Professor Francesco Dell'Accio

Francesco Dell'Accio

Professor for Musculoskeletal Medicine and Rheumatology

Queen Mary, University of London
07557 028104

Research

Osteoarthritis, Cartilage regeneration, Pain

Musculoskeletal Models

Interests

Expert in in models of chondrogenesis, pain and osteoarthritis

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

ABS0240 MECHANO-ACTIVATED CHONDROPROGENITORS (MACS) DERIVED FROM ARTICULAR CHONDROCYTES, WHICH DRIVE INTRINSIC CARTILAGE REPAIR
Zhu L, Muhammad H, Perry TA, Ardasheva A, Symons RA, Mcclure JJ, Kania K, Clark SM et al.
Annals of The Rheumatic Diseases, Elsevier vol. 84, 1737-1738.  
01-06-2025

2024

TRPC1 links calcium signaling to cellular senescence in the protection against post-traumatic osteoarthritis
Sambale M, Lively S, Espin-Garcia O, Potla P, Pastrello C, Bödecker S, Wessendorf L, Kleimann S et al.
Jci Insight, American Society For Clinical Investigation vol. 10 (3) 
24-12-2024
Molecular Determinants of Neutrophil Extracellular Vesicles That Drive Cartilage Regeneration in Inflammatory Arthritis
Thomas BL, Montero‐Melendez T, Oggero S, Kaneva MK, Chambers D, Pinto AL, Nerviani A, Lucchesi D et al.
Arthritis & Rheumatology, Wiley vol. 76 (12), 1705-1718.  
16-08-2024
Regenerative Medicine and Tissue Engineering
Dell'Accio F, De Bari C, Firestein GS, McInnes I
In Firestein & Kelley's Textbook of Rheumatology - 12th Edition, Elsevier Health Sciences 
24-07-2024
645 FUNCTIONAL INTERACTION OF CXCR2 AND β1-INTEGRIN SIGNALING IN THE REGULATION OF CARTILAGE HOMEOSTASIS
Asgarian R, Schäfer A, Gronewold R, Dell'Accio F, Pap T, Sherwood J
Osteoarthritis and Cartilage, Elsevier vol. 32 
01-04-2024
069 INTRA-ARTICULAR ADMINISTRATION OF AGRIN INDUCES RAPID AND SUSTAINED PAIN RELIEF IN OSTEOARTHRITIS
Dajas-Bailador F, Chapman V, Lucci C, Rathbone A, Bharde S, Sikandar S, Dell'Accio F, Eldridge S
Osteoarthritis and Cartilage, Elsevier vol. 32 
01-04-2024

2023

Sortilin Is Upregulated in Osteoarthritis-Dependent Cartilage Calcification and Associated with Cellular Senescence
Richter E, Lohmann CH, Dell’Accio F, Goettsch C, Bertrand J
International Journal of Molecular Sciences, Mdpi vol. 24 (15) 
02-08-2023
AB0036 HIGH THROUGHPUT siRNA EFFICACY SCREENING USING FLUORESCENCE SYSTEM
Deniz M, Pour LH, Thorup AS, Dell'accio F
Annals of The Rheumatic Diseases, Elsevier vol. 82 
01-06-2023
Towards disease modification in osteoarthritis
Dell'Accio F, De Bari C
Osteoarthritis and Cartilage, Elsevier vol. 31 (9), 1154-1155.  
16-05-2023
Neutrophils infiltrate sensory ganglia and mediate chronic widespread pain in fibromyalgia
Caxaria S, Bharde S, Fuller AM, Evans R, Thomas B, Celik P, Dell’Accio F, Yona S et al.
Proceedings of The National Academy of Sciences of The United States of America, Proceedings of The National Academy of Sciences vol. 120 (17), e2211631120-e2211631120.  
18-04-2023

2022

Disease modification and symptom relief in osteoarthritis using a mutated GCP‐2/CXCL6 chemokine
Caxaria S, Kouvatsos N, Eldridge SE, Alvarez‐Fallas M, Thorup A, Cici D, Barawi A, Arshed A et al.
Embo Molecular Medicine, Springer Nature vol. 15 (1) 
12-12-2022
A Mouse Model of Acute Cartilage Injury and Repair
Thorup A-S, Dell’Accio F, Eldridge SE
Methods in Molecular Biology, Springer Nature vol. 2598, 337-344.  
11-11-2022
AB0156 INTRA-ARTICULAR AGRIN PROVIDES DIRECT PAIN RELIEF IN OSTEOARTHRITIS AND CARTILAGE DEFECTS
Eldridge S, Barawi A, Thorup AS, Fernandez BF, Bharde S, Sikandar S, Guan Z, Kaneva M et al.
Annals of The Rheumatic Diseases, Elsevier vol. 81 
01-06-2022
POS0229 ELUCIDATING THE MECHANISM OF ACTION DOWNSTREAM OF ROR2 BLOCKADE: A PHOSPHOPROTEOMIC APPROACH
Thorup AS, Wilson J, Cutillas P, Dell'accio F
 
01-06-2022
SCREENING SIRNA EFFICACY USING HIGH THROUGHPUT FLUORESCENCE SYSTEM IN VITRO.
Deniz M, Thorup A-S, Dell'Accio F
Osteoarthritis and Cartilage, Elsevier vol. 30, s433-s434.  
01-04-2022
BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS, IN PART BY MODULATING YAP SIGNALLING
Thorup A-S, Wilson J, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G et al.
Osteoarthritis and Cartilage, Elsevier vol. 30 
01-04-2022
INHIBITION OF LOX MEDIATED EXTRACELLULAR MATRIX STIFFENING PREVENTS WNT3A INDUCED CHONDROCYTE DIFFERENTIATION VIA THE YAP/ TAZ PATHWAY
Held A, Bollmann M, Hansen U, Pap T, Dell'Accio F, Aszodi A, Prein C, Clausen-Schaumann H et al.
Osteoarthritis and Cartilage, Elsevier vol. 30 
01-04-2022
In vivo potency assay for the screening of bioactive molecules on cartilage formation
Thorup A-S, Caxaria S, Thomas BL, Suleman Y, Nalesso G, Luyten FP, Dell’Accio F, Eldridge SE
Lab Animal, Springer Nature vol. 51 (4), 103-120.  
31-03-2022
SCREENING SIRNA EFFICACY USING HIGH THROUGHPUT FLUORESCENCE SYSTEM IN VITRO
Deniz M, Thorup A-S, Dell'Accio F
 
