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Dr Liliane Fossati-Jimack

Liliane Fossati-Jimack

Senior Scientific Officer

William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London
+44 (0)20 7882 8194




Synovial tissue explant in vitro culture


Publications of specific relevance to Predictive in vitro Models


Ferrari M, Onuoha SC, Fossati-Jimack L, Nerviani A, Alves PL, Pagani S, Deantonio C, Colombo F, Santoro C, Sblattero D and Pitzalis C (2021). Novel Bispecific Antibody for Synovial-Specific Target Delivery of Anti-TNF Therapy in Rheumatoid Arthritis. Frontiers in Immunology  vol. 12, 10.3389/fimmu.2021.640070
Jackson WD, Gulino A, Fossati-Jimack L, Castro Seoane R, Tian K, Best K, Köhl J, Belmonte B, Strid J and Botto M (2021). C3 Drives Inflammatory Skin Carcinogenesis Independently of C5. J Invest Dermatol  vol. 141, (2) 404-414.e6. 10.1016/j.jid.2020.06.025
Humby F, Durez P, Buch MH, Lewis MJ, Rizvi H, Rivellese F, Nerviani A, Giorli G, Mahto A, Montecucco C, Lauwerys B, Ng N, Ho P, Bombardieri M, Romão VC, Verschueren P, Kelly S, Sainaghi PP, Gendi N, Dasgupta B, Cauli A, Reynolds P, Cañete JD, Moots R, Taylor PC, Edwards CJ, Isaacs J, Sasieni P, Choy E and Pitzalis C (2021). Rituximab versus tocilizumab in anti-TNF inadequate responder patients with rheumatoid arthritis (R4RA): 16-week outcomes of a stratified, biopsy-driven, multicentre, open-label, phase 4 randomised controlled trial. The Lancet  vol. 397, (10271) 305-317. 10.1016/S0140-6736(20)32341-2


Pontarini E, Murray-Brown WJ, Croia C, Lucchesi D, Conway J, Rivellese F, Fossati-Jimack L, Astorri E, Prediletto E, Corsiero E, Romana Delvecchio F, Coleby R, Gelbhardt E, Bono A, Baldini C, Puxeddu I, Ruscitti P, Giacomelli R, Barone F, Fisher B, Bowman SJ, Colafrancesco S, Priori R, Sutcliffe N, Challacombe S, Carlesso G, Tappuni A, Pitzalis C and Bombardieri M (2020). Unique expansion of IL-21+ Tfh and Tph cells under control of ICOS identifies Sjögren's syndrome with ectopic germinal centres and MALT lymphoma. Annals of The Rheumatic Diseases  vol. 79, (12) 1588-1599. 10.1136/annrheumdis-2020-217646
Rivellese F, Humby F, Bugatti S, Fossati-Jimack L, Rizvi H, Lucchesi D, Lliso-Ribera G, Nerviani A, Hands RE, Giorli G, Frias B, Thorborn G, Jaworska E, John C, Goldmann K, Lewis MJ, Manzo A, Bombardieri M, Pitzalis C and PEAC- R4RA investigators (2020). B cell synovitis and clinical phenotypes in rheumatoid arthritis: relationship to disease stages and drug exposure. Wiley  Arthritis and Rheumatology  10.1002/art.41184


El Shikh MEM, El Sayed R, Nerviani A, Goldmann K, John CR, Hands R, Fossati-Jimack L, Lewis MJ and Pitzalis C (2019). Extracellular traps and PAD4 released by macrophages induce citrullination and auto-antibody production in autoimmune arthritis. Elsevier Bv  Journal of Autoimmunity  10.1016/j.jaut.2019.06.008
Pontarini E, Lucchesi D, Fossati-Jimack L, Coleby R, Tentorio P, Croia C, Bombardieri M and Mavilio D (2019). NK cell recruitment in salivary glands provides early viral control but is dispensable for tertiary lymphoid structure formation. Journal of Leukocyte Biology  vol. 105, (3) 589-602. 10.1002/JLB.5A1117-462RR


