Dr Liliane Fossati-Jimack

Liliane Fossati-Jimack

Senior Scientific Officer

William Harvey Research Institute
Faculty of Medicine and Dentistry, Queen Mary University of London
ORCiD

Research

Interests

Synovial tissue explant in vitro culture

Publications

Publications of specific relevance to Predictive in vitro Models

2023

Pontarini E, Sciacca E, Chowdhury F, Grigoriadou S, Rivellese F, Murray‐Brown WJ, Lucchesi D, Fossati‐Jimack L, Nerviani A, Jaworska E, Ghirardi GM, Giacomassi C, Emery P, Ng WF, Sutcliffe N, Everett C, Fernandez C, Tappuni A, Seror R, Mariette X, Porcher R, Cavallaro G, Pulvirenti A, Verstappen GM, de Wolff L, Arends S, Bootsma H, Lewis MJ, Pitzalis C and Bowman SJ (2023). Serum and Tissue Biomarkers Associated With Composite of Relevant Endpoints for Sjögren Syndrome (CRESS) and Sjögren Tool for Assessing Response (STAR) to B Cell–Targeted Therapy in the Trial of Anti–B Cell Therapy in Patients With Primary Sjögren Syndrome (TRACTISS). Wiley  Arthritis & Rheumatology  10.1002/art.42772
Boutet M-A, Nerviani A, Fossati-Jimack L, Hands-Greenwood R, Ahmed M, Rivellese F and Pitzalis C (2023). Comparative analysis of late-stage rheumatoid arthritis and osteoarthritis reveals shared histopathological features. Elsevier  Osteoarthritis and Cartilage  vol. 32, (2) 166-176. 10.1016/j.joca.2023.10.009
Ghirardi GM, Nerviani A, Fossati-Jimack L, Pontarini E, Italiani P, Pratesi F, Abdelmoaty S, Högerkorp C and Pitzalis C (2023). AB0067 MODE OF ACTION AND TARGET INVESTIGATION OF THE NEW ANTI-RHEUMATIC DRUG RABEXIMOD. Bmj  10.1136/annrheumdis-2023-eular.5727

