Dr Ezra Aksoy

Ezra Aksoy
PhD, MSc, BSc, FHEA

Lecturer

William Harvey Research Institute
Faculty of Medicine and Dentistry, Queen Mary University of London

Research

intestinal immunity, intestinal repair and regeneration, host-microbiome interactions, nutrient sensing pathways, phosphoinositol 3-kinase biology, inflammasome

Infectious Disease and Inflammation Models

Interests

Our group is seeking cell signalling targets as biomarkers in immune and epithelial cells in the intestine that impact immune inflammation and regeneration processes. We use in vitro and ex vivo models to test and identify new drug targets associated with process driven inflammation and immune responses.

Publications

Publications of specific relevance to Predictive in vitro Models

2021

Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin M-B, Boulanger CM, Kubota Y, Muller WA, Tooze SA, Nightingale TD, Collinson L, Perretti M, Aksoy E and Nourshargh S (2021). Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Elsevier  Immunity  vol. 54, (9) 1989-2004.e9. 10.1016/j.immuni.2021.07.012
Thibault B, Ramos‐Delgado F, Pons‐Tostivint E, Therville N, Cintas C, Arcucci S, Cassant‐Sourdy S, Reyes‐Castellanos G, Tosolini M, Villard AV, Cayron C, Baer R, Bertrand‐Michel J, Pagan D, Da Mota DF, Yan H, Falcomatà C, Muscari F, Bournet B, Delord J, Aksoy E, Carrier A, Cordelier P, Saur D, Basset C and Guillermet‐Guibert J (2021). Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component. Springer Nature  Embo Molecular Medicine  vol. 13, (7) 10.15252/emmm.202013502

2020

Wood TE, Aksoy E and Hachani A (2020). From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System. Frontiers  Frontiers in Cellular and Infection Microbiology  vol. 10, 10.3389/fcimb.2020.587948
Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E, Alusi G, Hiley C, Ahmed J, Vanhaesebroeck B, Lemoine NR and Wang Y (2020). Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus. Elsevier (Cell Press)  Molecular Therapy  vol. 28, (5) 1263-1275. 10.1016/j.ymthe.2020.02.017

2019

Aksoy E (2019). TLRs toll for Tregs. Oxford University Press (Oup)  Journal of Leukocyte Biology  vol. 106, (6) 1193-1195. 10.1002/jlb.2ce0619-184r
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte J-S, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P and Marot G (2019). Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Elsevier  Cell  vol. 177, (5) 1201-1216.e19. 10.1016/j.cell.2019.03.018
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P and Marot G (2019). Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018)). Cell  vol. 178, (1) 263-263. 10.1016/j.cell.2019.06.017
Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M and Haworth O (2019). Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Elsevier  Cell Reports  vol. 27, (5) 1461-1471.e4. 10.1016/j.celrep.2019.04.014

2018

Aksoy E, Saveanu L and Manoury B (2018). The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function. Frontiers Media Sa  Frontiers in Immunology  vol. 9, 10.3389/fimmu.2018.02574

2015

Simeoli R, Mattace Raso G, Lama A, Pirozzi C, Santoro A, Di Guida F, Sanges M, Aksoy E, Calignano A, D'Arienzo A and Meli R (2015). Preventive and Therapeutic Effects of Lactobacillus Paracasei B21060–Based Synbiotic Treatment on Gut Inflammation and Barrier Integrity in Colitic Mice 1–3. Elsevier  Journal of Nutrition  vol. 145, (6) 1202-1210. 10.3945/jn.114.205989

2014

Bontems P, Aksoy E, Burette A, Segers V, Deprez C, Mascart F and Cadranel S (2014). NF‐κB Activation and Severity of Gastritis in Helicobacter pylori‐Infected Children and Adults. Wiley  Helicobacter  vol. 19, (3) 157-167. 10.1111/hel.12118

2013

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2013). Erratum: Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Springer Nature  Nature Immunology  vol. 14, (8) 877-877. 10.1038/ni0813-877d

2012

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Springer Nature  Nature Immunology  vol. 13, (11) 1045-1054. 10.1038/ni.2426
AKSOY-POISTER E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110´ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol.  vol. 13, (11) 1045-1054. 10.1038/ni.2426

2011

Johnson J, Molle C, Aksoy E, Goldman M, Goriely S and Willems F (2011). A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members. Elsevier  Molecular Immunology  vol. 48, (12-13) 1484-1493. 10.1016/j.molimm.2011.04.006

2010

Langlet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E and Willems F (2010). PKC‐α controls MYD88‐dependent TLR/IL‐1R signaling and cytokine production in mouse and human dendritic cells. Wiley  European Journal of Immunology  vol. 40, (2) 505-515. 10.1002/eji.200939391

2008

Goriely S, Aksoy E, De Wit D, Goldman M and Willems F (2008). Toll-like Receptor Responses in Neonatal Dendritic Cells. Hematology, Immunology and Infectious Disease: Neonatology Questions and Controversies  10.1016/B978-141603158-1.10008-3

