Dr Neil McCarthy

Neil McCarthy
PhD

MRC Career Development Fellow; Senior Lecturer in Immunology
CPM Theme lead - Infectious Disease & Inflammation Models

Centre for Immunobiology, The Blizard Institute
Faculty of Medicine and Dentistry, Queen Mary University of London
www.qmul.ac.uk/blizard/all-staff/profiles/neil-mccarthy.html
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Research

Intestine, Inflammation, Candida, Fungus, Crohn's disease, Ulcerative colitis

Infectious Disease and Inflammation Models

Interests

The McCarthy lab studies host–pathogen interactions at mucosal surfaces, with a particular focus on γδ T-cells and their role in gut barrier protection against microbial infection and inflammation. The ultimate aim of this work is to understand how γδ T-cell function becomes dysregulated in inflammatory bowel disease (IBD) and could potentially be restored by novel agonist / antagonist immunotherapies.

Publications

Publications of specific relevance to Predictive in vitro Models

2024

Mathew L, Carlson S, Savage M, Pardieu C, Sze N, Munro C, Naglik J, Stagg A, Kok K, Lindsay JO and McCarthy N (2024). P145 Phagocyte responses to gut-derived C. albicans are modified in inflammatory bowel disease. Oxford University Press (Oup)  Journal of Crohn\'s and Colitis  vol. 18, (Supplement_1) i446-i446. 10.1093/ecco-jcc/jjad212.0275
Ruchti F, Tuor M, Mathew L, McCarthy NE and LeibundGut-Landmann S (2024). γδ T cells respond directly and selectively to the skin commensal yeast Malassezia for IL-17-dependent fungal control. Public Library of Science (Plos)  Plos Pathogens  vol. 20, (1) 10.1371/journal.ppat.1011668

2023

Kalailingam P, Mohd‐Kahliab K, Ngan SC, Iyappan R, Melekh E, Lu T, Zien GW, Sharma B, Guo T, MacNeil AJ, MacPherson RE, Tsiani EL, O'Leary DD, Lim KL, Su IH, Gao Y, Richards AM, Kalaria RN, Chen CP, McCarthy NE and Sze SK (2023). Immunotherapy targeting isoDGR‐protein damage extends lifespan in a mouse model of protein deamidation. Springer Nature  Embo Molecular Medicine  vol. 15, (12) 10.15252/emmm.202318526
Carlson SL, Mathew L, Savage M, Kok K, Lindsay JO, Munro CA and McCarthy NE (2023). Mucosal Immunity to Gut Fungi in Health and Inflammatory Bowel Disease. Mdpi  Journal of Fungi  vol. 9, (11) 10.3390/jof9111105
Vinaiphat A, Pazhanchamy K, JebaMercy G, Ngan SC, Leow MK-S, Ho HH, Gao Y-G, Lim KL, Richards AM, de Kleijn DPV, Chen CP, Kalaria RN, Liu J, O’Leary DD, McCarthy NE and Sze SK (2023). Endothelial Damage Arising From High Salt Hypertension Is Elucidated by Vascular Bed Systematic Profiling. Wolters Kluwer  Arteriosclerosis Thrombosis and Vascular Biology  vol. 43, (3) 427-442. 10.1161/atvbaha.122.318439

2022

Ngan S-FC, McCarthy NE and Sze SK (2022). pSILAC-Based Determination of Cellular Protein Sorting into Extracellular Vesicles. Springer Nature  10.1007/978-1-0716-2863-8_4
Mathew L, Savage M, Pardieu C, O’Brien M, Sze SK, Eberl M, Stagg A, Gasparetto M, Kok K, Lindsay J and McCarthy N (2022). OP37 Bacterial suppression of intestinal fungi via activation of human gut Vδ2+ T-cells. Oxford University Press (Oup)  Journal of Crohn\'s and Colitis  vol. 16, (Supplement_1) i043-i044. 10.1093/ecco-jcc/jjab232.036

