Publications

Publications of specific relevance to Predictive in vitro Models
2019

Meyre D, Andress EJ, Sharma T, Snippe M, Asif H, Maharaj A, Vatin V, Gaget S, Besnard P, Choquet H, Froguel P and
Linton KJ (2019).
Contribution of rare coding mutations in CD36 to type 2 diabetes and cardio-metabolic complications. Scientific Reports vol. 9, (1)
10.1038/s41598-019-53388-8
Adamska A, Domenichini A, Capone E, Damiani V, Akkaya BG,
Linton KJ, Di Sebastiano P, Chen X, Keeton AB, Ramirez-Alcantara V, Maxuitenko Y, Piazza GA, De Laurenzi V, Sala G and Falasca M (2019).
Pharmacological inhibition of ABCC3 slows tumour progression in animal models of pancreatic cancer. Journal of Experimental and Clinical Cancer Research vol. 38, (1)
10.1186/s13046-019-1308-7
Adamska A, Ferro R, Lattanzio R, Capone E, Domenichini A, Damiani V, Chiorino G, Akkaya BG,
Linton KJ, De Laurenzi V, Sala G and Falasca M (2019).
ABCC3 is a novel target for the treatment of pancreatic cancer. Advances in Biological Regulation vol. 73,
10.1016/j.jbior.2019.04.004
Kawecki C, Bocquet O, Schmelzer CEH, Heinz A, Ihling C, Wahart A, Romier B, Bennasroune A, Blaise S, Terryn C,
Linton KJ, Martiny L, Duca L and Maurice P (2019).
Identification of CD36 as a new interaction partner of membrane NEU1: potential implication in the pro-atherogenic effects of the elastin receptor complex. Cellular and Molecular Life Sciences vol. 76, (4) 791-807.
10.1007/s00018-018-2978-62018

Rahman MM, Hazan A, Selway JL, Herath DS, Harwood CA, Pirzado MS, Atkar R,
Kelsell DP,
Linton KJ, Philpott MP and Neill GW (2018).
A novel mechanism for activation of GLI1 by nuclear SMO that escapes anti-SMO inhibitors. Cancer Research vol. 78, (10) 2577-2588.
10.1158/0008-5472.CAN-17-28972017

Andress EJ, Nicolaou M, McGeoghan F and
Linton KJ (2017).
ABCB4 missense mutations D243A, K435T, G535D, I490T, R545C, and S978P significantly impair the lipid floppase and likely predispose to secondary pathologies in the human population. Cell Mol Life Sci 10.1007/s00018-017-2472-62015

Akkaya BG, Zolnerciks JK, Ritchie TK, Bauer B, Hartz AMS, Sullivan JA and
Linton KJ (2015).
The multidrug resistance pump ABCB1 is a substrate for the ubiquitin ligase NEDD4-1. Molecular Membrane Biology vol. 32, (2) 39-45.
10.3109/09687688.2015.10233782014

Sanders D, Zampronio CG, Nettleship JE, Owens RJ, Owen C and
Linton KJ (2014).
Characterisation of the scavenger receptor CD36. Biochemistry and Cell Biology-Biochimie Et Biologie Cellulaire vol. 92, (6) 587-587.

Zolnerciks JK, Akkaya BG, Snippe M, Chiba P, Seelig A and
Linton KJ (2014).
The Q loops of the human multidrug resistance transporter ABCB1 are necessary to couple drug binding to the ATP catalytic cycle. Faseb J vol. 28, (10) 4335-4346.
10.1096/fj.13-245639
Janha RE, Worwui A,
Linton KJ, Shaheen SO, Sisay-Joof F and Walton RT (2014).
Inactive alleles of cytochrome P450 2C19 may be positively selected in human evolution. Bmc Evol Biol vol. 14,
10.1186/1471-2148-14-712013

