Mr Dillon Popat
PhD Student
Molecular Endocrinology, The William Harvey Research Institute
Queen Mary University of London
Queen Mary University of London
Research
Adrenal, GPCR, Pharmacology, Endocrinology
PhD Title
Molecular characterisation of the MC2R/MRAP complex and its antagonists for the treatment of ACTH excess in pituitary and neuroendocrine tumoursInterests
My project involves the development of novel antagonists to the hormone ACTH which acts on the adrenal gland. I want to use advanced in vitro models to recapitulate the adrenal. Using this model I will test out the antagonists and do subsequent hormone ELISA's or use advanced mass spectrometry techniques.GPCR Biology, Adrenal biology, biosensor assays, ELISA, hormone profiling.
Publications
2024
Primary unilateral macronodular adrenal hyperplasia with concomitant glucocorticoid and androgen excess and KDM1A inactivationElhassan YS, Appenzeller S, Landwehr L-S, Lippert J, Popat D, Gilligan LC, Abdi L, Goh E et al.
European Journal of Endocrinology, Oxford University Press (Oup) vol. 191 (3), 334-344.
22-08-2024
A Novel Maternally Inherited GNAS Variant in a Family With Hyperphagia and Obesity: 3 CasesRamakrishnan A, Popat D, Purushothaman P, Chan LF
Jcem Case Reports, The Endocrine Society vol. 2 (8)
24-07-2024
2022
Identification of a novel specific small-molecule melanocortin-2-receptor antagonistChan L
Endocrine Connections, Bioscientifica vol. 11 (12)
31-10-2022