2022

Shikh MEME, Sayed RE, Aly NAR, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis MJ and Pitzalis C (2022). Follicular dendritic cell differentiation is associated with distinct synovial pathotype signatures in rheumatoid arthritis. Frontiers  Frontiers in Medicine  vol. 9, 10.3389/fmed.2022.1013660
Humby F, Durez P, Buch MH, Lewis MJ, Bombardieri M, John C, Rizvi H, Warren L, Peel J, Fossati-Jimack L, Hands RE, Giorli G, Rivellese F, Cañete JD, Taylor PC, Sasieni P, Fonseca JE, Choy E and Pitzalis C (2022). Rituximab versus tocilizumab and B-cell status in TNF-alpha inadequate-responder rheumatoid arthritis patients:the R4-RA RCT. National Institute For Health and Care Research  Efficacy and Mechanism Evaluation  vol. 9, (7) 1-58. 10.3310/gopl1729
Cooles FAH, Tarn J, Lendrem DW, Naamane N, Lin CM, Millar B, Maney NJ, Anderson AE, Thalayasingam N, Diboll J, Bondet V, Duffy D, Barnes MR, Smith GR, Ng S, Watson D, Henkin R, Cope AP, Reynard LN, Pratt AG, Isaacs JD, Hughes-Morley A, Walker A, Cuza A, Gallagher-Syed A, Anderson A, Haynes A, Filer A and Long A (2022). Interferon-α-mediated therapeutic resistance in early rheumatoid arthritis implicates epigenetic reprogramming. Bmj  Annals of The Rheumatic Diseases  vol. 81, (9) 1214-1223. 10.1136/annrheumdis-2022-222370
Elshikh M, El Sayed R, Aly N, Prediletto E, Hands R, Fossati-Jimack L, Bombardieri M, Lewis M and Pitzalis C (2022). POS0431 PDGF-BB, TNF-α, AND LT-β REGULATE FOLLICULAR DENDRITIC CELL DEVELOPMENT IN THE RHEUMATOID SYNOVIUM. Bmj  Annals of The Rheumatic Diseases  vol. 81, (Suppl 1) 470.1-47470. 10.1136/annrheumdis-2022-eular.3358
Surace A, Sciacca E, Goldmann K, Rivellese F, Cubuk C, Giorli G, Fossati-Jimack L, Ahmed M, Prediletto E, Bombardieri M, Lewis M and Pitzalis C (2022). OP0077 SYNOVIAL RNA-SEQ ANALYSIS OF THE R4RA TRIAL IDENTIFIES SIGNATURES OF TREATMENT RESISTANCE AND REFRACTORY STATE IN RHEUMATOID ARTHRITIS. Bmj  Annals of The Rheumatic Diseases  vol. 81, (Suppl 1) 52.2-5253. 10.1136/annrheumdis-2022-eular.4380
Rivellese F, Cubuk C, Surace A, Goldmann K, Sciacca E, Giorli G, Nerviani A, Fossati-Jimack L, Thorborn G, Bombardieri M, Barnes M, Lewis M and Pitzalis C (2022). OP0085 CELL LINEAGE-SPECIFIC TRANSCRIPT DECONVOLUTION OF SYNOVIAL BIOPSIES FROM THE R4RA TRIAL IDENTIFIES CELL POPULATIONS ASSOCIATED WITH RESPONSE TO RITUXIMAB AND TOCILIZUMAB. Bmj  Annals of The Rheumatic Diseases  vol. 81, (Suppl 1) 56.2-5657. 10.1136/annrheumdis-2022-eular.4794
Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Murray-Brown W, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L, Jaworska E, Ghirardi GM, Nerviani A, Emery P, Ng WF, Sutcliffe N, Tappuni A, Lewis M, Arends S, De Wolff L, Bootsma H, Pitzalis C, Bowman SJ and Bombardieri M (2022). POS0145 CLINICAL RESPONSE TO RITUXIMAB IS ASSOCIATED WITH PREVENTION OF B-CELL DRIVEN SALIVARY GLAND INFLAMMATION AND EPITHELIAL RESTORATION AS REVEALED BY MOLECULAR PATHOLOGY: RESULTS FROM THE TRACTISS TRIAL IN PRIMARY SJOGREN’S SYNDROME. Bmj  Annals of The Rheumatic Diseases  vol. 81, (Suppl 1) 299.2-29300. 10.1136/annrheumdis-2022-eular.4458
Rivellese F, Surace AEA, Goldmann K, Sciacca E, Çubuk C, Giorli G, John CR, Nerviani A, Fossati-Jimack L, Thorborn G, Ahmed M, Prediletto E, Church SE, Hudson BM, Warren SE, McKeigue PM, Humby F, Bombardieri M, Barnes MR, Lewis MJ and Pitzalis C (2022). Rituximab versus tocilizumab in rheumatoid arthritis: synovial biopsy-based biomarker analysis of the phase 4 R4RA randomized trial. Springer Nature  Nature Medicine  vol. 28, (6) 1256-1268. 10.1038/s41591-022-01789-0
(2022). RA-MAP, molecular immunological landscapes in early rheumatoid arthritis and healthy vaccine recipients. Springer Nature  Scientific Data  vol. 9, (1) 10.1038/s41597-022-01264-y

2021

Pontarini E, Chowdhury F, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Goldmann K, Fossati-Jimack L, Emery P, Ng WF, Sutcliffe N, Everett C, Fernandez C, Tappuni A, Lewis M, Pitzalis C, Bowman SJ and Bombardieri M (2021). OP0136 RITUXIMAB PREVENTS THE PROGRESSION OF B-CELL DRIVEN INFLAMMATORY INFILTRATE IN THE MINOR SALIVARY GLANDS OF PRIMARY SJOGREN’S SYNDROME BY DOWNREGULATING IMMUNOLOGICAL PATHWAYS KEY IN ECTOPIC GERMINAL CENTRE ORGANIZATION: RESULTS FROM THE TRACTISS TRIAL. Annals of The Rheumatic Diseases  vol. 80, (Suppl 1) 79-80. 10.1136/annrheumdis-2021-eular.3960
Pontarini E, Sciacca E, Grigoriadou S, Rivellese F, Lucchesi D, Fossati-Jimack L, Coleby R, Chowdhury F, Calcaterra F, Tappuni A, Lewis MJ, Fabris M, Quartuccio L, Della Bella S, Bowman S, Pitzalis C, Mavilio D, De Vita S and Bombardieri M (2021). NKp30 Receptor Upregulation in Salivary Glands of Sjögren’s Syndrome Characterizes Ectopic Lymphoid Structures and Is Restricted by Rituximab Treatment. Frontiers  Frontiers in Immunology  vol. 12, 10.3389/fimmu.2021.706737
Rivellese F, Pontarini E, Fossati-Jimack L, Moura RA, Romão VC, Fonseca JE, Nerviani A, Cubuk C, Goldmann K, Bombardieri M, Lewis M and Pitzalis C (2021). OP0011 INTEGRATION OF FLOW AND DIGITAL CYTOMETRY IN EARLY TREATMENT-NAÏVE RHEUMATOID ARTHRITIS IDENTIFIES DISTINCT IMMUNOPHENOTYPES IN PERIPHERAL BLOOD AND DISEASE TISSUE. Bmj  Annals of The Rheumatic Diseases  vol. 80, (Suppl 1) 7.2-7.7. 10.1136/annrheumdis-2021-eular.438
Ferrari M, Onuoha SC, Fossati-Jimack L, Nerviani A, Alves PL, Pagani S, Deantonio C, Colombo F, Santoro C, Sblattero D and Pitzalis C (2021). Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis. Frontiers in Immunology  vol. 12, 10.3389/fimmu.2021.640070
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G, Mahto A, Montecucco C, Lauwerys B, Ng N, Ho P, Bombardieri M, Romão VC, Verschueren P, Kelly S, Sainaghi PP, Gendi N, Dasgupta B, Cauli A, Reynolds P, Cañete JD, Moots R, Taylor PC, Edwards CJ, Isaacs J, Sasieni P, Choy E and Pitzalis C (2021). Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial. Elsevier  The Lancet  vol. 397, (10271) 305-317. 10.1016/s0140-6736(20)32341-2