Cope AP, Barnes MR, Belson A, Binks M, Brockbank S, Bonachela-Capdevila F, Carini C, Fisher BA, Goodyear CS, Emery P, Ehrenstein MR, Gozzard N, Harris R, Hollis S, Keidel S, Levesque M, Lindholm C, McDermott MF, McInnes IB, Mela CM, Parker G, Read S, Pedersen AW, Ponchel F, Porter D, Rao R, Rowe A, Schulz-Knappe P, Sleeman MA and Symmons D (2018). The RA-MAP Consortium: a working model for academia-industry collaboration. Nat Rev Rheumatol  vol. 14, (1) 53-60. 10.1038/nrrheum.2017.200
Rivellese F, Mauro D, Nerviani A, Pagani S, Fossati-Jimack L, Messemaker T, Kurreeman FAS, Toes REM, Ramming A, Rauber S, Schett G, Jones GW, Jones SA, Rossi FW, De Paulis A, Marone G, El Shikh MEM, Humby F and Pitzalis C (2018). Mast cells in early rheumatoid arthritis associate with disease severity and support B cell autoantibody production. Annals of The Rheumatic Diseases  vol. 77, (12) 1773-1781. 10.1136/annrheumdis-2018-213418


Barbour TD, Ling GS, Ruseva MM, Fossati-Jimack L, Cook HT, Botto M and Pickering MC (2016). Complement receptor 3 mediates renal protection in experimental C3 glomerulopathy. Kidney Int  vol. 89, (4) 823-832. 10.1016/j.kint.2015.11.024


Saja MF, Baudino L, Jackson WD, Cook HT, Malik TH, Fossati-Jimack L, Ruseva M, Pickering MC, Woollard KJ and Botto M (2015). Triglyceride-Rich Lipoproteins Modulate the Distribution and Extravasation of Ly6C/Gr1(low) Monocytes. Cell Rep  vol. 12, (11) 1802-1815. 10.1016/j.celrep.2015.08.020
Fossati-Jimack L, Ling GS, Baudino L, Szajna M, Manivannan K, Zhao JC, Midgley R, Chai J-G, Simpson E, Botto M and Scott D (2015). Intranasal peptide-induced tolerance and linked suppression: consequences of complement deficiency. Immunology  vol. 144, (1) 149-157. 10.1111/imm.12358


Banda NK, Mehta G, Chao Y, Wang G, Inturi S, Fossati-Jimack L, Botto M, Wu L, Moghimi SM and Simberg D (2014). Mechanisms of complement activation by dextran-coated superparamagnetic iron oxide (SPIO) nanoworms in mouse versus human serum. Part Fibre Toxicol  vol. 11, 10.1186/s12989-014-0064-2
Sattler S, Ling G-S, Xu D, Hussaarts L, Romaine A, Zhao H, Fossati-Jimack L, Malik T, Cook HT, Botto M, Lau Y-L, Smits HH, Liew FY and Huang F-P (2014). IL-10-producing regulatory B cells induced by IL-33 (Breg(IL-33)) effectively attenuate mucosal inflammatory responses in the gut. J Autoimmun  vol. 50, 107-122. 10.1016/j.jaut.2014.01.032
Baudino L, Sardini A, Ruseva MM, Fossati-Jimack L, Cook HT, Scott D, Simpson E and Botto M (2014). C3 opsonization regulates endocytic handling of apoptotic cells resulting in enhanced T-cell responses to cargo-derived antigens. Proc Natl Acad Sci U S A  vol. 111, (4) 1503-1508. 10.1073/pnas.1316877111
Ling GS, Bennett J, Woollard KJ, Szajna M, Fossati-Jimack L, Taylor PR, Scott D, Franzoso G, Cook HT and Botto M (2014). Integrin CD11b positively regulates TLR4-induced signalling pathways in dendritic cells but not in macrophages. Nat Commun  vol. 5, 10.1038/ncomms4039


Fossati-Jimack L, Ling GS, Cortini A, Szajna M, Malik TH, McDonald JU, Pickering MC, Cook HT, Taylor PR and Botto M (2013). Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. Plos One  vol. 8, (2) 10.1371/journal.pone.0057082


