Dr Neil McCarthy
PhDMRC Career Development Fellow; Lecturer in Immunology
CPM Theme lead - Infectious Disease & Inflammation Models
Centre for Immunobiology, The Blizard Institute
School of Medicine & Dentistry, Queen Mary University of London
+44 (0)20 7882 2326School of Medicine & Dentistry, Queen Mary University of London
n.e.mccarthy@qmul.ac.uk
www.qmul.ac.uk/blizard/all-staff/profiles/neil-mccarthy.html
Research
Intestine, Inflammation, Candida, Fungus, Crohn's disease, Ulcerative colitis
Interests
The McCarthy lab studies host–pathogen interactions at mucosal surfaces, with a particular focus on γδ T-cells and their role in gut barrier protection against microbial infection and inflammation. The ultimate aim of this work is to understand how γδ T-cell function becomes dysregulated in inflammatory bowel disease (IBD) and could potentially be restored by novel agonist / antagonist immunotherapies.Publications
Publications of specific relevance to Predictive in vitro Models2021
Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Stagg AJ, Lindsay JO and Whelan K (2021). Prebiotic fructans have greater impact on luminal microbiology and CD3+ T cells in healthy siblings than patients with Crohn's disease: A pilot study investigating the potential for primary prevention of inflammatory bowel disease. Clinical Nutrition vol. 40, (8) 5009-5019. 10.1016/j.clnu.2021.05.033Park JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SC, Liou KCK, Lynn SE, Ng SS, Meng W, Lim SC, Leow MK-S, Richards AM, Pennington DJ, de Kleijn DPV, Sorokin V, Ho HH, McCarthy NE and Sze SK (2021). Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Atherosclerosis vol. 324, 58-68. 10.1016/j.atherosclerosis.2021.03.020Panoskaltsis N, McCarthy NE and Knight SC (2021). Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm. Cancer Immunol Immunother vol. 70, (4) 1155-1160. 10.1007/s00262-020-02702-9Panoskaltsis N, McCarthy NE, Stagg AJ, Mummery CJ, Husni M, Arebi N, Greenstein D, Price CL, Al-Hassi HO, Koutinas M, Mantalaris A and Knight SC (2021). Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm. Cancer Immunology, Immunotherapy vol. 70, (4) 1127-1142. 10.1007/s00262-020-02725-22020
McCarthy NE, Stagg AJ, Price CL, Mann ER, Gellatly NL, Al-Hassi HO, Knight SC and Panoskaltsis N (2020). Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells. Springer (Part of Springer Nature) Cancer Immunology Immunotherapy 10.1007/s00262-020-02723-4Tse SW, Tan CF, Park JE, Gnanasekaran J, Gupta N, Low JK, Yeoh KW, Chng WJ, Tay CY, McCarthy NE, Lim SK and Sze SK (2020). Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles. Cancers (Basel) vol. 12, (10) 10.3390/cancers12102917Ng SS, Park JE, Meng W, Chen CP, Kalaria RN, Mccarthy NE and Sze SK (2020). Pulsed SILAM Reveals in Vivo Dynamics of Murine Brain Protein Translation. Acs Omega vol. 5, (23) 13528-13540. 10.1021/acsomega.9b044392019
Gill US and McCarthy NE (2019). CD4 T cells in hepatitis B virus: You don't have to be cytotoxic to work here and help. Elsevier Journal of Hepatology 10.1016/j.jhep.2019.10.008Gupta N, Park JE, Tse W, Low JK, Kon OL, McCarthy N and Sze SK (2019). ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer. Impact Journals Oncotarget vol. 10, (57) 5970-5982. 10.18632/oncotarget.27235Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H, Levenez F, Pons N, Maziers N, Lomer MC, Ehrlich SD, Irving PM and Whelan K (2019). Effects of Low-FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial. Elsevier Gastroenterology 10.1053/j.gastro.2019.09.0242018
McCarthy NE and Eberl M (2018). Human γδ T-Cell Control of Mucosal Immunity and Inflammation. Frontiers Media S.a. Front Immunol vol. 9, 985-985. 10.3389/fimmu.2018.009852017
MCCARTHY NE, Tyler CJ, Lindsay JO, Stagg AJ, Moser B and Eberl M (2017). Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. American Association of Immunologists Journal of Immunology 10.4049/jimmunol.1700003Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, Macdonald TT, Lindsay JO and Stagg AJ (2017). Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease. Mucosal Immunology vol. 10, (1) 184-193. 10.1038/mi.2016.442016
Petty RD, McCarthy NE, Dieu RL and Kerr JR (2016). MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential diagnostic biomarkers in natural killer (NK) cells of patients with Chronic Fatigue Syndrome (CFS)/myalgic encephalomyelitis (ME). Plos One vol. 11, (3) 10.1371/journal.pone.01509042015
McCarthy NE, Hedin CR, Sanders TJ, Amon P, Hoti I, Ayada I, Baji V, Giles EM, Wildemann M, Bashir Z, Whelan K, Sanderson I, Lindsay JO and Stagg AJ (2015). Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease. American Society For Clinical Investigation Journal of Clinical Investigation vol. 125, (8) 3215-3225. 10.1172/JCI80840Brugha R, Mushtaq N, McCarthy NE, Stagg AJ and Grigg J (2015). Respiratory tract dendritic cells in paediatric asthma. Clin Exp Allergy vol. 45, (3) 624-631. 10.1111/cea.124572014
