Dr Patrick Pallier
Lecturer in Neuroscience
Barts and The London School of Medicine and Dentistry
Queen Mary University of London, The Blizard Institute
Queen Mary University of London, The Blizard Institute
Research
Neuroprotection, Neurorepair, Spinal cord injury, Traumatic brain injury, Ageing and neurodegeneration, Development of new drugs
Interests
I use 2D cell cultures (cortical cells; dorsal root ganglion cells) to test pro-regenerative and neuroprotective compounds, and to study white matter and how to protect it during ageing or after trauma (oligodendrocyte-enriched cultures). I have also just started a new project to study axonopathy in various models of diseases, whereby neurospheres are grown in a microfluidic chamber to funnel the growth of a bundle of axons into a microchannel.Publications
Publications of specific relevance to Predictive in vitro Models2022
Perez-Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT and Hobbs AJ (2022). C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrity. Frontiers Frontiers in Molecular Neuroscience vol. 15, 10.3389/fnmol.2022.991112Thau-Zuchman O, Pallier PN, Savelkoul PJM, Kuipers AAM, Verkuyl JM and Michael-Titus AT (2022). High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slices. Frontiers Frontiers in Neuroscience vol. 16, 10.3389/fnins.2022.926023Pallier PN, Ferrara M, Romagnolo F, Ferretti MT, Soreq H and Cerase A (2022). Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventions. Elsevier Progress in Neurobiology vol. 219, 10.1016/j.pneurobio.2022.1023532020
Gaviria M, Celeghin A, Michael-Titus AT and Pallier PN (2020). Editorial: Brain Plasticity and Contribution of the Emotional Brain to Neural Remodelling After Injury. Frontiers Media Frontiers in Neurology vol. 11, 606271-606271. 10.3389/fneur.2020.606271Vrettos EI, Valverde IE, Mascarin A, Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B, Bekas N, Grob NM, Stylos EΚ, Shaye H, Del Borgo M, Aguilar M, Magnani F, Syed N, Crook T, Waqif E, Ghazaly E, Cherezov V, Widdop RE, Luchinat C, Michael‐Titus AT, Mindt TL and Tzakos AG (2020). Cover Feature: Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity (Chem. Eur. J. 47/2020). Wiley Chemistry - a European Journal vol. 26, (47) 10646-10646. 10.1002/chem.202003569Vrettos EI, Valverde IE, Mascarin A, Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B, Bekas N, Grob NM, Stylos E, Shaye H, Del Borgo M, Aguilar M-I, Magnani F, Syed N, Crook T, Waqif E, Ghazaly E, Cherezov V, Widdop RE, Luchinat C, Michael-Titus AT, Mindt TL and Tzakos A (2020). Single peptide backbone surrogate mutations to regulate angiotensin GPCR subtype selectivity. Wiley Chemistry: a European Journal 10.1002/chem.2020009242019
Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV, Dalli J, Tremoleda JL and Michael-Titus AT (2019). A Single Injection of Docosahexaenoic Acid Induces a Pro-Resolving Lipid Mediator Profile in the Injured Tissue and a Long-Lasting Reduction in Neurological Deficit after Traumatic Brain Injury in Mice. Mary Ann Liebert Journal of Neurotrauma vol. 37, (1) 66-79. 10.1089/neu.2019.64202018
BO XUENONG, GUSHCHINA S, PRYCE G, YIP P, WU D, PALLIER P, GIOVANNONI G and BAKER D (2018). Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss. Wiley Glia vol. 66, (10) 2108-2125. 10.1002/glia.234642016
Thau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL and Michael-Titus AT (2016). A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury. Brain Injury vol. 30, (5-6) 679-679. 2015
Pallier PN, Poddighe L, Zbarsky V, Kostusiak M, Choudhury R, Hart T, Burguillos MA, Musbahi O, Groenendijk M, Sijben JW, deWilde MC, Quartu M, Priestley JV and Michael-Titus AT (2015). A nutrient combination designed to enhance synapse formation and function improves outcome in experimental spinal cord injury. Elsevier Neurobiology of Disease vol. 82, 504-515. 10.1016/j.nbd.2015.09.0072014
Ward RE, Huang W, Kostusiak M, Pallier PN, Michael-Titus AT and Priestley JV (2014). A characterization of white matter pathology following spinal cord compression injury in the rat. Neuroscience vol. 260, 227-239. 10.1016/j.neuroscience.2013.12.0242009
Pallier PN and Morton AJ (2009). Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease. Brain Res vol. 1279, 90-98. 10.1016/j.brainres.2009.03.072Pallier PN, Drew CJG and Morton AJ (2009). The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function. Brain Res Bull vol. 78, (6) 347-355. 10.1016/j.brainresbull.2008.10.0072007
Pallier PN, Maywood ES, Zheng Z, Chesham JE, Inyushkin AN, Dyball R, Hastings MH and Morton AJ (2007). Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. J Neurosci vol. 27, (29) 7869-7878. 10.1523/JNEUROSCI.0649-07.2007Wood NI, Pallier PN, Wanderer J and Morton AJ (2007). Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice. Neurobiol Dis vol. 25, (2) 342-353. 10.1016/j.nbd.2006.09.0152004
Schrijver NCA, Pallier PN, Brown VJ and Würbel H (2004). Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats. Behav Brain Res vol. 152, (2) 307-314. 10.1016/j.bbr.2003.10.016Schrijver NCA, Pallier PN, Brown VJ and Wurbel H (2004). Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats. Behav Brain Res vol. 152, (2) 307-314. 10.1016/j.bbr.2003.10.0061997
Bamshad M, Karom M, Pallier P and Albers HE (1997). Role of the central amygdala in social communication in Syrian hamsters (Mesocricetus auratus). Brain Res vol. 744, (1) 15-22. 10.1016/s0006-8993(96)01061-x