2020

Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E, Prediletto E, Corsiero E, Delvecchio FR, Coleby R, Gelbhardt E, Bono A, Baldini C, Puxeddu I, Ruscitti P, Giacomelli R, Barone F, Fisher B, Bowman SJ, Colafrancesco S, Priori R, Sutcliffe N, Challacombe S, Carlesso G, Tappuni A, Pitzalis C and Bombardieri M (2020). Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren’s syndrome with ectopic germinal centres and MALT lymphoma. Bmj  Annals of The Rheumatic Diseases  vol. 79, (12) 1588-1599. 10.1136/annrheumdis-2020-217646
Jackson WD, Gulino A, Fossati-Jimack L, Seoane RC, Tian K, Best K, Köhl J, Belmonte B, Strid J and Botto M (2020). C3 Drives Inflammatory Skin Carcinogenesis Independently of C5. Elsevier  Journal of Investigative Dermatology  vol. 141, (Immunobiology 209 7 ) 404-414.e6. 10.1016/j.jid.2020.06.025
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands R, Giorli G, Frias B, Thornborn G, Jaworska E, John C, Goldmann K, Lewis M, Manzo A, Bombardieri M, Pitzalis C, investigators P and investigators R (2020). P233 B cell-rich synovitis in early and established rheumatoid arthritis. Rheumatology  vol. 59, (Supplement_2) 10.1093/rheumatology/keaa111.227
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C and PEAC- R4RA investigators (2020). B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure. Wiley  Arthritis and Rheumatology  10.1002/art.41184

2019

El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ and Pitzalis C (2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. Elsevier Bv  Journal of Autoimmunity  10.1016/j.jaut.2019.06.008

2018

Pontarini E, Lucchesi D, Fossati‐Jimack L, Coleby R, Tentorio P, Croia C, Bombardieri M and Mavilio D (2018). NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation. Oxford University Press (Oup)  Journal of Leukocyte Biology  vol. 105, (3) 589-602. 10.1002/jlb.5a1117-462rr
Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulz-Knappe P, Sleeman MA and Symmons D (2018). The RA-MAP Consortium: a working model for academia-industry collaboration. Nat Rev Rheumatol  vol. 14, (1) 53-60. 10.1038/nrrheum.2017.200
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM, Ramming A, Rauber S, Schett G, Jones GW, Jones SA, Rossi FW, de Paulis A, Marone G, Shikh MEME, Humby F and Pitzalis C (2018). Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. Bmj  Annals of The Rheumatic Diseases  vol. 77, (12) 10.1136/annrheumdis-2018-213418

2016

Barbour TD, Ling GS, Ruseva MM, Fossati-Jimack L, Cook HT, Botto M and Pickering MC (2016). Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy. Elsevier  Kidney International  vol. 89, (4) 823-832. 10.1016/j.kint.2015.11.024

2015

Saja MF, Baudino L, Jackson WD, Cook HT, Malik TH, Fossati-Jimack L, Ruseva M, Pickering MC, Woollard KJ and Botto M (2015). Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1low Monocytes. Elsevier  Cell Reports  vol. 12, (11) 1802-1815. 10.1016/j.celrep.2015.08.020