01-01-2022
Screening siRNA efficacy using high throughput fluorescence system in vitro
Deniz M, Thorup AS, Dell'Accio F
 
01-01-2022

2021

OP0200 BLOCKING ROR2 IMPROVES CARTILAGE INTEGRITY AND PROVIDES PAIN RELIEF IN OSTEOARTHRITIS
Thorup AS, Strachan D, Caxaria S, Poulet B, Thomas B, Eldridge S, Nalesso G, Whiteford J et al.
Annals of The Rheumatic Diseases, Elsevier vol. 80, 120-121.  
01-06-2021
AB0039 AGRIN REPAIRS BONE AND CARTILAGE IN VIVO
Eldridge S, Barawi A, Wang H, Roelofs A, Kaneva M, Guan Z, Lydon H, Thomas B et al.
Annals of The Rheumatic Diseases vol. 80 (Suppl 1), 1052.1-101052.  
19-05-2021
WNT3A‐loaded exosomes enable cartilage repair
Thomas BL, Eldridge SE, Nosrati B, Alvarez M, Thorup A, Nalesso G, Caxaria S, Barawi A et al.
Journal of Extracellular Vesicles, Wiley vol. 10 (7) 
01-05-2021
Update on pain in arthritis
Bharde S, Caxaria S, Dell’Accio F, Sikandar S
Current Opinion in Supportive and Palliative Care, Wolters Kluwer vol. 15 (2), 99-107.  
08-04-2021
Alpha‐1‐antitrypsin reduces inflammation and exerts chondroprotection in arthritis
Kaneva MK, Muley MM, Krustev E, Reid AR, Souza PR, Dell’Accio F, McDougall JJ, Perretti M
The Faseb Journal, Wiley vol. 35 (5) 
31-03-2021
Calcium calmodulin kinase II activity is required for cartilage homeostasis in osteoarthritis
Nalesso G, Thorup A-S, Eldridge SE, De Palma A, Kaur A, Peddireddi K, Blighe K, Rana S et al.
Scientific Reports, Springer Nature vol. 11 (1) 
11-03-2021
TNF alpha-stimulated gene 6 (TSG-6) is weakly chondroprotective in murine OA but does not account for FGF2-mediated joint protection
Zhu L, Donhou S, Burleigh A, Zarebska JM, Curtinha M, Parisi I, Khan SN, Dell'Accio F et al.
 
01-01-2021
In a surgical model of OA female mice compared to males display pain at an early stage of disease and differential regulation of pain sensitizers
Chia S-L, Stott B, Miotla-Zarebska J, Riley D, Dell'Accio F, Vincent TL
 
01-01-2021

2020

Does Pain at an Earlier Stage of Chondropathy Protect Female Mice Against Structural Progression After Surgically Induced Osteoarthritis?
von Loga IS, Batchelor V, Driscoll C, Burleigh A, Chia SL, Stott B, Miotla‐Zarebska J, Riley D et al.
Arthritis & Rheumatology, Wiley vol. 72 (12), 2083-2093.  
04-11-2020
TSG‐6 Is Weakly Chondroprotective in Murine OA but Does not Account for FGF2‐Mediated Joint Protection
Zhu L, Donhou S, Burleigh A, Zarebska JM, Curtinha M, Parisi I, Khan SN, Dell’Accio F et al.
Acr Open Rheumatology, Wiley vol. 2 (10), 605-615.  
01-10-2020
ROR2 blockade as a therapy for osteoarthritis
Thorup A-S, Strachan D, Caxaria S, Poulet B, Thomas BL, Eldridge SE, Nalesso G, Whiteford JR et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 12 (561) 
16-09-2020
Agrin induces long-term osteochondral regeneration by supporting repair morphogenesis
Eldridge SE, Barawi A, Wang H, Roelofs AJ, Kaneva M, Guan Z, Lydon H, Thomas BL et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 12 (559) 
02-09-2020
Lessons from joint development for cartilage repair in the clinic
Thorup A, Dell'Accio F, Eldridge SE
Developmental Dynamics, Wiley vol. 250 (3), 360-376.  
25-08-2020
BCP crystals promote chondrocyte hypertrophic differentiation in OA cartilage by sequestering Wnt3a
Bertrand J, Kräft T, Gronau T, Sherwood J, Rutsch F, Lioté F, Dell'Accio F, Lohmann CH et al.
Annals of The Rheumatic Diseases, Elsevier vol. 79 (7), 975-984.  
05-05-2020
Short term il1ra treatment reduces post-traumatic OA in mouse in vivo and, in vitro, in human cartilage
Bollmann M, Brinkema H, Piatek S, Walcher F, Alvarez M, Eldridge S, Dell'Accio F, Bertrand J
 
01-04-2020
Expression of growth and differentiation factor 5 during joint repair and osteoarthritis
Kania K, Colella F, Riemen AH, Wang H, Howard KA, Aigner T, Dell'Accio F, Capellini TD et al.
 
