbor Laboratory 
06-06-2022
Reduced filaggrin expression is associated with increased BMP signalling
Hughes A, Thomas B, O'Toole E, O'Shaughnessy R
 
01-01-2022
Quality of life in Bangladeshi children and families with atopic eczema
Tawfik SS, Thomas B, Robinson EJ, Ahmed R, Begum R, Khanam H, Kelsell D, O'Shaughnessy R et al.
 
01-01-2022
Characterizing novel Akt substrates in squamous cell carcinoma identified N-myc downstream-regulated gene 2 and iron chelation as a novel treatment modality
Button R, Harwood C, O'Shaughnessy R
 
01-01-2022
Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation
Rogerson C, Wotherspoon D, O'Shaughnessy R
 
01-01-2022
Carbonylated proteins as markers of oxidative stress and their association with filaggrin genotype in atopic eczema
Tawfik S, Baruah K, Hughes A, Thomas B, O-Shaughnessy R, Toole EO
 
01-01-2022
Carbonylated proteins and Ozone in atopic eczema
Tawfik SS, Thomas B, Jones E, Caley MP, O'Shaughnessy R, O'Toole EA
 
01-01-2022
Reduced FLG expression in atopic eczema reduces expression of key barrier genes and increases BMP signalling
Hughes AJ, Thomas B, O'Toole EA, O'Shaughnessy R
 
01-01-2022
Junctional Epidermolysis Bullosa:Repairing The Epidermal Skin Barrier
Jones E, Marsh S, O'Shaughnessy R, Aumailley M, McGrath JA, O'Toole EA, Caley MP
 
01-01-2022
Defining the composition and function of Lamin ribonuclear bodies during keratinocyte terminal differentiation and nuclear degradation
Wotherspoon DJ, Tachie-Menson T, Rogerson C, O'Shaughnessy R
 
01-01-2022

2021

Understanding the paradoxical proinflammatory effects of an immunosuppressant
O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 185 (6), 1091-1092.  
08-11-2021
282 Phosphoproteomic profiling of AKT-related changes in cutaneous squamous cell carcinoma identified DNA-dependent protein kinase (DNA-PK) and N-Myc downstream regulator 2 (NDRG2) as therapeutic vulnerabilities
Button R, Harwood C, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 141 (10), S197-S197.  
01-10-2021
111 Single cell RNA seq revealed altered cytoskeletal dynamics and the formation of cytoplasmic RNA-Lamin A bodies during keratinocyte terminal differentiation
Wotherspoon DJ, Rogerson C, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 141 (10), S167-S167.  
01-10-2021
132 Increased BMP Signalling Correlates with Increased Eczema Severity
Hughes AJ, Thomas B, O’Toole EA, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 141 (10), S170-S170.  
01-10-2021
Ceramide kinase‐like protein, ‘the kinase that isn’t’, finds a role in skin cancer stress relief
O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 185 (1), 14-15.  
23-03-2021
Tape strips in dermatology research*
Hughes AJ, Tawfik SS, Baruah KP, O’Toole EA, O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 185 (1), 26-35.  
01-03-2021
Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation
Rogerson C, Wotherspoon DJ, Tommasi C, Button RW, O’Shaughnessy RFL
Cell Death &Amp; Differentiation, Springer Science and Business Media Llc vol. 28 (6), 1849-1864.  
18-01-2021
Increased BMP Signalling Correlates with Increased Eczema Severity
Hughes AJ, Thomas B, O'Toole EA, O'Shaughnessy R
 
01-01-2021
Phosphoproteomic profiling of AKT-related changes in cutaneous squamous cell carcinoma identified DNA-dependent protein kinase (DNA-PK) and N-Myc downstream regulator 2 (NDRG2) as therapeutic vulnerabilities
Button R, Harwood C, O'Shaughnessy R
 
01-01-2021
Single cell RNA seq revealed altered cytoskeletal dynamics and the formation of cytoplasmic RNA-Lamin A bodies during keratinocyte terminal differentiation
Wotherspoon DJ, Rogerson C, O'Shaughnessy R
 
