Dr Patrick Pallier
Lecturer in Neuroscience
The Blizard Institute, Barts and The London School of Medicine and Dentistry
Queen Mary University of London
Queen Mary University of London
Research
Neuroprotection, Neurorepair, Spinal cord injury, Traumatic brain injury, Ageing and neurodegeneration, Development of new drugs
Interests
I use 2D cell cultures (cortical cells; dorsal root ganglion cells) to test pro-regenerative and neuroprotective compounds, and to study white matter and how to protect it during ageing or after trauma (oligodendrocyte-enriched cultures). I have also just started a new project to study axonopathy in various models of diseases, whereby neurospheres are grown in a microfluidic chamber to funnel the growth of a bundle of axons into a microchannel.Publications
2025
Impact of galanin receptors 2 and 3 double-knockout on neuroinflammation and functional recovery following traumatic brain injuryBrunner SM, Gaisbauer S, Pallier PN, Yip PK, Ramspacher A, Leitner J, Sternberg F, Erhardt-Kreutzer C et al.
Peptides, Elsevier vol. 191
22-05-2025
The p3 peptides (Aβ17-40/42) rapidly form amyloid fibrils that cross-seed with full-length AβTian Y, Torres-Flores AP, Shang Q, Zhang H, Khursheed A, Tahirbegi B, Pallier PN, Viles JH
Nature Communications, Springer Nature vol. 16 (1)
27-02-2025
Hypoxic Neuroinflammation in the Pathogenesis of Multiple SclerosisHollingworth BYA, Pallier PN, Jenkins SI
Brain Sciences, Mdpi vol. 15 (3)
26-02-2025
2022
C-type natriuretic peptide preserves central neurological function by maintaining blood-brain barrier integrityPerez Ternero C, Pallier PN, Tremoleda JL, Delogu A, Fernandes C, Michael-Titus AT, Hobbs AJ
Frontiers in Molecular Neuroscience, Frontiers vol. 15, 991112-991112.
04-10-2022
High phenylalanine concentrations induce demyelination and microglial activation in mouse cerebellar organotypic slicesThau-Zuchman O, Pallier PN, Savelkoul PJM, Kuipers AAM, Verkuyl JM, Michael-Titus AT
Frontiers in Neuroscience, Frontiers vol. 16
29-09-2022
Chromosomal and environmental contributions to sex differences in the vulnerability to neurological and neuropsychiatric disorders: Implications for therapeutic interventionsPallier PN, Ferrara M, Romagnolo F, Ferretti MT, Soreq H, Cerase A
Progress in Neurobiology, Elsevier vol. 219
12-09-2022
2020
Editorial: Brain Plasticity and Contribution of the Emotional Brain to Neural Remodelling After InjuryGaviria M, Celeghin A, Michael-Titus AT, Pallier PN
Frontiers in Neurology, Frontiers Media vol. 11, 606271-606271.
26-10-2020
Cover Feature: Single Peptide Backbone Surrogate Mutations to Regulate Angiotensin GPCR Subtype Selectivity (Chem. Eur. J. 47/2020)Vrettos EI, Valverde IE, Mascarin A, Cerofolini L, Fragai M, Parigi G, Hirmiz B, Bekas N et al.
Chemistry - a European Journal, Wiley vol. 26 (47), 10646-10646.
07-08-2020
Single peptide backbone surrogate mutations to regulate angiotensin GPCR subtype selectivityVrettos EI, Valverde IE, Mascarin A, Pallier PN, Cerofolini L, Fragai M, Parigi G, Hirmiz B et al.
Chemistry: a European Journal, Wiley
21-07-2020
2018
Increased expression of colony‐stimulating factor‐1 in mouse spinal cord with experimental autoimmune encephalomyelitis correlates with microglial activation and neuronal lossBO XUENONG, GUSHCHINA S, PRYCE G, YIP P, WU D, PALLIER P, GIOVANNONI G, BAKER D
Glia, Wiley vol. 66 (10), 2108-2125.
25-08-2018
2016
A specific multi-nutrient intervention, designed to enhance synapse formation and function, improves functional outcome following traumatic brain injuryThau-Zuchman O, Pallier PN, Davies M, Groenendijk M, de Wilde MC, Tremoleda JL, Michael-Titus AT
Brain Injury vol. 30 (5-6), 679-679.
01-01-2016
2015
A nutrient combination designed to enhance synapse formation and function improves outcome in experimental spinal cord injuryPallier PN, Poddighe L, Zbarsky V, Kostusiak M, Choudhury R, Hart T, Burguillos MA, Musbahi O et al.
Neurobiology of Disease, Elsevier vol. 82, 504-515.
24-09-2015
2014
A characterization of white matter pathology following spinal cord compression injury in the rat.Ward RE, Huang W, Kostusiak M, Pallier PN, Michael-Titus AT, Priestley JV
Neuroscience vol. 260, 227-239.
28-02-2014
2009
Management of sleep/wake cycles improves cognitive function in a transgenic mouse model of Huntington's disease.Pallier PN, Morton AJ
Brain Res vol. 1279, 90-98.
07-07-2009
The detection and measurement of locomotor deficits in a transgenic mouse model of Huntington's disease are task- and protocol-dependent: influence of non-motor factors on locomotor function.Pallier PN, Drew CJG, Morton AJ
Brain Res Bull vol. 78 (6), 347-355.
30-03-2009
2007
Pharmacological imposition of sleep slows cognitive decline and reverses dysregulation of circadian gene expression in a transgenic mouse model of Huntington's disease.Pallier PN, Maywood ES, Zheng Z, Chesham JE, Inyushkin AN, Dyball R, Hastings MH, Morton AJ
J Neurosci vol. 27 (29), 7869-7878.
18-07-2007
Systemic administration of Congo red does not improve motor or cognitive function in R6/2 mice.Wood NI, Pallier PN, Wanderer J, Morton AJ
Neurobiol Dis vol. 25 (2), 342-353.
01-02-2007
2004
Double dissociation of social and environmental stimulation on spatial learning and reversal learning in rats.Schrijver NCA, Pallier PN, Brown VJ, Würbel H
Behav Brain Res vol. 152 (2), 307-314.
09-07-2004
Double dissociation of social and environmental stimulation on spatial learning and reversal learning in ratsSchrijver NCA, Pallier PN
Behav Brain Res vol. 152 (2), 307-314.
09-07-2004
1997
Role of the central amygdala in social communication in Syrian hamsters (Mesocricetus auratus).Bamshad M, Karom M, Pallier P, Albers HE
Brain Res vol. 744 (1), 15-22.
02-01-1997
A single injection of docosahexaenoic acid induces a pro-resolving lipid mediator profile in the injured tissue and a long-lasting reduction in neurological deficit after traumatic brain injury in miceThau Zuchman O, Ingram R, HARVEY GG, Cooke T, Palmas F, Pallier PN, Brook J, Priestley JV et al.
Journal of Neurotrauma, Mary Ann Liebert