Lewis MJ, Malik TH, Fossati-Jimack L, Carassiti D, Cook HT, Haskard DO and Botto M (2012). Distinct roles for complement in glomerulonephritis and atherosclerosis revealed in mice with a combination of lupus and hyperlipidemia. Arthritis and Rheumatism  vol. 64, (8) 2707-2718. 10.1002/art.34451
Tarzi RM, Sharp PEH, McDaid JP, Fossati-Jimack L, Herbert PE, Pusey CD, Cook HT and Warrens AN (2012). Mice with defective Fas ligand are protected from crescentic glomerulonephritis. Kidney Int  vol. 81, (2) 170-178. 10.1038/ki.2011.319


McDonald JU, Cortini A, Rosas M, Fossati-Jimack L, Ling GS, Lewis KJ, Dewitt S, Liddiard K, Brown GD, Jones SA, Hallett MB, Botto M and Taylor PR (2011). In vivo functional analysis and genetic modification of in vitro-derived mouse neutrophils. Faseb J  vol. 25, (6) 1972-1982. 10.1096/fj.10-178517


Santiago-Raber M-L, Amano H, Amano E, Fossati-Jimack L, Swee LK, Rolink A and Izui S (2010). Evidence that Yaa-induced loss of marginal zone B cells is a result of dendritic cell-mediated enhanced activation. J Autoimmun  vol. 34, (4) 349-355. 10.1016/j.jaut.2010.01.001
Carlucci F, Fossati-Jimack L, Dumitriu IE, Heidari Y, Walport MJ, Szajna M, Baruah P, Garden OA, Cook HT and Botto M (2010). Identification and characterization of a lupus suppressor 129 locus on chromosome 3. J Immunol  vol. 184, (11) 6256-6265. 10.4049/jimmunol.0901463


Heidari Y, Fossati-Jimack L, Carlucci F, Walport MJ, Cook HT and Botto M (2009). A lupus-susceptibility C57BL/6 locus on chromosome 3 (Sle18) contributes to autoantibody production in 129 mice. Genes Immun  vol. 10, (1) 47-55. 10.1038/gene.2008.78


Baudino L, Yoshinobu K, Morito N, Kikuchi S, Fossati-Jimack L, Morley BJ, Vyse TJ, Hirose S, Jørgensen TN, Tucker RM, Roark CL, Kotzin BL, Evans LH and Izui S (2008). Dissection of genetic mechanisms governing the expression of serum retroviral gp70 implicated in murine lupus nephritis. J Immunol  vol. 181, (4) 2846-2854. 10.4049/jimmunol.181.4.2846
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Cook HT, Walport MJ and Botto M (2008). Regulation of B cell tolerance by 129-derived chromosome 1 loci in C57BL/6 mice. Arthritis Rheum  vol. 58, (7) 2131-2141. 10.1002/art.23553
Fossati-Jimack L, Cortes-Hernandez J, Norsworthy PJ, Walport MJ, Cook HT and Botto M (2008). C1q deficiency promotes the production of transgenic-derived IgM and IgG3 autoantibodies in anti-DNA knock-in transgenic mice. Mol Immunol  vol. 45, (3) 787-795. 10.1016/j.molimm.2007.06.162


Baudino L, Fossati-Jimack L, Chevalley C, Martinez-Soria E, Shulman MJ and Izui S (2007). IgM and IgA anti-erythrocyte autoantibodies induce anemia in a mouse model through multivalency-dependent hemagglutination but not through complement activation. Blood  vol. 109, (12) 5355-5362. 10.1182/blood-2006-11-059899
Carlucci F, Cortes-Hernandez J, Fossati-Jimack L, Bygrave AE, Walport MJ, Vyse TJ, Cook HT and Botto M (2007). Genetic dissection of spontaneous autoimmunity driven by 129-derived chromosome 1 Loci when expressed on C57BL/6 mice. J Immunol  vol. 178, (4) 2352-2360. 10.4049/jimmunol.178.4.2352