01-04-2020
Regulation of Gdf5 expression in joint remodelling, repair and osteoarthritis
Kania K, Colella F, Riemen AHK, Wang H, Howard KA, Aigner T, Dell’Accio F, Capellini TD et al.
Scientific Reports, Springer Nature vol. 10 (1) 
13-01-2020
IDENTIFICATION OF PUTATIVE SEX-DEPENDENT PAIN PATHWAYS THAT MAY EXPLAIN WHY FEMALE MICE DEVLOP PAIN BEHAVIOUR DESPITE LOWER CHONDROPATHY SCORES
Batchelor V, von Loga IS, Driscoll C, Stott B, Miotla-Zarebska J, Dell'Accio F, Vincent TL
 
01-01-2020
LIVER X RECEPTOR ACTIVATION PROTECTS FROM SURGICALLY-INDUCED KNEE OSTEOARTHRITIS IN MICE
Behler-Janbeck F, Schmidt T, Eldridge S, Heeren J, Dell'accio F, Niemeier A
 
01-01-2020

2019

Inhibition of SDC4-LOX mediated extracellular matrix stiffening prevents chondrocyte differentiation in OA cartilage via increased YAP/TAZ signaling
Held A, Bollmann M, Hansen U, Pap T, Dell'Accio F, Prein C, Aszodi A, Clausen-Schaumann H et al.
 
01-04-2019
FGF2 promotes regeneration of cartilage in vivo by promoting MSC chemokinesis
Muhammad H, Khan SN, Scammahorn JJ, Dell'Accio F, De Bari C, Colella F, Roelofs A, Vincent T
 
01-01-2019

2018

Fibroblast growth factor 2 promotes regeneration of cartilage by attracting mesenchymal stem cells to the site of cartilage injury
Khan SN, Muhammad H, Scammahorn JJ, Dell'Accio F, Vincent TL
 
01-04-2018
Neutrophil extracellular vesicles have a cartilage protective effect during inflammatory arthritis
Thomas BL, Jones HR, Norling LV, Headland SE, Pitzalis C, Dell'Accio F, Perretti M
 
01-04-2018
The role of GCP-2 in cartilage differentiation and repair
Fallas MA, Caxaria S, Sherwood J, Luyten F, Pitzalis C, Dell'Accio F
 
01-04-2018
Transient receptor potential cation channel (TRPC6) as a regulator of CXCR2-mediated articular cartilage homeostasis
Sherwood J, Sambale M, Bertrand J, Dell'Accio F, Pap T
 
01-04-2018
Neutrophil Microvesicles from Healthy Control and Rheumatoid Arthritis Patients Prevent the Inflammatory Activation of Macrophages
Rhys HI, Dell'Accio F, Pitzalis C, Moore A, Norling LV, Perretti M
Ebiomedicine, Elsevier vol. 29, 60-69.  
07-02-2018
CXCL6: a glycosaminoglycan-binding chemokine with pro-inflammatory activities that are modulated by heparin and TSG-6
Kouvatsos N, Dodd R, Mahmood F, Milner CM, Dell'Accio F, Day AJ
 
01-01-2018

2017

Pharmacological blockade of the WNT-beta-catenin signaling: a possible first-in-kind DMOAD
Dell'Accio F, Cailotto F
Osteoarthritis and Cartilage, Elsevier vol. 26 (1), 4-6.  
25-10-2017
Toward classification criteria for early osteoarthritis of the knee
Luyten FP, Bierma-Zeinstra S, Dell’Accio F, Kraus VB, Nakata K, Sekiya I, Arden NK, Lohmander LS
Seminars in Arthritis and Rheumatism, Elsevier vol. 47 (4), 457-463.  
09-08-2017
High fat diet accelerates cartilage repair in DBA/1 mice
Wei W, Bastiaansen‐Jenniskens YM, Suijkerbuijk M, Kops N, Bos PK, Verhaar JAN, Zuurmond A, Dell'Accio F et al.
Journal of Orthopaedic Research®, Wiley vol. 35 (6), 1258-1264.  
18-04-2017
Agrin inhibits canonical WNT signalling through LRP4
Eldridge SE, Thomas BL, Shanmuganathan K, Strachan D, Ali A, Thorup A-S, Caxaria S, Nalesso G et al.
 
01-04-2017
WNT16 is up-regulated in the joint following inflammation
Thomas BL, Nalesso G, Eldridge SE, Pitzalis C, Dell'accio F
 
01-04-2017
The Role of CXCl6 in Cartilage Development and Homeostasis
Caxaria S, Sherwood J, Roeder E, Luyten F, Pitzalis C, Dell'Accio F
 
01-04-2017
A Potency Assay for Assessing the Chondrogenic Efficiency of Bioactive Molecules in Human Cartilage in vivo
Thorup A-S, Eldridge SE, Caxaria S, Nalesso G, Thomas BL, Pitzalis C, Luyten F, Dell'Accio F
 
01-04-2017
In Vivo Models of Cartilage Repair and Chondrogenesis
Dell'Accio F
 
01-04-2017
The role of transient receptor potential cation channel trpc6 activity in cxcr2-mediated chondrocyte phenotypic stability
Sherwood J, Bertrand J, Dell'Accio F, Pap T
Osteoarthritis and Cartilage, Elsevier vol. 25 
01-04-2017
THE ROLE OF TRANSIENT RECEPTOR POTENTIAL CATION CHANNEL TRPC6 ACTIVITY IN CXCR2-MEDIATED CHONDROCYTE PHENOTYPIC STABILITY
Sherwood J, Bertrand J, Dell'Accio F, Papy T
 
01-01-2017
Chapter 7 Regenerative Medicine and Tissue Engineering
Luyten FP, De Bari C, Dell'Accio F
In Kelley and Firestein's Textbook of Rheumatology, Elsevier 90-105.e4.  
01-01-2017

2016

OP0072 Inhibition of Notch1 Promotes Hedgehog Signaling in A HES1-Dependent Manner and Exacerbates Experimental Osteoarthritis
Lin NY, Distler A, Beyer C, Philipi-Schöbinger A, Stock M, Niemeier A, Dell'Accio F, Schett G et al.
 
