Publications

Publications of specific relevance to Predictive in vitro Models
2020

Forte D, García-Fernández M, Sánchez-Aguilera A, Stavropoulou V, Fielding C, Martín-Pérez D, López JA, Costa ASH, Tronci L, Nikitopoulou E, Barber M,
Gallipoli P, Marando L, Fernández de Castillejo CL, Tzankov A, Dietmann S, Cavo M, Catani L, Curti A, Vázquez J, Frezza C, Huntly BJ, Schwaller J and Méndez-Ferrer S (2020).
Bone Marrow Mesenchymal Stem Cells Support Acute Myeloid Leukemia Bioenergetics and Enhance Antioxidant Defense and Escape from Chemotherapy. Cell Metabolism vol. 32, (5) 829-843.e9.
10.1016/j.cmet.2020.09.001
Castelli R, Bergamaschini L, Teatini T, Cilumbriello L, Schiavon R,
Gallipoli P and Deliliers GL (2020).
Does Outcome/Survival of Patients With Myelodysplastic Syndromes Should Be Predicted by Reduced Levels of ADAMTS-13? Results From a Pilot Study. Clinical Lymphoma, Myeloma and Leukemia vol. 20, (8) e461-e467.
10.1016/j.clml.2019.12.016
Horne GA, Stobo J, Kelly C, Mukhopadhyay A, Latif AL, Dixon-Hughes J, McMahon L, Cony-Makhoul P, Byrne J, Smith G, Koschmieder S, BrÜmmendorf TH, Schafhausen P,
Gallipoli P, Thomson F, Cong W, Clark RE, Milojkovic D, Helgason GV, Foroni L, Nicolini FE, Holyoake TL and Copland M (2020).
A randomised phase II trial of hydroxychloroquine and imatinib versus imatinib alone for patients with chronic myeloid leukaemia in major cytogenetic response with residual disease. Leukemia vol. 34, (7) 1775-1786.
10.1038/s41375-019-0700-92019

Sasca D, Yun H, Giotopoulos G, Szybinski J, Evan T, Wilson NK, Gerstung M,
Gallipoli P, Green AR, Hills R, Russell N, Osborne CS, Papaemmanuil E, Göttgens B, Campbell P and Huntly BJP (2019).
Cohesin-dependent regulation of gene expression during differentiation is lost in cohesin-mutated myeloid malignancies. Blood vol. 134, (24) 2195-2208.
10.1182/blood.2019001553
Claudiani S, Metelli S, Kamvar R, Szydlo R, Khan A, Byrne J,
Gallipoli P, Bulley SJ, Horne GA, Rothwell K, Copland M, Clark RE, Khorashad JS, Foroni L, Milojkovic D and Apperley JF (2019).
Introducing a Predictive Score for Successful Treatment Free Remission in Chronic Myeloid Leukemia (CML). Blood vol. 134, (1)
10.1182/blood-2019-131500
Basheer F, Giotopoulos G, Meduri E, Yun H, Mazan M, Sasca D,
Gallipoli P, Marando L, Gozdecka M, Asby R, Sheppard O, Dudek M, Bullinger L, Döhner H, Dillon R, Freeman S, Ottmann O, Burnett A, Russell N, Papaemmanuil E, Hills R, Campbell P, Vassiliou GS and Huntly BJP (2019).
Contrasting requirements during disease evolution identify EZH2 as a therapeutic target in AML. Journal of Experimental Medicine vol. 216, (4) 966-981.
10.1084/jem.20181276
Castelli R,
Gallipoli P, Schiavon R, Teatini T, Deliliers GL and Bergamaschini L (2019).
Increased risk of heparin induced thrombocytopenia and thrombosis in patients with essential thrombocythemia carrying the homozygous JAK2 V617F mutation. Journal of Thrombosis and Thrombolysis vol. 47, (1) 155-156.
10.1007/s11239-018-1773-42018