2014

Fossati-Jimack L, Ling GS, Baudino L, Szajna M, Manivannan K, Zhao JC, Midgley R, Chai J-G, Simpson E, Botto M and Scott D (2014). Intranasal peptide‐induced tolerance and linked suppression: consequences of complement deficiency. Wiley  Immunology  vol. 144, (1) 149-157. 10.1111/imm.12358
Banda NK, Mehta G, Chao Y, Wang G, Inturi S, Fossati-Jimack L, Botto M, Wu L, Moghimi SM and Simberg D (2014). Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum. Springer Nature  Particle and Fibre Toxicology  vol. 11, (1) 10.1186/s12989-014-0064-2
Sattler S, Ling G-S, Xu D, Hussaarts L, Romaine A, Zhao H, Fossati-Jimack L, Malik T, Cook HT, Botto M, Lau Y-L, Smits HH, Liew FY and Huang F-P (2014). IL-10-producing regulatory B cells induced by IL-33 (BregIL-33) effectively attenuate mucosal inflammatory responses in the gut. Elsevier  Journal of Autoimmunity  vol. 50, (100) 107-122. 10.1016/j.jaut.2014.01.032
Baudino L, Sardini A, Ruseva MM, Fossati-Jimack L, Cook HT, Scott D, Simpson E and Botto M (2014). C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 111, (4) 1503-1508. 10.1073/pnas.1316877111
Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G, Cook HT and Botto M (2014). Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages. Springer Nature  Nature Communications  vol. 5, (1) 10.1038/ncomms4039

2013

Fossati-Jimack L, Ling GS, Cortini A, Szajna M, Malik TH, McDonald JU, Pickering MC, Cook HT, Taylor PR and Botto M (2013). Phagocytosis Is the Main CR3-Mediated Function Affected by the Lupus-Associated Variant of CD11b in Human Myeloid Cells. Public Library of Science (Plos)  Plos One  vol. 8, (2) 10.1371/journal.pone.0057082

2012

Lewis MJ, Malik TH, Fossati‐Jimack L, Carassiti D, Cook HT, Haskard DO and Botto M (2012). Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia. Wiley  Arthritis & Rheumatism  vol. 64, (8) 2707-2718. 10.1002/art.34451

2011

Tarzi RM, Sharp PEH, McDaid JP, Fossati-Jimack L, Herbert PE, Pusey CD, Cook HT and Warrens AN (2011). Mice with defective Fas ligand are protected from crescentic glomerulonephritis. Elsevier  Kidney International  vol. 81, (2) 170-178. 10.1038/ki.2011.319
McDonald JU, Cortini A, Rosas M, Fossati‐Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K, Brown GD, Jones SA, Hallett MB, Botto M and Taylor PR (2011). In vivo functional analysis and genetic modification of in vitro‐derived mouse neutrophils. Wiley  The Faseb Journal  vol. 25, (6) 1972-1982. 10.1096/fj.10-178517

2010

Carlucci F, Fossati-Jimack L, Dumitriu IE, Heidari Y, Walport MJ, Szajna M, Baruah P, Garden OA, Cook HT and Botto M (2010). Identification and Characterization of a Lupus Suppressor 129 Locus on Chromosome 3. The American Association of Immunologists  The Journal of Immunology  vol. 184, (11) 6256-6265. 10.4049/jimmunol.0901463
Santiago-Raber M-L, Amano H, Amano E, Fossati-Jimack L, Swee LK, Rolink A and Izui S (2010). Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation. Elsevier  Journal of Autoimmunity  vol. 34, (4) 349-355. 10.1016/j.jaut.2010.01.001

2008

Heidari Y, Fossati-Jimack L, Carlucci F, Walport MJ, Cook HT and Botto M (2008). A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice. Springer Nature  Genes & Immunity  vol. 10, (1) 47-55. 10.1038/gene.2008.78
Baudino L, Yoshinobu K, Morito N, Kikuchi S, Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S, Jørgensen TN, Tucker RM, Roark CL, Kotzin BL, Evans LH and Izui S (2008). Dissection of Genetic Mechanisms Governing the Expression of Serum Retroviral gp70 Implicated in Murine Lupus Nephritis. The American Association of Immunologists  The Journal of Immunology  vol. 181, (4) 2846-2854. 10.4049/jimmunol.181.4.2846
FOSSATI L, MERINO J and IZUI S (2008). CD4+ T cells play a major role for IgM and IgG anti‐DNA production in mice infected with Plasmodium yoelii. Oxford University Press (Oup)  Clinical & Experimental Immunology  vol. 79, (2) 291-296. 10.1111/j.1365-2249.1990.tb05193.x
Fossati‐Jimack L, Cortes‐Hernandez J, Norsworthy PJ, Cook HT, Walport MJ and Botto M (2008). Regulation of B cell tolerance by 129‐derived chromosome 1 loci in C57BL/6 mice. Wiley  Arthritis & Rheumatism  vol. 58, (7) 2131-2141. 10.1002/art.23553

