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Dr Gunnel Halldén

Gunnel Halldén

Barts Cancer Institute
020 8888 3593

Research

oncolytic virus, prostate cancer, pancreatic cancer

Interests

virology, adenovirus, cell killing modes, novel therapeutics

Publications of specific relevance to Predictive in vitro Models

Publications

2019

Stella Man YK, Foster J, Carapuça E, Davies JA, Parker AL, Sosabowski J and Halldén G (2019). Systemic delivery and SPECT/CT in vivo imaging of 125I-labelled oncolytic adenoviral mutants in models of pancreatic cancer. Scientific Reports  vol. 9, (1) 10.1038/s41598-019-49150-9
Hallden G, Wang Y, Wong H-H and Lemoine NR (2019). ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY. Advanced Textbook On Gene Transfer, Gene Therapy and Genetic Pharmacology  10.1142/9781786346889_0019

2018

Nattress CB and Halldén G (2018). Advances in oncolytic adenovirus therapy for pancreatic cancer. Cancer Lett  vol. 434, 56-69. 10.1016/j.canlet.2018.07.006
Baker AT, Aguirre-Hernández C, Halldén G and Parker AL (2018). Designer Oncolytic Adenovirus: Coming of Age. Cancers (Basel)  vol. 10, (6) 10.3390/cancers10060201
Man YKS, Davies JA, Coughlan L, Pantelidou C, Blázquez-Moreno A, Marshall JF, Parker AL and Halldén G (2018). The novel oncolytic adenoviral mutant Ad5-3Δ-A20T retargeted to αvβ6 integrins efficiently eliminates pancreatic cancer cells. Molecular Cancer Therapeutics  vol. 17, (2) 575-587. 10.1158/1535-7163.MCT-17-0671
Aguirre-Hernández C, Maya-Pineda H, Millán JS, Man YKS, Lu YJ and Halldén G (2018). Sensitisation to mitoxantrone-induced apoptosis by the oncolytic adenovirus AdΔΔ through Bcl-2-dependent attenuation of autophagy. Oncogenesis  vol. 7, (1) 10.1038/s41389-017-0020-8

2017

Hallden G (2017). Targeting pancreatic and prostate cancer with E1B19K-deleted oncolytic adenoviruses. Human Gene Therapy  vol. 28, (8) A6-A6.

2016

Aguirre-Hernandez C, Millan JS and Hallden G (2016). The adenoviral Ad Delta Delta mutant enhances mitoxantrone-induced apoptosis and attenuates drug-induced autophagy in prostate cancer cells.
Pantelidou C, Cherubini G, Lemoine NR and Halldén G (2016). The E1B19K-deleted oncolytic adenovirus mutant AdΔ19K sensitizes pancreatic cancer cells to drug-induced DNA-damage by down-regulating Claspin and Mre11. Oncotarget  vol. 7, (13) 15703-15724. 10.18632/oncotarget.7310
Sweeney K and Halldén G (2016). Oncolytic adenovirus-mediated therapy for prostate cancer. Oncolytic Virother  vol. 5, 45-57. 10.2147/OV.S63047
Pantelidou C, Man YKS, Coughlan L, Marshall J, Kocher H and Hallden G (2016). Oncolytic adenoviral mutants deleted in the anti-apoptotic E1B19K gene sensitize pancreatic cancer cells to drug-induced DNA damage. International Journal of Molecular Medicine  vol. 38, S58-S58.

