Nuclear receptor Nur77 and Yin‐Yang 1 synergistically increase mitochondrial abundance and activity in macrophages
Koenis DS, Gogh IJAE, van Loenen PB, Zwart W, Kalkhoven E, de Vries CJM
Febs Letters, Wiley vol. 598 (14), 1715-1729.  
02-06-2024

Efferocyte‐Derived MCTRs Metabolically Prime Macrophages for Continual Efferocytosis via Rac1‐Mediated Activation of Glycolysis
Koenis DS, de Matteis R, Rajeeve V, Cutillas P, Dalli J
Advanced Science, Wiley vol. 11 (7) 
08-12-2023

Stereoselective Synthesis, Pro-resolution, and Anti-inflammatory Actions of RvD5_n-3 DPA
Ervik K, Reinertsen AF, Koenis DS, Dalli J, Hansen TV
Journal of Natural Products, American Chemical Society (Acs) vol. 86 (11), 2546-2553.  
25-10-2023

Deletion of macrophage Gpr101 disrupts their phenotype and function dysregulating host immune responses in sterile and infectious inflammation
Flak MB, Koenis DS, Gonzalez-Nunez M, Chopo-Pizarro A, Dalli J
Biochemical Pharmacology, Elsevier Bv vol. 207, 115348-115348.  
01-01-2023

MCTR3 reprograms arthritic monocytes to upregulate Arginase-1 and exert pro-resolving and tissue-protective functions in experimental arthritis
Pistorius K, Ly L, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J et al.
Ebiomedicine, Elsevier Bv vol. 79, 103974-103974.  
01-05-2022

USP25 promotes pathological HIF-1-driven metabolic reprogramming and is a potential therapeutic target in pancreatic cancer
Nelson JK, Thin MZ, Evan T, Howell S, Wu M, Almeida B, Legrave N, Koenis DS et al.
Nature Communications, Springer Nature vol. 13 (1) 
19-04-2022

MCTR3 reprogramming arthritic monocytes to exert pro-resolving and tissue-protective functions in inflammatory arthritis
Pistorius K, Souza PR, Gomez EA, Koenis DS, Rodriguez AR, Foster J, Sosabowski J, Hopkinson M et al.
 
01-01-2022

Dysregulated Maresin Concentrations in Plasma and Nasal Secretions From Patients With Chronic Rhinosinusitis
Beegun I, Koenis DS, Alusi G, Dalli J
Frontiers in Immunology, Frontiers Media Sa vol. 12 
31-08-2021

Disrupted Resolution Mechanisms Favor Altered Phagocyte Responses in COVID-19
Koenis DS, Beegun I, Jouvene CC, Aguirre GA, Souza PR, Gonzalez-Nunez M, Ly L, Pistorius K et al.
Circulation Research, Ovid Technologies (Wolters Kluwer Health) vol. 129 (4) 
06-08-2021

14,17,18-Trihydroxy-Eicosatetraenoic Acid: A Novel Pro-Resolving Lipid Mediator from Marine Microalgae
Jagusch H, Werner M, Koenis D, Dalli J, Werz O, Pohnert G
Acs Pharmacology &Amp; Translational Science, American Chemical Society (Acs) vol. 4 (3), 1188-1194.  
27-05-2021

S100A9 Links Inflammation and Repair in Myocardial Infarction
Marinković G, Koenis DS, de Camp L, Jablonowski R, Graber N, de Waard V, de Vries CJ, Goncalves I et al.
Circulation Research, Wolters Kluwer vol. 127 (5), 664-676.  
21-05-2020

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis.
van der Stoel M, Schimmel L, Nawaz K, van Stalborch A-M, de Haan A, Klaus-Bergmann A, Valent ET, Koenis DS et al.
Journal of Cell Science 
01-01-2020

GPR101 mediates the pro-resolving actions of RvD5n-3 DPA in arthritis and infections
Flak MB, Koenis DS, Sobrino A, Smith J, Pistorius K, Palmas F, Dalli J
Journal of Clinical Investigation, American Society For Clinical Investigation vol. 130 (1), 359-373.  
03-12-2019

