Dr Ezra Aksoy
Lecturer
The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
intestinal immunity, intestinal repair and regeneration, host-microbiome interactions, nutrient sensing pathways, phosphoinositol 3-kinase biology, inflammasome
Interests
Our group is seeking cell signalling targets as biomarkers in immune and epithelial cells in the intestine that impact immune inflammation and regeneration processes. We use in vitro and ex vivo models to test and identify new drug targets associated with process driven inflammation and immune responses.Publications
2021
Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammationReglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS et al.
Immunity, Elsevier Bv vol. 54 (9), 1989-2004.e9.
01-09-2021
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage componentThibault B, Ramos‐Delgado F, Pons‐Tostivint E, Therville N, Cintas C, Arcucci S, Cassant‐Sourdy S, Reyes‐Castellanos G et al.
Embo Molecular Medicine, Springer Nature vol. 13 (7)
25-05-2021
2020
From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion SystemWood TE, Aksoy E, Hachani A
Frontiers in Cellular and Infection Microbiology, Frontiers vol. 10
19-10-2020
Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia VirusFerguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E et al.
Molecular Therapy, Elsevier (Cell Press) vol. 28 (5), 1263-1275.
27-02-2020
2019
TLRs toll for TregsAksoy E
Journal of Leukocyte Biology, Oxford University Press (Oup) vol. 106 (6), 1193-1195.
17-09-2019
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPRMogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.
Cell, Elsevier vol. 177 (5), 1201-1216.e19.
25-04-2019
Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018))Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J et al.
Cell vol. 178 (1), 263-263.
25-04-2019
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 DegradationSun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X et al.
Cell Reports, Elsevier vol. 27 (5), 1461-1471.e4.
01-04-2019
2018
The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and FunctionAksoy E, Saveanu L, Manoury B
Frontiers in Immunology, Frontiers Media Sa vol. 9
15-11-2018
2015
Preventive and Therapeutic Effects of Lactobacillus Paracasei B21060–Based Synbiotic Treatment on Gut Inflammation and Barrier Integrity in Colitic Mice 1–3Simeoli R, Mattace Raso G, Lama A, Pirozzi C, Santoro A, Di Guida F, Sanges M, Aksoy E et al.
Journal of Nutrition, Elsevier vol. 145 (6), 1202-1210.
29-04-2015
2014
NF‐κB Activation and Severity of Gastritis in Helicobacter pylori‐Infected Children and AdultsBontems P, Aksoy E, Burette A, Segers V, Deprez C, Mascart F, Cadranel S
Helicobacter, Wiley vol. 19 (3), 157-167.
24-03-2014
2013
Erratum: Corrigendum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shockAksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I et al.
Nature Immunology, Springer Nature vol. 14 (8), 877-877.
19-07-2013
2012
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shockAksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM et al.
Nature Immunology, Springer Nature vol. 13 (11), 1045-1054.
30-09-2012
The p110´ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock.AKSOY-POISTER E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM et al.
Nat Immunol. vol. 13 (11), 1045-1054.
01-01-2012
2011
A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family membersJohnson J, Molle C, Aksoy E, Goldman M, Goriely S, Willems F
Molecular Immunology, Elsevier vol. 48 (12-13), 1484-1493.
07-05-2011
2010
PKC‐α controls MYD88‐dependent TLR/IL‐1R signaling and cytokine production in mouse and human dendritic cellsLanglet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E et al.
European Journal of Immunology, Wiley vol. 40 (2), 505-515.
26-01-2010
2008
Toll-like Receptor Responses in Neonatal Dendritic CellsGoriely S, Aksoy E, De Wit D, Goldman M, Willems F
In Hematology, Immunology and Infectious Disease: Neonatology Questions and Controversies 106-134.
01-01-2008
2007
Protein Kinase Cα Is Involved in Interferon Regulatory Factor 3 Activation and Type I Interferon-β Synthesis*Johnson J, Albarani V, Nguyen M, Goldman M, Willems F, Aksoy E
Journal of Biological Chemistry, Elsevier vol. 282 (20), 15022-15032.
12-02-2007
An Alternative Pathway of NF-κB Activation Results in Maturation and T Cell Priming Activity of Dendritic Cells Overexpressing a Mutated IκBαMoore F, Buonocore S, Aksoy E, Ouled-Haddou N, Goriely S, Lazarova E, Paulart F, Heirman C et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 178 (3), 1301-1311.