Blaydon DC#22026#, Lind LK, Plagnol V, Linton KJ#25163#, Smith FJD, Wilson NJ, McLean WHI, Munro CS, South AP, Leigh IM#20814#, O'Toole EA#20462#, Lundström A and Kelsell DP#20941# (2013).
Mutations in AQP5, encoding a water-channel protein, cause autosomal-dominant diffuse nonepidermolytic palmoplantar keratoderma. Am J Hum Genet vol. 93, (2) 330-335.
10.1016/j.ajhg.2013.06.008
Andress EJ, Nicolaou M, Romero MR, Naik S, Dixon PH, Williamson C and
Linton KJ (2013).
A molecular mechanistic explanation for the spectrum of cholestatic disease caused by the S320F variant of ABCB4. Wiley Online Hepatology 10.1002/hep.269702012

Nicolaou M, Andress EJ, Zolnerciks JK, Dixon PH, Williamson C and
Linton KJ (2012).
Canalicular ABC transporters and liver disease. J Pathol vol. 226, (2) 300-315.
10.1002/path.30192011

Groen A, Romero MR, Kunne C, Hoosdally SJ, Dixon PH, Wooding C, Williamson C, Seppen J, Van den Oever K, Mok KS, Paulusma CC,
Linton KJ and Oude Elferink RPJ (2011).
Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity. Gastroenterology vol. 141, (5)
10.1053/j.gastro.2011.07.042
Zolnerciks JK, Andress EJ, Nicolaou M and
Linton KJ (2011).
Structure of ABC transporters. Essays Biochem vol. 50, (1) 43-61.
10.1042/bse0500043
Linton KJ, Zolnerciks JK and Schmitt L (2011).
General Introduction, Structure and Likely Mechanism of Action of ABC Transport Proteins. The Abc Transporters of Human Physiology and Disease: Genetics and Biochemistry of Atp Binding Cassette Transporters , Editors: Linton KJ and Holland IB.
World Scientific Publishing 10.1142/9789814280075_0001
Linton KJ and Holland IB (2011).
The ABC transporters of human physiology and disease: Genetics and biochemistry of atp binding cassette transporters. 10.1142/73712009

Hoosdally SJ, Andress EJ, Wooding C, Martin CA and
Linton KJ (2009).
The Human Scavenger Receptor CD36 GLYCOSYLATION STATUS AND ITS ROLE IN TRAFFICKING AND FUNCTION. J Biol Chem vol. 284, (24) 16277-16288.
10.1074/jbc.M109.007849
Dixon PH, van Mil SWC, Chambers J, Strautnieks S, Thompson RJ, Lammert F, Kubitz R, Keitel V, Glantz A, Mattsson LA, Marschall HU, Molokhia M, Moore GE,
Linton KJ and Williamson C (2009).
Contribution of variant alleles of ABCB11 to susceptibility to intrahepatic cholestasis of pregnancy. Gut vol. 58, (4) 537-544.
10.1136/gut.2008.159541
Byrne JA, Strautnieks SS, Ihrke G, Pagani F, Kinsely AS,
Linton KJ, Mieli-Vergani G and Thompson RJ (2009).
Missense Mutations and Single Nucleotide Polymorphisms in ABCB11 Impair Bile Salt Export Pump Processing and Function or Disrupt Pre-Messenger RNA Splicing. Hepatology vol. 49, (2) 553-567.
10.1002/hep.226832007

Zolnerciks JK, Wooding C and
Linton KJ (2007).
Evidence for a Sav1866-like architecture for the human multidrug transporter P-glycoprotein. Faseb J vol. 21, (14) 3937-3948.
10.1096/fj.07-8610com
Martin CA, Longman E, Wooding C, Hoosdally SJ, Ali S, Aitman TJ, Gutmann DAP, Freemont PS, Byrne B and
Linton KJ (2007).
Cd36, a class B scavenger receptor, functions as a monomer to bind acetylated and oxidized low-density lipoproteins. Protein Sci vol. 16, (11) 2531-2541.
10.1110/ps.073007207
Linton KJ and Higgins CF (2007).
Structure and function of ABC transporters: the ATP switch provides flexible control. Pflug Arch Eur J Phy vol. 453, (5) 555-567.
10.1007/s00424-006-0126-x2005