01-06-2016
WNT16 antagonizes excessive canonical WNT activation and protects cartilage in osteoarthritis
Thomas BL, Nalesso G, Yu J, Addimanda O, Sherwood J, Dale L, Schett G, Zwerina J et al.
Osteoarthritis and Cartilage, Elsevier vol. 24 
01-04-2016
Pharmacological blockade of CAMKII is detrimental for osteoarthritis progression
Nalesso G, Wagner K, Bertrand J, Sherwood JC, Thomas BL, Eldridge SE, Pitzalis C, Dell'Accio F
 
01-04-2016
Activation of the transient receptor potential cation channel TRPC6 is required for chondrocyte phenotypic stability
Sherwood J, Bertrand J, Seidemann M, Dell'Accio F, Pap T
 
01-04-2016
MMP3 cleaves agrin in cartilage and reduces its chondrogenic potency
Eldridge SE, Petrycki E, Pitzalis C, Whiteford J, Dell'Accio F
 
01-04-2016
Inhibition of Notch1 promotes hedgehog signalling in a HES1-dependent manner in chondrocytes and exacerbates experimental osteoarthritis
Lin N-Y, Distler A, Beyer C, Philipi-Schöbinger A, Breda S, Dees C, Stock M, Tomcik M et al.
Annals of The Rheumatic Diseases, Elsevier vol. 75 (11), 2037-2044.  
05-02-2016
Maintenance of Chondrocyte Phenotypic Stability By TRPC6 Calcium Channel Activity
Sherwood J, Bertrand J, Dell'Accio F, Pap T
 
01-01-2016
Regenerative Medicine and Tissue Engineering
Luyten FP, De Bari C, Dell'Accio F
In Kelley and Firestein S Textbook of Rheumatology Volumes 1 2 Tenth Edition 90-105.e4.  
01-01-2016

2015

A homeostatic function of CXCR2 signalling in articular cartilage.
Sherwood J, Bertrand J, Nalesso G, Poulet B, Pitsillides A, Brandolini L, Karystinou A, De Bari C et al.
Ann Rheum Dis vol. 74 (12), 2207-2215.  
01-12-2015
Neutrophil-derived microvesicles enter cartilage and protect the joint in inflammatory arthritis
Headland SE, Jones HR, Norling LV, Kim A, Souza PR, Corsiero E, Gil CD, Nerviani A et al.
Science Translational Medicine, American Association For The Advancement of Science (Aaas) vol. 7 (315) 
25-11-2015
Agrin mediates chondrocyte homeostasis and requires both LRP4 and α-dystroglycan to enhance cartilage formation in vitro and in vivo
Eldridge S, Nalesso G, Ismail H, Vicente-Greco K, Kabouridis P, Ramachandran M, Niemeier A, Herz J et al.
Annals of The Rheumatic Diseases, Elsevier vol. 75 (6), 1228-1235.  
19-08-2015
Syndecan-4 regulates chondrocyte extracellular matrix architecture and modulates WNT3A-induced matrix remodeling
Clarke CK, Hansen U, Stange R, Echtermeyer F, Dell’Accio F, Pap T, Bertrand J
 
01-04-2015
Obesity does not negatively influence cartilage repair or cause osteoarthritis in DBA/1 mice
Wei W, Bastiaansen-Jenniskens YM, Bos KP, Verhaar JA, Zuurmond A-M, Dell'Accio F, Van Osch GJ
 
01-04-2015
The acute response to joint destabilisation is differentially regulated between male and female mice
Driscoll C, Watt FE, Dell'Accio F, Vincent TL
 
01-04-2015
TRPC6 plays a role in CXCR2-mediated chondrocyte phenotypic stability
Sherwood J, Bertrand J, Dell'Accio F, Pap T
 
01-04-2015
A4.11 Syndecan-4 is an important player in regulating the WNT signalling pathway in articular cartilage
Clarke C, Held A, Stange R, Nalesso G, Sherwood J, Hansen U, Godmann L, Echtermeyer F et al.
 
01-03-2015
PPARγ/mTOR signalling: striking the right balance in cartilage homeostasis
Dell'Accio F, Sherwood J
Annals of The Rheumatic Diseases, Elsevier vol. 74 (3), 477-479.  
14-01-2015
The Role of TRPC6 in CXCR2-Mediated Chondrocyte Phenotypic Stability
Sherwood J, Bertrand J, Dell'Accio F, Pap T
 
01-01-2015

2014

Analyses on the mechanisms that underlie the chondroprotective properties of calcitonin.
Greco KV, Nalesso G, Kaneva MK, Sherwood J, Iqbal AJ, Moradi-Bidhendi N, Dell'Accio F, Perretti M
Biochem Pharmacol vol. 91 (3), 348-358.  
01-10-2014
Articular Chondroprogenitor Cells Maintain Chondrogenic Potential but Fail to Form a Functional Matrix When Implanted Into Muscles of SCID Mice
Marcus P, De Bari C, Dell’Accio F, Archer CW
Cartilage, Sage Publications vol. 5 (4), 231-240.  
03-07-2014
Cellular and molecular mechanisms of cartilage damage and repair
Sherwood JC, Bertrand J, Eldridge SE, Dell’Accio F
Drug Discovery Today, Elsevier vol. 19 (8), 1172-1177.  
28-05-2014
A novel mechanism for protecting the arthritic joint: microparticles deliver Annexin A1 into cartilage (146.8)
Headland S, Norling L, Patel H, Dalli J, Kelly S, Pitzalis C, Dell'Accio F, Perretti M
 
01-04-2014
Culture expansion in low-glucose conditions preserves chondrocyte differentiation and enhances their subsequent capacity to form cartilage tissue in three-dimensional culture.
Heywood HK, Nalesso G, Lee DA, Dell'accio F
Biores Open Access vol. 3 (1), 9-18.  
01-02-2014
WNT16 SUPPORTS THE PHENOTYPE OF THE SUPERFICIAL ZONE CELLS IN CARTILAGE
Thomas BL, Nalesso G, Sherwood J, Bertrand J, Achan P, Pitzalis C, Dell'Accio F
 
01-01-2014
WNT16 IS INDUCED BY OXIDATIVE STRESS FOLLOWING CARTILAGE INJURY AND CONTRIBUTES TO CARTILAGE HOMEOSTASIS IN OSTEOARTHRITIS
Nalesso G, Thomas BL, Sherwood J, Schett G, Dale L, Addimanda O, Eltawil N, Pitzalis C et al.
 