Kikuchi S, Santiago-Raber M-L, Amano H, Amano E, Fossati-Jimack L, Moll T, Kotzin BL and Izui S (2006). Contribution of NZB autoimmunity 2 to Y-linked autoimmune acceleration-induced monocytosis in association with murine systemic lupus. J Immunol  vol. 176, (5) 3240-3247. 10.4049/jimmunol.176.5.3240
Tas SW, Quartier P, Botto M and Fossati-Jimack L (2006). Macrophages from patients with SLE and rheumatoid arthritis have defective adhesion in vitro, while only SLE macrophages have impaired uptake of apoptotic cells. Ann Rheum Dis  vol. 65, (2) 216-221. 10.1136/ard.2005.037143


Trendelenburg M, Fossati-Jimack L, Cortes-Hernandez J, Turnberg D, Lewis M, Izui S, Cook HT and Botto M (2005). The role of complement in cryoglobulin-induced immune complex glomerulonephritis. J Immunol  vol. 175, (10) 6909-6914. 10.4049/jimmunol.175.10.6909
Amano H, Amano E, Santiago-Raber M-L, Moll T, Martinez-Soria E, Fossati-Jimack L, Iwamoto M, Rozzo SJ, Kotzin BL and Izui S (2005). Selective expansion of a monocyte subset expressing the CD11c dendritic cell marker in the Yaa model of systemic lupus erythematosus. Arthritis Rheum  vol. 52, (9) 2790-2798. 10.1002/art.21365
Kikuchi S, Amano H, Amano E, Fossati-Jimack L, Santiago-Raber M-L, Moll T, Ida A, Kotzin BL and Izui S (2005). Identification of 2 major loci linked to autoimmune hemolytic anemia in NZB mice. Blood  vol. 106, (4) 1323-1329. 10.1182/blood-2005-02-0558
Kikuchi S, Fossati-Jimack L, Moll T, Amano H, Amano E, Ida A, Ibnou-Zekri N, Laporte C, Santiago-Raber M-L, Rozzo SJ, Kotzin BL and Izui S (2005). Differential role of three major New Zealand Black-derived loci linked with Yaa-induced murine lupus nephritis. J Immunol  vol. 174, (2) 1111-1117. 10.4049/jimmunol.174.2.1111


Cortes-Hernandez J, Fossati-Jimack L, Petry F, Loos M, Izui S, Walport MJ, Cook HT and Botto M (2004). Restoration of C1q levels by bone marrow transplantation attenuates autoimmune disease associated with C1q deficiency in mice. Eur J Immunol  vol. 34, (12) 3713-3722. 10.1002/eji.200425616
Haywood MEK, Rogers NJ, Rose SJ, Boyle J, McDermott A, Rankin JM, Thiruudaian V, Lewis MR, Fossati-Jimack L, Izui S, Walport MJ and Morley BJ (2004). Dissection of BXSB lupus phenotype using mice congenic for chromosome 1 demonstrates that separate intervals direct different aspects of disease. Journal of Immunology  vol. 173, (7) 4277-4285. 10.4049/jimmunol.173.7.4277
Lee NJ, Rigby RJ, Gill H, Boyle JJ, Fossati-Jimack L, Morley BJ and Vyse TJ (2004). Multiple loci are linked with anti-red blood cell antibody production in NZB mice -- comparison with other phenotypes implies complex modes of action. Clin Exp Immunol  vol. 138, (1) 39-46. 10.1111/j.1365-2249.2004.02560.x
Trendelenburg M, Manderson AP, Fossati-Jimack L, Walport MJ and Botto M (2004). Monocytosis and accelerated activation of lymphocytes in C1q-deficient autoimmune-prone mice. Immunology  vol. 113, (1) 80-88. 10.1111/j.1365-2567.2004.01940.x
Kuroki A, Moll T, López-Hoyos M, Fossati-Jimack L, Ibnou-Zekri N, Kikuchi S, Merino J, Merino R and Izui S (2004). Enforced Bcl-2 expression in B lymphocytes induces rheumatoid factor and anti-DNA production, but the Yaa mutation promotes only anti-DNA production. Eur J Immunol  vol. 34, (4) 1077-1084. 10.1002/eji.200424859
Norsworthy PJ, Fossati-Jimack L, Cortes-Hernandez J, Taylor PR, Bygrave AE, Thompson RD, Nourshargh S, Walport MJ and Botto M (2004). Murine CD93 (C1qRp) Contributes to the Removal of Apoptotic Cells in Vivo but Is Not Required for C1q-Mediated Enhancement of Phagocytosis. Journal of Immunology  vol. 172, (6) 3406-3414. 10.4049/jimmunol.172.6.3406