Sanders TJ, McCarthy NE, Giles EM, Davidson KLM, Haltalli MLR, Hazell S, Lindsay JO and Stagg AJ (2014). Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease. Gastroenterology vol. 146, (5) 10.1053/j.gastro.2014.01.057Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Taylor K, Prescott NJ, Murrells T, Stagg AJ, Whelan K and Lindsay JO (2014). Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings. Gut 10.1136/gutjnl-2013-3062262013
McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ, Whelan K, MacDonald TT, Lindsay JO and Stagg AJ (2013). Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells. J Immunol vol. 191, (5) 2752-2763. 10.4049/jimmunol.1202959Hedin C, McCarthy NE, Louis P, Farquharson F, McCartney S, Taylor K, Prescott N, Murrells T, Stagg AJ, Whelan K and Lindsay JO (2013). OC-017 A Discriminant Analysis Demonstrates that Siblings of Patients with Crohn’S Disease have a Distinct Microbiological and Immune Phenotype Compared with Healthy Controls: Insights into Disease Pathogenesis. Gut vol. 62, (Suppl 1) 10.1136/gutjnl-2013-304907.017McCarthy N, Hedin C, Bashir Z, Vossenkämper A, Giles E, Sanders T, Whelan K, MacDonald T, Lindsay J and Stagg A (2013). P066 Human intestinal Vδ2+ T-cells promote mucosal inflammation in Crohn's disease and are selectively ablated by azathioprine therapy. Journal of Crohn\'s and Colitis vol. 7, s35-s36. 10.1016/s1873-9946(13)60088-42012
Mann ER, McCarthy NE, Peake STC, Milestone AN, Al-Hassi HO, Bernardo D, Tee CT, Landy J, Pitcher MC, Cochrane SA, Hart AL, Stagg AJ and Knight SC (2012). Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease. Clin Exp Immunol vol. 170, (2) 122-130. 10.1111/j.1365-2249.2012.04649.xMann ER, Bernardo D, Al-Hassi HO, English NR, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart AL, Stagg AJ and Knight SC (2012). Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment. Inflamm Bowel Dis vol. 18, (7) 1275-1286. 10.1002/ibd.21893Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew CG, Sanderson J, Hart AL, Kamm MA, Knight SC, Forbes A, Stagg AJ, Lindsay JO and Whelan K (2012). Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota. Inflammatory Bowel Diseases vol. 18, (6) 1092-1100. 10.1002/ibd.218642011
Ng SC, Benjamin JL, McCarthy NE, Hedin CRH, Koutsoumpas A, Plamondon S, Price CL, Hart AL, Kamm MA, Forbes A, Knight SC, Lindsay JO, Whelan K and Stagg AJ (2011). Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease. Inflamm Bowel Dis vol. 17, (10) 2027-2037. 10.1002/ibd.21590Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Hart AL, Kamm MA, Sanderson JD, Knight SC, Forbes A, Stagg AJ, Whelan K and Lindsay JO (2011). Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease. Gut vol. 60, (7) 923-929. 10.1136/gut.2010.2320252008
Holden NJ, Bedford PA, McCarthy NE, Marks NA, Ind PW, Jowsey IR, Basketter DA and Knight SC (2008). Dendritic cells from control but not atopic donors respond to contact and respiratory sensitizer treatment in vitro with differential cytokine production and altered stimulatory capacity. Clin Exp Allergy vol. 38, (7) 1148-1159. 10.1111/j.1365-2222.2008.02997.x2007
McCarthy NE, Jones HA, Marks NA, Shiner RJ, Ind PW, Al-Hassi HO, English NR, Murray CM, Lambert JR, Knight SC and Stagg AJ (2007). Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma. Clin Exp Allergy vol. 37, (1) 72-82. 10.1111/j.1365-2222.2006.02631.xGrants
Human tissue-resident immunity to intestinal fungiMcCarthy NE
£153,432 Bart's Charity (30-09-2019 - 31-03-2023)
Investigating BTN function in inflammatory bowel diseaseMcCarthy NE
£316,434 ImCheck Therapeutics (01-02-2021 - 31-01-2023)
Fungal suppression by human gut Vdelta2 T-cells in mucosal immunity and inflammationMccarthy NE
£547,618 Medical Research Council (02-01-2018 - 01-01-2023)
Human colonic T-cell responses in Crohn's disease: modulation by phosphoantigen products of the gut microbiotaMcCarthy NE
£75,000 Crohn's in Childhood Research Association (CiCRA) (01-07-2015 - 30-06-2016)
Disrupting Vδ2T-cell function in the gut: a novel approach to therapy in early stage Crohn’s diseaseMcCarthy NE
£60,000 Crohn’s and Colitis UK (01-06-2013 - 01-06-2014)
Vedolizumab: assessing impact on α4β7+ unconventional T-cells and α4β7+ precursors of intestinal antigen presenting cellsMcCarthy NE
£129,000 Takeda Pharmaceuticals (2014 - 2017)
γδ T-cell polarisation of CD4+ T-cell responses: implications for Crohn's diseaseMcCarthy NE
£34,000 Wellcome Trust (2016 - 2016)