2007

Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Walport MJ, Cook HT and Botto M (2007). C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice. Elsevier  Molecular Immunology  vol. 45, (3) 787-795. 10.1016/j.molimm.2007.06.162
Baudino L, Fossati-Jimack L, Chevalley C, Martinez-Soria E, Shulman MJ and Izui S (2007). IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation. American Society of Hematology  Blood  vol. 109, (12) 5355-5362. 10.1182/blood-2006-11-059899
Carlucci F, Cortes-Hernandez J, Fossati-Jimack L, Bygrave AE, Walport MJ, Vyse TJ, Cook HT and Botto M (2007). Genetic Dissection of Spontaneous Autoimmunity Driven by 129-Derived Chromosome 1 Loci When Expressed on C57BL/6 Mice. The American Association of Immunologists  The Journal of Immunology  vol. 178, (4) 2352-2360. 10.4049/jimmunol.178.4.2352

2006

Kikuchi S, Santiago-Raber M-L, Amano H, Amano E, Fossati-Jimack L, Moll T, Kotzin BL and Izui S (2006). Contribution of NZB Autoimmunity 2 to Y-Linked Autoimmune Acceleration-Induced Monocytosis in Association with Murine Systemic Lupus. The American Association of Immunologists  The Journal of Immunology  vol. 176, (5) 3240-3247. 10.4049/jimmunol.176.5.3240

2005

Trendelenburg M, Fossati-Jimack L, Cortes-Hernandez J, Turnberg D, Lewis M, Izui S, Cook HT and Botto M (2005). The Role of Complement in Cryoglobulin-Induced Immune Complex Glomerulonephritis. The American Association of Immunologists  The Journal of Immunology  vol. 175, (10) 6909-6914. 10.4049/jimmunol.175.10.6909
Amano H, Amano E, Santiago‐Raber M, Moll T, Martinez‐Soria E, Fossati‐Jimack L, Iwamoto M, Rozzo SJ, Kotzin BL and Izui S (2005). Selective expansion of a monocyte subset expressing the CD11c dendritic cell marker in the Yaa model of systemic lupus erythematosus. Wiley  Arthritis & Rheumatism  vol. 52, (9) 2790-2798. 10.1002/art.21365
Tas SW, Quartier P, Botto M and Fossati-Jimack L (2005). Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells. Bmj  Annals of The Rheumatic Diseases  vol. 65, (2) 10.1136/ard.2005.037143
Kikuchi S, Amano H, Amano E, Fossati-Jimack L, Santiago-Raber M-L, Moll T, Ida A, Kotzin BL and Izui S (2005). Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice. American Society of Hematology  Blood  vol. 106, (4) 1323-1329. 10.1182/blood-2005-02-0558
Kikuchi S, Fossati-Jimack L, Moll T, Amano H, Amano E, Ida A, Ibnou-Zekri N, Laporte C, Santiago-Raber M-L, Rozzo SJ, Kotzin BL and Izui S (2005). Differential Role of Three Major New Zealand Black-Derived Loci Linked with Yaa-Induced Murine Lupus Nephritis. The American Association of Immunologists  The Journal of Immunology  vol. 174, (2) 1111-1117. 10.4049/jimmunol.174.2.1111

