Dr Charalampos (Babis) Rallis

Charalampos (Babis) Rallis

Reader In Genetics, Genomics and Fundamental Cell Biology

School of Biological and Behavioural Sciences
Queen Mary University of London
07814 221753
www.rallislab.org

Research

Ageing, Senescence, Cancer, Eaxtracellular matrix, Nutrient perception, Gene expression

Interests

We study gene and protein networks implicated in cellular fitness and metabolism, neurodegeneration, cancer and ageing. Our aim is to elucidate the molecular mechanisms and principles behind senescence and lifespan and apply this knowledge for the amelioration of age-related diseases. We utilise cell-based systems and phenocopy in vivo normal and pathological situations using human neuronal and fibroblastic systems. We have established ageing and neurodegeneration models and can intervene genetically and pharmacologically.

Publications

solid heart iconPublications of specific relevance to Predictive in vitro Models

2025

Rapalink-1 reveals TOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating TOR activity and lifespan in fission yeast.
Rallis C
Communications Biology, Nature Research vol. 8, 1364-1364.  
29-09-2025
Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast
Alao J-P, Kumar J, Stamataki D, Rallis C
Microbial Cell, Shared Science Publishers Og vol. 12 (1) 
24-06-2025

2023

Correction: Islam, R.A.; Rallis, C. Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging. Epigenomes 2023, 7, 17
Islam RA
Epigenomes, Mdpi vol. 7 (4) 
26-10-2023
The longevity and reversibility of quiescence in Schizosaccharomyces pombe are dependent upon the HIRA histone chaperone
Gal C, Cochrane GA, Morgan BA
Cell Cycle, Taylor & Francis vol. 22 (17), 1921-1936.  
27-08-2023
Ribosomal Biogenesis and Heterogeneity in Development, Disease, and Aging
Islam RA, Rallis C
Epigenomes, Mdpi vol. 7 (3) 
11-08-2023
Interplays of AMPK and TOR in Autophagy Regulation in Yeast
Alao J-P, Legon L, Dabrowska A, Tricolici A-M
Cells, Mdpi vol. 12 (4) 
04-02-2023

2022

Nutrient-Response Pathways in Healthspan and Lifespan Regulation
Dabrowska A, Kumar J, Rallis C
Cells, Mdpi vol. 11 (9) 
06-05-2022

2021

Increased fidelity of protein synthesis extends lifespan
Martinez-Miguel VE, Lujan C, Espie--Caullet T, Martinez-Martinez D, Moore S, Gonzalez S, Brown AEX, Halic M et al.
Cell Metabolism, Elsevier vol. 33 (11), 2288-2300.e12.  
14-09-2021
Genome-wide screens in yeast models towards understanding chronological lifespan regulation
Legon L, Rallis C
Briefings in Functional Genomics, Oxford University Press (Oup) vol. 21 (1), 4-12.  
17-03-2021
Crosstalk between the mTOR and DNA Damage Response Pathways in Fission Yeast
Alao J-P, Legon L
Cells, Mdpi vol. 10 (2) 
02-02-2021

2020

Amino Acids Whose Intracellular Levels Change Most During Aging Alter Chronological Life Span of Fission Yeast
Rallis C, Mülleder M, Smith G, Au YZ
The Journals of Gerontology Series A, Oxford University Press (Oup) vol. 76 (2), 205-210.  
03-11-2020
Caffeine Stabilises Fission Yeast Wee1 in a Rad24-Dependent Manner but Attenuates Its Expression in Response to DNA Damage
Alao JP, Johansson-Sjölander J, Rallis C
Microorganisms, Mdpi vol. 8 (10) 
30-09-2020
The Target of Rapamycin Signalling Pathway in Ageing and Lifespan Regulation
Bjedov I, Rallis C
Genes, Mdpi vol. 11 (9) 
03-09-2020
The GATA Transcription Factor Gaf1 Represses tRNAs, Inhibits Growth, and Extends Chronological Lifespan Downstream of Fission Yeast TORC1
Rodríguez-López M, Gonzalez S, Hillson O, Tunnacliffe E, Codlin S
Cell Reports, Elsevier vol. 30 (10), 3240-3249.e4.  
01-03-2020

