Publications

Publications of specific relevance to Predictive in vitro Models
2022

Isaacs JD, Brockbank S, Pedersen AW, Hilkens C, Anderson A, Stocks P, Lendrem D, Tarn J, Smith GR, Allen B, Casement J, Diboll J, Harry R, Cooles FAH, Cope AP, Simpson G, Toward R, Noble H, Parke A, Wu W, Clarke F, Scott D, Scott IC, Galloway J, Lempp H, Ibrahim F, Schwank S, Molyneux G, Lazarov T and Geissmann F (2022).
RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients. Scientific Data vol. 9, (1)
10.1038/s41597-022-01264-y
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A,
Fossati-Jimack L, Thorborn G, Ahmed M, Prediletto E, Church SE, Hudson BM, Warren SE, McKeigue PM, Humby F, Bombardieri M, Barnes MR, Lewis MJ, Pitzalis C, Bombardieri M, Lewis MJ, Durez P, Buch MH, Rizvi H, Mahto A, Montecucco C, Lauwerys B and Ng N (2022).
Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial. Nature Medicine vol. 28, (6) 1256-1268.
10.1038/s41591-022-01789-0
Elshikh M, El Sayed R, Aly N, Prediletto E, Hands R,
Fossati-Jimack L, Bombardieri M, Lewis M and Pitzalis C (2022).
POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM. Annals of The Rheumatic Diseases vol. 81, (Suppl 1) 470.1-47470.
10.1136/annrheumdis-2022-eular.33582021

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K,
Fossati-Jimack L, Emery P, Ng WF, Sutcliffe N, Everett C, Fernandez C, Tappuni A, Lewis M, Pitzalis C, Bowman SJ and Bombardieri M (2021).
OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL. Annals of The Rheumatic Diseases vol. 80, (Suppl 1) 79-80.
10.1136/annrheumdis-2021-eular.3960
Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D,
Fossati-Jimack L, Coleby R, Chowdhury F, Calcaterra F, Tappuni A, Lewis MJ, Fabris M, Quartuccio L, Bella SD, Bowman S, Pitzalis C, Mavilio D, De Vita S and Bombardieri M (2021).
NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment. Frontiers in Immunology vol. 12,
10.3389/fimmu.2021.706737
Rivellese F, Pontarini E,
Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C, Goldmann K, Bombardieri M, Lewis M and Pitzalis C (2021).
OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE. Annals of The Rheumatic Diseases vol. 80, (Suppl 1) 7.2-7.7.
10.1136/annrheumdis-2021-eular.438
Ferrari M, Onuoha SC,
Fossati-Jimack L, Nerviani A, Alves PL, Pagani S, Deantonio C, Colombo F, Santoro C, Sblattero D and Pitzalis C (2021).
Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis. Frontiers in Immunology vol. 12,
10.3389/fimmu.2021.640070
Jackson WD, Gulino A,
Fossati-Jimack L, Castro Seoane R, Tian K, Best K, Köhl J, Belmonte B, Strid J and Botto M (2021).
C3 Drives Inflammatory Skin Carcinogenesis Independently of C5. Journal of Investigative Dermatology vol. 141, (2) 404-414.e6.
10.1016/j.jid.2020.06.025
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G, Mahto A, Montecucco C, Lauwerys B, Ng N, Ho P, Bombardieri M, Romão VC, Verschueren P, Kelly S, Sainaghi PP, Gendi N, Dasgupta B, Cauli A, Reynolds P, Cañete JD, Moots R, Taylor PC, Edwards CJ, Isaacs J, Sasieni P, Choy E and Pitzalis C (2021).
Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial. The Lancet vol. 397, (10271) 305-317.
10.1016/S0140-6736(20)32341-22020

Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F,
Fossati-Jimack L, Astorri E, Prediletto E, Corsiero E, Romana Delvecchio F, Coleby R, Gelbhardt E, Bono A, Baldini C, Puxeddu I, Ruscitti P, Giacomelli R, Barone F, Fisher B, Bowman SJ, Colafrancesco S, Priori R, Sutcliffe N, Challacombe S, Carlesso G, Tappuni A, Pitzalis C and Bombardieri M (2020).
Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma. Annals of The Rheumatic Diseases vol. 79, (12) 1588-1599.
10.1136/annrheumdis-2020-217646
Rivellese F, Humby F, Bugatti S,
Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C and PEAC- R4RA investigators (2020).
B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure. Wiley Arthritis and Rheumatology 10.1002/art.411842019

El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R,
Fossati-Jimack L, Lewis MJ and Pitzalis C (2019).
Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. Elsevier Bv Journal of Autoimmunity 10.1016/j.jaut.2019.06.008
Pontarini E, Lucchesi D,
Fossati-Jimack L, Coleby R, Tentorio P, Croia C, Bombardieri M and Mavilio D (2019).
NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation. Journal of Leukocyte Biology vol. 105, (3) 589-602.
10.1002/JLB.5A1117-462RR2018

Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulz-Knappe P, Sleeman MA and Symmons D (2018).
The RA-MAP Consortium: a working model for academia-industry collaboration. Nat Rev Rheumatol vol. 14, (1) 53-60.
10.1038/nrrheum.2017.200
Rivellese F, Mauro D, Nerviani A, Pagani S,
Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM, Ramming A, Rauber S, Schett G, Jones GW, Jones SA, Rossi FW, De Paulis A, Marone G, El Shikh MEM, Humby F and Pitzalis C (2018).
Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. Annals of The Rheumatic Diseases vol. 77, (12) 1773-1781.
10.1136/annrheumdis-2018-2134182016

Barbour TD, Ling GS, Ruseva MM,
Fossati-Jimack L, Cook HT, Botto M and Pickering MC (2016).
Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy. Kidney Int vol. 89, (4) 823-832.
10.1016/j.kint.2015.11.0242015

Saja MF, Baudino L, Jackson WD, Cook HT, Malik TH,
Fossati-Jimack L, Ruseva M, Pickering MC, Woollard KJ and Botto M (2015).
Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes. Cell Rep vol. 12, (11) 1802-1815.
10.1016/j.celrep.2015.08.020
Fossati-Jimack L, Ling GS, Baudino L, Szajna M, Manivannan K, Zhao JC, Midgley R, Chai J-G, Simpson E, Botto M and Scott D (2015).
Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency. Immunology vol. 144, (1) 149-157.
10.1111/imm.123582014

Banda NK, Mehta G, Chao Y, Wang G, Inturi S,
Fossati-Jimack L, Botto M, Wu L, Moghimi SM and Simberg D (2014).
Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum. Part Fibre Toxicol vol. 11,
10.1186/s12989-014-0064-2
Sattler S, Ling G-S, Xu D, Hussaarts L, Romaine A, Zhao H,
Fossati-Jimack L, Malik T, Cook HT, Botto M, Lau Y-L, Smits HH, Liew FY and Huang F-P (2014).
IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut. J Autoimmun vol. 50, 107-122.
10.1016/j.jaut.2014.01.032
Baudino L, Sardini A, Ruseva MM,
Fossati-Jimack L, Cook HT, Scott D, Simpson E and Botto M (2014).
C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A vol. 111, (4) 1503-1508.
10.1073/pnas.1316877111
Ling GS, Bennett J, Woollard KJ, Szajna M,
Fossati-Jimack L, Taylor PR, Scott D, Franzoso G, Cook HT and Botto M (2014).
Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages. Nat Commun vol. 5,
10.1038/ncomms40392013
Fossati-Jimack L, Ling GS, Cortini A, Szajna M, Malik TH, McDonald JU, Pickering MC, Cook HT, Taylor PR and Botto M (2013).
Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. Plos One vol. 8, (2)
10.1371/journal.pone.00570822012