01-01-2021

2020

Perspective: Controlling Epidermal Terminal Differentiation with Transcriptional Bursting and RNA Bodies
Wotherspoon D, Rogerson C, O’Shaughnessy RFL
Journal of Developmental Biology, Mdpi Ag vol. 8 (4), 29-29.  
04-12-2020
Ubiquitin, a novel therapeutic target in psoriasis?
O’Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 184 (1), 8-9.  
21-07-2020
Kallikrein-Mediated Cytokeratin 10 Degradation Is Required for Varicella Zoster Virus Propagation in Skin
Tommasi C, Rogerson C, Depledge DP, Jones M, Naeem AS, Venturini C, Frampton D, Tutill HJ et al.
Journal of Investigative Dermatology, Elsevier Bv vol. 140 (4), 774-784.e11.  
01-04-2020

2019

Akt1-associated actomyosin remodelling is required for nuclear lamina dispersal and nuclear shrinkage in epidermal terminal differentiation
Rogerson C, Wotherspoon D, O’Shaughnessy RFL
In Cold Spring Harbor Laboratory 
08-12-2019
Understanding actinic keratosis to reduce squamous cell carcinoma incidence
O'Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 182 (4), 834-835.  
16-10-2019
PLCD1 and Pilar Cysts
Shimomura Y, O’Shaughnessy R, Rajan N
Journal of Investigative Dermatology, Elsevier Bv vol. 139 (10), 2075-2077.  
01-10-2019
Sonic Hedgehog signaling limits atopic dermatitis via Gli2-driven immune regulation
Papaioannou E, Yánez DC, Ross S, Lau C-I, Solanki A, Chawda MM, Virasami A, Ranz I et al.
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 129 (8), 3153-3170.  
02-07-2019
341 Epidermal nuclear degradation during terminal differentiation involves cytoplasmic dispersal of lamina proteins and rapid nuclear shrinkage
Rogerson C, O'Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 139 (5), S59-S59.  
01-05-2019
Differential expression of secreted factors\n \n SOSTDC\n 1\n \n and\n \n ADAMTS\n 8\n \n cause profibrotic changes in linear morphoea fibroblasts
Badshah II, Brown S, Weibel L, Rose A, Way B, Sebire N, Inman G, Harper J et al.
British Journal of Dermatology, Oxford University Press (Oup) vol. 180 (5), 1135-1149.  
06-01-2019
Targeting tryptophan transport and breakdown in basal cell carcinoma
O'Shaughnessy RFL
British Journal of Dermatology, Oxford University Press (Oup) vol. 180 (1), 16-17.  
01-01-2019

2018

Protein kinases involved in epidermal barrier formation: The AKT family and other animals
Rogerson C, O'Shaughnessy RFL
Experimental Dermatology, Wiley vol. 27 (8), 892-900.  
01-08-2018
909 Kallikrein 6 (KLK6) mediated keratin 10 degradation is required for VZV propagation in skin
Tommasi C, Breuer J, O'Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 138 (5), S154-S154.  
01-05-2018
Orchestrated control of filaggrin–actin scaffolds underpins cornification
Gutowska-Owsiak D, de La Serna JB, Fritzsche M, Naeem A, Podobas EI, Leeming M, Colin-York H, O’Shaughnessy R et al.
Cell Death &Amp; Disease, Springer Science and Business Media Llc vol. 9 (4) 
15-03-2018
Uncovering mechanisms of nuclear degradation in keratinocytes: A paradigm for nuclear degradation in other tissues
Rogerson C, Bergamaschi D, O'Shaughnessy RFL
Nucleus, Informa Uk Limited vol. 9 (1), 56-64.  
03-01-2018