Elliott JI, Surprenant A, Marelli-Berg FM, Cooper JC, Cassady-Cain RL, Wooding C,
Linton KJ, Alexander DR and Higgins CF (2005).
Membrane phosphatidylserine distribution as a non-apoptotic signalling mechanism in lymphocytes. Nat. Cell Biol. vol. 7, 808-816.
10.1038/ncb12792004

Lepretre F,
Linton KJ, Lacquemant C, Vatin V, Samson C, Dina C, Chikri M, Ali S, Scherer P, Seron K, Vasseur F, Aitman T and Froguel P (2004).
Genetic study of the CD36 gene In a French diabetic population. Diabetes Metab vol. 30, (5) 459-463.
10.1016/s1262-3636(07)70143-x
Higgins CF and
Linton KJ (2004).
The ATP switch model for ABC transporters. Nat Struct Mol Biol vol. 11, (10) 918-926.
10.1038/nsmb836
Rothnie A, Storm J, Campbell J,
Linton KJ, Kerr ID and Callaghan R (2004).
The topography of transmembrane segment six is altered during the catalytic cycle of P-glycoprotein. J Biol Chem vol. 279, (33) 34913-34921.
10.1074/jbc.M405336200
Lepretre F, Vasseur F, Vaxillaire M, Scherer PE, Ali S,
Linton KJ, Aitman T and Froguel P (2004).
A CD36 nonsense mutation associated with insulin resistance and familial type 2 diabetes. Hum Mutat vol. 24, 104-110.
10.1002/humu.92562003

Kerr ID, Berridge G,
Linton KJ, Higgins CF and Callaghan R (2003).
Definition of the domain boundaries is critical to the expression of the nucleotide-binding domains of P-glycoprotein. Eur Biophys J Biophy vol. 32, (7) 644-654.
10.1007/s00249-003-0327-6
Jodoin J, Demeule M, Fenart L, Cecchelli R, Farmer S,
Linton KJ, Higgins CF and Beliveau R (2003).
P-glycoprotein in blood-brain barrier endothelial cells: interaction and oligomerization with caveolins. J Neurochem vol. 87, (4) 1010-1023.
10.1046/j.1471-4159.2003.02081.x
Stenham DR, Campbell JD, Sansom MSP, Higgins CF, Kerr ID and
Linton KJ (2003).
An atomic detail model for the human ATP binding cassette transporter P-glycoprotein derived from disulphide cross-linking and homology modeling. Faseb J vol. 17, (13) 2287-+.
10.1096/fj.03-0107fje
Gabriel MP, Storm J, Rothnie A, Taylor AM,
Linton KJ, Kerr ID and Callaghan R (2003).
Communication between the nucleotide binding domains of P-glycoprotein occurs via conformational changes that involve residue 508. Biochemistry-Us vol. 42, (25) 7780-7789.
10.1021/bi0341049
Mullenbach R,
Linton KJ, Wiltshire S, Weerasekera N, Chambers J, Elias E, Higgins CF, Johnston DG, McCarthy MI and Williamson C (2003).
ABCB4 gene sequence variation in women with intrahepatic cholestasis of pregnancy. J Med Genet vol. 40, (5)
10.1136/jmg.40.5.e70
Byrne JA, Strautniks SS, Higgins CF,
Linton KJ and Thompson RJ (2003).
Function of BSEP., Editors: Paumgartner G.
Springer 2002

Byrne JA, Strautnieks SS, Mieli-Vergani G, Higgins CF,
Linton KJ and Thompson RJ (2002).
The human bile salt export pump: Characterization of substrate specificity and identification of inhibitors. Gastroenterology vol. 123, (5) 1649-1658.
10.1053/gast.2002.36591
Linton KJ and Higgins CF (2002).
P-glycoprotein misfolds in Escherichia coli: evidence against alternating-topology models of the transport cycle. Mol Membr Biol vol. 19, (1) 51-58.
10.1080/09687680110103622
Linton KJ, Rosenberg M, Kerr ID and Higgins CF (2002).
Structure of ABC transporters. Abc Proteins , Editors: Holland IB, Cole SPC, Kuchler K and Higgins CF.
Academic Press 10.1042/BSE0500043
Higgins CF and
Linton KJ (2002).
ABC transporters: An introduction and overview. Abc Proteins , Editors: Holland IB, Cole SPC, Kuchler K and Higgins CF.
Academic Press 2001