Lewis MJ, Malik TH,
Fossati-Jimack L, Carassiti D, Cook HT, Haskard DO and Botto M (2012).
Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia. Arthritis and Rheumatism vol. 64, (8) 2707-2718.
10.1002/art.34451
Tarzi RM, Sharp PEH, McDaid JP,
Fossati-Jimack L, Herbert PE, Pusey CD, Cook HT and Warrens AN (2012).
Mice with defective Fas ligand are protected from crescentic glomerulonephritis. Kidney Int vol. 81, (2) 170-178.
10.1038/ki.2011.3192011

McDonald JU, Cortini A, Rosas M,
Fossati-Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K, Brown GD, Jones SA, Hallett MB, Botto M and Taylor PR (2011).
In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. Faseb J vol. 25, (6) 1972-1982.
10.1096/fj.10-1785172010

Santiago-Raber M-L, Amano H, Amano E,
Fossati-Jimack L, Swee LK, Rolink A and Izui S (2010).
Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation. J Autoimmun vol. 34, (4) 349-355.
10.1016/j.jaut.2010.01.001
Carlucci F,
Fossati-Jimack L, Dumitriu IE, Heidari Y, Walport MJ, Szajna M, Baruah P, Garden OA, Cook HT and Botto M (2010).
Identification and characterization of a lupus suppressor 129 locus on chromosome 3. J Immunol vol. 184, (11) 6256-6265.
10.4049/jimmunol.09014632009

Heidari Y,
Fossati-Jimack L, Carlucci F, Walport MJ, Cook HT and Botto M (2009).
A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice. Genes Immun vol. 10, (1) 47-55.
10.1038/gene.2008.782008

Baudino L, Yoshinobu K, Morito N, Kikuchi S,
Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S, Jørgensen TN, Tucker RM, Roark CL, Kotzin BL, Evans LH and Izui S (2008).
Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis. J Immunol vol. 181, (4) 2846-2854.
10.4049/jimmunol.181.4.2846
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Cook HT, Walport MJ and Botto M (2008).
Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice. Arthritis Rheum vol. 58, (7) 2131-2141.
10.1002/art.23553
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Walport MJ, Cook HT and Botto M (2008).
C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice. Mol Immunol vol. 45, (3) 787-795.
10.1016/j.molimm.2007.06.1622007

Baudino L,
Fossati-Jimack L, Chevalley C, Martinez-Soria E, Shulman MJ and Izui S (2007).
IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation. Blood vol. 109, (12) 5355-5362.
10.1182/blood-2006-11-059899
Carlucci F, Cortes-Hernandez J,
Fossati-Jimack L, Bygrave AE, Walport MJ, Vyse TJ, Cook HT and Botto M (2007).
Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice. J Immunol vol. 178, (4) 2352-2360.
10.4049/jimmunol.178.4.23522006

Kikuchi S, Santiago-Raber M-L, Amano H, Amano E,
Fossati-Jimack L, Moll T, Kotzin BL and Izui S (2006).
Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol vol. 176, (5) 3240-3247.
10.4049/jimmunol.176.5.3240
Tas SW, Quartier P, Botto M and
Fossati-Jimack L (2006).
Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells. Ann Rheum Dis vol. 65, (2) 216-221.
10.1136/ard.2005.0371432005

Trendelenburg M,
Fossati-Jimack L, Cortes-Hernandez J, Turnberg D, Lewis M, Izui S, Cook HT and Botto M (2005).
The role of complement in cryoglobulin-induced immune complex glomerulonephritis. J Immunol vol. 175, (10) 6909-6914.
10.4049/jimmunol.175.10.6909
Amano H, Amano E, Santiago-Raber M-L, Moll T, Martinez-Soria E,
Fossati-Jimack L, Iwamoto M, Rozzo SJ, Kotzin BL and Izui S (2005).
Selective expansion of a monocyte subset expressing the CD11c dendritic cell marker in the Yaa model of systemic lupus erythematosus. Arthritis Rheum vol. 52, (9) 2790-2798.
10.1002/art.21365
Kikuchi S, Amano H, Amano E,
Fossati-Jimack L, Santiago-Raber M-L, Moll T, Ida A, Kotzin BL and Izui S (2005).
Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice. Blood vol. 106, (4) 1323-1329.
10.1182/blood-2005-02-0558
Kikuchi S,
Fossati-Jimack L, Moll T, Amano H, Amano E, Ida A, Ibnou-Zekri N, Laporte C, Santiago-Raber M-L, Rozzo SJ, Kotzin BL and Izui S (2005).
Differential role of three major New Zealand Black-derived loci linked with Yaa-induced murine lupus nephritis. J Immunol vol. 174, (2) 1111-1117.
10.4049/jimmunol.174.2.11112004