2017

Persistent kallikrein 5 activation induces atopic dermatitis-like skin architecture independent of PAR2 activity
Zhu Y, Underwood J, Macmillan D, Shariff L, O'Shaughnessy R, Harper JI, Pickard C, Friedmann PS et al.
Journal of Allergy and Clinical Immunology, Elsevier Bv vol. 140 (5), 1310-1322.e5.  
01-11-2017
Phosphoinositide 3-Kinase-Dependent Signalling Pathways in Cutaneous Squamous Cell Carcinomas
Janus J, O’Shaughnessy R, Harwood C, Maffucci T
Cancers, Mdpi Ag vol. 9 (7), 86-86.  
11-07-2017
A mechanistic target of rapamycin complex 1/2 (mTORC1)/V-Akt murine thymoma viral oncogene homolog 1 (AKT1)/cathepsin H axis controls filaggrin expression and processing in skin, a novel mechanism for skin barrier disruption in patients with atopic dermatitis
Naeem AS, Tommasi C, Cole C, Brown SJ, Zhu Y, Way B, Willis Owen SAG, Moffatt M et al.
Journal of Allergy and Clinical Immunology, Elsevier Bv vol. 139 (4), 1228-1241.  
01-04-2017
CD161+ Tconv and CD161+ Treg Share a Transcriptional and Functional Phenotype despite Limited Overlap in TCRβ Repertoire
Duurland CL, Brown CC, O’Shaughnessy RFL, Wedderburn LR
Frontiers in Immunology, Frontiers Media Sa vol. 8 
06-03-2017

2016

131 Epidermal autophagy and nucleophagy
Akinduro O, Harwood CA, O’Shaughnessy R, Bergamaschi D
 
01-09-2016
393 KLK6-mediated down-regulation of Keratin10 is commonly employed by skin-tropic viruses to propagate in skin and is required for blister formation in VZV infection
Tommasi C, Depledge D, Duddy D, Jones M, Pfister H, Akgul B, Breuer J, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 136 (9), S227-S227.  
01-09-2016
429 Defining a common mechanism that leads to scaling in Autosomal Recessive Congenital Ichthyoses
Tagoe H, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 136 (9), S233-S233.  
01-09-2016
565 A novel role for the ETS family transcription factor ERG in hypertrophic scarring
Way B, Brown S, Bulstrode N, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 136 (9), S257-S257.  
01-09-2016
108 Targeting the toll-like receptor pathway to treat scaling in the autosomal recessive congenital ichthyoses
Hassan S, Tagoe H, Youssef G, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 136 (9), S179-S179.  
01-09-2016
Constitutive Autophagy and Nucleophagy during Epidermal Differentiation
Akinduro O, Sully K, Patel A, Robinson DJ, Chikh A, McPhail G, Braun KM, Philpott MP et al.
Journal of Investigative Dermatology, Elsevier Bv vol. 136 (7), 1460-1470.  
01-07-2016
483 MDM2 binds and ubiquitinates keratin 10 in VZV infection and is required for viral propagation and blister formation
Tomassi C, Depledge D, Otto R, Tan W, Duddy D, Breuer J, O’Shaughnessy R
Journal of Investigative Dermatology, Elsevier Bv vol. 136 (5), S85-S85.  
01-05-2016
Mosaic Activating Mutations in GNA11 and GNAQ Are Associated with Phakomatosis Pigmentovascularis and Extensive Dermal Melanocytosis
Thomas AC, Zeng Z, Rivière J-B, O’Shaughnessy R, Al-Olabi L, St.-Onge J, Atherton DJ, Aubert H et al.
Journal of Investigative Dermatology, Elsevier Bv vol. 136 (4), 770-778.  
01-04-2016

2015

AKT1-mediated Lamin A/C degradation is required for nuclear degradation and normal epidermal terminal differentiation
Naeem AS, Zhu Y, Di WL, Marmiroli S, O'Shaughnessy RFL
Cell Death &Amp; Differentiation, Springer Science and Business Media Llc vol. 22 (12), 2123-2132.  
05-06-2015
Insight from the Air–Skin Interface
O'Shaughnessy RFL, Brown SJ
Journal of Investigative Dermatology, Elsevier Bv vol. 135 (2), 331-333.  
01-02-2015