2021

Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Stagg AJ, Lindsay JO and Whelan K (2021). Prebiotic fructans have greater impact on luminal microbiology and CD3+ T cells in healthy siblings than patients with Crohn's disease: A pilot study investigating the potential for primary prevention of inflammatory bowel disease. Elsevier  Clinical Nutrition  vol. 40, (8) 5009-5019. 10.1016/j.clnu.2021.05.033
Park JE, JebaMercy G, Pazhanchamy K, Guo X, Ngan SC, Liou KCK, Lynn SE, Ng SS, Meng W, Lim SC, Leow MK-S, Richards AM, Pennington DJ, de Kleijn DPV, Sorokin V, Ho HH, McCarthy NE and Sze SK (2021). Aging-induced isoDGR-modified fibronectin activates monocytic and endothelial cells to promote atherosclerosis. Elsevier  Atherosclerosis  vol. 324, 58-68. 10.1016/j.atherosclerosis.2021.03.020

2020

McCarthy NE, Stagg AJ, Price CL, Mann ER, Gellatly NL, Al-Hassi HO, Knight SC and Panoskaltsis N (2020). Patients with gastrointestinal irritability after TGN1412-induced cytokine storm displayed selective expansion of gut-homing αβ and γδT cells. Springer (Part of Springer Nature)  Cancer Immunology Immunotherapy  10.1007/s00262-020-02723-4
Tse SW, Tan CF, Park JE, Gnanasekaran J, Gupta N, Low JK, Yeoh KW, Chng WJ, Tay CY, McCarthy NE, Lim SK and Sze SK (2020). Microenvironmental Hypoxia Induces Dynamic Changes in Lung Cancer Synthesis and Secretion of Extracellular Vesicles. Mdpi  Cancers  vol. 12, (10) 10.3390/cancers12102917
Panoskaltsis N, McCarthy NE, Stagg AJ, Mummery CJ, Husni M, Arebi N, Greenstein D, Price CL, Al-Hassi HO, Koutinas M, Mantalaris A and Knight SC (2020). Immune reconstitution and clinical recovery following anti-CD28 antibody (TGN1412)-induced cytokine storm. Springer Nature  Cancer Immunology, Immunotherapy  vol. 70, (4) 1127-1142. 10.1007/s00262-020-02725-2
Panoskaltsis N, McCarthy NE and Knight SC (2020). Myelopoiesis of acute inflammation: lessons from TGN1412-induced cytokine storm. Springer Nature  Cancer Immunology, Immunotherapy  vol. 70, (4) 1155-1160. 10.1007/s00262-020-02702-9
Ng SS, Park JE, Meng W, Chen CP, Kalaria RN, McCarthy NE and Sze SK (2020). Pulsed SILAM Reveals In Vivo Dynamics of Murine Brain Protein Translation. American Chemical Society (Acs)  Acs Omega  vol. 5, (23) 13528-13540. 10.1021/acsomega.9b04439

2019

Gill US and McCarthy NE (2019). CD4 T cells in hepatitis B virus: You don't have to be cytotoxic to work here and help. Elsevier  Journal of Hepatology  10.1016/j.jhep.2019.10.008
Gupta N, Park JE, Tse W, Low JK, Kon OL, McCarthy N and Sze SK (2019). ERO1α promotes hypoxic tumor progression and is associated with poor prognosis in pancreatic cancer. Impact Journals  Oncotarget  vol. 10, (57) 5970-5982. 10.18632/oncotarget.27235
Cox SR, Lindsay JO, Fromentin S, Stagg AJ, McCarthy NE, Galleron N, Ibraim SB, Roume H, Levenez F, Pons N, Maziers N, Lomer MC, Ehrlich SD, Irving PM and Whelan K (2019). Effects of Low-FODMAP Diet on Symptoms, Fecal Microbiome, and Markers of Inflammation in Patients With Quiescent Inflammatory Bowel Disease in a Randomized Trial. Elsevier  Gastroenterology  10.1053/j.gastro.2019.09.024