2004

Cortes‐Hernandez J, Fossati‐Jimack L, Petry F, Loos M, Izui S, Walport MJ, Cook HT and Botto M (2004). Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice. Wiley  European Journal of Immunology  vol. 34, (12) 3713-3722. 10.1002/eji.200425616
Haywood MEK, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Lewis MR, Fossati-Jimack L, Izui S, Walport MJ and Morley BJ (2004). Dissection of BXSB Lupus Phenotype Using Mice Congenic for Chromosome 1 Demonstrates That Separate Intervals Direct Different Aspects of Disease. The American Association of Immunologists  The Journal of Immunology  vol. 173, (7) 4277-4285. 10.4049/jimmunol.173.7.4277
Trendelenburg M, Manderson AP, Fossati‐Jimack L, Walport MJ and Botto M (2004). Monocytosis and accelerated activation of lymphocytes in C1q‐deficient autoimmune‐prone mice. Wiley  Immunology  vol. 113, (1) 80-88. 10.1111/j.1365-2567.2004.01940.x
LEE NJ, RIGBY RJ, GILL H, BOYLE JJ, FOSSATI‐JIMACK L, MORLEY BJ and VYSE TJ (2004). Multiple loci are linked with anti‐red blood cell antibody production in NZB mice − comparison with other phenotypes implies complex modes of action. Oxford University Press (Oup)  Clinical & Experimental Immunology  vol. 138, (1) 39-46. 10.1111/j.1365-2249.2004.02560.x
Kuroki A, Moll T, López‐Hoyos M, Fossati‐Jimack L, Ibnou‐Zekri N, Kikuchi S, Merino J, Merino R and Izui S (2004). Enforced Bcl‐2 expression in B lymphocytes induces rheumatoid factor and anti‐DNA production, but the Yaa mutation promotes only anti‐DNA production. Wiley  European Journal of Immunology  vol. 34, (4) 1077-1084. 10.1002/eji.200424859
Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ and Botto M (2004). Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells In Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis. The American Association of Immunologists  The Journal of Immunology  vol. 172, (6) 3406-3414. 10.4049/jimmunol.172.6.3406

2003

Lajaunias F, Ida A, Kikuchi S, Fossati‐Jimack L, Martinez‐Soria E, Moll T, Law C and Izui S (2003). Differential control of CD22 ligand expression on B and T lymphocytes, and enhanced expression in murine systemic lupus. Wiley  Arthritis & Rheumatism  vol. 48, (6) 1612-1621. 10.1002/art.11021

2002

Tarzi RM, Davies KA, Robson MG, Fossati-Jimack L, Saito T, Walport MJ and Cook HT (2002). Nephrotoxic nephritis is mediated by Fcγ receptors on circulating leukocytes and not intrinsic renal cells. Elsevier  Kidney International  vol. 62, (6) 2087-2096. 10.1046/j.1523-1755.2002.00687.x
CORTES‐HERNANDEZ J, FOSSATI‐JIMACK L, CARUGATI A, POTTER PK, WALPORT MJ, COOK HT and BOTTO M (2002). Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum‐mediated but complement‐independent mechanisms. Oxford University Press (Oup)  Clinical & Experimental Immunology  vol. 130, (3) 459-466. 10.1046/j.1365-2249.2002.01998.x
Kikuchi S, Pastore Y, Fossati-Jimack L, Kuroki A, Yoshida H, Fulpius T, Araki K, Takahashi S, Lemoine R, Reininger L and Izui S (2002). A Transgenic Mouse Model of Autoimmune Glomerulonephritis and Necrotizing Arteritis Associated with Cryoglobulinemia. The American Association of Immunologists  The Journal of Immunology  vol. 169, (8) 4644-4650. 10.4049/jimmunol.169.8.4644
Kuroki A, Kuroda Y, Kikuchi S, Lajaunias F, Fulpius T, Pastore Y, Fossati-Jimack L, Reininger L, Toda T, Nakata M, Kojima N, Mizuochi T and Izui S (2002). Level of galactosylation determines cryoglobulin activity of murine IgG3 monoclonal rheumatoid factor. American Society of Hematology  Blood  vol. 99, (8) 2922-2928. 10.1182/blood.v99.8.2922
da Silveira SA, Kikuchi S, Fossati-Jimack L, Moll T, Saito T, Verbeek JS, Botto M, Walport MJ, Carroll M and Izui S (2002). Complement Activation Selectively Potentiates the Pathogenicity of the IgG2b and IgG3 Isotypes of a High Affinity Anti-Erythrocyte Autoantibody. Rockefeller University Press  Journal of Experimental Medicine  vol. 195, (6) 665-672. 10.1084/jem.20012024
Mitchell DA, Pickering MC, Warren J, Fossati-Jimack L, Cortes-Hernandez J, Cook HT, Botto M and Walport MJ (2002). C1q Deficiency and Autoimmunity: The Effects of Genetic Background on Disease Expression. The American Association of Immunologists  The Journal of Immunology  vol. 168, (5) 2538-2543. 10.4049/jimmunol.168.5.2538
Fossati-Jimack L, da Silveira SA, Moll T, Kina T, Kuypers FA, Oldenborg P-A, Reininger L and Izui S (2002). Selective Increase of Autoimmune Epitope Expression on Aged Erythrocytes in Mice: Implications in Anti-erythrocyte Autoimmune Responses. Elsevier  Journal of Autoimmunity  vol. 18, (1) 17-25. 10.1006/jaut.2001.0563

