Dr Ivan Kadurin
Lecturer in Physiology
School of Biological and Behavioural Sciences / Blizard Institute
QMUL
QMUL
Research
ion channels, neuronal signalling, electrophysiology, cellular trafficking, pharmacology, protein - protein interactions
Publications
2022
ADAM17 Mediates Proteolytic Maturation of Voltage-Gated Calcium Channel Auxiliary α2δ Subunits, and Enables Calcium Current EnhancementKadurin I, Dahimene S, Page KM, Ellaway JIJ, Chaggar K, Troeberg L
Function, Oxford University Press (Oup) vol. 3 (3)
17-03-2022
Biallelic CACNA2D1 loss-of-function variants cause early-onset developmental epileptic encephalopathyDahimene S, von Elsner L, Holling T, Mattas LS, Pickard J, Lessel D, Pilch KS, Kadurin I et al.
Brain, Oxford University Press (Oup) vol. 145 (8), 2721-2729.
16-03-2022
2020
Fight or flight: The culprit is lurking in the neighbourhoodDolphin AC
Cell Calcium, Elsevier vol. 87
11-02-2020
2019
Disruption of the Key Ca2+ Binding Site in the Selectivity Filter of Neuronal Voltage-Gated Calcium Channels Inhibits Channel TraffickingMeyer JO, Dahimene S, Page KM, Ferron L, Kadurin I, Ellaway JIJ, Zhao P, Lin P et al.
Cell Reports, Elsevier vol. 29 (1), 22-33.e5.
01-10-2019
2018
The α2δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α2δ-1Dahimene S, Page KM, Kadurin I, Ferron L, Ho DY, Powell GT
Cell Reports, Elsevier vol. 25 (6), 1610-1621.e5.
01-11-2018
Proteolytic maturation of α2δ controls the probability of synaptic vesicular releaseFerron L, Kadurin I, Dolphin AC
Elife, Elife vol. 7
19-06-2018
2017
LRP1 influences trafficking of N-type calcium channels via interaction with the auxiliary α2δ-1 subunitKadurin I, Rothwell SW, Lana B
Scientific Reports, Springer Nature vol. 7 (1)
03-03-2017
2016
Proteolytic maturation of α2δ represents a checkpoint for activation and neuronal trafficking of latent calcium channelsKadurin I, Ferron L, Rothwell SW, Meyer JO, Douglas LR, Bauer CS, Lana B, Alexopoulos O et al.
Elife, Elife vol. 5
26-10-2016
Thrombospondin-4 reduces binding affinity of [3H]-gabapentin to calcium-channel α2δ-1-subunit but does not interact with α2δ-1 on the cell-surface when co-expressedLana B, Page KM, Kadurin I, Nieto-Rostro M, Dolphin AC
Scientific Reports, Springer Nature vol. 6 (1)
14-04-2016
2014
Functional exofacially tagged N-type calcium channels elucidate the interaction with auxiliary α2δ-1 subunitsCassidy JS, Ferron L, Pratt WS
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 111 (24), 8979-8984.
02-06-2014
The inhibition of functional expression of calcium channels by prion protein demonstrates competition with α2δ for GPI-anchoring pathwaysAlvarez-Laviada A, Kadurin I, Chiesa R
Biochemical Journal, Portland Press vol. 458 (2), 365-374.
14-02-2014
2012
Calcium Currents Are Enhanced by α2δ-1 Lacking Its Membrane Anchor*Kadurin I, Alvarez-Laviada A, Walker-Gray R, Fadel MG, Pratt WS
Journal of Biological Chemistry, Elsevier vol. 287 (40), 33554-33566.
06-08-2012
Voltage-Gated Calcium Channel α2δ Subunits in Lipid Rafts: The Importance of Proteolytic Cleavage Into α2 and δKadurin I, Bauer C, Alvarez-Laviada A, Nieto-Rostro M, Douglas L
01-01-2012
2011
Presynaptic HCN1 channels regulate CaV3.2 activity and neurotransmission at select cortical synapsesHuang Z, Lujan R, Kadurin I, Shah MM
Nature Neuroscience, Springer Nature vol. 14 (4), 478-486.
27-02-2011
2010
A new look at calcium channel α2δ subunitsBauer CS, Tran-Van-Minh A, Kadurin I
Current Opinion in Neurobiology, Elsevier vol. 20 (5), 563-571.
25-06-2010
The α2δ subunits of voltage-gated calcium channels form GPI-anchored proteins, a posttranslational modification essential for functionDavies A, Kadurin I, Alvarez-Laviada A, Douglas L, Nieto-Rostro M
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 107 (4), 1654-1659.
04-01-2010
2009
The Increased Trafficking of the Calcium Channel Subunit α2δ-1 to Presynaptic Terminals in Neuropathic Pain Is Inhibited by the α2δ Ligand PregabalinBauer CS, Nieto-Rostro M, Rahman W, Tran-Van-Minh A, Ferron L, Douglas L, Kadurin I, Ranjan YS et al.
Journal of Neuroscience, Society For Neuroscience vol. 29 (13), 4076-4088.
01-04-2009
A single conserved proline residue determines the membrane topology of stomatinKadurin I, Huber S
Biochemical Journal, Portland Press vol. 418 (3), 587-594.
25-02-2009
2008
Differential effects of N-glycans on surface expression suggest structural differences between the acid-sensing ion channel (ASIC) 1a and ASIC1bKadurin I, Golubovic A, Leisle L
Biochemical Journal, Portland Press vol. 412 (3), 469-475.
28-05-2008
2007
Zebrafish Acid-sensing Ion Channel (ASIC) 4, Characterization of Homo- and Heteromeric Channels, and Identification of Regions Important for Activation by H+ *Chen X, Polleichtner G, Kadurin I
Journal of Biological Chemistry, Elsevier vol. 282 (42), 30406-30413.
07-08-2007
2006
Strong modulation by RFamide neuropeptides of the ASIC1b/3 heteromer in competition with extracellular calciumChen X, Paukert M, Kadurin I, Pusch M
Neuropharmacology, Elsevier vol. 50 (8), 964-974.
20-03-2006
Grants
Amyloids and Oligomers. Curvilinear and annular structures and their interation with exosomes and whole cellsJohn Viles, Ivan Kadurin, Vladimir Volkov and Vidya Darbari
£485,209 Biotechnology and Biological Sciences Research Council
01-12-2023 - 29-11-2027
Proteolytic activation of calcium channels: potential target for channel - directed therapeutics in arterial smooth muscle cells - Grant Transfer Dr I KadurinIvan Kadurin
£488,751 MRC Medical Research Council
01-11-2022 - 30-09-2026
Highthroughput Light Sheet Microscopy: Imaging Across ScalesViji Draviam Sastry, Caroline Brennan, Vidya Darbari, Jose Martin Duran, Ivan Kadurin, Isabel M Palacios, Richard Pickersgill, Sarah McClelland, Tyson Sharp and Martin Knight
£386,205 MRC Medical Research Council
01-10-2022 - 31-03-2023