2019

An essential role for dNTP homeostasis following CDK-induced replication stress
Pai C-C, Hsu K-F, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R et al.
Journal of Cell Science, The Company of Biologists vol. 132 (6) 
15-03-2019

2018

Prospects of Pharmacological Interventions to Organismal Aging
Hillson O, Gonzalez S, Rallis C
Biomolecular Concepts, De Gruyter vol. 9 (1), 200-215.  
31-12-2018
Long noncoding RNA repertoire and targeting by nuclear exosome, cytoplasmic exonuclease, and RNAi in fission yeast
Atkinson SR, Marguerat S, Bitton DA, Rodríguez-López M, Rallis C, Lemay J-F, Malecki M, Smialowski P et al.
Rna, Cold Spring Harbor Laboratory vol. 24 (9), 1195-1213.  
18-06-2018
Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast Cells
Ellis DA, Mustonen V, Rodríguez-López M, Rallis C, Bähler J
Genetics, Oxford University Press (Oup) vol. 210 (2), 733-744.  
08-02-2018

2017

RNA metabolism is the primary target of formamide in vivo
Hoyos-Manchado R, Reyes-Martín F, Rallis C, Gamero-Estévez E, Rodríguez-Gómez P, Quintero-Blanco J
Scientific Reports, Springer Nature vol. 7 (1) 
21-11-2017
Erratum: Corrigendum: Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes
Rallis C, Townsend S, Bähler J
Scientific Reports, Springer Nature vol. 7 (1) 
10-07-2017
Genetic interactions and functional analyses of the fission yeast gsk3 and amk2 single and double mutants defective in TORC1-dependent processes
Rallis C, Bähler J
Scientific Reports, Springer Nature vol. 7 (1) 
10-03-2017
Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast
Jeffares DC, Jolly C, Hoti M, Speed D, Shaw L, Rallis C, Bähler J
Nature Communications, Springer Nature vol. 8 (1) 
24-01-2017

2016

Functional and regulatory profiling of energy metabolism in fission yeast
Malecki M, Bitton DA, Rodríguez-López M, Rallis C, Calavia NG, Smith GC
Genome Biology, Springer Nature vol. 17 (1) 
25-11-2016
Php4 Is a Key Player for Iron Economy in Meiotic and Sporulating Cells
Brault A, Rallis C, Normant V, Garant J-M
G3: Genes, Genomes, Genetics, Oxford University Press (Oup) vol. 6 (10), 3077-3095.  
01-10-2016
Spotsizer: High-throughput quantitative analysis of microbial growth
Bischof L, Pevorovsk M, Rallis C, Jeffares DC
Biotechniques, Taylor & Francis vol. 61 (4), 191-201.  
01-10-2016
Identification of nuclear genes affecting 2-Deoxyglucose resistance in Schizosaccharomyces pombe
Vishwanatha A, Rallis C, Subramanyaswamy SB, Bähler J
Fems Yeast Research, Oxford University Press (Oup) vol. 16 (6) 
31-07-2016
Increasing extracellular H2O2 produces a bi-phasic response in intracellular H2O2, with peroxiredoxin hyperoxidation only triggered once the cellular H2O2-buffering capacity is overwhelmed
Tomalin LE, Day AM, Underwood ZE, Smith GR, Pezze PD, Rallis C, Dickinson BC, Bähler J et al.
Free Radical Biology and Medicine, Elsevier vol. 95, 333-348.  
02-03-2016