Tzelepis K, De Braekeleer E, Aspris D, Barbieri I, Vijayabaskar MS, Liu WH, Gozdecka M, Metzakopian E, Toop HD, Dudek M, Robson SC, Hermida-Prado F, Yang YH, Babaei-Jadidi R, Garyfallos DA, Ponstingl H, Dias JML,
Gallipoli P, Seiler M, Buonamici S, Vick B, Bannister AJ, Rad R, Prinjha RK, Marioni JC, Huntly B, Batson J, Morris JC, Pina C and Bradley A (2018).
SRPK1 maintains acute myeloid leukemia through effects on isoform usage of epigenetic regulators including BRD4. Nature Communications vol. 9, (1)
10.1038/s41467-018-07620-0
Gallipoli P, Giotopoulos G, Tzelepis K, Costa ASH, Vohra S, Medina-Perez P, Basheer F, Marando L, Lisio LD, Dias JML, Yun H, Sasca D, Horton SJ, Vassiliou G, Frezza C and Huntly BJP (2018).
Glutaminolysis is a metabolic dependency in FLT3 ITD acute myeloid leukemia unmasked by FLT3 tyrosine kinase inhibition. Blood vol. 131, (15) 1639-1653.
10.1182/blood-2017-12-820035
Castelli R,
Gallipoli P, Schiavon R, Teatini T, Deliliers GL and Bergamaschini L (2018).
High prevalence of heparin induced thrombocytopenia with thrombosis among patients with essential thrombocytemia carrying V617F mutation. Journal of Thrombosis and Thrombolysis vol. 45, (1) 106-113.
10.1007/s11239-017-1566-12016

Tarafdar A, Hopcroft LE,
Gallipoli P, Pellicano F, Cassels J, Hair A, Korfi K, Jørgensen HG, Vetrie D, Holyoake TL and Michie AM (2016).
CML cells actively evade host immune surveillance through cytokine-mediated downregulation of MHC-II expression. Blood 10.1182/blood-2016-09-742049
Tzelepis K, Koike-Yusa H, De Braekeleer E, Li Y, Metzakopian E, Dovey OM, Mupo A, Grinkevich V, Li M, Mazan M, Gozdecka M, Ohnishi S, Cooper J, Patel M, McKerrell T, Chen B, Domingues AF,
Gallipoli P, Teichmann S, Ponstingl H, McDermott U, Saez-Rodriguez J, Huntly BJP, Iorio F, Pina C, Vassiliou GS and Yusa K (2016).
A CRISPR Dropout Screen Identifies Genetic Vulnerabilities and Therapeutic Targets in Acute Myeloid Leukemia. Cell Reports vol. 17, (4) 1193-1205.
10.1016/j.celrep.2016.09.079
Scott MT, Korfi K, Saffrey P, Hopcroft LE, Kinstrie R, Pellicano F, Guenther C,
Gallipoli P, Cruz M, Dunn K, Jorgensen HG, Cassels JE, Hamilton A, Crossan A, Sinclair A, Holyoake TL and Vetrie D (2016).
Epigenetic Reprogramming Sensitizes CML Stem Cells to Combined EZH2 and Tyrosine Kinase Inhibition. American Association For Cancer Research Cancer Discovery vol. 6, (11) 1248-1257.
10.1158/2159-8290.CD-16-0263
Gidaro A, Deliliers GL,
Gallipoli P, Arquati M, Wu MA and Castelli R (2016).
Laboratory and clinical risk assessment to treat myelodysplatic syndromes. Clinical Chemistry and Laboratory Medicine vol. 54, (9) 1411-1426.
10.1515/cclm-2015-0789
Giotopoulos G, Chan WI, Horton SJ, Ruau D,
Gallipoli P, Fowler A, Crawley C, Papaemmanuil E, Campbell PJ, Göttgens B, Van Deursen JM, Cole PA and Huntly BJP (2016).
The epigenetic regulators CBP and p300 facilitate leukemogenesis and represent therapeutic targets in acute myeloid leukemia. Oncogene vol. 35, (3) 279-289.
10.1038/onc.2015.922015