01-01-2014
The WNT/CaMKII pathway is activated in human and experimental osteoarthritis and promotes chondrocyte de-differentiation
Nalesso G, Thomas B, Wagner K, Bertrand J, Sherwood J, Eldridge S, Pap T, Achan P et al.
 
01-01-2014
Agrin expression is downregulated in OA and is required for chondrocyte differentiation
Eldridge S, Vicente-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F
 
01-01-2014
Syndecan-4 Regulates Chondrocyte Phenotype and Cartilage Homeostasis Via the WNT Signaling Pathway.
Clarke CK, Held A, Stange R, Hansen U, Godmann L, Bertrand J, Pap T, Nalesso G et al.
Arthritis & Rheumatology vol. 66, S1289-S1290.  
01-01-2014

2013

Wnt5a/CaMKII pathway is activated in osteoarthritis and promotes loss of chondrocyte phenotype
Nalesso G, Thomas BL, Eldridge SE, Wagner K, Sherwood J, Bertrand J, Pap T, Pitzalis C et al.
 
01-04-2013
SYNDECAN-4 DEFICIENT CHONDROCYTES EXHIBIT ALTERATIONS IN ACTIVATION OF WNT SIGNALING PATHWAYS LEADING TO HIGHER PHENOTYPIC STABILITY
Bertrand J, Stange R, Nalesso G, Sherwood J, Godmann L, Echtermeyer F, Dell'Accio F, Pap T
World Congress of the Osteoarthritis-Research-Society-International (OARSI) Philadelphia, PA 18 Apr 2013 - 21 Apr 2013. 
01-04-2013
TARGETING WNT SIGNALLING IN OSTEOARTHRITIS
Dell'Accio F
Annual Meeting of the British-Society-for-Rheumatology and British-Health-Professionals-in-Rheumatology Birmingham, ENGLAND 23 Apr 2013 - 25 Apr 2013. 
01-04-2013
Agrin expression is downregulated in OA and is required for chondrocyte differentiation
Eldridge S, Vicent-Greco K, Nalesso G, Pitzalis C, Perretti M, Kabouridis P, Dell'Accio F
Osteoarthritis and Cartilage, Elsevier vol. 21, s112-s113.  
01-04-2013
Syndecan 4 supports bone fracture repair, but not fetal skeletal development, in mice.
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P et al.
Arthritis Rheum vol. 65 (3), 743-752.  
01-03-2013
SYNDECAN-4 FUNCTION IS ESSENTIAL FOR MATRIX REMODELLING UNDER INFLAMMATORY CONDITIONS, BUT DISPENSABLE DURING EMBRYOGENESIS
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Timmen M, Bruckner P et al.
33rd European Workshop for Rheumatology Research Prague 28 Feb 2013 - 2 Mar 2013. 
01-03-2013
A homoeostatic role for ELR plus CXC chemokine signalling in articular and epiphyseal cartilage
Sherwood J, Nalesso G, Bertrand J, Brandolini L, Achan P, Pitzalis C, Pap T, Dell'Accio F
 
01-01-2013
Influences of Syndecan-2 and 4 on bone fracture repair and foetal skeletal development
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, dell'Accio F, Pap T et al.
 
01-01-2013
THE ROLE OF CXCR2 SIGNALLING IN ARTICULAR CARTILAGE HOMEOSTASIS
Sherwood J, Bertrand J, Nalesso G, Achan P, Pitzalis C, Pap T, Dell'Accio F
 
01-01-2013
THE ROLE OF CXCR2 SIGNALING IN ARTICULAR CARTILAGE HOMEOSTASIS
Sherwood J, Bertrand J, Nalesso G, Achan P, Pitzalis C, Pap T, Dell'Accio F
 
01-01-2013
Neutrophil-Derived Microparticles as Novel Effectors in Joint Disease
Headland SE, Dell'Accio F, Perretti M
 
01-01-2013
A NOVEL ROLE FOR ELR plus CXC CHEMOKINE SIGNALING IN CARTILAGE HOMEOSTASIS
Sherwood J, Nalesso G, Bertrand J, Achan P, Brandolini L, Pap T, Pitzalis C, Dell'Accio F
Annals of The Rheumatic Diseases vol. 71, 161-161.  
01-01-2013

2012

Decreased levels of nucleotide pyrophosphatase phosphodiesterase 1 are associated with cartilage calcification in osteoarthritis and trigger osteoarthritic changes in mice.
Bertrand J, Nitschke Y, Fuerst M, Hermann S, Schäfers M, Sherwood J, Nalesso G, Ruether W et al.
Ann Rheum Dis vol. 71 (7), 1249-1253.  
01-07-2012
AB0126 Regulation of embryonic bone development and fracture repair by SYNDECAN-4
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Dell'Accio F, Pap T et al.
Annals of The Rheumatic Diseases, Elsevier vol. 71 
01-06-2012
Mapping pathogenesis of arthritis through small animal models
Vincent TL, Williams RO, Maciewicz R, Silman A, Garside P, group FTARUAMW
Rheumatology, Oxford University Press (Oup) vol. 51 (11), 1931-1941.  
16-03-2012
Targeting therapeutics to arthritic joints by antibody specific to post-translationally modified collagen type II
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil NM, Amarrelli A, Al-Kashi A et al.
 
