Publications

Publications of specific relevance to Predictive in vitro Models
2021

Reglero-Real N, Pérez-Gutiérrez L, Yoshimura A, Rolas L, Garrido-Mesa J, Barkaway A, Pickworth C, Saleeb RS, Gonzalez-Nuñez M, Austin-Williams SN, Cooper D, Vázquez-Martínez L, Fu T, De Rossi G, Golding M, Voisin MB, Boulanger CM, Kubota Y, Muller WA, Tooze SA,
Nightingale TD, Collinson L,
Perretti M, Aksoy E and Nourshargh S (2021).
Autophagy modulates endothelial junctions to restrain neutrophil diapedesis during inflammation. Immunity vol. 54, (9) 1989-2004.e9.
10.1016/j.immuni.2021.07.012
Thibault B, Ramos-Delgado F, Pons-Tostivint E, Therville N, Cintas C, Arcucci S, Cassant-Sourdy S, Reyes-Castellanos G, Tosolini M, Villard AV, Cayron C, Baer R, Bertrand-Michel J, Pagan D, Ferreira Da Mota D, Yan H, Falcomatà C, Muscari F, Bournet B, Delord JP, Aksoy E, Carrier A, Cordelier P, Saur D, Basset C and Guillermet-Guibert J (2021).
Pancreatic cancer intrinsic PI3Kα activity accelerates metastasis and rewires macrophage component. Embo Molecular Medicine vol. 13, (7)
10.15252/emmm.2020135022020

Wood TE, Aksoy E and Hachani A (2020).
From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System. Frontiers in Cellular and Infection Microbiology vol. 10,
10.3389/fcimb.2020.587948
Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E, Alusi G, Hiley C, Ahmed J, Vanhaesebroeck B, Lemoine NR and Wang Y (2020).
Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus. Elsevier (Cell Press) Molecular Therapy vol. 28, (5) 1263-1275.
10.1016/j.ymthe.2020.02.0172019

Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P and Marot G (2019).
Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell vol. 177, (5) 1201-1216.e19.
10.1016/j.cell.2019.03.018
Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M and Haworth O (2019).
Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Cell Reports vol. 27, (5) 1461-1471.e4.
10.1016/j.celrep.2019.04.014
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K, Carmeliet P and Marot G (2019).
Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018)). Cell vol. 178, (1) 263-263.
10.1016/j.cell.2019.06.0172018

Aksoy E, Saveanu L and Manoury B (2018).
The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function. Frontiers Media Sa Frontiers in Immunology vol. 9,
10.3389/fimmu.2018.025742015

Simeoli R, Raso GM, Lama A, Pirozzi C, Santoro A, Di Guida F, Sanges M, Aksoy E, Calignano A, D'Arienzo A and Meli R (2015).
Preventive and therapeutic effects of Lactobacillus Paracasei B21060-based synbiotic treatment on gut inflammation and barrier integrity in colitic mice. Journal of Nutrition vol. 145, (6) 1202-1210.
10.3945/jn.114.2059892014

Bontems P, Aksoy E, Burette A, Segers V, Deprez C, Mascart F and Cadranel S (2014).
NF-κB Activation and Severity of Gastritis in Helicobacter pylori-Infected Children and Adults. Helicobacter vol. 19, (3) 157-167.
10.1111/hel.121182013

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2013).
Erratum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (Nature Immunology (2012) 13 (1045-1054)). Nature Immunology vol. 14, (8)
10.1038/ni0813-877d2012

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012).
The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nature Immunology vol. 13, (11) 1045-1054.
10.1038/ni.2426
AKSOY-POISTER E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012).
The p110´ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol. vol. 13, (11) 1045-1054.
10.1038/ni.24262011

Johnson J, Molle C, Aksoy E, Goldman M, Goriely S and Willems F (2011).
A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members. Molecular Immunology vol. 48, (12-13) 1484-1493.
10.1016/j.molimm.2011.04.0062010