2001

Izui S, Fossati-Jimack L, Azeredo da Silveira S and Moll T (2001). Isotype-dependent pathogenicity of autoantibodies: analysis in experimental autoimmune hemolytic anemia. Springer Nature  Seminars in Immunopathology  vol. 23, (4) 433-445. 10.1007/s281-001-8169-1
Mizuochi T, Pastore Y, Shikata K, Kuroki A, Kikuchi S, Fulpius T, Nakata M, Fossati-Jimack L, Reininger L, Matsushita M, Fujita T and Izui S (2001). Role of galactosylation in the renal pathogenicity of murine immunoglobulin G3 monoclonal cryoglobulins. American Society of Hematology  Blood  vol. 97, (11) 3537-3543. 10.1182/blood.v97.11.3537

2000

Chicheportiche Y, Fossati-Jimack L, Moll S, Ibnou-Zekri N and Izui S (2000). Down-Regulated Expression of TWEAK mRNA in Acute and Chronic Inflammatory Pathologies. Elsevier  Biochemical and Biophysical Research Communications  vol. 279, (1) 162-165. 10.1006/bbrc.2000.3913
Fossati-Jimack L, Ioan-Facsinay A, Reininger L, Chicheportiche Y, Watanabe N, Saito T, Hofhuis FMA, Gessner JE, Schiller C, Schmidt RE, Honjo T, Verbeek JS and Izui S (2000). Markedly Different Pathogenicity of Four Immunoglobulin G Isotype-Switch Variants of an Antierythrocyte Autoantibody Is Based on Their Capacity to Interact in Vivo with the Low-Affinity Fcγ Receptor III. Rockefeller University Press  Journal of Experimental Medicine  vol. 191, (8) 1293-1302. 10.1084/jem.191.8.1293
Hügin AW, Fossati-Jimack L and Izui S (2000). The Autoimmune Accelerating Yaa Mutation Does Not Accelerate Murine AIDS. Elsevier  Cellular Immunology  vol. 200, (2) 76-80. 10.1006/cimm.2000.1611
Izui S, Ibnou-Zekri N, Fossati-jimack L and Iwamoto M (2000). Lessons from BXSB and Related Mouse Models. Taylor & Francis  International Reviews of Immunology  vol. 19, (4-5) 447-472. 10.3109/08830180009055507

1999

Fossati-Jimack L, Reininger L, Chicheportiche Y, Clynes R, Ravetch JV, Honjo T and Izui S (1999). High Pathogenic Potential of Low-Affinity Autoantibodies in Experimental Autoimmune Hemolytic Anemia. Rockefeller University Press  Journal of Experimental Medicine  vol. 190, (11) 1689-1696. 10.1084/jem.190.11.1689

1997

Ibnou-Zekri N, Iwamoto M, Fossati L, McConahey PJ and Izui S (1997). Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice. Proceedings of The National Academy of Sciences  Proceedings of The National Academy of Sciences of The United States of America  vol. 94, (26) 14654-14659. 10.1073/pnas.94.26.14654
Santiago M-L, Fossati L, Jacquet C, Müller W, Izui S and Reininger L (1997). Interleukin-4 Protects against a Genetically Linked Lupus-like Autoimmune Syndrome. Rockefeller University Press  Journal of Experimental Medicine  vol. 185, (1) 65-70. 10.1084/jem.185.1.65

1996

Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T and Izui S (1996). Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. American Society For Clinical Investigation  Journal of Clinical Investigation  vol. 97, (7) 1597-1604. 10.1172/jci118584