Cortes-Hernandez J,
Fossati-Jimack L, Petry F, Loos M, Izui S, Walport MJ, Cook HT and Botto M (2004).
Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice. Eur J Immunol vol. 34, (12) 3713-3722.
10.1002/eji.200425616
Haywood MEK, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Lewis MR,
Fossati-Jimack L, Izui S, Walport MJ and Morley BJ (2004).
Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease. Journal of Immunology vol. 173, (7) 4277-4285.
10.4049/jimmunol.173.7.4277
Lee NJ, Rigby RJ, Gill H, Boyle JJ,
Fossati-Jimack L, Morley BJ and Vyse TJ (2004).
Multiple loci are linked with anti-red blood cell antibody production in NZB mice -- comparison with other phenotypes implies complex modes of action. Clin Exp Immunol vol. 138, (1) 39-46.
10.1111/j.1365-2249.2004.02560.x
Kuroki A, Moll T, López-Hoyos M,
Fossati-Jimack L, Ibnou-Zekri N, Kikuchi S, Merino J, Merino R and Izui S (2004).
Enforced Bcl-2 expression in B lymphocytes induces rheumatoid factor and anti-DNA production, but the Yaa mutation promotes only anti-DNA production. Eur J Immunol vol. 34, (4) 1077-1084.
10.1002/eji.200424859
Norsworthy PJ,
Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ and Botto M (2004).
Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells in Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis. Journal of Immunology vol. 172, (6) 3406-3414.
10.4049/jimmunol.172.6.34062003

Lajaunias F, Ida A, Kikuchi S,
Fossati-Jimack L, Martinez-Soria E, Moll T, Law C-L and Izui S (2003).
Differential control of CD22 ligand expression on B and T lymphocytes, and enhanced expression in murine systemic lupus. Arthritis Rheum vol. 48, (6) 1612-1621.
10.1002/art.110212002

Tarzi RM, Davies KA, Robson MG,
Fossati-Jimack L, Saito T, Walport MJ and Cook HT (2002).
Nephrotoxic nephritis is mediated by Fcgamma receptors on circulating leukocytes and not intrinsic renal cells. Kidney Int vol. 62, (6) 2087-2096.
10.1046/j.1523-1755.2002.00687.x
Cortes-Hernandez J,
Fossati-Jimack L, Carugati A, Potter PK, Walport MJ, Cook HT and Botto M (2002).
Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms. Clin Exp Immunol vol. 130, (3) 459-466.
10.1046/j.1365-2249.2002.01998.x
Kikuchi S, Pastore Y,
Fossati-Jimack L, Kuroki A, Yoshida H, Fulpius T, Araki K, Takahashi S, Lemoine R, Reininger L and Izui S (2002).
A transgenic mouse model of autoimmune glomerulonephritis and necrotizing arteritis associated with cryoglobulinemia. J Immunol vol. 169, (8) 4644-4650.
10.4049/jimmunol.169.8.4644
Kuroki A, Kuroda Y, Kikuchi S, Lajaunias F, Fulpius T, Pastore Y,
Fossati-Jimack L, Reininger L, Toda T, Nakata M, Kojima N, Mizuochi T and Izui S (2002).
Level of galactosylation determines cryoglobulin activity of murine IgG3 monoclonal rheumatoid factor. Blood vol. 99, (8) 2922-2928.
10.1182/blood.v99.8.2922
Azeredo da Silveira S, Kikuchi S,
Fossati-Jimack L, Moll T, Saito T, Verbeek JS, Botto M, Walport MJ, Carroll M and Izui S (2002).
Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med vol. 195, (6) 665-672.
10.1084/jem.20012024
Mitchell DA, Pickering MC, Warren J,
Fossati-Jimack L, Cortes-Hernandez J, Cook HT, Botto M and Walport MJ (2002).
C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol vol. 168, (5) 2538-2543.
10.4049/jimmunol.168.5.2538
Fossati-Jimack L, Azeredo da Silveira S, Moll T, Kina T, Kuypers FA, Oldenborg P-A, Reininger L and Izui S (2002).
Selective increase of autoimmune epitope expression on aged erythrocytes in mice: implications in anti-erythrocyte autoimmune responses. J Autoimmun vol. 18, (1) 17-25.
10.1006/jaut.2001.05632001