01-02-2012
BONE FRACTURE REPAIR, BUT NOT FETAL SKELETAL DEVELOPMENT IS SUPPORTED BY SYNDECAN-4
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Dell'Accio F, Pap T et al.
 
01-01-2012
ELR plus CXC CHEMOKINE SIGNALLING IN ARTICULAR CHONDROCYTE PHENOTYPIC STABILITY
Sherwood J, Nalesso G, Bertrand J, Pap T, Achan P, Pitzalis C, Dell'Accio F
 
01-01-2012
ELR plus CXC CHEMOKINE SIGNALLING IN CARTILAGE HOMEOSTASIS
Sherwood J, Nalesso G, Bertrand J, Achan P, Brandolini L, Pap T, Pitzalis C, Dell'Accio F
 
01-01-2012
Syndecan-4 Regulates Activation of WNT Signaling in Chondrocytes.
Bertrand J, Stange R, Nalesso G, Sherwood J, Godmann L, Echtermeyer F, Dell'Accio F, Pap T
 
01-01-2012
SYNDECAN-4 IS CRITICALLY INVOLVED IN INFLAMMATORY DRIVEN BONE FRACTURE REPAIR, BUT NOT FETAL SKELETAL DEVELOPMENT
Bertrand J, Stange R, Hidding H, Echtermeyer F, Nalesso G, Godmann L, Dell'Accio F, Pap T et al.
 
01-01-2012
ELR plus CXC chemokine signaling is required for phenotypic stability of human articular chondrocytes
Sherwood J, Nalesso G, Bertrand J, Pap T, Achan P, Pitzalis C, Dell'Accio F
 
01-01-2012
WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways
Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F
 
01-01-2012
Inhibition of Notch Signaling Increases the Severity of Experimental Osteoarthritis
Lin N-Y, Distler A, Beyer C, Dees C, Huang J, Dell'Accio F, Distler O, Schett GA et al.
 
01-01-2012

2011

High density micromass cultures of a human chondrocyte cell line: a reliable assay system to reveal the modulatory functions of pharmacological agents.
Greco KV, Iqbal AJ, Rattazzi L, Nalesso G, Moradi-Bidhendi N, Moore AR, Goldring MB, Dell'Accio F et al.
Biochem Pharmacol vol. 82 (12), 1919-1929.  
15-12-2011
3D CULTURES OF C-28/I2 CHONDROCYTES TO STUDY CHONDROCYTE BIOLOGY AND THERAPEUTIC DEVELOPMENT
Greco KV, Moore A, Dell'Accio F, Perretti M
 
01-06-2011
WNT-3A modulates articular chondrocyte phenotype by activating both canonical and noncanonical pathways.
Nalesso G, Sherwood J, Bertrand J, Pap T, Ramachandran M, De Bari C, Pitzalis C, Dell'accio F
J Cell Biol vol. 193 (3), 551-564.  
02-05-2011
Functional mesenchymal stem cell niches in adult mouse knee joint synovium in vivo.
Kurth TB, Dell'accio F, Crouch V, Augello A, Sharpe PT, De Bari C
Arthritis Rheum vol. 63 (5), 1289-1300.  
01-05-2011
Mesenchymal differentiation propensity of a human embryonic stem cell line.
Pringle S, De Bari C, Dell'Accio F, Przyborski S, Cooke MJ, Minger SL, Grigoriadis AE
Cell Prolif vol. 44 (2), 120-127.  
01-04-2011
TARGETING THERAPEUTICS TO ARTHRITIC JOINTS
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D et al.
 
01-04-2011
Biology of bone, cartilage and connectve tissue disease
Nalesso G, Sherwood J, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F
Rheumatology, Oxford University Press (Oup) vol. 50 (suppl_3), iii77-iii77.  
30-03-2011
LOSS OF NPP1 INDUCES CARTILAGE REMODELLING INTO BONE AND OA-LIKE CHANGES IN MICE
Bertrand J, Furst M, Ruther W, Rutsch F, Nitschke Y, Dell'Accio F, Pap T
 
01-03-2011
Functional mesenchymal stem cell niches in the adult knee joint synovium in vivo.
Kurth TB, Dell'accio F, Crouch V, Augello A, Sharpe PT, De Bari C
Arthritis Rheum 
11-01-2011
WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS
Nalesso G, Sherwood J, Ramachandran M, De Bari C, Pitzalis C, Dell'Accio F
 
01-01-2011
Targeting therapeutics to arthritic joints
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Al-Kashi A, Winyard P, Chernajovsky Y et al.
 
01-01-2011
CYTOKINES DOWNREGULATE NPP1 AND THEREFORE INDUCE CARTILAGE MINERALIZATION IN OA
Bertrand J, Nitschke Y, Fuerst M, Ruether W, Rutsch F, Nalesso G, Dell'Accio F, Pap T
Osteoarthritis and Cartilage vol. 19, S99-S99.  
01-01-2011

2010

CXCR1 AND CXCR2 SIGNALLING IS REQUIRED BUT IS NOT SUFFICIENT TO MAINTAIN THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES
Sherwood J, Key S, Achan P, Nalesso G, Pitzalis C, Dell'Accio F
 
01-10-2010
WNT3A MODULATES CHONDROCYTE PHENOTYPE THROUGH ACTIVATION OF BOTH CANONICAL AND NON-CANONICAL PATHWAYS
Nalesso G, Achan P, Pitzalis C, Dell'Accio F
 