01-02-2007
2006
Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cellsAksoy E, Albarani V, Nguyen M, Laes J-F, Ruelle J-L, De Wit D, Willems F, Goldman M et al.
Blood, American Society of Hematology vol. 109 (7), 2887-2893.
30-11-2006
2005
Inhibition of phosphoinositide 3‐kinase enhances TRIF‐dependent NF‐κB activation and IFN‐β synthesis downstream of Toll‐like receptor 3 and 4Aksoy E, Berghe WV, Detienne S, Amraoui Z, Fitzgerald KA, Haegeman G, Goldman M, Willems F
European Journal of Immunology, Wiley vol. 35 (7), 2200-2209.
06-06-2005
2004
Double-stranded RNAs from the Helminth Parasite Schistosoma Activate TLR3 in Dendritic Cells*Aksoy E, Zouain CS, Vanhoutte F, Fontaine J, Pavelka N, Thieblemont N, Willems F, Ricciardi-Castagnoli P et al.
Journal of Biological Chemistry, Elsevier vol. 280 (1), 277-283.
01-11-2004
CD40 expression on human pancreatic duct cells: role in nuclear factor-kappa B activation and production of pro-inflammatory cytokinesVosters O, Beuneu C, Nagy N, Movahedi B, Aksoy E, Salmon I, Pipeleers D, Goldman M et al.
Diabetologia, Springer Nature vol. 47 (4), 660-668.
19-03-2004
Protein kinase C epsilon: a new target to control inflammation and immune-mediated disordersAksoy E, Goldman M, Willems F
The International Journal of Biochemistry & Cell Biology, Elsevier vol. 36 (2), 183-188.
01-02-2004
2002
Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: impaired responses in human newbornsTonon S, Goriely S, Aksoy E, Pradier O, Del Giudice G, Trannoy E, Willems F, Goldman M et al.
European Journal of Immunology, Wiley vol. 32 (11), 3118-3125.
16-10-2002
Critical role of protein kinase C ϵ for lipopolysaccharide‐induced IL‐12 synthesis in monocyte‐derived dendritic cellsAksoy E, Amraoui Z, Goriely S, Goldman M, Willems F
European Journal of Immunology, Wiley vol. 32 (11), 3040-3049.
16-10-2002
Monophosphoryl Lipid A Activates Both Human Dendritic Cells and T CellsIsmaili J, Rennesson J, Aksoy E, Vekemans J, Vincart B, Amraoui Z, Van Laethem F, Goldman M et al.
The Journal of Immunology, Oxford University Press (Oup) vol. 168 (2), 926-932.
15-01-2002
2001
Tumoricidal Activity of Monocyte-Derived Dendritic Cells: Evidence for a Caspase-8-Dependent, Fas-Associated Death Domain-Independent MechanismVanderheyde N, Aksoy E, Amraoui Z, Vandenabeele P, Goldman M, Willems F
The Journal of Immunology, Oxford University Press (Oup) vol. 167 (7), 3565-3569.
01-10-2001
2000
Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: inhibition by bisindolylmaleimide.Willems F, Amraoui Z, Vanderheyde N, Verhasselt V, Aksoy E, Scaffidi C, Peter ME, Krammer PH et al.
Blood, American Society of Hematology vol. 95 (11), 3478-3482.
01-06-2000
Grants
Dissecting the antibacterial functions of Campylobacter Type VI Secretion System and effectorsEzra Aksoy
£200,228 Biotechnology and Biological Sciences Research Council
01-03-2025 - 29-02-2028
Uncovering selective role of PI3K signalling in antigen cross presentation in the phagosomeEzra Aksoy
£11,630 Royal Society
01-04-2022 - 31-03-2025
Unravelling Covid-19 immune responses in gut epithelium to target as potential site of immunisationEzra Aksoy
£10,000 February Foundation, The
01-08-2020 - 31-07-2021
Generation of a new stratification strategy based on a new biomarker assay for IBD therapyEzra Aksoy
£49,704 Barts and the London Charity
16-09-2019 - 31-01-2022
Signalling-in-NODS - ‘Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation’Ezra Aksoy
£156,364 EU Commission - Horizon 2020
01-05-2017 - 30-04-2019
The role and mechanism of action of p110delta P13K signalling in gastrointedtinal immunity and inflammationEzra Aksoy
£551,150 MRC Medical Research Council
01-06-2015 - 16-06-2019
The role and mechanism of action of p110delta P13K signalling in gastrointedtinal immunity and inflammationEzra Aksoy
£27,227 EU European Commission - Other
01-06-2015 - 14-12-2018