Izui S,
Fossati-Jimack L, da Silveira SA and Moll T (2001).
Isotype-dependent pathogenicity of autoantibodies: analysis in experimental autoimmune hemolytic anemia. Springer Semin Immunopathol vol. 23, (4) 433-445.
10.1007/s281-001-8169-1
Mizuochi T, Pastore Y, Shikata K, Kuroki A, Kikuchi S, Fulpius T, Nakata M,
Fossati-Jimack L, Reininger L, Matsushita M, Fujita T and Izui S (2001).
Role of galactosylation in the renal pathogenicity of murine immunoglobulin G3 monoclonal cryoglobulins. Blood vol. 97, (11) 3537-3543.
10.1182/blood.v97.11.35372000

Chicheportiche Y,
Fossati-Jimack L, Moll S, Ibnou-Zekri N and Izui S (2000).
Down-regulated expression of TWEAK mRNA in acute and chronic inflammatory pathologies. Biochem Biophys Res Commun vol. 279, (1) 162-165.
10.1006/bbrc.2000.3913
Fossati-Jimack L, Ioan-Facsinay A, Reininger L, Chicheportiche Y, Watanabe N, Saito T, Hofhuis FM, Gessner JE, Schiller C, Schmidt RE, Honjo T, Verbeek JS and Izui S (2000).
Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III. J Exp Med vol. 191, (8) 1293-1302.
10.1084/jem.191.8.12931999
Fossati-Jimack L, Reininger L, Chicheportiche Y, Clynes R, Ravetch JV, Honjo T and Izui S (1999).
High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia. J Exp Med vol. 190, (11) 1689-1696.
10.1084/jem.190.11.16891997

Ibnou-Zekri N, Iwamoto M, Fossati L, McConahey PJ and Izui S (1997).
Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice. Proc Natl Acad Sci U S A vol. 94, (26) 14654-14659.
10.1073/pnas.94.26.14654
Santiago ML, Fossati L, Jacquet C, Müller W, Izui S and Reininger L (1997).
Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J Exp Med vol. 185, (1) 65-70.
10.1084/jem.185.1.651996

Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T and Izui S (1996).
Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest vol. 97, (7) 1597-1604.
10.1172/JCI1185841995

Fossati L, Sobel ES, Iwamoto M, Cohen PL, Eisenberg RA and Izui S (1995).
The Yaa gene-mediated acceleration of murine lupus: Yaa- T cells from non-autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo. Eur J Immunol vol. 25, (12) 3412-3417.
10.1002/eji.1830251231
Moll S, Menoud PA, Fulpius T, Pastore Y, Takahashi S, Fossati L, Vassalli JD, Sappino AP, Schifferli JA and Izui S (1995).
Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis. Kidney Int vol. 48, (5) 1459-1468.
10.1038/ki.1995.435
Izui S, Iwamoto M, Fossati L, Merino R, Takahashi S and Ibnou-Zekri N (1995).
The Yaa gene model of systemic lupus erythematosus. Immunol Rev vol. 144, 137-156.
10.1111/j.1600-065x.1995.tb00068.x
Merino R, Fossati L, Iwamoto M, Takahashi S, Lemoine R, Ibnou-Zekri N, Pugliatti L, Merino J and Izui S (1995).
Effect of long-term anti-CD4 or anti-CD8 treatment on the development of lpr CD4- CD8- double negative T cells and of the autoimmune syndrome in MRL-lpr/lpr mice. J Autoimmun vol. 8, (1) 33-45.
10.1006/jaut.1995.0003
Fossati L, Iwamoto M, Merino R and Izui S (1995).
Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens. Eur J Immunol vol. 25, (1) 166-173.
10.1002/eji.18302501281994