2018

McCarthy NE and Eberl M (2018). Human γδ T-Cell Control of Mucosal Immunity and Inflammation. Frontiers Media S.a.  Front Immunol  vol. 9, 985-985. 10.3389/fimmu.2018.00985
Cox SR, Stagg AJ, Fromentin S, Ehrlich SD, McCarthy NE, Galleron N, Levenez F, Lomer M, Lindsay JO, Irving PM and Whelan K (2018). 902 - Low Fodmap Diet Improves Functional-Like Gastrointestinal Symptoms but Reduces Bifidobacteria and Faecalibacterium Prausnitzii in Quiescent Inflammatory Bowel Disease: A Randomised Controlled Trial and Metagenomic Analysis. Elsevier  Gastroenterology  vol. 154, (6) s-177. 10.1016/s0016-5085(18)31004-7
Harrow P, McCarthy N, Stagg A and Lindsay J (2018). DOP017 Increased intestinal aryl hydrocarbon receptor expression and pathway sensitivity in Crohn’s disease. Oxford University Press (Oup)  Journal of Crohn\'s and Colitis  vol. 12, (supplement_1) s41-s41. 10.1093/ecco-jcc/jjx180.054
Cox S, Stagg A, Fromentin S, Ehrlich D, McCarthy N, Galleron N, Levenez F, Lomer M, Lindsay J, Irving P and Whelan K (2018). DOP086 Low FODMAP diet improves functional-like gastrointestinal symptoms but reduces bifidobacteria and faecalibacterium prausnitzii in Quiescent inflammatory bowel disease: a randomised controlled trial and metagenomic analysis. Oxford University Press (Oup)  Journal of Crohn\'s and Colitis  vol. 12, (supplement_1) s87-s87. 10.1093/ecco-jcc/jjx180.123

2017

MCCARTHY NE, Tyler CJ, Lindsay JO, Stagg AJ, Moser B and Eberl M (2017). Antigen-presenting human γδ T-cells promote intestinal CD4+ T-cell expression of IL-22 and mucosal release of calprotectin. American Association of Immunologists  Journal of Immunology  10.4049/jimmunol.1700003

2016

Giles EM, Sanders TJ, McCarthy NE, Lung J, Pathak M, MacDonald TT, Lindsay JO and Stagg AJ (2016). Regulation of human intestinal T-cell responses by type 1 interferon-STAT1 signaling is disrupted in inflammatory bowel disease. Elsevier  Mucosal Immunology  vol. 10, (1) 184-193. 10.1038/mi.2016.44
Petty RD, McCarthy NE, Le Dieu R and Kerr JR (2016). MicroRNAs hsa-miR-99b, hsa-miR-330, hsa-miR-126 and hsa-miR-30c: Potential Diagnostic Biomarkers in Natural Killer (NK) Cells of Patients with Chronic Fatigue Syndrome (CFS)/ Myalgic Encephalomyelitis (ME). Public Library of Science (Plos)  Plos One  vol. 11, (3) 10.1371/journal.pone.0150904

2015

McCarthy NE, Hedin CR, Sanders TJ, Amon P, Hoti I, Ayada I, Baji V, Giles EM, Wildemann M, Bashir Z, Whelan K, Sanderson I, Lindsay JO and Stagg AJ (2015). Azathioprine therapy selectively ablates human Vδ2+ T cells in Crohn’s disease. American Society For Clinical Investigation  Journal of Clinical Investigation  vol. 125, (8) 3215-3225. 10.1172/JCI80840
Brugha R, Mushtaq N, McCarthy NE, Stagg AJ and Grigg J (2015). Respiratory tract dendritic cells in paediatric asthma. Clin Exp Allergy  vol. 45, (3) 624-631. 10.1111/cea.12457

2014

Sanders TJ, McCarthy NE, Giles EM, Davidson KLM, Haltalli MLR, Hazell S, Lindsay JO and Stagg AJ (2014). Increased production of retinoic acid by intestinal macrophages contributes to their inflammatory phenotype in patients with Crohn's disease. Gastroenterology  vol. 146, (5) 10.1053/j.gastro.2014.01.057
Hedin CR, McCarthy NE, Louis P, Farquharson FM, McCartney S, Taylor K, Prescott NJ, Murrells T, Stagg AJ, Whelan K and Lindsay JO (2014). Altered intestinal microbiota and blood T cell phenotype are shared by patients with Crohn's disease and their unaffected siblings. Gut  10.1136/gutjnl-2013-306226

2013

McCarthy NE, Bashir Z, Vossenkämper A, Hedin CR, Giles EM, Bhattacharjee S, Brown SG, Sanders TJ, Whelan K, MacDonald TT, Lindsay JO and Stagg AJ (2013). Proinflammatory Vδ2+ T cells populate the human intestinal mucosa and enhance IFN-γ production by colonic αβ T cells. J Immunol  vol. 191, (5) 2752-2763. 10.4049/jimmunol.1202959
Hedin C, McCarthy NE, Louis P, Farquharson F, McCartney S, Taylor K, Prescott NJ, Murrells T, Stagg AJ, Whelan K and Lindsay JO (2013). 260 Siblings of Patients With Crohn's Disease Have a Distinct Microbiological and Immune Phenotype Compared to Healthy Controls: Insights Into Disease Pathogenesis. Elsevier  Gastroenterology  vol. 144, (5) 10.1016/s0016-5085(13)60206-1