Castelli R, Pantaleo G,
Gallipoli P, Gidaro A, Arquati M, Wu MA and Lambertenghi Deliliers G (2015).
Salvage therapy with bortezomib and dexamethasone in elderly patients with relapsed/refractory multiple myeloma. Anti-Cancer Drugs vol. 26, (10) 1078-1082.
10.1097/CAD.0000000000000285
Giotopoulos G, van der Weyden L, Osaki H, Rust AG,
Gallipoli P, Meduri E, Horton SJ, Chan WI, Foster D, Prinjha RK, Pimanda JE, Tenen DG, Vassiliou GS, Koschmieder S, Adams DJ and Huntly BJP (2015).
A novel mouse model identifies cooperating mutations and therapeutic targets critical for chronic myeloid leukemia progression. Journal of Experimental Medicine vol. 212, (10) 1551-1569.
10.1084/jem.20141661
Gallipoli P, Giotopoulos G and Huntly BJP (2015).
Epigenetic regulators as promising therapeutic targets in acute myeloid leukemia. Therapeutic Advances in Hematology vol. 6, (3) 103-119.
10.1177/2040620715577614
Hopcroft LEM, Calderhead B,
Gallipoli P, Holyoake TL and Girolami MA (2015).
Bayesian inference for model selection: An application to aberrant signalling pathways in chronic myeloid leukaemia. Systems Genetics: Linking Genotypes and Phenotypes 10.1017/CBO9781139012751.0092014
Gallipoli P, Cook A, Rhodes S, Hopcroft L, Wheadon H, Whetton AD, Jørgensen HG, Bhatia R and Holyoake TL (2014).
JAK2/STAT5 inhibition by nilotinib with ruxolitinib contributes to the elimination of CML CD34+ cells in vitro and in vivo. Blood vol. 124, (9) 1492-1501.
10.1182/blood-2013-12-545640
Colombo R,
Gallipoli P and Castelli R (2014).
Thrombosis and hemostatic abnormalities in hematological malignancies. Clinical Lymphoma, Myeloma and Leukemia vol. 14, (6) 441-450.
10.1016/j.clml.2014.05.003
Castelli R, Deliliers GL, Colombo R, Moreo G,
Gallipoli P and Pantaleo G (2014).
Biosimilar epoetin in elderly patients with low-risk myelodysplastic syndromes improves anemia, quality of life, and brain function. Annals of Hematology vol. 93, (9) 1523-1529.
10.1007/s00277-014-2070-82013
Gallipoli P, Stobo J, Heaney N, Nicolini FE, Clark R, Wilson G, Tighe J, Mclintock L, Hughes T, Michor F, Paul J, Drummond M and Holyoake TL (2013).
Safety and efficacy of pulsed imatinib with or without G-CSF versus continuous imatinib in chronic phase chronic myeloid leukaemia patients at 5 years follow-up. British Journal of Haematology vol. 163, (5) 674-676.
10.1111/bjh.12532
Giotopoulos G, Chan W-I, Ruau D,
Gallipoli P, Fowler A, Göttgens B, Van Deursen J, Cole P and Huntly B (2013).
The Epigenetic Regulators CBP and p300 Facilitate Leukemogenesis and Represent Therapeutic Targets In Acute Myeloid Leukemia (AML). Blood vol. 122, (21) 3732-3732.
10.1182/blood.v122.21.3732.3732
Chen M,
Gallipoli P, Degeer D, Sloma I, Forrest DL, Chan M, Lai D, Jorgensen H, Ringrose A, Wang HM, Lambie K, Nakamoto H, Saw KM, Turhan A, Arlinghaus R, Paul J, Stobo J, Barnett MJ, Eaves A, Eaves CJ, Holyoake TL and Jiang X (2013).
Targeting primitive chronic myeloid leukemia cells by effective inhibition of a new AHI-1-BCR-ABL-JAK2 complex. Journal of The National Cancer Institute vol. 105, (6) 405-423.
10.1093/jnci/djt006
Mcilwaine L, Parker A, Sandilands G,
Gallipoli P and Leach M (2013).
Neutrophil-specific granule deficiency. British Journal of Haematology vol. 160, (6)
10.1111/bjh.12207
Gallipoli P, Pellicano F, Morrison H, Laidlaw K, Allan EK, Bhatia R, Copland M, Jørgensen HG and Holyoake TL (2013).
Autocrine TNF-α production supports CML stem and progenitor cell survival and enhances their proliferation. Blood vol. 122, (19) 3335-3339.
10.1182/blood-2013-02-4856072012

