Dr Ezra Aksoy
Lecturer
William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London
447732373870School of Medicine & Dentistry, Queen Mary University of London
e.aksoy@qmul.ac.uk
www.qmul.ac.uk/whri/people/academic-staff/items/aksoyezra.html
Research
Interests
Our group is seeking cell signalling targets as biomarkers in phagocytic cells that impact immunity and inflammation. We use in vitro and ex vivo models to test and identify new drug targets associated with process driven inflammation and immune responses.Publications
Publications of specific relevance to Predictive in vitro Models2019
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K#44360#, Carmeliet P and Marot G (2019). Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell vol. 177, (5) 1201-1216.e19. 10.1016/j.cell.2019.03.018Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M and Haworth O (2019). Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Cell Reports vol. 27, (5) 1461-1471.e4. 10.1016/j.celrep.2019.04.0142018
Aksoy E, Saveanu L and Manoury B (2018). The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function. Frontiers Media Sa Frontiers in Immunology vol. 9, 10.3389/fimmu.2018.025742015
Simeoli R, Raso GM, Lama A, Pirozzi C, Santoro A, Di Guida F, Sanges M, Aksoy E, Calignano A, D'Arienzo A and Meli R (2015). Preventive and therapeutic effects of Lactobacillus Paracasei B21060-based synbiotic treatment on gut inflammation and barrier integrity in colitic mice. Journal of Nutrition vol. 145, (6) 1202-1210. 10.3945/jn.114.2059892014
Bontems P, Aksoy E, Burette A, Segers V, Deprez C, Mascart F and Cadranel S (2014). NF-κB Activation and Severity of Gastritis inHelicobacter pylori-Infected Children and Adults. Wiley Helicobacter vol. 19, (3) 157-167. 10.1111/hel.121182012
Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol vol. 13, (11) 1045-1054. 10.1038/ni.2426AKSOY-POISTER E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110´ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol. vol. 13, (11) 1045-1054. 10.1038/ni.2426Grants
PI3K delta role in dendritic cell antigen processing and presentation to control gut toleranceAksoy-Poister E
EUR212,934 European Commission (01-09-2019 - 31-08-2021)
The role and mechanism of action of p110delta PI3K signalling in gastrointestinal immunity and inflammation.Aksoy E and Aksoy-Poister E
£551,151 Medical Research Council (31-05-2015 - 15-06-2019)
Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammationAksoy-Poister E
£160,000 European Commission (01-05-2017 - 30-04-2019)
The role and mechanism of action of p110delta PI3K signalling in NOD2-mediated gastrointestinal immunity and inflammationAksoy-Poister E
£69,534 WHRI-ACADEMY COFUND Marie Curie (01-07-2015 - 14-01-2017)
Phosphoinositide 3-kinase isoforms as potential new therapeutic modalities in MSU crystal-mediated inflammasome activation and goutAksoy-Poister E
£175,319 Arthritis Research UK (01-12-2011 - 31-12-2014)