2007

Johnson J, Albarani V, Nguyen M, Goldman M, Willems F and Aksoy E (2007). Protein Kinase Cα Is Involved in Interferon Regulatory Factor 3 Activation and Type I Interferon-β Synthesis*. Elsevier  Journal of Biological Chemistry  vol. 282, (20) 15022-15032. 10.1074/jbc.m700421200
Moore F, Buonocore S, Aksoy E, Ouled-Haddou N, Goriely S, Lazarova E, Paulart F, Heirman C, Vaeremans E, Thielemans K, Goldman M and Flamand V (2007). An Alternative Pathway of NF-κB Activation Results in Maturation and T Cell Priming Activity of Dendritic Cells Overexpressing a Mutated IκBα. The American Association of Immunologists  The Journal of Immunology  vol. 178, (3) 1301-1311. 10.4049/jimmunol.178.3.1301

2006

Aksoy E, Albarani V, Nguyen M, Laes J-F, Ruelle J-L, De Wit D, Willems F, Goldman M and Goriely S (2006). Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. American Society of Hematology  Blood  vol. 109, (7) 2887-2893. 10.1182/blood-2006-06-027862

2005

Aksoy E, Berghe WV, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M and Willems F (2005). Inhibition of phosphoinositide 3‐kinase enhances TRIF‐dependent NF‐κB activation and IFN‐β synthesis downstream of Toll‐like receptor 3 and 4. Wiley  European Journal of Immunology  vol. 35, (7) 2200-2209. 10.1002/eji.200425801

2004

Aksoy E, Zouain CS, Vanhoutte F, Fontaine J, Pavelka N, Thieblemont N, Willems F, Ricciardi-Castagnoli P, Goldman M, Capron M, Ryffel B and Trottein F (2004). Double-stranded RNAs from the Helminth Parasite Schistosoma Activate TLR3 in Dendritic Cells*. Elsevier  Journal of Biological Chemistry  vol. 280, (1) 277-283. 10.1074/jbc.m411223200
Vosters O, Beuneu C, Nagy N, Movahedi B, Aksoy E, Salmon I, Pipeleers D, Goldman M and Verhasselt V (2004). CD40 expression on human pancreatic duct cells: role in nuclear factor-kappa B activation and production of pro-inflammatory cytokines. Springer Nature  Diabetologia  vol. 47, (4) 660-668. 10.1007/s00125-004-1363-1
Aksoy E, Goldman M and Willems F (2004). Protein kinase C epsilon: a new target to control inflammation and immune-mediated disorders. Elsevier  The International Journal of Biochemistry & Cell Biology  vol. 36, (2) 183-188. 10.1016/s1357-2725(03)00210-3

2002

Aksoy E, Amraoui Z, Goriely S, Goldman M and Willems F (2002). Critical role of protein kinase C ϵ for lipopolysaccharide‐induced IL‐12 synthesis in monocyte‐derived dendritic cells. Wiley  European Journal of Immunology  vol. 32, (11) 3040-3049. 10.1002/1521-4141(200211)32:11<3040::aid-immu3040>3.0.co;2-m
Tonon S, Goriely S, Aksoy E, Pradier O, Del Giudice G, Trannoy E, Willems F, Goldman M and De Wit D (2002). Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newborns. Wiley  European Journal of Immunology  vol. 32, (11) 3118-3125. 10.1002/1521-4141(200211)32:11<3118::aid-immu3118>3.0.co;2-b
Ismaili J, Rennesson J, Aksoy E, Vekemans J, Vincart B, Amraoui Z, Van Laethem F, Goldman M and Dubois PM (2002). Monophosphoryl Lipid A Activates Both Human Dendritic Cells and T Cells. The American Association of Immunologists  The Journal of Immunology  vol. 168, (2) 926-932. 10.4049/jimmunol.168.2.926

2001

Vanderheyde N, Aksoy E, Amraoui Z, Vandenabeele P, Goldman M and Willems F (2001). Tumoricidal Activity of Monocyte-Derived Dendritic Cells: Evidence for a Caspase-8-Dependent, Fas-Associated Death Domain-Independent Mechanism. The American Association of Immunologists  The Journal of Immunology  vol. 167, (7) 3565-3569. 10.4049/jimmunol.167.7.3565

2000

Willems F, Amraoui Z, Vanderheyde N, Verhasselt V, Aksoy E, Scaffidi C, Peter ME, Krammer PH and Goldman M (2000). Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide. American Society of Hematology  Blood  vol. 95, (11) 3478-3482. 10.1182/blood.v95.11.3478.011k10_3478_3482

Grants

Grants of specific relevance to Predictive in vitro Models
PI3K delta role in dendritic cell antigen processing and presentation to control gut tolerance
Aksoy-Poister E
EUR212,934 European Commission (01-09-2019 - 31-08-2021)
Summary
Generation of a new stratification strategy based on a new biomarker assay for IBD therapy
Aksoy-Poister E
£49,704 Barts charity (16-09-2019 - 30-05-2021)
The role and mechanism of action of p110delta PI3K signalling in gastrointestinal immunity and inflammation.
Aksoy E and Aksoy-Poister E
£551,151 Medical Research Council (31-05-2015 - 15-06-2019)
Summary
Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation
Aksoy-Poister E
£160,000 European Commission (01-05-2017 - 30-04-2019)
Summary
The role and mechanism of action of p110delta PI3K signalling in NOD2-mediated gastrointestinal immunity and inflammation
Aksoy-Poister E
£69,534 WHRI-ACADEMY COFUND Marie Curie (01-07-2015 - 14-01-2017)
Summary
Phosphoinositide 3-kinase isoforms as potential new therapeutic modalities in MSU crystal-mediated inflammasome activation and gout
Aksoy-Poister E
£175,319 Arthritis Research UK (01-12-2011 - 31-12-2014)