2014

A novel microdeletion inLORcausing autosomal dominant loricrin keratoderma
Kinsler VA, Drury S, Khan A, Waelchli R, Rukaite G, Barnicoat A, Lench N, Harper JI et al.
British Journal of Dermatology, Oxford University Press (Oup) vol. 172 (1), 262-264.  
09-12-2014
CD161+ regulatory t cells in immune regulation
Duurland C, Brooks T, Hubank M, O'Shaughnessy R, Wedderburn L
Pediatric Rheumatology, Springer Science and Business Media Llc vol. 12 (S1) 
01-09-2014
Identifying a Hyperkeratosis Signature in Autosomal Recessive Congenital Ichthyosis: Mdm2 Inhibition Prevents Hyperkeratosis in a Rat ARCI Model
Youssef G, Ono M, Brown SJ, Kinsler VA, Sebire NJ, Harper JI, O'Shaughnessy RFL
Journal of Investigative Dermatology, Elsevier Bv vol. 134 (3), 858-861.  
01-03-2014

2013

PReS-FINAL-1021: Further characterization of CD161+ regulatory t cells in health and disease
Duurland CL, Chain G, O'Shaughnessy RF, Pesenacker AM, Wedderburn LR
Pediatric Rheumatology, Springer Science and Business Media Llc vol. 11 (S2) 
01-12-2013
The protein phosphatase 2A regulatory subunit Ppp2r2a is required for Connexin‐43 dephosphorlyation during epidermal barrier acquisition
Gerner L, Youssef G, O'Shaughnessy RFL
Experimental Dermatology, Wiley vol. 22 (11), 754-756.  
29-10-2013
Rab3Gap1 mediates exocytosis of Claudin-1 and tight junction formation during epidermal barrier acquisition
Youssef G, Gerner L, Naeem AS, Ralph O, Ono M, O’Neill CA, O’Shaughnessy RFL
Developmental Biology, Elsevier Bv vol. 380 (2), 274-285.  
01-08-2013
T-Cell Reconstitution after Thymus Xenotransplantation Induces Hair Depigmentation and Loss
Furmanski AL, O'Shaughnessy RFL, Saldana JI, Blundell MP, Thrasher AJ, Sebire NJ, Davies EG, Crompton T
Journal of Investigative Dermatology, Elsevier Bv vol. 133 (5), 1221-1230.  
01-05-2013
Constitutive autophagy as a terminal differentiation mechanism
Akinduro O, Sully K, Chikh A, O'shaughnessy RF, Bergamaschi D, Harwood CA, Philpott MP, Byrne C
 
01-01-2013

2012

Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis
O'Shaughnessy RFL, Chaudhury I, Harper JI
Human Molecular Genetics, Oxford University Press (Oup) vol. 22 (5), 1059-1059.  
18-12-2012
The mTOR inhibitor rapamycin opposes carcinogenic changes to epidermal Akt1/PKBα isoform signaling
Sully K, Akinduro O, Philpott MP, Naeem AS, Harwood CA, Reeve VE, O'Shaughnessy RF, Byrne C
Oncogene, Springer Science and Business Media Llc vol. 32 (27), 3254-3262.  
13-08-2012
AKT1 Loss Correlates with Episomal HPV16 in Vulval Intraepithelial Neoplasia
Ekeowa-Anderson AL, Purdie KJ, Gibbon K, Byrne CR, Arbeit JM, Harwood CA, O'Shaughnessy RFL
Plos One, Public Library of Science (Plos) vol. 7 (6), e38608-e38608.  
07-06-2012
Autophagy in epidermis
Akinduro O, Sully K, O'Shaughnessy RFL, Harwood CA, Bergamaschi D, Byrne C
 
01-01-2012
A Novel Mechanism of Keratinocyte Terminal Differentiation - Autophagy?
Akinduro O, Sully K, O'Shaughnessy R, Harwood CA, Bergamaschi D, Byrne C
 