01-10-2010
Joint surface defects: clinical course and cellular response in spontaneous and experimental lesions.
Dell'accio F, Vincent TL
Eur Cell Mater vol. 20, 210-217.  
28-09-2010
Human single-chain variable fragment that specifically targets arthritic cartilage.
Hughes C, Faurholm B, Dell'Accio F, Manzo A, Seed M, Eltawil N, Marrelli A, Gould D et al.
Arthritis Rheum vol. 62 (4), 1007-1016.  
01-04-2010
Molecular response of articular cartilage to injury: Wnt signaling in an in vivo model of joint surface injury
Eltawil N, Pitzalis C, Dell'Accio F
 
01-04-2010
CXCR1/2 signalling in the phenotypic stability of in vitro expanded adult human articular chondrocytes
Sherwood JC, Pitzalis C, Dell'Accio F
 
01-04-2010
Effects of the modulation of Wnt-canonical pathway on the phenotypic stability of human articular chondrocytes
Nalesso G, Eltawil NM, Pitzalis C, Dell'Accio F
 
01-04-2010
CXCR1/2 SIGNALLING IS REQUIRED FOR THE PHENOTYPIC STABILITY OF HUMAN ARTICULAR CHONDROCYTES
Sherwood JC, Achan P, Ramachandran M, Pitzalis C, Dell'Accio F
 
01-04-2010
Concurrent Oral 4 – Basic Science [OP24–OP31]
Gillespie J, Savic S, Wong C, Emery P, Grigg R, McDermott MF, Goodall JC, Wu C et al.
Rheumatology, Oxford University Press (Oup) vol. 49 (suppl_1), i11-i13.  
22-03-2010
Understanding tissue response to cartilage injury
Dell'accio F, Vincent TL
In Regenerative Medicine and Biomaterials For The Repair of Connective Tissues 137-154.  
01-01-2010
Molecular mechanisms of cartilage regeneration
Dell'Accio F
 
01-01-2010

2009

Distinct mesenchymal progenitor cell subsets in the adult human synovium.
Karystinou A, Dell'Accio F, Kurth TBA, Wackerhage H, Khan IM, Archer CW, Jones EA, Mitsiadis TA et al.
Rheumatology (Oxford) vol. 48 (9), 1057-1064.  
01-09-2009
A novel in vivo murine model of cartilage regeneration. Age and strain-dependent outcome after joint surface injury.
Eltawil NM, De Bari C, Achan P, Pitzalis C, Dell'accio F
Osteoarthritis Cartilage vol. 17 (6), 695-704.  
01-06-2009
WNT16 in joint surface injury and osteoarthritis
Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C
 
01-02-2009

2008

Mature Antigen-Experienced T Helper Cells Synthesize and Secrete the B Cell Chemoattractant CXCL13 in the Inflammatory Environment of the Rheumatoid Joint
Manzo A, Vitolo B, Humby F, Caporali R, Jarrossay D, Dell'Accio F, Ciardelli L, Uguccioni M et al.
Arthritis Rheum vol. 58 (11), 3377-3387.  
01-11-2008
Comparative osteogenic transcription profiling of various fetal and adult mesenchymal stem cell sources
Guillot PV, De Bari C, Dell'Accio F, Kurata H, Polak J, Fisk NM
Differentiation vol. 76 (9), 946-957.  
01-11-2008
A mouse model of joint surface injury and repair in mice. Age and strain-dependent outcome
El Tawil NM, De Bari C, Pitzalis C, Dell'Accio F
 
01-09-2008
Identification of the molecular response of articular cartilage to injury, by microarray screening
Dell'Accio F, De Bari C, Eltawil NA, Vanhummelen P, Pitzalis C
Arthritis Rheum vol. 58 (5), 1410-1421.  
01-05-2008
Wnt16 in joint surface injury and osteoarthritis
Dell'Accio F, Eltawil NM, De Bari C, Pitzalis C
 
01-04-2008
A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells.
De Bari C, Dell'Accio F, Karystinou A, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM et al.
Arthritis Rheum vol. 58 (1), 240-250.  
01-01-2008
A biomarker-based mathematical model to predict bone-forming potency of human synovial and periosteal mesenchymal stem cells
De BC, Dell'accio F, Karystinou A, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM et al.
Arthritis Rheum. vol. 58 (1), 240-250.  
01-01-2008
Cell therapy: a challenge in modern medicine.
De Bari C, Dell'accio F
Biomed Mater Eng vol. 18 (1 Suppl), S11-S17.  
01-01-2008

2007

Mesenchymal stem cells in rheumatology: a regenerative approach to joint repair
De Bari C, Dell'Accio F
Clin Sci vol. 113 (7-8), 339-348.  
01-10-2007
Mathematical modeling to predict bone forming potency of human mesenchymal stem cells
de Bari C, Guillot PV, Fisk NM, Jones EA, McGonagle D, Khan IM, Archer CW, Mitsiadis TA et al.
 
01-08-2007
Joint Tissue Engineering
De Bari C, Pitzalis C, Dell'Accio F
In Stem Cell Repair and Regeneration, World Scientific Publishing 107-123.  
01-03-2007

2006

The stem cell niche: a new target in medicine
De Bari C, Pringle S, Pitzalis C, Dell'Accio F
Current Orthopaedic Practice, Wolters Kluwer vol. 17 (5), 398-404.  
01-10-2006
Activation of WNT and BMP signaling in adult human articular cartilage following mechanical injury
DELL'ACCIO F, Pitzalis C, Barone F, Mitsiadis T, De Bari C
Arthritis Research & Therapy vol. 8 (5), R139-R139.  
01-08-2006
The in vivo fate of implanted chondroprogenitor cells in SCID mice
Marcus P, de Bari C, Dell'Accio F, Dowthwaite G, Archer CW
 