Lajaunias F, Ida A, Kikuchi S, Fossati-Jimack L, Martinez-Soria E, Moll T, Law C-L and Izui S (2003). Differential control of CD22 ligand expression on B and T lymphocytes, and enhanced expression in murine systemic lupus. Arthritis Rheum  vol. 48, (6) 1612-1621. 10.1002/art.11021


Tarzi RM, Davies KA, Robson MG, Fossati-Jimack L, Saito T, Walport MJ and Cook HT (2002). Nephrotoxic nephritis is mediated by Fcgamma receptors on circulating leukocytes and not intrinsic renal cells. Kidney Int  vol. 62, (6) 2087-2096. 10.1046/j.1523-1755.2002.00687.x
Cortes-Hernandez J, Fossati-Jimack L, Carugati A, Potter PK, Walport MJ, Cook HT and Botto M (2002). Murine glomerular mesangial cell uptake of apoptotic cells is inefficient and involves serum-mediated but complement-independent mechanisms. Clin Exp Immunol  vol. 130, (3) 459-466. 10.1046/j.1365-2249.2002.01998.x
Kikuchi S, Pastore Y, Fossati-Jimack L, Kuroki A, Yoshida H, Fulpius T, Araki K, Takahashi S, Lemoine R, Reininger L and Izui S (2002). A transgenic mouse model of autoimmune glomerulonephritis and necrotizing arteritis associated with cryoglobulinemia. J Immunol  vol. 169, (8) 4644-4650. 10.4049/jimmunol.169.8.4644
Kuroki A, Kuroda Y, Kikuchi S, Lajaunias F, Fulpius T, Pastore Y, Fossati-Jimack L, Reininger L, Toda T, Nakata M, Kojima N, Mizuochi T and Izui S (2002). Level of galactosylation determines cryoglobulin activity of murine IgG3 monoclonal rheumatoid factor. Blood  vol. 99, (8) 2922-2928. 10.1182/blood.v99.8.2922
Azeredo da Silveira S, Kikuchi S, Fossati-Jimack L, Moll T, Saito T, Verbeek JS, Botto M, Walport MJ, Carroll M and Izui S (2002). Complement activation selectively potentiates the pathogenicity of the IgG2b and IgG3 isotypes of a high affinity anti-erythrocyte autoantibody. J Exp Med  vol. 195, (6) 665-672. 10.1084/jem.20012024
Mitchell DA, Pickering MC, Warren J, Fossati-Jimack L, Cortes-Hernandez J, Cook HT, Botto M and Walport MJ (2002). C1q deficiency and autoimmunity: the effects of genetic background on disease expression. J Immunol  vol. 168, (5) 2538-2543. 10.4049/jimmunol.168.5.2538
Fossati-Jimack L, Azeredo da Silveira S, Moll T, Kina T, Kuypers FA, Oldenborg P-A, Reininger L and Izui S (2002). Selective increase of autoimmune epitope expression on aged erythrocytes in mice: implications in anti-erythrocyte autoimmune responses. J Autoimmun  vol. 18, (1) 17-25. 10.1006/jaut.2001.0563


Izui S, Fossati-Jimack L, da Silveira SA and Moll T (2001). Isotype-dependent pathogenicity of autoantibodies: analysis in experimental autoimmune hemolytic anemia. Springer Semin Immunopathol  vol. 23, (4) 433-445. 10.1007/s281-001-8169-1
Mizuochi T, Pastore Y, Shikata K, Kuroki A, Kikuchi S, Fulpius T, Nakata M, Fossati-Jimack L, Reininger L, Matsushita M, Fujita T and Izui S (2001). Role of galactosylation in the renal pathogenicity of murine immunoglobulin G3 monoclonal cryoglobulins. Blood  vol. 97, (11) 3537-3543. 10.1182/blood.v97.11.3537