2014

Hallden G, Wang Y, Wong H-H and Lemoine NR (2014). 18: ONCOLYTIC ADENOVIRUSES FOR CANCER GENE THERAPY. Advanced Textbook On Gene Transfer, Gene Therapy and Genetic Pharmacology  10.1142/9781848168305_0018

2013

Passaro C, Abagnale A, Libertini S, Volpe M, Botta G, Cella L, Pacelli R, Halldèn G, Gillespie D and Portella G (2013). Ionizing radiation enhances dl922-947-mediated cell death of anaplastic thyroid carcinoma cells. Endocr Relat Cancer  vol. 20, (5) 633-647. 10.1530/ERC-13-0001

2012

Halldén G and Portella G (2012). Oncolytic virotherapy with modified adenoviruses and novel therapeutic targets. Expert Opin Ther Targets  vol. 16, (10) 945-958. 10.1517/14728222.2012.712962
Adam V, Ekblad M, Sweeney K, Müller H, Busch KH, Johnsen CT, Kang NR, Lemoine NR and Halldén G (2012). Synergistic and Selective Cancer Cell Killing Mediated by the Oncolytic Adenoviral Mutant AdΔΔ and Dietary Phytochemicals in Prostate Cancer Models. Hum Gene Ther  vol. 23, (9) 1003-1015. 10.1089/hum.2012.046
Botta G, Passaro C, Libertini S, Abagnale A, Barbato S, Maione AS, Hallden G, Beguinot F, Formisano P and Portella G (2012). Inhibition of autophagy enhances the effects of E1A-defective oncolytic adenovirus dl922-947 against glioma cells in vitro and in vivo. Hum Gene Ther  vol. 23, (6) 623-634. 10.1089/hum.2011.120
Sweeney KG, Cheong SC, Lemoine NR and Hallden G (2012). Abstract 2712: A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells. 10.1158/1538-7445.am2012-2712
Maya-Pineda HR, Miranda-Rota E, Lemoine NR and Halldén G (2012). Abstract 2713: Adenovirus E1A binding to p300 is essential for synergistic cell killing in combination with chemotherapeutic drugs in prostate cancer cells. 10.1158/1538-7445.am2012-2713
Halldén G (2012). Adenoviral gene expression and replication in human tumor explant models. Methods Mol Biol  vol. 797, 65-78. 10.1007/978-1-61779-340-0_5
Miranda E, Maya Pineda H, Öberg D, Cherubini G, Garate Z, Lemoine NR and Halldén G (2012). Adenovirus-mediated sensitization to the cytotoxic drugs docetaxel and mitoxantrone is dependent on regulatory domains in the E1ACR1 gene-region. Plos One  vol. 7, (10) 10.1371/journal.pone.0046617

2011

Cherubini G, Kallin C, Mozetic A, Hammaren-Busch K, Müller H, Lemoine NR and Halldén G (2011). The oncolytic adenovirus AdΔΔ enhances selective cancer cell killing in combination with DNA-damaging drugs in pancreatic cancer models. Gene Ther  vol. 18, (12) 1157-1165. 10.1038/gt.2011.141
Bhattacharyya M, Francis J, Eddouadi A, Lemoine NR and Halldén G (2011). An oncolytic adenovirus defective in pRb-binding (dl922-947) can efficiently eliminate pancreatic cancer cells and tumors in vivo in combination with 5-FU or gemcitabine. Cancer Gene Ther  vol. 18, (10) 734-743. 10.1038/cgt.2011.45
Pantelidou C, Cherubini G, Lemoine NR and Hallden G (2011). Adenovirus sensitizes pancreatic cancer cells to DNA-damaging chemotherapeutics through mitotic catastrophe induction and this is further enhanced by the deletion of the anti-apoptotic E1B19K gene. Human Gene Therapy  vol. 22, (10) A119-A120.
Sweeney K, Cheong SC, Lemoine N and Hallden G (2011). A non-replicating adenovirus expressing Hey1 is cytotoxic to prostate cancer cells. Human Gene Therapy  vol. 22, (10) A122-A122.
Maya-Pineda H, Miranda E, Lemoine N and Hallden G (2011). Adenovirus CIA binding to p300 is essential for synergistic cell killing in combination with chemotherapeutics in prostate cancer cells. Human Gene Therapy  vol. 22, (10) A104-A104.

