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Dr Liliane Fossati-Jimack

Liliane Fossati-Jimack

Senior Scientific Officer

William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London
+44 (0)20 7882 8194




Synovial tissue explant in vitro culture


Publications of specific relevance to Predictive in vitro Models


El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ and Pitzalis C (2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. Elsevier Bv  Journal of Autoimmunity  10.1016/j.jaut.2019.06.008
Pontarini E, Lucchesi D, Fossati-Jimack L, Coleby R, Tentorio P, Croia C, Bombardieri M and Mavilio D (2019). NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation. Journal of Leukocyte Biology  vol. 105, (3) 589-602. 10.1002/JLB.5A1117-462RR


Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulz-Knappe P, Sleeman MA and Symmons D (2018). The RA-MAP Consortium: a working model for academia-industry collaboration. Nat Rev Rheumatol  vol. 14, (1) 53-60. 10.1038/nrrheum.2017.200
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM, Ramming A, Rauber S, Schett G, Jones GW, Jones SA, Rossi FW, De Paulis A, Marone G, El Shikh MEM, Humby F and Pitzalis C (2018). Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. Annals of The Rheumatic Diseases  vol. 77, (12) 1773-1781. 10.1136/annrheumdis-2018-213418


Lewis MJ, Malik TH, Fossati-Jimack L, Carassiti D, Cook HT, Haskard DO and Botto M (2012). Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia. Arthritis and Rheumatism  vol. 64, (8) 2707-2718. 10.1002/art.34451


Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Cook HT, Walport MJ and Botto M (2008). Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice. Arthritis Rheum  vol. 58, (7) 2131-2141. 10.1002/art.23553
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Walport MJ, Cook HT and Botto M (2008). C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice. Mol Immunol  vol. 45, (3) 787-795. 10.1016/j.molimm.2007.06.162


Tas SW, Quartier P, Botto M and Fossati-Jimack L (2006). Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells. Ann Rheum Dis  vol. 65, (2) 216-221. 10.1136/ard.2005.037143


Trendelenburg M, Fossati-Jimack L, Cortes-Hernandez J, Turnberg D, Lewis M, Izui S, Cook HT and Botto M (2005). The role of complement in cryoglobulin-induced immune complex glomerulonephritis. J Immunol  vol. 175, (10) 6909-6914. 10.4049/jimmunol.175.10.6909


Haywood MEK, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Lewis MR, Fossati-Jimack L, Izui S, Walport MJ and Morley BJ (2004). Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease. Journal of Immunology  vol. 173, (7) 4277-4285. 10.4049/jimmunol.173.7.4277
Trendelenburg M, Manderson AP, Fossati-Jimack L, Walport MJ and Botto M (2004). Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice. Immunology  vol. 113, (1) 80-88. 10.1111/j.1365-2567.2004.01940.x


Hügin AW, Fossati-Jimack L and Izui S (2000). The Autoimmune Accelerating Yaa Mutation Does Not Accelerate Murine AIDS. Elsevier Bv  Cellular Immunology  vol. 200, (2) 76-80. 10.1006/cimm.2000.1611


IZUI S, IWAMOTO M, FOSSATI U, MERINO R, TAKAHASHI S and IBNOU-ZEKRI N (1995). The Yaa Gene Model of Systemic Lupus Erythematosus. Wiley  Immunological Reviews  vol. 144, (1) 137-156. 10.1111/j.1600-065x.1995.tb00068.x


Izui S, Merino R, Fossati L and Iwamoto M (1994). The Role of the Yaa Gene in Lupus Syndrome. Informa Uk Limited  International Reviews of Immunology  vol. 11, (3) 211-230. 10.3109/08830189409061728


Merino R, Fossati L, Lacour M and Izui S (1991). Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice. Rockefeller University Press  The Journal of Experimental Medicine  vol. 174, (5) 1023-1029. 10.1084/jem.174.5.1023