Chicheportiche Y, Fossati-Jimack L, Moll S, Ibnou-Zekri N and Izui S (2000). Down-regulated expression of TWEAK mRNA in acute and chronic inflammatory pathologies. Biochem Biophys Res Commun  vol. 279, (1) 162-165. 10.1006/bbrc.2000.3913
Fossati-Jimack L, Ioan-Facsinay A, Reininger L, Chicheportiche Y, Watanabe N, Saito T, Hofhuis FM, Gessner JE, Schiller C, Schmidt RE, Honjo T, Verbeek JS and Izui S (2000). Markedly different pathogenicity of four immunoglobulin G isotype-switch variants of an antierythrocyte autoantibody is based on their capacity to interact in vivo with the low-affinity Fcgamma receptor III. J Exp Med  vol. 191, (8) 1293-1302. 10.1084/jem.191.8.1293
Hügin AW, Fossati-Jimack L and Izui S (2000). The autoimmune accelerating yaa mutation does not accelerate murine AIDS. Cell Immunol  vol. 200, (2) 76-80. 10.1006/cimm.2000.1611
Izui S, Ibnou-Zekri N, Fossati-Jimack L and Iwamoto M (2000). Lessons from BXSB and related mouse models. Int Rev Immunol  vol. 19, (4-5) 447-472. 10.3109/08830180009055507


Fossati-Jimack L, Reininger L, Chicheportiche Y, Clynes R, Ravetch JV, Honjo T and Izui S (1999). High pathogenic potential of low-affinity autoantibodies in experimental autoimmune hemolytic anemia. J Exp Med  vol. 190, (11) 1689-1696. 10.1084/jem.190.11.1689


Ibnou-Zekri N, Iwamoto M, Fossati L, McConahey PJ and Izui S (1997). Role of the major histocompatibility complex class II Ea gene in lupus susceptibility in mice. Proc Natl Acad Sci U S A  vol. 94, (26) 14654-14659. 10.1073/pnas.94.26.14654
Santiago ML, Fossati L, Jacquet C, Müller W, Izui S and Reininger L (1997). Interleukin-4 protects against a genetically linked lupus-like autoimmune syndrome. J Exp Med  vol. 185, (1) 65-70. 10.1084/jem.185.1.65


Takahashi S, Fossati L, Iwamoto M, Merino R, Motta R, Kobayakawa T and Izui S (1996). Imbalance towards Th1 predominance is associated with acceleration of lupus-like autoimmune syndrome in MRL mice. J Clin Invest  vol. 97, (7) 1597-1604. 10.1172/JCI118584


Fossati L, Sobel ES, Iwamoto M, Cohen PL, Eisenberg RA and Izui S (1995). The Yaa gene-mediated acceleration of murine lupus: Yaa- T cells from non-autoimmune mice collaborate with Yaa+ B cells to produce lupus autoantibodies in vivo. Eur J Immunol  vol. 25, (12) 3412-3417. 10.1002/eji.1830251231
Moll S, Menoud PA, Fulpius T, Pastore Y, Takahashi S, Fossati L, Vassalli JD, Sappino AP, Schifferli JA and Izui S (1995). Induction of plasminogen activator inhibitor type 1 in murine lupus-like glomerulonephritis. Kidney Int  vol. 48, (5) 1459-1468. 10.1038/ki.1995.435
Izui S, Iwamoto M, Fossati L, Merino R, Takahashi S and Ibnou-Zekri N (1995). The Yaa gene model of systemic lupus erythematosus. Immunol Rev  vol. 144, 137-156. 10.1111/j.1600-065x.1995.tb00068.x
Merino R, Fossati L, Iwamoto M, Takahashi S, Lemoine R, Ibnou-Zekri N, Pugliatti L, Merino J and Izui S (1995). Effect of long-term anti-CD4 or anti-CD8 treatment on the development of lpr CD4- CD8- double negative T cells and of the autoimmune syndrome in MRL-lpr/lpr mice. J Autoimmun  vol. 8, (1) 33-45. 10.1006/jaut.1995.0003
Fossati L, Iwamoto M, Merino R and Izui S (1995). Selective enhancing effect of the Yaa gene on immune responses against self and foreign antigens. Eur J Immunol  vol. 25, (1) 166-173. 10.1002/eji.1830250128