2010

Ingemarsdotter CK, Baird SK, Connell CM, Öberg D, Halldén G and McNeish IA (2010). Low-dose paclitaxel synergizes with oncolytic adenoviruses via mitotic slippage and apoptosis in ovarian cancer. Oncogene  vol. 29, (45) 6051-6063. 10.1038/onc.2010.335
Radhakrishnan S, Miranda E, Ekblad M, Holford A, Pizarro MT, Lemoine NR and Halldén G (2010). Efficacy of oncolytic mutants targeting pRb and p53 pathways is synergistically enhanced when combined with cytotoxic drugs in prostate cancer cells and tumor xenografts. Hum Gene Ther  vol. 21, (10) 1311-1325. 10.1089/hum.2010.019
Ekblad M and Halldén G (2010). Adenovirus-based therapy for prostate cancer. Curr Opin Mol Ther  vol. 12, (4) 421-431.
Oberg D, Yanover E, Adam V, Sweeney K, Costas C, Lemoine NR and Halldén G (2010). Improved potency and selectivity of an oncolytic E1ACR2 and E1B19K deleted adenoviral mutant in prostate and pancreatic cancers. Clin Cancer Res  vol. 16, (2) 541-553. 10.1158/1078-0432.CCR-09-1960

2009

Lee M, Choi S, Halldén G, Yo SJ, Schichnes D and Aponte GW (2009). P2Y5 is a G(alpha)i, G(alpha)12/13 G protein-coupled receptor activated by lysophosphatidic acid that reduces intestinal cell adhesion. Am J Physiol Gastrointest Liver Physiol  vol. 297, (4) G641-G654. 10.1152/ajpgi.00191.2009
Hallden G (2009). Optimisation of replication-selective oncolytic adenoviral mutants in combination with chemotherapeutics. J Buon  vol. 14, S61-S67.
Leitner S, Sweeney K, Oberg D, Davies D, Miranda E, Lemoine NR and Halldén G (2009). Oncolytic adenoviral mutants with E1B19K gene deletions enhance gemcitabine-induced apoptosis in pancreatic carcinoma cells and anti-tumor efficacy in vivo. Clin Cancer Res  vol. 15, (5) 1730-1740. 10.1158/1078-0432.CCR-08-2008

2008

Libertini S, Iacuzzo I, Perruolo G, Scala S, Ierano C, Franco R, Hallden G and Portella G (2008). Bevacizumab Increases Viral Distribution in Human Anaplastic Thyroid Carcinoma Xenografts and Enhances the Effects of E1A-Defective Adenovirus d/922-947. Clin Cancer Res  vol. 14, (20) 6505-6514. 10.1158/1078-0432.CCR-08-0200
Bazan-Peregrino M, Carlisle RC, Hernandez-Alcoceba R, Iggo R, Homicsko K, Fisher KD, Halldén G, Mautner V, Shen Y and Seymour LW (2008). Comparison of molecular strategies for breast cancer virotherapy using oncolytic adenovirus. Hum Gene Ther  vol. 19, (9) 873-886. 10.1089/hum.2008.047
Seymour LW, Bazan-Peregrino M, Carlisle R, Hernandez-Alcoceba R, Iggo R, Homicsko K, Hallden G, Mautner V, Shen J and Fisher K (2008). Comparison of Molecular Strategies for Breast Cancer Virotherapy using Oncolytic Adenovirus. Hum Gene Ther  10.1089/hgt.2008.047
Cheong SC, Wang Y, Meng J-H, Hill R, Sweeney K, Kirn D, Lemoine NR and Halldén G (2008). E1A-expressing adenoviral E3B mutants act synergistically with chemotherapeutics in immunocompetent tumor models. Cancer Gene Ther  vol. 15, (1) 40-50. 10.1038/sj.cgt.7701099