1995

Fossati L, Sobel ES, Iwamoto M, Cohen PL, Eisenberg RA and Izui S (1995). The Yaa gene‐mediated acceleration of murine lupus: Yaa− T cells from non‐autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo. Wiley  European Journal of Immunology  vol. 25, (12) 3412-3417. 10.1002/eji.1830251231
Moll S, Menoud P-A, Fulpius T, Pastore Y, Takahashi S, Fossati L, Vassalli J-D, Sappino A-P, Schifferli JA and Izui S (1995). Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis. Elsevier  Kidney International  vol. 48, (5) 1459-1468. 10.1038/ki.1995.435
IZUI S, IWAMOTO M, FOSSATI U, MERINO R, TAKAHASHI S and IBNOU‐ZEKRI N (1995). The Yaa Gene Model of Systemic Lupus Erythematosus. Wiley  Immunological Reviews  vol. 144, (1) 137-156. 10.1111/j.1600-065x.1995.tb00068.x
Merino R, Fossati L, to MI, Takahashi S, Lemoine R, Ibnou-Zekri N, Pugliatti L, Merino J and Izui S (1995). Effect of Long-Term Anti-CD4 or Anti-CD8 Treatment on the Development oflprCD4−CD8−Double Negative T Cells and of the Autoimmune Syndrome in MRL-lpr/lprMice. Elsevier  Journal of Autoimmunity  vol. 8, (1) 33-45. 10.1006/jaut.1995.0003
Fossati L, Iwamoto M, Merino R and Izui S (1995). Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens. Wiley  European Journal of Immunology  vol. 25, (1) 166-173. 10.1002/eji.1830250128

1994

Izui S, Merino R, Iwamoto M and Fossati L (1994). Mechanisms of genetic control of murine systemic lupus erythematosus. Springer Nature  Seminars in Immunopathology  vol. 16, (2-3) 133-152. 10.1007/bf00197514
Herrera PL, Harlan DM, Fossati L, Izui S, Huarte J, Orci L, Vassalli JD and Vassalli P (1994). A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice. Springer Nature  Diabetologia  vol. 37, (12) 1277-1279. 10.1007/bf00399802
Fossati L, Merino R, Iwamoto M, Lemoine R and Izui S (1994). Lack of association of Vβ8+ T cells with lupus‐like syndrome in MRL‐lpr/lpr mice. Wiley  European Journal of Immunology  vol. 24, (7) 1717-1720. 10.1002/eji.1830240741
Izui S, Merino R, Fossati L and Iwamoto M (1994). The Role of the Yaa Gene in Lupus Syndrome. Taylor & Francis  International Reviews of Immunology  vol. 11, (3) 211-230. 10.3109/08830189409061728
IZUI S, BERNEY T, SHIBATA T, FULPIUS T, FOSSATI L and MERINO R (1994). Molecular and Cellular Basis for Pathogenicity of Autoantibodies. Tohoku University Medical Press  The Tohoku Journal of Experimental Medicine  vol. 173, (1) 10.1620/tjem.173.15

1993

Merino R, Iwamoto M, Fossati L, Muniesa P, Araki K, Takahashi S, Huarte J, Yamamura K, Vassalli JD and Izui S (1993). Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain. Rockefeller University Press  Journal of Experimental Medicine  vol. 178, (4) 1189-1197. 10.1084/jem.178.4.1189
Fossati L, Takahashi S, Merino R, Iwamoto M, Aubry J-P, Nose M, Spach C, Motta R and Izui S (1993). An MRL/MpJ-lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome. Oxford University Press (Oup)  International Immunology  vol. 5, (5) 525-532. 10.1093/intimm/5.5.525

1992

Merino R, Fossati L and Izui S (1992). The lupus-prone BXSB strain: the Yaa gene model of systemic lupus erythematosus. Springer Nature  Seminars in Immunopathology  vol. 14, (2) 141-157. 10.1007/bf00195291
Cerny A, Merino R, Fossati L, de Kossodo S, Heusser C, Waldvogel FA, Morse HC and Izui S (1992). Effect of cyclosporin A and zidovudine on immune abnormalities observed in the murine acquired immunodeficiency syndrome. Oxford University Press (Oup)  The Journal of Infectious Diseases  vol. 166, (2) 285-290. 10.1093/infdis/166.2.285
Merino R, Fossati L, Lacour M, Lemoine R, Higaki M and Izui S (1992). H‐2‐linked control of the Yaa gene‐induced acceleration of lupus‐like autoimmune disease in BXSB mice. Wiley  European Journal of Immunology  vol. 22, (2) 295-299. 10.1002/eji.1830220202

1991

Merino R, Fossati L, Lacour M and Izui S (1991). Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice. Rockefeller University Press  Journal of Experimental Medicine  vol. 174, (5) 1023-1029. 10.1084/jem.174.5.1023

1990

Reininger L, Shibata T, Schurmans S, Merino R, Fossati L, Lacour M and Izui S (1990). Spontaneous production of anti‐mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice. Wiley  European Journal of Immunology  vol. 20, (11) 2405-2410. 10.1002/eji.1830201107