2012

Mann ER, McCarthy NE, Peake STC, Milestone AN, Al-Hassi HO, Bernardo D, Tee CT, Landy J, Pitcher MC, Cochrane SA, Hart AL, Stagg AJ and Knight SC (2012). Skin- and gut-homing molecules on human circulating γδ T cells and their dysregulation in inflammatory bowel disease. Clin Exp Immunol  vol. 170, (2) 122-130. 10.1111/j.1365-2249.2012.04649.x
Mann ER, Bernardo D, Al-Hassi HO, English NR, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart AL, Stagg AJ and Knight SC (2012). Human gut-specific homeostatic dendritic cells are generated from blood precursors by the gut microenvironment. Inflamm Bowel Dis  vol. 18, (7) 1275-1286. 10.1002/ibd.21893
Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Prescott NJ, Pessoa-Lopes P, Mathew CG, Sanderson J, Hart AL, Kamm MA, Knight SC, Forbes A, Stagg AJ, Lindsay JO and Whelan K (2012). Smokers with active Crohn's disease have a clinically relevant dysbiosis of the gastrointestinal microbiota. Inflammatory Bowel Diseases  vol. 18, (6) 1092-1100. 10.1002/ibd.21864

2011

Ng SC, Benjamin JL, McCarthy NE, Hedin CRH, Koutsoumpas A, Plamondon S, Price CL, Hart AL, Kamm MA, Forbes A, Knight SC, Lindsay JO, Whelan K and Stagg AJ (2011). Relationship between human intestinal dendritic cells, gut microbiota, and disease activity in Crohn's disease. Inflamm Bowel Dis  vol. 17, (10) 2027-2037. 10.1002/ibd.21590
Benjamin JL, Hedin CRH, Koutsoumpas A, Ng SC, McCarthy NE, Hart AL, Kamm MA, Sanderson JD, Knight SC, Forbes A, Stagg AJ, Whelan K and Lindsay JO (2011). Randomised, double-blind, placebo-controlled trial of fructo-oligosaccharides in active Crohn's disease. Gut  vol. 60, (7) 923-929. 10.1136/gut.2010.232025
Hedin CR, McCarthy NE, Bhattacharjee S, James G, Whelan K, Lindsay JO and Stagg AJ (2011). Expansion of Vδ2+T-Cells Occurs in Crohn's Disease Patients and Their Siblings: Impact of Therapy and Implications for Pathogenesis. Elsevier  Gastroenterology  vol. 140, (5) s-489. 10.1016/s0016-5085(11)62019-2

2010

Mann ER, Ordiz DB, Al-Hassi HO, Clark SK, McCarthy NE, Milestone AN, Cochrane SA, Hart A, Stagg AJ and Knight SC (2010). W1813 Human Dendritic Cell Migration Markers and Function Determine T-Cell Migration Patterns and Properties. Elsevier  Gastroenterology  vol. 138, (5) s-745. 10.1016/s0016-5085(10)63433-6

2009

Mann ER, McCarthy NE, Milestone AN, Cochrane SA, Stagg AJ, Hart A and Knight SC (2009). S1700 The Role of Human γδ T-Cells in Inflammatory Bowel Disease. Elsevier  Gastroenterology  vol. 136, (5) a-252. 10.1016/s0016-5085(09)61146-x
Mann ER, Al-Hassi HO, Clark SK, McCarthy NE, Cochrane SA, Hart A, Stagg AJ and Knight SC (2009). M1677 Imprinting of Lymphocyte Homing to Skin and Gut By Human Tissue DC. Elsevier  Gastroenterology  vol. 136, (5) a-408. 10.1016/s0016-5085(09)61876-x
Ng SC, McCarthy NE, Plamondon S, Kamm MA, Stagg AJ and Knight SC (2009). S1750 Distinct Cytokine Patterns from Multiplex Profiles of Patients with Inflammatory Bowel Disease, Functional Bowel Disorder and Healthy Controls. Elsevier  Gastroenterology  vol. 136, (5) a-262. 10.1016/s0016-5085(09)61193-8
Ng SC, Rigby R, Hart AL, Plamondon S, Gellatly N, McCarthy NE, Al-Hassi HO, Kamm MA, Knight SC and Stagg AJ (2009). P309 - Altered imprinting of lymphocyte homing by colonic dendritic cells in human ulcerative colitis. Oxford University Press (Oup)  Journal of Crohn\'s and Colitis  vol. 3, (1) s132-s132. 10.1016/s1873-9946(09)60336-6
Ng SC, McCarthy NE, Plamondon S, Kamm MA, Stagg AJ and Knight SC (2009). P316 - TNF-α production and differential release of Th1/Th2 cytokines detected in colonic tissues of inflammatory bowel disease patients but not controls. Oxford University Press (Oup)  Journal of Crohn\'s and Colitis  vol. 3, (1) s134-s135. 10.1016/s1873-9946(09)60343-3

