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Dr Ezra Aksoy

Ezra Aksoy

Lecturer

William Harvey Research Institute
School of Medicine & Dentistry, Queen Mary University of London
+44 7732 373870

www.qmul.ac.uk/whri/people/academic-staff/items/aksoyezra.html

Research

Interests

Our group is seeking cell signalling targets as biomarkers in phagocytic cells that impact immunity and inflammation. We use in vitro and ex vivo models to test and identify new drug targets associated with process driven inflammation and immune responses.

Publications

Publications of specific relevance to Predictive in vitro Models

2020

Wood TE, Aksoy E and Hachani A (2020). From Welfare to Warfare: The Arbitration of Host-Microbiota Interplay by the Type VI Secretion System. Frontiers in Cellular and Infection Microbiology  vol. 10, 10.3389/fcimb.2020.587948
Ferguson MS, Chard Dunmall LS, Gangeswaran R, Marelli G, Tysome JR, Burns E, Whitehead MA, Aksoy E, Alusi G, Hiley C, Ahmed J, Vanhaesebroeck B, Lemoine NR and Wang Y (2020). Transient Inhibition of PI3Kδ Enhances the Therapeutic Effect of Intravenous Delivery of Oncolytic Vaccinia Virus. Elsevier (Cell Press)  Molecular Therapy  vol. 28, (5) 1263-1275. 10.1016/j.ymthe.2020.02.017

2019

Aksoy E (2019). TLRs toll for Tregs. Journal of Leukocyte Biology  vol. 106, (6) 1193-1195. 10.1002/JLB.2CE0619-184R
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K#44360#, Carmeliet P and Marot G (2019). Erratum: Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR (Cell (2019) 177(5) (1201–1216.e19), (S0092867419302806), (10.1016/j.cell.2019.03.018)). Cell  vol. 178, (1) 10.1016/j.cell.2019.06.017
Mogilenko DA, Haas JT, L'homme L, Fleury S, Quemener S, Levavasseur M, Becquart C, Wartelle J, Bogomolova A, Pineau L, Molendi-Coste O, Lancel S, Dehondt H, Gheeraert C, Melchior A, Dewas C, Nikitin A, Pic S, Rabhi N, Annicotte JS, Oyadomari S, Velasco-Hernandez T, Cammenga J, Foretz M, Viollet B, Vukovic M, Villacreces A, Kranc K#44360#, Carmeliet P and Marot G (2019). Metabolic and Innate Immune Cues Merge into a Specific Inflammatory Response via the UPR. Cell  vol. 177, (5) 1201-1216.e19. 10.1016/j.cell.2019.03.018
Sun D, Stopka-Farooqui U, Barry S, Aksoy E, Parsonage G, Vossenkämper A, Capasso M, Wan X, Norris S, Marshall JL, Clear A, Gribben J, MacDonald TT, Buckley CD, Korbonits M and Haworth O (2019). Aryl Hydrocarbon Receptor Interacting Protein Maintains Germinal Center B Cells through Suppression of BCL6 Degradation. Cell Reports  vol. 27, (5) 1461-1471.e4. 10.1016/j.celrep.2019.04.014

2018

Aksoy E, Saveanu L and Manoury B (2018). The Isoform Selective Roles of PI3Ks in Dendritic Cell Biology and Function. Frontiers Media Sa  Frontiers in Immunology  vol. 9, 10.3389/fimmu.2018.02574

2015

Simeoli R, Raso GM, Lama A, Pirozzi C, Santoro A, Di Guida F, Sanges M, Aksoy E, Calignano A, D'Arienzo A and Meli R (2015). Preventive and therapeutic effects of Lactobacillus Paracasei B21060-based synbiotic treatment on gut inflammation and barrier integrity in colitic mice. Journal of Nutrition  vol. 145, (6) 1202-1210. 10.3945/jn.114.205989