01-01-2012

2011

TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier
Jackson B, Brown SJ, Avilion AA, O'Shaughnessy RFL, Sully K, Akinduro O, Murphy M, Cleary ML et al.
Development vol. 138 (11), 1681-1690.  
01-06-2011
TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier
Jackson B, Brown SJ, Avilion AA, O'Shaughnessy RFL, Sully K, Akinduro O, Murphy M, Cleary ML et al.
Development, The Company of Biologists vol. 138 (11), e1-e1.  
01-06-2011
TALE homeodomain proteins regulate site-specific terminal differentiation, LCE genes and epidermal barrier
Jackson B, Brown SJ, Avilion AA, O'Shaughnessy RFL, Sully K, Akinduro O, Murphy M, Cleary ML et al.
J Cell Sci vol. 124 (10), 1681-1690.  
15-05-2011
Understanding the tumour-suppressing role of rapamycin in epidermis
Sully K, Akinduro O, O'Shaughnessy RF, Harwood CA, Byrne C
 
01-01-2011
Rapamycin treatment increases mTORC2 activity and selectively activates the AKT1 isoform in epidermis by inhibition of the mTORC1-dependent feedback loop to IRS-1
Sully K, Akinduro OA, Philpott MP, Harwood CA, O'Shaughnessy RF, Byrne C
 
01-01-2011

2010

Interleukin-1 alpha blockade prevents hyperkeratosis in an in vitro model of lamellar ichthyosis
O'Shaughnessy RFL, Choudhary I, Harper JI
Human Molecular Genetics, Oxford University Press (Oup) vol. 19 (13), 2594-2605.  
12-04-2010
Whole-mount assays for gene induction and barrier formation in the developing epidermis.
Byrne C, Avilion AA, O'Shaughnessy RF, Welti JC, Hardman MJ
Methods in Molecular Biology Clifton N J vol. 585, 271-286.  
01-01-2010

2009

Akt-dependent Pp2a activity is required for epidermal barrier formation during late embryonic development
O'Shaughnessy RFL, Welti JC, Sully K, Byrne C
Development vol. 136 (20), 3423-3431.  
15-10-2009
Whole-Mount Assays for Gene Induction and Barrier Formation in the Developing Epidermis
Byrne C, Avilion AA, O’Shaughnessy RF, Welti JC, Hardman MJ
, Humana Press, 271-286.  
05-09-2009
AKT-dependent protein phosphatase 2A activity is necessary for epidermal barrier function and the correct formation of the cornified layer
O'Shaughnessy RFL, Welti JC, Byrne CR
 
01-01-2009

2008

Akt-dependent, protein phosphatase 2A-mediated formation of tight junctions is an initial component of the epidermal permeability barrier
O'Shaughnessy RFL, Welti JC, Byrne CR
 
01-01-2008

2007

Cutaneous human Papillomaviruses down-regulate AKT1, whereas AKT2 up-regulation and activation associates with tumors
O'Shaughnessy RFL, Akgul B, Storey A, Pfister H, Harwood CA, Byrne C
Cancer Res vol. 67 (17), 8207-8215.  
01-09-2007
AKT-dependent HspB1 (hsp27) activity in epidermal differentiation
O'Shaughnessy RFL, Welti JC, Cooke JC, Avilion AA, Monks B, Birnbaum MJ, Byrne C
J Biol Chem vol. 282 (23), 17297-17305.  
08-06-2007
Cutaneous human papillomavirus early genes downregulate serine phosphorylated Akt1 while upregulating Akt2 expression
O'Shaughnessy RFL, Akgul B, Storey A, Pfister H, Harwood CA, Byrne C
 
01-01-2007
Epidermal AKT signalling regulates SREBP transcription, epidermal lipogenesis and skin barrier activity
Welti JC, O'Shaughnessy RFL, Byrne C
 
01-01-2007

2006

Cutaneous HPV early genes target epidermal AKT activity, altering heat-shock protein regulation of cornification
O'Shaughnessy R, Welti J, Pfister H, Harwood C, Byrne C
 
