Dr Neil McCarthy

MRC Career Development Fellow; Lecturer in Immunology

Research

Interests

Publications of specific relevance to Predictive in vitro Models

Publications

2020

Ng SS, Park JE, Meng W, Chen CP, Kalaria RN, Mccarthy NE and Sze SK (2020). Pulsed SILAM Reveals in Vivo Dynamics of Murine Brain Protein Translation. Acs Omega  10.1021/acsomega.9b04439

2019

Gill US and McCarthy NE (2019). CD4 T cells in hepatitis B virus: You don't have to be cytotoxic to work here and help. Elsevier  Journal of Hepatology  10.1016/j.jhep.2019.10.008

Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H, Levenez F, Pons N, Maziers N, Lomer MC, Ehrlich SD, Irving PM and Whelan K (2019). Effects of Low-FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial. Elsevier  Gastroenterology  10.1053/j.gastro.2019.09.024

2018

McCarthy NE and Eberl M (2018). Human γδ T-Cell Control of Mucosal Immunity and Inflammation. Frontiers Media S.a.  Front Immunol  vol. 9, 985-985. 10.3389/fimmu.2018.00985

2017

Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, Macdonald TT, Lindsay JO and Stagg AJ (2017). Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease. Mucosal Immunology  vol. 10, (1) 184-193. 10.1038/mi.2016.44

2016

Petty RD, McCarthy NE, Le Dieu R and Kerr JR (2016). MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME). Plos One  vol. 11, (3) 10.1371/journal.pone.0150904

2015

McCarthy NE, Hedin CR, Sanders TJ, Amon P, Hoti I, Ayada I, Baji V, Giles EM, Wildemann M, Bashir Z, Whelan K, Sanderson I, Lindsay JO and Stagg AJ (2015). Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease. American Society For Clinical Investigation  Journal of Clinical Investigation  vol. 125, (8) 3215-3225. 10.1172/JCI80840

Brugha R, Mushtaq N, McCarthy NE, Stagg AJ and Grigg J (2015). Respiratory tract dendritic cells in paediatric asthma. Clin Exp Allergy  vol. 45, (3) 624-631. 10.1111/cea.12457

2014

Sanders TJ, McCarthy NE, Giles EM, Davidson KLM, Haltalli MLR, Hazell S, Lindsay JO and Stagg AJ (2014). Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease. Gastroenterology  vol. 146, (5) 10.1053/j.gastro.2014.01.057

Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Taylor K, Prescott NJ, Murrells T, Stagg AJ, Whelan K and Lindsay JO (2014). Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings. Gut  10.1136/gutjnl-2013-306226

2013

McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ, Whelan K, MacDonald TT, Lindsay JO and Stagg AJ (2013). Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells. J Immunol  vol. 191, (5) 2752-2763. 10.4049/jimmunol.1202959

2012

Mann ER, McCarthy NE, Peake STC, Milestone AN, Al-Hassi HO, Bernardo D, Tee CT, Landy J, Pitcher MC, Cochrane SA, Hart AL, Stagg AJ and Knight SC (2012). Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease. Clin Exp Immunol  vol. 170, (2) 122-130. 10.1111/j.1365-2249.2012.04649.x

Mann ER, Bernardo D, Al-Hassi HO, English NR, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart AL, Stagg AJ and Knight SC (2012). Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment. Inflamm Bowel Dis  vol. 18, (7) 1275-1286. 10.1002/ibd.21893

Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew CG, Sanderson J, Hart AL, Kamm MA, Knight SC, Forbes A, Stagg AJ, Lindsay JO and Whelan K (2012). Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota. Inflammatory Bowel Diseases  vol. 18, (6) 1092-1100. 10.1002/ibd.21864

2011

Ng SC, Benjamin JL, McCarthy NE, Hedin CRH, Koutsoumpas A, Plamondon S, Price CL, Hart AL, Kamm MA, Forbes A, Knight SC, Lindsay JO, Whelan K and Stagg AJ (2011). Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease. Inflamm Bowel Dis  vol. 17, (10) 2027-2037. 10.1002/ibd.21590

Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Hart AL, Kamm MA, Sanderson JD, Knight SC, Forbes A, Stagg AJ, Whelan K and Lindsay JO (2011). Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease. Gut  vol. 60, (7) 923-929. 10.1136/gut.2010.232025

2008

Holden NJ, Bedford PA, McCarthy NE, Marks NA, Ind PW, Jowsey IR, Basketter DA and Knight SC (2008). Dendritic cells from control but not atopic donors respond to contact and respiratory sensitizer treatment in vitro with differential cytokine production and altered stimulatory capacity. Clin Exp Allergy  vol. 38, (7) 1148-1159. 10.1111/j.1365-2222.2008.02997.x

2007

McCarthy NE, Jones HA, Marks NA, Shiner RJ, Ind PW, Al-Hassi HO, English NR, Murray CM, Lambert JR, Knight SC and Stagg AJ (2007). Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma. Clin Exp Allergy  vol. 37, (1) 72-82. 10.1111/j.1365-2222.2006.02631.x

Grants

Grants of specific relevance to Predictive in vitro Models

Fungal suppression by human gut Vdelta2 T-cells in mucosal immunity and inflammation
Mccarthy NE
£547,618 Medical Research Council (02-01-2018 - 01-01-2023)

Abstract

Vedolizumab: assessing impact on α4β7+ unconventional T-cells and α4β7+ precursors of intestinal antigen presenting cells
McCarthy NE
£129,000 Takeda Pharmaceuticals (2014 - 2017)

Abstract

γδ T-cell polarisation of CD4+ T-cell responses: implications for Crohn's disease
McCarthy NE
£34,000 Wellcome Trust (2016 - 2016)

Abstract

Human colonic T-cell responses in Crohn's disease: modulation by phosphoantigen products of the gut microbiota
McCarthy NE
£75,000 Crohn's in Childhood Research Association (CiCRA) (01-07-2015 - 30-06-2016)

Abstract

Disrupting Vδ2T-cell function in the gut: a novel approach to therapy in early stage Crohn’s disease
McCarthy NE
£60,000 Crohn’s and Colitis UK (01-06-2013 - 01-06-2014)

Abstract