2007

Gaballah K, Hills A, Curiel D, Hallden G, Harrison P and Partridge M (2007). Lysis of dysplastic but not normal oral keratinocytes and tissue-engineered epithelia with conditionally replicating adenoviruses. Cancer Res  vol. 67, (15) 7284-7294. 10.1158/0008-5472.CAN-06-3834
Choi S, Lee M, Shiu AL, Yo SJ, Hallden G and Aponte GW (2007). GPR93 activation by protein hydrolysate induces CCK transcription and secretion in STC-1 cells. Am J Physiol-Gastr L  vol. 292, (5) G1366-G1375. 10.1152/ajpgi.00516.2006

2006

Bapat U, Wang Y, Alusi G, Chisholm E, Francis J, Hallden G and Lemoine N (2006). Oncolytic virotherapy for nasopharyngeal cancer. Clinical Otolaryngology  vol. 31, (6) 582-583. 10.1111/j.1365-2273.2006.01341_13.x

2005

Liu T-C, Wang Y, Hallden G, Brooks G, Francis J, Lemoine NR and Kirn D (2005). Functional interactions of antiapoptotic proteins and tumor necrosis factor in the context of a replication-competent adenovirus. Gene Ther  vol. 12, (17) 1333-1346. 10.1038/sj.gt.3302555
Wang Y, Xue S-A, Hallden G, Francis J, Yuan M, Griffin BE and Lemoine NR (2005). Virus-associated RNA I-deleted adenovirus, a potential oncolytic agent targeting EBV-associated tumors. Cancer Res  vol. 65, (4) 1523-1531. 10.1158/0008-5472.CAN-04-3113
Lee M, Hadi M, Halldén G and Aponte GW (2005). Peptide YY and neuropeptide Y induce villin expression, reduce adhesion, and enhance migration in small intestinal cells through the regulation of CD63, matrix metalloproteinase-3, and Cdc42 activity. J Biol Chem  vol. 280, (1) 125-136. 10.1074/jbc.M408858200
Wang Y, Thorne S, Hannock J, Francis J, Au T, Reid T, Lemoine N, Kirn D and Halldén G (2005). A novel assay to assess primary human cancer infectibility by replication-selective oncolytic adenoviruses. Clin Cancer Res  vol. 11, (1) 351-360. 10.1158/1078-0432.ccr-04-2548

2004

Wang Y, Faux SP, Hallden G, Kirn DH, Houghton CE, Lemoine NR and Patrick G (2004). Interleukin-1beta and tumour necrosis factor-alpha promote the transformation of human immortalised mesothelial cells by erionite. Int J Oncol  vol. 25, (1) 173-178. 10.3892/ijo.25.1.173
Liu T-C, Hallden G, Wang Y, Brooks G, Francis J, Lemoine N and Kirn D (2004). An E1B-19 kDa gene deletion mutant adenovirus demonstrates tumor necrosis factor-enhanced cancer selectivity and enhanced oncolytic potency. Mol Ther  vol. 9, (6) 786-803. 10.1016/j.ymthe.2004.03.017
Halldén G, Thorne SH, Yang J and Kirn DH (2004). Replication-selective oncolytic adenoviruses. Methods Mol Med  vol. 90, 71-90. 10.1385/1-59259-429-8:71

2003

Wang Y, Hallden G, Hill R, Anand A, Liu T-C, Francis J, Brooks G, Lemoine N and Kirn D (2003). E3 gene manipulations affect oncolytic adenovirus activity in immunocompetent tumor models. Nat Biotechnol  vol. 21, (11) 1328-1335. 10.1038/nbt887
Halldén G, Hill R, Wang Y, Anand A, Liu T-C, Lemoine NR, Francis J, Hawkins L and Kirn D (2003). Novel immunocompetent murine tumor models for the assessment of replication-competent oncolytic adenovirus efficacy. Mol Ther  vol. 8, (3) 412-424. 10.1016/s1525-0016(03)00199-0

2002

Kirn D, Niculescu-Duvaz I, Hallden G and Springer CJ (2002). The emerging fields of suicide gene therapy and virotherapy. Trends Mol Med  vol. 8, (4 Suppl) S68-S73. 10.1016/s1471-4914(02)02318-3