01-01-2006

2004

The WNT Signalling Modulator, Wise, is Expressed in an Interaction-Dependent Manner During Hair-Follicle Cycling
O'Shaughnessy RFL, Yeo W, Gautier J, Jahoda CAB, Christiano AM
Journal of Investigative Dermatology, Elsevier Bv vol. 123 (4), 613-621.  
01-10-2004
The role of BMP signalling in the control of ID3 expression in the hair follicle
O'Shaughnessy RFL, Christiano AM, Jahoda CAB
Experimental Dermatology, Wiley vol. 13 (10), 621-629.  
24-09-2004
The lanceolate hair rat phenotype results from a missense mutation in a calcium coordinating site of the desmoglein 4 gene
Jahoda CAB, Kljuic A, O'Shaughnessy R, Crossley N, Whitehouse CJ, Robinson M, Reynolds AJ, Demarchez M et al.
Genomics, Elsevier Bv vol. 83 (5), 747-756.  
01-05-2004
Inherited disorders of the skin in human and mouse: from development to differentiation.
O'Shaughnessy RFL, Christiano AM
The International Journal of Developmental Biology, Upv/Ehu Press vol. 48 (2-3), 171-179.  
01-01-2004

2003

Desmoglein 4 in Hair Follicle Differentiation and Epidermal Adhesion
Kljuic A, Bazzi H, Sundberg JP, Martinez-Mir A, O'Shaughnessy R, Mahoney MG, Levy M, Montagutelli X et al.
Cell, Elsevier Bv vol. 113 (2), 249-260.  
01-04-2003

2001

Analysis of Gene Expression Using High-Density and IFN-γ-Specific Low-Density cDNA Arrays
Aberger F, Costa-Pereira AP, Schlaak JF, Williams TM, O'Shaughnessy RFL, Hollaus G, Kerr IM, Frischauf A-MM
Genomics, Elsevier Bv vol. 77 (1-2), 50-57.  
01-09-2001
Stem Cells in the Epidermis
O’Shaughnessy RFL, Christiano AM
Skin Pharmacology and Physiology, S. Karger Ag vol. 14 (6), 350-357.  
01-01-2001

2000

PA‐FABP, a novel marker of human epidermal transit amplifying cells revealed by 2D protein gel electrophoresis and cDNA array hybridisation
O'Shaughnessy RFL, Seery JP, Celis JE, Frischauf A-M, Watt FM
Febs Letters, Wiley vol. 486 (2), 149-154.  
07-12-2000

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconInvestigating mTOR inhibition by Lactobacillus Rhamnosus lysates to treat atopic dermatitis
Ryan O'Shaughnessy
£9,778 British Skin Foundation (BSF)
01-08-2025 - 31-07-2026
bullet iconUnderstanding the epidermal functions of JAK/STAT signalling in atopic dermatitis
Ryan O'Shaughnessy and Edel O'Toole
£80,839 British Skin Foundation (BSF)
01-12-2023 - 30-11-2025

bullet iconBSID Undergraduate Research Experience in Summer 2024
Ryan O'Shaughnessy
£2,000 British Skin Foundation (BSF)
08-07-2024 - 07-09-2024
bullet iconPhosphoproteomic identification of key AKT kinases and AKT targets for prevention and treatment of Squamous Cell Carcinoma - consumables only
Ryan O'Shaughnessy and Catherine Harwood
£9,962 British Skin Foundation (BSF)
04-02-2021 - 03-02-2022
bullet iconAKT1-dependent control of barrier function and inflammation in eczema
Ryan O'Shaughnessy and Edel O'Toole
£236,971 Barts and the London Charity
01-07-2020 - 31-12-2024
bullet iconUnderstanding the Regulation of Epidermal Differentiation Genes by Filaggrin in Eczema
Ryan O'Shaughnessy and Edel O'Toole
£273,043 Medical Research Council
17-02-2020 - 30-04-2023
bullet iconUnderstanding mechanisms of AKT expression and activity during skin cancer progression
Ryan O'Shaughnessy
£211,574 Barts and the London Charity
01-02-2018 - 20-01-2025