Shah M,
Gallipoli P, Lyons J, Holyoake T and Jørgensen H (2012).
Effects of the novel aurora kinase/JAK inhibitor, AT9283 and imatinib on Philadelphia positive cells in vitro. Blood Cells, Molecules, and Diseases vol. 48, (3) 199-201.
10.1016/j.bcmd.2012.01.0052011
Gallipoli P, Abraham SA and Holyoake TL (2011).
Hurdles Toward a Cure for CML: The CML Stem Cell. Hematology/Oncology Clinics of North America vol. 25, (5) 951-966.
10.1016/j.hoc.2011.09.001
Gallipoli P, Shepherd P, Irvine D, Drummond M and Holyoake T (2011).
Restricted access to second generation tyrosine kinase inhibitors in the UK could result in suboptimal treatment for almost half of chronic myeloid leukaemia patients: Results from a West of Scotland and Lothian population study. British Journal of Haematology vol. 155, (1) 128-130.
10.1111/j.1365-2141.2011.08653.x2010

DeGeer D,
Gallipoli P, Chen M, Sloma I, Jorgensen H, Forrest D, Lambie K, Nakamoto H, Saw KM, Chan M, Newmarch K, Zhou L, Turhan AG, Arlinghaus RB, Eaves AC, Eaves CJ, Holyoake TL and Jiang X (2010).
Combined Targeting of BCR-ABL and JAK2 with ABL and JAK2 Inhibitors Is Effective Against CML Patients' Leukemic Stem/Progenitor Cells. Blood vol. 116, (21) 3404-3404.
10.1182/blood.v116.21.3404.3404
Hamilton A,
Gallipoli P, Nicholson E and Holyoake TL (2010).
Targeted therapy in haematological malignancies. Journal of Pathology vol. 220, (4) 404-418.
10.1002/path.26692009
Gallipoli P, Clark A and Leach M (2009).
The evolving management of a rare lymphoproliferative disorder-T-cell prolymphocytic leukemia. American Journal of Hematology vol. 84, (11) 750-753.
10.1002/ajh.21498
Gallipoli P (2009).
Pseudotumour cerebri as a manageable side effect of prolonged all-trans retinoic acid therapy in an adult patient with acute promyelocytic leukaemia. European Journal of Haematology vol. 82, (3) 242-243.
10.1111/j.1600-0609.2008.01185.x2007
2006

Finelli C,
Gallipoli P, Celentano E, Cacace G, Saldalamacchia G, De Caprio C, Contaldo F and Pasanisi F (2006).
Assessment of physical activity in an outpatient obesity clinic in southern Italy: Results from a standardized questionnaire. Nutrition, Metabolism and Cardiovascular Diseases vol. 16, (3) 168-173.
10.1016/j.numecd.2005.05.0022002
1992

Clark JA, Deutch AY,
Gallipoli PZ and Amara SG (1992).
Functional expression and CNS distribution of a β-alanine-sensitive neuronal GABA transporter. Neuron vol. 9, (2) 337-348.
10.1016/0896-6273(92)90172-A