Nur77 variants solely comprising the amino-terminal domain activate hypoxia-inducible factor-1α and affect bone marrow homeostasis in mice and humans
Koenis DS, Medzikovic L, Vos M, Beldman TJ, van Loenen PB, van Tiel CM, Hamers AAJ, Otermin Rubio I et al.
Journal of Biological Chemistry, Elsevier vol. 293 (39), 15070-15083.  
15-08-2018

Nuclear Receptor Nur77 Limits the Macrophage Inflammatory Response through Transcriptional Reprogramming of Mitochondrial Metabolism
Koenis DS, Medzikovic L, van Loenen PB, van Weeghel M, Huveneers S, Vos M, Gogh IJE-V, Van den Bossche J et al.
Cell Reports, Elsevier vol. 24 (8), 2127-2140.e7.  
01-08-2018

Nur77 protects against adverse cardiac remodelling by limiting Neuropeptide Y signalling in the sympathoadrenal-cardiac axis.
Medzikovic L, van Roomen C, Baartscheer A, van Loenen PB, de Vos J, Bakker ENTP, Koenis DS, Damanafshan A et al.
Cardiovasc Res 
30-05-2018

Structural and cellular mechanisms of peptidyl-prolyl isomerase Pin1-mediated enhancement of Tissue Factor gene expression, protein half-life, and pro-coagulant activity
Kurakula K, Koenis DS, Herzik MA, Liu Y, Craft JW, van Loenen PB, Vos M, Tran MK et al.
Haematologica, Ferrata Storti Foundation (Haematologica) vol. 103 (6), 1073-1082.  
15-03-2018

Identification of the ER-resident E3 ubiquitin ligase RNF145 as a novel LXR-regulated gene
Cook ECL, Nelson JK, Sorrentino V, Koenis D, Moeton M, Scheij S, Ottenhoff R, Bleijlevens B et al.
Plos One, Public Library of Science (Plos) vol. 12 (2) 
23-02-2017

EEPD1 Is a Novel LXR Target Gene in Macrophages Which Regulates ABCA1 Abundance and Cholesterol Efflux
Nelson JK, Koenis DS, Scheij S, Cook ECL, Moeton M, Santos A, Lobaccaro J-MA, Baron S et al.
Arteriosclerosis Thrombosis and Vascular Biology, Wolters Kluwer vol. 37 (3), 423-432.  
12-01-2017

Nur77-deficiency in bone marrow-derived macrophages modulates inflammatory responses, extracellular matrix homeostasis, phagocytosis and tolerance
Hamers AAJ, Argmann C, Moerland PD, Koenis DS, Marinković G, Sokolović M, de Vos AF, de Vries CJM et al.
Bmc Genomics, Springer Nature vol. 17 (1) 
01-03-2016

Protein–protein interactions of the LIM-only protein FHL2 and functional implication of the interactions relevant in cardiovascular disease
Tran MK, Kurakula K, de Vries CJM
Biochimica Et Biophysica Acta, Elsevier vol. 1863 (2), 219-228.  
06-11-2015

LIM-Only Protein FHL2 Is a Positive Regulator of Liver X Receptors in Smooth Muscle Cells Involved in Lipid Homeostasis
Kurakula K, Sommer D, Sokolovic M, Moerland PD, van Loenen PB, Koenis DS, Zelcer N
Molecular and Cellular Biology, Taylor & Francis vol. 35 (1), 52-62.  
01-01-2015

NR4A nuclear receptors are orphans but not lonesome
Kurakula K, Koenis DS, van Tiel CM, de Vries CJM
Biochimica Et Biophysica Acta, Elsevier vol. 1843 (11), 2543-2555.  
27-06-2014

Dual function of Pin1 in NR4A nuclear receptor activation: Enhanced activity of NR4As and increased Nur77 protein stability
van Tiel CM, Kurakula K, Koenis DS, van der Wal E
Biochimica Et Biophysica Acta, Elsevier vol. 1823 (10), 1894-1904.  
10-07-2012

DLC1 is a direct target of activated YAP/TAZ that drives collective migration and sprouting angiogenesis

In Biorxiv