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Dr Ezra Aksoy

Ezra Aksoy

Lecturer

William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London
447732373870

www.qmul.ac.uk/whri/people/academic-staff/items/aksoyezra.html

Research

Interests

Our group is seeking cell signalling targets as biomarkers in phagocytic cells that impact immunity and inflammation. We use in vitro and ex vivo models to test and identify new drug targets associated with process driven inflammation and immune responses.

Publications of specific relevance to Predictive in vitro Models

Publications

2019

Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K#44360#, Carmeliet P and Marot G (2019). Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell  vol. 177, (5) 1201-1216.e19. 10.1016/j.cell.2019.03.018
Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M and Haworth O (2019). Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Cell Reports  vol. 27, (5) 1461-1471.e4. 10.1016/j.celrep.2019.04.014

2018

Aksoy E, Saveanu L and Manoury B (2018). The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function. Frontiers Media Sa  Frontiers in Immunology  vol. 9, 10.3389/fimmu.2018.02574

2015

Simeoli R, Raso GM, Lama A, Pirozzi C, Santoro A, Di Guida F, Sanges M, Aksoy E, Calignano A, D'Arienzo A and Meli R (2015). Preventive and therapeutic effects of Lactobacillus Paracasei B21060-based synbiotic treatment on gut inflammation and barrier integrity in colitic mice. Journal of Nutrition  vol. 145, (6) 1202-1210. 10.3945/jn.114.205989

2014

Bontems P, Aksoy E, Burette A, Segers V, Deprez C, Mascart F and Cadranel S (2014). NF-κB Activation and Severity of Gastritis inHelicobacter pylori-Infected Children and Adults. Wiley  Helicobacter  vol. 19, (3) 157-167. 10.1111/hel.12118

2012

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol  vol. 13, (11) 1045-1054. 10.1038/ni.2426
AKSOY-POISTER E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110´ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol.  vol. 13, (11) 1045-1054. 10.1038/ni.2426

Grants

Grants of specific relevance to Predictive in vitro Models
PI3K delta role in dendritic cell antigen processing and presentation to control gut tolerance
Aksoy-Poister E
EUR212,934 European Commission (01-09-2019 - 31-08-2021)
Abstract
The role and mechanism of action of p110delta PI3K signalling in gastrointestinal immunity and inflammation.
Aksoy E and Aksoy-Poister E
£551,151 Medical Research Council (31-05-2015 - 15-06-2019)
Abstract


Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation
Aksoy-Poister E
£160,000 European Commission (01-05-2017 - 30-04-2019)
Abstract
The role and mechanism of action of p110delta PI3K signalling in NOD2-mediated gastrointestinal immunity and inflammation
Aksoy-Poister E
£69,534 WHRI-ACADEMY COFUND Marie Curie (01-07-2015 - 14-01-2017)
Abstract