2008

Holden NJ, Bedford PA, McCarthy NE, Marks NA, Ind PW, Jowsey IR, Basketter DA and Knight SC (2008). Dendritic cells from control but not atopic donors respond to contact and respiratory sensitizer treatment in vitro with differential cytokine production and altered stimulatory capacity. Clin Exp Allergy  vol. 38, (7) 1148-1159. 10.1111/j.1365-2222.2008.02997.x
Ng SC, Koutsoumpas A, Hedin CR, McCarthy NE, Plamondon S, Kamm MA, Knight SC, Forbes A, Lindsay JO, Whelan K and Stagg AJ (2008). W1201 Production of IL-10 By Colonic Dendritic Cells Is Associated with Higher Concentrations of Faecal Microbiota in Patients with Active Crohn's Disease. Elsevier  Gastroenterology  vol. 134, (4) 10.1016/s0016-5085(08)63051-6
Ng SC, Koutsoumpas A, Hedin CRH, McCarthy N, Plamondon S, Kamm MA, Knight SC, Forbes A, Lindsay JO, Whelan K and Stagg AJ (2008). P302 PRODUCTION OF IL-10 BY COLONIC DENDRITIC CELLS IS ASSOCIATED WITH HIGHER CONCENTRATIONS OF FAECAL MICROBIOTA IN PATIENTS WITH ACTIVE CROHN'S DISEASE. Oxford University Press (Oup)  Journal of Crohn\'s and Colitis  vol. 2, (1) 10.1016/s1873-9954(08)70313-6

2007

McCarthy NE, Jones HA, Marks NA, Shiner RJ, Ind PW, Al-Hassi HO, English NR, Murray CM, Lambert JR, Knight SC and Stagg AJ (2007). Inhaled allergen-driven CD1c up-regulation and enhanced antigen uptake by activated human respiratory-tract dendritic cells in atopic asthma. Clin Exp Allergy  vol. 37, (1) 72-82. 10.1111/j.1365-2222.2006.02631.x

Grants

Grants of specific relevance to Predictive in vitro Models
Human tissue-resident immunity to intestinal fungi
McCarthy NE
£153,432 Bart's Charity (30-09-2019 - 31-03-2023)
Investigating BTN function in inflammatory bowel disease
McCarthy NE
£316,434 ImCheck Therapeutics (01-02-2021 - 31-01-2023)
Fungal suppression by human gut Vdelta2 T-cells in mucosal immunity and inflammation
Mccarthy NE
£547,618 Medical Research Council (02-01-2018 - 01-01-2023)
Summary
Human colonic T-cell responses in Crohn's disease: modulation by phosphoantigen products of the gut microbiota
McCarthy NE
£75,000 Crohn's in Childhood Research Association (CiCRA) (01-07-2015 - 30-06-2016)
Summary
Disrupting Vδ2T-cell function in the gut: a novel approach to therapy in early stage Crohn’s disease
McCarthy NE
£60,000 Crohn’s and Colitis UK (01-06-2013 - 01-06-2014)
Summary
Vedolizumab: assessing impact on α4β7+ unconventional T-cells and α4β7+ precursors of intestinal antigen presenting cells
McCarthy NE
£129,000 Takeda Pharmaceuticals (2014 - 2017)
Summary
γδ T-cell polarisation of CD4+ T-cell responses: implications for Crohn's disease
McCarthy NE
£34,000 Wellcome Trust (2016 - 2016)
Summary