2015

A central role for TOR signalling in a yeast model for juvenile CLN3 disease
Bond ME, Brown R, Rallis C, Bähler J
Microbial Cell, Shared Science Publishers Og vol. 2 (12) 
07-12-2015
Cell-based screens and phenomics with fission yeast
Rallis C, Bähler J
Critical Reviews in Biochemistry and Molecular Biology, Taylor & Francis vol. 51 (2), 86-95.  
02-11-2015
Widespread exon skipping triggers degradation by nuclear RNA surveillance in fission yeast
Bitton DA, Atkinson SR, Rallis C, Ellis DA, Chen YYC, Malecki M, Codlin S, Cotobal C et al.
Genome Research, Cold Spring Harbor Laboratory vol. 25 (6), 884-896.  
16-04-2015
The genomic and phenotypic diversity of Schizosaccharomyces pombe
Jeffares DC, Rallis C, Rieux A, Speed D, Převorovský M, Mourier T, Marsellach FX, Iqbal Z et al.
Nature Genetics, Springer Nature vol. 47 (3), 235-241.  
09-02-2015
Parallel Profiling of Fission Yeast Deletion Mutants for Proliferation and for Lifespan During Long-Term Quiescence
Sideri T, Rallis C, Lages BM, Suo F, Rodríguez-López M
G3: Genes, Genomes, Genetics, Oxford University Press (Oup) vol. 5 (1), 145-155.  
01-01-2015

2014

Lithium suppresses Aβ pathology by inhibiting translation in an adult Drosophila model of Alzheimer's disease
Sofola-Adesakin O, Castillo-Quan JI, Rallis C, Bjedov I, Rogers I, Li L, Martinez P, Khericha M
Frontiers in Aging Neuroscience, Frontiers vol. 6 
30-07-2014
LaSSO, a strategy for genome-wide mapping of intronic lariats and branch points using RNA-seq
Bitton DA, Rallis C, Jeffares DC, Smith GC, Codlin S, Marguerat S
Genome Research, Cold Spring Harbor Laboratory vol. 24 (7), 1169-1179.  
07-04-2014
Systematic screen for mutants resistant to TORC1 inhibition in fission yeast reveals genes involved in cellular ageing and growth
Rallis C, López-Maury L, Georgescu T, Bähler J
Biology Open, The Company of Biologists vol. 3 (2), 161-171.  
17-01-2014

2013

Inhibition of TORC1 signaling and increased lifespan: gained in translation?
Rallis C, Bähler J
Aging, Impact Journals vol. 5 (5), 335-336.  
21-05-2013
TORC1 signaling inhibition by rapamycin and caffeine affect lifespan, global gene expression, and cell proliferation of fission yeast
Rallis C, Bähler J
Aging Cell, Wiley vol. 12 (4), 563-573.  
02-05-2013

2012

Predicting the Fission Yeast Protein Interaction Network
Pancaldi V, Saraç ÖS, Rallis C, McLean JR, Převorovský M
G3: Genes, Genomes, Genetics, Oxford University Press (Oup) vol. 2 (4), 453-467.  
01-04-2012

2011

Bright days for yeast research
Převorovský M
 
01-01-2011

2010

Cell-autonomous integrin control of Wnt and Notch signalling during somitogenesis
Rallis C, Pinchin SM, Ish-Horowicz D
Development, The Company of Biologists vol. 137 (21), 3591-3601.  
28-09-2010
Integrin-Linked Kinase Is a Functional Mn2+-Dependent Protein Kinase that Regulates Glycogen Synthase Kinase-3β (GSK-3β) Phosphorylation
Maydan M, McDonald PC, Sanghera J, Yan J, Rallis C, Pinchin S, Hannigan GE
Plos One, Public Library of Science (Plos) vol. 5 (8) 
23-08-2010

2009

New tricks for an old-favorite model
Rallis C
 
01-01-2009

2008

Elucidating developmental gene networks
Hanisch A, Vezzaro A, Rallis C
 
01-01-2008

2007

Cell signaling and cancer
Bazigou E, Rallis C
 
01-01-2007
Chickens get their place in the sun
Rallis C
 
01-01-2007

2006

Developmental genomics reaches new heights
Rallis C
 
01-01-2006

2005

Tbx3 can alter limb position along the rostrocaudal axis of the developing embryo
Rallis C, Del Buono J
Development, The Company of Biologists vol. 132 (8), 1961-1970.  
15-04-2005