2014

Bontems P, Aksoy E, Burette A, Segers V, Deprez C, Mascart F and Cadranel S (2014). NF-κB Activation and Severity of Gastritis in Helicobacter pylori-Infected Children and Adults. Helicobacter  vol. 19, (3) 157-167. 10.1111/hel.12118

2013

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2013). Erratum: The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock (Nature Immunology (2012) 13 (1045-1054)). Nature Immunology  vol. 14, (8) 10.1038/ni0813-877d

2012

Aksoy E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno-Martin I, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110δ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nature Immunology  vol. 13, (11) 1045-1054. 10.1038/ni.2426
AKSOY-POISTER E, Taboubi S, Torres D, Delbauve S, Hachani A, Whitehead MA, Pearce WP, Berenjeno IM, Nock G, Filloux A, Beyaert R, Flamand V and Vanhaesebroeck B (2012). The p110´ isoform of the kinase PI(3)K controls the subcellular compartmentalization of TLR4 signaling and protects from endotoxic shock. Nat Immunol.  vol. 13, (11) 1045-1054. 10.1038/ni.2426

2011

Johnson J, Molle C, Aksoy E, Goldman M, Goriely S and Willems F (2011). A conventional protein kinase C inhibitor targeting IRF-3-dependent genes differentially regulates IL-12 family members. Molecular Immunology  vol. 48, (12-13) 1484-1493. 10.1016/j.molimm.2011.04.006

2010

Langlet C, Springael C, Johnson J, Thomas S, Flamand V, Leitges M, Goldman M, Aksoy E and Willems F (2010). PKC-α controls MYD88-dependent TLR/IL-1R signaling and cytokine production in mouse and human dendritic cells. European Journal of Immunology  vol. 40, (2) 505-515. 10.1002/eji.200939391

2008

Goriely S, Aksoy E, De Wit D, Goldman M and Willems F (2008). Toll-Like Receptor Responses in Neonatal Dendritic Cells. Hematology, Immunology and Infectious Disease: Neonatology Questions and Controversies  10.1016/B978-141603158-1.10008-3

2007

Johnson J, Albarani V, Nguyen M, Goldman M, Willems F and Aksoy E (2007). Protein kinase Cα is involved in interferon regulatory factor 3 activation and type I interferon-β synthesis. Journal of Biological Chemistry  vol. 282, (20) 15022-15032. 10.1074/jbc.M700421200
Aksoy E, Albarani V, Nguyen M, Laes JF, Ruelle JL, De Wit D, Willems F, Goldman M and Goriely S (2007). Interferon regulatory factor 3-dependent responses to lipopolysaccharide are selectively blunted in cord blood cells. Blood  vol. 109, (7) 2887-2893. 10.1182/blood-2006-06-027862
Moore F, Buonocore S, Aksoy E, Ouled-Haddou N, Goriely S, Lazarova E, Paulart F, Heirman C, Vaeremans E, Thielemans K, Goldman M and Flamand V (2007). An alternative pathway of NF-κB activation results in maturation and T cell priming activity of dendritic cells overexpressing a mutated IκBα. Journal of Immunology  vol. 178, (3) 1301-1311. 10.4049/jimmunol.178.3.1301

2005

Aksoy E, Berghe WV, Detienne S, Amraoui Z, Fitzgerald KA, Haegemann G, Goldman M and Willems F (2005). Inhibition of phosphoinositide 3-kinase enhances TRIF-dependent NF-κB activation and IFN-β synthesis downstream of Toll-like receptor 3 and 4. European Journal of Immunology  vol. 35, (7) 2200-2209. 10.1002/eji.200425801
Aksoy E, Zouain CS, Vanhoutte F, Fontaine J, Pavelka N, Thieblemont N, Willems F, Ricciardi-Castagnoli P, Goldman M, Capron M, Ryffel B and Trottein F (2005). Double-stranded RNAs from the helminth parasite Schistosoma activate TLR3 in dendritic cells. Journal of Biological Chemistry  vol. 280, (1) 277-283. 10.1074/jbc.M411223200