01-08-2006
Efficient lentiviral transduction and improved engraftment of human bone marrow mesenchymal cells.
Van Damme A, Thorrez L, Ma L, Vandenburgh H, Eyckmans J, Dell'Accio F, De Bari C, Luyten F et al.
Stem Cells vol. 24 (4), 896-907.  
01-04-2006
Mesenchymal multipotency of adult human periosteal cells demonstrated by single-cell lineage analysis.
De Bari C, Dell'Accio F, Vanlauwe J, Eyckmans J, Khan IM, Archer CW, Jones EA, McGonagle D et al.
Arthritis Rheum vol. 54 (4), 1209-1221.  
01-04-2006
Reparative medicine: from tissue engineering to joint surface regeneration.
De Bari C, Pitzalis C, Dell'Accio F
Regen Med vol. 1 (1), 59-69.  
01-01-2006

2005

Molecular response to cartilage injury
Dell'Accio F, De Bari C, Pitzalis C
Arthritis Research & Therapy, Springer Nature vol. 7 (Suppl 1) 
01-01-2005
Distinct biological properties of human mesenchymal stem cells from different sources
De Bari C, Dell'Accio F, Vanlauwe J, Pitzalis C, Luyten F
Arthritis Research & Therapy, Springer Nature vol. 7 (Suppl 1) 
01-01-2005

2004

Failure of in vitro-differentiated mesenchymal stem cells from the synovial membrane to form ectopic stable cartilage in vivo.
De Bari C, Dell'Accio F, Luyten FP
Arthritis Rheum vol. 50 (1), 142-150.  
01-01-2004

2003

Microenvironment and phenotypic stability specify tissue formation by human articular cartilage-derived cells in vivo
DELL'ACCIO F, Luyten FP, De Bari C
Experimental Cell Research vol. 287 (1), 16-27.  
01-07-2003
Erratum: Bone marrow mesenchymal cells for haemophilia. A gene therapy using retroviral vectors with modified long-terminal repeats (Haemophilia (2003) vol 9 (94-103))
Van Damme A, Chuah MKL, Dell'Accio F, De Bari C, Luyten F, Collen D, Vandendriessche T
Haemophilia vol. 9 (3) 
01-05-2003
Erratum
Journal of Orthopaedic Research®, Wiley vol. 21 (3), 572-572.  
01-05-2003
Morphological and immunocytochemical characterization of cultured fibroblast-like cells derived from adult human synovial membrane.
Vandenabeele F, De Bari C, Moreels M, Lambrichts I, Dell'Accio F, Lippens PL, Luyten FP
Arch Histol Cytol vol. 66 (2), 145-153.  
01-05-2003
Skeletal muscle repair by adult human mesenchymal stem cells from synovial membrane.
De Bari C, Dell'Accio F, Vandenabeele F, Vermeesch JR, Raymackers J-M, Luyten FP
J Cell Biol vol. 160 (6), 909-918.  
17-03-2003
Expanded phenotypically stable chondrocytes persist in the repair tissue and contribute to cartilage matrix formation and structural integration in a goat model of autologous chondrocyte implantation
DELL'ACCIO F, Vanlauwe J, De Bari C, Neys J, Bellemans J, Luyten F
Journal of Orthopaedic Research vol. 21 (1), 123-131.  
01-01-2003
Bone marrow mesenchymal cells for haemophilia A gene therapy using retroviral vectors with modified long-terminal repeats.
Van Damme A, Chuah MKL, Dell'accio F, De Bari C, Luyten F, Collen D, VandenDriessche T
Haemophilia vol. 9 (1), 94-103.  
01-01-2003

2002

Increased expression of nerve growth factor (NGF) and high affinity NGF receptor (p140 TrkA) in human osteoarthritic chondrocytes.
Iannone F, De Bari C, Dell'Accio F, Covelli M, Patella V, Lo Bianco G, Lapadula G
Rheumatology (Oxford) vol. 41 (12), 1413-1418.  
01-12-2002

2001

Skeletal tissue engineering: opportunities and challenges.
Luyten FP, Dell'Accio F, De Bari C
Best Pract Res Clin Rheumatol vol. 15 (5), 759-769.  
01-12-2001
Multipotent mesenchymal stem cells from adult human synovial membrane.
De Bari C, Dell'Accio F, Tylzanowski P, Luyten FP
Arthritis Rheum vol. 44 (8), 1928-1942.  
01-08-2001
Molecular markers predictive of the capacity of expanded human articular chondrocytes to form stable cartilage in vivo
DELL'ACCIO F, Luyten FP, De Bari C
Arthritis & Rheumatism vol. 44 (7), 1608-1619.  
01-07-2001
Human periosteum-derived cells maintain phenotypic stability and chondrogenic potential throughout expansion regardless of donor age.
De Bari C, Dell'Accio F, Luyten FP
Arthritis Rheum vol. 44 (1), 85-95.  
01-01-2001
Interleukin-10 and interleukin-10 receptor in human osteoarthritic and healthy chondrocytes.
Iannone F, De Bari C, Dell'Accio F, Covelli M, Cantatore FP, Patella V, Lo Bianco G, Lapadula G
Clin Exp Rheumatol vol. 19 (2), 139-145.  
01-01-2001

1997

Carpal tunnel syndrome: a review.
Cantatore FP, Dell'Accio F, Lapadula G
Clin Rheumatol vol. 16 (6), 596-603.  
01-11-1997
Isolated thrombocytopenia associated with low dose methotrexate therapy.
Lapadula G, De Bari C, Acquista CA, Dell'Accio F, Covelli M, Iannone F
Clin Rheumatol vol. 16 (4), 429-430.  
01-06-1997

1995

Interleukin-10 in rheumatoid arthritis.
Lapadula G, Iannone F, Dell'Accio F, Covelli M, Pipitone V
Clin Exp Rheumatol vol. 13 (5), 629-632.  
01-01-1995