Langlet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E and Willems F (2010).
PKC-α controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells. European Journal of Immunology vol. 40, (2) 505-515.
10.1002/eji.2009393912008

Goriely S, Aksoy E, De Wit D, Goldman M and Willems F (2008).
Toll-like Receptor Responses in Neonatal Dendritic Cells. Hematology, Immunology and Infectious Disease: Neonatology Questions and Controversies 10.1016/B978-141603158-1.10008-32007

Johnson J, Albarani V, Nguyen M, Goldman M, Willems F and Aksoy E (2007).
Protein kinase Cα is involved in interferon regulatory factor 3 activation and type I interferon-β synthesis. Journal of Biological Chemistry vol. 282, (20) 15022-15032.
10.1074/jbc.M700421200
Aksoy E, Albarani V, Nguyen M, Laes JF, Ruelle JL, De Wit D, Willems F, Goldman M and Goriely S (2007).
Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. Blood vol. 109, (7) 2887-2893.
10.1182/blood-2006-06-027862
Moore F, Buonocore S, Aksoy E, Ouled-Haddou N, Goriely S, Lazarova E, Paulart F, Heirman C, Vaeremans E, Thielemans K, Goldman M and Flamand V (2007).
An alternative pathway of NF-κB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IκBα. Journal of Immunology vol. 178, (3) 1301-1311.
10.4049/jimmunol.178.3.13012005

Aksoy E, Berghe WV, Detienne S, Amraoui Z, Fitzgerald KA, Haegemann G, Goldman M and Willems F (2005).
Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4. European Journal of Immunology vol. 35, (7) 2200-2209.
10.1002/eji.200425801
Aksoy E, Zouain CS, Vanhoutte F, Fontaine J, Pavelka N, Thieblemont N, Willems F, Ricciardi-Castagnoli P, Goldman M, Capron M, Ryffel B and Trottein F (2005).
Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. Journal of Biological Chemistry vol. 280, (1) 277-283.
10.1074/jbc.M4112232002004

Vosters O, Beuneu C, Nagy N, Movahedi B, Aksoy E, Salmon I, Pipeleers D, Goldman M and Verhasselt V (2004).
CD40 expression on human pancreatic duct cells: Role in nuclear factor-kappa B activation and production of pro-inflammatory cytokines. Diabetologia vol. 47, (4) 660-668.
10.1007/s00125-004-1363-1
Aksoy E, Goldman M and Willems F (2004).
Protein kinase C epsilon: A new target to control inflammation and immune-mediated disorders. International Journal of Biochemistry and Cell Biology vol. 36, (2) 183-188.
10.1016/S1357-2725(03)00210-32002

Ismaili J, Rennesson J, Aksoy E, Vekemans J, Vincart B, Amraoui Z, Van Laethem F, Goldman M and Dubois PM (2002).
Monophosphoryl lipid A activates both human dendritic cells and T cells. Journal of Immunology vol. 168, (2) 926-932.
10.4049/jimmunol.168.2.926
Tonon S, Goriely S, Aksoy E, Pradier O, Del Giudice G, Trannoy E, Willems F, Goldman M and De Wit D (2002).
Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: Impaired responses in human newborns. European Journal of Immunology vol. 32, (11) 3118-3125.
10.1002/1521-4141(200211)32:11<3118::AID-IMMU3118>3.0.CO;2-B2001

Vanderheyde N, Aksoy E, Amraoui Z, Vandenabeele P, Goldman M and Willems F (2001).
Tumoricidal activity of monocyte-derived dendritic cells: Evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanism. Journal of Immunology vol. 167, (7) 3565-3569.
10.4049/jimmunol.167.7.35652000

Willems F, Amraoui Z, Vanderheyde N, Verhasselt V, Aksoy E, Scaffidi C, Peter ME, Krammer PH and Goldman M (2000).
Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: Inhibition by bisindolylmaleimide. Blood vol. 95, (11) 3478-3482.
10.1182/blood.v95.11.3478.011k10_3478_3482