Herrera PL, Harlan DM, Fossati L, Izui S, Huarte J, Orci L, Vassalli JD and Vassalli P (1994).
A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice. Diabetologia vol. 37, (12) 1277-1279.
10.1007/BF00399802
Fossati L, Merino R, Iwamoto M, Lemoine R and Izui S (1994).
Lack of association of V beta 8+ T cells with lupus-like syndrome in MRL-lpr/lpr mice. Eur J Immunol vol. 24, (7) 1717-1720.
10.1002/eji.1830240741
Izui S, Berney T, Shibata T, Fulpius T, Fossati L and Merino R (1994).
Molecular and cellular basis for pathogenicity of autoantibodies. Tohoku J Exp Med vol. 173, (1) 15-30.
10.1620/tjem.173.15
Izui S, Merino R, Fossati L and Iwamoto M (1994).
The role of the Yaa gene in lupus syndrome. Int Rev Immunol vol. 11, (3) 211-230.
10.3109/08830189409061728
Izui S, Merino R, Iwamoto M and Fossati L (1994).
Mechanisms of genetic control of murine systemic lupus erythematosus. Springer Semin Immunopathol vol. 16, (2-3) 133-152.
10.1007/BF001975141993

Merino R, Iwamoto M, Fossati L, Muniesa P, Araki K, Takahashi S, Huarte J, Yamamura K, Vassalli JD and Izui S (1993).
Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain. J Exp Med vol. 178, (4) 1189-1197.
10.1084/jem.178.4.1189
Fossati L, Takahashi S, Merino R, Iwamoto M, Aubry JP, Nose M, Spach C, Motta R and Izui S (1993).
An MRL/MpJ-lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome. Int Immunol vol. 5, (5) 525-532.
10.1093/intimm/5.5.5251992

Cerny A, Merino R, Fossati L, de Kossodo S, Heusser C, Waldvogel FA, Morse HC and Izui S (1992).
Effect of cyclosporin A and zidovudine on immune abnormalities observed in the murine acquired immunodeficiency syndrome. J Infect Dis vol. 166, (2) 285-290.
10.1093/infdis/166.2.285
Merino R, Fossati L, Lacour M, Lemoine R, Higaki M and Izui S (1992).
H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Eur J Immunol vol. 22, (2) 295-299.
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Merino R, Fossati L and Izui S (1992).
The lupus-prone BXSB strain: the Yaa gene model of systemic lupus erythematosus. Springer Semin Immunopathol vol. 14, (2) 141-157.
10.1007/BF001952911991

Merino R, Fossati L, Lacour M and Izui S (1991).
Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice. J Exp Med vol. 174, (5) 1023-1029.
10.1084/jem.174.5.10231990

Reininger L, Shibata T, Schurmans S, Merino R, Fossati L, Lacour M and Izui S (1990).
Spontaneous production of anti-mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice. Eur J Immunol vol. 20, (11) 2405-2410.
10.1002/eji.1830201107
Fossati L, Merino J and Izui S (1990).
CD4+ T cells play a major role for IgM and IgG anti-DNA production in mice infected with Plasmodium yoelii. Clin Exp Immunol vol. 79, (2) 291-296.
10.1111/j.1365-2249.1990.tb05193.x