2004

Vosters O, Beuneu C, Nagy N, Movahedi B, Aksoy E, Salmon I, Pipeleers D, Goldman M and Verhasselt V (2004). CD40 expression on human pancreatic duct cells: Role in nuclear factor-kappa B activation and production of pro-inflammatory cytokines. Diabetologia  vol. 47, (4) 660-668. 10.1007/s00125-004-1363-1
Aksoy E, Goldman M and Willems F (2004). Protein kinase C epsilon: A new target to control inflammation and immune-mediated disorders. International Journal of Biochemistry and Cell Biology  vol. 36, (2) 183-188. 10.1016/S1357-2725(03)00210-3

2002

Aksoy E, Amraoui Z, Goriely S, Goldman M and Willems F (2002). Critical role of protein kinase C ε for lipopolysaccharide-induced IL-12 synthesis in monocyte-derived dendritic cells. European Journal of Immunology  vol. 32, (11) 3040-3049. 10.1002/1521-4141(200211)32:11<3040::AID-IMMU3040>3.0.CO;2-M
Ismaili J, Rennesson J, Aksoy E, Vekemans J, Vincart B, Amraoui Z, Van Laethem F, Goldman M and Dubois PM (2002). Monophosphoryl lipid A activates both human dendritic cells and T cells. Journal of Immunology  vol. 168, (2) 926-932. 10.4049/jimmunol.168.2.926
Tonon S, Goriely S, Aksoy E, Pradier O, Del Giudice G, Trannoy E, Willems F, Goldman M and De Wit D (2002). Bordetella pertussis toxin induces the release of inflammatory cytokines and dendritic cell activation in whole blood: Impaired responses in human newborns. European Journal of Immunology  vol. 32, (11) 3118-3125. 10.1002/1521-4141(200211)32:11<3118::AID-IMMU3118>3.0.CO;2-B

2001

Vanderheyde N, Aksoy E, Amraoui Z, Vandenabeele P, Goldman M and Willems F (2001). Tumoricidal activity of monocyte-derived dendritic cells: Evidence for a caspase-8-dependent, Fas-associated death domain-independent mechanism. Journal of Immunology  vol. 167, (7) 3565-3569. 10.4049/jimmunol.167.7.3565

2000

Willems F, Amraoui Z, Vanderheyde N, Verhasselt V, Aksoy E, Scaffidi C, Peter ME, Krammer PH and Goldman M (2000). Expression of c-FLIP(L) and resistance to CD95-mediated apoptosis of monocyte-derived dendritic cells: Inhibition by bisindolylmaleimide. Blood  vol. 95, (11) 3478-3482. 10.1182/blood.v95.11.3478.011k10_3478_3482

Grants

Grants of specific relevance to Predictive in vitro Models
PI3K delta role in dendritic cell antigen processing and presentation to control gut tolerance
Aksoy-Poister E
EUR212,934 European Commission (01-09-2019 - 31-08-2021)
Summary
Generation of a new stratification strategy based on a new biomarker assay for IBD therapy
Aksoy-Poister E
£49,704 Barts charity (16-09-2019 - 30-05-2021)


The role and mechanism of action of p110delta PI3K signalling in gastrointestinal immunity and inflammation.
Aksoy E and Aksoy-Poister E
£551,151 Medical Research Council (31-05-2015 - 15-06-2019)
Summary
Investigation of the role and mechanism of action of NOD2-mediated isoform selective PI3K signalling in gut immunity and inflammation
Aksoy-Poister E
£160,000 European Commission (01-05-2017 - 30-04-2019)
Summary
The role and mechanism of action of p110delta PI3K signalling in NOD2-mediated gastrointestinal immunity and inflammation
Aksoy-Poister E
£69,534 WHRI-ACADEMY COFUND Marie Curie (01-07-2015 - 14-01-2017)
Summary
Phosphoinositide 3-kinase isoforms as potential new therapeutic modalities in MSU crystal-mediated inflammasome activation and gout
Aksoy-Poister E
£175,319 Arthritis Research UK (01-12-2011 - 31-12-2014)