Herrera PL, Harlan DM, Fossati L, Izui S, Huarte J, Orci L, Vassalli JD and Vassalli P (1994). A CD8+ T-lymphocyte-mediated and CD4+ T-lymphocyte-independent autoimmune diabetes of early onset in transgenic mice. Diabetologia  vol. 37, (12) 1277-1279. 10.1007/BF00399802
Fossati L, Merino R, Iwamoto M, Lemoine R and Izui S (1994). Lack of association of V beta 8+ T cells with lupus-like syndrome in MRL-lpr/lpr mice. Eur J Immunol  vol. 24, (7) 1717-1720. 10.1002/eji.1830240741
Izui S, Berney T, Shibata T, Fulpius T, Fossati L and Merino R (1994). Molecular and cellular basis for pathogenicity of autoantibodies. Tohoku J Exp Med  vol. 173, (1) 15-30. 10.1620/tjem.173.15
Izui S, Merino R, Fossati L and Iwamoto M (1994). The role of the Yaa gene in lupus syndrome. Int Rev Immunol  vol. 11, (3) 211-230. 10.3109/08830189409061728
Izui S, Merino R, Iwamoto M and Fossati L (1994). Mechanisms of genetic control of murine systemic lupus erythematosus. Springer Semin Immunopathol  vol. 16, (2-3) 133-152. 10.1007/BF00197514


Merino R, Iwamoto M, Fossati L, Muniesa P, Araki K, Takahashi S, Huarte J, Yamamura K, Vassalli JD and Izui S (1993). Prevention of systemic lupus erythematosus in autoimmune BXSB mice by a transgene encoding I-E alpha chain. J Exp Med  vol. 178, (4) 1189-1197. 10.1084/jem.178.4.1189
Fossati L, Takahashi S, Merino R, Iwamoto M, Aubry JP, Nose M, Spach C, Motta R and Izui S (1993). An MRL/MpJ-lpr/lpr substrain with a limited expansion of lpr double-negative T cells and a reduced autoimmune syndrome. Int Immunol  vol. 5, (5) 525-532. 10.1093/intimm/5.5.525


Cerny A, Merino R, Fossati L, de Kossodo S, Heusser C, Waldvogel FA, Morse HC and Izui S (1992). Effect of cyclosporin A and zidovudine on immune abnormalities observed in the murine acquired immunodeficiency syndrome. J Infect Dis  vol. 166, (2) 285-290. 10.1093/infdis/166.2.285
Merino R, Fossati L, Lacour M, Lemoine R, Higaki M and Izui S (1992). H-2-linked control of the Yaa gene-induced acceleration of lupus-like autoimmune disease in BXSB mice. Eur J Immunol  vol. 22, (2) 295-299. 10.1002/eji.1830220202
Merino R, Fossati L and Izui S (1992). The lupus-prone BXSB strain: the Yaa gene model of systemic lupus erythematosus. Springer Semin Immunopathol  vol. 14, (2) 141-157. 10.1007/BF00195291


Merino R, Fossati L, Lacour M and Izui S (1991). Selective autoantibody production by Yaa+ B cells in autoimmune Yaa(+)-Yaa- bone marrow chimeric mice. J Exp Med  vol. 174, (5) 1023-1029. 10.1084/jem.174.5.1023


Reininger L, Shibata T, Schurmans S, Merino R, Fossati L, Lacour M and Izui S (1990). Spontaneous production of anti-mouse red blood cell autoantibodies is independent of the polyclonal activation in NZB mice. Eur J Immunol  vol. 20, (11) 2405-2410. 10.1002/eji.1830201107
Fossati L, Merino J and Izui S (1990). CD4+ T cells play a major role for IgM and IgG anti-DNA production in mice infected with Plasmodium yoelii. Clin Exp Immunol  vol. 79, (2) 291-296. 10.1111/j.1365-2249.1990.tb05193.x