2003

Tbx5 is required for forelimb bud formation and continued outgrowth
Rallis C, Bruneau BG, Del Buono J, Seidman CE, Seidman JG, Logan MPO
Development, The Company of Biologists vol. 130 (12), 2741-2751.  
15-06-2003

2001

Isolation of the avian homologue of the homeobox gene Mox2 and analysis of its expression pattern in developing somites and limbs
Rallis C, Stamataki D, Pontikakis S
Cells and Development, Elsevier vol. 104 (1-2), 121-124.  
01-06-2001

Rapalink-1 reveals novel mTOR-dependent genes and an agmatinergic axis-based metabolic feedback regulating mTOR activity and lifespan
Kumar J, Rallis C
In Biorxiv 
Dissecting the cell cycle regulation, DNA damage sensitivity and lifespan effects of caffeine in fission yeast
Alao J-P, Kumar J, Stamataki D, Rallis C
In Biorxiv 
Amino acids whose intracellular levels change most during aging alter chronological lifespan of fission yeast
Rallis C, Mülleder M, Smith G, Au YZ, Ralser M, Bähler J
In Biorxiv 
Caffeine stabilises fission yeast Wee1 in a Rad24-dependent manner but attenuates its expression in response to DNA damage identifying a putative role for TORC1 in mediating its effects on cell cycle progression
Alao JP, Johansson-Sjölander J, Rallis C, Sunnerhagen P
In Biorxiv 
The GATA transcription factor Gaf1 represses tRNA genes, inhibits growth, and extends chronological lifespan downstream of fission yeast TORC1
Rodríguez-López M, Gonzalez S, Hillson O, Tunnacliffe E, Codlin S, Tallada VA, Bähler J, Rallis C
In Biorxiv 
An essential role for dNTP homeostasis following CDK-induced replication stress
Pai C-C, Hsu K-F, Durley SC, Keszthelyi A, Kearsey SE, Rallis C, Folkes LK, Deegan R et al.
In Biorxiv 
Uncovering Natural Longevity Alleles from Intercrossed Pools of Aging Fission Yeast Cells
Ellis DA, Mustonen V, Rodríguez-López M, Rallis C, Malecki M, Jeffares DC, Bähler J
In Biorxiv 
Long non-coding RNA repertoire and regulation by nuclear exosome, cytoplasmic exonuclease and RNAi in fission yeast
Atkinson SR, Marguerat S, Bitton DA, Rodríguez-López M, Rallis C, Lemay J-F, Cotobal C, Malecki M et al.
In Biorxiv 
Functional and Regulatory Profiling of Energy Metabolism in Fission Yeast
Malecki M, Bitton DA, Rodriguez-Lopez M, Rallis C, Cavalia NG, Smith GC, Bahler J
In Preprints.Org 
Transient structural variations have strong effects on quantitative traits and reproductive isolation in fission yeast
Jeffares DC, Jolly C, Hoti M, Speed D, Shaw L, Rallis C, Balloux F, Dessimoz C et al.
In Biorxiv 
Skip and bin: pervasive alternative splicing triggers degradation by nuclear RNA surveillance in fission yeast
Bitton DA, Atkinson SR, Rallis C, Smith GC, Ellis DA, Jeffares DC, Chen YYC, Malecki M et al.
In Biorxiv 
The TOR Signaling Pathway in Spatial and Temporal Control of Cell Size and Growth
Gonzalez S, Rallis C
 

Grants

solid heart iconGrants of specific relevance to Predictive in vitro Models
bullet iconIntegrating cellular space and time: inteplays between subcellular organisation and lifespan-GRANT TRANSFER
Charalampos (Babis) Rallis
£269,451 BBSRC Biotechnology and Biological Sciences Research Council
01-09-2023 - 14-04-2026

bullet iconMechanisms of uncoupling cellular growth from mTOR pathway activity - GRANT TRANSFER
Charalampos (Babis) Rallis
£292,263 MRC Medical Research Council
01-09-2023 - 13-02-2025