Taylor AM, Storm J, Soceneantu L,
Linton KJ, Gabriel M, Martin C, Woodhouse J, Blott E, Higgins CF and Callaghan R (2001).
Detailed characterization of cysteine-less P-glycoprotein reveals subtle pharmacological differences in function from wild-type protein. Brit J Pharmacol vol. 134, (8) 1609-1618.
10.1038/sj.bjp.0704400
Rosenberg MF, Velarde G, Ford RC, Martin C, Berridge G, Kerr ID, Callaghan R, Schmidlin A, Wooding C,
Linton KJ and Higgins CF (2001).
Repacking of the transmembrane domains of P-glycoprotein during the transport ATPase cycle. Embo J vol. 20, (20) 5615-5625.
10.1093/emboj/20.20.56152000

Dixon PH, Weerasekera N,
Linton KJ, Donaldson O, Chambers J, Egginton E, Weaver J, Nelson-Piercy C, de Swiet M, Warnes G, Elias E, Higgins CF, Johnston DG, McCarthy MI and Williamson C (2000).
Heterozygous MDR3 missense mutation associated with intrahepatic cholestasis of pregnancy: evidence for a defect in protein trafficking. Hum Mol Genet vol. 9, (8) 1209-1217.
10.1093/hmg/9.8.12091999

Blott EJ, Higgins CF and
Linton KJ (1999).
Cysteine-scanning mutagenesis provides no evidence for the extracellular accessibility of the nucleotide-binding domains of the multidrug resistance transporter P-glycoprotein. Embo J vol. 18, (23) 6800-6808.
10.1093/emboj/18.23.6800
Higgins CF, Weylandt KH, Nastrucci C, Sardini A,
Linton K, Diaz M and Valverde MA (1999).
Cell swelling-activated chloride channels and their regulation by P-glycoprotein. Chloride Channels , Editors: Kozlowski R.
Isis Press 1998
1997

Higgins CF, Callaghan R,
Linton KJ, Rosenberg MF and Ford RC (1997).
Structure of the multidrug resistance P-glycoprotein. Semin Cancer Biol vol. 8, (3) 135-142.
10.1006/scbi.1997.00671995
LINTON KJ, JARVIS BW and HUTCHINSON CR (1995).
CLONING OF THE GENES ENCODING THYMIDINE DIPHOSPHOGLUCOSE 4,6-DEHYDRATASE AND THYMIDINE DIPHOSPHO-4-KETO-6-DEOXYGLUCOSE 3,5-EPIMERASE FROM THE ERYTHROMYCIN-PRODUCING SACCHAROPOLYSPORA-ERYTHRAEA. Gene vol. 153, (1) 33-40.
10.1016/0378-1119(94)00809-71994
LINTON KJ, COOPER HN, HUNTER IS and LEADLAY PF (1994).
AN ABC-TRANSPORTER FROM STREPTOMYCES-LONGISPOROFLAVUS CONFERS RESISTANCE TO THE POLYETHER-IONOPHORE ANTIBIOTIC TETRONASIN. Mol Microbiol vol. 11, (4) 777-785.
10.1111/j.1365-2958.1994.tb00355.x1988
LINTON KJ and HUNTER IS (1988).
CLONING OF DNA-SEQUENCES FROM STREPTOMYCES-LONGISPOROFLAVUS WHICH CONFER INCREASED RESISTANCE TO THE IONOPHORE ANTIBIOTIC TETRONASIN IN STREPTOMYCES-LIVIDANS. Heredity vol. 61, 304-305.