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Dr Patrick Pallier

Patrick Pallier

Lecturer in Neuroscience

Barts and The London School of Medicine and Dentistry
Queen Mary University of London, The Blizard Institute
+44 (0)20 7882 2284

www.qmul.ac.uk/blizard/staff/centre-for-neuroscience-surgery-and-trauma/staff...

Research

Neuroprotection, Neurorepair, Spinal cord injury, Traumatic brain injury, Ageing and neurodegeneration, Development of new drugs

Interests

I use 2D cell cultures (cortical cells; dorsal root ganglion cells) to test pro-regenerative and neuroprotective compounds, and to study white matter and how to protect it during ageing or after trauma (oligodendrocyte-enriched cultures). I have also just started a new project to study axonopathy in various models of diseases, whereby neurospheres are grown in a microfluidic chamber to funnel the growth of a bundle of axons into a microchannel.

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Vrettos EI, Valverde IE, Mascarin A, Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B, Bekas N, Grob NM, Stylos E, Shaye H, Del Borgo M, Aguilar M-I, Magnani F, Syed N, Crook T, Waqif E, Ghazaly E, Cherezov V, Widdop RE, Luchinat C, Michael-Titus AT, Mindt TL and Tzakos A (2020). Single peptide backbone surrogate mutations to regulate angiotensin GPCR subtype selectivity. Wiley  Chemistry: a European Journal  10.1002/chem.202000924
Thau-Zuchman O, Ingram R, Harvey GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV, Dalli J, Tremoleda JL and Michael-Titus AT (2020). A single injection of docosahexaenoic acid induces a pro-resolving lipid mediator profile in the injured tissue and a long-lasting reduction in neurological deficit after traumatic brain injury in mice. Journal of Neurotrauma  vol. 37, (1) 66-79. 10.1089/neu.2019.6420

2018

BO XUENONG, GUSHCHINA S, PRYCE G, YIP P, WU D, PALLIER P, GIOVANNONI G and BAKER D (2018). Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal loss. Wiley  Glia  vol. 66, (10) 2108-2125. 10.1002/glia.23464

2016

Thau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL and Michael-Titus AT (2016). A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injury. Brain Injury  vol. 30, (5-6) 679-679.

2015

Pallier PN, Poddighe L, Zbarsky V, Kostusiak M, Choudhury R, Hart T, Burguillos MA, Musbahi O, Groenendijk M, Sijben JW, deWilde MC, Quartu M, Priestley JV and Michael-Titus AT (2015). A nutrient combination designed to enhance synapse formation and function improves outcome in experimental spinal cord injury. Neurobiology of Disease  vol. 82, 504-515. 10.1016/j.nbd.2015.09.007

2014

Ward RE, Huang W, Kostusiak M, Pallier PN, Michael-Titus AT and Priestley JV (2014). A characterization of white matter pathology following spinal cord compression injury in the rat. Neuroscience  vol. 260, 227-239. 10.1016/j.neuroscience.2013.12.024

2009

Pallier PN and Morton AJ (2009). Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease. Brain Res  vol. 1279, 90-98. 10.1016/j.brainres.2009.03.072
Pallier PN, Drew CJG and Morton AJ (2009). The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function. Brain Res Bull  vol. 78, (6) 347-355. 10.1016/j.brainresbull.2008.10.007

2007

Pallier PN, Maywood ES, Zheng Z, Chesham JE, Inyushkin AN, Dyball R, Hastings MH and Morton AJ (2007). Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease. J Neurosci  vol. 27, (29) 7869-7878. 10.1523/JNEUROSCI.0649-07.2007
Wood NI, Pallier PN, Wanderer J and Morton AJ (2007). Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice. Neurobiol Dis  vol. 25, (2) 342-353. 10.1016/j.nbd.2006.09.015

2004

Schrijver NCA, Pallier PN, Brown VJ and Würbel H (2004). Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats. Behav Brain Res  vol. 152, (2) 307-314. 10.1016/j.bbr.2003.10.016
Schrijver NCA, Pallier PN, Brown VJ and Wurbel H (2004). Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats. Behav Brain Res  vol. 152, (2) 307-314. 10.1016/j.bbr.2003.10.006

1997

Bamshad M, Karom M, Pallier P and Albers HE (1997). Role of the central amygdala in social communication in Syrian hamsters (Mesocricetus auratus). Brain Res  vol. 744, (1) 15-22. 10.1016/s0006-8993(96)01061-x